Result of FASTA (omim) for
pF1KSDA0733
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0733, 693 aa
1>>>pF1KSDA0733 693 - 693 aa - 693 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.6287+/-0.000443; mu= -10.2481+/- 0.027
mean_var=333.4519+/-67.915, 0's: 0 Z-trim(119.7): 33 B-trim: 0 in 0/58
Lambda= 0.070236
statistics sampled from 34101 (34134) to 34101 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.735), E-opt: 0.2 (0.4), width: 16
Scan time: 10.850
The best scores are: opt bits E(85289)
XP_016866081 (OMIM: 605101,614980) PREDICTED: TGF- ( 693) 4679 488.5 3.7e-137
XP_011533935 (OMIM: 605101,614980) PREDICTED: TGF- ( 693) 4679 488.5 3.7e-137
XP_016866080 (OMIM: 605101,614980) PREDICTED: TGF- ( 693) 4679 488.5 3.7e-137
NP_001278963 (OMIM: 605101,614980) TGF-beta-activa ( 693) 4679 488.5 3.7e-137
NP_055908 (OMIM: 605101,614980) TGF-beta-activated ( 693) 4679 488.5 3.7e-137
NP_001278964 (OMIM: 605101,614980) TGF-beta-activa ( 661) 4455 465.8 2.4e-130
XP_005274541 (OMIM: 300480) PREDICTED: TGF-beta-ac ( 678) 819 97.3 2e-19
XP_016884889 (OMIM: 300480) PREDICTED: TGF-beta-ac ( 721) 616 76.8 3.3e-13
XP_016884888 (OMIM: 300480) PREDICTED: TGF-beta-ac ( 721) 616 76.8 3.3e-13
NP_690000 (OMIM: 300480) TGF-beta-activated kinase ( 712) 612 76.4 4.3e-13
XP_016884890 (OMIM: 300480) PREDICTED: TGF-beta-ac ( 634) 609 76.0 4.8e-13
XP_005274540 (OMIM: 300480) PREDICTED: TGF-beta-ac ( 684) 522 67.2 2.3e-10
XP_011543790 (OMIM: 300480) PREDICTED: TGF-beta-ac ( 632) 517 66.7 3.1e-10
XP_016884891 (OMIM: 300480) PREDICTED: TGF-beta-ac ( 626) 511 66.1 4.6e-10
>>XP_016866081 (OMIM: 605101,614980) PREDICTED: TGF-beta (693 aa)
initn: 4679 init1: 4679 opt: 4679 Z-score: 2583.4 bits: 488.5 E(85289): 3.7e-137
Smith-Waterman score: 4679; 100.0% identity (100.0% similar) in 693 aa overlap (1-693:1-693)
10 20 30 40 50 60
pF1KSD MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD NFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD LFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD LAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD PMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD SGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD NMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD VSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD KARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD QLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDT
610 620 630 640 650 660
670 680 690
pF1KSD EDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
:::::::::::::::::::::::::::::::::
XP_016 EDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
670 680 690
>>XP_011533935 (OMIM: 605101,614980) PREDICTED: TGF-beta (693 aa)
initn: 4679 init1: 4679 opt: 4679 Z-score: 2583.4 bits: 488.5 E(85289): 3.7e-137
Smith-Waterman score: 4679; 100.0% identity (100.0% similar) in 693 aa overlap (1-693:1-693)
10 20 30 40 50 60
pF1KSD MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD NFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD LFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD LAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD PMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD SGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD NMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD VSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD KARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD QLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDT
610 620 630 640 650 660
670 680 690
pF1KSD EDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
:::::::::::::::::::::::::::::::::
XP_011 EDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
670 680 690
>>XP_016866080 (OMIM: 605101,614980) PREDICTED: TGF-beta (693 aa)
initn: 4679 init1: 4679 opt: 4679 Z-score: 2583.4 bits: 488.5 E(85289): 3.7e-137
Smith-Waterman score: 4679; 100.0% identity (100.0% similar) in 693 aa overlap (1-693:1-693)
10 20 30 40 50 60
pF1KSD MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD NFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD LFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD LAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD PMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD SGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD NMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD VSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD KARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD QLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDT
610 620 630 640 650 660
670 680 690
pF1KSD EDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
:::::::::::::::::::::::::::::::::
XP_016 EDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
670 680 690
>>NP_001278963 (OMIM: 605101,614980) TGF-beta-activated (693 aa)
initn: 4679 init1: 4679 opt: 4679 Z-score: 2583.4 bits: 488.5 E(85289): 3.7e-137
Smith-Waterman score: 4679; 100.0% identity (100.0% similar) in 693 aa overlap (1-693:1-693)
