Result of FASTA (omim) for
pF1KSDA0770
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0770, 875 aa
1>>>pF1KSDA0770 875 - 875 aa - 875 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5458+/-0.000465; mu= 19.8515+/- 0.029
mean_var=76.0725+/-15.107, 0's: 0 Z-trim(109.8): 39 B-trim: 676 in 1/52
Lambda= 0.147048
statistics sampled from 17975 (18001) to 17975 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.567), E-opt: 0.2 (0.211), width: 16
Scan time: 9.480
The best scores are: opt bits E(85289)
NP_056104 (OMIM: 612188) vam6/Vps39-like protein i ( 875) 5841 1249.6 0
XP_016877526 (OMIM: 612188) PREDICTED: vam6/Vps39- ( 860) 5667 1212.7 0
XP_011519706 (OMIM: 612188) PREDICTED: vam6/Vps39- ( 896) 5667 1212.7 0
NP_001288067 (OMIM: 612188) vam6/Vps39-like protei ( 886) 5512 1179.8 0
XP_016877525 (OMIM: 612188) PREDICTED: vam6/Vps39- ( 871) 5338 1142.9 0
XP_011519705 (OMIM: 612188) PREDICTED: vam6/Vps39- ( 907) 5338 1142.9 0
XP_016877527 (OMIM: 612188) PREDICTED: vam6/Vps39- ( 751) 5027 1076.9 0
XP_016877528 (OMIM: 612188) PREDICTED: vam6/Vps39- ( 518) 3403 732.2 1.5e-210
XP_016860828 (OMIM: 606237) PREDICTED: transformin ( 440) 198 52.3 6.1e-06
NP_004248 (OMIM: 606237) transforming growth facto ( 860) 198 52.4 1e-05
NP_001136093 (OMIM: 606237) transforming growth fa ( 860) 198 52.4 1e-05
NP_001315575 (OMIM: 606237) transforming growth fa ( 824) 193 51.4 2.1e-05
>>NP_056104 (OMIM: 612188) vam6/Vps39-like protein isofo (875 aa)
initn: 5841 init1: 5841 opt: 5841 Z-score: 6693.2 bits: 1249.6 E(85289): 0
Smith-Waterman score: 5841; 100.0% identity (100.0% similar) in 875 aa overlap (1-875:1-875)
10 20 30 40 50 60
pF1KSD MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD NFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 NFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD GKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAME
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD ATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD LGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD NDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 NDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD SEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD HLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 HLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD EETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEIS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD SYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD PANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKV
790 800 810 820 830 840
850 860 870
pF1KSD CMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT
:::::::::::::::::::::::::::::::::::
NP_056 CMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT
850 860 870
>>XP_016877526 (OMIM: 612188) PREDICTED: vam6/Vps39-like (860 aa)
initn: 5667 init1: 5667 opt: 5667 Z-score: 6493.8 bits: 1212.7 E(85289): 0
Smith-Waterman score: 5667; 100.0% identity (100.0% similar) in 850 aa overlap (1-850:1-850)
10 20 30 40 50 60
pF1KSD MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD NFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD GKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAME
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD ATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD LGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD NDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD SEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD HLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD EETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEIS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD SYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD PANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKV
790 800 810 820 830 840
850 860 870
pF1KSD CMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT
::::::::::
XP_016 CMVCKKKIGNREGEHGCWLS
850 860
>>XP_011519706 (OMIM: 612188) PREDICTED: vam6/Vps39-like (896 aa)
initn: 5667 init1: 5667 opt: 5667 Z-score: 6493.5 bits: 1212.7 E(85289): 0
Smith-Waterman score: 5667; 100.0% identity (100.0% similar) in 850 aa overlap (1-850:1-850)
10 20 30 40 50 60
pF1KSD MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVGCNRFEVTLEKSNK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD NFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLFTCDLQHTETGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYYLIRVD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD GKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDIPVAME
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASNHFVWRLIPVPM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD ATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQKRFDESMQVFAK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD LGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYLTQKRSQLVKKL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD NDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD SEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTVQYLQHLGTENL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD HLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD EETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEIS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD SYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD PANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKV
790 800 810 820 830 840
850 860 870
pF1KSD CMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT
::::::::::
XP_011 CMVCKKKIGNRRCRCQRSGHLEAVLTPKPFSSLQCICKIPQWSGRPLLLFQRGKPS
850 860 870 880 890
>>NP_001288067 (OMIM: 612188) vam6/Vps39-like protein is (886 aa)
initn: 5819 init1: 5512 opt: 5512 Z-score: 6315.9 bits: 1179.8 E(85289): 0
Smith-Waterman score: 5801; 98.6% identity (98.8% similar) in 886 aa overlap (1-875:1-886)
10 20 30 40
pF1KSD MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDV-----------GCN
:::::::::::::::::::::::::::::::::::::::::::::: .::
NP_001 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN
10 20 30 40 50 60
50 60 70 80 90 100
pF1KSD RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF
70 80 90 100 110 120
110 120 130 140 150 160
pF1KSD TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG
130 140 150 160 170 180
170 180 190 200 210 220
pF1KSD FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA
190 200 210 220 230 240
230 240 250 260 270 280
pF1KSD LNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASN
250 260 270 280 290 300
290 300 310 320 330 340
pF1KSD HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK
310 320 330 340 350 360
350 360 370 380 390 400
pF1KSD RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYL
370 380 390 400 410 420
410 420 430 440 450 460
pF1KSD TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL
430 440 450 460 470 480
470 480 490 500 510 520
pF1KSD RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV
490 500 510 520 530 540
530 540 550 560 570 580
pF1KSD QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLA
550 560 570 580 590 600
590 600 610 620 630 640
pF1KSD IPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEY
610 620 630 640 650 660
650 660 670 680 690 700
pF1KSD RQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAE
670 680 690 700 710 720
710 720 730 740 750 760
pF1KSD EYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHS
730 740 750 760 770 780
770 780 790 800 810 820
pF1KSD KLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ
790 800 810 820 830 840
830 840 850 860 870
pF1KSD QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT
850 860 870 880
>>XP_016877525 (OMIM: 612188) PREDICTED: vam6/Vps39-like (871 aa)
initn: 5645 init1: 5338 opt: 5338 Z-score: 6116.5 bits: 1142.9 E(85289): 0
Smith-Waterman score: 5627; 98.6% identity (98.7% similar) in 861 aa overlap (1-850:1-861)
10 20 30 40
pF1KSD MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDV-----------GCN
:::::::::::::::::::::::::::::::::::::::::::::: .::
XP_016 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN
10 20 30 40 50 60
50 60 70 80 90 100
pF1KSD RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF
70 80 90 100 110 120
110 120 130 140 150 160
pF1KSD TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG
130 140 150 160 170 180
170 180 190 200 210 220
pF1KSD FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA
190 200 210 220 230 240
230 240 250 260 270 280
pF1KSD LNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASN
250 260 270 280 290 300
290 300 310 320 330 340
pF1KSD HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK
310 320 330 340 350 360
350 360 370 380 390 400
pF1KSD RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYL
370 380 390 400 410 420
410 420 430 440 450 460
pF1KSD TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL
430 440 450 460 470 480
470 480 490 500 510 520
pF1KSD RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV
490 500 510 520 530 540
530 540 550 560 570 580
pF1KSD QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLA
550 560 570 580 590 600
590 600 610 620 630 640
pF1KSD IPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEY
610 620 630 640 650 660
650 660 670 680 690 700
pF1KSD RQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAE
670 680 690 700 710 720
710 720 730 740 750 760
pF1KSD EYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHS
730 740 750 760 770 780
770 780 790 800 810 820
pF1KSD KLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ
790 800 810 820 830 840
830 840 850 860 870
pF1KSD QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT
:::::::::::::::::::::
XP_016 QVKCIITEEKVCMVCKKKIGNREGEHGCWLS
850 860 870
>>XP_011519705 (OMIM: 612188) PREDICTED: vam6/Vps39-like (907 aa)
initn: 5645 init1: 5338 opt: 5338 Z-score: 6116.3 bits: 1142.9 E(85289): 0
Smith-Waterman score: 5627; 98.6% identity (98.7% similar) in 861 aa overlap (1-850:1-861)
10 20 30 40
pF1KSD MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDV-----------GCN
:::::::::::::::::::::::::::::::::::::::::::::: .::
XP_011 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCN
10 20 30 40 50 60
50 60 70 80 90 100
pF1KSD RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGASLF
70 80 90 100 110 120
110 120 130 140 150 160
pF1KSD TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVG
130 140 150 160 170 180
