Result of FASTA (omim) for
pF1KSDA0842
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0842, 1019 aa
1>>>pF1KSDA0842 1019 - 1019 aa - 1019 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.6072+/-0.000397; mu= 6.6747+/- 0.025
mean_var=192.6076+/-39.082, 0's: 0 Z-trim(118.5): 22 B-trim: 39 in 2/55
Lambda= 0.092414
statistics sampled from 31486 (31508) to 31486 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.712), E-opt: 0.2 (0.369), width: 16
Scan time: 17.170
The best scores are: opt bits E(85289)
NP_055979 (OMIM: 609613) pleckstrin homology domai (1019) 6903 933.8 0
XP_016856246 (OMIM: 609613) PREDICTED: pleckstrin (1032) 6780 917.4 0
XP_005245848 (OMIM: 609613) PREDICTED: pleckstrin ( 816) 5472 742.9 1.6e-213
XP_005245847 (OMIM: 609613) PREDICTED: pleckstrin ( 999) 5330 724.0 9.6e-208
XP_016856247 (OMIM: 609613) PREDICTED: pleckstrin (1012) 5330 724.0 9.7e-208
XP_011523826 (OMIM: 611466,611497) PREDICTED: plec (1056) 240 45.4 0.0019
NP_055613 (OMIM: 611466,611497) pleckstrin homolog (1056) 240 45.4 0.0019
XP_016880940 (OMIM: 611466,611497) PREDICTED: plec (1056) 240 45.4 0.0019
XP_011523825 (OMIM: 611466,611497) PREDICTED: plec (1056) 240 45.4 0.0019
XP_016880941 (OMIM: 611466,611497) PREDICTED: plec ( 967) 223 43.1 0.0087
XP_011523827 (OMIM: 611466,611497) PREDICTED: plec (1005) 223 43.1 0.009
>>NP_055979 (OMIM: 609613) pleckstrin homology domain-co (1019 aa)
initn: 6903 init1: 6903 opt: 6903 Z-score: 4983.9 bits: 933.8 E(85289): 0
Smith-Waterman score: 6903; 100.0% identity (100.0% similar) in 1019 aa overlap (1-1019:1-1019)
10 20 30 40 50 60
pF1KSD MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD HKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYYKPQYLLDFED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 HKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYYKPQYLLDFED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD RLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD LDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD GRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD HHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 HHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD EPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIHV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD FRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDY
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD VSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATM
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD EKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLHY
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD KAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPHA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD FQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFT
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD CHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 CHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELDR
910 920 930 940 950 960
970 980 990 1000 1010
pF1KSD LLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
970 980 990 1000 1010
>>XP_016856246 (OMIM: 609613) PREDICTED: pleckstrin homo (1032 aa)
initn: 6780 init1: 6780 opt: 6780 Z-score: 4895.2 bits: 917.4 E(85289): 0
Smith-Waterman score: 6780; 100.0% identity (100.0% similar) in 999 aa overlap (21-1019:34-1032)
10 20 30 40 50
pF1KSD MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLD
::::::::::::::::::::::::::::::
XP_016 SCIQQVGACMHPSQDGVGRKCAILTPQTPLLQSYFAACEDEIPAIRNHDKVLQRLCEHLD
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD HALLYGLQDLSSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HALLYGLQDLSSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD RLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYY
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD KPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPS
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD VPSTDWEDGDLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPSTDWEDGDLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHT
250 260 270 280 290 300
300 310 320 330 340 350
pF1KSD TSQEKEEAQALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSQEKEEAQALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGD
310 320 330 340 350 360
360 370 380 390 400 410
pF1KSD GDSRNGSPSLGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDSRNGSPSLGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPL
370 380 390 400 410 420
420 430 440 450 460 470
pF1KSD SKVIDQLNGQLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKVIDQLNGQLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVE
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD SPSTVTSGGGHHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSTVTSGGGHHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQ
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD LSLVREGPVSEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSLVREGPVSEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDN
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD NHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVE
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD EAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPP
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD YPSILTDATMEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YPSILTDATMEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEG
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD TITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCR
790 800 810 820 830 840
840 850 860 870 880 890
pF1KSD RANTTDRPHAFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RANTTDRPHAFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCC
850 860 870 880 890 900
900 910 920 930 940 950
pF1KSD LVLTDDRLFTCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVLTDDRLFTCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVI
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KSD YLSCTSELDRLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLSCTSELDRLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCR
970 980 990 1000 1010 1020
pF1KSD GRASRDPWC
:::::::::
XP_016 GRASRDPWC
1030
>>XP_005245848 (OMIM: 609613) PREDICTED: pleckstrin homo (816 aa)
initn: 5472 init1: 5472 opt: 5472 Z-score: 3954.2 bits: 742.9 E(85289): 1.6e-213
Smith-Waterman score: 5472; 99.1% identity (99.4% similar) in 810 aa overlap (210-1019:7-816)
180 190 200 210 220 230
pF1KSD DRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDG
:. . ::::::::::::::::::::::
XP_005 MVAPFASGTEEEAADYDFGDVFPAVPSVPSTDWEDG
10 20 30
240 250 260 270 280 290
pF1KSD DLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQ
40 50 60 70 80 90
300 310 320 330 340 350
pF1KSD ALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPS
100 110 120 130 140 150
360 370 380 390 400 410
pF1KSD LGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNG
160 170 180 190 200 210
420 430 440 450 460 470
pF1KSD QLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGG
220 230 240 250 260 270
480 490 500 510 520 530
pF1KSD GHHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GHHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPV
280 290 300 310 320 330
540 550 560 570 580 590
pF1KSD SEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIH
340 350 360 370 380 390
600 610 620 630 640 650
pF1KSD VFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELD
400 410 420 430 440 450
660 670 680 690 700 710
pF1KSD YVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDAT
460 470 480 490 500 510
720 730 740 750 760 770
pF1KSD MEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLH
520 530 540 550 560 570
780 790 800 810 820 830
pF1KSD YKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPH
580 590 600 610 620 630
840 850 860 870 880 890
pF1KSD AFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLF
640 650 660 670 680 690
900 910 920 930 940 950
pF1KSD TCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELD
700 710 720 730 740 750
960 970 980 990 1000 1010
pF1KSD RLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
760 770 780 790 800 810
>>XP_005245847 (OMIM: 609613) PREDICTED: pleckstrin homo (999 aa)
initn: 5327 init1: 5327 opt: 5330 Z-score: 3850.6 bits: 724.0 E(85289): 9.6e-208
Smith-Waterman score: 6703; 98.0% identity (98.0% similar) in 1019 aa overlap (1-1019:1-999)
10 20 30 40 50 60
pF1KSD MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD HKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYYKPQYLLDFED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYYKPQYLLDFED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD RLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPSVPSTDWEDGD
:::::::::::::::::::::::::::::::::::::: ::
XP_005 RLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSED--------------------GD
190 200 210 220
250 260 270 280 290 300
pF1KSD LTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQA
230 240 250 260 270 280
310 320 330 340 350 360
pF1KSD LDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSL
290 300 310 320 330 340
370 380 390 400 410 420
pF1KSD GRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPLSKVIDQLNGQ
350 360 370 380 390 400
430 440 450 460 470 480
pF1KSD LDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGG
410 420 430 440 450 460
490 500 510 520 530 540
