FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0924, 606 aa 1>>>pF1KSDA0924 606 - 606 aa - 606 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.3253+/-0.000445; mu= -5.6795+/- 0.028 mean_var=479.1832+/-97.860, 0's: 0 Z-trim(122.9): 1718 B-trim: 0 in 0/60 Lambda= 0.058590 statistics sampled from 39624 (41707) to 39624 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.774), E-opt: 0.2 (0.489), width: 16 Scan time: 12.440 The best scores are: opt bits E(85289) NP_055712 (OMIM: 613907) zinc finger protein 652 [ ( 606) 4206 370.2 1.1e-101 NP_001138837 (OMIM: 613907) zinc finger protein 65 ( 606) 4206 370.2 1.1e-101 XP_005257223 (OMIM: 613907) PREDICTED: zinc finger ( 426) 2261 205.6 2.7e-52 NP_001318063 (OMIM: 606954) zinc finger protein 25 ( 423) 732 76.4 2.2e-13 NP_001318062 (OMIM: 606954) zinc finger protein 25 ( 435) 732 76.4 2.2e-13 NP_066385 (OMIM: 606954) zinc finger protein 253 i ( 499) 732 76.5 2.5e-13 XP_005259469 (OMIM: 604749) PREDICTED: zinc finger ( 734) 733 76.7 3e-13 NP_004225 (OMIM: 604749) zinc finger protein 235 [ ( 738) 733 76.8 3e-13 XP_016881642 (OMIM: 604750) PREDICTED: zinc finger ( 502) 723 75.7 4.2e-13 XP_016881641 (OMIM: 604750) PREDICTED: zinc finger ( 502) 723 75.7 4.2e-13 XP_016881606 (OMIM: 603984) PREDICTED: zinc finger ( 486) 721 75.5 4.6e-13 XP_016881605 (OMIM: 603984) PREDICTED: zinc finger ( 504) 721 75.6 4.7e-13 NP_001152765 (OMIM: 603984) zinc finger protein 73 ( 536) 721 75.6 4.9e-13 XP_011525901 (OMIM: 603984) PREDICTED: zinc finger ( 550) 721 75.6 5e-13 XP_006722660 (OMIM: 603984) PREDICTED: zinc finger ( 550) 721 75.6 5e-13 XP_011525900 (OMIM: 603984) PREDICTED: zinc finger ( 551) 721 75.6 5e-13 XP_005259754 (OMIM: 603984) PREDICTED: zinc finger ( 551) 721 75.6 5e-13 XP_016881640 (OMIM: 604750) PREDICTED: zinc finger ( 669) 723 75.9 5e-13 XP_016881639 (OMIM: 604750) PREDICTED: zinc finger ( 688) 723 75.9 5.1e-13 XP_006723037 (OMIM: 604750) PREDICTED: zinc finger ( 700) 723 75.9 5.2e-13 XP_016881638 (OMIM: 604750) PREDICTED: zinc finger ( 700) 723 75.9 5.2e-13 NP_006621 (OMIM: 604750) zinc finger protein 234 [ ( 700) 723 75.9 5.2e-13 NP_001138296 (OMIM: 604750) zinc finger protein 23 ( 700) 723 75.9 5.2e-13 XP_016882723 (OMIM: 603899) PREDICTED: zinc finger ( 518) 715 75.1 6.8e-13 NP_001243102 (OMIM: 603899) zinc finger protein 85 ( 531) 715 75.1 6.9e-13 XP_011526566 (OMIM: 603899) PREDICTED: zinc finger ( 536) 715 75.1 7e-13 NP_003420 (OMIM: 603899) zinc finger protein 85 is ( 595) 715 75.1 7.5e-13 NP_001243100 (OMIM: 603899) zinc finger protein 85 ( 625) 715 75.2 7.7e-13 XP_011526565 (OMIM: 603899) PREDICTED: zinc finger ( 640) 715 75.2 7.8e-13 XP_016882717 (OMIM: 194554) PREDICTED: zinc finger ( 646) 714 75.1 8.4e-13 XP_016882719 (OMIM: 194554) PREDICTED: zinc finger ( 646) 714 75.1 8.4e-13 XP_016882718 (OMIM: 194554) PREDICTED: zinc finger ( 646) 714 75.1 8.4e-13 XP_016882706 (OMIM: 194554) PREDICTED: zinc finger ( 682) 714 75.1 8.7e-13 XP_016882716 (OMIM: 194554) PREDICTED: zinc finger ( 682) 714 75.1 8.7e-13 XP_016882715 (OMIM: 194554) PREDICTED: zinc finger ( 682) 714 75.1 8.7e-13 XP_011525569 (OMIM: 194554) PREDICTED: zinc finger ( 682) 714 75.1 8.7e-13 XP_016882707 (OMIM: 194554) PREDICTED: zinc finger ( 682) 714 75.1 8.7e-13 XP_016882713 (OMIM: 