10 20 30 40 50 60
pF1KSD MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD NFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD LFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD LAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD PMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD SGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD NMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD VSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD KARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD QLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDT
610 620 630 640 650 660
670 680 690
pF1KSD EDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
:::::::::::::::::::::::::::::::::
NP_001 EDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
670 680 690
>>NP_055908 (OMIM: 605101,614980) TGF-beta-activated kin (693 aa)
initn: 4679 init1: 4679 opt: 4679 Z-score: 2583.4 bits: 488.5 E(85289): 3.7e-137
Smith-Waterman score: 4679; 100.0% identity (100.0% similar) in 693 aa overlap (1-693:1-693)
10 20 30 40 50 60
pF1KSD MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD NFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD LFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD LAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD PMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD SGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD NRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NRNQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD NMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NMSGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD VSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD KARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD QLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDT
610 620 630 640 650 660
670 680 690
pF1KSD EDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
:::::::::::::::::::::::::::::::::
NP_055 EDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
670 680 690
>>NP_001278964 (OMIM: 605101,614980) TGF-beta-activated (661 aa)
initn: 4455 init1: 4455 opt: 4455 Z-score: 2461.1 bits: 465.8 E(85289): 2.4e-130
Smith-Waterman score: 4455; 99.8% identity (100.0% similar) in 661 aa overlap (33-693:1-661)
10 20 30 40 50 60
pF1KSD QGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNF
.:::::::::::::::::::::::::::::
NP_001 MQNNNNLDACCAVLSQESTRYLYGEGDLNF
10 20 30
70 80 90 100 110 120
pF1KSD SDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSELF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSELF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KSD QQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVTLA
100 110 120 130 140 150
190 200 210 220 230 240
pF1KSD PNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFNPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFNPM
160 170 180 190 200 210
250 260 270 280 290 300
pF1KSD NPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHSSG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KSD SSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTLNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTLNR
280 290 300 310 320 330
370 380 390 400 410 420
pF1KSD NQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQPTVYIAASPPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNM
340 350 360 370 380 390
430 440 450 460 470 480
pF1KSD SGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGQVSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVS
400 410 420 430 440 450
490 500 510 520 530 540
pF1KSD PTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTFELTNLLNHPDHYVETENIQHLTDPTLAHVDRISETRKLSMGSDDAAYTQALLVHQKA
460 470 480 490 500 510
550 560 570 580 590 600
pF1KSD RMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQL
520 530 540 550 560 570
610 620 630 640 650 660
pF1KSD QIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDTED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIKTPKTQDTED
580 590 600 610 620 630
670 680 690
pF1KSD DEGAQWNCTACTFLNHPALIRCEQCEMPRHF
:::::::::::::::::::::::::::::::
NP_001 DEGAQWNCTACTFLNHPALIRCEQCEMPRHF
640 650 660
>>XP_005274541 (OMIM: 300480) PREDICTED: TGF-beta-activa (678 aa)
initn: 1098 init1: 406 opt: 819 Z-score: 469.7 bits: 97.3 E(85289): 2e-19
Smith-Waterman score: 1423; 39.0% identity (62.2% similar) in 754 aa overlap (1-692:1-677)
10 20 30 40 50 60
pF1KSD MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDL
:::.: :.:.::::::::.:::.:: :::.:::::::::.::: .:::::..::: :
XP_005 MAQSSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQESSKYLYME--Y
10 20 30 40 50
70 80 90 100 110 120
pF1KSD NFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSE
. ::. .. ::.. .:: ..: . :: : .:...::.:::.:: :::... .. ..
XP_005 HSPDDNRMN--RNRLLHINLGIHSPSSYHPG-DGAQLNGGRTLVHSSSDGHIDPQHAAGK
60 70 80 90 100 110
130 140 150 160
pF1KSD LFQ---QEPQTAPAQVPQ--GFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLS-------
. :::..::: : ..: : :. .. .. . : . :. ....
