FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0782, 1205 aa 1>>>pF1KSDA0782 1205 - 1205 aa - 1205 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1350+/-0.000939; mu= 18.3739+/- 0.057 mean_var=92.1750+/-18.912, 0's: 0 Z-trim(107.9): 174 B-trim: 222 in 1/52 Lambda= 0.133588 statistics sampled from 9650 (9836) to 9650 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.302), width: 16 Scan time: 5.470 The best scores are: opt bits E(32554) CCDS8217.2 ARAP1 gene_id:116985|Hs108|chr11 (1205) 8099 1572.0 0 CCDS41687.1 ARAP1 gene_id:116985|Hs108|chr11 (1450) 8099 1572.0 0 CCDS44671.1 ARAP1 gene_id:116985|Hs108|chr11 (1133) 4359 851.2 0 CCDS3441.1 ARAP2 gene_id:116984|Hs108|chr4 (1704) 2743 539.8 2.1e-152 CCDS4266.1 ARAP3 gene_id:64411|Hs108|chr5 (1544) 1685 335.9 4.6e-91 CCDS8951.1 AGAP2 gene_id:116986|Hs108|chr12 ( 836) 333 75.2 7.6e-13 CCDS56027.1 ARHGAP23 gene_id:57636|Hs108|chr17 (1491) 335 75.7 9.4e-13 CCDS44932.1 AGAP2 gene_id:116986|Hs108|chr12 (1192) 333 75.3 1e-12 CCDS46127.1 ARHGAP35 gene_id:2909|Hs108|chr19 (1499) 331 74.9 1.6e-12 CCDS46010.1 MYO9B gene_id:4650|Hs108|chr19 (2022) 328 74.4 3.1e-12 CCDS82077.1 ARHGAP44 gene_id:9912|Hs108|chr17 ( 812) 315 71.7 8.3e-12 CCDS7227.1 ARHGAP22 gene_id:58504|Hs108|chr10 ( 698) 313 71.3 9.5e-12 CCDS58081.1 ARHGAP22 gene_id:58504|Hs108|chr10 ( 704) 313 71.3 9.6e-12 CCDS10239.1 MYO9A gene_id:4649|Hs108|chr15 (2548) 318 72.6 1.4e-11 CCDS47297.1 ARHGAP26 gene_id:23092|Hs108|chr5 ( 759) 310 70.7 1.5e-11 CCDS4277.1 ARHGAP26 gene_id:23092|Hs108|chr5 ( 814) 310 70.7 1.6e-11 CCDS19.2 ACAP3 gene_id:116983|Hs108|chr1 ( 834) 309 70.6 1.9e-11 CCDS2184.1 ARHGAP15 gene_id:55843|Hs108|chr2 ( 475) 303 69.3 2.6e-11 CCDS64802.1 AGAP3 gene_id:116988|Hs108|chr7 ( 580) 302 69.1 3.6e-11 CCDS43681.1 AGAP3 gene_id:116988|Hs108|chr7 ( 911) 302 69.2 5.2e-11 CCDS45095.1 ARHGAP5 gene_id:394|Hs108|chr14 (1501) 304 69.7 5.9e-11 CCDS32062.1 ARHGAP5 gene_id:394|Hs108|chr14 (1502) 304 69.7 6e-11 CCDS34025.1 ARHGAP24 gene_id:83478|Hs108|chr4 ( 748) 297 68.2 8.6e-11 CCDS82076.1 ARHGAP44 gene_id:9912|Hs108|chr17 ( 774) 297 68.2 8.8e-11 CCDS45616.1 ARHGAP44 gene_id:9912|Hs108|chr17 ( 818) 297 68.2 9.2e-11 >>CCDS8217.2 ARAP1 gene_id:116985|Hs108|chr11 (1205 aa) initn: 8099 init1: 8099 opt: 8099 Z-score: 8430.6 bits: 1572.0 E(32554): 0 Smith-Waterman score: 8099; 100.0% identity (100.0% similar) in 1205 aa overlap (1-1205:1-1205) 10 20 30 40 50 60 pF1KSD MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD LQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD LCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD RLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 RLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD NERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 NERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD AKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 AKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQ 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD LRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD GDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 GDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD DVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 DVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKAL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD ISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 ISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEE 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD LRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLE 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD ILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 ILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAM 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD LLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSG 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD APETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 APETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELR 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD EWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 EWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLS 1150 1160 1170 1180 1190 1200 pF1KSD LLRNV ::::: CCDS82 LLRNV >>CCDS41687.1 ARAP1 gene_id:116985|Hs108|chr11 (1450 aa) initn: 8099 init1: 8099 opt: 8099 Z-score: 8429.5 bits: 1572.0 E(32554): 0 Smith-Waterman score: 8099; 100.0% identity (100.0% similar) in 1205 aa overlap (1-1205:246-1450) 10 20 30 pF1KSD MTKKEEPPPSRVPRAVRVASLLSEGEELSG :::::::::::::::::::::::::::::: CCDS41 PPKPVRLFPEFDDSDYDEVPEEGPGAPARVMTKKEEPPPSRVPRAVRVASLLSEGEELSG 220 230 240 250 260 270 40 50 60 70 80 90 pF1KSD DDQGDEEEDDHAYEGVPNGGWHTSSLSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 DDQGDEEEDDHAYEGVPNGGWHTSSLSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWLD 280 290 300 310 320 330 100 110 120 130 140 150 pF1KSD KNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKFEVITNNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 KNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKFEVITNNR 340 350 360 370 380 390 160 170 180 190 200 210 pF1KSD TFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDRAGSLELRGFKNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 TFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDRAGSLELRGFKNK 400 410 420 430 440 450 220 230 240 250 260 270 pF1KSD LYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 LYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSEL 460 470 480 490 500 510 280 290 300 310 320 330 pF1KSD EKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 EKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAG 520 530 540 550 560 570 340 350 360 370 380 390 pF1KSD EHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSEALQPSSSPST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 EHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSEALQPSSSPST 580 590 600 610 620 630 400 410 420 430 440 450 pF1KSD RRCHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDLAETQALLGCGAGINCFSGDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 RRCHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDLAETQALLGCGAGINCFSGDP 640 650 660 670 680 690 460 470 480 490 500 510 pF1KSD EAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 EAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTAS 700 710 720 730 740 750 520 530 540 550 560 570 pF1KSD AGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 AGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFE 760 770 780 790 800 810 580 590 600 610 620 630 pF1KSD HTFEVYTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 HTFEVYTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLS 820 830 840 850 860 870 640 650 660 670 680 690 pF1KSD LQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 LQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQ 880 890 900 910 920 930 700 710 720 730 740 750 pF1KSD GERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 GERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKC 940 950 960 970 980 990 760 770 780 790 800 810 pF1KSD GQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 GQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEAS 1000 1010 1020 1030 1040 1050 820 830 840 850 860 870 pF1KSD EIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 EIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLF 1060 1070 1080 1090 1100 1110 880 890 900 910 920 930 pF1KSD QTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQHAGDFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 QTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQHAGDFI 1120 1130 1140 1150 1160 1170 940 950 960 970 980 990 pF1KSD CTVYLEEKKAETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNEREEAERPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 CTVYLEEKKAETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNEREEAERPL 1180 1190 1200 1210 1220 1230 1000 1010 1020 1030 1040 1050 pF1KSD HFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 HFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLP 1240 1250 1260 1270 1280 1290 1060 1070 1080 1090 1100 1110 pF1KSD SGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPIKSLKVYLGVKKKLRPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 SGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPIKSLKVYLGVKKKLRPP 1300 1310 1320 1330 1340 1350 1120 1130 1140 1150 1160 1170 pF1KSD TCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 TCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEV 1360 1370 1380 1390 1400 1410 1180 1190 1200 pF1KSD RLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV ::::::::::::::::::::::::::::::::::: CCDS41 RLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV 1420 1430 1440 1450 >>CCDS44671.1 ARAP1 gene_id:116985|Hs108|chr11 (1133 aa) initn: 4358 init1: 4358 opt: 4359 Z-score: 4535.5 bits: 851.2 E(32554): 0 Smith-Waterman score: 7424; 94.0% identity (94.0% similar) in 1205 aa overlap (1-1205:1-1133) 10 20 30 40 50 60 pF1KSD MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE-- 310 320 330 340 350 370 380 390 400 410 420 pF1KSD LQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKA : CCDS44 -----------------------------------------------------------A 430 440 450 460 470 480 pF1KSD LCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVP 360 370 380 390 400 410 490 500 510 520 530 540 pF1KSD RLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 RLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFE 420 430 440 450 460 470 550 560 570 580 590 600 pF1KSD NERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 NERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCI 480 490 500 510 520 530 610 620 630 640 650 660 pF1KSD AKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 AKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQ 540 550 560 570 580 590 670 680 690 700 710 720 pF1KSD LRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQL 600 610 620 630 640 650 730 740 750 760 770 780 pF1KSD GDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 GDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVD 660 670 680 690 700 710 790 800 810 820 830 840 pF1KSD DVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 DVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKAL 720 730 740 750 760 770 850 860 870 880 890 900 pF1KSD ISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 ISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEE 780 790 800 810 820 830 910 920 930 940 950 960 pF1KSD LRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLE 840 850 860 870 880 890 970 980 990 1000 1010 1020 pF1KSD ILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 ILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAM 900 910 920 930 940 950 1030 1040 1050 1060 1070 1080 pF1KSD LLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSG :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 LLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRS------ 960 970 980 990 1000 1010 1090 1100 1110 1120 1130 1140 pF1KSD APETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELR ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 -----HRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELR 1020 1030 1040 1050 1060 1150 1160 1170 1180 1190 1200 pF1KSD EWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS44 EWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLS 1070 1080 1090 1100 1110 1120 pF1KSD LLRNV ::::: CCDS44 LLRNV 1130 >>CCDS3441.1 ARAP2 gene_id:116984|Hs108|chr4 (1704 aa) initn: 2499 init1: 1026 opt: 2743 Z-score: 2849.7 bits: 539.8 E(32554): 2.1e-152 Smith-Waterman score: 2902; 41.7% identity (70.7% similar) in 1144 aa overlap (84-1203:484-1591) 60 70 80 90 100 110 pF1KSD SSLSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLR .:.::::: :::. ..:::::..: . CCDS34 SSTSGNADSSAVSSQAISPYACFYGASAKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSIS 460 470 480 490 500 510 120 130 140 150 160 170 pF1KSD YFDSNKDAYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAM :....:. ::: .: .. :: : . ::.::::.:..:::.::.:.. ::..:.. : .:. CCDS34 YYNNEKEMYSKGIIPLSAISTVRVQGDNKFEVVTTQRTFVFRVEKEEERNDWISILLNAL 520 530 540 550 560 570 180 190 200 210 220 230 pF1KSD AEQRARARLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGI : .. :.: . :.. : :::::.: :..... :..: : :: .... :. CCDS34 KSQSLTSQ-SQAVVT-------PEKCGYLELRGYKAKIFTVLSGNSVWLCKNEQDFKSGL 580 590 600 610 620 240 250 260 270 280 290 pF1KSD GITFIDMSVGNVKEVDR---RSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTS :::.: :.:.:::.::: .::.. :::: :::.:..: ::..:.::.: .:::.:: CCDS34 GITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDY 630 640 650 660 670 680 300 310 320 330 340 350 pF1KSD EVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRK ::::.:: :: :::: ::.::::::::::::::.:::.::.:: ::::::::: . CCDS34 EVAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDAS 690 700 710 720 730 740 360 370 380 390 400 410 pF1KSD VWTETLIELFLQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPL .:.. :::::. .:: .: :::.:. .: :. .: :. . ::.:::.:. CCDS34 IWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLA 750 760 770 780 790 800 420 430 440 450 460 470 pF1KSD FGNQEELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEF ..:::.:::::::. :. ::.::: :: . : .::: :: ::..:::.::::: CCDS34 SLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQMEF 810 820 830 840 850 860 480 490 500 510 520 pF1KSD LRNNRTTEVPRLD--SMKPLEKHYSVVLPTVSHSGFLYKTASAG-KLLQDRRAREEFSRR : .:. .. :. : : : .. : .. :::.. ::. :: .... :: ... CCDS34 LYHNKFSDFPQHDIHSEGVLSQESS---QSTFLCDFLYQAPSAASKLSSEKKLLEETNKK 870 880 890 900 910 920 530 540 550 560 570 580 pF1KSD WCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTH---GFEHTFEVYTEGERLYL :::: : :::.::....:::: : .:..:::. : . : ::.: .::..: CCDS34 WCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKEDFYLNTGPIFIFEIYLPSERVFL 930 940 950 960 970 980 590 600 610 620 630 640 pF1KSD FGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGS :: :... ..:.. ::: ::: .::.: :.. .:.: :: .:.. ..:::... : CCDS34 FGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKS 990 1000 1010 1020 1030 1040 650 660 670 680 690 pF1KSD ELRAVFPEGPCE-EPLQLRKLQELSI----QGDSENQVLVLVERRRTLYIQGERRLDFMG :. . . . ..::.::::.: :. . .::.:::. :::::.:. .::: CCDS34 SLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDVLLLVEKGRTLYIHGHTKLDFTV 1050 1060 1070 1080 1090 1100 700 710 720 730 740 750 pF1KSD WLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRL : ::.:::.. :..:..:::. .:.:.:: :. ..:: :: . ::.: :. . ..: CCDS34 WHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISEL 1110 1120 1130 1140 1150 1160 760 770 780 790 800 810 pF1KSD LESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKV :::...:::: .:. :.....::...:: :: :. :.:.:. :. : . .:..:.. CCDS34 LESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDALLTKELYPYWISALDTQDDKERI 1170 1180 1190 1200 1210 1220 820 830 840 850 860 870 pF1KSD SRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKA ..: .. :: :::::. :.: ::: :: :. :.::.::::.::. :::: :: . CCDS34 KKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEE 1230 1240 1250 1260 1270 1280 880 890 900 910 920 930 pF1KSD GRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKK :.:::::.:: .: : :...... : . :.: . . ...:::.. ::.:.:. CCDS34 VNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWK----DTQVSQAGDLLIEVYVERKE 1290 1300 1310 1320 1330 940 950 960 970 980 990 pF1KSD AETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLP- . :.. : ::::: .:: .:. . : :. ::: : :: :::::. :.:: CCDS34 PDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVIENEELERPLHYKENVLEQ 1340 1350 1360 1370 1380 1390 1000 1010 1020 1030 1040 1050 pF1KSD ILH--GLGT--DSHLVVKKHQAMEAMLLYLASR--VGDTKHGMMKFREDRSLLGLGLPSG .:. .:. ...::::. . ... . ..: .:. :.:..:..:. : . : .. CCDS34 VLRWSSLAEPGSAYLVVKRFLTADTIK-HCSDRSTLGSIKEGILKIKEEPSKI---LSGN 1400 1410 1420 1430 1440 1450 1060 1070 1080 1090 1100 1110 pF1KSD GFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPIKSLKVYLGVKKKLRPPTC :.::::.: .. : :::.:.:.. : .: . ..:.: : :::::..::: CCDS34 KFQDRYFVLRDGFLFLYKDVKSSK---------H--DKMFSLSSMKFYRGVKKKMKPPTS 1460 1470 1480 1490 1500 1120 1130 1140 1150 1160 1170 pF1KSD WGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEV-R ::.:. .::: .:.::::.. ::.......::. .:: .. .:.. . . CCDS34 WGLTAY--SEKH---HWHLCCDSSRTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPK 1510 1520 1530 1540 1550 1180 1190 1200 pF1KSD LGSVSLIPLR--GSENEMRRSVAAFTADPLSLLRNV .:.. :::.. :. . :... . :. : :: CCDS34 IGGLPLIPIQHEGNATLARKNIESARAE-LERLRLSEKCDKESVDSSLKERASMVAHCLE 1560 1570 1580 1590 1600 1610 CCDS34 HKDDKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPS 1620 1630 1640 1650 1660 1670 >>CCDS4266.1 ARAP3 gene_id:64411|Hs108|chr5 (1544 aa) initn: 2314 init1: 851 opt: 1685 Z-score: 1748.3 bits: 335.9 E(32554): 4.6e-91 Smith-Waterman score: 2492; 38.9% identity (65.7% similar) in 1137 aa overlap (80-1185:286-1359) 50 60 70 80 90 100 pF1KSD GWHTSSLSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDT .::.. .::::: :::.:..:.:.:... CCDS42 STLLSPTLETEETSDDLISPYASFSFTADRLTPLL-SGWLDKLSPQGNYVFQRRFVQFNG 260 270 280 290 300 310 110 120 130 140 150 160 pF1KSD DHLRYFDSNKDAYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQAL : :: :.:: . : : .. : . . :.::.:::..:.:.::.::...: : ..: CCDS42 RSLMYFGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDMWCSTL 320 330 340 350 360 370 170 180 190 200 210 220 pF1KSD QQAMAEQRARARLSSAYLLGVPGSEQPDR---AGSLELRGFKNKLYVAVVGDKVQLYKNL :. . ::: ::: : :: : .: ::::: : :...:. .. :::. CCDS42 QSCLKEQR---------LLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELALYKSE 380 390 400 410 420 230 240 250 260 270 280 pF1KSD EEYHLGIGITFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEA . . ::::: ::... .:.:. ::::: ::.: :::.:.: ...: :.: :..:. CCDS42 QAFSLGIGICFIELQGCSVRETKSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVTET 430 440 450 460 470 480 290 300 310 320 330 340 pF1KSD LSTSEVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLK :: ::::.::. :: :::::. .::::..:: :::::.:::.::.::.:.:::.::: CCDS42 LSDYEVAEKIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQSLK 490 500 510 520 530 540 350 360 370 380 390 400 pF1KSD MDRKVWTETLIELFLQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRR .: .::.. ...::. ::: .:::::...::.:.:.:...:. : . ::: : .:. CCDS42 LDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLFRK 550 560 570 580 590 600 410 420 430 440 450 460 pF1KSD YHPLFGNQEELDKALCAAVTTTDLAETQALLGCGAGINCFSGD----PEAPTPLALAEQA :: . .. .: .::::::. .: .... : : .. : :. : :: CCDS42 PHPQYPDHSQLLQALCAAVARPNLLKNMTQLLC---VEAFEGEEPWFPPAPD-------- 610 620 630 640 650 470 480 490 500 510 520 pF1KSD GQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQD--RRA :. : : : :. :. ...::::: . ..: . ::. CCDS42 GSC--------------PGLLPSDPSPGVYNEVVVRATYSGFLYCSPVSNKAGPSPPRRG 660 670 