194554) PREDICTED: zinc finger ( 682) 714 75.1 8.7e-13 XP_016882710 (OMIM: 194554) PREDICTED: zinc finger ( 682) 714 75.1 8.7e-13 XP_011525571 (OMIM: 194554) PREDICTED: zinc finger ( 682) 714 75.1 8.7e-13 XP_011525575 (OMIM: 194554) PREDICTED: zinc finger ( 682) 714 75.1 8.7e-13 NP_003416 (OMIM: 194554) zinc finger protein 45 [H ( 682) 714 75.1 8.7e-13 XP_016882709 (OMIM: 194554) PREDICTED: zinc finger ( 682) 714 75.1 8.7e-13 XP_016882714 (OMIM: 194554) PREDICTED: zinc finger ( 682) 714 75.1 8.7e-13 XP_016882708 (OMIM: 194554) PREDICTED: zinc finger ( 682) 714 75.1 8.7e-13 XP_016882711 (OMIM: 194554) PREDICTED: zinc finger ( 682) 714 75.1 8.7e-13 XP_011525573 (OMIM: 194554) PREDICTED: zinc finger ( 682) 714 75.1 8.7e-13 XP_016882712 (OMIM: 194554) PREDICTED: zinc finger ( 682) 714 75.1 8.7e-13 NP_037512 (OMIM: 603994) zinc finger protein 112 i ( 907) 713 75.2 1.1e-12 NP_001076804 (OMIM: 603994) zinc finger protein 11 ( 913) 713 75.2 1.1e-12 >>NP_055712 (OMIM: 613907) zinc finger protein 652 [Homo (606 aa) initn: 4206 init1: 4206 opt: 4206 Z-score: 1946.4 bits: 370.2 E(85289): 1.1e-101 Smith-Waterman score: 4206; 100.0% identity (100.0% similar) in 606 aa overlap (1-606:1-606) 10 20 30 40 50 60 pF1KSD MSHTASSCQELVENCAVHVAGMAQEDSRRGQVPSSFYHGANQELDLSTKVYKRESGSPYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MSHTASSCQELVENCAVHVAGMAQEDSRRGQVPSSFYHGANQELDLSTKVYKRESGSPYS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD VLVDTKMSKPHLHETEEQPYFRETRAVSDVHAVKEDRENSDDTEEEEEEVSYKREQIIVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VLVDTKMSKPHLHETEEQPYFRETRAVSDVHAVKEDRENSDDTEEEEEEVSYKREQIIVE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD VNLNNQTLNVSKGEKGVSSQSKETPVLKTSSEEEEEESEEEATDDSNDYGENEKQKKKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VNLNNQTLNVSKGEKGVSSQSKETPVLKTSSEEEEEESEEEATDDSNDYGENEKQKKKEK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD IVEKVSVTQRRTRRAASVAAATTSPTPRTTRGRRKSVEPPKRKKRATKEPKAPVQKAKCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IVEKVSVTQRRTRRAASVAAATTSPTPRTTRGRRKSVEPPKRKKRATKEPKAPVQKAKCE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD EKETLTCEKCPRVFNTRWYLEKHMNVTHRRMQICDKCGKKFVLESELSLHQQTDCEKNIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EKETLTCEKCPRVFNTRWYLEKHMNVTHRRMQICDKCGKKFVLESELSLHQQTDCEKNIQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD CVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 CVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD DFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD SNMLKAHKEKCFRVTSPVNVPPAVQIPLTTSPATPVPSVVNTATTPTPPINMNPVSTLPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SNMLKAHKEKCFRVTSPVNVPPAVQIPLTTSPATPVPSVVNTATTPTPPINMNPVSTLPP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD RPIPHPFSHLHIHPHPHHPHHLPIPPVPHLPPPPALFKSEPLNHRGQSEDNFLRHLAEKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RPIPHPFSHLHIHPHPHHPHHLPIPPVPHLPPPPALFKSEPLNHRGQSEDNFLRHLAEKN 550 560 570 580 590 600 pF1KSD SSAQHH :::::: NP_055 SSAQHH >>NP_001138837 (OMIM: 613907) zinc finger protein 652 [H (606 aa) initn: 4206 init1: 4206 opt: 4206 Z-score: 1946.4 bits: 370.2 E(85289): 1.1e-101 Smith-Waterman score: 4206; 100.0% identity (100.0% similar) in 606 aa overlap (1-606:1-606) 10 20 30 40 50 60 pF1KSD