FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0645, 1572 aa 1>>>pF1KSDA0645 1572 - 1572 aa - 1572 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0790+/-0.00043; mu= 14.9619+/- 0.027 mean_var=94.9001+/-18.701, 0's: 0 Z-trim(112.8): 51 B-trim: 1150 in 1/49 Lambda= 0.131656 statistics sampled from 21867 (21905) to 21867 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.601), E-opt: 0.2 (0.257), width: 16 Scan time: 14.490 The best scores are: opt bits E(85289) XP_011528861 (OMIM: 604364,614191) PREDICTED: DEP (1572) 10626 2029.6 0 XP_016884600 (OMIM: 604364,614191) PREDICTED: DEP (1572) 10626 2029.6 0 NP_055477 (OMIM: 604364,614191) DEP domain-contain (1572) 10626 2029.6 0 XP_011528859 (OMIM: 604364,614191) PREDICTED: DEP (1594) 7302 1398.2 0 NP_001129501 (OMIM: 604364,614191) DEP domain-cont (1594) 7302 1398.2 0 XP_016884598 (OMIM: 604364,614191) PREDICTED: DEP (1594) 7302 1398.2 0 NP_001229826 (OMIM: 604364,614191) DEP domain-cont (1503) 5790 1111.0 0 XP_011528865 (OMIM: 604364,614191) PREDICTED: DEP (1503) 5790 1111.0 0 XP_016884599 (OMIM: 604364,614191) PREDICTED: DEP (1581) 5790 1111.0 0 XP_011528860 (OMIM: 604364,614191) PREDICTED: DEP (1581) 5790 1111.0 0 XP_016884602 (OMIM: 604364,614191) PREDICTED: DEP ( 727) 4847 931.9 0 XP_011528870 (OMIM: 604364,614191) PREDICTED: DEP (1176) 4844 931.3 0 XP_011528867 (OMIM: 604364,614191) PREDICTED: DEP (1307) 4844 931.3 0 XP_011528864 (OMIM: 604364,614191) PREDICTED: DEP (1515) 4844 931.4 0 NP_001229825 (OMIM: 604364,614191) DEP domain-cont (1603) 4844 931.4 0 XP_005261919 (OMIM: 604364,614191) PREDICTED: DEP (1603) 4844 931.4 0 XP_016884603 (OMIM: 604364,614191) PREDICTED: DEP ( 716) 4690 902.0 0 XP_016884604 (OMIM: 604364,614191) PREDICTED: DEP ( 649) 4186 806.3 0 XP_011528863 (OMIM: 604364,614191) PREDICTED: DEP (1516) 4184 806.0 0 XP_011528862 (OMIM: 604364,614191) PREDICTED: DEP (1525) 4184 806.0 0 XP_016884601 (OMIM: 604364,614191) PREDICTED: DEP (1525) 4184 806.0 0 NP_001007189 (OMIM: 604364,614191) DEP domain-cont ( 559) 3697 713.4 1.3e-204 XP_011528871 (OMIM: 604364,614191) PREDICTED: DEP ( 901) 3333 644.3 1.3e-183 >>XP_011528861 (OMIM: 604364,614191) PREDICTED: DEP doma (1572 aa) initn: 10626 init1: 10626 opt: 10626 Z-score: 10899.5 bits: 2029.6 E(85289): 0 Smith-Waterman score: 10626; 100.0% identity (100.0% similar) in 1572 aa overlap (1-1572:1-1572) 10 20 30 40 50 60 pF1KSD MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD PDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDED 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD GVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD DQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD HERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIY 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLEST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLEST 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD APPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD SVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD TSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIM 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD QKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAGVDDFASFQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAGVDDFASFQR 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KSD KWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQ 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KSD RTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATS 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KSD CGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHL 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KSD FQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNST 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KSD SSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFW 1510 1520 1530 1540 1550 1560 1570 pF1KSD TSCLEKMHASAP :::::::::::: XP_011 TSCLEKMHASAP 1570 >>XP_016884600 (OMIM: 604364,614191) PREDICTED: DEP doma (1572 aa) initn: 10626 init1: 10626 opt: 10626 Z-score: 10899.5 bits: 2029.6 E(85289): 0 Smith-Waterman score: 10626; 100.0% identity (100.0% similar) in 1572 aa overlap (1-1572:1-1572) 10 20 30 40 50 60 pF1KSD MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD PDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDED 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD GVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD DQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD HERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIY 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLEST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLEST 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD APPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD SVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD TSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIM 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD QKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAGVDDFASFQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAGVDDFASFQR 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KSD KWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQ 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KSD RTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATS 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KSD CGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHL 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KSD FQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNST 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KSD SSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFW 1510 1520 1530 1540 1550 1560 1570 pF1KSD TSCLEKMHASAP :::::::::::: XP_016 TSCLEKMHASAP 1570 >>NP_055477 (OMIM: 604364,614191) DEP domain-containing (1572 aa) initn: 10626 init1: 10626 opt: 10626 Z-score: 10899.5 bits: 2029.6 E(85289): 0 Smith-Waterman score: 10626; 100.0% identity (100.0% similar) in 1572 aa overlap (1-1572:1-1572) 10 20 30 40 50 60 pF1KSD MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD PDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDED 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD GVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD DQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD HERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 HERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIY 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLEST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLEST 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD APPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 APPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD SVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSSSQQLVASSL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD TSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQTQAMAIDIM 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD QKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAGVDDFASFQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAGVDDFASFQR 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KSD KWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAALLAATVPEQ 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KSD RTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMVQGWHRKATS 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KSD CGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 CGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEPETYWDRMHL 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KSD FQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 FQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSGQQRRRRNST 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KSD SSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCINRDNRLVTFW 1510 1520 1530 1540 1550 1560 1570 pF1KSD TSCLEKMHASAP :::::::::::: NP_055 TSCLEKMHASAP 1570 >>XP_011528859 (OMIM: 604364,614191) PREDICTED: DEP doma (1594 aa) initn: 7295 init1: 7295 opt: 7302 Z-score: 7487.3 bits: 1398.2 E(85289): 0 Smith-Waterman score: 10572; 98.6% identity (98.6% similar) in 1594 aa overlap (1-1572:1-1594) 10 20 30 40 50 60 pF1KSD MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD PDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDED 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD GVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD DQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD HERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIY 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLEST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLEST 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KSD APPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRK- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKD 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 pF1KSD ---------------------VSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIG ::::::::::::::::::::::::::::::::::::::: XP_011 GAFFMEFVRSPRTASSAFYPQVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIG 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KSD EQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAE 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KSD VVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRV 1210 1220 1230 1240 1250 1260 1240 1250 1260 1270 1280 1290 pF1KSD AMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSS 1270 1280 1290 1300 1310 1320 1300 1310 1320 1330 1340 1350 pF1KSD FSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLH 1330 1340 1350 1360 1370 1380 1360 1370 1380 1390 1400 1410 pF1KSD WMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLL 1390 1400 1410 1420 1430 1440 1420 1430 1440 1450 1460 1470 pF1KSD KEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTV 1450 