FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0763, 841 aa 1>>>pF1KSDA0763 841 - 841 aa - 841 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.1105+/-0.000417; mu= 7.9221+/- 0.026 mean_var=164.1602+/-32.477, 0's: 0 Z-trim(116.5): 109 B-trim: 0 in 0/54 Lambda= 0.100101 statistics sampled from 27662 (27772) to 27662 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.677), E-opt: 0.2 (0.326), width: 16 Scan time: 10.090 The best scores are: opt bits E(85289) NP_055684 (OMIM: 610166) IQ motif and SEC7 domain- ( 963) 5562 816.1 0 XP_011532614 (OMIM: 610166) PREDICTED: IQ motif an (1006) 5458 801.1 0 XP_011532613 (OMIM: 610166) PREDICTED: IQ motif an (1006) 5458 801.1 0 XP_011532616 (OMIM: 610166) PREDICTED: IQ motif an (1006) 5458 801.1 0 XP_011532615 (OMIM: 610166) PREDICTED: IQ motif an (1006) 5458 801.1 0 NP_001127854 (OMIM: 610166) IQ motif and SEC7 doma (1114) 5458 801.1 0 XP_011532610 (OMIM: 610166) PREDICTED: IQ motif an (1128) 5458 801.2 0 XP_011532609 (OMIM: 610166) PREDICTED: IQ motif an (1129) 5458 801.2 0 XP_011532608 (OMIM: 610166) PREDICTED: IQ motif an (1129) 5458 801.2 0 XP_011532607 (OMIM: 610166) PREDICTED: IQ motif an (1132) 5458 801.2 0 XP_016863071 (OMIM: 610166) PREDICTED: IQ motif an (1207) 5458 801.2 0 XP_011532606 (OMIM: 610166) PREDICTED: IQ motif an (1222) 5458 801.2 0 XP_011532617 (OMIM: 610166) PREDICTED: IQ motif an ( 814) 5361 787.1 0 NP_001317548 (OMIM: 610166) IQ motif and SEC7 doma ( 814) 5361 787.1 0 XP_011532612 (OMIM: 610166) PREDICTED: IQ motif an (1030) 5361 787.1 0 XP_016863070 (OMIM: 610166) PREDICTED: IQ motif an (1212) 4064 599.9 2.3e-170 XP_011529076 (OMIM: 300522,300551,309530) PREDICTE (1222) 1697 258.0 1.9e-67 NP_055890 (OMIM: 300522,300551,309530) IQ motif an ( 949) 1690 256.9 3e-67 XP_006724646 (OMIM: 300522,300551,309530) PREDICTE (1200) 1691 257.2 3.3e-67 XP_011529075 (OMIM: 300522,300551,309530) PREDICTE (1251) 1691 257.2 3.5e-67 XP_006724643 (OMIM: 300522,300551,309530) PREDICTE (1283) 1691 257.2 3.5e-67 XP_016884849 (OMIM: 300522,300551,309530) PREDICTE (1322) 1691 257.2 3.6e-67 XP_006724647 (OMIM: 300522,300551,309530) PREDICTE (1186) 1690 257.0 3.7e-67 XP_006724645 (OMIM: 300522,300551,309530) PREDICTE (1212) 1690 257.0 3.7e-67 XP_006724644 (OMIM: 300522,300551,309530) PREDICTE (1244) 1690 257.0 3.8e-67 XP_011529079 (OMIM: 300522,300551,309530) PREDICTE (1126) 1689 256.8 3.9e-67 XP_011529078 (OMIM: 300522,300551,309530) PREDICTE (1130) 1689 256.8 3.9e-67 XP_016884848 (OMIM: 300522,300551,309530) PREDICTE (1478) 1691 257.2 4e-67 NP_001104595 (OMIM: 300522,300551,309530) IQ motif (1488) 1691 257.2 4e-67 XP_006724642 (OMIM: 300522,300551,309530) PREDICTE (1520) 1691 257.2 4e-67 NP_056047 (OMIM: 612118) IQ motif and SEC7 domain- ( 759) 1335 205.6 6.9e-52 XP_011519263 (OMIM: 612118) PREDICTED: IQ motif an ( 879) 1335 205.7 7.8e-52 XP_016874800 (OMIM: 612118) PREDICTED: IQ motif an (1041) 1335 205.7 8.9e-52 XP_016874799 (OMIM: 612118) PREDICTED: IQ motif an (1041) 1335 205.7 8.9e-52 XP_011519262 (OMIM: 612118) PREDICTED: IQ motif an (1062) 1335 205.7 9.1e-52 XP_011519261 (OMIM: 612118) PREDICTED: IQ motif an (1062) 1335 205.7 9.1e-52 XP_011519260 (OMIM: 612118) PREDICTED: IQ motif an (1063) 1335 205.7 9.1e-52 NP_001164209 (OMIM: 612118) IQ motif and SEC7 doma (1182) 1335 205.7 9.9e-52 XP_006723536 (OMIM: 602488) PREDICTED: cytohesin-2 ( 394) 565 94.2 1.2e-18 NP_004219 (OMIM: 602488) cytohesin-2 isoform 2 [Ho ( 399) 565 94.2 1.2e-18 NP_059431 (OMIM: 602488) cytohesin-2 isoform 1 [Ho ( 400) 565 94.2 1.2e-18 XP_006723535 (OMIM: 602488) PREDICTED: cytohesin-2 ( 421) 565 94.3 1.3e-18 XP_011523778 (OMIM: 182115) PREDICTED: cytohesin-1 ( 322) 542 90.9 1e-17 XP_011523777 (OMIM: 182115) PREDICTED: cytohesin-1 ( 322) 542 90.9 1e-17 XP_016880827 (OMIM: 182115) PREDICTED: cytohesin-1 ( 338) 542 90.9 1.1e-17 XP_011523779 (OMIM: 182115) PREDICTED: cytohesin-1 ( 339) 542 90.9 1.1e-17 NP_001278947 (OMIM: 182115) cytohesin-1 