XP_005 QLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQPSSMQTGMNPSAMQGP
120 130 140 150 160 170
170 180 190 200 210
pF1KSD ---------QQTPRF--NPIMVTLAPNIQTGRNTPTSLHI-HGVPPPVLNSPQGNSIYIR
.. ::. ::: ::.. :. .:...: .:.: .: . .:: .:::::
XP_005 SPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQIPSNLYGSP--GSIYIR
180 190 200 210 220 230
220 230 240 250
pF1KSD PYITTPGGTTRQTQQHSGW-------VSQFN----PMNP-QQVYQPSQPGP---------
:. ... ::: : . : : ... :. : :: ::::: .:
XP_005 Q--TSQSSSGRQTPQSTPWQSSPQGPVPHYSQRPLPVYPHQQNYQPSQYSPKQQQIPQSA
240 250 260 270 280 290
260 270 280 290 300
pF1KSD WTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQP-------PTIHSSGSSQSSA
. . : :. : :: : . : : .:..:: ::.:. : :. ...:: .: :
XP_005 YHSPPPSQCPSPFSSPQHQVQPSQLGHIFMP-PSPSTTPPHPYQQGPPSYQKQGS-HSVA
300 310 320 330 340
310 320 330 340 350 360
pF1KSD HSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTLNRNQPTVY
. :. ...: : : .::: .:: :: ... :: .: ...: ::: ..:
XP_005 YLPYTASSLSKGSMK-KIEITVEPSQRPGTAINRSPSP--------ISNQPSPRNQHSLY
350 360 370 380 390 400
370 380 390 400 410 420
pF1KSD IAASPPNTDELMSR---SQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQ
:..::... :: :::: .:.: . . .:::
XP_005 TATTPPSSSP--SRGISSQPKPPFSVNPV----YITYTQPT-------------------
410 420 430
430 440 450 460 470 480
pF1KSD VSMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTF
::. : . ::::. :: .:::::. . :
XP_005 ---GPSC----TP---------SPSPRVI---PNPTTVFKITVGR-----------ATTE
440 450 460
490 500 510 520 530 540
pF1KSD ELTNLLNHPDHYVETENIQHLTDPTLAHVDRISET--RKLSMGSDDAAYTQALLVHQKAR
.: ::... .. . : :: .. . .. :. :. : :::: :::::::.::.::
XP_005 NLLNLVDQEERSAAPEPIQPISVIPGSGGEKGSHKYQRSSSSGSDDYAYTQALLLHQRAR
470 480 490 500 510 520
550 560 570 580 590 600
pF1KSD MERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQ
:::: ..:...:..:..:::::: ::..: .:::.: . . ::. ::: .::: :::::
XP_005 MERLAKQLKLEKEELERLKSEVNGMEHDLMQRRLRRVSCTTAIPTPEEMTRLRSMNRQLQ
530 540 550 560 570 580
610 620 630 640 650
pF1KSD IDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPV-PPKP--KDQRS-IIKTPKTQD
:..:: ::.::.:.:: .:.:.:..:::::: ::: :::: :..:. ..:.::
XP_005 INVDCTLKEVDLLQSRG-NFDPKAMNNFYDNIE-PGPVVPPKPSKKEHRTGSTQSPRTQP
590 600 610 620 630 640
660 670 680 690
pF1KSD TEDD-EGAQWNCTACTFLNHPALIRCEQCEMPRHF
..: ::: ::: .::::::::: :::::::::.
XP_005 RDEDYEGAPWNCDSCTFLNHPALNRCEQCEMPRYT
650 660 670
>>XP_016884889 (OMIM: 300480) PREDICTED: TGF-beta-activa (721 aa)
initn: 907 init1: 406 opt: 616 Z-score: 358.2 bits: 76.8 E(85289): 3.3e-13
Smith-Waterman score: 1223; 36.3% identity (60.1% similar) in 746 aa overlap (1-687:1-659)
10 20 30 40 50 60
pF1KSD MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDL
:::.: :.:.::::::::.:::.:: :::.:::::::::.::: .:::::..::: :
XP_016 MAQSSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQESSKYLYME--Y
10 20 30 40 50
70 80 90 100 110 120
pF1KSD NFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSE
. ::. .. ::.. .:: ..: . :: : .:...::.:::.:: :::... .. ..
XP_016 HSPDDNRMN--RNRLLHINLGIHSPSSYHPG-DGAQLNGGRTLVHSSSDGHIDPQHAAGK
60 70 80 90 100 110
130 140 150 160
pF1KSD LFQ---QEPQTAPAQVPQ--GFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLS-------
. :::..::: : ..: : :. .. .. . : . :. ....