1460 1470 1480 1490 1500 1480 1490 1500 1510 1520 1530 pF1KSD FLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFA 1510 1520 1530 1540 1550 1560 1540 1550 1560 1570 pF1KSD DRLLKDFTDFCINRDNRLVTFWTSCLEKMHASAP :::::::::::::::::::::::::::::::::: XP_011 DRLLKDFTDFCINRDNRLVTFWTSCLEKMHASAP 1570 1580 1590 >>NP_001129501 (OMIM: 604364,614191) DEP domain-containi (1594 aa) initn: 7295 init1: 7295 opt: 7302 Z-score: 7487.3 bits: 1398.2 E(85289): 0 Smith-Waterman score: 10572; 98.6% identity (98.6% similar) in 1594 aa overlap (1-1572:1-1594) 10 20 30 40 50 60 pF1KSD MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD PDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDED 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD GVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD DQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD HERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIY 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLEST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLEST 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KSD APPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRK- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKD 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 pF1KSD ---------------------VSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIG ::::::::::::::::::::::::::::::::::::::: NP_001 GAFFMEFVRSPRTASSAFYPQVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIG 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KSD EQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAE 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KSD VVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRV 1210 1220 1230 1240 1250 1260 1240 1250 1260 1270 1280 1290 pF1KSD AMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSS 1270 1280 1290 1300 1310 1320 1300 1310 1320 1330 1340 1350 pF1KSD FSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLH 1330 1340 1350 1360 1370 1380 1360 1370 1380 1390 1400 1410 pF1KSD WMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLL 1390 1400 1410 1420 1430 1440 1420 1430 1440 1450 1460 1470 pF1KSD KEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTV 1450 1460 1470 1480 1490 1500 1480 1490 1500 1510 1520 1530 pF1KSD FLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFA 1510 1520 1530 1540 1550 1560 1540 1550 1560 1570 pF1KSD DRLLKDFTDFCINRDNRLVTFWTSCLEKMHASAP :::::::::::::::::::::::::::::::::: NP_001 DRLLKDFTDFCINRDNRLVTFWTSCLEKMHASAP 1570 1580 1590 >>XP_016884598 (OMIM: 604364,614191) PREDICTED: DEP doma (1594 aa) initn: 7295 init1: 7295 opt: 7302 Z-score: 7487.3 bits: 1398.2 E(85289): 0 Smith-Waterman score: 10572; 98.6% identity (98.6% similar) in 1594 aa overlap (1-1572:1-1594) 10 20 30 40 50 60 pF1KSD MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD PDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDED 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD GVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD DQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSEFVSCWVEFS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD HERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRITEGEAHCDIY 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD GDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLEST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGPISTHSLEST 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KSD APPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRK- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTPTYMDSPRKD 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 pF1KSD ---------------------VSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIG ::::::::::::::::::::::::::::::::::::::: XP_016 GAFFMEFVRSPRTASSAFYPQVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIG 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KSD EQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAE 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KSD VVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRV 1210 1220 1230 1240 1250 1260 1240 1250 1260 1270 1280 1290 pF1KSD AMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSS 1270 1280 1290 1300 1310 1320 1300 1310 1320 1330 1340 1350 pF1KSD FSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLH 1330 1340 1350 1360 1370 1380 1360 1370 1380 1390 1400 1410 pF1KSD WMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLL 1390 1400 1410 1420 1430 1440 1420 1430 1440 1450 1460 1470 pF1KSD KEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTV 1450 1460 1470 1480 1490 1500 1480 1490 1500 1510 1520 1530 pF1KSD FLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFA 1510 1520 1530 1540 1550 1560 1540 1550 1560 1570 pF1KSD DRLLKDFTDFCINRDNRLVTFWTSCLEKMHASAP :::::::::::::::::::::::::::::::::: XP_016 DRLLKDFTDFCINRDNRLVTFWTSCLEKMHASAP 1570 1580 1590 >>NP_001229826 (OMIM: 604364,614191) DEP domain-containi (1503 aa) initn: 9960 init1: 5790 opt: 5790 Z-score: 5935.6 bits: 1111.0 E(85289): 0 Smith-Waterman score: 9913; 94.4% identity (94.5% similar) in 1581 aa overlap (1-1572:1-1503) 10 20 30 40 50 60 pF1KSD MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE :::::::::::::::::::::::: NP_001 FAPSRMPMKLTSNRRRWMHTFPVG------------------------------------ 610 620 670 680 690 700 710 720 pF1KSD LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS :::::::::::::::::: NP_001 ------------------------------------------MNPRTQNKDSLEDSVSTS 630 640 730 740 750 760 770 pF1KSD PDPM---------PGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPE :::. ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPE 650 660 670 680 690 700 780 790 800 810 820 830 pF1KSD ADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGL 710 720 730 740 750 760 840 850 860 870 880 890 pF1KSD VSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSE 770 780 790 800 810 820 900 910 920 930 940 950 pF1KSD FVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRIT 830 840 850 860 870 880 960 970 980 990 1000 1010 pF1KSD EGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGP 890 900 910 920 930 940 1020 1030 1040 1050 1060 1070 pF1KSD ISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTP 950 960 970 980 990 1000 1080 1090 1100 1110 1120 1130 pF1KSD TYMDSPRKVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TYMDSPRKVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSS 1010 1020 1030 1040 1050 1060 1140 1150 1160 1170 1180 1190 pF1KSD SQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQ 1070 1080 1090 1100 1110 1120 1200 1210 1220 1230 1240 1250 pF1KSD TQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAG 1130 1140 1150 1160 1170 1180 1260 1270 1280 1290 1300 1310 pF1KSD VDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAA 1190 1200 1210 1220 1230 1240 1320 1330 1340 1350 1360 1370 pF1KSD LLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMV 1250 1260 1270 1280 1290 1300 1380 1390 1400 1410 1420 1430 pF1KSD QGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEP 1310 1320 1330 1340 1350 1360 1440 1450 1460 1470 1480 1490 pF1KSD ETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSG 1370 1380 1390 1400 1410 1420 1500 1510 1520 1530 1540 1550 pF1KSD QQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCIN 1430 1440 1450 1460 1470 1480 1560 1570 pF1KSD RDNRLVTFWTSCLEKMHASAP ::::::::::::::::::::: NP_001 RDNRLVTFWTSCLEKMHASAP 1490 1500 >>XP_011528865 (OMIM: 604364,614191) PREDICTED: DEP doma (1503 aa) initn: 9960 init1: 5790 opt: 5790 Z-score: 5935.6 bits: 1111.0 E(85289): 0 Smith-Waterman score: 9913; 94.4% identity (94.5% similar) in 1581 aa overlap (1-1572:1-1503) 10 20 30 40 50 60 pF1KSD MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE :::::::::::::::::::::::: XP_011 FAPSRMPMKLTSNRRRWMHTFPVG------------------------------------ 610 620 670 680 690 700 710 720 pF1KSD LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS :::::::::::::::::: XP_011 ------------------------------------------MNPRTQNKDSLEDSVSTS 630 640 730 740 750 760 770 pF1KSD PDPM---------PGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPE :::. ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPE 650 660 670 680 690 700 780 790 800 810 820 830 pF1KSD ADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGL 710 720 730 740 750 760 840 850 860 870 880 890 pF1KSD VSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSE 770 780 790 800 810 820 900 910 920 930 940 950 pF1KSD FVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRIT 830 840 850 860 870 880 960 970 980 990 1000 1010 pF1KSD EGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGP 890 900 910 920 930 940 1020 1030 1040 1050 1060 1070 pF1KSD ISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTP 950 960 970 980 990 1000 1080 1090 1100 1110 1120 1130 pF1KSD TYMDSPRKVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TYMDSPRKVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSS 1010 1020 1030 1040 1050 1060 1140 1150 1160 1170 1180 1190 pF1KSD SQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQ 1070 1080 1090 1100 1110 1120 1200 1210 1220 1230 1240 1250 pF1KSD TQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAG 1130 1140 1150 1160 1170 1180 1260 1270 1280 1290 1300 1310 pF1KSD VDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAA 1190 1200 1210 1220 1230 1240 1320 1330 1340 1350 1360 1370 pF1KSD LLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMV 1250 1260 1270 1280 1290 1300 1380 1390 1400 1410 1420 1430 pF1KSD QGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEP 1310 1320 1330 1340 1350 1360 1440 1450 1460 1470 1480 1490 pF1KSD ETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSG 1370 1380 1390 1400 1410 1420 1500 1510 1520 1530 1540 1550 pF1KSD QQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCIN 1430 1440 1450 1460 1470 1480 1560 1570 pF1KSD RDNRLVTFWTSCLEKMHASAP ::::::::::::::::::::: XP_011 RDNRLVTFWTSCLEKMHASAP 1490 1500 >>XP_016884599 (OMIM: 604364,614191) PREDICTED: DEP doma (1581 aa) initn: 5790 init1: 5790 opt: 5790 Z-score: 5935.3 bits: 1111.0 E(85289): 0 Smith-Waterman score: 10593; 99.4% identity (99.4% similar) in 1581 aa overlap (1-1572:1-1581) 10 20 30 40 50 60 pF1KSD MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS 670 680 690 700 710 720 730 740 750 760 770 pF1KSD PDPM---------PGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPE :::. ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPE 730 740 750 760 770 780 780 790 800 810 820 830 pF1KSD ADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGL 790 800 810 820 830 840 840 850 860 870 880 890 pF1KSD VSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSE 850 860 870 880 890 900 900 910 920 930 940 950 pF1KSD FVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRIT 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KSD EGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGP 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KSD ISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTP 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KSD TYMDSPRKVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TYMDSPRKVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSS 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KSD SQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQ 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KSD TQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAG 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KSD VDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAA 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KSD LLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMV 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 1430 pF1KSD QGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEP 1390 1400 1410 1420 1430 1440 1440 1450 1460 1470 1480 1490 pF1KSD ETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSG 1450 1460 1470 1480 1490 1500 1500 1510 1520 1530 1540 1550 pF1KSD QQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCIN 1510 1520 1530 1540 1550 1560 1560 1570 pF1KSD RDNRLVTFWTSCLEKMHASAP ::::::::::::::::::::: XP_016 RDNRLVTFWTSCLEKMHASAP 1570 1580 >>XP_011528860 (OMIM: 604364,614191) PREDICTED: DEP doma (1581 aa) initn: 5790 init1: 5790 opt: 5790 Z-score: 5935.3 bits: 1111.0 E(85289): 0 Smith-Waterman score: 10593; 99.4% identity (99.4% similar) in 1581 aa overlap (1-1572:1-1581) 10 20 30 40 50 60 pF1KSD MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS 670 680 690 700 710 720 730 740 750 760 770 pF1KSD PDPM---------PGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPE :::. ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPE 730 740 750 760 770 780 780 790 800 810 820 830 pF1KSD ADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGL 790 800 810 820 830 840 840 850 860 870 880 890 pF1KSD VSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSE 850 860 870 880 890 900 900 910 920 930 940 950 pF1KSD FVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRIT 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KSD EGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGP 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KSD ISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTP 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KSD TYMDSPRKVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TYMDSPRKVSVDQTATPMLDGTSLGICTGQSMDRGNSQTFGNSQNIGEQGYSSTNSSDSS 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KSD SQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISAEVVHWLVNHVEGIQ 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KSD TQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKIVTDKEPDRVAMQQPATTWHTAG 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KSD VDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRPASYASRHSSFSRSFGGRSQAAA 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KSD LLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSLNAAFEIKLHWMAVTAAVLFEMV 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 1430 pF1KSD QGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLFIPLNISCLLKEGSEHLFDSFEP 1390 1400 1410 1420 1430 1440 1440 1450 1460 1470 1480 1490 pF1KSD ETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKPQYIHVTGTVFLQLPYSKRKFSG 1450 1460 1470 1480 1490 1500 1500 1510 1520 1530 1540 1550 pF1KSD QQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRSSATGDEKFADRLLKDFTDFCIN 1510 1520 1530 1540 1550 1560 1560 1570 pF1KSD RDNRLVTFWTSCLEKMHASAP ::::::::::::::::::::: XP_011 RDNRLVTFWTSCLEKMHASAP 1570 1580 1572 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 02:28:50 2016 done: Thu Nov 3 02:28:52 2016 Total Scan time: 14.490 Total Display time: 0.870 Function used was FASTA [36.3.4 Apr, 2011]