isoform 3 ( 339) 542 90.9 1.1e-17 NP_001278948 (OMIM: 182115) cytohesin-1 isoform 3 ( 339) 542 90.9 1.1e-17 XP_016880826 (OMIM: 182115) PREDICTED: cytohesin-1 ( 380) 542 90.9 1.2e-17 NP_059430 (OMIM: 182115) cytohesin-1 isoform 2 [Ho ( 397) 542 90.9 1.2e-17 >>NP_055684 (OMIM: 610166) IQ motif and SEC7 domain-cont (963 aa) initn: 5562 init1: 5562 opt: 5562 Z-score: 4350.1 bits: 816.1 E(85289): 0 Smith-Waterman score: 5562; 100.0% identity (100.0% similar) in 841 aa overlap (1-841:123-963) 10 20 30 pF1KSD MLERKYGGRLVTRHAARTIQTAFRQYQMNK :::::::::::::::::::::::::::::: NP_055 KQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNK 100 110 120 130 140 150 40 50 60 70 80 90 pF1KSD NFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSP 160 170 180 190 200 210 100 110 120 130 140 150 pF1KSD ECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALD 220 230 240 250 260 270 160 170 180 190 200 210 pF1KSD AARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 AARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDL 280 290 300 310 320 330 220 230 240 250 260 270 pF1KSD RLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDL 340 350 360 370 380 390 280 290 300 310 320 330 pF1KSD SDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAIN 400 410 420 430 440 450 340 350 360 370 380 390 pF1KSD GSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNS 460 470 480 490 500 510 400 410 420 430 440 450 pF1KSD WDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 WDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQ 520 530 540 550 560 570 460 470 480 490 500 510 pF1KSD MIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFS 580 590 600 610 620 630 520 530 540 550 560 570 pF1KSD QRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDG 640 650 660 670 680 690 580 590 600 610 620 630 pF1KSD EDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRR 700 710 720 730 740 750 640 650 660 670 680 690 pF1KSD LVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQ 760 770 780 790 800 810 700 710 720 730 740 750 pF1KSD VLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRI 820 830 840 850 860 870 760 770 780 790 800 810 pF1KSD ESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEA 880 890 900 910 920 930 820 830 840 pF1KSD GKRGRRSSAGSLESNVEFQPFEPLQPSVLCS ::::::::::::::::::::::::::::::: NP_055 GKRGRRSSAGSLESNVEFQPFEPLQPSVLCS 940 950 960 >>XP_011532614 (OMIM: 610166) PREDICTED: IQ motif and SE (1006 aa) initn: 5458 init1: 5458 opt: 5458 Z-score: 4268.7 bits: 801.1 E(85289): 0 Smith-Waterman score: 5458; 100.0% identity (100.0% similar) in 827 aa overlap (1-827:1-827) 10 20 30 40 50 60 pF1KSD MLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD GPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD FSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD VTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD PSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD HSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD INCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 INCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD ELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD NTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD QKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD DLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD NAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD SRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFEPLQPSVLC ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEGSIISSPHMRRRA 790 800 810 820 830 840 pF1KSD S XP_011 TSTRECPSRPHQTMPNSSSLLGSLFGSKRGKPPPQAHLPSAPALPPPHPPVVLPHLQHSV 850 860 870 880 890 900 >>XP_011532613 (OMIM: 610166) PREDICTED: IQ motif and SE (1006 aa) initn: 5458 init1: 5458 opt: 5458 Z-score: 4268.7 bits: 801.1 E(85289): 0 Smith-Waterman score: 5458; 100.0% identity (100.0% similar) in 827 aa overlap (1-827:1-827) 10 20 30 40 50 60 pF1KSD MLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD GPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD FSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD VTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD PSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD HSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD INCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 INCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD ELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD NTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD QKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD DLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD NAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD SRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFEPLQPSVLC ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEGSIISSPHMRRRA 790 800 810 820 830 840 pF1KSD S XP_011 TSTRECPSRPHQTMPNSSSLLGSLFGSKRGKPPPQAHLPSAPALPPPHPPVVLPHLQHSV 850 860 870 880 890 900 >>XP_011532616 (OMIM: 610166) PREDICTED: IQ motif and SE (1006 aa) initn: 5458 init1: 5458 opt: 5458 Z-score: 4268.7 bits: 801.1 E(85289): 0 Smith-Waterman score: 5458; 100.0% identity (100.0% similar) in 827 aa overlap (1-827:1-827) 10 20 30 40 50 60 pF1KSD MLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD GPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD FSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD VTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD PSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD HSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD INCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 INCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD ELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD NTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD QKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD DLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD NAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD SRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFEPLQPSVLC ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEGSIISSPHMRRRA 790 800 810 820 830 840 pF1KSD S XP_011 TSTRECPSRPHQTMPNSSSLLGSLFGSKRGKPPPQAHLPSAPALPPPHPPVVLPHLQHSV 850 860 870 880 890 900 >>XP_011532615 (OMIM: 610166) PREDICTED: IQ motif and SE (1006 aa) initn: 5458 init1: 5458 opt: 5458 Z-score: 4268.7 bits: 801.1 E(85289): 0 Smith-Waterman score: 5458; 100.0% identity (100.0% similar) in 827 aa overlap (1-827:1-827) 10 20 30 40 50 60 pF1KSD MLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLERKYGGRLVTRHAARTIQTAFRQYQMNKNFERLRSSMSENRMSRRIVLSNMRMQFSFE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD GPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPEKVHSSYFEGKQVSVTNDGSQLGALVSPECGDLSEPTTLKSPAPSSDFADAITELEDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD FSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSRQVKSLAESIDDALNCRSLHTEEAPALDAARARDTEPQTALHGMDHRKLDEMTASYSD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD VTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTLYIDEEELSPPLPLSQAGDRPSSTESDLRLRAGGAAPDYWALAHKEDKADTDTSCRST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD PSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSLERQEQRLRVEHLPLLTIEPPSDSSVDLSDRSERGSLKRQSAYERSLGGQQGSPKHGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD HSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSGAPKSLPREEPELRPRPPRPLDSHLAINGSANRQSKSESDYSDGDNDSINSTSNSNDT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD INCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 INCSSESSSRDSLREQTLSKQTYHKEARNSWDSPAFSNDVIRKRHYRIGLNLFNKKPEKG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSTM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD ELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCICNPGVVRQFRNPDTIFILAFAIILL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD NTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPREMLMGIYERIRKRELKTNEDHVSQV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD QKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKVEKLIVGKKPIGSLHPGLGCVLSLPHRRLVCYCRLFEVPDPNKPQKLGLHQREIFLFN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD DLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLVVTKIFQKKKNSVTYSFRQSFSLYGMQVLLFENQYYPNGIRLTSSVPGADIKVLINF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD NAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NAPNPQDRKKFTDDLRESIAEVQEMEKHRIESELEKQKGVVRPSMSQCSSLKKESGNGTL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD SRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEFQPFEPLQPSVLC ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRACLDDSYASGEGLKRSALSSSLRDLSEAGKRGRRSSAGSLESNVEGSIISSPHMRRRA 790 800 810 820 830 840 pF1KSD S XP_011 TSTRECPSRPHQTMPNSSSLLGSLFGSKRGKPPPQAHLPSAPALPPPHPPVVLPHLQHSV 850 860 870 880 890 900 >>NP_001127854 (OMIM: 610166) IQ motif and SEC7 domain-c (1114 aa) initn: 5458 init1: 5458 opt: 5458 Z-score: 4268.1 bits: 801.1 E(85289): 0 Smith-Waterman score: 5458; 100.0% identity (100.0% similar) in 827 aa overlap (1-827:109-935) 10 20 30 pF1KSD MLERKYGGRLVTRHAARTIQTAFRQYQMNK :::::::::::::::::::::::::::::: NP_001 KQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNK 80 90 100 110 120 130 40 50 60 70 80 90 pF1KSD NFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSP 140 150 160 170 180 190 100 110 120 130 140 150 pF1KSD ECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALD 200 210 220 230 240 250 160 170 180 190 200 210 pF1KSD AARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDL 260 270 280 290 300 310 220 230 240 250 260 270 pF1KSD RLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDL 320 330 340 350 360 370 280 290 300 310 320 330 pF1KSD SDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAIN 380 390 400 410 420 430 340 350 360 370 380 390 pF1KSD GSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNS 440 450 460 470 480 490 400 410 420 430 440 450 pF1KSD WDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQ 500 510 520 530 540 550 460 470 480 490 500 510 pF1KSD MIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFS 560 570 580 590 600 610 520 530 540 550 560 570 pF1KSD QRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDG 620 630 640 650 660 670 580 590 600 610 620 630 pF1KSD EDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRR 680 690 700 710 720 730 640 650 660 670 680 690 pF1KSD LVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQ 740 750 760 770 780 790 700 710 720 730 740 750 pF1KSD VLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRI 800 810 820 830 840 850 760 770 780 790 800 810 pF1KSD ESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEA 860 870 880 890 900 910 820 830 840 pF1KSD GKRGRRSSAGSLESNVEFQPFEPLQPSVLCS ::::::::::::::::: NP_001 GKRGRRSSAGSLESNVEGSIISSPHMRRRATSTRECPSRPHQTMPNSSSLLGSLFGSKRG 920 930 940 950 960 970 >>XP_011532610 (OMIM: 610166) PREDICTED: IQ motif and SE (1128 aa) initn: 5458 init1: 5458 opt: 5458 Z-score: 4268.0 bits: 801.2 E(85289): 0 Smith-Waterman score: 5458; 100.0% identity (100.0% similar) in 827 aa overlap (1-827:123-949) 10 20 30 pF1KSD MLERKYGGRLVTRHAARTIQTAFRQYQMNK :::::::::::::::::::::::::::::: XP_011 KQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNK 100 110 120 130 140 150 40 50 60 70 80 90 pF1KSD NFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSP 160 170 180 190 200 210 100 110 120 130 140 150 pF1KSD ECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALD 220 230 240 250 260 270 160 170 180 190 200 210 pF1KSD AARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDL 280 290 300 310 320 330 220 230 240 250 260 270 pF1KSD RLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDL 340 350 360 370 380 390 280 290 300 310 320 330 pF1KSD SDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAIN 400 410 420 430 440 450 340 350 360 370 380 390 pF1KSD GSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNS 460 