170 180 190 200 210 220
pF1KSD FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCA
190 200 210 220 230 240
230 240 250 260 270 280
pF1KSD LNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSNIIYVASN
250 260 270 280 290 300
290 300 310 320 330 340
pF1KSD HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFNLFCQK
310 320 330 340 350 360
350 360 370 380 390 400
pF1KSD RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEKAHLALIDYL
370 380 390 400 410 420
410 420 430 440 450 460
pF1KSD TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLL
430 440 450 460 470 480
470 480 490 500 510 520
pF1KSD RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERTV
490 500 510 520 530 540
530 540 550 560 570 580
pF1KSD QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLA
550 560 570 580 590 600
590 600 610 620 630 640
pF1KSD IPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEY
610 620 630 640 650 660
650 660 670 680 690 700
pF1KSD RQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAE
670 680 690 700 710 720
710 720 730 740 750 760
pF1KSD EYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHS
730 740 750 760 770 780
770 780 790 800 810 820
pF1KSD KLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ
790 800 810 820 830 840
830 840 850 860 870
pF1KSD QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPADT
:::::::::::::::::::::
XP_011 QVKCIITEEKVCMVCKKKIGNRRCRCQRSGHLEAVLTPKPFSSLQCICKIPQWSGRPLLL
850 860 870 880 890 900
>>XP_016877527 (OMIM: 612188) PREDICTED: vam6/Vps39-like (751 aa)
initn: 5027 init1: 5027 opt: 5027 Z-score: 5760.9 bits: 1076.9 E(85289): 0
Smith-Waterman score: 5027; 100.0% identity (100.0% similar) in 751 aa overlap (125-875:1-751)
100 110 120 130 140 150
pF1KSD QQITTVSKAKGASLFTCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPD
::::::::::::::::::::::::::::::
XP_016 MCVAVKKKLQLYFWKDREFHELQGDFSVPD
10 20 30
160 170 180 190 200 210
pF1KSD VPKSMAWCENSICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPKSMAWCENSICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDL
40 50 60 70 80 90
220 230 240 250 260 270
pF1KSD TVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVVLNEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPR
100 110 120 130 140 150
280 290 300 310 320 330
pF1KSD FITSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FITSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQI
160 170 180 190 200 210
340 350 360 370 380 390
pF1KSD HHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLS
220 230 240 250 260 270
400 410 420 430 440 450
pF1KSD GAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLL
280 290 300 310 320 330
460 470 480 490 500 510
pF1KSD KCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQ
340 350 360 370 380 390
520 530 540 550 560 570
pF1KSD SKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPR
400 410 420 430 440 450
580 590 600 610 620 630
pF1KSD DRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGK
460 470 480 490 500 510
640 650 660 670 680 690
pF1KSD TPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQA
520 530 540 550 560 570
700 710 720 730 740 750
pF1KSD LFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPK
580 590 600 610 620 630
760 770 780 790 800 810
pF1KSD ANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLL
640 650 660 670 680 690
820 830 840 850 860 870
pF1KSD HAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPAD
700 710 720 730 740 750
pF1KSD T
:
XP_016 T
>>XP_016877528 (OMIM: 612188) PREDICTED: vam6/Vps39-like (518 aa)
initn: 3403 init1: 3403 opt: 3403 Z-score: 3901.3 bits: 732.2 E(85289): 1.5e-210
Smith-Waterman score: 3403; 100.0% identity (100.0% similar) in 512 aa overlap (364-875:7-518)
340 350 360 370 380 390
pF1KSD IHHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVL
::::::::::::::::::::::::::::::
XP_016 MFTFHIDPTHVMGLYPDLLPTDYRKQLQYPNPLPVL
10 20 30
400 410 420 430 440 450
pF1KSD SGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTL
40 50 60 70 80 90
460 470 480 490 500 510
pF1KSD LKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVD
100 110 120 130 140 150
520 530 540 550 560 570
pF1KSD QSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLP
160 170 180 190 200 210
580 590 600 610 620 630
pF1KSD RDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAG
220 230 240 250 260 270
640 650 660 670 680 690
pF1KSD KTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQ
280 290 300 310 320 330
700 710 720 730 740 750
pF1KSD ALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEP
340 350 360 370 380 390
760 770 780 790 800 810
pF1KSD KANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNL
400 410 420 430 440 450
820 830 840 850 860 870
pF1KSD LHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFCSKEVNPA
460 470 480 490 500 510
pF1KSD DT
::
XP_016 DT
>>XP_016860828 (OMIM: 606237) PREDICTED: transforming gr (440 aa)
initn: 408 init1: 185 opt: 198 Z-score: 227.7 bits: 52.3 E(85289): 6.1e-06
Smith-Waterman score: 488; 29.5% identity (58.0% similar) in 438 aa overlap (449-875:28-434)
420 430 440 450 460 470
pF1KSD KLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVALVAPLLRLENNHCHI
:::.::: : ... . :: :: : .
XP_016 MAKCKRFLMSYLNEVRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLVTEN-FCLL
10 20 30 40 50
480 490 500 510 520 530
pF1KSD EESEHVLKKAHKYSELIILYEKKGLHEKALQVLV-----DQSKKANSPLKGHERTVQYLQ
.: :.: .:: : .::. .. :.:. : : . .. : : .: :..:
XP_016 TDSAAWLEKHKKYFALGLLYHYNNQDAAAVQLWVNIVNGDVQDSTRSDL--YEYIVDFLT
60 70 80 90 100 110
540 550 560 570 580 590
pF1KSD HLGTENLHLIFSYSVWVLRDFPEDGLKIFTE---DLPEVESLPRDRVLGFLIENFKGLAI
. :.: ...:. :::. : :...::. : . .:. : ... : . :.: .
XP_016 YCLDEEL--VWAYADWVLQKSEEVGVQVFTKRPLDEQQKNSFNPDDIINCLKKYPKAL-V
120 130 140 150 160 170
600 610 620 630 640 650
pF1KSD PYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYR
::::.. . ..:. : :: :.: :... : :: : : : .
XP_016 KYLEHLVIDKRLQKEEYHTHLAVLYLEEV--LLQRASAS---GK-----GAEATET---Q
180 190 200 210
660 670 680 690 700 710
pF1KSD QKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEE
:: .:. :. : :. . :: : :.: :..:.::.:: : :: :.: ::.
XP_016 AKLRRLLQKSDLYRVHFLLERLQGAGLPMESAILHGKLGEHEKALHILVHELQDFAAAED
220 230 240 250 260 270
720 730 740 750 760
pF1KSD YCHKHYD-RNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHS
:: . :. .... .:: .:: : :: :: ::...:. : .
XP_016 YCLWCSEGRDPPHRQQLFHTLLAIYL-----HA-GPTAHELAV------AAVDLLNRHAT
280 290 300 310 320
770 780 790 800 810 820
pF1KSD KLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQ
..:....:..:: . ... . :: ..... . .: :: .: ..: : ... .
XP_016 EFDAAQVLQMLPDTWSVQLLCPFLMGAMRDSIHARRTMQVALGLARSENLIYTYDKMKLK
330 340 350 360 370 380
830 840 850 860 870
pF1KSD QVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFC--SKEVNPADT
. ....:.:..:.. . . .:.::::: .:: : :...::...
XP_016 GSSIQLSDKKLCQICQNPFCEPVFVRYPNGGLVHTHCAASRHTNPSSSSPGTRT
390 400 410 420 430 440
>>NP_004248 (OMIM: 606237) transforming growth factor-be (860 aa)
initn: 487 init1: 185 opt: 198 Z-score: 223.4 bits: 52.4 E(85289): 1e-05
Smith-Waterman score: 807; 25.5% identity (58.8% similar) in 886 aa overlap (12-875:21-854)
10 20 30 40
pF1KSD MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQG---HLLLYRIRKDVGC
.: ..:.:. . : :::.. :.:: . .:
NP_004 MMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KSD NRFEVTLE-KSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSKAKGAS
: .: . . . .:.: .......: .. :. : .:.: . ..:... . . .. :::.
NP_004 ATFTATKQLQRHLGFKKPVNELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARIKGAA
70 80 90 100 110 120
110 120 130 140 150 160
pF1KSD LFTCDLQHTETGEEVLRMCV-AVKKK-LQLYF-WKDREFHELQGDFSVPDVPKSMAWCEN
:. . . . ...:. .::.. .:... ..:: .. . :. . : ..: .
