FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0876, 1096 aa 1>>>pF1KSDA0876 1096 - 1096 aa - 1096 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.6136+/-0.000472; mu= -7.3250+/- 0.029 mean_var=346.2338+/-72.435, 0's: 0 Z-trim(120.2): 131 B-trim: 1387 in 2/54 Lambda= 0.068927 statistics sampled from 35016 (35150) to 35016 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.725), E-opt: 0.2 (0.412), width: 16 Scan time: 17.850 The best scores are: opt bits E(85289) NP_055830 (OMIM: 609765) lysine-specific demethyla (1096) 7580 768.7 0 XP_011526119 (OMIM: 609765) PREDICTED: lysine-spec ( 770) 5008 512.8 3e-144 XP_011526116 (OMIM: 609765) PREDICTED: lysine-spec (1038) 5008 512.9 3.8e-144 XP_016881992 (OMIM: 609765) PREDICTED: lysine-spec (1130) 5008 513.0 4e-144 XP_005259578 (OMIM: 609765) PREDICTED: lysine-spec (1130) 5008 513.0 4e-144 XP_011526118 (OMIM: 609765) PREDICTED: lysine-spec ( 787) 4554 467.7 1.2e-130 XP_016881993 (OMIM: 609765) PREDICTED: lysine-spec ( 473) 2594 272.7 3.7e-72 XP_006716804 (OMIM: 605469) PREDICTED: lysine-spec (1089) 2587 272.2 1.2e-71 XP_011526120 (OMIM: 609765) PREDICTED: lysine-spec ( 429) 2572 270.4 1.6e-71 XP_016869993 (OMIM: 605469) PREDICTED: lysine-spec ( 763) 2145 228.1 1.5e-58 XP_016869992 (OMIM: 605469) PREDICTED: lysine-spec ( 793) 2145 228.2 1.5e-58 XP_011526124 (OMIM: 609765) PREDICTED: lysine-spec ( 312) 2134 226.8 1.6e-58 XP_016869991 (OMIM: 605469) PREDICTED: lysine-spec ( 811) 2145 228.2 1.6e-58 NP_001140167 (OMIM: 605469) lysine-specific demeth ( 813) 2145 228.2 1.6e-58 NP_001140168 (OMIM: 605469) lysine-specific demeth ( 835) 2145 228.2 1.6e-58 XP_011526122 (OMIM: 609765) PREDICTED: lysine-spec ( 330) 2134 226.8 1.6e-58 XP_011526121 (OMIM: 609765) PREDICTED: lysine-spec ( 330) 2134 226.8 1.6e-58 XP_011526123 (OMIM: 609765) PREDICTED: lysine-spec ( 330) 2134 226.8 1.6e-58 XP_016881994 (OMIM: 609765) PREDICTED: lysine-spec ( 330) 2134 226.8 1.6e-58 XP_016869987 (OMIM: 605469) PREDICTED: lysine-spec ( 999) 2145 228.2 1.9e-58 NP_001291268 (OMIM: 605469) lysine-specific demeth (1023) 2145 228.2 1.9e-58 NP_055876 (OMIM: 605469) lysine-specific demethyla (1056) 2145 228.2 1.9e-58 XP_005271411 (OMIM: 609764) PREDICTED: lysine-spec (1064) 2010 214.8 2.1e-54 NP_055478 (OMIM: 609764) lysine-specific demethyla (1064) 2010 214.8 2.1e-54 XP_005271412 (OMIM: 609764) PREDICTED: lysine-spec (1064) 2010 214.8 2.1e-54 NP_060509 (OMIM: 609766) lysine-specific demethyla ( 523) 1909 204.6 1.3e-51 NP_001155102 (OMIM: 616581) lysine-specific demeth ( 506) 1810 194.7 1.1e-48 XP_016869988 (OMIM: 605469) PREDICTED: lysine-spec ( 949) 1781 192.0 1.4e-47 XP_016869995 (OMIM: 605469) PREDICTED: lysine-spec ( 619) 1772 191.0 1.8e-47 XP_016869990 (OMIM: 605469) PREDICTED: lysine-spec ( 858) 1772 191.1 2.4e-47 XP_011540769 (OMIM: 609764) PREDICTED: lysine-spec ( 699) 1671 181.0 2.1e-44 XP_011516113 (OMIM: 605469) PREDICTED: lysine-spec ( 908) 1606 174.6 2.3e-42 XP_016869989 (OMIM: 605469) PREDICTED: lysine-spec ( 908) 1606 174.6 2.3e-42 XP_005271413 (OMIM: 609764) PREDICTED: lysine-spec ( 973) 1505 164.6 2.6e-39 XP_016858401 (OMIM: 609764) PREDICTED: lysine-spec ( 973) 1505 164.6 2.6e-39 XP_016869994 (OMIM: 605469) PREDICTED: lysine-spec ( 652) 1239 138.0 1.7e-31 XP_011516118 (OMIM: 605469) PREDICTED: lysine-spec ( 776) 1239 138.1 2e-31 XP_011516114 (OMIM: 605469) PREDICTED: lysine-spec ( 886) 1239 138.1 2.2e-31 NP_001291269 (OMIM: 605469) lysine-specific demeth ( 801) 1164 130.6 3.6e-29 NP_001291270 (OMIM: 605469) lysine-specific demeth ( 151) 807 94.6 4.6e-19 NP_001305978 (OMIM: 602410) peregrin isoform 3 [Ho (1119) 452 59.9 9.7e-08 XP_005265509 (OMIM: 602410) PREDICTED: peregrin is (1125) 452 59.9 9.7e-08 NP_001305979 (OMIM: 602410) peregrin isoform 4 [Ho (1213) 452 59.9 1e-07 NP_004625 (OMIM: 602410) peregrin isoform 2 [Homo (1214) 452 59.9 1e-07 XP_005265507 (OMIM: 602410) PREDICTED: peregrin is (1219) 452 59.9 1e-07 NP_001003694 (OMIM: 602410) peregrin isoform 1 [Ho (1220) 452 59.9 1e-07 XP_005265506 (OMIM: 602410) PREDICTED: peregrin is (1247) 452 59.9 1.1e-07 XP_011532403 (OMIM: 602410) PREDICTED: peregrin is (1248) 452 59.9 1.1e-07 XP_011532404 (OMIM: 602410) PREDICTED: peregrin is (1248) 452 59.9 1.1e-07 NP_001140177 (OMIM: 415000,426000) lysine-specific (1570) 453 60.1 1.2e-07 >>NP_055830 (OMIM: 609765) lysine-specific demethylase 4 (1096 aa) initn: 7580 init1: 7580 opt: 7580 Z-score: 4090.8 bits: 768.7 E(85289): 0 Smith-Waterman score: 7580; 100.0% identity (100.0% similar) in 1096 aa overlap (1-1096:1-1096) 10 20 30 40 50 60 pF1KSD MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD KYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD HKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 HKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD EEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALW 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD LPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD NQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD SKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQW 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD KNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGEGCPATLPSKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGEGCPATLPSKS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD RQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVN 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD EGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDI 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD SAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD ITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDN 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD LYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKR 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD GDIFTLEEELPKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GDIFTLEEELPKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVA 1030 1040 1050 1060 1070 1080 1090 pF1KSD FVESLLQVQGRPGAPF :::::::::::::::: NP_055 FVESLLQVQGRPGAPF 1090 >>XP_011526119 (OMIM: 609765) PREDICTED: lysine-specific (770 aa) initn: 5008 init1: 5008 opt: 5008 Z-score: 2710.8 bits: 512.8 E(85289): 3e-144 Smith-Waterman score: 5008; 100.0% identity (100.0% similar) in 724 aa overlap (373-1096:47-770) 350 360 370 380 390 400 pF1KSD DHTRPTALTSPELSSWSASRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLE :::::::::::::::::::::::::::::: XP_011 KENRHWRKTEEERKPSLERKKEQTKRPGLSSHRKRSQPKKPKPEDPKFPGEGTAGAALLE 20 30 40 50 60 70 410 420 430 440 450 460 pF1KSD EAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLL 80 90 100 110 120 130 470 480 490 500 510 520 pF1KSD PPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKP 140 150 160 170 180 190 530 540 550 560 570 580 pF1KSD RPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGA 200 210 220 230 240 250 590 600 610 620 630 640 pF1KSD GRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSG 260 270 280 290 300 310 650 660 670 680 690 700 pF1KSD EEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKE 320 330 340 350 360 370 710 720 730 740 750 760 pF1KSD APIASLGEGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APIASLGEGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGK 380 390 400 410 420 430 770 780 790 800 810 820 pF1KSD CCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAI 440 450 460 470 480 490 830 840 850 860 870 880 pF1KSD AVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTC 500 510 520 530 540 550 890 900 910 920 930 940 pF1KSD AHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGA 560 570 580 590 600 610 950 960 970 980 990 1000 pF1KSD ASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVT 620 630 640 650 660 670 1010 1020 1030 1040 1050 1060 pF1KSD SHIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPR 680 690 700 710 720 730 1070 1080 1090 pF1KSD VGTPLATEDSGRSQDYVAFVESLLQVQGRPGAPF :::::::::::::::::::::::::::::::::: XP_011 