470 480 490 500 510 400 410 420 430 440 450 pF1KSD WDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQ 520 530 540 550 560 570 460 470 480 490 500 510 pF1KSD MIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFS 580 590 600 610 620 630 520 530 540 550 560 570 pF1KSD QRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDG 640 650 660 670 680 690 580 590 600 610 620 630 pF1KSD EDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRR 700 710 720 730 740 750 640 650 660 670 680 690 pF1KSD LVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQ 760 770 780 790 800 810 700 710 720 730 740 750 pF1KSD VLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRI 820 830 840 850 860 870 760 770 780 790 800 810 pF1KSD ESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEA 880 890 900 910 920 930 820 830 840 pF1KSD GKRGRRSSAGSLESNVEFQPFEPLQPSVLCS ::::::::::::::::: XP_011 GKRGRRSSAGSLESNVEGSIISSPHMRRRATSTRECPSRPHQTMPNSSSLLGSLFGSKRG 940 950 960 970 980 990 >>XP_011532609 (OMIM: 610166) PREDICTED: IQ motif and SE (1129 aa) initn: 5458 init1: 5458 opt: 5458 Z-score: 4268.0 bits: 801.2 E(85289): 0 Smith-Waterman score: 5458; 100.0% identity (100.0% similar) in 827 aa overlap (1-827:124-950) 10 20 30 pF1KSD MLERKYGGRLVTRHAARTIQTAFRQYQMNK :::::::::::::::::::::::::::::: XP_011 KQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNK 100 110 120 130 140 150 40 50 60 70 80 90 pF1KSD NFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSP 160 170 180 190 200 210 100 110 120 130 140 150 pF1KSD ECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALD 220 230 240 250 260 270 160 170 180 190 200 210 pF1KSD AARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDL 280 290 300 310 320 330 220 230 240 250 260 270 pF1KSD RLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDL 340 350 360 370 380 390 280 290 300 310 320 330 pF1KSD SDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAIN 400 410 420 430 440 450 340 350 360 370 380 390 pF1KSD GSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNS 460 470 480 490 500 510 400 410 420 430 440 450 pF1KSD WDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQ 520 530 540 550 560 570 460 470 480 490 500 510 pF1KSD MIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFS 580 590 600 610 620 630 520 530 540 550 560 570 pF1KSD QRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDG 640 650 660 670 680 690 580 590 600 610 620 630 pF1KSD EDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRR 700 710 720 730 740 750 640 650 660 670 680 690 pF1KSD LVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQ 760 770 780 790 800 810 700 710 720 730 740 750 pF1KSD VLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRI 820 830 840 850 860 870 760 770 780 790 800 810 pF1KSD ESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEA 880 890 900 910 920 930 820 830 840 pF1KSD GKRGRRSSAGSLESNVEFQPFEPLQPSVLCS ::::::::::::::::: XP_011 GKRGRRSSAGSLESNVEGSIISSPHMRRRATSTRECPSRPHQTMPNSSSLLGSLFGSKRG 940 950 960 970 980 990 >>XP_011532608 (OMIM: 610166) PREDICTED: IQ motif and SE (1129 aa) initn: 5458 init1: 5458 opt: 5458 Z-score: 4268.0 bits: 801.2 E(85289): 0 Smith-Waterman score: 5458; 100.0% identity (100.0% similar) in 827 aa overlap (1-827:124-950) 10 20 30 pF1KSD MLERKYGGRLVTRHAARTIQTAFRQYQMNK :::::::::::::::::::::::::::::: XP_011 KQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNK 100 110 120 130 140 150 40 50 60 70 80 90 pF1KSD NFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSP 160 170 180 190 200 210 100 110 120 130 140 150 pF1KSD ECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALD 220 230 240 250 260 270 160 170 180 190 200 210 pF1KSD AARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDL 280 290 300 310 320 330 220 230 240 250 260 270 pF1KSD RLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDL 340 350 360 370 380 390 280 290 300 310 320 330 pF1KSD SDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAIN 400 410 420 430 440 450 340 350 360 370 380 390 pF1KSD GSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNS 460 470 480 490 500 510 400 410 420 430 440 450 pF1KSD WDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQ 520 530 540 550 560 570 460 470 480 490 500 510 pF1KSD MIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFS 580 590 600 610 620 630 520 530 540 550 560 570 pF1KSD QRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDG 640 650 660 670 680 690 580 590 600 610 620 630 pF1KSD EDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRR 700 710 720 730 740 750 640 650 660 670 680 690 pF1KSD LVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQ 760 770 780 790 800 810 700 710 720 730 740 750 pF1KSD VLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRI 820 830 840 850 860 870 760 770 780 790 800 810 pF1KSD ESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEA 880 890 900 910 920 930 820 830 840 pF1KSD GKRGRRSSAGSLESNVEFQPFEPLQPSVLCS ::::::::::::::::: XP_011 GKRGRRSSAGSLESNVEGSIISSPHMRRRATSTRECPSRPHQTMPNSSSLLGSLFGSKRG 940 950 960 970 980 990 >>XP_011532607 (OMIM: 610166) PREDICTED: IQ motif and SE (1132 aa) initn: 5458 init1: 5458 opt: 5458 Z-score: 4268.0 bits: 801.2 E(85289): 0 Smith-Waterman score: 5458; 100.0% identity (100.0% similar) in 827 aa overlap (1-827:127-953) 10 20 30 pF1KSD MLERKYGGRLVTRHAARTIQTAFRQYQMNK :::::::::::::::::::::::::::::: XP_011 KQAEEEAIKRSRSLSESYELSSDLQDKQVEMLERKYGGRLVTRHAARTIQTAFRQYQMNK 100 110 120 130 140 150 40 50 60 70 80 90 pF1KSD NFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NFERLRSSMSENRMSRRIVLSNMRMQFSFEGPEKVHSSYFEGKQVSVTNDGSQLGALVSP 160 170 180 190 200 210 100 110 120 130 140 150 pF1KSD ECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ECGDLSEPTTLKSPAPSSDFADAITELEDAFSRQVKSLAESIDDALNCRSLHTEEAPALD 220 230 240 250 260 270 160 170 180 190 200 210 pF1KSD AARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AARARDTEPQTALHGMDHRKLDEMTASYSDVTLYIDEEELSPPLPLSQAGDRPSSTESDL 280 290 300 310 320 330 220 230 240 250 260 270 pF1KSD RLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLRAGGAAPDYWALAHKEDKADTDTSCRSTPSLERQEQRLRVEHLPLLTIEPPSDSSVDL 340 350 360 370 380 390 280 290 300 310 320 330 pF1KSD SDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDRSERGSLKRQSAYERSLGGQQGSPKHGPHSGAPKSLPREEPELRPRPPRPLDSHLAIN 400 410 420 430 440 450 340 350 360 370 380 390 pF1KSD GSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSANRQSKSESDYSDGDNDSINSTSNSNDTINCSSESSSRDSLREQTLSKQTYHKEARNS 460 470 480 490 500 510 400 410 420 430 440 450 pF1KSD WDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WDSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQ 520 530 540 550 560 570 460 470 480 490 500 510 pF1KSD MIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFS 580 590 600 610 620 630 520 530 540 550 560 570 pF1KSD QRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDG 640 650 660 670 680 690 580 590 600 610 620 630 pF1KSD EDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EDIPREMLMGIYERIRKRELKTNEDHVSQVQKVEKLIVGKKPIGSLHPGLGCVLSLPHRR 700 710 720 730 740 750 640 650 660 670 680 690 pF1KSD LVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVCYCRLFEVPDPNKPQKLGLHQREIFLFNDLLVVTKIFQKKKNSVTYSFRQSFSLYGMQ 760 770 780 790 800 810 700 710 720 730 740 750 pF1KSD VLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLLFENQYYPNGIRLTSSVPGADIKVLINFNAPNPQDRKKFTDDLRESIAEVQEMEKHRI 820 830 840 850 860 870 760 770 780 790 800 810 pF1KSD ESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESELEKQKGVVRPSMSQCSSLKKESGNGTLSRACLDDSYASGEGLKRSALSSSLRDLSEA 880 890 900 910 920 930 820 830 840 pF1KSD GKRGRRSSAGSLESNVEFQPFEPLQPSVLCS ::::::::::::::::: XP_011 GKRGRRSSAGSLESNVEGSIISSPHMRRRATSTRECPSRPHQTMPNSSSLLGSLFGSKRG 940 950 960 970 980 990 841 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 02:59:39 2016 done: Thu Nov 3 02:59:40 2016 Total Scan time: 10.090 Total Display time: 0.240 Function used was FASTA [36.3.4 Apr, 2011]