FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0859, 699 aa 1>>>pF1KSDA0859 699 - 699 aa - 699 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8482+/-0.000854; mu= 16.7982+/- 0.051 mean_var=68.8375+/-13.559, 0's: 0 Z-trim(106.5): 21 B-trim: 0 in 0/50 Lambda= 0.154583 statistics sampled from 8988 (8998) to 8988 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.276), width: 16 Scan time: 3.680 The best scores are: opt bits E(32554) CCDS1299.1 METTL13 gene_id:51603|Hs108|chr1 ( 699) 4678 1052.6 0 CCDS1300.1 METTL13 gene_id:51603|Hs108|chr1 ( 613) 4094 922.3 0 CCDS30936.1 METTL13 gene_id:51603|Hs108|chr1 ( 543) 2630 595.8 5.5e-170 CCDS3255.1 ECE2 gene_id:9718|Hs108|chr3 ( 255) 413 101.3 1.9e-21 CCDS3256.2 ECE2 gene_id:9718|Hs108|chr3 ( 883) 367 91.2 7.2e-18 >>CCDS1299.1 METTL13 gene_id:51603|Hs108|chr1 (699 aa) initn: 4678 init1: 4678 opt: 4678 Z-score: 5631.9 bits: 1052.6 E(32554): 0 Smith-Waterman score: 4678; 100.0% identity (100.0% similar) in 699 aa overlap (1-699:1-699) 10 20 30 40 50 60 pF1KSD MNLLPKSSREFGSVDYWEKFFQQRGKKAFEWYGTYLELCGVLHKYIKPREKVLVIGCGNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 MNLLPKSSREFGSVDYWEKFFQQRGKKAFEWYGTYLELCGVLHKYIKPREKVLVIGCGNS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD ELSEQLYDVGYRDIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQMEFPDASFQVVLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 ELSEQLYDVGYRDIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQMEFPDASFQVVLD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD KGTLDAVLTDEEEKTLQQVDRMLAEVGRVLQVGGRYLCISLAQAHILKKAVGHFSREGWM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 KGTLDAVLTDEEEKTLQQVDRMLAEVGRVLQVGGRYLCISLAQAHILKKAVGHFSREGWM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD VRVHQVANSQDQVLEAEPQFSLPVFAFIMTKFRPVPGSALQIFELCAQEQRKPVRLESAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 VRVHQVANSQDQVLEAEPQFSLPVFAFIMTKFRPVPGSALQIFELCAQEQRKPVRLESAE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD RLAEAVQERQQYAWLCSQLRRKARLGSVSLDLCDGDTGEPRYTLHVVDSPTVKPSRDNHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 RLAEAVQERQQYAWLCSQLRRKARLGSVSLDLCDGDTGEPRYTLHVVDSPTVKPSRDNHF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD AIFIIPQGRETEWLFGMDEGRKQLAASAGFRRLITVALHRGQQYESMDHIQAELSARVME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 AIFIIPQGRETEWLFGMDEGRKQLAASAGFRRLITVALHRGQQYESMDHIQAELSARVME 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD LAPAGMPTQQQVPFLSVGGDIGVRTVQHQDCSPLSGDYVIEDVQGDDKRYFRRLIFLSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 LAPAGMPTQQQVPFLSVGGDIGVRTVQHQDCSPLSGDYVIEDVQGDDKRYFRRLIFLSNR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD NVVQSEARLLKDVSHKAQKKRKKDRKKQRPADAEDLPAAPGQSIDKSYLCCEHHKAMIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 NVVQSEARLLKDVSHKAQKKRKKDRKKQRPADAEDLPAAPGQSIDKSYLCCEHHKAMIAG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD LALLRNPELLLEIPLALLVVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQWFGFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 LALLRNPELLLEIPLALLVVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQWFGFS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD QSDRMKVHIADGLDYIASLAGGGEARPCYDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 QSDRMKVHIADGLDYIASLAGGGEARPCYDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD VKSILTPEGVFILNLVCRDLGLKDSVLAGLKAVFPLLYVRRIEGEVNEILFCQLHPEQKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS12 VKSILTPEGVFILNLVCRDLGLKDSVLAGLKAVFPLLYVRRIEGEVNEILFCQLHPEQKL 610 620 630 640 650 660 670 680 690 pF1KSD ATPELLETAQALERTLRKPGRGWDDTYVLSDMLKTVKIV ::::::::::::::::::::::::::::::::::::::: CCDS12 ATPELLETAQALERTLRKPGRGWDDTYVLSDMLKTVKIV 670 680 690 >>CCDS1300.1 METTL13 gene_id:51603|Hs108|chr1 (613 aa) initn: 4094 init1: 4094 opt: 4094 Z-score: 4928.9 bits: 922.3 E(32554): 0 Smith-Waterman score: 4094; 100.0% identity (100.0% similar) in 613 aa overlap (87-699:1-613) 60 70 80 90 100 110 pF1KSD CGNSELSEQLYDVGYRDIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQMEFPDASFQ :::::::::::::::::::::::::::::: CCDS13 MKECNATRRPQMSFLKMDMTQMEFPDASFQ 10 20 30 120 130 140 150 160 170 pF1KSD VVLDKGTLDAVLTDEEEKTLQQVDRMLAEVGRVLQVGGRYLCISLAQAHILKKAVGHFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 VVLDKGTLDAVLTDEEEKTLQQVDRMLAEVGRVLQVGGRYLCISLAQAHILKKAVGHFSR 40 50 60 70 80 90 180 190 200 210 220 230 pF1KSD EGWMVRVHQVANSQDQVLEAEPQFSLPVFAFIMTKFRPVPGSALQIFELCAQEQRKPVRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 EGWMVRVHQVANSQDQVLEAEPQFSLPVFAFIMTKFRPVPGSALQIFELCAQEQRKPVRL 100 110 120 130 140 150 240 250 260 270 280 290 pF1KSD ESAERLAEAVQERQQYAWLCSQLRRKARLGSVSLDLCDGDTGEPRYTLHVVDSPTVKPSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 ESAERLAEAVQERQQYAWLCSQLRRKARLGSVSLDLCDGDTGEPRYTLHVVDSPTVKPSR 160 170 180 190 200 210 300 310 320 330 340 350 pF1KSD DNHFAIFIIPQGRETEWLFGMDEGRKQLAASAGFRRLITVALHRGQQYESMDHIQAELSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 DNHFAIFIIPQGRETEWLFGMDEGRKQLAASAGFRRLITVALHRGQQYESMDHIQAELSA 220 230 240 250 260 270 360 370 380 390 400 410 pF1KSD RVMELAPAGMPTQQQVPFLSVGGDIGVRTVQHQDCSPLSGDYVIEDVQGDDKRYFRRLIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 RVMELAPAGMPTQQQVPFLSVGGDIGVRTVQHQDCSPLSGDYVIEDVQGDDKRYFRRLIF 280 290 300 310 320 330 420 430 440 450 460 470 pF1KSD LSNRNVVQSEARLLKDVSHKAQKKRKKDRKKQRPADAEDLPAAPGQSIDKSYLCCEHHKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 LSNRNVVQSEARLLKDVSHKAQKKRKKDRKKQRPADAEDLPAAPGQSIDKSYLCCEHHKA 340 350 360 370 380 390 480 490 500 510 520 530 pF1KSD MIAGLALLRNPELLLEIPLALLVVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MIAGLALLRNPELLLEIPLALLVVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQW 400 410 420 430 440 450 540 550 560 570 580 590 pF1KSD