FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0846, 689 aa 1>>>pF1KSDA0846 689 - 689 aa - 689 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3167+/-0.000436; mu= 15.7893+/- 0.027 mean_var=122.6067+/-24.685, 0's: 0 Z-trim(115.5): 363 B-trim: 372 in 2/52 Lambda= 0.115829 statistics sampled from 25561 (26017) to 25561 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.656), E-opt: 0.2 (0.305), width: 16 Scan time: 10.050 The best scores are: opt bits E(85289) XP_016859252 (OMIM: 609531) PREDICTED: ras guanyl- ( 689) 4677 793.4 0 XP_016859251 (OMIM: 609531) PREDICTED: ras guanyl- ( 689) 4677 793.4 0 XP_005264303 (OMIM: 609531) PREDICTED: ras guanyl- ( 689) 4677 793.4 0 NP_056191 (OMIM: 609531) ras guanyl-releasing prot ( 689) 4677 793.4 0 XP_011531048 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 4665 791.4 0 XP_016859248 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 4665 791.4 0 XP_011531049 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 4665 791.4 0 XP_011531050 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 4665 791.4 0 XP_016859250 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 4665 791.4 0 NP_001132960 (OMIM: 609531) ras guanyl-releasing p ( 690) 4665 791.4 0 XP_016859249 (OMIM: 609531) PREDICTED: ras guanyl- ( 690) 4665 791.4 0 NP_733772 (OMIM: 609531) ras guanyl-releasing prot ( 690) 4665 791.4 0 XP_016877349 (OMIM: 603962) PREDICTED: RAS guanyl- ( 749) 2315 398.7 4.1e-110 NP_005730 (OMIM: 603962) RAS guanyl-releasing prot ( 797) 2315 398.8 4.2e-110 XP_011519453 (OMIM: 603962) PREDICTED: RAS guanyl- ( 632) 2235 385.3 3.8e-106 XP_005254171 (OMIM: 603962) PREDICTED: RAS guanyl- ( 746) 2093 361.6 6e-99 NP_722541 (OMIM: 605577,615888) RAS guanyl-releasi ( 609) 2056 355.4 3.7e-97 NP_001092140 (OMIM: 605577,615888) RAS guanyl-rele ( 609) 2056 355.4 3.7e-97 NP_001092141 (OMIM: 605577,615888) RAS guanyl-rele ( 609) 2056 355.4 3.7e-97 XP_011543022 (OMIM: 605577,615888) PREDICTED: RAS ( 610) 2056 355.4 3.7e-97 XP_011543024 (OMIM: 605577,615888) PREDICTED: RAS ( 610) 2056 355.4 3.7e-97 XP_016872573 (OMIM: 605577,615888) PREDICTED: RAS ( 610) 2056 355.4 3.7e-97 XP_011543023 (OMIM: 605577,615888) PREDICTED: RAS ( 610) 2056 355.4 3.7e-97 XP_011543025 (OMIM: 605577,615888) PREDICTED: RAS ( 610) 2056 355.4 3.7e-97 XP_005273764 (OMIM: 605577,615888) PREDICTED: RAS ( 714) 1905 330.2 1.7e-89 XP_011543020 (OMIM: 605577,615888) PREDICTED: RAS ( 715) 1905 330.2 1.7e-89 XP_016872572 (OMIM: 605577,615888) PREDICTED: RAS ( 897) 1905 330.3 2e-89 XP_016872571 (OMIM: 605577,615888) PREDICTED: RAS ( 898) 1905 330.3 2e-89 XP_016872574 (OMIM: 605577,615888) PREDICTED: RAS ( 551) 1851 321.1 7.1e-87 NP_733749 (OMIM: 607320) RAS guanyl-releasing prot ( 673) 1648 287.2 1.3e-76 NP_001305327 (OMIM: 605577,615888) RAS guanyl-rele ( 464) 1629 283.9 9.2e-76 XP_011543027 (OMIM: 605577,615888) PREDICTED: RAS ( 465) 1629 283.9 9.2e-76 XP_016872575 (OMIM: 605577,615888) PREDICTED: RAS ( 465) 1629 283.9 9.2e-76 NP_001139674 (OMIM: 607320) RAS guanyl-releasing p ( 659) 1436 251.8 6.1e-66 NP_001293015 (OMIM: 603962) RAS guanyl-releasing p ( 597) 1421 249.3 3.2e-65 NP_001122074 (OMIM: 603962) RAS guanyl-releasing p ( 762) 1421 249.4 3.9e-65 NP_001139677 (OMIM: 