FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0920, 1103 aa 1>>>pF1KSDA0920 1103 - 1103 aa - 1103 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.8085+/-0.00038; mu= -1.5498+/- 0.024 mean_var=284.5464+/-57.044, 0's: 0 Z-trim(122.3): 9 B-trim: 19 in 1/58 Lambda= 0.076032 statistics sampled from 40149 (40159) to 40149 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.755), E-opt: 0.2 (0.471), width: 16 Scan time: 14.250 The best scores are: opt bits E(85289) NP_001185585 (OMIM: 604582) A-kinase anchor protei ( 961) 5989 670.9 9.9e-192 NP_001004065 (OMIM: 604582) A-kinase anchor protei ( 948) 5708 640.1 1.9e-182 NP_001130034 (OMIM: 604582) A-kinase anchor protei ( 859) 5457 612.5 3.3e-174 NP_060204 (OMIM: 610182) palmdelphin [Homo sapiens ( 551) 391 56.7 4.4e-07 XP_005259623 (OMIM: 608134) PREDICTED: paralemmin- ( 386) 368 54.1 1.9e-06 NP_002570 (OMIM: 608134) paralemmin-1 isoform 1 [H ( 387) 368 54.1 1.9e-06 XP_005259622 (OMIM: 608134) PREDICTED: paralemmin- ( 389) 368 54.1 1.9e-06 NP_001035224 (OMIM: 608134) paralemmin-1 isoform 2 ( 343) 351 52.2 6.2e-06 XP_016882339 (OMIM: 608134) PREDICTED: paralemmin- ( 345) 351 52.2 6.3e-06 >>NP_001185585 (OMIM: 604582) A-kinase anchor protein 2 (961 aa) initn: 5989 init1: 5989 opt: 5989 Z-score: 3563.2 bits: 670.9 E(85289): 9.9e-192 Smith-Waterman score: 5996; 96.7% identity (97.3% similar) in 950 aa overlap (155-1103:22-961) 130 140 150 160 170 180 pF1KSD GFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAGVGWENVLLKEGESASNAT ::: ::. : : .. . NP_001 MRWPQPGAAARLPPESPGPPESPGPPEREAAAARRW------TGAEPQDCA 10 20 30 40 190 200 210 220 230 240 pF1KSD ETSG-PDMTIKKPPQLSEDDIWLKSEGDNYSATLLEPAASSLSPDHKNMEIEVSVAECKS :: :. ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGSGRPE----KPPQLSEDDIWLKSEGDNYSATLLEPAASSLSPDHKNMEIEVSVAECKS 50 60 70 80 90 100 250 260 270 280 290 300 pF1KSD VPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEANCCDSAVDGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEANCCDSAVDGT 110 120 130 140 150 160 310 320 330 340 350 360 pF1KSD YNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTN 170 180 190 200 210 220 370 380 390 400 410 420 pF1KSD GHSPSQPRDALGDSLQVPVSPSSTTSSRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHSPSQPRDALGDSLQVPVSPSSTTSSRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSK 230 240 250 260 270 280 430 440 450 460 470 480 pF1KSD LFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEE 290 300 310 320 330 340 490 500 510 520 530 540 pF1KSD QLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKA 350 360 370 380 390 400 550 560 570 580 590 600 pF1KSD KEDIVTEQIDFSAARKQFQLMENSRQAVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEDIVTEQIDFSAARKQFQLMENSRQAVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPR 410 420 430 440 450 460 610 620 630 640 650 660 pF1KSD PPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSKRGPLSKLWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSKRGPLSKLWA 470 480 490 500 510 520 670 680 690 700 710 720 pF1KSD EDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLS 530 540 550 560 570 580 730 740 750 760 770 780 pF1KSD NDFSMDNISDSGASNETTNALQENSLADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDFSMDNISDSGASNETTNALQENSLADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSP 590 600 610 620 630 640 790 800 810 820 830 840 pF1KSD SSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGPEATVEEAEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGPEATVEEAEA 650 660 670 680 690 700 850 860 870 880 890 900 pF1KSD AAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINME 710 720 730 740 750 760 910 920 930 940 950 960 pF1KSD ETRPEGSYFSKYSEAAELRSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETRPEGSYFSKYSEAAELRSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQER 770 780 790 800 810 820 970 980 990 1000 1010 1020 pF1KSD EEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAP 830 840 850 860 870 880 1030 1040 1050 1060 1070 1080 pF1KSD EEAAGTQRPKNLMQTLMEDYETHKSKRRERMDDSSYTSKLLSCKVTSEVLEATRVNRRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEAAGTQRPKNLMQTLMEDYETHKSKRRERMDDSSYTSKLLSCKVTSEVLEATRVNRRKS 890 900 910 920 930 940 1090 1100 pF1KSD ALALRWEAGIYANQEEEDNE :::::::::::::::::::: NP_001 ALALRWEAGIYANQEEEDNE 950 960 >>NP_001004065 (OMIM: 604582) A-kinase anchor protein 2 (948 aa) initn: 5708 init1: 5708 opt: 5708 Z-score: 3396.7 bits: 640.1 E(85289): 1.9e-182 Smith-Waterman score: 5881; 95.4% identity (95.9% similar) in 950 aa overlap (155-1103:22-948) 130 140 150 160 170 180 pF1KSD GFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAGVGWENVLLKEGESASNAT ::: ::. : : .. . NP_001 MRWPQPGAAARLPPESPGPPESPGPPEREAAAARRW------TGAEPQDCA 10 20 30 40 190 200 210 220 230 240 pF1KSD ETSG-PDMTIKKPPQLSEDDIWLKSEGDNYSATLLEPAASSLSPDHKNMEIEVSVAECKS :: :. ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGSGRPE----KPPQLSEDDIWLKSEGDNYSATLLEPAASSLSPDHKNMEIEVSVAECKS 50 60 70 80 90 100 250 260 270 280 290 300 pF1KSD VPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEANCCDSAVDGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEANCCDSAVDGT 110 120 130 140 150 160 310 320 330 340 350 360 pF1KSD YNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTN 170 180 190 200 210 220 370 380 390 400 410 420 pF1KSD GHSPSQPRDALGDSLQVPVSPSSTTSSRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHSPSQPRDALGDSLQVPVSPSSTTSSRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSK 230 240 250 260 270 280 430 440 450 460 470 480 pF1KSD LFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEE 290 300 310 320 330 340 490 500 510 520 530 540 pF1KSD QLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKA 350 360 370 380 390 400 550 560 570 580 590 600 pF1KSD KEDIVTEQIDFSAARKQFQLMENSRQAVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEDIVTEQIDFSAARKQFQLMENSRQAVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPR 410 420 430 440 450 460 610 620 630 640 650 660 pF1KSD PPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSKRGPLSKLWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSKRGPLSKLWA 470 480 490 500 510 520 670 680 690 700 710 720 pF1KSD EDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLS 530 540 550 560 570 580 730 740 750 760 770 780 pF1KSD NDFSMDNISDSGASNETTNALQENSLADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDFSMDNISDSGASNETTNALQENSLADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSP 590 600 610 620 630 640 790 800 810 820 830 840 pF1KSD SSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGPEATVEEAEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGPEATVEEAEA 650 660 670 680 690 700 850 860 870 880 890 900 pF1KSD AAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINME 710 720 730 740 750 760 910 920 930 940 950 960 pF1KSD ETRPEGSYFSKYSEAAELRSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETRPEGSYFSKYSEAAELRSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQER 770 780 790 800 810 820 970 980 990 1000 1010 1020 pF1KSD EEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAP 830 840 850 860 870 880 1030 1040 1050 1060 1070 1080 pF1KSD EEAAGTQRPKNLMQTLMEDYETHKSKRRERMDDSSYTSKLLSCKVTSEVLEATRVNRRKS ::::::::::::::::::::::::::::::::::: :::::::::::: NP_001 EEAAGTQRPKNLMQTLMEDYETHKSKRRERMDDSS-------------VLEATRVNRRKS 890 900 910 920 1090 1100 pF1KSD ALALRWEAGIYANQEEEDNE :::::::::::::::::::: NP_001 ALALRWEAGIYANQEEEDNE 930 940 >>NP_001130034 (OMIM: 604582) A-kinase anchor protein 2 (859 aa) initn: 5457 init1: 5457 opt: 5457 Z-score: 3248.5 bits: 612.5 E(85289): 3.3e-174 Smith-Waterman score: 5623; 98.5% identity (98.5% similar) in 872 aa overlap (232-1103:1-859) 210 220 230 240 250 260 pF1KSD DDIWLKSEGDNYSATLLEPAASSLSPDHKNMEIEVSVAECKSVPGITSTPHPMDHPSAFY :::::::::::::::::::::::::::::: NP_001 MEIEVSVAECKSVPGITSTPHPMDHPSAFY 10 20 30 270 280 290 300 310 320 pF1KSD SPPHNGLLTDHHESLDNDVAREIRYLDEVLEANCCDSAVDGTYNGTSSPEPGAVVLVGGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPPHNGLLTDHHESLDNDVAREIRYLDEVLEANCCDSAVDGTYNGTSSPEPGAVVLVGGL 40 50 60 70 80 90 330 340 350 360 370 380 pF1KSD SPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVP 100 110 120 130 140 150 390 400 410 420 430 440 pF1KSD VSPSSTTSSRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSPSSTTSSRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVR 160 170 180 190 200 210 450 460 470 480 490 500 pF1KSD PSEEMLELEKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEEQLDEEHLESHKKYKERKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSEEMLELEKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEEQLDEEHLESHKKYKERKE 220 230 240 250 260 270 510 520 530 540 550 560 pF1KSD RRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKAKEDIVTEQIDFSAARKQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKAKEDIVTEQIDFSAARKQF 280 290 300 310 320 330 570 580 590 600 610 620 pF1KSD QLMENSRQAVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPRPPSVGGPPEDSGASAAKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLMENSRQAVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPRPPSVGGPPEDSGASAAKG 340 350 360 370 380 390 630 640 650 660 670 680 pF1KSD QKSPGALETPSAAGSQGNTASQGKEGPYSEPSKRGPLSKLWAEDGEFTSARAVLTVVKDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKSPGALETPSAAGSQGNTASQGKEGPYSEPSKRGPLSKLWAEDGEFTSARAVLTVVKDD 400 410 420 430 440 450 690 700 710 720 730 740 pF1KSD DHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETT 460 470 480 490 500 510 750 760 770 780 790 800 pF1KSD NALQENSLADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSPSSTLGDSPLVDDPLEYQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NALQENSLADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSPSSTLGDSPLVDDPLEYQA 520 530 540 550 560 570 810 820 830 840 850 860 pF1KSD GLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGPEATVEEAEAAAFGSEKPQSMFEPPQVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGPEATVEEAEAAAFGSEKPQSMFEPPQVS 580 590 600 610 620 630 870 880 890 900 910 920 pF1KSD SPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINMEETRPEGSYFSKYSEAAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINMEETRPEGSYFSKYSEAAEL 640 650 660 670 680 690 930 940 950 960 970 980 pF1KSD RSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVLQSTQSPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVLQSTQSPR 700 710 