FGFSQSDRMKVHIADGLDYIASLAGGGEARPCYDVIMFDVDSKDPTLGMSCPPPAFVEQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 FGFSQSDRMKVHIADGLDYIASLAGGGEARPCYDVIMFDVDSKDPTLGMSCPPPAFVEQS 460 470 480 490 500 510 600 610 620 630 640 650 pF1KSD FLQKVKSILTPEGVFILNLVCRDLGLKDSVLAGLKAVFPLLYVRRIEGEVNEILFCQLHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 FLQKVKSILTPEGVFILNLVCRDLGLKDSVLAGLKAVFPLLYVRRIEGEVNEILFCQLHP 520 530 540 550 560 570 660 670 680 690 pF1KSD EQKLATPELLETAQALERTLRKPGRGWDDTYVLSDMLKTVKIV ::::::::::::::::::::::::::::::::::::::::::: CCDS13 EQKLATPELLETAQALERTLRKPGRGWDDTYVLSDMLKTVKIV 580 590 600 610 >>CCDS30936.1 METTL13 gene_id:51603|Hs108|chr1 (543 aa) initn: 2628 init1: 2628 opt: 2630 Z-score: 3165.3 bits: 595.8 E(32554): 5.5e-170 Smith-Waterman score: 3303; 77.7% identity (77.7% similar) in 699 aa overlap (1-699:1-543) 10 20 30 40 50 60 pF1KSD MNLLPKSSREFGSVDYWEKFFQQRGKKAFEWYGTYLELCGVLHKYIKPREKVLVIGCGNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 MNLLPKSSREFGSVDYWEKFFQQRGKKAFEWYGTYLELCGVLHKYIKPREKVLVIGCGNS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD ELSEQLYDVGYRDIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQMEFPDASFQVVLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 ELSEQLYDVGYRDIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQMEFPDASFQVVLD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD KGTLDAVLTDEEEKTLQQVDRMLAEVGRVLQVGGRYLCISLAQAHILKKAVGHFSREGWM ::::::::::::::::::::::::::::::: CCDS30 KGTLDAVLTDEEEKTLQQVDRMLAEVGRVLQ----------------------------- 130 140 150 190 200 210 220 230 240 pF1KSD VRVHQVANSQDQVLEAEPQFSLPVFAFIMTKFRPVPGSALQIFELCAQEQRKPVRLESAE CCDS30 ------------------------------------------------------------ 250 260 270 280 290 300 pF1KSD RLAEAVQERQQYAWLCSQLRRKARLGSVSLDLCDGDTGEPRYTLHVVDSPTVKPSRDNHF CCDS30 ------------------------------------------------------------ 310 320 330 340 350 360 pF1KSD AIFIIPQGRETEWLFGMDEGRKQLAASAGFRRLITVALHRGQQYESMDHIQAELSARVME ::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 -------GRETEWLFGMDEGRKQLAASAGFRRLITVALHRGQQYESMDHIQAELSARVME 160 170 180 190 200 370 380 390 400 410 420 pF1KSD LAPAGMPTQQQVPFLSVGGDIGVRTVQHQDCSPLSGDYVIEDVQGDDKRYFRRLIFLSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 LAPAGMPTQQQVPFLSVGGDIGVRTVQHQDCSPLSGDYVIEDVQGDDKRYFRRLIFLSNR 210 220 230 240 250 260 430 440 450 460 470 480 pF1KSD NVVQSEARLLKDVSHKAQKKRKKDRKKQRPADAEDLPAAPGQSIDKSYLCCEHHKAMIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 NVVQSEARLLKDVSHKAQKKRKKDRKKQRPADAEDLPAAPGQSIDKSYLCCEHHKAMIAG 270 280 290 300 310 320 490 500 510 520 530 540 pF1KSD LALLRNPELLLEIPLALLVVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQWFGFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 LALLRNPELLLEIPLALLVVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQWFGFS 330 340 350 360 370 380 550 560 570 580 590 600 pF1KSD QSDRMKVHIADGLDYIASLAGGGEARPCYDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 