FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0957, 692 aa 1>>>pF1KSDA0957 692 - 692 aa - 692 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.2275+/-0.000998; mu= 7.5705+/- 0.060 mean_var=197.8406+/-40.023, 0's: 0 Z-trim(111.9): 217 B-trim: 0 in 0/52 Lambda= 0.091184 statistics sampled from 12535 (12773) to 12535 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.722), E-opt: 0.2 (0.392), width: 16 Scan time: 4.250 The best scores are: opt bits E(32554) CCDS56442.1 ANKRD6 gene_id:22881|Hs108|chr6 ( 692) 4525 608.2 1.2e-173 CCDS56441.1 ANKRD6 gene_id:22881|Hs108|chr6 ( 727) 3229 437.8 2.7e-122 CCDS56443.1 ANKRD6 gene_id:22881|Hs108|chr6 ( 663) 2793 380.4 4.7e-105 CCDS47460.1 ANKRD6 gene_id:22881|Hs108|chr6 ( 722) 1746 242.7 1.4e-63 CCDS6121.1 ANK1 gene_id:286|Hs108|chr8 (1880) 456 73.3 3.6e-12 CCDS6119.1 ANK1 gene_id:286|Hs108|chr8 (1881) 456 73.3 3.6e-12 CCDS47849.1 ANK1 gene_id:286|Hs108|chr8 (1897) 456 73.3 3.6e-12 CCDS54796.1 ANK2 gene_id:287|Hs108|chr4 (1863) 454 73.1 4.3e-12 CCDS7050.2 EHMT1 gene_id:79813|Hs108|chr9 (1298) 451 72.5 4.3e-12 CCDS43261.1 ANK2 gene_id:287|Hs108|chr4 (1872) 454 73.1 4.3e-12 CCDS3702.1 ANK2 gene_id:287|Hs108|chr4 (3957) 454 73.3 7.5e-12 CCDS42650.1 KIDINS220 gene_id:57498|Hs108|chr2 (1771) 447 72.1 7.8e-12 CCDS10197.2 ANKDD1A gene_id:348094|Hs108|chr15 ( 522) 436 70.2 8.5e-12 CCDS43842.1 DAPK1 gene_id:1612|Hs108|chr9 (1430) 439 71.0 1.4e-11 CCDS55712.1 ANK3 gene_id:288|Hs108|chr10 (1861) 429 69.8 4.2e-11 CCDS55711.1 ANK3 gene_id:288|Hs108|chr10 (1868) 429 69.8 4.2e-11 CCDS7258.1 ANK3 gene_id:288|Hs108|chr10 (4377) 429 70.1 7.9e-11 >>CCDS56442.1 ANKRD6 gene_id:22881|Hs108|chr6 (692 aa) initn: 4525 init1: 4525 opt: 4525 Z-score: 3230.7 bits: 608.2 E(32554): 1.2e-173 Smith-Waterman score: 4525; 99.9% identity (100.0% similar) in 692 aa overlap (1-692:1-692) 10 20 30 40 50 60 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 SQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD QTPLETARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QTPLETARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 DRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD LYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD HQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 HQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KLSGDSRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 KLSGDSRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD QELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD PAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 PAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQAN 610 620 630 640 650 660 670 680 690 pF1KSD QKAQQDKATLKEHIKSLEEELAKLRTRVQKEN :::::::::::::::::::::::::::::::: CCDS56 QKAQQDKATLKEHIKSLEEELAKLRTRVQKEN 670 680 690 >>CCDS56441.1 ANKRD6 gene_id:22881|Hs108|chr6 (727 aa) initn: 2842 init1: 2842 opt: 3229 Z-score: 2309.0 bits: 437.8 E(32554): 2.7e-122 Smith-Waterman score: 4426; 95.0% identity (95.2% similar) in 724 aa overlap (4-692:4-727) 10 20 30 40 50 60 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 SQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG 190 200 210 220 230 240 250 260 pF1KSD QTPLETARYHNNPEVALLLTKAPQ-----------------------------------G :::::::::::::::::::::::: : CCDS56 QTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKG 250 260 270 280 290 300 270 280 290 300 310 320 pF1KSD SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG 310 320 330 340 350 360 330 340 350 360 370 380 pF1KSD HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK 370 380 390 400 410 420 390 400 410 420 430 440 pF1KSD LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL 430 440 450 460 470 480 450 460 470 480 490 500 pF1KSD QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVD 490 500 510 520 530 540 510 520 530 540 550 560 pF1KSD QLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 QLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPM 550 560 570 580 590 600 570 580 590 600 610 620 pF1KSD NEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 NEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRD 610 620 630 640 650 660 630 640 650 660 670 680 pF1KSD TSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 TSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLR 670 680 690 700 710 720 690 pF1KSD TRVQKEN ::::::: CCDS56 TRVQKEN >>CCDS56443.1 ANKRD6 gene_id:22881|Hs108|chr6 (663 aa) initn: 2492 init1: 1591 opt: 2793 Z-score: 1999.6 bits: 380.4 E(32554): 4.7e-105 Smith-Waterman score: 3980; 90.2% identity (91.3% similar) in 702 aa overlap (1-692:1-663) 10 20 30 40 50 60 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF :::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDK-------------- 70 80 90 100 130 140 150 160 170 180 pF1KSD SQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV ::::::::::::::::::::::::::::::::::::::::: CCDS56 -------------------AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV 110 120 130 140 190 200 210 220 230 pF1KSD AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNA- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. CCDS56 AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNVL 150 160 170 180 190 200 240 250 260 270 280 290 pF1KSD ----GQTPLETARYHNNPE-----VALLLTKAPQGSVSAGDTPSSEQAVARKEEAREEFL :.. :. : . . : : . .:::::::::::::::::::::::::: CCDS56 RFSRGRS-LRKKRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREEFL 210 220 230 240 250 260 300 310 320 330 340 350 pF1KSD SASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 SASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPP 270 280 290 300 310 320 360 370 380 390 400 410 pF1KSD HEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 HEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNT 330 340 350 360 370 380 420 430 440 450 460 470 pF1KSD KLGQMENKTQHQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 KLGQMENKTQHQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTW 390 400 410 420 430 440 480 490 500 510 520 530 pF1KSD CMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRPKEKA :::::::::::::::::::::::::::: ::::::::::::::::::::::::::: CCDS56 CMLKIQNLEQKLSGDSRACRAKSTPSTC-----VDQLVVTAGPAAASDSSPPVVRPKEKA 450 460 470 480 490 500 540 550 560 570 580 590 pF1KSD LNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGK 510 520 530 540 550 560 600 610 620 630 640 650 pF1KSD SGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 SGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYER 570 580 590 600 610 620 660 670 680 690 pF1KSD KIEEARSQANQKAQQDKATLKEHIKSLEEELAKLRTRVQKEN :::::::::::::::::::::::::::::::::::::::::: CCDS56 KIEEARSQANQKAQQDKATLKEHIKSLEEELAKLRTRVQKEN 630 640 650 660 >>CCDS47460.1 ANKRD6 gene_id:22881|Hs108|chr6 (722 aa) initn: 2900 init1: 1685 opt: 1746 Z-score: 1254.7 bits: 242.7 E(32554): 1.4e-63 Smith-Waterman score: 4396; 94.4% identity (94.5% similar) in 727 aa overlap (1-692:1-722) 10 20 30 40 50 60 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 SQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG 190 200 210 220 230 240 250 260 pF1KSD QTPLETARYHNNPEVALLLTKAPQ-----------------------------------G :::::::::::::::::::::::: : CCDS47 QTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKG 250 260 270 280 290 300 270 280 290 300 310 320 pF1KSD SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG 310 320 330 340 350 360 330 340 350 360 370 380 pF1KSD HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK 370 380 390 400 410 420 390 400 410 420 430 440 pF1KSD LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL 430 440 450 460 470 480 450 460 470 480 490 500 pF1KSD QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVD ::::::::::::::::::::::::::::::::::::::::::::::::::::: :: CCDS47 QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTC-----VD 490 500 510 520 530 510 520 530 540 550 560 pF1KSD QLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 QLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPM 540 550 560 570 580 590 570 580 590 600 610 620 pF1KSD NEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 NEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRD 600 610 620 630 640 650 630 640 650 660 670 680 pF1KSD TSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 TSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLR 660 670 680 690 700 710 690 pF1KSD TRVQKEN ::::::: CCDS47 TRVQKEN 720 >>CCDS6121.1 ANK1 gene_id:286|Hs108|chr8 (1880 aa) initn: 701 init1: 421 opt: 456 Z-score: 332.0 bits: 73.3 E(32554): 3.6e-12 Smith-Waterman score: 456; 34.8% identity (64.4% similar) in 264 aa overlap (14-273:342-605) 10 20 30 40 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTK-HG : :::. :. . . :..:::. .: CCDS61 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 320 330 340 350 360 370 50 60 70 80 90 100 pF1KSD RTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALD ::::.: .:.:. :...:::.: ..:. .. : :: :. .:. :. :...: . . CCDS61 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 380 390 400 410 420 430 110 120 130 140 150 160 pF1KSD RQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLL .. .: :: :. : .. :: :.. :.: :: : .: :: : . .:.. ...:: CCDS61 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 440 450 460 470 480 490 170 180 190 200 210 220 pF1KSD AGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKV .. .: ..:: : ::.::: .:. . :: : .. : : ::::: .. .: CCDS61 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 500 510 520 530 540 550 230 240 250 260 270 pF1KSD AKILLEAGADTTIVNNAGQTPLETARYHNNPEVA-LLLTK--APQGSVSAGDTPSSEQAV :..::: : . ... : :::..: .::: ... ::: . .:.. . : :: CCDS61 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 560 570 580 590 600 610 280 290 300 310 320 330 pF1KSD ARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKR CCDS61 QNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 620 630 640 650 660 670 >>CCDS6119.1 ANK1 gene_id:286|Hs108|chr8 (1881 aa) initn: 701 init1: 421 opt: 456 Z-score: 332.0 bits: 73.3 E(32554): 3.6e-12 Smith-Waterman score: 456; 34.8% identity (64.4% similar) in 264 aa overlap (14-273:342-605) 10 20 30 40 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTK-HG : :::. :. . . :..:::. .: CCDS61 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 320 330 340 350 360 370 50 60 70 80 90 100 pF1KSD RTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALD ::::.: .:.:. :...:::.: ..:. .. : :: :. .:. :. :...: . . CCDS61 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 380 390 400 410 420 430 110 120 130 140 150 160 pF1KSD RQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLL .. .: :: :. : .. :: :.. :.: :: : .: :: : . .:.. ...:: CCDS61 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 440 450 460 470 480 490 170 180 190 200 210 220 pF1KSD AGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKV .. .: ..:: : ::.::: .:. . :: : .. : : ::::: .. .: CCDS61 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 500 510 520 530 540 550 230 240 250 260 270 pF1KSD AKILLEAGADTTIVNNAGQTPLETARYHNNPEVA-LLLTK--APQGSVSAGDTPSSEQAV :..::: : . ... : :::..: .::: ... ::: . .:.. . : :: CCDS61 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 560 570 580 590 600 610 280 290 300 310 320 330 pF1KSD ARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKR CCDS61 QNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 620 630 640 650 660 670 >>CCDS47849.1 ANK1 gene_id:286|Hs108|chr8 (1897 aa) initn: 701 init1: 421 opt: 456 Z-score: 332.0 bits: 73.3 E(32554): 3.6e-12 Smith-Waterman score: 456; 34.8% identity (64.4% similar) in 264 aa overlap (14-273:375-638) 10 20 30 40 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTK-HG : :::. :. . . :..:::. .: CCDS47 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 350 360 370 380 390 400 50 60 70 80 90 100 pF1KSD RTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALD ::::.: .:.:. :...:::.: ..:. .. : :: :. .:. :. :...: . . CCDS47 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 410 420 430 440 450 460 110 120 130 140 150 160 pF1KSD RQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLL .. .: :: :. : .. :: :.. :.: :: : .: :: : . .:.. ...:: CCDS47 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 470 480 490 500 510 520 170 180 190 200 210 220 pF1KSD AGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKV .. .: ..:: : ::.::: .:. . :: : .. : : ::::: .. .: CCDS47 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 530 540 550 560 570 580 230 240 250 260 270 pF1KSD AKILLEAGADTTIVNNAGQTPLETARYHNNPEVA-LLLTK--APQGSVSAGDTPSSEQAV :..::: : . ... : :::..: .::: ... ::: . .:.. . : :: CCDS47 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 590 600 610 620 630 640 280 290 300 310 320 330 pF1KSD ARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKR CCDS47 QNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTP 650 660 670 680 690 700 >>CCDS54796.1 ANK2 gene_id:287|Hs108|chr4 (1863 aa) initn: 433 init1: 433 opt: 454 Z-score: 330.6 bits: 73.1 E(32554): 4.3e-12 Smith-Waterman score: 454; 34.8% identity (64.8% similar) in 264 aa overlap (14-273:381-644) 10 20 30 40 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARV-AVTKHG : .: :.. . . :.. :: . :.:. : CCDS54 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 