720 730 740 750 990 1000 1010 1020 1030 1040 pF1KSD TKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAPEEAAGTQRPKNLMQTLME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAPEEAAGTQRPKNLMQTLME 760 770 780 790 800 810 1050 1060 1070 1080 1090 1100 pF1KSD DYETHKSKRRERMDDSSYTSKLLSCKVTSEVLEATRVNRRKSALALRWEAGIYANQEEED ::::::::::::::::: :::::::::::::::::::::::::::::: NP_001 DYETHKSKRRERMDDSS-------------VLEATRVNRRKSALALRWEAGIYANQEEED 820 830 840 850 pF1KSD NE :: NP_001 NE >>NP_060204 (OMIM: 610182) palmdelphin [Homo sapiens] (551 aa) initn: 295 init1: 226 opt: 391 Z-score: 248.1 bits: 56.7 E(85289): 4.4e-07 Smith-Waterman score: 391; 28.2% identity (53.7% similar) in 404 aa overlap (1-385:1-387) 10 20 30 40 50 60 pF1KSD MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTA : :::: : :::::..::: : :: :: ...:. : :: :.:.:::::::.:: .: NP_060 MEEAELVKGRLQAITDKRKIQEEISQKRLKIEEDKLKHQHLKKKALREKWLLDGISSG-- 10 20 30 40 50 70 80 90 100 110 120 pF1KSD EEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKETEKSFK .:.: ..:...:. ... ::..: :::.::: ::. : :::.::. ::.::: :.. . NP_060 KEQEEMKKQNQQDQHQIQVLEQSILRLEKEIQDLEKAELQISTKEEAILKKLKSIERTTE 60 70 80 90 100 110 130 140 150 160 170 pF1KSD DFQKGFS----STDGDAVNYISSQLPDLP--ILCSRTAEP---SPGQDGTSRAAGVGWEN :. .. . .... : ...:::: . :: . .: .: : . : NP_060 DIIRSVKVEREERAEESIEDIYANIPDLPKSYIPSRLRKEINEEKEDDEQNRKALYAMEI 120 130 140 150 160 170 180 190 200 210 220 pF1KSD VLLKEGESASNATETSGPDMTIKKPPQLSEDDIW---LKSEGDNYSATLLEPAASSLSPD . :. ... ... .: : : ::. .: :. ... . : . . NP_060 KVEKDLKTGESTVLSSIP---------LPSDDFKGTGIKVYDDGQKSVYAVSSNHSAAYN 180 190 200 210 220 230 240 250 260 270 280 pF1KSD HKNMEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDN--DVAREIRY . : : : . .. : .. :. : : ..:.. . ..:. NP_060 GTDGLAPVEVEELLRQASERNSKSPTEYHEPVYANPFYRPTTPQRETVTPGPNFQERIKI 230 240 250 260 270 280 290 300 310 320 330 340 pF1KSD LDEVLEANCCDSAVDGTYNGTSSPEPGAVVLVGGLSPPVHEAT---QPEPTERTASRQAP . : . .: . . :: : . . .. . : : . : : .: ... NP_060 KTNGLGIGVNES-IHNMGNGLSEERGNNFNHISPIPPVPHPRSVIQQAEEKLHTPQKRLM 290 300 310 320 330 340 350 360 370 380 390 400 pF1KSD PHIELSNSSPDPMAEAERTNGHSPS-QPRDAL-GDSLQVPVSPSSTTSSRCSSRDGEFTL : :: : : . . : .::... : : . ::. NP_060 TPWEESNVMQDKDAPSPK-----PRLSPRETIFGKSEHQNSSPTCQEDEEDVRYNIVHSL 350 360 370 380 390 400 410 420 430 440 450 460 pF1KSD TTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQA NP_060 PPDINDTEPVTMIFMGYQQAEDSEEDKKFLTGYDGIIHAELVVIDDEEEEDEGEAEKPSY 410 420 430 440 450 460 >>XP_005259623 (OMIM: 608134) PREDICTED: paralemmin-1 is (386 aa) initn: 384 init1: 346 opt: 368 Z-score: 236.8 bits: 54.1 E(85289): 1.9e-06 Smith-Waterman score: 368; 32.6% identity (61.6% similar) in 258 aa overlap (2-250:5-255) 10 20 30 40 50 pF1KSD MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIPA ::. ..:::::::::::::.:::.::.::... ::: :::.:::.:::.: :. XP_005 MVLAAETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTPS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KSD GTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQ-ISAKEQI-----ILEK ...: .: ::: ..:: ... :::...:::.::..:: .: .:::. . XP_005 SASEGDEDLRRQMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPSPVRAP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KSD LKETEKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAGVGWEN : . . ..: . . . .... . :. ::.. :: . .:: . : XP_005 APSPAKEERKTEVVMNSQQTPVGTPKDKRVSNTPL---RTVDGSPMM----KAAMYSVEI 130 140 150 160 170 