QSDRMKVHIADGLDYIASLAGGGEARPCYDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQK 390 400 410 420 430 440 610 620 630 640 650 660 pF1KSD VKSILTPEGVFILNLVCRDLGLKDSVLAGLKAVFPLLYVRRIEGEVNEILFCQLHPEQKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 VKSILTPEGVFILNLVCRDLGLKDSVLAGLKAVFPLLYVRRIEGEVNEILFCQLHPEQKL 450 460 470 480 490 500 670 680 690 pF1KSD ATPELLETAQALERTLRKPGRGWDDTYVLSDMLKTVKIV ::::::::::::::::::::::::::::::::::::::: CCDS30 ATPELLETAQALERTLRKPGRGWDDTYVLSDMLKTVKIV 510 520 530 540 >>CCDS3255.1 ECE2 gene_id:9718|Hs108|chr3 (255 aa) initn: 350 init1: 141 opt: 413 Z-score: 498.5 bits: 101.3 E(32554): 1.9e-21 Smith-Waterman score: 413; 34.6% identity (69.7% similar) in 188 aa overlap (4-182:13-196) 10 20 30 40 50 pF1KSD MNLLPKSSREFGSVDYWEKFFQQRGKKA-FEWYGTYLELCGVLHKYIKPRE ::. . . :.::.. .: . .: ..:.: . . ..:. ..:.. CCDS32 MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPED 10 20 30 40 50 60 60 70 80 90 100 110 pF1KSD KVLVIGCGNSELSEQLYDVGYRDIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQMEF ..::.::::: :: .:. :. .....: : ::. :. .: . ::. . ::. ...: CCDS32 RILVLGCGNSALSYELFLGGFPNVTSVDYSSVVVAAMQARHA-HVPQLRWETMDVRKLDF 70 80 90 100 110 120 130 140 150 160 pF1KSD PDASFQVVLDKGTLDAVLTDEEE------KTLQQVDRMLAEVGRVLQVGGRYLCISLAQA :.:::.:::.::::::.:. :.. . .. ::..:.::.::: :::.. .. : CCDS32 PSASFDVVLEKGTLDALLAGERDPWTVSSEGVHTVDQVLSEVSRVLVPGGRFISMTSAAP 120 130 140 150 160 170 170 180 190 200 210 220 pF1KSD HILKKAVGHFSRE--GWMVRVHQVANSQDQVLEAEPQFSLPVFAFIMTKFRPVPGSALQI :. . :... :: .: CCDS32 HFRTR---HYAQAYYGWSLRHATYGSGFHFHLYLMHKGGKLSVAQLALGAQILSPPRPPT 180 190 200 210 220 230 >>CCDS3256.2 ECE2 gene_id:9718|Hs108|chr3 (883 aa) initn: 279 init1: 141 opt: 367 Z-score: 434.3 bits: 91.2 E(32554): 7.2e-18 Smith-Waterman score: 367; 35.1% identity (70.2% similar) in 171 aa overlap (4-167:13-180) 10 20 30 40 50 pF1KSD MNLLPKSSREFGSVDYWEKFFQQRGKKA-FEWYGTYLELCGVLHKYIKPRE ::. . . :.::.. .: . .: ..:.: . . ..:. ..:.. CCDS32 MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPED 10 20 30 40 50 60 60 70 80 90 100 110 pF1KSD KVLVIGCGNSELSEQLYDVGYRDIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQMEF ..::.::::: :: .:. :. .....: : ::. :. .: . ::. . ::. ...: CCDS32 RILVLGCGNSALSYELFLGGFPNVTSVDYSSVVVAAMQARHA-HVPQLRWETMDVRKLDF 70 80 90 100 110 120 130 140 150 160 pF1KSD PDASFQVVLDKGTLDAVLTDEEE------KTLQQVDRMLAEVGRVLQVGGRYLCISLAQA :.:::.:::.::::::.:. :.. . .. ::..:.::: .: : : : : .: CCDS32 PSASFDVVLEKGTLDALLAGERDPWTVSSEGVHTVDQVLSEVG--FQKGTRQLLGSRTQL 120 130 140 150 160 170 170 180 190 200 210 220 pF1KSD HILKKAVGHFSREGWMVRVHQVANSQDQVLEAEPQFSLPVFAFIMTKFRPVPGSALQIFE ... CCDS32 ELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCED 180 190 200 210 220 230 699 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 18:48:21 2016 done: Thu Nov 3 18:48:22 2016 Total Scan time: 3.680 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]