FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0871, 469 aa 1>>>pF1KSDA0871 469 - 469 aa - 469 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.3878+/-0.000596; mu= -0.4359+/- 0.037 mean_var=338.0438+/-70.453, 0's: 0 Z-trim(115.1): 53 B-trim: 336 in 1/57 Lambda= 0.069757 statistics sampled from 25226 (25274) to 25226 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.296), width: 16 Scan time: 8.270 The best scores are: opt bits E(85289) NP_055776 (OMIM: 611194) protein RUFY3 isoform 2 [ ( 469) 2996 316.1 1.3e-85 NP_001032519 (OMIM: 611194) protein RUFY3 isoform ( 620) 2846 301.1 5.6e-81 NP_001332769 (OMIM: 611194) protein RUFY3 isoform ( 416) 2593 275.5 2e-73 NP_001278923 (OMIM: 611194) protein RUFY3 isoform ( 487) 2593 275.5 2.2e-73 XP_011530057 (OMIM: 611194) PREDICTED: protein RUF ( 529) 2579 274.2 6.2e-73 XP_016863381 (OMIM: 611194) PREDICTED: protein RUF ( 405) 2549 271.0 4.2e-72 NP_001278922 (OMIM: 611194) protein RUFY3 isoform ( 567) 2443 260.5 8.5e-69 XP_005265713 (OMIM: 611194) PREDICTED: protein RUF ( 638) 2443 260.6 9.2e-69 XP_011530058 (OMIM: 611194) PREDICTED: protein RUF ( 518) 2434 259.6 1.5e-68 NP_001124181 (OMIM: 611194) protein RUFY3 isoform ( 506) 2429 259.1 2.1e-68 XP_011530056 (OMIM: 611194) PREDICTED: protein RUF ( 586) 2429 259.1 2.3e-68 XP_016863379 (OMIM: 611194) PREDICTED: protein RUF ( 587) 2429 259.1 2.3e-68 XP_011530054 (OMIM: 611194) PREDICTED: protein RUF ( 621) 2429 259.2 2.4e-68 XP_011530055 (OMIM: 611194) PREDICTED: protein RUF ( 621) 2429 259.2 2.4e-68 XP_011530053 (OMIM: 611194) PREDICTED: protein RUF ( 657) 2429 259.2 2.5e-68 XP_011530052 (OMIM: 611194) PREDICTED: protein RUF ( 680) 2429 259.2 2.6e-68 XP_005265715 (OMIM: 611194) PREDICTED: protein RUF ( 556) 2399 256.1 1.8e-67 XP_005270013 (OMIM: 610328) PREDICTED: RUN and FYV ( 585) 1321 147.6 8.5e-35 XP_016865380 (OMIM: 610327) PREDICTED: RUN and FYV ( 578) 1298 145.3 4.2e-34 XP_006714984 (OMIM: 610327) PREDICTED: RUN and FYV ( 686) 1298 145.4 4.7e-34 NP_001317032 (OMIM: 610328) RUN and FYVE domain-co ( 606) 1286 144.1 1e-33 XP_011538244 (OMIM: 610328) PREDICTED: RUN and FYV ( 606) 1286 144.1 1e-33 NP_060457 (OMIM: 610328) RUN and FYVE domain-conta ( 641) 1286 144.1 1e-33 NP_001035541 (OMIM: 610327) RUN and FYVE domain-co ( 600) 1276 143.1 2e-33 NP_001035542 (OMIM: 610327) RUN and FYVE domain-co ( 600) 1276 143.1 2e-33 NP_079434 (OMIM: 610327) RUN and FYVE domain-conta ( 708) 1276 143.2 2.2e-33 XP_005270012 (OMIM: 610328) PREDICTED: RUN and FYV ( 590) 1247 140.2 1.5e-32 NP_001265154 (OMIM: 610328) RUN and FYVE domain-co ( 379) 994 114.5 5.2e-25 NP_001035882 (OMIM: 610328) RUN and FYVE domain-co ( 403) 656 80.5 9.4e-15 XP_005270014 (OMIM: 610328) PREDICTED: RUN and FYV ( 572) 645 79.6 2.5e-14 XP_005270010 (OMIM: 610328) PREDICTED: RUN and FYV ( 607) 645 79.6 2.6e-14 XP_005266050 (OMIM: 610327) PREDICTED: RUN and FYV ( 465) 604 75.3 3.9e-13 XP_016865382 (OMIM: 610327) PREDICTED: RUN and FYV ( 416) 438 58.6 3.8e-08 XP_016865381 (OMIM: 610327) PREDICTED: RUN and FYV ( 438) 378 52.6 2.6e-06 NP_001138298 (OMIM: 605448) RUN domain-containing ( 400) 376 52.3 2.8e-06 XP_005257021 (OMIM: 605448) PREDICTED: RUN domain- ( 441) 376 52.4 3e-06 XP_016879526 (OMIM: 605448) PREDICTED: RUN domain- ( 469) 376 52.4 3.1e-06 XP_016879529 (OMIM: 605448) PREDICTED: RUN domain- ( 401) 370 51.7 4.3e-06 XP_016879525 (OMIM: 605448) PREDICTED: RUN domain- ( 470) 370 51.8 4.8e-06 XP_016865383 (OMIM: 610327) PREDICTED: RUN and FYV ( 368) 364 51.1 6.2e-06 XP_006714985 (OMIM: 610327) PREDICTED: RUN and FYV ( 368) 364 51.1 6.2e-06 NP_006686 (OMIM: 605448) RUN domain-containing pro ( 405) 361 50.8 8.1e-06 XP_016879528 (OMIM: 605448) PREDICTED: RUN domain- ( 433) 361 50.9 8.5e-06 XP_016879527 (OMIM: 605448) PREDICTED: RUN domain- ( 434) 361 50.9 