pF1KSD HHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVS
470 480 490 500 510 520
550 560 570 580 590 600
pF1KSD EPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDNNHLLLLMIHV
530 540 550 560 570 580
610 620 630 640 650 660
pF1KSD FRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDY
590 600 610 620 630 640
670 680 690 700 710 720
pF1KSD VSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATM
650 660 670 680 690 700
730 740 750 760 770 780
pF1KSD EKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEGTITKEGMLHY
710 720 730 740 750 760
790 800 810 820 830 840
pF1KSD KAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPHA
770 780 790 800 810 820
850 860 870 880 890 900
pF1KSD FQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFT
830 840 850 860 870 880
910 920 930 940 950 960
pF1KSD CHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELDR
890 900 910 920 930 940
970 980 990 1000 1010
pF1KSD LLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCRGRASRDPWC
950 960 970 980 990
>>XP_016856247 (OMIM: 609613) PREDICTED: pleckstrin homo (1012 aa)
initn: 5327 init1: 5327 opt: 5330 Z-score: 3850.6 bits: 724.0 E(85289): 9.7e-208
Smith-Waterman score: 6580; 98.0% identity (98.0% similar) in 999 aa overlap (21-1019:34-1012)
10 20 30 40 50
pF1KSD MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLD
::::::::::::::::::::::::::::::
XP_016 SCIQQVGACMHPSQDGVGRKCAILTPQTPLLQSYFAACEDEIPAIRNHDKVLQRLCEHLD
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD HALLYGLQDLSSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HALLYGLQDLSSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD RLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLAPYMPDYY
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD KPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDYDFGDVFPAVPS
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSE-------------
190 200 210 220 230
240 250 260 270 280 290
pF1KSD VPSTDWEDGDLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHT
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 -------DGDLTDTVSGPRSTASDLTSSKASTRSPTQRQNPFNEEPAETVSSSDTTPVHT
240 250 260 270 280
300 310 320 330 340 350
pF1KSD TSQEKEEAQALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSQEKEEAQALDPPDACTELEVIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGD
290 300 310 320 330 340
360 370 380 390 400 410
pF1KSD GDSRNGSPSLGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDSRNGSPSLGRDSPDTMLASPQEEGEGPSSTTESSERSEPGLLIPEMKDTSMERLGQPL
350 360 370 380 390 400
420 430 440 450 460 470
pF1KSD SKVIDQLNGQLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKVIDQLNGQLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVE
410 420 430 440 450 460
480 490 500 510 520 530
pF1KSD SPSTVTSGGGHHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSTVTSGGGHHDPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQ
470 480 490 500 510 520
540 550 560 570 580 590
pF1KSD LSLVREGPVSEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSLVREGPVSEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDEGQGSPSEMVHSSEFRVDN
530 540 550 560 570 580
600 610 620 630 640 650
pF1KSD NHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVE
590 600 610 620 630 640
660 670 680 690 700 710
pF1KSD EAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAVSYNELDYVSVGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPP
650 660 670 680 690 700
720 730 740 750 760 770
pF1KSD YPSILTDATMEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YPSILTDATMEKLALAKFVAQESKCEASAVTVRFYGLVHWEDPTDESLGPTPCHCSPPEG
710 720 730 740 750 760
780 790 800 810 820 830
pF1KSD TITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCR
770 780 790 800 810 820
840 850 860 870 880 890
pF1KSD RANTTDRPHAFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RANTTDRPHAFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCC
830 840 850 860 870 880
900 910 920 930 940 950
pF1KSD LVLTDDRLFTCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVLTDDRLFTCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEYCVLEFSQDSQQLLPPWVI
890 900 910 920 930 940
960 970 980 990 1000 1010
pF1KSD YLSCTSELDRLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLSCTSELDRLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLCR
950 960 970 980 990 1000
pF1KSD GRASRDPWC
:::::::::
XP_016 GRASRDPWC
1010
>>XP_011523826 (OMIM: 611466,611497) PREDICTED: pleckstr (1056 aa)
initn: 247 init1: 199 opt: 240 Z-score: 182.7 bits: 45.4 E(85289): 0.0019
Smith-Waterman score: 270; 24.8% identity (49.3% similar) in 499 aa overlap (1-446:9-475)
10 20 30 40 50
pF1KSD MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHA
..: . : ... ::: ::. ... . .. ..: . .: :. .
