FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0891, 1318 aa 1>>>pF1KSDA0891 1318 - 1318 aa - 1318 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.8734+/-0.000952; mu= 11.4397+/- 0.057 mean_var=148.9079+/-30.883, 0's: 0 Z-trim(111.3): 105 B-trim: 232 in 1/51 Lambda= 0.105103 statistics sampled from 12146 (12254) to 12146 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.712), E-opt: 0.2 (0.376), width: 16 Scan time: 5.940 The best scores are: opt bits E(32554) CCDS43090.1 USP19 gene_id:10869|Hs108|chr3 (1318) 9002 1377.6 0 CCDS56254.1 USP19 gene_id:10869|Hs108|chr3 (1419) 7664 1174.8 0 CCDS56256.1 USP19 gene_id:10869|Hs108|chr3 (1372) 7130 1093.8 0 CCDS56255.1 USP19 gene_id:10869|Hs108|chr3 (1384) 7116 1091.7 0 CCDS2793.1 USP4 gene_id:7375|Hs108|chr3 ( 963) 948 156.3 3.6e-37 CCDS2794.1 USP4 gene_id:7375|Hs108|chr3 ( 916) 947 156.2 3.8e-37 CCDS14277.1 USP11 gene_id:8237|Hs108|chrX ( 963) 886 146.9 2.4e-34 CCDS8963.1 USP15 gene_id:9958|Hs108|chr12 ( 952) 881 146.2 4.1e-34 CCDS58251.1 USP15 gene_id:9958|Hs108|chr12 ( 981) 881 146.2 4.2e-34 CCDS32697.1 USP32 gene_id:84669|Hs108|chr17 (1604) 686 116.7 5e-25 CCDS11069.2 USP6 gene_id:9098|Hs108|chr17 (1406) 678 115.5 1e-24 CCDS61632.1 USP8 gene_id:9101|Hs108|chr15 (1012) 630 108.1 1.2e-22 CCDS10137.1 USP8 gene_id:9101|Hs108|chr15 (1118) 630 108.1 1.3e-22 CCDS8423.1 USP2 gene_id:9099|Hs108|chr11 ( 396) 523 91.7 4.3e-18 CCDS58189.1 USP2 gene_id:9099|Hs108|chr11 ( 362) 515 90.4 9.3e-18 CCDS8422.1 USP2 gene_id:9099|Hs108|chr11 ( 605) 511 89.9 2.2e-17 >>CCDS43090.1 USP19 gene_id:10869|Hs108|chr3 (1318 aa) initn: 9002 init1: 9002 opt: 9002 Z-score: 7378.9 bits: 1377.6 E(32554): 0 Smith-Waterman score: 9002; 100.0% identity (100.0% similar) in 1318 aa overlap (1-1318:1-1318) 10 20 30 40 50 60 pF1KSD MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETGSRYVAQAGLEPLASGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETGSRYVAQAGLEPLASGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD PSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGACEDPHDLLATPTPELLLDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 PSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGACEDPHDLLATPTPELLLDW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD RQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGGQQWGGVFYAEIKSSCAKVQTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 RQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGGQQWGGVFYAEIKSSCAKVQTR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KGSLLHLTLPKKVPMLTWPSLLVEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPPGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 KGSLLHLTLPKKVPMLTWPSLLVEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPPGN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD DPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYEKGPDSVVVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 DPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYEKGPDSVVVH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VYVKEICRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 VYVKEICRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQCT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD FCFTASRIDICLRKRQSQRWGGLEAPAARVGGAKVAVPTGPTPLDSTPPGGAPHPLTGQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 FCFTASRIDICLRKRQSQRWGGLEAPAARVGGAKVAVPTGPTPLDSTPPGGAPHPLTGQE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD EARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSGDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 EARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSGDS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD VEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 VEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD GTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 GTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD HEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 HEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD KVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 KVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD VHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 VHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQR 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD PQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 PQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGY 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD PFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 PFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSLEA 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD GDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 GDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLP 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD AGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 AGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLA 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD LVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 LVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWY 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD CPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 CPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIG 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD QKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 QKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQ 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD VVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQASRIWQELEAEEEPVPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 VVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQASRIWQELEAEEEPVPE 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 pF1KSD GSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 GSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR 1270 1280 1290 1300 1310 >>CCDS56254.1 USP19 gene_id:10869|Hs108|chr3 (1419 aa) initn: 7658 init1: 7658 opt: 7664 Z-score: 6281.9 bits: 1174.8 E(32554): 0 Smith-Waterman score: 8335; 92.5% identity (92.5% similar) in 1350 aa overlap (70-1318:70-1419) 40 50 60 70 80 90 pF1KSD RKETGSRYVAQAGLEPLASGDPSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKE :::::::::::::::::::::::::::::: CCDS56 RKETGSRYVAQAGLEPLASGDPSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKE 40 50 60 70 80 90 100 110 120 130 140 150 pF1KSD GACEDPHDLLATPTPELLLDWRQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 GACEDPHDLLATPTPELLLDWRQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGG 100 110 120 130 140 150 160 170 180 190 200 pF1KSD QQWGGVFYAEIKSSCAKVQTRKGSLLHLTLPKKVPMLTWPSLL----------------- ::::::::::::::::::::::::::::::::::::::::::: CCDS56 QQWGGVFYAEIKSSCAKVQTRKGSLLHLTLPKKVPMLTWPSLLKKPLGTQELVPGLRCQE 160 170 180 190 200 210 pF1KSD ------------------------------------------------------------ CCDS56 NGQELSPIALEPGPEPHRAKQEARNQKRAQGRGEVGAGAGPGAQAGPSAKRAVHLCRGPE 220 230 240 250 260 270 210 220 230 pF1KSD ------------------------VEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPP :::::::::::::::::::::::::::::::::::: CCDS56 GDGSRDDPGPRGDAPPFVADPATQVEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPP 280 290 300 310 320 330 240 250 260 270 280 290 pF1KSD GNDPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYEKGPDSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 GNDPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYEKGPDSVV 340 350 360 370 380 390 300 310 320 330 340 350 pF1KSD VHVYVKEICRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 VHVYVKEICRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQ 400 410 420 430 440 450 360 370 380 390 400 410 pF1KSD CTFCFTASRIDICLRKRQSQRWGGLEAPAARVGGAKVAVPTGPTPLDSTPPGGAPHPLTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 CTFCFTASRIDICLRKRQSQRWGGLEAPAARVGGAKVAVPTGPTPLDSTPPGGAPHPLTG 460 470 480 490 500 510 420 430 440 450 460 470 pF1KSD QEEARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QEEARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSG 520 530 540 550 560 570 480 490 500 510 520 530 pF1KSD DSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 DSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNN 580 590 600 610 620 630 540 550 560 570 580 590 pF1KSD PLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 PLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLD 640 650 660 670 680 690 600 610 620 630 640 650 pF1KSD GLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 GLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPV 700 710 720 730 740 750 660 670 680 690 700 710 pF1KSD CAKVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 CAKVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLS 760 770 780 790 800 810 720 730 740 750 760 770 pF1KSD QSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQ 820 830 840 850 860 870 780 790 800 810 820 830 pF1KSD QRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENI 880 890 900 910 920 930 840 850 860 870 880 890 pF1KSD GYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 GYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSL 940 950 960 970 980 990 900 910 920 930 940 950 pF1KSD EAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 EAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGS 1000 1010 1020 1030 1040 1050 960 970 980 990 1000 1010 pF1KSD LPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCS 1060 1070 1080 1090 1100 1110 1020 1030 1040 1050 1060 1070 pF1KSD LALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEA 1120 1130 1140 1150 1160 1170 1080 1090 1100 1110 1120 1130 pF1KSD WYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 WYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFC 1180 1190 1200 1210 1220 1230 1140 1150 1160 1170 1180 1190 pF1KSD IGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 IGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDE 1240 1250 1260 1270 1280 1290 1200 1210 1220 1230 1240 1250 pF1KSD SQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQASRIWQELEAEEEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 SQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQASRIWQELEAEEEPV 1300 1310 1320 1330 1340 1350 1260 1270 1280 1290 1300 1310 pF1KSD PEGSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 PEGSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR 1360 1370 1380 