8.5e-06 NP_001138297 (OMIM: 605448) RUN domain-containing ( 446) 361 50.9 8.7e-06 XP_016879524 (OMIM: 605448) PREDICTED: RUN domain- ( 474) 361 50.9 9e-06 XP_016865384 (OMIM: 610327) PREDICTED: RUN and FYV ( 310) 339 48.5 3.2e-05 >>NP_055776 (OMIM: 611194) protein RUFY3 isoform 2 [Homo (469 aa) initn: 2996 init1: 2996 opt: 2996 Z-score: 1657.8 bits: 316.1 E(85289): 1.3e-85 Smith-Waterman score: 2996; 100.0% identity (100.0% similar) in 469 aa overlap (1-469:1-469) 10 20 30 40 50 60 pF1KSD MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 370 380 390 400 410 420 430 440 450 460 pF1KSD QKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPKHH ::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPKHH 430 440 450 460 >>NP_001032519 (OMIM: 611194) protein RUFY3 isoform 1 [H (620 aa) initn: 2846 init1: 2846 opt: 2846 Z-score: 1574.8 bits: 301.1 E(85289): 5.6e-81 Smith-Waterman score: 2846; 100.0% identity (100.0% similar) in 445 aa overlap (1-445:1-445) 10 20 30 40 50 60 pF1KSD MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 370 380 390 400 410 420 430 440 450 460 pF1KSD QKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPKHH ::::::::::::::::::::::::: NP_001 QKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVE 430 440 450 460 470 480 >>NP_001332769 (OMIM: 611194) protein RUFY3 isoform 6 [H (416 aa) initn: 2593 init1: 2593 opt: 2593 Z-score: 1439.2 bits: 275.5 E(85289): 2e-73 Smith-Waterman score: 2593; 100.0% identity (100.0% similar) in 411 aa overlap (59-469:6-416) 30 40 50 60 70 80 pF1KSD CKFRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESAL :::::::::::::::::::::::::::::: NP_001 MRDDTEDPNYLMANERMNLMNMAKLSIKGLIESAL 10 20 30 90 100 110 120 130 140 pF1KSD NLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITA 40 50 60 70 80 90 150 160 170 180 190 200 pF1KSD SVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAII 100 110 120 130 140 150 210 220 230 240 250 260 pF1KSD AGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVE 160 170 180 190 200 210 270 280 290 300 310 320 pF1KSD ELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNR 220 230 240 250 260 270 330 340 350 360 370 380 pF1KSD KGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ 280 290 300 310 320 330 390 400 410 420 430 440 pF1KSD DALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEK 340 350 360 370 380 390 450 460 pF1KSD DLVKQAKTLNSAANKLIPKHH ::::::::::::::::::::: NP_001 DLVKQAKTLNSAANKLIPKHH 400 410 >>NP_001278923 (OMIM: 611194) protein RUFY3 isoform 5 [H (487 aa) initn: 2593 init1: 2593 opt: 2593 Z-score: 1438.4 bits: 275.5 E(85289): 2.2e-73 Smith-Waterman score: 2950; 96.3% identity (96.3% similar) in 487 aa overlap (1-469:1-487) 10 20 30 40 50 60 pF1KSD MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED 10 20 30 40 50 60 70 80 90 100 pF1KSD ------------------PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQ :::::::::::::::::::::::::::::::::::::::::: NP_001 SWEDLTDLVEQMRDDTEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQ 70 80 90 100 110 120 110 120 130 140 150 160 pF1KSD QFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGR 130 140 150 160 170 180 170 180 190 200 210 220 pF1KSD GRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANF 190 200 210 220 230 240 230 240 250 260 270 280 pF1KSD CMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQ 250 260 270 280 290 300 290 300 310 320 330 340 pF1KSD AKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQAL 310 320 330 340 350 360 350 360 370 380 390 400 pF1KSD SEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLR 370 380 390 400 410 420 410 420 430 440 450 460 pF1KSD ALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAAN 430 440 450 460 470 480 pF1KSD KLIPKHH ::::::: NP_001 KLIPKHH >>XP_011530057 (OMIM: 611194) PREDICTED: protein