VGTPLATEDSGRSQDYVAFVESLLQVQGRPGAPF 740 750 760 770 >>XP_011526116 (OMIM: 609765) PREDICTED: lysine-specific (1038 aa) initn: 5008 init1: 5008 opt: 5008 Z-score: 2708.9 bits: 512.9 E(85289): 3.8e-144 Smith-Waterman score: 6872; 96.7% identity (96.7% similar) in 1038 aa overlap (93-1096:1-1038) 70 80 90 100 110 120 pF1KSD IDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKY :::::::::::::::::::::::::::::: XP_011 MTVGEYRRLANSEKYCTPRHQDFDDLERKY 10 20 30 130 140 150 160 170 180 pF1KSD WKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFGMW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFGMW 40 50 60 70 80 90 190 200 210 220 230 240 pF1KSD KTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHK 100 110 120 130 140 150 250 260 270 280 290 300 pF1KSD MTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGK 160 170 180 190 200 210 310 320 330 340 350 360 pF1KSD VATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSASR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSASR 220 230 240 250 260 270 370 380 pF1KSD ASLKAKLLRR----------------------------------SHRKRSQPKKPKPEDP :::::::::: :::::::::::::::: XP_011 ASLKAKLLRRQISLKENRHWRKTEEERKPSLERKKEQTKRPGLSSHRKRSQPKKPKPEDP 280 290 300 310 320 330 390 400 410 420 430 440 pF1KSD KFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLRPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLRPT 340 350 360 370 380 390 450 460 470 480 490 500 pF1KSD KAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNV 400 410 420 430 440 450 510 520 530 540 550 560 pF1KSD VPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPM 460 470 480 490 500 510 570 580 590 600 610 620 pF1KSD ELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVK 520 530 540 550 560 570 630 640 650 660 670 680 pF1KSD QEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAICT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAICT 580 590 600 610 620 630 690 700 710 720 730 740 pF1KSD LFYPYCQALQTEKEAPIASLGEGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPANSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFYPYCQALQTEKEAPIASLGEGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPANSY 640 650 660 670 680 690 750 760 770 780 790 800 pF1KSD IGDDGTSPLIACGKCCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGDDGTSPLIACGKCCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGALQ 700 710 720 730 740 750 810 820 830 840 850 860 pF1KSD MTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGACIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGACIQ 760 770 780 790 800 810 870 880 890 900 910 920 pF1KSD CSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVITK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVITK 820 830 840 850 860 870 930 940 950 960 970 980 pF1KSD NRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELRWT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELRWT 880 890 900 910 920 930 990 1000 1010 1020 1030 1040 pF1KSD DGNLYKAKFISSVTSHIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGAPQEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGNLYKAKFISSVTSHIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGAPQEP 940 950 960 970 980 990 1050 1060 1070 1080 1090 pF1KSD AFSGEEAKAAKRPRVGTPLATEDSGRSQDYVAFVESLLQVQGRPGAPF :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AFSGEEAKAAKRPRVGTPLATEDSGRSQDYVAFVESLLQVQGRPGAPF 1000 1010 1020 1030 >>XP_016881992 (OMIM: 609765) PREDICTED: lysine-specific (1130 aa) initn: 5008 init1: 5008 opt: 5008 Z-score: 2708.4 bits: 513.0 E(85289): 4e-144 Smith-Waterman score: 7487; 97.0% identity (97.0% similar) in 1128 aa overlap (3-1096:3-1130) 10 20 30 40 50 60 pF1KSD MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD KYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD HKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA 310 320 330 340 350 360 370 380 pF1KSD SRASLKAKLLRR----------------------------------SHRKRSQPKKPKPE :::::::::::: :::::::::::::: XP_016 SRASLKAKLLRRQISLKENRHWRKTEEERKPSLERKKEQTKRPGLSSHRKRSQPKKPKPE 