1390 1400 1410 >-- initn: 455 init1: 455 opt: 455 Z-score: 374.3 bits: 81.7 E(32554): 1.6e-14 Smith-Waterman score: 455; 100.0% identity (100.0% similar) in 69 aa overlap (1-69:1-69) 10 20 30 40 50 60 pF1KSD MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETGSRYVAQAGLEPLASGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETGSRYVAQAGLEPLASGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD PSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGACEDPHDLLATPTPELLLDW ::::::::: CCDS56 PSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGACEDPHDLLATPTPELLLDW 70 80 90 100 110 120 >>CCDS56256.1 USP19 gene_id:10869|Hs108|chr3 (1372 aa) initn: 8384 init1: 7118 opt: 7130 Z-score: 5844.6 bits: 1093.8 E(32554): 0 Smith-Waterman score: 7823; 91.1% identity (91.8% similar) in 1297 aa overlap (60-1264:60-1356) 30 40 50 60 70 80 pF1KSD ANQESKDGDPRKETGSRYVAQAGLEPLASGDPSASASHAAGITGSRHRTRLFFPSSSGSA :::::::::::::::::::::::::::::: CCDS56 ANQESKDGDPRKETGSRYVAQAGLEPLASGDPSASASHAAGITGSRHRTRLFFPSSSGSA 30 40 50 60 70 80 90 100 110 120 130 140 pF1KSD STPQEEQTKEGACEDPHDLLATPTPELLLDWRQSAEEVIVKLRVGVGPLQLEDVDAAFTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 STPQEEQTKEGACEDPHDLLATPTPELLLDWRQSAEEVIVKLRVGVGPLQLEDVDAAFTD 90 100 110 120 130 140 150 160 170 180 190 pF1KSD TDCVVRFAGGQQWGGVFYAEIKSSCAKVQTRKGSLLHLTLPKKV---------------- ::::::::::::::::::::::::::::::::::::::::::: CCDS56 TDCVVRFAGGQQWGGVFYAEIKSSCAKVQTRKGSLLHLTLPKKKKPLGTQELVPGLRCQE 150 160 170 180 190 200 pF1KSD ------------------------------------------------------------ CCDS56 NGQELSPIALEPGPEPHRAKQEARNQKRAQGRGEVGAGAGPGAQAGPSAKRAVHLCRGPE 210 220 230 240 250 260 200 210 220 230 pF1KSD ---------------PMLTWPSLLVEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPP :... :. :::::::::::::::::::::::::::::::::::: CCDS56 GDGSRDDPGPRGDAPPFVADPATQVEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPP 270 280 290 300 310 320 240 250 260 270 280 290 pF1KSD GNDPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYEKGPDSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 GNDPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYEKGPDSVV 330 340 350 360 370 380 300 310 320 330 340 350 pF1KSD VHVYVKEICRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 VHVYVKEICRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQ 390 400 410 420 430 440 360 370 380 390 400 410 pF1KSD CTFCFTASRIDICLRKRQSQRWGGLEAPAARVGGAKVAVPTGPTPLDSTPPGGAPHPLTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 CTFCFTASRIDICLRKRQSQRWGGLEAPAARVGGAKVAVPTGPTPLDSTPPGGAPHPLTG 450 460 470 480 490 500 420 430 440 450 460 470 pF1KSD QEEARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QEEARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSG 510 520 530 540 550 560 480 490 500 510 520 530 pF1KSD DSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 DSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNN 570 580 590 600 610 620 540 550 560 570 580 590 pF1KSD PLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 PLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLD 630 640 650 660 670 680 600 610 620 630 640 650 pF1KSD GLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 GLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPV 690 700 710 720 730 740 660 670 680 690 700 710 pF1KSD CAKVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 CAKVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLS 750 760 770 780 790 800 720 730 740 750 760 770 pF1KSD QSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQ 810 820 830 840 850 860 780 790 800 810 820 830 pF1KSD QRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENI 870 880 890 900 910 920 840 850 860 870 880 890 pF1KSD GYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 GYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSL 930 940 950 960 970 980 900 910 920 930 940 950 pF1KSD EAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 EAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGS 990 1000 1010 1020 1030 1040 960 970 980 990 1000 1010 pF1KSD LPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCS 1050 1060 1070 1080 1090 1100 1020 1030 1040 1050 1060 1070 pF1KSD LALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEA 1110 1120 1130 1140 1150 1160 1080 1090 1100 1110 1120 1130 pF1KSD WYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 WYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFC 1170 1180 1190 1200 1210 1220 1140 1150 1160 1170 1180 1190 pF1KSD IGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 IGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDE 1230 1240 1250 1260 1270 1280 1200 1210 1220 1230 1240 1250 pF1KSD SQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQASRIWQELE-AEEEP :::::::::::::::::::::::::::::::::::::::::::::. : : : . CCDS56 SQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQGLGPGQAPEVAPTRT 1290 1300 1310 1320 1330 1340 1260 1270 1280 1290 1300 1310 pF1KSD VPEGSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRW .:: .: CCDS56 APERFAPPVDRPAPTYSNMEEVD 1350 1360 1370 >>CCDS56255.1 USP19 gene_id:10869|Hs108|chr3 (1384 aa) initn: 7159 init1: 5821 opt: 7116 Z-score: 5833.0 bits: 1091.7 E(32554): 