RUFY3 i (529 aa) initn: 2579 init1: 2579 opt: 2579 Z-score: 1430.4 bits: 274.2 E(85289): 6.2e-73 Smith-Waterman score: 2579; 100.0% identity (100.0% similar) in 409 aa overlap (61-469:121-529) 40 50 60 70 80 90 pF1KSD FRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNL :::::::::::::::::::::::::::::: XP_011 TPPSPGSPLPFLLLSYPSGGGGSSGSGKHHPNYLMANERMNLMNMAKLSIKGLIESALNL 100 110 120 130 140 150 100 110 120 130 140 150 pF1KSD GRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASV 160 170 180 190 200 210 160 170 180 190 200 210 pF1KSD KDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAG 220 230 240 250 260 270 220 230 240 250 260 270 pF1KSD LLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEEL 280 290 300 310 320 330 280 290 300 310 320 330 pF1KSD NRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKG 340 350 360 370 380 390 340 350 360 370 380 390 pF1KSD PKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDA 400 410 420 430 440 450 400 410 420 430 440 450 pF1KSD LVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDL 460 470 480 490 500 510 460 pF1KSD VKQAKTLNSAANKLIPKHH ::::::::::::::::::: XP_011 VKQAKTLNSAANKLIPKHH 520 >>XP_016863381 (OMIM: 611194) PREDICTED: protein RUFY3 i (405 aa) initn: 2549 init1: 2549 opt: 2549 Z-score: 1415.4 bits: 271.0 E(85289): 4.2e-72 Smith-Waterman score: 2549; 100.0% identity (100.0% similar) in 405 aa overlap (65-469:1-405) 40 50 60 70 80 90 pF1KSD MDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTL :::::::::::::::::::::::::::::: XP_016 MANERMNLMNMAKLSIKGLIESALNLGRTL 10 20 30 100 110 120 130 140 150 pF1KSD DSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLP 40 50 60 70 80 90 160 170 180 190 200 210 pF1KSD GLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVG 100 110 120 130 140 150 220 230 240 250 260 270 pF1KSD LNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHL 160 170 180 190 200 210 280 290 300 310 320 330 pF1KSD NATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQD 220 230 240 250 260 270 340 350 360 370 380 390 pF1KSD RTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSL 280 290 300 310 320 330 400 410 420 430 440 450 pF1KSD RQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQA 340 350 360 370 380 390 460 pF1KSD KTLNSAANKLIPKHH ::::::::::::::: XP_016 KTLNSAANKLIPKHH 400 >>NP_001278922 (OMIM: 611194) protein RUFY3 isoform 4 [H (567 aa) initn: 2443 init1: 2443 opt: 2443 Z-score: 1356.1 bits: 260.5 E(85289): 8.5e-69 Smith-Waterman score: 2443; 100.0% identity (100.0% similar) in 387 aa overlap (59-445:6-392) 30 40 50 60 70 80 pF1KSD CKFRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESAL :::::::::::::::::::::::::::::: NP_001 MRDDTEDPNYLMANERMNLMNMAKLSIKGLIESAL 10 20 30 90 100 110 120 130 140 pF1KSD NLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITA 40 50 60 70 80 90 150 160 170 180 190 200 pF1KSD SVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAII 100 110 120 130 140 150 210 220 230 240 250 260 pF1KSD AGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVE 160 170 180 190 200 210 270 280 290 300 310 320 pF1KSD ELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNR 220 230 240 250 260 270 330 340 350 360 370 380 pF1KSD KGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ 280 290 300 310 320 330 390 400 410 420 430 440 pF1KSD DALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLR 340 350 360 370 380 390 450 460 pF1KSD DLVKQAKTLNSAANKLIPKHH NP_001 QAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIP 400 410 420 430 440 450 >>XP_005265713 (OMIM: 611194) PREDICTED: protein RUFY3 i (638 aa) initn: 2443 init1: 2443 opt: 2443 Z-score: 1355.5 bits: 260.6 E(85289): 9.2e-69 Smith-Waterman score: 2800; 96.1% identity (96.1% similar) in 463 aa overlap (1-445:1-463) 10 20 30 40 50 60 pF1KSD MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED 10 20 30 40 50 60 70 80 90 100 pF1KSD ------------------PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQ :::::::::::::::::::::::::::::::::::::::::: XP_005 SWEDLTDLVEQMRDDTEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQ 70 80 90 100 110 120 110 120 130 140 150 160 pF1KSD QFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGR 130 140 150 160 170 180 170 180 190 200 210 220 pF1KSD GRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANF 190 200 210 220 230 240 230 240 250 260 270 280 pF1KSD CMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQ 250 260 270 280 290 300 290 300 310 320 330 340 pF1KSD AKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQAL 310 320 330 340 350 360 350 360 370 380 390 400 pF1KSD SEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLR 370 380 390 400 410 420 410 420 430 440 450 460 pF1KSD ALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAAN ::::::::::::::::::::::::::::::::::::::::::: XP_005 ALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNR 430 440 450 460 470 480 pF1KSD KLIPKHH XP_005 LFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPGRGSQKSESKMDGK 490 500 510 520 530 540 >>XP_011530058 (OMIM: 611194) PREDICTED: protein RUFY3 i (518 aa) initn: 2434 init1: 2434 opt: 2434 Z-score: 1351.6 bits: 259.6 E(85289): 1.5e-68 Smith-Waterman score: 2434; 97.5% identity (98.0% similar) in 398 aa overlap (61-458:121-518) 40 50 60 70 80 90 pF1KSD FRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNL :::::::::::::::::::::::::::::: XP_011 TPPSPGSPLPFLLLSYPSGGGGSSGSGKHHPNYLMANERMNLMNMAKLSIKGLIESALNL 100 110 120 130 140 150 100 110 120 130 140 150 pF1KSD GRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASV 160 170 180 190 200 210 160 170 180 190 200 210 pF1KSD KDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAG 220 230 240 250 260 270 220 230 240 250 260 270 pF1KSD LLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEEL 280 290 300 310 320 330 280 290 300 310 320 330 pF1KSD NRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKG 340 350 360 370 380 390 340 350 360 370 380 390 pF1KSD PKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDA 400 410 420 430 440 450 400 410 420 430 440 450 pF1KSD LVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: . XP_011 LVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRMGST 460 470 480 490 500 510 460 pF1KSD VKQAKTLNSAANKLIPKHH . : :: XP_011 KCKRKMLN >>NP_001124181 (OMIM: 611194) protein RUFY3 isoform 3 [H (506 aa) initn: 2429 init1: 2429 opt: 2429 Z-score: 1349.0 bits: 259.1 E(85289): 2.1e-68 Smith-Waterman score: 2429; 100.0% identity (100.0% similar) in 385 aa overlap (61-445:121-505) 40 50 60 70 80 90 pF1KSD FRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNL :::::::::::::::::::::::::::::: NP_001 TPPSPGSPLPFLLLSYPSGGGGSSGSGKHHPNYLMANERMNLMNMAKLSIKGLIESALNL 100 110 120 130 140 150 100 110 120 130 140 150 pF1KSD GRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASV 160 170 180 190 200 210 160 170 180 190 200 210 pF1KSD KDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAG 220 230 240 250 260 270 220 230 240 250 260 270 pF1KSD LLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEEL 280 290 300 310 320 330 280 290 300 310 320 330 pF1KSD NRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKG 340 350 360 370 380 390 340 350 360 370 380 390 pF1KSD PKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDA 400 410 420 430 440 450 400 410 420 430 440 450 pF1KSD LVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 460 470 480 490 500 460 pF1KSD VKQAKTLNSAANKLIPKHH 469 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 03:51:38 2016 done: Thu Nov 3 03:51:39 2016 Total Scan time: 8.270 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]