Result of FASTA (omim) for
pF1KSDA0658
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0658, 593 aa
1>>>pF1KSDA0658 593 - 593 aa - 593 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.9988+/-0.000325; mu= 11.5887+/- 0.020
mean_var=113.5387+/-22.902, 0's: 0 Z-trim(118.5): 4 B-trim: 237 in 1/54
Lambda= 0.120366
statistics sampled from 31595 (31599) to 31595 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.72), E-opt: 0.2 (0.37), width: 16
Scan time: 8.750
The best scores are: opt bits E(85289)
NP_066940 (OMIM: 603732) cryptochrome-2 isoform 1 ( 614) 4096 722.2 1.2e-207
NP_001120929 (OMIM: 603732) cryptochrome-2 isoform ( 532) 3607 637.3 4e-182
NP_004066 (OMIM: 601933) cryptochrome-1 [Homo sapi ( 586) 2978 528.0 3.3e-149
XP_016874321 (OMIM: 601933) PREDICTED: cryptochrom ( 558) 2697 479.2 1.5e-134
>>NP_066940 (OMIM: 603732) cryptochrome-2 isoform 1 [Hom (614 aa)
initn: 4096 init1: 4096 opt: 4096 Z-score: 3848.7 bits: 722.2 E(85289): 1.2e-207
Smith-Waterman score: 4096; 100.0% identity (100.0% similar) in 593 aa overlap (1-593:22-614)
10 20 30
pF1KSD MAATVATAAAVAPAPAPGTDSASSVHWFRKGLRLHDNPA
:::::::::::::::::::::::::::::::::::::::
NP_066 MGGVHVAYRGGAGVAGAVWTVMAATVATAAAVAPAPAPGTDSASSVHWFRKGLRLHDNPA
10 20 30 40 50 60
40 50 60 70 80 90
pF1KSD LLAAVRGARCVRCVYILDPWFAASSSVGINRWRFLLQSLEDLDTSLRKLNSRLFVVRGQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 LLAAVRGARCVRCVYILDPWFAASSSVGINRWRFLLQSLEDLDTSLRKLNSRLFVVRGQP
70 80 90 100 110 120
100 110 120 130 140 150
pF1KSD ADVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 ADVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIE
130 140 150 160 170 180
160 170 180 190 200 210
pF1KSD LNGQKPPLTYKRFQAIISRMELPKKPVGLVTSQQMESCRAEIQENHDETYGVPSLEELGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 LNGQKPPLTYKRFQAIISRMELPKKPVGLVTSQQMESCRAEIQENHDETYGVPSLEELGF
190 200 210 220 230 240
220 230 240 250 260 270
pF1KSD PTEGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLASPTGLSPYLRFGCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 PTEGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLASPTGLSPYLRFGCL
250 260 270 280 290 300
280 290 300 310 320 330
pF1KSD SCRLFYYRLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SCRLFYYRLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPW
310 320 330 340 350 360
340 350 360 370 380 390
pF1KSD DRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 DRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVRV
370 380 390 400 410 420
400 410 420 430 440 450
pF1KSD FDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKAFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 FDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKAFP
430 440 450 460 470 480
460 470 480 490 500 510
pF1KSD SRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCLL
490 500 510 520 530 540
520 530 540 550 560 570
pF1KSD ASVPSCVEDLSHPVAEPSSSQAGSMSSAGPRPLPSGPASPKRKLEAAEEPPGEELSKRAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 ASVPSCVEDLSHPVAEPSSSQAGSMSSAGPRPLPSGPASPKRKLEAAEEPPGEELSKRAR
550 560 570 580 590 600
580 590
pF1KSD VAELPTPELPSKDA
::::::::::::::
NP_066 VAELPTPELPSKDA
610
>>NP_001120929 (OMIM: 603732) cryptochrome-2 isoform 2 [ (532 aa)
initn: 3604 init1: 3604 opt: 3607 Z-score: 3390.8 bits: 637.3 E(85289): 4e-182
Smith-Waterman score: 3607; 99.8% identity (99.8% similar) in 523 aa overlap (71-593:11-532)
50 60 70 80 90 100
pF1KSD LAAVRGARCVRCVYILDPWFAASSSVGINRWRFLLQSLEDLDTSLRKLNSRLFVVRGQPA
: ::::::::::::::::::::::::::::
NP_001 MPAPPGRTHTW-FLLQSLEDLDTSLRKLNSRLFVVRGQPA
10 20 30
110 120 130 140 150 160
pF1KSD DVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIEL
40 50 60 70 80 90
170 180 190 200 210 220
pF1KSD NGQKPPLTYKRFQAIISRMELPKKPVGLVTSQQMESCRAEIQENHDETYGVPSLEELGFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGQKPPLTYKRFQAIISRMELPKKPVGLVTSQQMESCRAEIQENHDETYGVPSLEELGFP
100 110 120 130 140 150
230 240 250 260 270 280
pF1KSD TEGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLASPTGLSPYLRFGCLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLASPTGLSPYLRFGCLS
160 170 180 190 200 210
290 300 310 320 330 340
pF1KSD CRLFYYRLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CRLFYYRLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWD
220 230 240 250 260 270
350 360 370 380 390 400
pF1KSD RNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVRVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVRVF
280 290 300 310 320 330
410 420 430 440 450 460
pF1KSD DELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKAFPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKAFPS
340 350 360 370 380 390
470 480 490 500 510 520
pF1KSD RYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCLLA
400 410 420 430 440 450
530 540 550 560 570 580
pF1KSD SVPSCVEDLSHPVAEPSSSQAGSMSSAGPRPLPSGPASPKRKLEAAEEPPGEELSKRARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVPSCVEDLSHPVAEPSSSQAGSMSSAGPRPLPSGPASPKRKLEAAEEPPGEELSKRARV
460 470 480 490 500 510
590
pF1KSD AELPTPELPSKDA
:::::::::::::
NP_001 AELPTPELPSKDA
520 530
>>NP_004066 (OMIM: 601933) cryptochrome-1 [Homo sapiens] (586 aa)
initn: 2976 init1: 2976 opt: 2978 Z-score: 2799.8 bits: 528.0 E(85289): 3.3e-149
Smith-Waterman score: 2978; 74.8% identity (89.3% similar) in 563 aa overlap (23-579:4-566)
10 20 30 40 50 60
pF1KSD MAATVATAAAVAPAPAPGTDSASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWF
..:::::::::::::::: ..:: .::::::::::
NP_004 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWF
10 20 30 40
70 80 90 100 110 120
pF1KSD AASSSVGINRWRFLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFKEWGVTRLTFEYD
:.::.::::::::::: :::::..::::::::::.:::::::::::::::..:.:..:::
NP_004 AGSSNVGINRWRFLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFKEWNITKLSIEYD
50 60 70 80 90 100
130 140 150 160 170 180
pF1KSD SEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIELNGQKPPLTYKRFQAIISRME
:::::::::::: :.: ::::::... ::::::::.:::::: .:::::::::..::.::
NP_004 SEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDKIIELNGGQPPLTYKRFQTLISKME
110 120 130 140 150 160
190 200 210 220 230 240
pF1KSD LPKKPVGLVTSQQMESCRAEIQENHDETYGVPSLEELGFPTEGLGPAVWQGGETEALARL
. :: .::. .:.: . ....::: ::::::::::: :.::. ::: :::::::.::
NP_004 PLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEELGFDTDGLSSAVWPGGETEALTRL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KSD DKHLERKAWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKKVKRNST
..::::::::::.::::::::::::::::::::::::::::::::..: :::::::.::.
NP_004 ERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNSS
230 240 250 260 270 280
310 320 330 340 350 360
pF1KSD PPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWID
:::::.::::::::::::::::::::.:::::::.:::::.:::::::::::.:::::::
NP_004 PPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWID
290 300 310 320 330 340
370 380 390 400 410 420
pF1KSD AIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVRVFDELLLDADFSVNAGSWMWLS
::::::::::::::::::::::::::::::.::: :..::.:::::::.:.:::::::::
NP_004 AIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDADWSINAGSWMWLS
350 360 370 380 390 400
430 440 450 460 470 480
pF1KSD CSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKAFPSRYIYEPWNAPESIQKAAKCI
::.::::::::::::::::::::.::::::::: :..::..:::.::::::.:::.:::.