XP_016 QLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQPSSMQTGMNPSAMQGP
120 130 140 150 160 170
170 180 190 200 210
pF1KSD ---------QQTPRF--NPIMVTLAPNIQTGRNTPTSLHI-HGVPPPVLNSPQGNSIYIR
.. ::. ::: ::.. :. .:...: .:.: .: . .:: .:::::
XP_016 SPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQIPSNLYGSP--GSIYIR
180 190 200 210 220 230
220 230 240 250
pF1KSD PYITTPGGTTRQTQQHSGW-------VSQFN----PMNP-QQVYQPSQPGP---------
:. ... ::: : . : : ... :. : :: ::::: .:
XP_016 Q--TSQSSSGRQTPQSTPWQSSPQGPVPHYSQRPLPVYPHQQNYQPSQYSPKQQQIPQSA
240 250 260 270 280 290
260 270 280 290 300
pF1KSD WTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQP------PTIHSSGSSQSSAH
. . : :. : :: : . : : .:..:: ::.:. : : ... .:.: :.
XP_016 YHSPPPSQCPSPFSSPQHQVQPSQLGHIFMP-PSPSTTPPHPYQQGPPSYQKQGSHSVAY
300 310 320 330 340 350
310 320 330 340 350 360
pF1KSD SQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTLNRNQPTVYI
:. ...: : : .::: .:: :: ... :: .: ...: ::: ..:
XP_016 LPYTASSLSKGSMK-KIEITVEPSQRPGTAINRSPSP--------ISNQPSPRNQHSLYT
360 370 380 390 400
370 380 390 400 410 420
pF1KSD AASPPNTDELMSR---SQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQV
:..::... :: :::: .:.: . . .:::
XP_016 ATTPPSSSP--SRGISSQPKPPFSVNPV----YITYTQPT--------------------
410 420 430
430 440 450 460 470 480
pF1KSD SMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFE
::. : . ::::. :: .:::::. . : .
XP_016 --GPSCT---P----------SPSPRVI---PNPTTVFKITVGR-----------ATTEN
440 450 460
490 500 510 520 530 540
pF1KSD LTNLLNHPDHYVETENIQHLTDPTLAHVDRISET--RKLSMGSDDAAYTQALLVHQKARM
: ::... .. . : :: .. . .. :. :. : :::: :::::::.::.:::
XP_016 LLNLVDQEERSAAPEPIQPISVIPGSGGEKGSHKYQRSSSSGSDDYAYTQALLLHQRARM
470 480 490 500 510 520
550 560 570 580 590 600
pF1KSD ERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQI
::: ..:...:..:..:::::: ::..: .:::.: . . ::. ::: .::: ::::::
XP_016 ERLAKQLKLEKEELERLKSEVNGMEHDLMQRRLRRVSCTTAIPTPEEMTRLRSMNRQLQI
530 540 550 560 570 580
610 620 630 640 650 660
pF1KSD DIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPV-PPKP--KDQRSIIKTPKTQDTE
..:: ::.::.:.:: .:.:.:..:::::: ::: :::: : .::. ..
XP_016 NVDCTLKEVDLLQSRG-NFDPKAMNNFYDNIE-PGPVVPPKPSKKGSRSVAQA-------
590 600 610 620 630
670 680 690
pF1KSD DDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
:.::. .. .: .. .:
XP_016 ---GVQWH-DHSSLQPRPPRLKPSSCLSHLSSWDYRRTPPRPANLCIFCGDRVSPCCPGW
640 650 660 670 680 690
>>XP_016884888 (OMIM: 300480) PREDICTED: TGF-beta-activa (721 aa)
initn: 907 init1: 406 opt: 616 Z-score: 358.2 bits: 76.8 E(85289): 3.3e-13
Smith-Waterman score: 1223; 36.3% identity (60.1% similar) in 746 aa overlap (1-687:1-659)
10 20 30 40 50 60
pF1KSD MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDL
:::.: :.:.::::::::.:::.:: :::.:::::::::.::: .:::::..::: :
XP_016 MAQSSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQESSKYLYME--Y
10 20 30 40 50
70 80 90 100 110 120
pF1KSD NFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSE
. ::. .. ::.. .:: ..: . :: : .:...::.:::.:: :::... .. ..