370 380 390 400 410 420 390 400 410 420 430 440 pF1KSD DPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLR 430 440 450 460 470 480 450 460 470 480 490 500 pF1KSD PTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPL 490 500 510 520 530 540 510 520 530 540 550 560 pF1KSD NVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVS 550 560 570 580 590 600 570 580 590 600 610 620 pF1KSD PMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSV 610 620 630 640 650 660 630 640 650 660 670 680 pF1KSD VKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAI 670 680 690 700 710 720 690 700 710 720 730 740 pF1KSD CTLFYPYCQALQTEKEAPIASLGEGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CTLFYPYCQALQTEKEAPIASLGEGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPAN 730 740 750 760 770 780 750 760 770 780 790 800 pF1KSD SYIGDDGTSPLIACGKCCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYIGDDGTSPLIACGKCCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGA 790 800 810 820 830 840 810 820 830 840 850 860 pF1KSD LQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGAC 850 860 870 880 890 900 870 880 890 900 910 920 pF1KSD IQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVI 910 920 930 940 950 960 930 940 950 960 970 980 pF1KSD TKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELR 970 980 990 1000 1010 1020 990 1000 1010 1020 1030 1040 pF1KSD WTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGAPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGAPQ 1030 1040 1050 1060 1070 1080 1050 1060 1070 1080 1090 pF1KSD EPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVAFVESLLQVQGRPGAPF :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVAFVESLLQVQGRPGAPF 1090 1100 1110 1120 1130 >>XP_005259578 (OMIM: 609765) PREDICTED: lysine-specific (1130 aa) initn: 5008 init1: 5008 opt: 5008 Z-score: 2708.4 bits: 513.0 E(85289): 4e-144 Smith-Waterman score: 7487; 97.0% identity (97.0% similar) in 1128 aa overlap (3-1096:3-1130) 10 20 30 40 50 60 pF1KSD MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD KYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD HKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA 310 320 330 340 350 360 370 380 pF1KSD SRASLKAKLLRR----------------------------------SHRKRSQPKKPKPE :::::::::::: :::::::::::::: XP_005 SRASLKAKLLRRQISLKENRHWRKTEEERKPSLERKKEQTKRPGLSSHRKRSQPKKPKPE 370 380 390 400 410 420 390 400 410 420 430 440 pF1KSD DPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLR 430 440 450 460 470 480 450 460 470 480 490 500 pF1KSD PTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPL 490 500 510 520 530 540 510 520 530 540 550 560 pF1KSD NVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVS 550 560 570 580 590 600 570 580 590 600 610 620 pF1KSD PMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSV 610 620 630 640 650 660 630 640 650 660 670 680 pF1KSD VKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAI 670 680 690 700 710 720 690 700 710 720 730 740 pF1KSD CTLFYPYCQALQTEKEAPIASLGEGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CTLFYPYCQALQTEKEAPIASLGEGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPAN 730 740 750 760 770 780 750 760 770 780 790 800 pF1KSD SYIGDDGTSPLIACGKCCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SYIGDDGTSPLIACGKCCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGA 790 800 810 820 830 840 810 820 830 840 850 860 pF1KSD LQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGAC 850 860 870 880 890 900 870 880 890 900 910 920 pF1KSD IQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVI 910 920 930 940 950 960 930 940 950 960 970 980 pF1KSD TKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELR 970 980 990 1000 1010 1020 990 1000 1010 1020 1030 1040 pF1KSD WTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGAPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGAPQ 1030 1040 1050 1060 1070 1080 1050 1060 1070 1080 1090 pF1KSD EPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVAFVESLLQVQGRPGAPF :::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVAFVESLLQVQGRPGAPF 1090 1100 1110 1120 1130 >>XP_011526118 (OMIM: 609765) PREDICTED: lysine-specific (787 aa) initn: 4554 init1: 4554 opt: 4554 Z-score: 2466.6 bits: 467.7 E(85289): 1.2e-130 Smith-Waterman score: 4558; 88.7% identity (91.6% similar) in 764 aa overlap (333-1096:43-787) 310 320 330 340 350 360 pF1KSD VATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSASR : . : : .: ... : . :. XP_011 HLWKREGHGPGVSRAGPFRGPRRTSPRPLSWAWRQHLCVPVFSRSVSVQIPPFLRTLATL 20 30 40 50 60 70 370 380 390 400 410 420 pF1KSD ASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEE . . : : .: :. :.. :: :. :: .. .: .. . : XP_011 GLARPKGLIITHSVCSDAL---PKQGGTPGPGARTAAPFNSTGTQLCSRRGASC------ 80 90 100 110 120 430 440 450 460 470 480 pF1KSD EEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLP : . :.: ::::::::::::::::::::::::::::::::::::::::::: XP_011 ---------RAGAGTE-DGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLP 130 140 150 160 170 490 500 510 520 530 540 pF1KSD SPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQ 180 190 200 210 220 230 550 560 570 580 590 600 pF1KSD EHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSK 240 250 260 270 280 290 610 620 630 640 650 660 pF1KSD LKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKN 300 310 320 330 340 350 670 680 690 700 710 720 pF1KSD RAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGEGCPATLPSKSRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGEGCPATLPSKSRQ 360 370 380 390 400 410 730 740 750 760 770 780 pF1KSD KTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVNEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVNEG 420 430 440 450 460 470 790 800 810 820 830 840 pF1KSD WTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISA 480 490 500 510 520 530 850 860 870 880 890 900 pF1KSD IPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSIT 540 550 560 570 580 590 910 920 930 940 950 960 pF1KSD CLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLY 600 610 620 630 640 650 970 980 990 1000 1010 1020 pF1KSD PESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKRGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKRGD 660 670 680 690 700 710 1030 1040 1050 1060 1070 1080 pF1KSD IFTLEEELPKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IFTLEEELPKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVAFV 720 730 740 750 760 770 1090 pF1KSD ESLLQVQGRPGAPF :::::::::::::: XP_011 ESLLQVQGRPGAPF 780 >>XP_016881993 (OMIM: 609765) PREDICTED: lysine-specific (473 aa) initn: 2624 init1: 2581 opt: 2594 Z-score: 1416.5 bits: 272.7 E(85289): 3.7e-72 Smith-Waterman score: 2949; 92.8% identity (92.8% similar) in 472 aa overlap (1-438:1-472) 10 20 30 40 50 60 pF1KSD MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD KYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD HKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA 310 320 330 340 350 360 370 380 pF1KSD SRASLKAKLLRR----------------------------------SHRKRSQPKKPKPE :::::::::::: :::::::::::::: XP_016 SRASLKAKLLRRQISLKENRHWRKTEEERKPSLERKKEQTKRPGLSSHRKRSQPKKPKPE 370 380 390 400 410 420 390 400 410 420 430 440 pF1KSD DPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLR :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEG 430 440 450 460 470 450 460 470 480 490 500 pF1KSD PTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPL >>XP_006716804 (OMIM: 605469) PREDICTED: lysine-specific (1089 aa) initn: 3848 init1: 2109 opt: 2587 Z-score: 1407.5 bits: 272.2 E(85289): 1.2e-71 Smith-Waterman score: 3804; 53.5% identity (73.6% similar) in 1091 aa overlap (10-1062:11-1055) 10 20 30 40 50 pF1KSD MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQT :::::::::::.::::..::::.::.::.:::::::::.:::::::::: XP_006 MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KSD YDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLE :::::...:::::::.:::::::::::::::::::: :.:.:::: ::::::. :..::: XP_006 YDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KSD RKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYF ::::::::::.:::::::.::.::. : .:::. : :.::.::.::: ::::::::::: XP_006 RKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KSD GMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFL ::::::::::::::::::::::::::::::::::::::::::::: ::::.::::::::: XP_006 GMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFL 190 200 210 220 230 240 240 250 260 270 280 290 pF1KSD RHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWID ::::::::: .::::::::..::::::::::::::::::::::::::::::::::.:::: XP_006 RHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWID 250 260 270 280 290 300 300 310 320 330 340 350 pF1KSD YGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWS ::::: :::::::::::::.::: .::.::.:::::::. ..:::.:: ..::...: XP_006 YGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KSD ASRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPE : ... : : . :: :.:: .. .::.. ::: XP_006 QRRRKVR-KASRSFQCARSTSKRPKADE---------------------EEEVSDEVDGA 370 380 390 420 430 440 450 460 470 pF1KSD EEEEEPQPLPHGREAEGAEE-DGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEA : :.: . . .:. .. ::: :.:.::..... . : .. .. XP_006 EV---PNPDSVTDDLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSC 400 410 420 430 440 450 480 490 500 510 520 530 pF1KSD LWLPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKA : . . . :. .:. . . .: ::. : :. . XP_006 L--STSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPEKSDPSELSWPKSPE- 460 470 480 490 500 510 540 550 560 570 580 590 pF1KSD AFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPS ::... : ..: . : .: : .: . . . : . ..:: XP_006 -------SCSSVAE---SNGVLTEGEESDVESHG--NGLEPGEIPAVPSGERNSF-KVPS 520 530 540 550 600 610 620 630 640 650 pF1KSD TFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASP-FSGEEDVSDPDAL-RPLL ... . . .:: ::::.:::.:::...:::.: :::: .: ::.: . .. .::. XP_006 -IAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEVLSIEEEVEETESWAKPLI 560 570 580 590 600 610 660 670 680 690 700 710 pF1KSD SLQWKNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGEGCPATL : :.... .: ::...::..:: .:.::::::..:: . ....: : .. XP_006 HL-WQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEEND-ARWETKLDEVV 620 630 640 650 660 670 720 730 740 750 760 770 pF1KSD PSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRP :.. ::.:::::::: . :: : : :... .:::: ::.:.:::..:::::::: XP_006 TSEG--KTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPS 680 690 700 710 720 730 780 790 800 810 820 830 pF1KSD ELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERH . . .:: :.:: .::::::::::::::::..: . .: ::.::.::::.:: :: :: XP_006 HEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERT 740 750 760 770 780 790 840 850 860 870 880 890 pF1KSD PVDISAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWP .:.. :: :: ::::..::.:.:.:::::::::: .: .:::::::::::::::::::: XP_006 QIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWP 800 810 820 830 840 850 900 910 920 pF1KSD YVVSITCLKHK---------------------------SG-------GHAVQLL-RAVSL :::.:::..:: .: :: . ...:. XP_006 YVVNITCFRHKVNPNVFTAQSKHSKNESCIATTTSAAAAGATILCELGHKSKACEKVISV 860 870 880 890 900 910 930 940 950 960 970 980 pF1KSD GQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGE ::.::::.:: :: :::....::: ::: :::::.: . .::.:.::::..::::.::: XP_006 GQTVITKHRNTRYYSCRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGE 920 930 940 950 960 970 990 1000 1010 1020 1030 1040 pF1KSD LVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLS .:...: ::.:: ::...: .:.::::::::::...:: ::.::.:::::::..:.: . XP_006 VVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTA 980 990 1000 1010 1020 1030 1050 1060 1070 1080 1090 pF1KSD TGAPQEPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVAFVESLLQVQGRPGAPF . : .: : . ..: : XP_006 SDMRFEDTFYGADIIQGERKRQRVLSSRFKNEYVADPVYRTFLKSSFQKKCQKRQ 1040 1050 1060 1070 1080 >>XP_011526120 (OMIM: 