NP_004 CSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNAPEGIQKVAKCL
410 420 430 440 450 460
490 500 510 520 530
pF1KSD IGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCLLASVPSCVED---LSHPVAE--
:::.::.:.:::::.::::::::::::::::::::: ::::::: . . ::
NP_004 IGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGLGLLASVPSNPNGNGGFMGYSAENI
470 480 490 500 510 520
540 550 560 570 580 590
pF1KSD PSSSQAGSMSS-AGPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDA
:. :..:: :. .: : .. . :. .. : :: :
NP_004 PGCSSSGSCSQGSGILHYAHGDSQQTHLLKQGRSSMGTGLSGGKRPSQEEDTQSIGPKVQ
530 540 550 560 570 580
NP_004 RQSTN
>>XP_016874321 (OMIM: 601933) PREDICTED: cryptochrome-1 (558 aa)
initn: 2695 init1: 2695 opt: 2697 Z-score: 2536.4 bits: 479.2 E(85289): 1.5e-134
Smith-Waterman score: 2697; 74.5% identity (89.0% similar) in 517 aa overlap (69-579:22-538)
40 50 60 70 80 90
pF1KSD ALLAAVRGARCVRCVYILDPWFAASSSVGINRWRFLLQSLEDLDTSLRKLNSRLFVVRGQ
: ::::: :::::..::::::::::.:::
XP_016 MMIIFHKMMASYSNTTYWIISNSVRFLLQCLEDLDANLRKLNSRLFVIRGQ
10 20 30 40 50
100 110 120 130 140 150
pF1KSD PADVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRII
::::::::::::..:.:..::::::::::::::: :.: ::::::... ::::::::.::
XP_016 PADVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDKII
60 70 80 90 100 110
160 170 180 190 200 210
pF1KSD ELNGQKPPLTYKRFQAIISRMELPKKPVGLVTSQQMESCRAEIQENHDETYGVPSLEELG
:::: .:::::::::..::.:: . :: .::. .:.: . ....::: ::::::::::
XP_016 ELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEELG
120 130 140 150 160 170
220 230 240 250 260 270
pF1KSD FPTEGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLASPTGLSPYLRFGC
: :.::. ::: :::::::.::..::::::::::.:::::::::::::::::::::::::
XP_016 FDTDGLSSAVWPGGETEALTRLERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGC
180 190 200 210 220 230
280 290 300 310 320 330
pF1KSD LSCRLFYYRLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIP
:::::::..: :::::::.::.:::::.::::::::::::::::::::.:::::::.:::
XP_016 LSCRLFYFKLTDLYKKVKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIP
240 250 260 270 280 290
340 350 360 370 380 390
pF1KSD WDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR
::.:::::::::::.:::::::::::::::::::::::::::::::::::::.::: :..
XP_016 WDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK
300 310 320 330 340 350
400 410 420 430 440 450
pF1KSD VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKAF
::.:::::::.:.:::::::::::.::::::::::::::::::::.::::::::: :..:
XP_016 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLRGF
360 370 380 390 400 410
460 470 480 490 500 510
pF1KSD PSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCL
:..:::.::::::.:::.:::.:::.::.:.:::::.::::::::::::::::::::: :
XP_016 PAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGLGL
420 430 440 450 460 470
520 530 540 550 560 570
pF1KSD LASVPSCVED---LSHPVAE--PSSSQAGSMSS-AGPRPLPSGPASPKRKLEAAEEPPGE
:::::: . . :: :. :..:: :. .: : .. . :. .. :
XP_016 LASVPSNPNGNGGFMGYSAENIPGCSSSGSCSQGSGILHYAHGDSQQTHLLKQGRSSMGT
480 490 500 510 520 530
580 590
pF1KSD ELSKRARVAELPTPELPSKDA
:: :
XP_016 GLSGGKRPSQEEDTQSIGPKVQRQSTN
540 550
593 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 02:33:07 2016 done: Thu Nov 3 02:33:08 2016
Total Scan time: 8.750 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]