XP_016 HSPDDNRMN--RNRLLHINLGIHSPSSYHPG-DGAQLNGGRTLVHSSSDGHIDPQHAAGK
60 70 80 90 100 110
130 140 150 160
pF1KSD LFQ---QEPQTAPAQVPQ--GFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLS-------
. :::..::: : ..: : :. .. .. . : . :. ....
XP_016 QLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQPSSMQTGMNPSAMQGP
120 130 140 150 160 170
170 180 190 200 210
pF1KSD ---------QQTPRF--NPIMVTLAPNIQTGRNTPTSLHI-HGVPPPVLNSPQGNSIYIR
.. ::. ::: ::.. :. .:...: .:.: .: . .:: .:::::
XP_016 SPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQIPSNLYGSP--GSIYIR
180 190 200 210 220 230
220 230 240 250
pF1KSD PYITTPGGTTRQTQQHSGW-------VSQFN----PMNP-QQVYQPSQPGP---------
:. ... ::: : . : : ... :. : :: ::::: .:
XP_016 Q--TSQSSSGRQTPQSTPWQSSPQGPVPHYSQRPLPVYPHQQNYQPSQYSPKQQQIPQSA
240 250 260 270 280 290
260 270 280 290 300
pF1KSD WTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQP------PTIHSSGSSQSSAH
. . : :. : :: : . : : .:..:: ::.:. : : ... .:.: :.
XP_016 YHSPPPSQCPSPFSSPQHQVQPSQLGHIFMP-PSPSTTPPHPYQQGPPSYQKQGSHSVAY
300 310 320 330 340 350
310 320 330 340 350 360
pF1KSD SQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTLNRNQPTVYI
:. ...: : : .::: .:: :: ... :: .: ...: ::: ..:
XP_016 LPYTASSLSKGSMK-KIEITVEPSQRPGTAINRSPSP--------ISNQPSPRNQHSLYT
360 370 380 390 400
370 380 390 400 410 420
pF1KSD AASPPNTDELMSR---SQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQV
:..::... :: :::: .:.: . . .:::
XP_016 ATTPPSSSP--SRGISSQPKPPFSVNPV----YITYTQPT--------------------
410 420 430
430 440 450 460 470 480
pF1KSD SMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFE
::. : . ::::. :: .:::::. . : .
XP_016 --GPSCT---P----------SPSPRVI---PNPTTVFKITVGR-----------ATTEN
440 450 460
490 500 510 520 530 540
pF1KSD LTNLLNHPDHYVETENIQHLTDPTLAHVDRISET--RKLSMGSDDAAYTQALLVHQKARM
: ::... .. . : :: .. . .. :. :. : :::: :::::::.::.:::
XP_016 LLNLVDQEERSAAPEPIQPISVIPGSGGEKGSHKYQRSSSSGSDDYAYTQALLLHQRARM
470 480 490 500 510 520
550 560 570 580 590 600
pF1KSD ERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQI
::: ..:...:..:..:::::: ::..: .:::.: . . ::. ::: .::: ::::::
XP_016 ERLAKQLKLEKEELERLKSEVNGMEHDLMQRRLRRVSCTTAIPTPEEMTRLRSMNRQLQI
530 540 550 560 570 580
610 620 630 640 650 660
pF1KSD DIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPV-PPKP--KDQRSIIKTPKTQDTE
..:: ::.::.:.:: .:.:.:..:::::: ::: :::: : .::. ..
XP_016 NVDCTLKEVDLLQSRG-NFDPKAMNNFYDNIE-PGPVVPPKPSKKGSRSVAQA-------
590 600 610 620 630
670 680 690
pF1KSD DDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
:.::. .. .: .. .:
XP_016 ---GVQWH-DHSSLQPRPPRLKPSSCLSHLSSWDYRRTPPRPANLCIFCGDRVSPCCPGW
640 650 660 670 680 690
>>NP_690000 (OMIM: 300480) TGF-beta-activated kinase 1 a (712 aa)
initn: 1101 init1: 406 opt: 612 Z-score: 356.1 bits: 76.4 E(85289): 4.3e-13
Smith-Waterman score: 1329; 37.3% identity (59.3% similar) in 783 aa overlap (1-688:1-707)
10 20 30 40 50 60
pF1KSD MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDL
:::.: :.:.::::::::.:::.:: :::.:::::::::.::: .:::::..::: :
NP_690 MAQSSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQESSKYLYME--Y
10 20 30 40 50
70 80 90 100 110 120
pF1KSD NFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSE
. ::. .. ::.. .:: ..: . :: : .:...::.:::.:: :::... .. ..
