FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0601, 852 aa 1>>>pF1KSDA0601 852 - 852 aa - 852 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.8947+/-0.000934; mu= 3.4055+/- 0.057 mean_var=297.2515+/-60.176, 0's: 0 Z-trim(115.1): 15 B-trim: 0 in 0/55 Lambda= 0.074390 statistics sampled from 15688 (15702) to 15688 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.766), E-opt: 0.2 (0.482), width: 16 Scan time: 3.830 The best scores are: opt bits E(32554) CCDS30627.1 KDM1A gene_id:23028|Hs108|chr1 ( 852) 5645 619.7 6.9e-177 CCDS53278.1 KDM1A gene_id:23028|Hs108|chr1 ( 876) 4572 504.5 3.3e-142 CCDS34343.1 KDM1B gene_id:221656|Hs108|chr6 ( 590) 543 72.0 3.6e-12 >>CCDS30627.1 KDM1A gene_id:23028|Hs108|chr1 (852 aa) initn: 5645 init1: 5645 opt: 5645 Z-score: 3289.2 bits: 619.7 E(32554): 6.9e-177 Smith-Waterman score: 5645; 100.0% identity (100.0% similar) in 852 aa overlap (1-852:1-852) 10 20 30 40 50 60 pF1KSD MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA 790 800 810 820 830 840 850 pF1KSD TPGVPAQQSPSM :::::::::::: CCDS30 TPGVPAQQSPSM 850 >>CCDS53278.1 KDM1A gene_id:23028|Hs108|chr1 (876 aa) initn: 4500 init1: 3220 opt: 4572 Z-score: 2666.6 bits: 504.5 E(32554): 3.3e-142 Smith-Waterman score: 5577; 97.3% identity (97.3% similar) in 876 aa overlap (1-852:1-876) 10 20 30 40 50 60 pF1KSD MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY 70 80 90 100 110 120 130 140 150 160 170 pF1KSD REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSG------- ::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGQAGGLQD 130 140 150 160 170 180 180 190 200 210 220 pF1KSD -------------VEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQL ::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 DSSGGYGDGQASGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KSD WLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 WLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGK 250 260 270 280 290 300 290 300 310 320 330 340 pF1KSD VIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 VIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGN 310 320 330 340 350 360 350 360 370 380 390 pF1KSD PMAVVSKQVNMELAKIKQKCPLYEANGQA----VPKEKDEMVEQEFNRLLEATSYLSHQL ::::::::::::::::::::::::::::: ::::::::::::::::::::::::::: CCDS53 PMAVVSKQVNMELAKIKQKCPLYEANGQADTVKVPKEKDEMVEQEFNRLLEATSYLSHQL 370 380 390 400 410 420 400 410 420 430 440 450 pF1KSD DFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 DFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIK 430 440 450 460 470 480 460 470 480 490 500 510 pF1KSD ELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 ELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPP 490 500 510 520 530 540 520 530 540 550 560 570 pF1KSD SDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 SDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPV 550 560 570 580 590 600 580 590 600 610 620 630 pF1KSD ALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 ALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPA 610 620 630 640 650 660 640 650 660 670 680 690 pF1KSD VQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 VQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWN 670 680 690 700 710 720 700 710 720 730 740 750 pF1KSD LYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 LYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPW 730 740 750 760 770 780 760 770 780 790 800 810 pF1KSD ARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 ARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALL 790 800 810 820 830 840 820 830 840 850 pF1KSD SGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM :::::::::::::::::::::::::::::::::::: CCDS53 SGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM 850 860 870 >>CCDS34343.1 KDM1B gene_id:221656|Hs108|chr6 (590 aa) initn: 685 init1: 215 opt: 543 Z-score: 332.0 bits: 72.0 E(32554): 3.6e-12 Smith-Waterman score: 633; 38.3% identity (68.3% similar) in 287 aa overlap (547-826:322-588) 520 530 540 550 560 570 pF1KSD SDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDF-EFTGSHLTVRNGYSCVP .: . ::... : .:.:.: . ::: . CCDS34 DKSFKGVTVGRGAQIVNGCINNPVALMCEQVSARSWDHNEFFAQFAGDHTLLTPGYSVII 300 310 320 330 340 350 580 590 600 610 620 630 pF1KSD VALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPP :::::::.:.. :. . : :: :: ...: .:. :. . :: :.::..: : CCDS34 EKLAEGLDIQLKSPVQCIDY--SGDEVQVTTTDGTG----YSAQKVLVTVPLALL--QKG 360 370 380 390 400 640 650 660 670 680 690 pF1KSD AVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSV---NLFGHVGSTTASRGELF :.:: ::: : : .:.. .: : ..:..: : ::: .: ..:::: ....:: . CCDS34 AIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGADFFGHVPPSASKRGLFA 410 420 430 440 450 460 700 710 720 730 740 pF1KSD LFWNL---YKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVS .:... : .:....::::.. .....: .. .:.: :. .: . ::.: . :. CCDS34 VFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVT 470 480 490 500 510 520 750 760 770 780 790 800 pF1KSD RWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPA :: .::: . .::.: .:.::. ::..:. .: :. .::::: : :..: CCDS34 RWSTDPWIQMAYSFVKTGGSGEAYDIIAE------DIQGT------VFFAGEATNRHFPQ 530 540 550 560 570 810 820 830 840 850 pF1KSD TVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM :: :: :::.:::..:: CCDS34 TVTGAYLSGVREASKIAAF 580 590 852 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 02:14:39 2016 done: Thu Nov 3 02:14:40 2016 Total Scan time: 3.830 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]