680 690 700 530 540 550 560 570 pF1KSD REEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAV-PPPDTHG--FEHTFEVYT :. : ::::: ..: .: .: . : . :. ..::::.: ::: : : .::. CCDS42 RDAPPRLWCVLG-AALEMFASENSPEPLSLIQPQDIVCLGVSPPPTDPGDRFPFSFELIL 710 720 730 740 750 580 590 600 610 620 630 pF1KSD EGERLYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEG : :. :: ..:.. . :.. ..: : : ..::. . ::::: .. : CCDS42 AGGRIQHFGTDGADSLEAWTSAVGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTAPAPGL 760 770 780 790 800 810 640 650 660 670 680 pF1KSD WFS----LSGSELRAVFPEGPC----EEPLQLRKLQELSI--QGDSENQV--LVLVERRR :.: : :..: :: :. ..::.:::.:. .:. .. ::::: : CCDS42 WLSGFGLLRGDHLFLCSAPGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGR 820 830 840 850 860 870 690 700 710 720 730 740 pF1KSD TLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEG :::.::: :::: .: .:: ::.. : :.:::.. .:::.:: :....:: :: :: CCDS42 TLYLQGEGRLDFTAWNAAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEG 880 890 900 910 920 930 750 760 770 780 790 800 pF1KSD IYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLT .::: : ... ::: .:.:::::.:. ::. :.::...::::.:.: : . : :. : CCDS42 VYRKGGARARSLRLLAEFRRDARSVKLRPGEHFVEDVTDTLKRFFRELDDPV-TSARLLP 940 950 960 970 980 990 810 820 830 840 850 860 pF1KSD -WLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIV : ::.:. ...... .:.... :: ::: :. .::.::: :: . ::: ..:::.. CCDS42 RWREAAELPQKNQRLEKYKDVIGCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALL 1000 1010 1020 1030 1040 1050 870 880 890 900 910 920 pF1KSD FGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQ :.:..:::::. . ::...::. :. ::..: ... . :.. :. . . . CCDS42 FAPSVFQTDGRGEHEVRVLQELIDGYISVFDIDSDQVAQIDLEVSLITTWKDVQLS---- 1060 1070 1080 1090 1100 1110 930 940 950 960 970 980 pF1KSD HAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNERE .:::.: ::.:.. .. .:: ..:::::: ..:. :... : :. ::. :. CCDS42 QAGDLIMEVYIEQQLPDNCVTLKVSPTLTAEELTNQVLEMRGTAAGM-DLWVTFEIREHG 1120 1130 1140 1150 1160 1170 990 1000 1010 1020 1030 pF1KSD EAERPLHFAEKVLP-ILHGLGT----DSHLVVKKHQAMEAMLLYLASRVGDTKHGMMKFR : ::::: :::: :. .. :..:: .: :. . : . . :... : CCDS42 ELERPLHPKEKVLEQALQWCQLPEPCSASLLLKKVPLAQAGCLFTGIRRESPRVGLLRCR 1180 1190 1200 1210 1220 1230 1040 1050 1060 1070 1080 1090 pF1KSD EDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPIKSLKV :. : :: . :..:.:.: . :: : :: .:..: :.:::... :: CCDS42 EEPPRL-LG---SRFQERFFLLRGRCLLLLKEKKSSKP-----------EREWPLEGAKV 1240 1250 1260 1270 1100 1110 1120 1130 1140 1150 pF1KSD YLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWPSE :::..:::.::: ::::.. ::.. :: : . :. .: ...: .::: : CCDS42 YLGIRKKLKPPTPWGFTLI-----LEKMHLYLSCTDEDEMWDWTTSILKAQHDDQ-QPVV 1280 1290 1300 1310 1320 1330 1160 1170 1180 1190 1200 pF1KSD PSRVSRA-VPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV : : . . . ..:.. :.:.::... CCDS42 LRRHSSSDLARQKFGTMPLLPIRGDDSGATLLSANQTLRRLHNRRTLSMFFPMKSSQGSV 1340 1350 1360 1370 1380 1390 >>CCDS8951.1 AGAP2 gene_id:116986|Hs108|chr12 (836 aa) initn: 332 init1: 216 opt: 333 Z-score: 344.0 bits: 75.2 E(32554): 7.6e-13 Smith-Waterman score: 361; 30.2% identity (59.7% similar) in 248 aa overlap (241-471:511-754) 220 230 240 250 260 270 pF1KSD LYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSEL :.:...: . . . ... . . : : : CCDS89 LSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAASFE 490 500 510 520 530 540 280 290 300 310 pF1KSD EKEQWLEAMQGAIAEALS---TSEVAER------------IWAAAPNRFCADCGAPQPDW :.. :..:... : .:. .:.: : : : : .:.:::::.: : CCDS89 ERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTW 550 560 570 580 590 600 320 330 340 350 360 370 pF1KSD ASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLGNGAGNRFWAAN ::.:: ..:: .:.: ::.::. .:.:::: .: : . : .. .:: ..:: : .. CCDS89 