NP_004 TFALNENPVSGDPFCVEVCIISVKRRTIQMFLVYEDRV--QIVKEVSTAEQPLAVAVDGH
130 140 150 160 170
170 180 190 200 210 220
pF1KSD SICVGFKRDYYLIRVDGKGSIKELFP-TGKQLEPLVAPLADGK-VAVGQDDLTVVLNEEG
.:... .: .:. . : ..::: ... :.: .. . . .: : . . :
NP_004 FLCLALTTQY-IIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATVAG
180 190 200 210 220 230
230 240 250 260 270 280
pF1KSD ICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFITSGGSN
: .:. ..:.. .. . ::.::. ... .... . :.. ... ... . .
NP_004 I-SQRAPVHWSENVIGAAVSFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGR
240 250 260 270 280 290
290 300 310 320 330 340
pF1KSD IIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAE-MKDDSDSEKQQQIHH-IKNL
.: ::... :. :.:.:. :::.:: ... : :: ::. . . .:: : ... : .
NP_004 VI-VATSKGVYILVPLPLEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQVMYRRILQQ
300 310 320 330 340 350
350 360 370 380 390 400
pF1KSD YAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPVLSGAELEK
.: : : .: :. ..: . : ....::: ::::. ..: :. :.:..
NP_004 AGFIQFAQLQFLEAKELFRSGQLDVRELISLYPFLLPTSSSFTRSHP---PLHEYADLNQ
360 370 380 390 400 410
410 420 430 440 450 460
pF1KSD AHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHT
. . ... . :.. ::. ...: . .. : . :::.::: : ..
NP_004 LTQGDQEKMAKCKRFLMSYLNE----------VRSTEVANGYK---EDIDTALLKLYAEA
420 430 440 450
470 480 490 500 510
pF1KSD NVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLV-----DQS
. . :: :: : . .: :.: .:: : .::. .. :.:. : : .
NP_004 DHDSLLDLLVTEN-FCLLTDSAAWLEKHKKYFALGLLYHYNNQDAAAVQLWVNIVNGDVQ
460 470 480 490 500 510
520 530 540 550 560 570
pF1KSD KKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTE---DLPEVESL
.. : : .: :..: . :.: ...:. :::. : :...::. : . .:.
NP_004 DSTRSDL--YEYIVDFLTYCLDEEL--VWAYADWVLQKSEEVGVQVFTKRPLDEQQKNSF
520 530 540 550 560 570
580 590 600 610 620 630
pF1KSD PRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPA
: ... : . :.: . ::::.. . ..:. : :: :.: :... . .
NP_004 NPDDIINCLKKYPKAL-VKYLEHLVIDKRLQKEEYHTHLAVLYLEEV--LLQR---ASAS
580 590 600 610 620
640 650 660 670 680 690
pF1KSD GKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERALLLGRMGKHE
:: : : : . :: .:. :. : :. . :: : :.: :..:.::
NP_004 GK-----GAEATET---QAKLRRLLQKSDLYRVHFLLERLQGAGLPMESAILHGKLGEHE
630 640 650 660 670 680
700 710 720 730 740 750
pF1KSD QALFIYVHILKDTRMAEEYCHKHYD-RNKDGNKDVYLSLLRMYLSPPSIHCLGPIKLELL
.:: : :: :.: ::.:: . :. .... .:: .:: : :: ::
NP_004 KALHILVHELQDFAAAEDYCLWCSEGRDPPHRQQLFHTLLAIYL-----HA-GPTAHELA
690 700 710 720 730
760 770 780 790 800 810
pF1KSD EPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLEENAQKKRFNQVLK
::...:. : ...:....:..:: . ... . :: ..... . .: ::
NP_004 V------AAVDLLNRHATEFDAAQVLQMLPDTWSVQLLCPFLMGAMRDSIHARRTMQVAL
740 750 760 770 780
820 830 840 850 860
pF1KSD NLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARYPNGVVVHYFC--SKE
.: ..: : ... . . ....:.:..:.. . . .:.::::: .:: : :..
NP_004 GLARSENLIYTYDKMKLKGSSIQLSDKKLCQICQNPFCEPVFVRYPNGGLVHTHCAASRH
790 800 810 820 830 840
870
pF1KSD VNPADT
.::...
NP_004 TNPSSSSPGTRT
850 860
875 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 03:02:48 2016 done: Thu Nov 3 03:02:49 2016
Total Scan time: 9.480 Total Display time: 0.250
Function used was FASTA [36.3.4 Apr, 2011]