NP_690 HSPDDNRMN--RNRLLHINLGIHSPSSYHPG-DGAQLNGGRTLVHSSSDGHIDPQHAAGK
60 70 80 90 100 110
130 140 150 160
pF1KSD LFQ---QEPQTAPAQVPQ--GFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLS-------
. :::..::: : ..: : :. .. .. . : . :. ....
NP_690 QLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQPSSMQTGMNPSAMQGP
120 130 140 150 160 170
170 180 190 200 210
pF1KSD ---------QQTPRF--NPIMVTLAPNIQTGRNTPTSLHI-HGVPPPVLNSPQGNSIYIR
.. ::. ::: ::.. :. .:...: .:.: .: . .:: .:::::
NP_690 SPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQIPSNLYGSP--GSIYIR
180 190 200 210 220 230
220 230 240 250
pF1KSD PYITTPGGTTRQTQQHSGW-------VSQFN----PMNP-QQVYQPSQPGP---------
:. ... ::: : . : : ... :. : :: ::::: .:
NP_690 Q--TSQSSSGRQTPQSTPWQSSPQGPVPHYSQRPLPVYPHQQNYQPSQYSPKQQQIPQSA
240 250 260 270 280 290
260 270 280 290 300
pF1KSD WTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQP------PTIHSSGSSQSSAH
. . : :. : :: : . : : .:..:: ::.:. : : ... .:.: :.
NP_690 YHSPPPSQCPSPFSSPQHQVQPSQLGHIFMP-PSPSTTPPHPYQQGPPSYQKQGSHSVAY
300 310 320 330 340 350
310 320 330 340 350 360
pF1KSD SQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTLNRNQPTVYI
:. ...: : : .::: .:: :: ... :: .: ...: ::: ..:
NP_690 LPYTASSLSKGSMK-KIEITVEPSQRPGTAINRSPSP--------ISNQPSPRNQHSLYT
360 370 380 390 400
370 380 390 400 410 420
pF1KSD AASPPNTDELMSR---SQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQV
:..::... :: :::: .:.: . . .:::
NP_690 ATTPPSSSP--SRGISSQPKPPFSVNPV----YITYTQPT--------------------
410 420 430
430 440 450 460 470 480
pF1KSD SMGPAFIHHHPPKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFE
::. : . ::::. :: .:::::. . : .
NP_690 --GPSCT---P----------SPSPRVI---PNPTTVFKITVGR-----------ATTEN
440 450 460
490 500 510 520 530 540
pF1KSD LTNLLNHPDHYVETENIQHLTDPTLAHVDRISET--RKLSMGSDDAAYTQALLVHQKARM
: ::... .. . : :: .. . .. :. :. : :::: :::::::.::.:::
NP_690 LLNLVDQEERSAAPEPIQPISVIPGSGGEKGSHKYQRSSSSGSDDYAYTQALLLHQRARM
470 480 490 500 510 520
550 560 570 580 590 600
pF1KSD ERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQI
::: ..:...:..:..:::::: ::..: .:::.: . . ::. ::: .::: ::::::
NP_690 ERLAKQLKLEKEELERLKSEVNGMEHDLMQRRLRRVSCTTAIPTPEEMTRLRSMNRQLQI
530 540 550 560 570 580
610 620 630 640 650
pF1KSD DIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPV-PPKP--KDQ----------RSI
..:: ::.::.:.:: .:.:.:..:::::: ::: :::: ::. : :
NP_690 NVDCTLKEVDLLQSRG-NFDPKAMNNFYDNIE-PGPVVPPKPSKKDSSDPCTIERKARRI
590 600 610 620 630 640
660 670 680
pF1KSD -------------------------IKTPKTQDTEDD-EGAQWNCTACTFLNHPALIRCE
..:.:: ..: ::: ::: .::::::::: :::
NP_690 SVTSKVQADIHDTQAAAADEHRTGSTQSPRTQPRDEDYEGAPWNCDSCTFLNHPALNRCE
650 660 670 680 690 700
690
pF1KSD QCEMPRHF
:::
NP_690 QCEMPRYT
710
693 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 02:50:31 2016 done: Thu Nov 3 02:50:33 2016
Total Scan time: 10.850 Total Display time: 0.150
Function used was FASTA [36.3.4 Apr, 2011]