XP_011 MLSVVENGLDPQAAIPVIKKKLVGSVKALQKQYVSLDT---VVTSEDGDANTMCSALEAV
10 20 30 40 50
60 70 80 90
pF1KSD LLYGLQD----LSSG----------------YWVLVVHFTRREAIKQIEVLQHVATNLGR
...::. .: .: :. :... :...: : : :..::
XP_011 FIHGLHAKHIRAEAGGKRKKSAHQKPLPQPVFWPLLKAVTHKHIISELEHLTFVNTDVGR
60 70 80 90 100 110
100 110 120 130 140 150
pF1KSD SRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFE
:::: ::::.. .: ::.:. .. . ::.:: .::. . .. ..:....:: . ::
XP_011 CRAWLRLALNDGLMECYLKLLLQEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTSLSFE
120 130 140 150 160 170
160 170 180 190 200
pF1KSD LDLDAPYLD---LAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVT----STNL
:. . :. :.: . : :: : :. :.. .:..:.. : ..
XP_011 LSYKSAILNEWTLTPLALSGLCPLSELD-----PLSTSGAELQRKESLDSISHSSGSEDI
180 190 200 210 220 230
210 220 230 240 250
pF1KSD EWDDSA--------IAPSSEDYDFGDVFPAVPSVPSTD---WEDGDLT-DTVSGPRSTAS
: :. .. :: . : .. :. : . :.:. . : : : :
XP_011 EVHHSGHKIRRNQKLTASSLSLDTASSSQLSCSLNSDSCLLQENGSKSPDHCEEPMSCDS
240 250 260 270 280 290
260 270 280 290 300 310
pF1KSD DLTSSKA--STRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQALDPPDACTELE
:: ...: : :: . :.. ...: :.. ::: : . :.: :.
XP_011 DLGTANAEDSDRSLQEVLLEFSKAQVNSV------PTNGLSQETE----IPTPQASLSLH
300 310 320 330 340
320 330 340 350 360 370
pF1KSD VIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSP-DTMLA
: . .. :: : .: .: . : :: . : :: : .
XP_011 ----------GLNTSTYLHCEA-PAEPLPAQAASGTQ-DG-VHVQEPRPQAPSPLDLQQP
350 360 370 380
380 390 400 410 420
pF1KSD SPQEEGEGPSSTTESSER---SEPGLLIPEMKDTSMERL--GQPLSKVIDQLNGQLD---
. :. ::::. . : . :: . .: . .: ..: : . .. :
XP_011 VESTSGQQPSSTVSETAREVGQGNGLQKAQAHDGAGLKLVVSSPTSPKNKSWISEDDFYR
390 400 410 420 430 440
430 440 450 460 470
pF1KSD PST---WCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGG
:: : .. : :.: :.::. :
XP_011 PSREQPLESASDHPIASYR-GTPGSRPGLHRHFSQEPRKNCSLGALDQACVPSPGRRQAQ
450 460 470 480 490 500
>>NP_055613 (OMIM: 611466,611497) pleckstrin homology do (1056 aa)
initn: 247 init1: 199 opt: 240 Z-score: 182.7 bits: 45.4 E(85289): 0.0019
Smith-Waterman score: 270; 24.8% identity (49.3% similar) in 499 aa overlap (1-446:9-475)
10 20 30 40 50
pF1KSD MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHA
..: . : ... ::: ::. ... . .. ..: . .: :. .
NP_055 MLSVVENGLDPQAAIPVIKKKLVGSVKALQKQYVSLDT---VVTSEDGDANTMCSALEAV
10 20 30 40 50
60 70 80 90
pF1KSD LLYGLQD----LSSG----------------YWVLVVHFTRREAIKQIEVLQHVATNLGR
...::. .: .: :. :... :...: : : :..::
NP_055 FIHGLHAKHIRAEAGGKRKKSAHQKPLPQPVFWPLLKAVTHKHIISELEHLTFVNTDVGR
60 70 80 90 100 110
100 110 120 130 140 150
pF1KSD SRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFE
:::: ::::.. .: ::.:. .. . ::.:: .::. . .. ..:....:: . ::
NP_055 CRAWLRLALNDGLMECYLKLLLQEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTSLSFE
120 130 140 150 160 170
160 170 180 190 200
pF1KSD LDLDAPYLD---LAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVT----STNL
:. . :. :.: . : :: : :. :.. .:..:.. : ..