MSHTASSCQELVENCAVHVAGMAQEDSRRGQVPSSFYHGANQELDLSTKVYKRESGSPYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSHTASSCQELVENCAVHVAGMAQEDSRRGQVPSSFYHGANQELDLSTKVYKRESGSPYS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD VLVDTKMSKPHLHETEEQPYFRETRAVSDVHAVKEDRENSDDTEEEEEEVSYKREQIIVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLVDTKMSKPHLHETEEQPYFRETRAVSDVHAVKEDRENSDDTEEEEEEVSYKREQIIVE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD VNLNNQTLNVSKGEKGVSSQSKETPVLKTSSEEEEEESEEEATDDSNDYGENEKQKKKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNLNNQTLNVSKGEKGVSSQSKETPVLKTSSEEEEEESEEEATDDSNDYGENEKQKKKEK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD IVEKVSVTQRRTRRAASVAAATTSPTPRTTRGRRKSVEPPKRKKRATKEPKAPVQKAKCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVEKVSVTQRRTRRAASVAAATTSPTPRTTRGRRKSVEPPKRKKRATKEPKAPVQKAKCE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD EKETLTCEKCPRVFNTRWYLEKHMNVTHRRMQICDKCGKKFVLESELSLHQQTDCEKNIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKETLTCEKCPRVFNTRWYLEKHMNVTHRRMQICDKCGKKFVLESELSLHQQTDCEKNIQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD CVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD TCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD DFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD SNMLKAHKEKCFRVTSPVNVPPAVQIPLTTSPATPVPSVVNTATTPTPPINMNPVSTLPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNMLKAHKEKCFRVTSPVNVPPAVQIPLTTSPATPVPSVVNTATTPTPPINMNPVSTLPP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD RPIPHPFSHLHIHPHPHHPHHLPIPPVPHLPPPPALFKSEPLNHRGQSEDNFLRHLAEKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPIPHPFSHLHIHPHPHHPHHLPIPPVPHLPPPPALFKSEPLNHRGQSEDNFLRHLAEKN 550 560 570 580 590 600 pF1KSD SSAQHH :::::: NP_001 SSAQHH >>XP_005257223 (OMIM: 613907) PREDICTED: zinc finger pro (426 aa) initn: 2256 init1: 2256 opt: 2261 Z-score: 1059.7 bits: 205.6 E(85289): 2.7e-52 Smith-Waterman score: 2663; 70.3% identity (70.3% similar) in 606 aa overlap (1-606:1-426) 10 20 30 40 50 60 pF1KSD MSHTASSCQELVENCAVHVAGMAQEDSRRGQVPSSFYHGANQELDLSTKVYKRESGSPYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSHTASSCQELVENCAVHVAGMAQEDSRRGQVPSSFYHGANQELDLSTKVYKRESGSPYS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD VLVDTKMSKPHLHETEEQPYFRETRAVSDVHAVKEDRENSDDTEEEEEEVSYKREQIIVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLVDTKMSKPHLHETEEQPYFRETRAVSDVHAVKEDRENSDDTEEEEEEVSYKREQIIVE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD VNLNNQTLNVSKGEKGVSSQSKETPVLKTSSEEEEEESEEEATDDSNDYGENEKQKKKEK XP_005 ------------------------------------------------------------ 190 200 210 220 230 240 pF1KSD IVEKVSVTQRRTRRAASVAAATTSPTPRTTRGRRKSVEPPKRKKRATKEPKAPVQKAKCE XP_005 ------------------------------------------------------------ 250 260 270 280 290 300 pF1KSD EKETLTCEKCPRVFNTRWYLEKHMNVTHRRMQICDKCGKKFVLESELSLHQQTDCEKNIQ XP_005 ------------------------------------------------------------ 310 320 330 340 350 360 pF1KSD CVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCE 130 140 150 160 170 180 370 380 390 400 410 420 pF1KSD TCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGK 190 200 210 220 230 240 430 440 450 460 470 480 pF1KSD DFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRF 250 260 270 280 290 300 490 500 510 520 530 540 pF1KSD