360 370 380 390 400 410 50 60 70 80 90 100 pF1KSD RTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALD ::.:.:: ::: .: .::. : . :: . .:::: :. .:..:.. :...: .: CCDS54 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 420 430 440 450 460 470 110 120 130 140 150 160 pF1KSD RQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLL . .. .: :: :: : .. ..::.. :. : . : : ::.. .... . . ::: CCDS54 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 480 490 500 510 520 530 170 180 190 200 210 220 pF1KSD AGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKV ::. .: .. : : :::::.:. :.. .::: .. .. : : ::::: ...:: CCDS54 AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 540 550 560 570 580 590 230 240 250 260 270 pF1KSD AKILLEAGADTTIVNNAGQTPLETARYHNNPEVA-LLLTKAPQGSV--SAGDTPSSEQAV : .::: ::. . . : :::. : .:. ..: ::. . . .. . : :: CCDS54 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 600 610 620 630 640 650 280 290 300 310 320 330 pF1KSD ARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKR CCDS54 EGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTP 660 670 680 690 700 710 >>CCDS7050.2 EHMT1 gene_id:79813|Hs108|chr9 (1298 aa) initn: 614 init1: 219 opt: 451 Z-score: 330.6 bits: 72.5 E(32554): 4.3e-12 Smith-Waterman score: 451; 30.1% identity (62.4% similar) in 279 aa overlap (12-286:740-1016) 10 20 30 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVT-- ..: .: .:. ..:. .. : CCDS70 GLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKME 710 720 730 740 750 760 40 50 60 70 80 90 pF1KSD -KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEG .. :.::: ::. ::. . ..:..:: ..:. .. ..: : .:. .. : . ::. : CCDS70 HQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAG 770 780 790 800 810 820 100 110 120 130 140 150 pF1KSD CALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA-NVLAKNKAGNTALHLACQNSHSQST .: .: .:.: :: :. .: . .. :.. : .: .. .: : . : . .: . . CCDS70 ALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLV 830 840 850 860 870 880 160 170 180 190 200 210 pF1KSD RVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAAL ..:: :: ....: . ::: :: . ..: ..::.: :..: : ::. ::.:: CCDS70 KLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARE 890 900 910 920 930 940 220 230 240 250 260 270 pF1KSD NHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQGSVSAGDTPSSEQ :. . ..: .:.:. :. :.:::. : ... :: ..:: : : : : :: . CCDS70 NRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDS--APDRPSPVE 950 960 970 980 990 1000 280 290 300 310 320 330 pF1KSD AVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPK .. .. :: CCDS70 RIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDD 1010 1020 1030 1040 1050 1060 >>CCDS43261.1 ANK2 gene_id:287|Hs108|chr4 (1872 aa) initn: 750 init1: 433 opt: 454 Z-score: 330.6 bits: 73.1 E(32554): 4.3e-12 Smith-Waterman score: 454; 34.8% identity (64.8% similar) in 264 aa overlap (14-273:402-665) 10 20 30 40 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARV-AVTKHG : .: :.. . . :.. :: . :.:. : CCDS43 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 380 390 400 410 420 430 50 60 70 80 90 100 pF1KSD RTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALD ::.:.:: ::: .: .::. : . :: . .:::: :. .:..:.. :...: .: CCDS43 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 440 450 460 470 480 490 110 120 130 140 150 160 pF1KSD RQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLL . .. .: :: :: : .. ..::.. :. : . : : ::.. .... . . ::: CCDS43 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 500 510 520 530 540 550 170 180 190 200 210 220 pF1KSD AGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKV ::. .: .. : : :::::.:. :.. .::: .. .. : : ::::: ...:: CCDS43 AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 560 570 580 590 600 610 230 240 250 260 270 pF1KSD AKILLEAGADTTIVNNAGQTPLETARYHNNPEVA-LLLTKAPQGSV--SAGDTPSSEQAV : .::: ::. . . : :::. : .:. ..: ::. . . .. . : :: CCDS43 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 620 630 640 650 660 670 280 290 300 310 320 330 pF1KSD ARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKR CCDS43 EGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTP 680 690 700 710 720 730 692 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 04:24:11 2016 done: Thu Nov 3 04:24:12 2016 Total Scan time: 4.250 Total Display time: 0.150 Function used was FASTA [36.3.4 Apr, 2011]