607320) RAS guanyl-releasing p ( 639) 1203 212.9 3.1e-54 NP_001139679 (OMIM: 607320) RAS guanyl-releasing p ( 576) 929 167.0 1.8e-40 NP_001139676 (OMIM: 607320) RAS guanyl-releasing p ( 604) 728 133.5 2.4e-30 NP_001139675 (OMIM: 607320) RAS guanyl-releasing p ( 581) 726 133.1 2.9e-30 NP_001139678 (OMIM: 607320) RAS guanyl-releasing p ( 484) 678 125.0 6.6e-28 XP_016865171 (OMIM: 606614) PREDICTED: ras-specifi (1142) 436 84.9 1.8e-15 NP_008840 (OMIM: 606614) ras-specific guanine nucl (1237) 436 85.0 1.9e-15 NP_722522 (OMIM: 606600) ras-specific guanine nucl ( 489) 397 78.1 9e-14 NP_001139120 (OMIM: 606600) ras-specific guanine n (1257) 397 78.4 1.8e-13 XP_016877945 (OMIM: 606600) PREDICTED: ras-specifi (1260) 397 78.4 1.8e-13 XP_016877944 (OMIM: 606600) PREDICTED: ras-specifi (1270) 397 78.4 1.8e-13 NP_002882 (OMIM: 606600) ras-specific guanine nucl (1273) 397 78.4 1.8e-13 NP_005303 (OMIM: 600303) rap guanine nucleotide ex (1077) 385 76.4 6.5e-13 NP_001291204 (OMIM: 600303) rap guanine nucleotide (1094) 385 76.4 6.5e-13 >>XP_016859252 (OMIM: 609531) PREDICTED: ras guanyl-rele (689 aa) initn: 4677 init1: 4677 opt: 4677 Z-score: 4231.6 bits: 793.4 E(85289): 0 Smith-Waterman score: 4677; 100.0% identity (100.0% similar) in 689 aa overlap (1-689:1-689) 10 20 30 40 50 60 pF1KSD MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TLSLDLYHTEDDIYKLSLVLEPRNSKSPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLSLDLYHTEDDIYKLSLVLEPRNSKSPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD RKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD LACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD SVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVH 610 620 630 640 650 660 670 680 pF1KSD AGVDVVDRGTEFELDQDEGEETRQDGEDG ::::::::::::::::::::::::::::: XP_016 AGVDVVDRGTEFELDQDEGEETRQDGEDG 670 680 >>XP_016859251 (OMIM: 609531) PREDICTED: ras guanyl-rele (689 aa) initn: 4677 init1: 4677 opt: 4677 Z-score: 4231.6 bits: 793.4 E(85289): 0 Smith-Waterman score: 4677; 100.0% identity (100.0% similar) in 689 aa overlap (1-689:1-689) 10 20 30 40 50 60 pF1KSD MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TLSLDLYHTEDDIYKLSLVLEPRNSKSPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLSLDLYHTEDDIYKLSLVLEPRNSKSPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD RKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD LACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD SVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVH 610 620 630 640 650 660 670 680 pF1KSD AGVDVVDRGTEFELDQDEGEETRQDGEDG ::::::::::::::::::::::::::::: XP_016 AGVDVVDRGTEFELDQDEGEETRQDGEDG 670 680 >>XP_005264303 (OMIM: 609531) PREDICTED: ras guanyl-rele (689 aa) initn: 4677 init1: 4677 opt: 4677 Z-score: 4231.6 bits: 793.4 E(85289): 0 Smith-Waterman score: 4677; 100.0% identity (100.0% similar) in 689 aa overlap (1-689:1-689) 10 20 30 40 50 60 pF1KSD MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TLSLDLYHTEDDIYKLSLVLEPRNSKSPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLSLDLYHTEDDIYKLSLVLEPRNSKSPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD RKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD LACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD SVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVH 610 620 630 640 650 660 670 680 pF1KSD AGVDVVDRGTEFELDQDEGEETRQDGEDG ::::::::::::::::::::::::::::: XP_005 AGVDVVDRGTEFELDQDEGEETRQDGEDG 670 680 >>NP_056191 (OMIM: 609531) ras guanyl-releasing protein (689 aa) initn: 4677 init1: 4677 opt: 4677 Z-score: 4231.6 bits: 793.4 E(85289): 0 Smith-Waterman score: 4677; 100.0% identity (100.0% similar) in 689 aa overlap (1-689:1-689) 10 20 30 40 50 60 pF1KSD MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TLSLDLYHTEDDIYKLSLVLEPRNSKSPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 TLSLDLYHTEDDIYKLSLVLEPRNSKSPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD RKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 RKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD LACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD SVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVH 610 620 630 640 650 660 670 680 pF1KSD AGVDVVDRGTEFELDQDEGEETRQDGEDG ::::::::::::::::::::::::::::: NP_056 AGVDVVDRGTEFELDQDEGEETRQDGEDG 670 680 >>XP_011531048 (OMIM: 609531) PREDICTED: ras guanyl-rele (690 aa) initn: 2558 init1: 2558 opt: 4665 Z-score: 4220.7 bits: 791.4 E(85289): 0 Smith-Waterman score: 4665; 99.9% identity (99.9% similar) in 690 aa overlap (1-689:1-690) 10 20 30 40 50 60 pF1KSD MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 310 320 330 340 350 360 370 380 390 400 410 pF1KSD TLSLDLYHTEDDIYKLSLVLEPRNSKS-PTSPTTPNKPVVPLEWALGVMPKPDPTVINKH ::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: XP_011 TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KSD VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK 550 560 570 580 590 600 600 610 620 630 640 650 pF1KSD ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV 610 620 630 640 650 660 660 670 680 pF1KSD HAGVDVVDRGTEFELDQDEGEETRQDGEDG :::::::::::::::::::::::::::::: XP_011 HAGVDVVDRGTEFELDQDEGEETRQDGEDG 670 680 690 >>XP_016859248 (OMIM: 609531) PREDICTED: ras guanyl-rele (690 aa) initn: 2558 init1: 2558 opt: 4665 Z-score: 4220.7 bits: 791.4 E(85289): 0 Smith-Waterman score: 4665; 99.9% identity (99.9% similar) in 690 aa overlap (1-689:1-690) 10 20 30 40 50 60 pF1KSD MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 310 320 330 340 350 360 370 380 390 400 410 pF1KSD TLSLDLYHTEDDIYKLSLVLEPRNSKS-PTSPTTPNKPVVPLEWALGVMPKPDPTVINKH ::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: XP_016 TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KSD VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK 550 560 570 580 590 600 600 610 620 630 640 650 pF1KSD ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV 610 620 630 640 650 660 660 670 680 pF1KSD HAGVDVVDRGTEFELDQDEGEETRQDGEDG :::::::::::::::::::::::::::::: XP_016 HAGVDVVDRGTEFELDQDEGEETRQDGEDG 670 680 690 >>XP_011531049 (OMIM: 609531) PREDICTED: ras guanyl-rele (690 aa) initn: 2558 init1: 2558 opt: 4665 Z-score: 4220.7 bits: 791.4 E(85289): 0 Smith-Waterman score: 4665; 99.9% identity (99.9% similar) in 690 aa overlap (1-689:1-690) 10 20 30 40 50 60 pF1KSD MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 310 320 330 340 350 360 370 380 390 400 410 pF1KSD TLSLDLYHTEDDIYKLSLVLEPRNSKS-PTSPTTPNKPVVPLEWALGVMPKPDPTVINKH ::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: XP_011 TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KSD VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK 550 560 570 580 590 600 600 610 620 630 640 650 pF1KSD ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV 610 620 630 640 650 660 660 670 680 pF1KSD HAGVDVVDRGTEFELDQDEGEETRQDGEDG :::::::::::::::::::::::::::::: XP_011 HAGVDVVDRGTEFELDQDEGEETRQDGEDG 670 680 690 >>XP_011531050 (OMIM: 609531) PREDICTED: ras guanyl-rele (690 aa) initn: 2558 init1: 2558 opt: 4665 Z-score: 4220.7 bits: 791.4 E(85289): 0 Smith-Waterman score: 4665; 99.9% identity (99.9% similar) in 690 aa overlap (1-689:1-690) 10 20 30 40 50 60 pF1KSD MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 310 320 330 340 350 360 370 380 390 400 410 pF1KSD TLSLDLYHTEDDIYKLSLVLEPRNSKS-PTSPTTPNKPVVPLEWALGVMPKPDPTVINKH ::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: XP_011 TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KSD VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK 550 560 570 580 590 600 600 610 620 630 640 650 pF1KSD ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV 610 620 630 640 650 660 660 670 680 pF1KSD HAGVDVVDRGTEFELDQDEGEETRQDGEDG :::::::::::::::::::::::::::::: XP_011 HAGVDVVDRGTEFELDQDEGEETRQDGEDG 670 680 690 >>XP_016859250 (OMIM: 609531) PREDICTED: ras guanyl-rele (690 aa) initn: 2558 init1: 2558 opt: 4665 Z-score: 4220.7 bits: 791.4 E(85289): 0 Smith-Waterman score: 4665; 99.9% identity (99.9% similar) in 690 aa overlap (1-689:1-690) 10 20 30 40 50 60 pF1KSD MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 310 320 330 340 350 360 370 380 390 400 410 pF1KSD TLSLDLYHTEDDIYKLSLVLEPRNSKS-PTSPTTPNKPVVPLEWALGVMPKPDPTVINKH ::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: XP_016 TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KSD VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK 550 560 570 580 590 600 600 610 620 630 640 650 pF1KSD ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV 610 620 630 640 650 660 660 670 680 pF1KSD HAGVDVVDRGTEFELDQDEGEETRQDGEDG :::::::::::::::::::::::::::::: XP_016 HAGVDVVDRGTEFELDQDEGEETRQDGEDG 670 680 690 >>NP_001132960 (OMIM: 609531) ras guanyl-releasing prote (690 aa) initn: 2558 init1: 2558 opt: 4665 Z-score: 4220.7 bits: 791.4 E(85289): 0 Smith-Waterman score: 4665; 99.9% identity (99.9% similar) in 690 aa overlap (1-689:1-690) 10 20 30 40 50 60 pF1KSD MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 310 320 330 340 350 360 370 380 390 400 410 pF1KSD TLSLDLYHTEDDIYKLSLVLEPRNSKS-PTSPTTPNKPVVPLEWALGVMPKPDPTVINKH ::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: NP_001 TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL 490 500 510 520 530 540 540 550 560 570 580 590 pF1KSD VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK 550 560 570 580 590 600 600 610 620 630 640 650 pF1KSD ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV 610 620 630 640 650 660 660 670 680 pF1KSD HAGVDVVDRGTEFELDQDEGEETRQDGEDG :::::::::::::::::::::::::::::: NP_001 HAGVDVVDRGTEFELDQDEGEETRQDGEDG 670 680 690 689 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 03:43:57 2016 done: Thu Nov 3 03:43:59 2016 Total Scan time: 10.050 Total Display time: 0.230 Function used was FASTA [36.3.4 Apr, 2011]