180 190 200 210 220 pF1KSD VLLKE---GESASNATETSGPDMTIKKPPQLSEDDIWLKSEGDNYSATLLEPAASSLSPD .. :. ::. .. : : . . .. ::. . :. . . ..: .:: . XP_005 TVEKDKVTGETRVLSSTTLLPRQPLPLGIKVYEDETKVVHAVDGTAENGIHPLSSSEVDE 180 190 200 210 220 230 230 240 250 260 270 280 pF1KSD HKNMEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLD . ::...: :. : . : XP_005 LIHKADEVTLSEAGSTAGAAETRGAVEGAARTTPSRREITGVQAQPGEATSGPPGIQPGQ 240 250 260 270 280 290 >>NP_002570 (OMIM: 608134) paralemmin-1 isoform 1 [Homo (387 aa) initn: 384 init1: 346 opt: 368 Z-score: 236.8 bits: 54.1 E(85289): 1.9e-06 Smith-Waterman score: 368; 32.6% identity (61.6% similar) in 258 aa overlap (2-250:6-256) 10 20 30 40 50 pF1KSD MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIP ::. ..:::::::::::::.:::.::.::... ::: :::.:::.:::.: : NP_002 MEVLAAETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KSD AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQ-ISAKEQI-----ILE ....: .: ::: ..:: ... :::...:::.::..:: .: .:::. . NP_002 SSASEGDEDLRRQMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPSPVRA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KSD KLKETEKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAGVGWE : . . ..: . . . .... . :. ::.. :: . .:: . : NP_002 PAPSPAKEERKTEVVMNSQQTPVGTPKDKRVSNTPL---RTVDGSPMM----KAAMYSVE 130 140 150 160 170 180 190 200 210 220 pF1KSD NVLLKE---GESASNATETSGPDMTIKKPPQLSEDDIWLKSEGDNYSATLLEPAASSLSP .. :. ::. .. : : . . .. ::. . :. . . ..: .:: NP_002 ITVEKDKVTGETRVLSSTTLLPRQPLPLGIKVYEDETKVVHAVDGTAENGIHPLSSSEVD 180 190 200 210 220 230 230 240 250 260 270 280 pF1KSD DHKNMEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYL . . ::...: :. : . : NP_002 ELIHKADEVTLSEAGSTAGAAETRGAVEGAARTTPSRREITGVQAQPGEATSGPPGIQPG 240 250 260 270 280 290 >>XP_005259622 (OMIM: 608134) PREDICTED: paralemmin-1 is (389 aa) initn: 384 init1: 346 opt: 368 Z-score: 236.7 bits: 54.1 E(85289): 1.9e-06 Smith-Waterman score: 368; 32.6% identity (61.6% similar) in 258 aa overlap (2-250:8-258) 10 20 30 40 50 pF1KSD MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQG ::. ..:::::::::::::.:::.::.::... ::: :::.:::.:::.: XP_005 MLPRVLAAETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEG 10 20 30 40 50 60 60 70 80 90 100 pF1KSD IPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQ-ISAKEQI-----I :....: .: ::: ..:: ... :::...:::.::..:: .: .:::. . XP_005 TPSSASEGDEDLRRQMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPSPV 70 80 90 100 110 120 110 120 130 140 150 160 pF1KSD LEKLKETEKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAGVG : . . ..: . . . .... . :. ::.. :: . .:: . XP_005 RAPAPSPAKEERKTEVVMNSQQTPVGTPKDKRVSNTPL---RTVDGSPMM----KAAMYS 130 140 150 160 170 170 180 190 200 210 220 pF1KSD WENVLLKE---GESASNATETSGPDMTIKKPPQLSEDDIWLKSEGDNYSATLLEPAASSL : .. :. ::. .. : : . . .. ::. . :. . . ..: .:: XP_005 VEITVEKDKVTGETRVLSSTTLLPRQPLPLGIKVYEDETKVVHAVDGTAENGIHPLSSSE 180 190 200 210 220 230 230 240 250 260 270 280 pF1KSD SPDHKNMEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIR . . ::...: :. : . : XP_005 VDELIHKADEVTLSEAGSTAGAAETRGAVEGAARTTPSRREITGVQAQPGEATSGPPGIQ 240 250 260 270 280 290 >>NP_001035224 (OMIM: 608134) paralemmin-1 isoform 2 [Ho (343 aa) initn: 384 init1: 346 opt: 351 Z-score: 227.5 bits: 52.2 E(85289): 6.2e-06 Smith-Waterman score: 374; 29.2% identity (59.4% similar) in 367 aa overlap (2-356:6-330) 10 20 30 40 50 pF1KSD MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQGIP ::. ..:::::::::::::.:::.::.::... ::: :::.:::.:::.: : NP_001 MEVLAAETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KSD AGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQ-ISAKEQI-----ILE ....: .: ::: ..:: ... :::...:::.::..:: .: .:::. . NP_001 SSASEGDEDLRRQMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPSPVRA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KSD KLKETEKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAGVGWE : . . ..: . . . .... . :. ::.. :: . .. .:. : NP_001 PAPSPAKEERKTEVVMNSQQTPVGTPKDKRVSNTPL---RTVDGSPMMKAVVHAVDGTAE 130 140 150 160 170 180 190 200 210 220 pF1KSD NVLLKEGESASNATETSGPDMTIKKPPQLSEDDIWLKSEGDNYSATLLEPA---ASSLSP : : ...:. : :.: :.. :. :.. .:. . : :. .: NP_001 N-----GIHPLSSSEV---DELIHK-----ADEVTLSEAGSTAGAAETRGAVEGAARTTP 180 190 200 210 220 230 240 250 260 270 280 pF1KSD DHKNMEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYL ... :.. .. . :: ... : .:. :: . .. ... :. .... : NP_001 SRR----EITGVQAQ--PGEATSGPPGIQPGQ--EPPVTMIFMGYQNVEDEAETKKVLGL 230 240 250 260 270 290 300 310 320 330 340 pF1KSD DEVLEANCCDSAVDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASR---QAPP .... :. ... ... :: .:: :..: ::: .::: :: : NP_001 QDTITAELV--VIE---DAAEPKEP---------APPNGSAAEP-PTE-AASREENQAGP 280 290 300 310 320 350 360 370 380 390 400 pF1KSD HIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVPVSPSSTTSSRCSSRDGEFTLTTL : ..:.:. . NP_001 --EATTSDPQDLDMKKHRCKCCSIM 330 340 >>XP_016882339 (OMIM: 608134) PREDICTED: paralemmin-1 is (345 aa) initn: 384 init1: 346 opt: 351 Z-score: 227.4 bits: 52.2 E(85289): 6.3e-06 Smith-Waterman score: 374; 29.2% identity (59.4% similar) in 367 aa overlap (2-356:8-332) 10 20 30 40 50 pF1KSD MAEAELHKERLQAIAEKRKRQTEIEGKRQQLDEQILLLQHSKSKVLREKWLLQG ::. ..:::::::::::::.:::.::.::... ::: :::.:::.:::.: XP_016 MLPRVLAAETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEG 10 20 30 40 50 60 60 70 80 90 100 pF1KSD IPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQ-ISAKEQI-----I :....: .: ::: ..:: ... :::...:::.::..:: .: .:::. . XP_016 TPSSASEGDEDLRRQMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPSPV 70 80 90 100 110 120 110 120 130 140 150 160 pF1KSD LEKLKETEKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAGVG : . . ..: . . . .... . :. ::.. :: . .. .:. XP_016 RAPAPSPAKEERKTEVVMNSQQTPVGTPKDKRVSNTPL---RTVDGSPMMKAVVHAVDGT 130 140 150 160 170 170 180 190 200 210 220 pF1KSD WENVLLKEGESASNATETSGPDMTIKKPPQLSEDDIWLKSEGDNYSATLLEPA---ASSL :: : ...:. : :.: :.. :. :.. .:. . : :. XP_016 AEN-----GIHPLSSSEV---DELIHK-----ADEVTLSEAGSTAGAAETRGAVEGAART 180 190 200 210 220 230 240 250 260 270 280 pF1KSD SPDHKNMEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIR .:... :.. .. . :: ... : .:. :: . .. ... :. .... XP_016 TPSRR----EITGVQAQ--PGEATSGPPGIQPGQ--EPPVTMIFMGYQNVEDEAETKKVL 230 240 250 260 270 290 300 310 320 330 340 pF1KSD YLDEVLEANCCDSAVDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASR---QA :.... :. ... ... :: .:: :..: ::: .::: :: XP_016 GLQDTITAELV--VIE---DAAEPKEP---------APPNGSAAEP-PTE-AASREENQA 280 290 300 310 320 350 360 370 380 390 400 pF1KSD PPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVPVSPSSTTSSRCSSRDGEFTLT : : ..:.:. . XP_016 GP--EATTSDPQDLDMKKHRCKCCSIM 330 340 1103 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 04:12:14 2016 done: Thu Nov 3 04:12:16 2016 Total Scan time: 14.250 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]