0 Smith-Waterman score: 7774; 90.8% identity (91.1% similar) in 1297 aa overlap (72-1264:72-1368) 50 60 70 80 90 100 pF1KSD ETGSRYVAQAGLEPLASGDPSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGA :::::::::::::::::::::::::::::: CCDS56 ETGSRYVAQAGLEPLASGDPSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGA 50 60 70 80 90 100 110 120 130 140 150 160 pF1KSD CEDPHDLLATPTPELLLDWRQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 CEDPHDLLATPTPELLLDWRQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGGQQ 110 120 130 140 150 160 170 180 190 200 pF1KSD WGGVFYAEIKSSCAKVQTRKGSLLHLTLPKKVPMLTWPSLL------------------- ::::::::::::::::::::::::::::::::::::::::: CCDS56 WGGVFYAEIKSSCAKVQTRKGSLLHLTLPKKVPMLTWPSLLKKPLGTQELVPGLRCQENG 170 180 190 200 210 220 pF1KSD ------------------------------------------------------------ CCDS56 QELSPIALEPGPEPHRAKQEARNQKRAQGRGEVGAGAGPGAQAGPSAKRAVHLCRGPEGD 230 240 250 260 270 280 210 220 230 240 pF1KSD ----------------------VEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPPGN :::::::::::::::::::::::::::::::::::::: CCDS56 GSRDDPGPRGDAPPFVADPATQVEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPPGN 290 300 310 320 330 340 250 260 270 280 290 300 pF1KSD DPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYEKGPDSVVVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 DPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYEKGPDSVVVH 350 360 370 380 390 400 310 320 330 340 350 360 pF1KSD VYVKEICRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 VYVKEICRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQCT 410 420 430 440 450 460 370 380 390 400 410 pF1KSD FCFTASRIDICLRKRQSQRWGGLEAPAAR--VGGAKVAVPTGPTPLDSTPPGGAPHPLTG ::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: CCDS56 FCFTASRIDICLRKRQSQRWGGLEAPAARGAVGGAKVAVPTGPTPLDSTPPGGAPHPLTG 470 480 490 500 510 520 420 430 440 450 460 470 pF1KSD QEEARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QEEARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSG 530 540 550 560 570 580 480 490 500 510 520 530 pF1KSD DSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 DSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNN 590 600 610 620 630 640 540 550 560 570 580 590 pF1KSD PLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 PLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLD 650 660 670 680 690 700 600 610 620 630 640 650 pF1KSD GLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 GLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPV 710 720 730 740 750 760 660 670 680 690 700 710 pF1KSD CAKVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 CAKVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLS 770 780 790 800 810 820 720 730 740 750 760 770 pF1KSD QSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQ 830 840 850 860 870 880 780 790 800 810 820 830 pF1KSD QRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENI 890 900 910 920 930 940 840 850 860 870 880 890 pF1KSD GYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 GYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSL 950 960 970 980 990 1000 900 910 920 930 940 950 pF1KSD EAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 EAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGS 1010 1020 1030 1040 1050 1060 960 970 980 990 1000 1010 pF1KSD LPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCS 1070 1080 1090 1100 1110 1120 1020 1030 1040 1050 1060 1070 pF1KSD LALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEA 1130 1140 1150 1160 1170 1180 1080 1090 1100 1110 1120 1130 pF1KSD WYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 WYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFC 1190 1200 1210 1220 1230 1240 1140 1150 1160 1170 1180 1190 pF1KSD IGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 IGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDE 1250 1260 1270 1280 1290 1300 1200 1210 1220 1230 1240 1250 pF1KSD SQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQASRIWQELE-AEEEP :::::::::::::::::::::::::::::::::::::::::::::. : : : . CCDS56 SQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQGLGPGQAPEVAPTRT 1310 1320 1330 1340 1350 1360 1260 1270 1280 1290 1300 1310 pF1KSD VPEGSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRW .:: .: CCDS56 APERFAPPVDRPAPTYSNMEEVD 1370 1380 >-- initn: 468 init1: 468 opt: 468 Z-score: 385.1 bits: 83.6 E(32554): 4e-15 Smith-Waterman score: 468; 100.0% identity (100.0% similar) in 71 aa overlap (1-71:1-71) 10 20 30 40 50 60 pF1KSD MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETGSRYVAQAGLEPLASGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETGSRYVAQAGLEPLASGD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD PSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGACEDPHDLLATPTPELLLDW ::::::::::: CCDS56 PSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGACEDPHDLLATPTPELLLDW 70 80 90 100 110 120 >>CCDS2793.1 USP4 gene_id:7375|Hs108|chr3 (963 aa) initn: 1357 init1: 856 opt: 948 Z-score: 780.8 bits: 156.3 E(32554): 3.6e-37 Smith-Waterman score: 1382; 35.0% identity (57.6% similar) in 826 aa overlap (413-1227:217-936) 390 400 410 420 430 440 pF1KSD