609765) PREDICTED: lysine-specific (429 aa) initn: 2572 init1: 2572 opt: 2572 Z-score: 1405.3 bits: 270.4 E(85289): 1.6e-71 Smith-Waterman score: 2572; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:1-372) 10 20 30 40 50 60 pF1KSD MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD KYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD HKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEE :::::::::::: XP_011 SRASLKAKLLRRPGLLCLDVSTPHGNSRPLQMIDSEEMRVAVSVKLCLQTLKSRSHDFYM 370 380 390 400 410 420 >>XP_016869993 (OMIM: 605469) PREDICTED: lysine-specific (763 aa) initn: 2698 init1: 2109 opt: 2145 Z-score: 1172.2 bits: 228.1 E(85289): 1.5e-58 Smith-Waterman score: 2685; 53.4% identity (73.0% similar) in 789 aa overlap (10-795:11-753) 10 20 30 40 50 pF1KSD MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQT :::::::::::.::::..::::.::.::.:::::::::.:::::::::: XP_016 MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KSD YDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLE :::::...:::::::.:::::::::::::::::::: :.:.:::: ::::::. :..::: XP_016 YDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KSD RKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYF ::::::::::.:::::::.::.::. : .:::. : :.::.::.::: ::::::::::: XP_016 RKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KSD GMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFL ::::::::::::::::::::::::::::::::::::::::::::: ::::.::::::::: XP_016 GMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFL 190 200 210 220 230 240 240 250 260 270 280 290 pF1KSD RHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWID ::::::::: .::::::::..::::::::::::::::::::::::::::::::::.:::: XP_016 RHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWID 250 260 270 280 290 300 300 310 320 330 340 350 pF1KSD YGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWS ::::: :::::::::::::.::: .::.::.:::::::. ..:::.:: ..::...: XP_016 YGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KSD ASRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPE : ... : : . :: :.:: .. .::.. ::: XP_016 QRRRKVR-KASRSFQCARSTSKRPKADE---------------------EEEVSDEVDGA 370 380 390 420 430 440 450 460 470 pF1KSD EEEEEPQPLPHGREAEGAEE-DGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEA : :.: . . .:. .. ::: :.:.::..... . : .. .. XP_016 EV---PNPDSVTDDLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSC 400 410 420 430 440 450 480 490 500 510 520 530 pF1KSD LWLPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKA : . . . :. .:. . . .: ::. : :. . XP_016 L--STSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPEKSDPSELSWPKSPE- 460 470 480 490 500 510 540 550 560 570 580 590 pF1KSD AFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPS ::... : ..: . : .: : .: . . . : . ..:: XP_016 -------SCSSVAE---SNGVLTEGEESDVESHG--NGLEPGEIPAVPSGERNSF-KVPS 520 530 540 550 600 610 620 630 640 650 pF1KSD TFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASP-FSGEEDVSDPDAL-RPLL ... . . .:: ::::.:::.:::...:::.: :::: .: ::.: . .. .::. XP_016 -IAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEVLSIEEEVEETESWAKPLI 560 570 580 590 600 610 660 670 680 690 700 710 pF1KSD SLQWKNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGEGCPATL : :.... .: ::...::..:: .:.::::::..:: . ....: : .. XP_016 HL-WQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEEND-ARWETKLDEVV 620 630 640 650 660 670 720 730 740 750 760 770 pF1KSD PSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRP :.. ::.:::::::: . :: : : :... .:::: ::.:.:::..:::::::: XP_016 TSEG--KTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKCCVRVHASCYGIPS 680 690 700 710 720 730 780 790 800 810 820 830 pF1KSD ELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERH . . .:: :.:: .:::: XP_016 HEICDGWLCARCKRNAWTAVFLEFFIPSC 740 750 760 1096 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 03:54:14 2016 done: Thu Nov 3 03:54:16 2016 Total Scan time: 17.850 Total Display time: 0.390 Function used was FASTA [36.3.4 Apr, 2011]