SNMLKAHKEKCFRVTSPVNVPPAVQIPLTTSPATPVPSVVNTATTPTPPINMNPVSTLPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SNMLKAHKEKCFRVTSPVNVPPAVQIPLTTSPATPVPSVVNTATTPTPPINMNPVSTLPP 310 320 330 340 350 360 550 560 570 580 590 600 pF1KSD RPIPHPFSHLHIHPHPHHPHHLPIPPVPHLPPPPALFKSEPLNHRGQSEDNFLRHLAEKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RPIPHPFSHLHIHPHPHHPHHLPIPPVPHLPPPPALFKSEPLNHRGQSEDNFLRHLAEKN 370 380 390 400 410 420 pF1KSD SSAQHH :::::: XP_005 SSAQHH >>NP_001318063 (OMIM: 606954) zinc finger protein 253 is (423 aa) initn: 1600 init1: 579 opt: 732 Z-score: 361.3 bits: 76.4 E(85289): 2.2e-13 Smith-Waterman score: 732; 42.2% identity (64.8% similar) in 244 aa overlap (247-488:126-367) 220 230 240 250 260 270 pF1KSD VEPPKRKKRATKEPKAPVQKAKCEEKETLTCEKCPRVFNTRWYLEKHMNV-THRRMQICD ::.: ..:: : : . : .. :. NP_001 FKCIICGKAFKRSSTLTTHKKIHTGEKPYRCEECGKAFNQSANLTTHKRIHTGEKPYRCE 100 110 120 130 140 150 280 290 300 310 320 330 pF1KSD KCGKKFVLESELSLHQQTDC-EKNIQCVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEIC .::: : :.:. :.. :: .: :.:.:.. .: : :::: .:: ..:: : NP_001 ECGKAFKQSSNLTTHKKIHTGEKPYKCEECGKAFNRSTDLTTH-KIVHT-GEKPYKCEEC 160 170 180 190 200 210 340 350 360 370 380 390 pF1KSD EKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERF : : .:: : ::. :..:: ::::::. .: .:. :.::::..::.: . : NP_001 GKAFKHPSHVTTHKKIHTRGKPYNCEECGKSFKHCSNLTIHKRIHTGEKPYKCEECGKAF 220 230 240 250 260 270 400 410 420 430 440 450 pF1KSD QYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRP . . .: .: .: :.: . :. ::: :: . . : : ::::::. :. :::.:: NP_001 HLSSHLTTHKILHTGEKPYRCRECGKAFNHSTTLFSHEKIHTGEKPYKCDECGKTFTWPS 280 290 300 310 320 330 460 470 480 490 500 510 pF1KSD NMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKEKCFRVTSPVNVPPAVQIPLTTSPAT ...:.::::::::: :. ::. : :. : .:: NP_001 ILSKHKRTHTGEKPYKCEECGKSFTASSTLTTHKRIHTGEKPYKCEECGKAFNWSSDLNK 340 350 360 370 380 390 520 530 540 550 560 570 pF1KSD PVPSVVNTATTPTPPINMNPVSTLPPRPIPHPFSHLHIHPHPHHPHHLPIPPVPHLPPPP NP_001 HKKIHIERKPYIVKNVTDLLNVPPLLISIR 400 410 420 >>NP_001318062 (OMIM: 606954) zinc finger protein 253 is (435 aa) initn: 1600 init1: 579 opt: 732 Z-score: 361.1 bits: 76.4 E(85289): 2.2e-13 Smith-Waterman score: 732; 42.2% identity (64.8% similar) in 244 aa overlap (247-488:138-379) 220 230 240 250 260 270 pF1KSD VEPPKRKKRATKEPKAPVQKAKCEEKETLTCEKCPRVFNTRWYLEKHMNV-THRRMQICD ::.: ..:: : : . : .. :. NP_001 FKCIICGKAFKRSSTLTTHKKIHTGEKPYRCEECGKAFNQSANLTTHKRIHTGEKPYRCE 110 120 130 140 150 160 280 290 300 310 320 330 pF1KSD KCGKKFVLESELSLHQQTDC-EKNIQCVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEIC .::: : :.:. :.. :: .: :.:.:.. .: : :::: .:: ..:: : NP_001 ECGKAFKQSSNLTTHKKIHTGEKPYKCEECGKAFNRSTDLTTH-KIVHT-GEKPYKCEEC 170 180 190 200 210 220 340 350 360 370 380 390 pF1KSD EKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERF : : .:: : ::. :..:: ::::::. .: .:. :.::::..::.: . : NP_001 GKAFKHPSHVTTHKKIHTRGKPYNCEECGKSFKHCSNLTIHKRIHTGEKPYKCEECGKAF 230 240 250 260 270 280 400 410 420 430 440 450 pF1KSD QYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRP . . .: .: .: :.: . :. ::: :: . . : : ::::::. :. :::.:: NP_001 HLSSHLTTHKILHTGEKPYRCRECGKAFNHSTTLFSHEKIHTGEKPYKCDECGKTFTWPS 290 300 310 320 330 340 460 470 480 490 500 510 pF1KSD NMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKEKCFRVTSPVNVPPAVQIPLTTSPAT ...:.::::::::: :. ::. : :. : .:: NP_001 ILSKHKRTHTGEKPYKCEECGKSFTASSTLTTHKRIHTGEKPYKCEECGKAFNWSSDLNK 350 360 370 380 390 400 520 530 540 550 560 570 pF1KSD PVPSVVNTATTPTPPINMNPVSTLPPRPIPHPFSHLHIHPHPHHPHHLPIPPVPHLPPPP NP_001 HKKIHIERKPYIVKNVTDLLNVPPLLISIR 410 420 430 >>NP_066385 (OMIM: 606954) zinc finger protein 253 isofo (499 aa) initn: 1600 init1: 579 opt: 732 Z-score: 360.4 bits: 76.5 E(85289): 2.5e-13 Smith-Waterman score: 732; 42.2% identity (64.8% similar) in 244 aa overlap (247-488:202-443) 220 230 240 250 260 270 pF1KSD VEPPKRKKRATKEPKAPVQKAKCEEKETLTCEKCPRVFNTRWYLEKHMNV-THRRMQICD ::.: ..:: : : . : .. :. NP_066 FKCIICGKAFKRSSTLTTHKKIHTGEKPYRCEECGKAFNQSANLTTHKRIHTGEKPYRCE 180 190 200 210 220 230 280 290 300 310 320 330 pF1KSD KCGKKFVLESELSLHQQTDC-EKNIQCVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEIC .::: : :.:. :.. :: .: :.:.:.. .: : :::: .:: ..:: : NP_066 ECGKAFKQSSNLTTHKKIHTGEKPYKCEECGKAFNRSTDLTTH-KIVHT-GEKPYKCEEC 240 250 260 270 280 340 350 360 370 380 390 pF1KSD EKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERF : : .:: : ::. :..:: ::::::. .: .:. :.::::..::.: . : NP_066 GKAFKHPSHVTTHKKIHTRGKPYNCEECGKSFKHCSNLTIHKRIHTGEKPYKCEECGKAF 290 300 310 320 330 340 400 410 420 430 440 450 pF1KSD QYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRP . . .: .: .: :.: . :. ::: :: . . : : ::::::. :. :::.:: NP_066 HLSSHLTTHKILHTGEKPYRCRECGKAFNHSTTLFSHEKIHTGEKPYKCDECGKTFTWPS 350 360 370 380 390 400 460 470 480 490 500 510 pF1KSD NMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKEKCFRVTSPVNVPPAVQIPLTTSPAT ...:.::::::::: :. ::. : :. : .:: NP_066 ILSKHKRTHTGEKPYKCEECGKSFTASSTLTTHKRIHTGEKPYKCEECGKAFNWSSDLNK 410 420 430 440 450 460 520 530 540 550 560 570 pF1KSD PVPSVVNTATTPTPPINMNPVSTLPPRPIPHPFSHLHIHPHPHHPHHLPIPPVPHLPPPP NP_066 HKKIHIERKPYIVKNVTDLLNVPPLLISIR 470 480 490 >>XP_005259469 (OMIM: 604749) PREDICTED: zinc finger pro (734 aa) initn: 1606 init1: 573 opt: 733 Z-score: 358.9 bits: 76.7 E(85289): 3e-13 Smith-Waterman score: 746; 31.4% identity (63.8% similar) in 389 aa overlap (103-488:217-586) 80 90 100 110 120 130 pF1KSD HETEEQPYFRETRAVSDVHAVKEDRENSDDTEEEEEEVSYKREQIIVEVNLNNQTLNVSK ........ .::... . . ...::.:: XP_005 TQNYQRSCKQTQMKNKLCIFAPYVDIFSCISHHHDDNIVHKRDKVHSNSDCGKDTLKVSP 190 200 210 220 230 240 140 150 160 170 180 190 pF1KSD GEKGVSSQSKETPVLKTSSEEEEEESEEEATDDSNDYGENEKQKKKEKIVEKVSVTQRRT ....: ..:... . . ::: .::.. : .:: . : :. .. : XP_005 ----LTQRS-----IHTGQKTYQGNECEEAFNDSSSL-ELHKQVHLGKKSPACSTHEKDT 250 260 270 280 290 200 210 220 230 240 250 pF1KSD RRAASVAAATTSPTPRTTR-GRRKSVEPPKRKKRATKEPKAPVQKAKCEEKETLTCEKCP .... :. ...: :... : . . :... :: ::..: XP_005 SYSSGI------PVQQSVRTGKKRYWCHECGKGFSQSSNLQTHQRVHTGEKP-YTCHECG 300 310 320 330 340 260 270 280 290 300 pF1KSD RVFNTRWYLEKHMNV-THRRMQICDKCGKKFVLESELSLHQQTDC-EKNIQCVSCNKSFK . :: .: :. . : .. ::.::: : ..:..: .. :: .: :.:.: XP_005 KSFNQSSHLYAHLPIHTGEKPYRCDSCGKGFSRSTDLNIHCRVHTGEKPYKCEVCGKGFT 350 360 370 380 390 400 310 320 330 340 350 360 pF1KSD KLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRS . :. : .: : :: ..: : :.: .... :. .::.. :. :. ::: :. : XP_005 QRSHLQAHERIHTG--EKPYKCGDCGKRFSCSSNLHTHQRVHTEEKPYKCDECGKCFSLS 410 420 430 440 450 460 370 380 390 400 410 420 pF1KSD MSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFD ..:. :. :.::::..::.: . :. ...::. .: :.: : :. ::: :....::. XP_005 FNLHSHQRVHTGEKPYKCEECGKGFSSASSFQSHQRVHTGEKPFRCNVCGKGFSQSSYFQ 470 480 490 500 510 520 430 440 450 460 470 480 pF1KSD EHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKE :...::::::. ::.::: :. :.. :.:.::::::: :. ::. : .. :.::. XP_005 AHQRVHTGEKPYKCEVCGKRFNWSLNLHNHQRVHTGEKPYKCEECGKGFSQASNLQAHQS 530 540 550 560 570 580 490 500 510 520 530 540 pF1KSD KCFRVTSPVNVPPAVQIPLTTSPATPVPSVVNTATTPTPPINMNPVSTLPPRPIPHPFSH XP_005 VHTGEKPFKCDACQKRFSQASHLQAHQRVHTGEKPYKCDTCGKAFSQRSNLQVHQIIHTG 590 600 610 620 630 640 >-- initn: 1027 init1: 533 opt: 534 Z-score: 268.0 bits: 59.9 E(85289): 3.5e-08 Smith-Waterman score: 534; 42.8% identity (77.9% similar) in 145 aa overlap (321-465:588-731) 300 310 320 330 340 350 pF1KSD QQTDCEKNIQCVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVA :: .:: :.:. :.:.: .:.. :. . XP_005 QRVHTGEKPYKCEECGKGFSQASNLQAHQSVHT-GEKPFKCDACQKRFSQASHLQAHQRV 560 570 580 590 600 610 360 370 380 390 400 410 pF1KSD HTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGH :: . :. :.::::.:.. .:.::.. :.:::::.::.: ..:... : .:. .: :. XP_005 HTGEKPYKCDTCGKAFSQRSNLQVHQIIHTGEKPFKCEECGKEFSWSAGLSAHQRVHTGE 620 630 640 650 660 670 420 430 440 450 460 470 pF1KSD KQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYP : . :: ::: :.. ..: :...::::.:.::..: :.:..: .. :.:.::: XP_005 KPYTCQQCGKGFSQASHFHTHQRVHTGERPYICDVCCKGFSQRSHLIYHQRVHTGGNL 680 690 700 710 720 730 480 490 500 510 520 530 pF1KSD CDVCGQRFRFSNMLKAHKEKCFRVTSPVNVPPAVQIPLTTSPATPVPSVVNTATTPTPPI >>NP_004225 (OMIM: 604749) zinc finger protein 235 [Homo (738 aa) initn: 1606 init1: 573 opt: 733 Z-score: 358.9 bits: 76.8 E(85289): 3e-13 Smith-Waterman score: 746; 31.4% identity (63.8% similar) in 389 aa overlap (103-488:221-590) 80 90 100 110 120 130 pF1KSD HETEEQPYFRETRAVSDVHAVKEDRENSDDTEEEEEEVSYKREQIIVEVNLNNQTLNVSK ........ .::... . . ...::.:: NP_004 TQNYQRSCKQTQMKNKLCIFAPYVDIFSCISHHHDDNIVHKRDKVHSNSDCGKDTLKVSP 200 210 220 230 240 250 140 150 160 170 180 190 pF1KSD GEKGVSSQSKETPVLKTSSEEEEEESEEEATDDSNDYGENEKQKKKEKIVEKVSVTQRRT ....: ..:... . . ::: .::.. : .:: . : :. .. : NP_004 ----LTQRS-----IHTGQKTYQGNECEEAFNDSSSL-ELHKQVHLGKKSPACSTHEKDT 260 270 280 290 300 200 210 220 230 240 250 pF1KSD RRAASVAAATTSPTPRTTR-GRRKSVEPPKRKKRATKEPKAPVQKAKCEEKETLTCEKCP .... :. ...: :... : . . :... :: ::..: NP_004 SYSSGI------PVQQSVRTGKKRYWCHECGKGFSQSSNLQTHQRVHTGEKP-YTCHECG 310 320 330 340 350 260 270 280 290 300 pF1KSD RVFNTRWYLEKHMNV-THRRMQICDKCGKKFVLESELSLHQQTDC-EKNIQCVSCNKSFK . :: .: :. . : .. ::.::: : ..:..: .. :: .: :.:.: NP_004 KSFNQSSHLYAHLPIHTGEKPYRCDSCGKGFSRSTDLNIHCRVHTGEKPYKCEVCGKGFT 360 370 380 390 400 410 310 320 330 340 350 360 pF1KSD KLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRS . :. : .: : :: ..: : :.: .... :. .::.. :. :. ::: :. : NP_004 QRSHLQAHERIHTG--EKPYKCGDCGKRFSCSSNLHTHQRVHTEEKPYKCDECGKCFSLS 420 430 440 450 460 470 370 380 390 400 410 420 pF1KSD MSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFD ..:. :. :.::::..::.: . :. ...::. .: :.: : :. ::: :....::. NP_004 FNLHSHQRVHTGEKPYKCEECGKGFSSASSFQSHQRVHTGEKPFRCNVCGKGFSQSSYFQ 480 490 500 510 520 530 430 440 450 460 470 480 pF1KSD EHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKE :...::::::. ::.::: :. :.. :.:.::::::: :. ::. : .. :.::. NP_004 