FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0888, 670 aa 1>>>pF1KSDA0888 670 - 670 aa - 670 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.9963+/-0.000481; mu= 2.1382+/- 0.030 mean_var=195.1969+/-39.804, 0's: 0 Z-trim(115.4): 26 B-trim: 1283 in 1/54 Lambda= 0.091799 statistics sampled from 25888 (25912) to 25888 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.662), E-opt: 0.2 (0.304), width: 16 Scan time: 10.400 The best scores are: opt bits E(85289) XP_005248537 (OMIM: 615769) PREDICTED: soluble lam ( 670) 4359 590.6 6.3e-168 XP_011541608 (OMIM: 615769) PREDICTED: soluble lam ( 670) 4359 590.6 6.3e-168 NP_056381 (OMIM: 615769) soluble lamin-associated ( 670) 4359 590.6 6.3e-168 XP_011541609 (OMIM: 615769) PREDICTED: soluble lam ( 670) 4359 590.6 6.3e-168 XP_016864822 (OMIM: 615769) PREDICTED: soluble lam ( 584) 3273 446.7 1.1e-124 XP_016864821 (OMIM: 615769) PREDICTED: soluble lam ( 646) 3273 446.8 1.2e-124 >>XP_005248537 (OMIM: 615769) PREDICTED: soluble lamin-a (670 aa) initn: 4359 init1: 4359 opt: 4359 Z-score: 3135.8 bits: 590.6 E(85289): 6.3e-168 Smith-Waterman score: 4359; 100.0% identity (100.0% similar) in 670 aa overlap (1-670:1-670) 10 20 30 40 50 60 pF1KSD MAFPVDMLENCSHEELENSAEDYMSDLRCGDPENPECFSLLNITIPISLSNVGFVPLYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAFPVDMLENCSHEELENSAEDYMSDLRCGDPENPECFSLLNITIPISLSNVGFVPLYGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DQTQKILALFAPEDSLTAVALYLADQWWAIDDIVKTSVPSREGLKQVSTLGERVVLYVLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DQTQKILALFAPEDSLTAVALYLADQWWAIDDIVKTSVPSREGLKQVSTLGERVVLYVLN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RIIYRKQEMERNEIPFLCHSSTDYAKILWKKGEAIGFYSVKPTGSICASFLTQSYQLPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIIYRKQEMERNEIPFLCHSSTDYAKILWKKGEAIGFYSVKPTGSICASFLTQSYQLPVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD DTMFLRKKYRGKDFGLHMLEDFVDSFTEDALGLRYPLSSLMYTACKQYFEKYPGDHELLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DTMFLRKKYRGKDFGLHMLEDFVDSFTEDALGLRYPLSSLMYTACKQYFEKYPGDHELLW 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD EVEGVGHWYQRIPVTRALQREALKILALSQNEPKRPMSGEYGPASVPEYEARTEDNQSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EVEGVGHWYQRIPVTRALQREALKILALSQNEPKRPMSGEYGPASVPEYEARTEDNQSSE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MQLTIDSLKDAFASTSEGHDKTSVSTHTRSGNLKRPKIGKRFQDSEFSSSQGEDEKTSQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MQLTIDSLKDAFASTSEGHDKTSVSTHTRSGNLKRPKIGKRFQDSEFSSSQGEDEKTSQT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SLTASINKLESTARPSESSEEFLEEEPEQRGIEFEDESSDRDARPALETQPQQEKQDGEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLTASINKLESTARPSESSEEFLEEEPEQRGIEFEDESSDRDARPALETQPQQEKQDGEK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD ESELEPMNGEIMDDSLKTSLITEEEDSTSEVLDEELKLQPFNSSEDSTNLVPLVVESSKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ESELEPMNGEIMDDSLKTSLITEEEDSTSEVLDEELKLQPFNSSEDSTNLVPLVVESSKP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD PEVDAPDKTPRIPDSEMLMDEGTSDEKGHMEEKLSLLPRKKAHLGSSDNVATMSNEERSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEVDAPDKTPRIPDSEMLMDEGTSDEKGHMEEKLSLLPRKKAHLGSSDNVATMSNEERSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD GGFPNSVIAEFSEEPVSENLSPNTTSSLEDQGEEGVSEPQETSTALPQSSLIEVELEDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGFPNSVIAEFSEEPVSENLSPNTTSSLEDQGEEGVSEPQETSTALPQSSLIEVELEDVP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD FSQNAGQKNQSEEQSEASSEQLDQFTQSAEKAVDSSSEEIEVEVPVVDRRNLRRKAKGHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FSQNAGQKNQSEEQSEASSEQLDQFTQSAEKAVDSSSEEIEVEVPVVDRRNLRRKAKGHK 610 620 630 640 650 660 670 pF1KSD GPAKKKAKLT :::::::::: XP_005 GPAKKKAKLT 670 >>XP_011541608 (OMIM: 615769) PREDICTED: soluble lamin-a (670 aa) initn: 4359 init1: 4359 opt: 4359 Z-score: 3135.8 bits: 590.6 E(85289): 6.3e-168 Smith-Waterman score: 4359; 100.0% identity (100.0% similar) in 670 aa overlap (1-670:1-670) 10 20 30 40 50 60 pF1KSD MAFPVDMLENCSHEELENSAEDYMSDLRCGDPENPECFSLLNITIPISLSNVGFVPLYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAFPVDMLENCSHEELENSAEDYMSDLRCGDPENPECFSLLNITIPISLSNVGFVPLYGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DQTQKILALFAPEDSLTAVALYLADQWWAIDDIVKTSVPSREGLKQVSTLGERVVLYVLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQTQKILALFAPEDSLTAVALYLADQWWAIDDIVKTSVPSREGLKQVSTLGERVVLYVLN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RIIYRKQEMERNEIPFLCHSSTDYAKILWKKGEAIGFYSVKPTGSICASFLTQSYQLPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIIYRKQEMERNEIPFLCHSSTDYAKILWKKGEAIGFYSVKPTGSICASFLTQSYQLPVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD DTMFLRKKYRGKDFGLHMLEDFVDSFTEDALGLRYPLSSLMYTACKQYFEKYPGDHELLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DTMFLRKKYRGKDFGLHMLEDFVDSFTEDALGLRYPLSSLMYTACKQYFEKYPGDHELLW 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD EVEGVGHWYQRIPVTRALQREALKILALSQNEPKRPMSGEYGPASVPEYEARTEDNQSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVEGVGHWYQRIPVTRALQREALKILALSQNEPKRPMSGEYGPASVPEYEARTEDNQSSE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MQLTIDSLKDAFASTSEGHDKTSVSTHTRSGNLKRPKIGKRFQDSEFSSSQGEDEKTSQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQLTIDSLKDAFASTSEGHDKTSVSTHTRSGNLKRPKIGKRFQDSEFSSSQGEDEKTSQT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SLTASINKLESTARPSESSEEFLEEEPEQRGIEFEDESSDRDARPALETQPQQEKQDGEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLTASINKLESTARPSESSEEFLEEEPEQRGIEFEDESSDRDARPALETQPQQEKQDGEK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD ESELEPMNGEIMDDSLKTSLITEEEDSTSEVLDEELKLQPFNSSEDSTNLVPLVVESSKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESELEPMNGEIMDDSLKTSLITEEEDSTSEVLDEELKLQPFNSSEDSTNLVPLVVESSKP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD PEVDAPDKTPRIPDSEMLMDEGTSDEKGHMEEKLSLLPRKKAHLGSSDNVATMSNEERSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEVDAPDKTPRIPDSEMLMDEGTSDEKGHMEEKLSLLPRKKAHLGSSDNVATMSNEERSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD GGFPNSVIAEFSEEPVSENLSPNTTSSLEDQGEEGVSEPQETSTALPQSSLIEVELEDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGFPNSVIAEFSEEPVSENLSPNTTSSLEDQGEEGVSEPQETSTALPQSSLIEVELEDVP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD FSQNAGQKNQSEEQSEASSEQLDQFTQSAEKAVDSSSEEIEVEVPVVDRRNLRRKAKGHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSQNAGQKNQSEEQSEASSEQLDQFTQSAEKAVDSSSEEIEVEVPVVDRRNLRRKAKGHK 610 620 630 640 650 660 670 pF1KSD GPAKKKAKLT :::::::::: XP_011 GPAKKKAKLT 670 >>NP_056381 (OMIM: 615769) soluble lamin-associated prot (670 aa) initn: 4359 init1: 4359 opt: 4359 Z-score: 3135.8 bits: 590.6 E(85289): 6.3e-168 Smith-Waterman score: 4359; 100.0% identity (100.0% similar) in 670 aa overlap (1-670:1-670) 10 20 30 40 50 60 pF1KSD MAFPVDMLENCSHEELENSAEDYMSDLRCGDPENPECFSLLNITIPISLSNVGFVPLYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MAFPVDMLENCSHEELENSAEDYMSDLRCGDPENPECFSLLNITIPISLSNVGFVPLYGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DQTQKILALFAPEDSLTAVALYLADQWWAIDDIVKTSVPSREGLKQVSTLGERVVLYVLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 DQTQKILALFAPEDSLTAVALYLADQWWAIDDIVKTSVPSREGLKQVSTLGERVVLYVLN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RIIYRKQEMERNEIPFLCHSSTDYAKILWKKGEAIGFYSVKPTGSICASFLTQSYQLPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 RIIYRKQEMERNEIPFLCHSSTDYAKILWKKGEAIGFYSVKPTGSICASFLTQSYQLPVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD DTMFLRKKYRGKDFGLHMLEDFVDSFTEDALGLRYPLSSLMYTACKQYFEKYPGDHELLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 DTMFLRKKYRGKDFGLHMLEDFVDSFTEDALGLRYPLSSLMYTACKQYFEKYPGDHELLW 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD EVEGVGHWYQRIPVTRALQREALKILALSQNEPKRPMSGEYGPASVPEYEARTEDNQSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 EVEGVGHWYQRIPVTRALQREALKILALSQNEPKRPMSGEYGPASVPEYEARTEDNQSSE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MQLTIDSLKDAFASTSEGHDKTSVSTHTRSGNLKRPKIGKRFQDSEFSSSQGEDEKTSQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MQLTIDSLKDAFASTSEGHDKTSVSTHTRSGNLKRPKIGKRFQDSEFSSSQGEDEKTSQT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SLTASINKLESTARPSESSEEFLEEEPEQRGIEFEDESSDRDARPALETQPQQEKQDGEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SLTASINKLESTARPSESSEEFLEEEPEQRGIEFEDESSDRDARPALETQPQQEKQDGEK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD ESELEPMNGEIMDDSLKTSLITEEEDSTSEVLDEELKLQPFNSSEDSTNLVPLVVESSKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 ESELEPMNGEIMDDSLKTSLITEEEDSTSEVLDEELKLQPFNSSEDSTNLVPLVVESSKP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD PEVDAPDKTPRIPDSEMLMDEGTSDEKGHMEEKLSLLPRKKAHLGSSDNVATMSNEERSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 PEVDAPDKTPRIPDSEMLMDEGTSDEKGHMEEKLSLLPRKKAHLGSSDNVATMSNEERSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD GGFPNSVIAEFSEEPVSENLSPNTTSSLEDQGEEGVSEPQETSTALPQSSLIEVELEDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GGFPNSVIAEFSEEPVSENLSPNTTSSLEDQGEEGVSEPQETSTALPQSSLIEVELEDVP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD FSQNAGQKNQSEEQSEASSEQLDQFTQSAEKAVDSSSEEIEVEVPVVDRRNLRRKAKGHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 FSQNAGQKNQSEEQSEASSEQLDQFTQSAEKAVDSSSEEIEVEVPVVDRRNLRRKAKGHK 610 620 630 640 650 660 670 pF1KSD GPAKKKAKLT :::::::::: NP_056 GPAKKKAKLT 670 >>XP_011541609 (OMIM: 615769) PREDICTED: soluble lamin-a (670 aa) initn: 4359 init1: 4359 opt: 4359 Z-score: 3135.8 bits: 590.6 E(85289): 6.3e-168 Smith-Waterman score: 4359; 100.0% identity (100.0% similar) in 670 aa overlap (1-670:1-670) 10 20 30 40 50 60 pF1KSD MAFPVDMLENCSHEELENSAEDYMSDLRCGDPENPECFSLLNITIPISLSNVGFVPLYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAFPVDMLENCSHEELENSAEDYMSDLRCGDPENPECFSLLNITIPISLSNVGFVPLYGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DQTQKILALFAPEDSLTAVALYLADQWWAIDDIVKTSVPSREGLKQVSTLGERVVLYVLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQTQKILALFAPEDSLTAVALYLADQWWAIDDIVKTSVPSREGLKQVSTLGERVVLYVLN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RIIYRKQEMERNEIPFLCHSSTDYAKILWKKGEAIGFYSVKPTGSICASFLTQSYQLPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIIYRKQEMERNEIPFLCHSSTDYAKILWKKGEAIGFYSVKPTGSICASFLTQSYQLPVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD DTMFLRKKYRGKDFGLHMLEDFVDSFTEDALGLRYPLSSLMYTACKQYFEKYPGDHELLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DTMFLRKKYRGKDFGLHMLEDFVDSFTEDALGLRYPLSSLMYTACKQYFEKYPGDHELLW 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD EVEGVGHWYQRIPVTRALQREALKILALSQNEPKRPMSGEYGPASVPEYEARTEDNQSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVEGVGHWYQRIPVTRALQREALKILALSQNEPKRPMSGEYGPASVPEYEARTEDNQSSE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MQLTIDSLKDAFASTSEGHDKTSVSTHTRSGNLKRPKIGKRFQDSEFSSSQGEDEKTSQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQLTIDSLKDAFASTSEGHDKTSVSTHTRSGNLKRPKIGKRFQDSEFSSSQGEDEKTSQT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SLTASINKLESTARPSESSEEFLEEEPEQRGIEFEDESSDRDARPALETQPQQEKQDGEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLTASINKLESTARPSESSEEFLEEEPEQRGIEFEDESSDRDARPALETQPQQEKQDGEK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD ESELEPMNGEIMDDSLKTSLITEEEDSTSEVLDEELKLQPFNSSEDSTNLVPLVVESSKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESELEPMNGEIMDDSLKTSLITEEEDSTSEVLDEELKLQPFNSSEDSTNLVPLVVESSKP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD PEVDAPDKTPRIPDSEMLMDEGTSDEKGHMEEKLSLLPRKKAHLGSSDNVATMSNEERSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEVDAPDKTPRIPDSEMLMDEGTSDEKGHMEEKLSLLPRKKAHLGSSDNVATMSNEERSD 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD GGFPNSVIAEFSEEPVSENLSPNTTSSLEDQGEEGVSEPQETSTALPQSSLIEVELEDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGFPNSVIAEFSEEPVSENLSPNTTSSLEDQGEEGVSEPQETSTALPQSSLIEVELEDVP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD FSQNAGQKNQSEEQSEASSEQLDQFTQSAEKAVDSSSEEIEVEVPVVDRRNLRRKAKGHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSQNAGQKNQSEEQSEASSEQLDQFTQSAEKAVDSSSEEIEVEVPVVDRRNLRRKAKGHK 610 620 630 640 650 660 670 pF1KSD GPAKKKAKLT :::::::::: XP_011 GPAKKKAKLT 670 >>XP_016864822 (OMIM: 615769) PREDICTED: soluble lamin-a (584 aa) initn: 3273 init1: 3273 opt: 3273 Z-score: 2359.4 bits: 446.7 E(85289): 1.1e-124 Smith-Waterman score: 3609; 87.2% identity (87.2% similar) in 670 aa overlap (1-670:1-584) 10 20 30 40 50 60 pF1KSD MAFPVDMLENCSHEELENSAEDYMSDLRCGDPENPECFSLLNITIPISLSNVGFVPLYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAFPVDMLENCSHEELENSAEDYMSDLRCGDPENPECFSLLNITIPISLSNVGFVPLYGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD DQTQKILALFAPEDSLTAVALYLADQWWAIDDIVKTSVPSREGLKQVSTLGERVVLYVLN ::::::::::::::::: XP_016 DQTQKILALFAPEDSLT------------------------------------------- 70 130 140 150 160 170 180 pF1KSD RIIYRKQEMERNEIPFLCHSSTDYAKILWKKGEAIGFYSVKPTGSICASFLTQSYQLPVL ::::::::::::::::: XP_016 -------------------------------------------GSICASFLTQSYQLPVL 80 90 190 200 210 220 230 240 pF1KSD DTMFLRKKYRGKDFGLHMLEDFVDSFTEDALGLRYPLSSLMYTACKQYFEKYPGDHELLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTMFLRKKYRGKDFGLHMLEDFVDSFTEDALGLRYPLSSLMYTACKQYFEKYPGDHELLW 100 110 120 130 140 150 250 260 270 280 290 300 pF1KSD EVEGVGHWYQRIPVTRALQREALKILALSQNEPKRPMSGEYGPASVPEYEARTEDNQSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVEGVGHWYQRIPVTRALQREALKILALSQNEPKRPMSGEYGPASVPEYEARTEDNQSSE 160 170 180 190 200 210 310 320 330 340 350 360 pF1KSD MQLTIDSLKDAFASTSEGHDKTSVSTHTRSGNLKRPKIGKRFQDSEFSSSQGEDEKTSQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MQLTIDSLKDAFASTSEGHDKTSVSTHTRSGNLKRPKIGKRFQDSEFSSSQGEDEKTSQT 220 230 240 250 260 270 370 380 390 400 410 420 pF1KSD SLTASINKLESTARPSESSEEFLEEEPEQRGIEFEDESSDRDARPALETQPQQEKQDGEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLTASINKLESTARPSESSEEFLEEEPEQRGIEFEDESSDRDARPALETQPQQEKQDGEK 280 290 300 310 320 330 430 440 450 460 470 480 pF1KSD ESELEPMNGEIMDDSLKTSLITEEEDSTSEVLDEELKLQPFNSSEDSTNLVPLVVESSKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESELEPMNGEIMDDSLKTSLITEEEDSTSEVLDEELKLQPFNSSEDSTNLVPLVVESSKP 340 350 360 370 380 390 490 500 510 520 530 540 pF1KSD PEVDAPDKTPRIPDSEMLMDEGTSDEKGHMEEKLSLLPRKKAHLGSSDNVATMSNEERSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEVDAPDKTPRIPDSEMLMDEGTSDEKGHMEEKLSLLPRKKAHLGSSDNVATMSNEERSD 400 410 420 430 440 450 550 560 570 580 590 600 pF1KSD GGFPNSVIAEFSEEPVSENLSPNTTSSLEDQGEEGVSEPQETSTALPQSSLIEVELEDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGFPNSVIAEFSEEPVSENLSPNTTSSLEDQGEEGVSEPQETSTALPQSSLIEVELEDVP 460 470 480 490 500 510 610 620 630 640 650 660 pF1KSD FSQNAGQKNQSEEQSEASSEQLDQFTQSAEKAVDSSSEEIEVEVPVVDRRNLRRKAKGHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSQNAGQKNQSEEQSEASSEQLDQFTQSAEKAVDSSSEEIEVEVPVVDRRNLRRKAKGHK 520 530 540 550 560 570 670 pF1KSD GPAKKKAKLT :::::::::: XP_016 GPAKKKAKLT 580 >>XP_016864821 (OMIM: 615769) PREDICTED: soluble lamin-a (646 aa) initn: 3273 init1: 3273 opt: 3273 Z-score: 2358.8 bits: 446.8 E(85289): 1.2e-124 Smith-Waterman score: 3609; 87.2% identity (87.2% similar) in 670 aa overlap (1-670:63-646) 10 20 30 pF1KSD MAFPVDMLENCSHEELENSAEDYMSDLRCG :::::::::::::::::::::::::::::: XP_016 WPRPLWVNFRRAYAGLENSTGLCEQNPAKRMAFPVDMLENCSHEELENSAEDYMSDLRCG 40 50 60 70 80 90 40 50 60 70 80 90 pF1KSD DPENPECFSLLNITIPISLSNVGFVPLYGGDQTQKILALFAPEDSLTAVALYLADQWWAI ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPENPECFSLLNITIPISLSNVGFVPLYGGDQTQKILALFAPEDSLT------------- 100 110 120 130 100 110 120 130 140 150 pF1KSD DDIVKTSVPSREGLKQVSTLGERVVLYVLNRIIYRKQEMERNEIPFLCHSSTDYAKILWK XP_016 ------------------------------------------------------------ 160 170 180 190 200 210 pF1KSD KGEAIGFYSVKPTGSICASFLTQSYQLPVLDTMFLRKKYRGKDFGLHMLEDFVDSFTEDA ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 -------------GSICASFLTQSYQLPVLDTMFLRKKYRGKDFGLHMLEDFVDSFTEDA 140 150 160 170 180 220 230 240 250 260 270 pF1KSD LGLRYPLSSLMYTACKQYFEKYPGDHELLWEVEGVGHWYQRIPVTRALQREALKILALSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGLRYPLSSLMYTACKQYFEKYPGDHELLWEVEGVGHWYQRIPVTRALQREALKILALSQ 190 200 210 220 230 240 280 290 300 310 320 330 pF1KSD NEPKRPMSGEYGPASVPEYEARTEDNQSSEMQLTIDSLKDAFASTSEGHDKTSVSTHTRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NEPKRPMSGEYGPASVPEYEARTEDNQSSEMQLTIDSLKDAFASTSEGHDKTSVSTHTRS 250 260 270 280 290 300 340 350 360 370 380 390 pF1KSD GNLKRPKIGKRFQDSEFSSSQGEDEKTSQTSLTASINKLESTARPSESSEEFLEEEPEQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNLKRPKIGKRFQDSEFSSSQGEDEKTSQTSLTASINKLESTARPSESSEEFLEEEPEQR 310 320 330 340 350 360 400 410 420 430 440 450 pF1KSD GIEFEDESSDRDARPALETQPQQEKQDGEKESELEPMNGEIMDDSLKTSLITEEEDSTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GIEFEDESSDRDARPALETQPQQEKQDGEKESELEPMNGEIMDDSLKTSLITEEEDSTSE 370 380 390 400 410 420 460 470 480 490 500 510 pF1KSD VLDEELKLQPFNSSEDSTNLVPLVVESSKPPEVDAPDKTPRIPDSEMLMDEGTSDEKGHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLDEELKLQPFNSSEDSTNLVPLVVESSKPPEVDAPDKTPRIPDSEMLMDEGTSDEKGHM 430 440 450 460 470 480 520 530 540 550 560 570 pF1KSD EEKLSLLPRKKAHLGSSDNVATMSNEERSDGGFPNSVIAEFSEEPVSENLSPNTTSSLED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEKLSLLPRKKAHLGSSDNVATMSNEERSDGGFPNSVIAEFSEEPVSENLSPNTTSSLED 490 500 510 520 530 540 580 590 600 610 620 630 pF1KSD QGEEGVSEPQETSTALPQSSLIEVELEDVPFSQNAGQKNQSEEQSEASSEQLDQFTQSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGEEGVSEPQETSTALPQSSLIEVELEDVPFSQNAGQKNQSEEQSEASSEQLDQFTQSAE 550 560 570 580 590 600 640 650 660 670 pF1KSD KAVDSSSEEIEVEVPVVDRRNLRRKAKGHKGPAKKKAKLT :::::::::::::::::::::::::::::::::::::::: XP_016 KAVDSSSEEIEVEVPVVDRRNLRRKAKGHKGPAKKKAKLT 610 620 630 640 670 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 03:59:26 2016 done: Thu Nov 3 03:59:27 2016 Total Scan time: 10.400 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]