NP_055 LSYKSAILNEWTLTPLALSGLCPLSELD-----PLSTSGAELQRKESLDSISHSSGSEDI
180 190 200 210 220 230
210 220 230 240 250
pF1KSD EWDDSA--------IAPSSEDYDFGDVFPAVPSVPSTD---WEDGDLT-DTVSGPRSTAS
: :. .. :: . : .. :. : . :.:. . : : : :
NP_055 EVHHSGHKIRRNQKLTASSLSLDTASSSQLSCSLNSDSCLLQENGSKSPDHCEEPMSCDS
240 250 260 270 280 290
260 270 280 290 300 310
pF1KSD DLTSSKA--STRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQALDPPDACTELE
:: ...: : :: . :.. ...: :.. ::: : . :.: :.
NP_055 DLGTANAEDSDRSLQEVLLEFSKAQVNSV------PTNGLSQETE----IPTPQASLSLH
300 310 320 330 340
320 330 340 350 360 370
pF1KSD VIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSP-DTMLA
: . .. :: : .: .: . : :: . : :: : .
NP_055 ----------GLNTSTYLHCEA-PAEPLPAQAASGTQ-DG-VHVQEPRPQAPSPLDLQQP
350 360 370 380
380 390 400 410 420
pF1KSD SPQEEGEGPSSTTESSER---SEPGLLIPEMKDTSMERL--GQPLSKVIDQLNGQLD---
. :. ::::. . : . :: . .: . .: ..: : . .. :
NP_055 VESTSGQQPSSTVSETAREVGQGNGLQKAQAHDGAGLKLVVSSPTSPKNKSWISEDDFYR
390 400 410 420 430 440
430 440 450 460 470
pF1KSD PST---WCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGG
:: : .. : :.: :.::. :
NP_055 PSREQPLESASDHPIASYR-GTPGSRPGLHRHFSQEPRKNCSLGALDQACVPSPGRRQAQ
450 460 470 480 490 500
>>XP_016880940 (OMIM: 611466,611497) PREDICTED: pleckstr (1056 aa)
initn: 247 init1: 199 opt: 240 Z-score: 182.7 bits: 45.4 E(85289): 0.0019
Smith-Waterman score: 270; 24.8% identity (49.3% similar) in 499 aa overlap (1-446:9-475)
10 20 30 40 50
pF1KSD MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHA
..: . : ... ::: ::. ... . .. ..: . .: :. .
XP_016 MLSVVENGLDPQAAIPVIKKKLVGSVKALQKQYVSLDT---VVTSEDGDANTMCSALEAV
10 20 30 40 50
60 70 80 90
pF1KSD LLYGLQD----LSSG----------------YWVLVVHFTRREAIKQIEVLQHVATNLGR
...::. .: .: :. :... :...: : : :..::
XP_016 FIHGLHAKHIRAEAGGKRKKSAHQKPLPQPVFWPLLKAVTHKHIISELEHLTFVNTDVGR
60 70 80 90 100 110
100 110 120 130 140 150
pF1KSD SRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFE
:::: ::::.. .: ::.:. .. . ::.:: .::. . .. ..:....:: . ::
XP_016 CRAWLRLALNDGLMECYLKLLLQEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTSLSFE
120 130 140 150 160 170
160 170 180 190 200
pF1KSD LDLDAPYLD---LAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVT----STNL
:. . :. :.: . : :: : :. :.. .:..:.. : ..
XP_016 LSYKSAILNEWTLTPLALSGLCPLSELD-----PLSTSGAELQRKESLDSISHSSGSEDI
180 190 200 210 220 230
210 220 230 240 250
pF1KSD EWDDSA--------IAPSSEDYDFGDVFPAVPSVPSTD---WEDGDLT-DTVSGPRSTAS
: :. .. :: . : .. :. : . :.:. . : : : :
XP_016 EVHHSGHKIRRNQKLTASSLSLDTASSSQLSCSLNSDSCLLQENGSKSPDHCEEPMSCDS
240 250 260 270 280 290
260 270 280 290 300 310
pF1KSD DLTSSKA--STRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQALDPPDACTELE
:: ...: : :: . :.. ...: :.. ::: : . :.: :.