ASLNLGALICIECSGIHRNLGTHLSRVRSLDLDD--WPRELTLVLTAIGNDTANRVWESD 610 620 630 640 650 380 390 400 410 420 430 pF1KSD VPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDLAETQA . . .:: :. ..:::.. . :: ..: : . : ::: . :.: . CCDS89 TRGRAKPSRDSSREERESWIRAKYEQLLF--LAPLSTSEEPLGRQLWAAVQAQDVATVLL 660 670 680 690 700 710 440 450 460 470 480 490 pF1KSD LLGCG--AGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYS ::. . . .. ::. .:: :: . .... ..: CCDS89 LLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYAR 720 730 740 750 760 770 500 510 520 530 540 550 pF1KSD VVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRA CCDS89 QAGSQLCADILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADAPVALV 780 790 800 810 820 830 >>CCDS56027.1 ARHGAP23 gene_id:57636|Hs108|chr17 (1491 aa) initn: 319 init1: 225 opt: 335 Z-score: 342.4 bits: 75.7 E(32554): 9.4e-13 Smith-Waterman score: 345; 25.7% identity (51.2% similar) in 498 aa overlap (439-900:624-1102) 410 420 430 440 450 460 pF1KSD PLFGNQEELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQM : :.: : . .. : . . :. CCDS56 GRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRS 600 610 620 630 640 650 470 480 490 500 510 520 pF1KSD EFLRNNRTTEVPRLDSMKPLEKHYSVVLPTVSHS-----GFLY-KTASAGKLLQDRRARE : .. . :. : ..: . : .. : :.:: : . : . . . CCDS56 FFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLR 660 670 680 690 700 710 530 540 550 560 570 pF1KSD EFSRRWCVLGDGVLSYFENERAVTPN---------GEIRASEIV---CLAVPPPDTHGFE ...: . .: :: ...: : :: .:. . ::. . . CCDS56 QWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRR 720 730 740 750 760 770 580 590 600 610 620 pF1KSD HTFEVYTEGERLYLFGLESAEQAHEWVKCI-----AKAFVPPLAED-LLARDFERLGRLP :.:.. : ::: :. .. :.. : :.. : :.. :... .. .. CCDS56 HVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVS 780 790 800 810 820 830 630 640 650 660 670 680 pF1KSD YKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRKLQELSIQGDSENQVLVLVERR ...: . . . .: .:.: :.. : . . :. . : : . :: CCDS56 HSSGPKADSSPKGSRGLGG--LKSEFLKQSAARGLRTQDLPAGS-KDDSAAA-------P 840 850 860 870 880 690 700 710 720 730 740 pF1KSD RTLYIQGERRLDFMGWLGAIQKAAA-SMGDTLSEQQLGDSD--IPVIVYRCVDYITQCGL .: . : .. . .::: ..: : : : . . .:.:: : . :: CCDS56 KTPW--G------INIIKKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGL 890 900 910 920 930 750 760 770 780 790 800 pF1KSD TSEGIYRKCGQTSKTQRLLESLRQDARSVHLK-EGEQHVDDVSSALKRFLRDLPDGLFTR : :::: :... .. : :.: . ...:. : : .. .:: :: :.: ::. ::: CCDS56 ESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTD 940 950 960 970 980 990 810 820 830 840 850 860 pF1KSD AQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHN . ..::..::: .:.. :.:. :: :.: :..:: . :. :.:. .: CCDS56 DKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRN 1000 1010 1020 1030 1040 1050 870 880 890 900 910 pF1KSD LAIVFGPTLFQTDGQDYKAG--------RVVEDLINHYVVVFSVDEEELRKQREEITAIV ::.:::::: .:. ... ..:: ::.: :: :::. CCDS56 LALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFS-DEEDKGERTPVGDKEP 1060 1070 1080 1090 1100 1110 920 930 940 950 960 970 pF1KSD KMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILDRRNVGIREK CCDS56 QAVPNIEYLLPNIGRTVPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFISAVNR 1120 1130 1140 1150 1160 1170 >>CCDS44932.1 AGAP2 gene_id:116986|Hs108|chr12 (1192 aa) initn: 349 init1: 216 opt: 333 Z-score: 341.8 bits: 75.3 E(32554): 1e-12 Smith-Waterman score: 353; 29.6% identity (59.3% similar) in 253 aa overlap (241-471:862-1110) 220 230 240 250 260 pF1KSD LYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDR--RSFDL---TTPYRIFSFS : :..... . ..:.. .. . . : CCDS44 KQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFE 840 850 860 870 880 890 270 280 290 300 310 pF1KSD ADSELEKEQWLEAMQGAIAEALS---TSEVAER------------IWAAAPNRFCADCGA : : :.. :..:... : .:. .:.: : : : : .:.:::: CCDS44 AASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGA 900 910 920 930 940 950 320 330 340 350 360 370 pF1KSD PQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLGNGAGNR :.: :::.:: ..:: .:.: ::.::. .:.:::: .: : . : .. .:: ..:: CCDS44 PNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDD--WPRELTLVLTAIGNDTANR 960 970 980 990 1000 380 390 400 410 420 430 pF1KSD FWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDL : ... . .:: :. ..:::.. . :: ..: : . : ::: . :. CCDS44 VWESDTRGRAKPSRDSSREERESWIRAKYEQLLF--LAPLSTSEEPLGRQLWAAVQAQDV 1010 1020 1030 1040 1050 1060 440 450 460 470 480 pF1KSD AETQALLGCG--AGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPL : . ::. . . .. ::. .:: :: . .... ..: CCDS44 ATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTA 1070 1080 1090 1100 1110 1120 490 500 510 520 530 540 pF1KSD EKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPN CCDS44 LFYARQAGSQLCADILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADA 1130 1140 1150 1160 1170 1180 >>CCDS46127.1 ARHGAP35 gene_id:2909|Hs108|chr19 (1499 aa) initn: 322 init1: 168 opt: 331 Z-score: 338.2 bits: 74.9 E(32554): 1.6e-12 Smith-Waterman score: 331; 36.2% identity (68.4% similar) in 152 aa overlap (722-873:1258-1408) 700 710 720 730 740 750 pF1KSD ERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCG .. ::... ::..:: ::..::::: : CCDS46 KPKPKPRPSITKATWESNYFGVPLTTVVTPEKPIPIFIERCIEYIEATGLSTEGIYRVSG 1230 1240 1250 1260 1270 1280 760 770 780 790 800 810 pF1KSD QTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASE . :. . : ... :: ... : : . :. :..:.: :. .::: : ... .:: . CCDS46 NKSEMESLQRQFDQD-HNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHK 1290 1300 1310 1320 1330 1340 820 830 840 850 860 870 pF1KSD IEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQ :.:.:.:. .:.: ..: :. . : .:::: :. . .: :. .::.: : :::.. CCDS46 INDREQKLHALKEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMR 1350 1360 1370 1380 1390 1400 880 890 900 910 920 930 pF1KSD TDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQHAGDFIC : CCDS46 PDFSTMDALTATRTYQTIIELFIQQCPFFFYNRPITEPPGARPSSPSAVASTVPFLTSTP 1410 1420 1430 1440 1450 1460 >>CCDS46010.1 MYO9B gene_id:4650|Hs108|chr19 (2022 aa) initn: 306 init1: 187 opt: 328 Z-score: 333.2 bits: 74.4 E(32554): 3.1e-12 Smith-Waterman score: 328; 28.6% identity (69.9% similar) in 206 aa overlap (713-917:1703-1901) 690 700 710 720 730 740 pF1KSD RRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLT :.:. .. ...:... . .... . :: CCDS46 CVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSDK---ASVPIVLEKLLEHVEMHGLY 1680 1690 1700 1710 1720 750 760 770 780 790 800 pF1KSD SEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQ .::.::: : ...:..: ..:. : .:.:.. :. ....::..::.::. :.: :: CCDS46 TEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHA--ITGVLKQWLRELPEPLMTFAQ 1730 1740 1750 1760 1770 1780 810 820 830 840 850 860 pF1KSD RLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLA .:.: :. ...:... .: .:: .:. ... :: :: : . :.:.:. :: CCDS46 YGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALA 1790 1800 1810 1820 1830 1840 870 880 890 900 910 920 pF1KSD IVFGPTLFQT-DGQDYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTAS :.:.: :.. :..: .. ..:... . : . .:..:: . .. : ....: CCDS46 IIFAPCLLRCPDNSDPLTS--MKDVLKITTCVEMLIKEQMRKYKVKMEEISQLEAAESIA 1850 1860 1870 1880 1890 1900 930 940 950 960 970 980 pF1KSD GTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVN CCDS46 FRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGDEDREKEI 1910 1920 1930 1940 1950 1960 1205 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 03:08:14 2016 done: Thu Nov 3 03:08:15 2016 Total Scan time: 5.470 Total Display time: 0.430 Function used was FASTA [36.3.4 Apr, 2011]