AHQRVHTGEKPYKCEVCGKRFNWSLNLHNHQRVHTGEKPYKCEECGKGFSQASNLQAHQS 540 550 560 570 580 590 490 500 510 520 530 540 pF1KSD KCFRVTSPVNVPPAVQIPLTTSPATPVPSVVNTATTPTPPINMNPVSTLPPRPIPHPFSH NP_004 VHTGEKPFKCDACQKRFSQASHLQAHQRVHTGEKPYKCDTCGKAFSQRSNLQVHQIIHTG 600 610 620 630 640 650 >-- initn: 1027 init1: 533 opt: 534 Z-score: 267.9 bits: 59.9 E(85289): 3.5e-08 Smith-Waterman score: 534; 42.8% identity (77.9% similar) in 145 aa overlap (321-465:592-735) 300 310 320 330 340 350 pF1KSD QQTDCEKNIQCVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVA :: .:: :.:. :.:.: .:.. :. . NP_004 QRVHTGEKPYKCEECGKGFSQASNLQAHQSVHT-GEKPFKCDACQKRFSQASHLQAHQRV 570 580 590 600 610 620 360 370 380 390 400 410 pF1KSD HTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGH :: . :. :.::::.:.. .:.::.. :.:::::.::.: ..:... : .:. .: :. NP_004 HTGEKPYKCDTCGKAFSQRSNLQVHQIIHTGEKPFKCEECGKEFSWSAGLSAHQRVHTGE 630 640 650 660 670 680 420 430 440 450 460 470 pF1KSD KQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYP : . :: ::: :.. ..: :...::::.:.::..: :.:..: .. :.:.::: NP_004 KPYTCQQCGKGFSQASHFHTHQRVHTGERPYICDVCCKGFSQRSHLIYHQRVHTGGNL 690 700 710 720 730 480 490 500 510 520 530 pF1KSD CDVCGQRFRFSNMLKAHKEKCFRVTSPVNVPPAVQIPLTTSPATPVPSVVNTATTPTPPI >>XP_016881642 (OMIM: 604750) PREDICTED: zinc finger pro (502 aa) initn: 2677 init1: 582 opt: 723 Z-score: 356.3 bits: 75.7 E(85289): 4.2e-13 Smith-Waterman score: 723; 37.5% identity (66.4% similar) in 256 aa overlap (235-488:137-389) 210 220 230 240 250 260 pF1KSD PTPRTTRGRRKSVEPPKRKKRATKEPKAPVQKAKCEEKETLTCEKCPRVFNTRWYLEKHM :... :: ::.: . : .. : XP_016 NHCMVHTGEKPYKCEDCGKCFTCSSNLRIHQRVHTGEKP-YKCEECGKCFIQPSQFQAHR 110 120 130 140 150 160 270 280 290 300 310 320 pF1KSD NV-THRRMQICDKCGKKFVLESELSLHQQTDC-EKNIQCVSCNKSFKKLWSLHEHIKIVH . : .. .: ::: :. : .. :: . :: .: :.:::. ..: ....: XP_016 RIHTGEKPYVCKVCGKGFIYSSSFQAHQGVHTGEKPYKCNECGKSFR--MKIHYQVHLVV 170 180 190 200 210 220 330 340 350 360 370 380 pF1KSD GYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGE .:: ..::.: : : .... :. ::. . :: :: ::..:..: :..:.: :.:: XP_016 HTGEKPYKCEVCGKAFRQSSYLKIHLKAHSVQKPFKCEECGQGFNQSSRLQIHQLIHTGE 230 240 250 260 270 280 390 400 410 420 430 440 pF1KSD KPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFI ::..::.: . :. . .:. : :: :.: . :. ::: :.. ... :...:.::::: XP_016 KPYKCEECGKGFSRRADLKIHCRIHTGEKPYNCEECGKVFSQASHLLTHQRVHSGEKPFK 290 300 310 320 330 340 450 460 470 480 490 500 pF1KSD CEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKEKCFRVTSPVNVPP :: :::::. ... :...::::::: : ::. :..: : :. XP_016 CEECGKSFSRSAHLQAHQKVHTGEKPYKCGECGKGFKWSLNLDMHQRVHTGEKPYTCGEC 350 360 370 380 390 400 510 520 530 540 550 560 pF1KSD AVQIPLTTSPATPVPSVVNTATTPTPPINMNPVSTLPPRPIPHPFSHLHIHPHPHHPHHL XP_016 GKHFSQASSLQLHQSVHTGEKPYKCDVCGKVFSRSSQLQYHRRVHTGEKPYKCEICGKRF 410 420 430 440 450 460 >-- initn: 1213 init1: 462 opt: 462 Z-score: 237.1 bits: 53.7 E(85289): 1.8e-06 Smith-Waterman score: 462; 44.0% identity (68.7% similar) in 134 aa overlap (326-459:3-136) 300 310 320 330 340 350 pF1KSD EKNIQCVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDM :: ..:..: :.: .:.. :. .:: . XP_016 MGEKCYKCDVCGKEFSQSSHLQTHQRVHTVEK 10 20 30 360 370 380 390 400 410 pF1KSD PFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMC :: : :::.:.: .: :: ::::::. ::.: . : . .:. :. :: :.: : : XP_016 PFKCVECGKGFSRRSTLTVHCKLHSGEKPYNCEECGRAFIHASHLQEHQRIHTGEKPFKC 40 50 60 70 80 90 420 430 440 450 460 470 pF1KSD QWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCG . :::.: .. ...: .::::::. :: ::: :: :.. : XP_016 DTCGKNFRRRSALNNHCMVHTGEKPYKCEDCGKCFTCSSNLRIHQRVHTGEKPYKCEECG 100 110 120 130 140 150 480 490 500 510 520 530 pF1KSD QRFRFSNMLKAHKEKCFRVTSPVNVPPAVQIPLTTSPATPVPSVVNTATTPTPPINMNPV XP_016 KCFIQPSQFQAHRRIHTGEKPYVCKVCGKGFIYSSSFQAHQGVHTGEKPYKCNECGKSFR 160 170 180 190 200 210 >>XP_016881641 (OMIM: 604750) PREDICTED: zinc finger pro (502 aa) initn: 2677 init1: 582 opt: 723 Z-score: 356.3 bits: 75.7 E(85289): 4.2e-13 Smith-Waterman score: 723; 37.5% identity (66.4% similar) in 256 aa overlap (235-488:137-389) 210 220 230 240 250 260 pF1KSD PTPRTTRGRRKSVEPPKRKKRATKEPKAPVQKAKCEEKETLTCEKCPRVFNTRWYLEKHM :... :: ::.: . : .. : XP_016 NHCMVHTGEKPYKCEDCGKCFTCSSNLRIHQRVHTGEKP-YKCEECGKCFIQPSQFQAHR 110 120 130 140 150 160 270 280 290 300 310 320 pF1KSD NV-THRRMQICDKCGKKFVLESELSLHQQTDC-EKNIQCVSCNKSFKKLWSLHEHIKIVH . : .. .: ::: :. : .. :: . :: .: :.:::. ..: ....: XP_016 RIHTGEKPYVCKVCGKGFIYSSSFQAHQGVHTGEKPYKCNECGKSFR--MKIHYQVHLVV 170 180 190 200 210 220 330 340 350 360 370 380 pF1KSD GYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGE .:: ..::.: : : .... :. ::. . :: :: ::..:..: :..:.: :.:: XP_016 HTGEKPYKCEVCGKAFRQSSYLKIHLKAHSVQKPFKCEECGQGFNQSSRLQIHQLIHTGE 230 240 250 260 270 280 390 400 410 420 430 440 pF1KSD KPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFI ::..::.: . :. . .:. : :: :.: . :. ::: :.. ... :...:.::::: XP_016 KPYKCEECGKGFSRRADLKIHCRIHTGEKPYNCEECGKVFSQASHLLTHQRVHSGEKPFK 290 300 310 320 330 340 450 460 470 480 490 500 pF1KSD CEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKEKCFRVTSPVNVPP :: :::::. ... :...::::::: : ::. :..: : :. XP_016 CEECGKSFSRSAHLQAHQKVHTGEKPYKCGECGKGFKWSLNLDMHQRVHTGEKPYTCGEC 350 360 370 380 390 400 510 520 530 540 550 560 pF1KSD AVQIPLTTSPATPVPSVVNTATTPTPPINMNPVSTLPPRPIPHPFSHLHIHPHPHHPHHL XP_016 GKHFSQASSLQLHQSVHTGEKPYKCDVCGKVFSRSSQLQYHRRVHTGEKPYKCEICGKRF 410 420 430 440 450 460 >-- initn: 1213 init1: 462 opt: 462 Z-score: 237.1 bits: 53.7 E(85289): 1.8e-06 Smith-Waterman score: 462; 44.0% identity (68.7% similar) in 134 aa overlap (326-459:3-136) 300 310 320 330 340 350 pF1KSD EKNIQCVSCNKSFKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDM :: ..:..: :.: .:.. :. .:: . XP_016 MGEKCYKCDVCGKEFSQSSHLQTHQRVHTVEK 10 20 30 360 370 380 390 400 410 pF1KSD PFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMC :: : :::.:.: .: :: ::::::. ::.: . : . .:. :. :: :.: : : XP_016 PFKCVECGKGFSRRSTLTVHCKLHSGEKPYNCEECGRAFIHASHLQEHQRIHTGEKPFKC 40 50 60 70 80 90 420 430 440 450 460 470 pF1KSD QWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCG . :::.: .. ...: .::::::. :: ::: :: :.. : XP_016 DTCGKNFRRRSALNNHCMVHTGEKPYKCEDCGKCFTCSSNLRIHQRVHTGEKPYKCEECG 100 110 120 130 140 150 480 490 500 510 520 530 pF1KSD QRFRFSNMLKAHKEKCFRVTSPVNVPPAVQIPLTTSPATPVPSVVNTATTPTPPINMNPV XP_016 KCFIQPSQFQAHRRIHTGEKPYVCKVCGKGFIYSSSFQAHQGVHTGEKPYKCNECGKSFR 160 170 180 190 200 210 606 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 04:14:42 2016 done: Thu Nov 3 04:14:44 2016 Total Scan time: 12.440 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]