XP_016 DLGTANAEDSDRSLQEVLLEFSKAQVNSV------PTNGLSQETE----IPTPQASLSLH
300 310 320 330 340
320 330 340 350 360 370
pF1KSD VIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSP-DTMLA
: . .. :: : .: .: . : :: . : :: : .
XP_016 ----------GLNTSTYLHCEA-PAEPLPAQAASGTQ-DG-VHVQEPRPQAPSPLDLQQP
350 360 370 380
380 390 400 410 420
pF1KSD SPQEEGEGPSSTTESSER---SEPGLLIPEMKDTSMERL--GQPLSKVIDQLNGQLD---
. :. ::::. . : . :: . .: . .: ..: : . .. :
XP_016 VESTSGQQPSSTVSETAREVGQGNGLQKAQAHDGAGLKLVVSSPTSPKNKSWISEDDFYR
390 400 410 420 430 440
430 440 450 460 470
pF1KSD PST---WCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGG
:: : .. : :.: :.::. :
XP_016 PSREQPLESASDHPIASYR-GTPGSRPGLHRHFSQEPRKNCSLGALDQACVPSPGRRQAQ
450 460 470 480 490 500
>>XP_011523825 (OMIM: 611466,611497) PREDICTED: pleckstr (1056 aa)
initn: 247 init1: 199 opt: 240 Z-score: 182.7 bits: 45.4 E(85289): 0.0019
Smith-Waterman score: 270; 24.8% identity (49.3% similar) in 499 aa overlap (1-446:9-475)
10 20 30 40 50
pF1KSD MEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHA
..: . : ... ::: ::. ... . .. ..: . .: :. .
XP_011 MLSVVENGLDPQAAIPVIKKKLVGSVKALQKQYVSLDT---VVTSEDGDANTMCSALEAV
10 20 30 40 50
60 70 80 90
pF1KSD LLYGLQD----LSSG----------------YWVLVVHFTRREAIKQIEVLQHVATNLGR
...::. .: .: :. :... :...: : : :..::
XP_011 FIHGLHAKHIRAEAGGKRKKSAHQKPLPQPVFWPLLKAVTHKHIISELEHLTFVNTDVGR
60 70 80 90 100 110
100 110 120 130 140 150
pF1KSD SRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFE
:::: ::::.. .: ::.:. .. . ::.:: .::. . .. ..:....:: . ::
XP_011 CRAWLRLALNDGLMECYLKLLLQEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTSLSFE
120 130 140 150 160 170
160 170 180 190 200
pF1KSD LDLDAPYLD---LAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVT----STNL
:. . :. :.: . : :: : :. :.. .:..:.. : ..
XP_011 LSYKSAILNEWTLTPLALSGLCPLSELD-----PLSTSGAELQRKESLDSISHSSGSEDI
180 190 200 210 220 230
210 220 230 240 250
pF1KSD EWDDSA--------IAPSSEDYDFGDVFPAVPSVPSTD---WEDGDLT-DTVSGPRSTAS
: :. .. :: . : .. :. : . :.:. . : : : :
XP_011 EVHHSGHKIRRNQKLTASSLSLDTASSSQLSCSLNSDSCLLQENGSKSPDHCEEPMSCDS
240 250 260 270 280 290
260 270 280 290 300 310
pF1KSD DLTSSKA--STRSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQALDPPDACTELE
:: ...: : :: . :.. ...: :.. ::: : . :.: :.
XP_011 DLGTANAEDSDRSLQEVLLEFSKAQVNSV------PTNGLSQETE----IPTPQASLSLH
300 310 320 330 340
320 330 340 350 360 370
pF1KSD VIRVTKKKKIGKKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSP-DTMLA
: . .. :: : .: .: . : :: . : :: : .