LEAPAARVGGAKVAVPTGPTPLDSTPPGGAPHPLTGQEEARAVEKDKSKARSEDTGLDSV :. : ..... .: : :.. . CCDS27 YMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRNFTTSPK 190 200 210 220 230 240 450 460 470 480 490 pF1KSD ATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVS----GDSVEEEEEEEKKVCL-PGFT .. .:. :. . .. : . :: : : :: : :. . .: . . ::. CCDS27 SSASPYSSVSASLIANGDSTS-TC---GMHSSGVSRGGSGFSASYNCQEPPSSHIQPGLC 250 260 270 280 290 300 500 510 520 530 540 550 pF1KSD GLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRAL :: ::::::::::..: :::: : :.: .::::: .:::: :..: ..: :.. . CCDS27 GLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQM 310 320 330 340 350 360 560 570 580 590 600 610 pF1KSD WKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVD :.: : .:. :. : ::.:: :.:.::..:::::::::::::...::: : : CCDS27 WSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKD 370 380 390 400 410 420 620 630 640 650 660 670 pF1KSD SDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLP ..:::: :::.:::. :..:::: ::: :.: .:: :::: :::::.::::: :: .::: CCDS27 ANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLP 430 440 450 460 470 480 680 690 700 710 720 730 pF1KSD -QKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEVIKN .:..:. :: .:: .: .. :.: ... :.. ..::. . ::. .:.: .. CCDS27 LKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAV-SDLCEALSRLSGIAAENMVVADVYNH 490 500 510 520 530 540 740 750 760 770 780 790 pF1KSD RFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCAACQR :::..: ...:. . : : .. .:. :. . . :.: : : . : : : .: CCDS27 RFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRER-KSRPSSTSSA--- 550 560 570 580 590 800 810 820 830 840 850 pF1KSD KQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARL . : : :.:.::: .:: : CCDS27 ------------SALY--------------------------GQPLLLSVPKHKLTLESL 600 610 860 870 880 890 900 910 pF1KSD AQLLEGYARYSVSVFQP-PFQPGRMALESQSPG-CTTLLSTGSLEAGDSERDPIQPPELQ : . : : : :: : . : :: :: :. : .: :. : : :.. CCDS27 YQAVCD--RISRYVKQPLPDEFGSSPLE---PGACNG--SRNSCEGEDEE-------EME 620 630 640 650 660 920 930 940 950 960 970 pF1KSD LVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEAAVPG . :: : :: .:: : :. :. . . : CCDS27 ---HQEEGKEQL-------------------SETEGSGEDEPGNDPS----ETTQKKIKG 670 680 690 980 990 1000 1010 1020 1030 pF1KSD YQHPSEAMN-AHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFV :.. .. . . .. :.: . .: :.:.. .::. : .. : . CCDS27 QPCPKRLFTFSLVNSYGTADINSLAADGKL-------LKLNSRSTLAMDWDSETRRLYY- 700 710 720 730 740 750 1040 1050 1060 1070 1080 1090 pF1KSD LVASKELECAEDPGSAGEAARAGHFT--LDQCLNLFTRPEVLAPEEAWYCPQCKQHREAS .: : : : . . . : : .:..::: :.:. .. ::::.::.:..:. CCDS27 --DEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQAT 760 770 780 790 800 1100 1110 1120 1130 1140 1150 pF1KSD KQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDL :.. :: ::..:.:.:::::. . ::::.. .::::.:.:..:.: . . . ::: CCDS27 KKFDLWSLPKILVVHLKRFSYNRY-WRDKLDTVVEFPIRGLNMSEFVCNLSARPY-VYDL 810 820 830 840 850 860 1160 1170 1180 1190 1200 1210 pF1KSD YAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFY :: ::::.: ::::: :. : ... : ::::.:. ..:.:.::. :::::: CCDS27 IAVSNHYGAMGVGHYTAYAK--NKLNGK-----WYYFDDSNVSLASEDQIVTKAAYVLFY 870 880 890 900 910 920 1220 1230 1240 1250 1260 1270 pF1KSD RRRNSPVERPPRAGHSEHHPDLGPAAEAAASQASRIWQELEAEEEPVPEGSGPLGPWGPQ .::.. . : . : CCDS27 QRRDDEFYKTPSLSSSGSSDGGTRPSSSQQGFGDDEACSMDTN 930 940 950 960 >>CCDS2794.1 USP4 gene_id:7375|Hs108|chr3 (916 aa) initn: 1357 init1: 856 opt: 947 Z-score: 780.3 bits: 156.2 E(32554): 3.8e-37 Smith-Waterman score: 1381; 36.8% identity (59.1% similar) in 741 aa overlap (494-1227:252-889) 470 480 490 500 510 520 pF1KSD PTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRD ::. :: ::::::::::..: :::: : : CCDS27 GTWPRQTLQSNGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTD 230 240 250 260 270 280 530 540 550 560 570 580 pF1KSD FFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG .: .::::: .:::: :..: ..: :.. .:.: : .:. :. : ::.: CCDS27 YFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSG 290 300 310 320 330 340 590 600 610 620 630 640 pF1KSD YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIV : :.:.::..:::::::::::::...::: : :..:::: :::.:::. :..:::: :: CCDS27 YQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIV 350 360 370 380 390 400 650 660 670 680 690 700 pF1KSD DLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLP-QKQKVLPVFYFAREPHSKPIKFLVS : :.: .:: :::: :::::.::::: :: .::: .:..:. :: .:: .: .. :. CCDS27 DTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVT 410 420 430 440 450 460 710 720 730 740 750 760 pF1KSD VSKENSTASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFEL : ... :.. ..::. . ::. .:.: ..:::..: ...:. . : : .. .:. CCDS27 VPLMGAV-SDLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEV 470 480 490 500 510 520 770 780 790 800 810 820 pF1KSD LSSELAKERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQ :. . . :.: : : . : : : .: . : CCDS27 CSTSVDGSECVTLPVYFRER-KSRPSSTSSA---------------SALY---------- 530 540 550 830 840 850 860 870 880 pF1KSD KTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQP-PFQPGRMA : :.:.::: .:: : : . : : : :: : . : CCDS27 ----------------GQPLLLSVPKHKLTLESLYQAVCD--RISRYVKQPLPDEFGSSP 560 570 580 590 890 900 910 920 930 940 pF1KSD LESQSPG-CTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPS :: :: :. : .: :. : : :.. . :: : CCDS27 LE---PGACNG--SRNSCEGEDEE-------EME---HQEEGKEQL-------------- 600 610 620 950 960 970 980 990 pF1KSD TSGISSEMLASGPIEVGSLPAGERVSRPEAAVPGYQHPSEAMN-AHTPQFFIYKIDSSNR :: .:: : :. :. : ... . : :.. .. . . .. :.: CCDS27 -----SETEGSGEDEPGNDPS-ETTQKK---IKGQPCPKRLFTFSLVNSYGTADINSLAA 630 640 650 660 670 1000 1010 1020 1030 1040 1050 pF1KSD EQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFT . .: :.:.. .::. : .. : . .: : : : . . . : CCDS27 DGKL-------LKLNSRSTLAMDWDSETRRLYY---DEQESEAYEKHVSMLQPQKKKKTT 680 690 700 710 720 1060 1070 1080 1090 1100 1110 pF1KSD --LDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIW : .:..::: :.:. .. ::::.::.:..:.:.. :: ::..:.:.:::::. . : CCDS27 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY-W 730 740 750 760 770 780 1120 1130 1140 1150 1160 1170 pF1KSD RDKINDLVEFPVRNLDLSKF-CIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDR :::.. .::::.:.:..:.: : . . . ::: :: ::::.: ::::: :. CCDS27 RDKLDTVVEFPIRGLNMSEFVCNLSARPYV--YDLIAVSNHYGAMGVGHYTAYAK----- 790 800 810 820 830 840 1180 1190 1200 1210 1220 1230 pF1KSD SSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPA .. . : ::::.:. ..:.:.::. ::::::.::.. . : . : CCDS27 --NKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRP 850 860 870 880 890 1240 1250 1260 1270 1280 1290 pF1KSD AEAAASQASRIWQELEAEEEPVPEGSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVLGT CCDS27 SSSQQGFGDDEACSMDTN 900 910 >>CCDS14277.1 USP11 gene_id:8237|Hs108|chrX (963 aa) initn: 1300 init1: 800 opt: 886 Z-score: 730.0 bits: 146.9 E(32554): 2.4e-34 Smith-Waterman score: 1349; 35.2% identity (59.5% similar) in 782 aa overlap (470-1245:284-956) 440 450 460 470 480 490 pF1KSD DSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGL : . : .... ::.:. : ::. :: CCDS14 LYDTHITVLDAALETGQLIIMETRKKDGTWPSAQLHVMNNNMSEEDEDFKG--QPGICGL 260 270 280 290 300 310 500 510 520 530 540 550 pF1KSD VNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWK .::::::::::..: :::. .: ..: . . :.:. :::: :..: ..: :.. :. CCDS14 TNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWS 320 330 340 350 360 370 560 570 580 590 600 610 pF1KSD GTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD : :... : .: :. :::: :: :::.::...::::::::::::...: :.: :. CCDS14 GHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAA 380 390 400 410 420 430 620 630 640 650 660 670 pF1KSD GRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLP-Q ::::. ::.:::: :: :::: ::: :.: .:: :::: :..::.::::: :: :::: . CCDS14 GRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPIS 440 450 460 470 480 490 680 690 700 710 720 730 pF1KSD KQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEVIKNRF ...:: ::.. .:. :: . . : :... :.. .::. . ..:: . .:.:...:: CCDS14 HKRVLEVFFIPMDPRRKPEQHRLVVPKKGKI-SDLCVALSKHTGISPERMMVADVFSHRF 500 510 520 530 540 550 740 750 760 770 780 790 pF1KSD HRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCAACQRKQ .... . :... : .. .:. . :. ..: ... : ::. ... CCDS14 YKLYQLEEPLSSILDRDDIFVYEVSG------RIEAIEGSREDIV--VPVY----LRERT 560 570 580 590 800 810 820 830 840 850 pF1KSD QSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQ ..: : :. . :: .:.:.::::: .:.:. : . CCDS14 PARD-------------YNNS---------YYGLML---FGHPLLVSVPRDRFTWEGLYN 600 610 620 630 860 870 880 890 900 910 pF1KSD LLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSLEAGDSERDPIQPPELQLVTP .: . : : : .: .... : : :.:.: . : : CCDS14 VL--MYRLSRYVTKP-------NSDDEDDGD---------EKEDDEEDKDDVP-----GP 640 650 660 670 920 930 940 950 960 970 pF1KSD MAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEAAVPGYQHP . :. : : : .: :: . :. . . . : : CCDS14 STGGSL----------RDPEPEQAGPSSGVTNRCPFLL------------DNCLGTSQWP 680 690 700 980 990 1000 1010 1020 1030 pF1KSD SEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASK . . :.: . .:: . :. .: :. . .:. :. . . . . : CCDS14 PR---RRRKQLFTLQTVNSNGTS---DRTTSPEEVHAQPYIAIDWEPEMKKRYYDEV--- 710 720 730 740 750 1040 1050 1060 1070 1080 1090 pF1KSD ELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWR : : .: . . . :..:..::: :.: :. ::::.::::. :.:.: :: CCDS14 EAEGYVKHDCVGYVMKKAPVRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWM 760 770 780 790 800 810 1100 1110 1120 1130 1140 1150 pF1KSD LPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLP---SYDLYAVI ::..::..:::::. .: :.:.. :::::.:.::.:.: : ..:. : .::: :: CCDS14 LPEILIIHLKRFSYTKFS-REKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVS 820 830 840 850 860 870 1160 1170 1180 1190 1200 1210 pF1KSD NHYGGMIGGHYT--ACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRR :::::: :::: :: : :.: :. :::..:. :.:.:. .. ::::::.: CCDS14 NHYGGMRDGHYTTFAC----NKDSGQ-----WHYFDDNSVSPVNENQIESKAAYVLFYQR 880 890 900 910 920 1220 1230 1240 1250 1260 1270 pF1KSD RNSPVERPPRAGHSEHHPDLGPAAEAAASQASRIWQELEAEEEPVPEGSGPLGPWGPQDW .. . :: : .::. : .: : CCDS14 QDVARRLLSPAGSSG-----APASPACSSPPSSEFMDVN 930 940 950 960 1280 1290 1300 1310 pF1KSD VGPLPRGPTTPDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR >>CCDS8963.1 USP15 gene_id:9958|Hs108|chr12 (952 aa) initn: 1340 init1: 830 opt: 881 Z-score: 726.0 bits: 146.2 E(32554): 4.1e-34 Smith-Waterman score: 1345; 35.8% identity (60.0% similar) in 732 aa overlap (494-1216:257-906) 470 480 490 500 510 520 pF1KSD PTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRD ::. :: ::::::::::.:: :::: : . CCDS89 PNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTE 230 240 250 260 270 280 530 540 550 560 570 580 pF1KSD FFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG .: . ... :.:..:::: :..: ..: :.. .:.: : .:. :. : ::.: CCDS89 YFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSG 290 300 310 320 330 340 590 600 610 620 630 640 pF1KSD YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIV : :.: ::..::::::::::::::..::: . :.:::::.:::::::. : ::::.:: CCDS89 YQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIV 350 360 370 380 390 400 650 660 670 680 690 700 pF1KSD DLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLP-QKQKVLPVFYFAREPHSKPIKFLVS :.:.: .:: :::: :::.:.::::: :: .::: .:...: :. .: .::... : CCDS89 DIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVV 410 420 430 440 450 460 710 720 730 740 750 760 pF1KSD VSKENSTASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFEL : : .. .. .:: . ... .... ..::::.: ...:... : . ::. CCDS89 VPKIGNIL-DLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEI 470 480 490 500 510 520 770 780 790 800 810 820 pF1KSD -LSSELAKERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLC .. :.:. .:. : : ::... . CCDS89 NINRTEDTEHVI------------IPV-----CLR------EKFRHSSY----------- 530 540 550 830 840 850 860 870 880 pF1KSD QKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMA :: : : .: :::..:: . :: . :: :.. . CCDS89 --TH---HTG---SSLFGQPFLMAVPRNNTEDKLYNLLLLRMCRY-VKISTETEE----- 560 570 580 590 890 900 910 920 930 pF1KSD LESQSPGCTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEG--DTGLP---RVWAAPDR- :.. : .:. : :. .: :.. : :. : :: . . : CCDS89 TEGSLHCCKDQNINGNGPNGIHEEG--SPSEMETDEPDDESSQDQELPSENENSQSEDSV 600 610 620 630 640 650 940 950 960 970 980 990 pF1KSD -GPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKI : : .:. .: .: . .:.. .: . .: .. :. : : CCDS89 GGDNDSENGLCTEDTCKGQL------TGHK-KR----LFTFQF-NNLGNTD-----INYI 660 670 680 690 1000 1010 1020 1030 1040 1050 pF1KSD DSSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAAR ...:. :..:. :.: . ::: : . . . : :....: : . . . CCDS89 KDDTRHIRFDDR---QLRLDERSFLALDWDPDLKKRYFDENAAEDFEKHE--SVEYKPPK 700 710 720 730 740 750 1060 1070 1080 1090 1100 1110 pF1KSD AGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRS : .:..::: : :. :. ::::.::.:..:.:.: :: :: ::.:.:::::. CCDS89 KPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSR 760 770 780 790 800 810 1120 1130 1140 1150 1160 1170 pF1KSD FIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPN .. :::.. ::.::. .::.:.: :. . :.: :: :::::: :::::: :. CCDS89 YM-RDKLDTLVDFPINDLDMSEFLINPNAGPC-RYNLIAVSNHYGGMGGGHYTAFAK--- 820 830 840 850 860 1180 1190 1200 1210 1220 1230 pF1KSD DRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLG ...: : ::::.:.:..:.:.:.. ::::::.:... CCDS89 ----NKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQDTFSGTGFFPLDRETKGASA 870 880 890 900 910 920 1240 1250 1260 1270 1280 1290 pF1KSD PAAEAAASQASRIWQELEAEEEPVPEGSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVL CCDS89 ATGIPLESDEDSNDNDNDIENENCMHTN 930 940 950 >>CCDS58251.1 USP15 gene_id:9958|Hs108|chr12 (981 aa) initn: 1340 init1: 830 opt: 881 Z-score: 725.8 bits: 146.2 E(32554): 4.2e-34 Smith-Waterman score: 1345; 35.8% identity (60.0% similar) in 732 aa overlap (494-1216:286-935) 470 480 490 500 510 520 pF1KSD PTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRD ::. :: ::::::::::.:: :::: : . CCDS58 RNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTE 260 270 280 290 300 310 530 540 550 560 570 580 pF1KSD FFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG .: . ... :.:..:::: :..: ..: :.. .:.: : .:. :. : ::.: CCDS58 YFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSG 320 330 340 350 360 370 590 600 610 620 630 640 pF1KSD YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIV : :.: ::..::::::::::::::..::: . :.:::::.:::::::. : ::::.:: CCDS58 YQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIV 380 390 400 410 420 430 650 660 670 680 690 700 pF1KSD DLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLP-QKQKVLPVFYFAREPHSKPIKFLVS :.:.: .:: :::: :::.:.::::: :: .::: .:...: :. .: .::... : CCDS58 DIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERTLEVYLVRMDPLTKPMQYKVV 440 450 460 470 480 490 710 720 730 740 750 760 pF1KSD VSKENSTASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFEL : : .. .. .:: . ... .... ..::::.: ...:... : . ::. CCDS58 VPKIGNIL-DLCTALSALSGIPADKMIVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEI 500 510 520 530 540 550 770 780 790 800 810 820 pF1KSD -LSSELAKERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLC .. :.:. .:. : : ::... . CCDS58 NINRTEDTEHVI------------IPV-----CLR------EKFRHSSY----------- 560 570 580 830 840 850 860 870 880 pF1KSD QKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMA :: : : .: :::..:: . :: . :: :.. . CCDS58 --TH---HTG---SSLFGQPFLMAVPRNNTEDKLYNLLLLRMCRY-VKISTETEE----- 590 600 610 620 890 900 910 920 930 pF1KSD LESQSPGCTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEG--DTGLP---RVWAAPDR- :.. : .:. : :. .: :.. : :. : :: . . : CCDS58 TEGSLHCCKDQNINGNGPNGIHEEG--SPSEMETDEPDDESSQDQELPSENENSQSEDSV 630 640 650 660 670 680 940 950 960 970 980 990 pF1KSD -GPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKI : : .:. .: .: . .:.. .: . .: .. :. : : CCDS58 GGDNDSENGLCTEDTCKGQL------TGHK-KR----LFTFQF-NNLGNTD-----INYI 690 700 710 720 1000 1010 1020 1030 1040 1050 pF1KSD DSSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAAR ...:. :..:. :.: . ::: : . . . : :....: : . . . CCDS58 KDDTRHIRFDDR---QLRLDERSFLALDWDPDLKKRYFDENAAEDFEKHE--SVEYKPPK 730 740 750 760 770 780 1060 1070 1080 1090 1100 1110 pF1KSD AGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRS : .:..::: : :. :. ::::.::.:..:.:.: :: :: ::.:.:::::. CCDS58 KPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSR 790 800 810 820 830 840 1120 1130 1140 1150 1160 1170 pF1KSD FIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPN .. :::.. ::.::. .::.:.: :. . :.: :: :::::: :::::: :. CCDS58 YM-RDKLDTLVDFPINDLDMSEFLINPNAGPC-RYNLIAVSNHYGGMGGGHYTAFAK--- 850 860 870 880 890 1180 1190 1200 1210 1220 1230 pF1KSD DRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLG ...: : ::::.:.:..:.:.:.. ::::::.:... CCDS58 ----NKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQDTFSGTGFFPLDRETKGASA 900 910 920 930 940 950 1240 1250 1260 1270 1280 1290 pF1KSD PAAEAAASQASRIWQELEAEEEPVPEGSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVL CCDS58 ATGIPLESDEDSNDNDNDIENENCMHTN 960 970 980 >>CCDS32697.1 USP32 gene_id:84669|Hs108|chr17 (1604 aa) initn: 982 init1: 668 opt: 686 Z-score: 562.8 bits: 116.7 E(32554): 5e-25 Smith-Waterman score: 801; 30.2% identity (54.9% similar) in 705 aa overlap (448-1139:687-1313) 420 430 440 450 460 470 pF1KSD GQEEARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASP-KPTCMVPPMPHSPV .:.. . : ::. . : : : . CCDS32 QRLRIKEEDMRLWLYNSENYLTLLDDEDHKLEYLKIQDEQHLVIEVRNKDMSWPEEMSFI 660 670 680 690 700 710 480 490 500 510 520 530 pF1KSD SGDS-VEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEIN ...: ..... .: : ::: :::::::::: :: .:::. : ..: . :.: CCDS32 ANSSKIDRHKVPTEK----GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELN 720 730 740 750 760 770 540 550 560 570 580 590 pF1KSD YNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAF .::.: :..: .. :.. ::.::.. : ::. .:. : .:.:. :.:.::..:: CCDS32 RTNPIGMKGHMAKCYGDLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAF 780 790 800 810 820 830 600 610 620 630 640 650 pF1KSD LLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLV :::::::::::...:::.: ::::::: :: :::. : :: :..::::.:: .:.. CCDS32 LLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVK 840 850 860 870 880 890 660 670 680 690 700 710 pF1KSD CPVCAKVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLD : .:...:. :::: .: .:::. . . . . . :... . .. ... .. . CCDS32 CKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLDGTTPVRYGLRLNMDEKYTG-LKK 900 910 920 930 940 950 720 730 740 750 760 770 pF1KSD SLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVL .::. .. :.. :::: . . . : ... .: : : ::. CCDS32 QLSDLCGLNSEQILLAEVHGSNI-KNFPQDNQKVRLSVSGFLCAFEI------------- 960 970 980 990 780 790 800 810 820 830 pF1KSD EVQQRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRP : :: ::: . : .: :.. : : : :: CCDS32 -----P-VPVSPISASSPTQTDFSSSPST-------------NEMFTLTTNGD---LPRP 1000 1010 1020 1030 840 850 860 870 880 890 pF1KSD ENI--GYPFLVSVPASRLTYARLAQ-LLEGYARYSVSVFQPPFQPGRMALESQSPGCTTL : :.: : :: . : ... ...:. :. . :: .:.. . . CCDS32 IFIPNGMPNTV-VPCG--TEKNFTNGMVNGHMP---SLPDSPFTGYIIAVHRK------M 1040 1050 1060 1070 1080 900 910 920 930 940 pF1KSD LSTGSLEAGDSERDPIQPPELQLVTP---MAEGDTGLPRVWAAPDRGPVPSTSGISSEML . : : .:... . . :..: .. :: .: : .:. CCDS32 MRT-ELYFLSSQKNRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSRLASPLPPQEASNHA 1090 1100 1110 1120 1130 1140 950 960 970 980 990 1000 pF1KSD ASGPIEVG-SLPAGERVSRPEAAVPGYQHPSEAMNAHTPQF-FIY--KIDSSNREQRLED . .: . : :: . .. : : . : ::: .. . . CCDS32 QDCDDSMGYQYPFTLRVVQKDGNS----------CAWCPWYRFCRGCKIDCGEDRAFI-- 1150 1160 1170 1180 1190 1010 1020 1030 1040 1050 1060 pF1KSD KGDTPLELG-DDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCL :.. . . : .: : .... :: :. : : .:. .. :.: ..::.:: CCDS32 -GNAYIAVDWDPTALHLRYQTS---QERVV---DEHESVEQ----SRRAQAEPINLDSCL 1200 1210 1220 1230 1070 1080 1090 1100 1110 1120 pF1KSD NLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDL :: : :. .: .:: .:: : :.:.: ::::: .::..::::.: . : : . . CCDS32 RAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWI-KSQKI 1240 1250 1260 1270 1280 1290 1130 1140 1150 1160 1170 1180 pF1KSD VEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVG :.:: ...: : : . CCDS32 VKFPRESFDPSAFLVPRDPALCQHKPLTPQGDELSEPRILAREVKKVDAQSSAGEEDVLL 1300 1310 1320 1330 1340 1350 1318 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 18:50:48 2016 done: Thu Nov 3 18:50:49 2016 Total Scan time: 5.940 Total Display time: 0.590 Function used was FASTA [36.3.4 Apr, 2011]