XP_011 ----------GLNTSTYLHCEA-PAEPLPAQAASGTQ-DG-VHVQEPRPQAPSPLDLQQP
350 360 370 380
380 390 400 410 420
pF1KSD SPQEEGEGPSSTTESSER---SEPGLLIPEMKDTSMERL--GQPLSKVIDQLNGQLD---
. :. ::::. . : . :: . .: . .: ..: : . .. :
XP_011 VESTSGQQPSSTVSETAREVGQGNGLQKAQAHDGAGLKLVVSSPTSPKNKSWISEDDFYR
390 400 410 420 430 440
430 440 450 460 470
pF1KSD PST---WCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGG
:: : .. : :.: :.::. :
XP_011 PSREQPLESASDHPIASYR-GTPGSRPGLHRHFSQEPRKNCSLGALDQACVPSPGRRQAQ
450 460 470 480 490 500
>>XP_016880941 (OMIM: 611466,611497) PREDICTED: pleckstr (967 aa)
initn: 246 init1: 198 opt: 223 Z-score: 171.0 bits: 43.1 E(85289): 0.0087
Smith-Waterman score: 251; 26.8% identity (50.0% similar) in 406 aa overlap (74-446:10-386)
50 60 70 80 90 100
pF1KSD RLCEHLDHALLYGLQDLSSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNE
:. :...: : : :..:: :::: ::::.
XP_016 MDWTPRLPSRHIISELEHLTFVNTDVGRCRAWLRLALND
10 20 30
110 120 130 140 150 160
pF1KSD NSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIRFELDLDAPYLD--
. .: ::.:. .. . ::.:: .::. . .. ..:....:: . :::. . :.
XP_016 GLMECYLKLLLQEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTSLSFELSYKSAILNEW
40 50 60 70 80 90
170 180 190 200 210
pF1KSD -LAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVT----STNLEWDDSA-----
:.: . : :: : :. :.. .:..:.. : ..: :.
XP_016 TLTPLALSGLCPLSELD-----PLSTSGAELQRKESLDSISHSSGSEDIEVHHSGHKIRR
100 110 120 130 140 150
220 230 240 250 260
pF1KSD ---IAPSSEDYDFGDVFPAVPSVPSTD---WEDGDLT-DTVSGPRSTASDLTSSKA--ST
.. :: . : .. :. : . :.:. . : : : ::: ...: :
XP_016 NQKLTASSLSLDTASSSQLSCSLNSDSCLLQENGSKSPDHCEEPMSCDSDLGTANAEDSD
160 170 180 190 200 210
270 280 290 300 310 320
pF1KSD RSPTQRQNPFNEEPAETVSSSDTTPVHTTSQEKEEAQALDPPDACTELEVIRVTKKKKIG
:: . :.. ...: :.. ::: : . :.: :. :
XP_016 RSLQEVLLEFSKAQVNSV------PTNGLSQETE----IPTPQASLSLH----------G
220 230 240 250
330 340 350 360 370 380
pF1KSD KKKKSRSDEEASPLHPACSQKKCAKQGDGDSRNGSPSLGRDSP-DTMLASPQEEGEGPSS
. .. :: : .: .: . : :: . : :: : . . :. :::
XP_016 LNTSTYLHCEA-PAEPLPAQAASGTQ-DG-VHVQEPRPQAPSPLDLQQPVESTSGQQPSS
260 270 280 290 300 310
390 400 410 420 430
pF1KSD TTESSER---SEPGLLIPEMKDTSMERL--GQPLSKVIDQLNGQLD---PST---WCSRA
:. . : . :: . .: . .: ..: : . .. : :: : .
XP_016 TVSETAREVGQGNGLQKAQAHDGAGLKLVVSSPTSPKNKSWISEDDFYRPSREQPLESAS
320 330 340 350 360 370
440 450 460 470 480 490
pF1KSD EPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGGHHDPAGLGQP
. : :.: :.::. :
XP_016 DHPIASYR-GTPGSRPGLHRHFSQEPRKNCSLGALDQACVPSPGRRQAQAAPSQGHKSFR
380 390 400 410 420 430
1019 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 18:45:49 2016 done: Thu Nov 3 18:45:52 2016
Total Scan time: 17.170 Total Display time: 0.300
Function used was FASTA [36.3.4 Apr, 2011]