FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA0957, 692 aa 1>>>pF1KSDA0957 692 - 692 aa - 692 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.8574+/-0.000455; mu= 4.2472+/- 0.028 mean_var=254.7418+/-53.246, 0's: 0 Z-trim(119.6): 674 B-trim: 1017 in 1/52 Lambda= 0.080357 statistics sampled from 33001 (33805) to 33001 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.724), E-opt: 0.2 (0.396), width: 16 Scan time: 9.610 The best scores are: opt bits E(85289) NP_001229742 (OMIM: 610583) ankyrin repeat domain- ( 692) 4525 538.4 3.4e-152 XP_016865987 (OMIM: 610583) PREDICTED: ankyrin rep ( 687) 4476 532.7 1.7e-150 XP_016865982 (OMIM: 610583) PREDICTED: ankyrin rep ( 717) 4064 485.0 4.3e-136 XP_016865984 (OMIM: 610583) PREDICTED: ankyrin rep ( 694) 4029 480.9 7e-135 XP_016865986 (OMIM: 610583) PREDICTED: ankyrin rep ( 689) 3980 475.2 3.5e-133 XP_016865994 (OMIM: 610583) PREDICTED: ankyrin rep ( 659) 3784 452.5 2.4e-126 XP_011533901 (OMIM: 610583) PREDICTED: ankyrin rep ( 694) 3757 449.4 2.2e-125 XP_016865991 (OMIM: 610583) PREDICTED: ankyrin rep ( 661) 3586 429.5 1.9e-119 XP_011533898 (OMIM: 610583) PREDICTED: ankyrin rep ( 719) 3568 427.5 8.7e-119 XP_016865983 (OMIM: 610583) PREDICTED: ankyrin rep ( 714) 3519 421.8 4.5e-117 XP_016865993 (OMIM: 610583) PREDICTED: ankyrin rep ( 659) 3505 420.1 1.3e-116 XP_016865985 (OMIM: 610583) PREDICTED: ankyrin rep ( 694) 3433 411.8 4.4e-114 XP_011533900 (OMIM: 610583) PREDICTED: ankyrin rep ( 694) 3433 411.8 4.4e-114 XP_016865988 (OMIM: 610583) PREDICTED: ankyrin rep ( 684) 3410 409.1 2.8e-113 XP_016865998 (OMIM: 610583) PREDICTED: ankyrin rep ( 626) 3372 404.7 5.5e-112 XP_016866000 (OMIM: 610583) PREDICTED: ankyrin rep ( 593) 3328 399.6 1.8e-110 XP_016865999 (OMIM: 610583) PREDICTED: ankyrin rep ( 593) 3328 399.6 1.8e-110 XP_016865992 (OMIM: 610583) PREDICTED: ankyrin rep ( 661) 3314 398.0 6e-110 XP_011533899 (OMIM: 610583) PREDICTED: ankyrin rep ( 719) 3296 396.0 2.7e-109 XP_016865996 (OMIM: 610583) PREDICTED: ankyrin rep ( 656) 3239 389.3 2.5e-107 NP_001229740 (OMIM: 610583) ankyrin repeat domain- ( 727) 3229 388.2 6e-107 NP_001229738 (OMIM: 610583) ankyrin repeat domain- ( 727) 3229 388.2 6e-107 XP_005248738 (OMIM: 610583) PREDICTED: ankyrin rep ( 727) 3229 388.2 6e-107 XP_005248736 (OMIM: 610583) PREDICTED: ankyrin rep ( 752) 3208 385.8 3.3e-106 XP_016865990 (OMIM: 610583) PREDICTED: ankyrin rep ( 661) 3162 380.4 1.2e-104 XP_005248737 (OMIM: 610583) PREDICTED: ankyrin rep ( 747) 3159 380.1 1.7e-104 XP_016865995 (OMIM: 610583) PREDICTED: ankyrin rep ( 656) 3113 374.7 6.2e-103 XP_016865997 (OMIM: 610583) PREDICTED: ankyrin rep ( 628) 3083 371.2 6.7e-102 XP_005248740 (OMIM: 610583) PREDICTED: ankyrin rep ( 686) 3067 369.4 2.6e-101 XP_016865989 (OMIM: 610583) PREDICTED: ankyrin rep ( 681) 3018 363.7 1.3e-99 XP_016866002 (OMIM: 610583) PREDICTED: ankyrin rep ( 567) 2986 359.9 1.5e-98 XP_016866001 (OMIM: 610583) PREDICTED: ankyrin rep ( 567) 2986 359.9 1.5e-98 XP_005248741 (OMIM: 610583) PREDICTED: ankyrin rep ( 592) 2911 351.2 6.5e-96 XP_016866003 (OMIM: 610583) PREDICTED: ankyrin rep ( 534) 2901 350.0 1.3e-95 XP_016866004 (OMIM: 610583) PREDICTED: ankyrin rep ( 493) 2851 344.2 7e-94 XP_005248739 (OMIM: 610583) PREDICTED: ankyrin rep ( 726) 2842 343.3 1.9e-93 XP_011533902 (OMIM: 610583) PREDICTED: ankyrin rep ( 663) 2793 337.6 9.2e-92 NP_001229743 (OMIM: 610583) ankyrin repeat domain- ( 663) 2793 337.6 9.2e-92 NP_055757 (OMIM: 610583) ankyrin repeat domain-con ( 722) 1746 216.3 3.4e-55 XP_016863596 (OMIM: 106410,600919) PREDICTED: anky (1797) 466 68.3 3e-10 XP_016863595 (OMIM: 106410,600919) PREDICTED: anky (1806) 466 68.3 3e-10 XP_016863591 (OMIM: 106410,600919) PREDICTED: anky (1838) 466 68.3 3.1e-10 XP_016863589 (OMIM: 106410,600919) PREDICTED: anky (1846) 466 68.3 3.1e-10 XP_016863586 (OMIM: 106410,600919) PREDICTED: anky (1858) 466 68.3 3.1e-10 XP_016863580 (OMIM: 106410,600919) PREDICTED: anky (1879) 466 68.3 3.1e-10 XP_011517331 (OMIM: 607001,610253) PREDICTED: hist ( 775) 451 66.2 5.5e-10 NP_065210 (OMIM: 182900,612641) ankyrin-1 isoform (1719) 456 67.1 6.5e-10 XP_011542807 (OMIM: 182900,612641) PREDICTED: anky (1751) 456 67.1 6.6e-10 XP_011542806 (OMIM: 182900,612641) PREDICTED: anky (1752) 456 67.1 6.6e-10 XP_016868818 (OMIM: 182900,612641) PREDICTED: anky (1759) 456 67.1 6.6e-10 >>NP_001229742 (OMIM: 610583) ankyrin repeat domain-cont (692 aa) initn: 4525 init1: 4525 opt: 4525 Z-score: 2853.4 bits: 538.4 E(85289): 3.4e-152 Smith-Waterman score: 4525; 99.9% identity (100.0% similar) in 692 aa overlap (1-692:1-692) 10 20 30 40 50 60 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD QTPLETARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QTPLETARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD LYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD HQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KLSGDSRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLSGDSRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD QELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD PAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQAN 610 620 630 640 650 660 670 680 690 pF1KSD QKAQQDKATLKEHIKSLEEELAKLRTRVQKEN :::::::::::::::::::::::::::::::: NP_001 QKAQQDKATLKEHIKSLEEELAKLRTRVQKEN 670 680 690 >>XP_016865987 (OMIM: 610583) PREDICTED: ankyrin repeat (687 aa) initn: 3274 init1: 3274 opt: 4476 Z-score: 2822.7 bits: 532.7 E(85289): 1.7e-150 Smith-Waterman score: 4476; 99.1% identity (99.3% similar) in 692 aa overlap (1-692:1-687) 10 20 30 40 50 60 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD QTPLETARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTPLETARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD LYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD HQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KLSGDSRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQ :::::::::::::::::: ::::::::::::::::::::::::::::::::::::: XP_016 KLSGDSRACRAKSTPSTC-----VDQLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQ 490 500 510 520 530 550 560 570 580 590 600 pF1KSD QELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQ 540 550 560 570 580 590 610 620 630 640 650 660 pF1KSD PAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQAN 600 610 620 630 640 650 670 680 690 pF1KSD QKAQQDKATLKEHIKSLEEELAKLRTRVQKEN :::::::::::::::::::::::::::::::: XP_016 QKAQQDKATLKEHIKSLEEELAKLRTRVQKEN 660 670 680 >>XP_016865982 (OMIM: 610583) PREDICTED: ankyrin repeat (717 aa) initn: 4064 init1: 4064 opt: 4064 Z-score: 2564.3 bits: 485.0 E(85289): 4.3e-136 Smith-Waterman score: 4064; 99.4% identity (99.8% similar) in 622 aa overlap (71-692:96-717) 50 60 70 80 90 100 pF1KSD HGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCA . .::::::::::::::::::::::::::: XP_016 AVATVKAMKEDKNKKNHRGKVRKDPRRSEREKEGDQTALHRATVVGNTEIIAALIHEGCA 70 80 90 100 110 120 110 120 130 140 150 160 pF1KSD LDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVL :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: XP_016 LDRQDKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVL 130 140 150 160 170 180 170 180 190 200 210 220 pF1KSD LLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHK 190 200 210 220 230 240 230 240 250 260 270 280 pF1KSD KVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVA 250 260 270 280 290 300 290 300 310 320 330 340 pF1KSD RKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRN 310 320 330 340 350 360 350 360 370 380 390 400 pF1KSD RHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAE 370 380 390 400 410 420 410 420 430 440 450 460 pF1KSD LGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQ 430 440 450 460 470 480 470 480 490 500 510 520 pF1KSD ISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSS 490 500 510 520 530 540 530 540 550 560 570 580 pF1KSD PPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVN 550 560 570 580 590 600 590 600 610 620 630 640 pF1KSD RGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAV 610 620 630 640 650 660 650 660 670 680 690 pF1KSD STQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLRTRVQKEN :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLRTRVQKEN 670 680 690 700 710 >>XP_016865984 (OMIM: 610583) PREDICTED: ankyrin repeat (694 aa) initn: 4055 init1: 2842 opt: 4029 Z-score: 2542.6 bits: 480.9 E(85289): 7e-135 Smith-Waterman score: 4149; 90.5% identity (90.6% similar) in 727 aa overlap (1-692:1-694) 10 20 30 40 50 60 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV :::::::.:::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDT---- 130 140 150 160 170 190 200 210 220 230 240 pF1KSD AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG ::::::::::::::::::::::::::::::: XP_016 -----------------------------ALHVAAALNHKKVAKILLEAGADTTIVNNAG 180 190 200 250 260 pF1KSD QTPLETARYHNNPEVALLLTKAPQ-----------------------------------G :::::::::::::::::::::::: : XP_016 QTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKG 210 220 230 240 250 260 270 280 290 300 310 320 pF1KSD SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG 270 280 290 300 310 320 330 340 350 360 370 380 pF1KSD HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK 330 340 350 360 370 380 390 400 410 420 430 440 pF1KSD LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL 390 400 410 420 430 440 450 460 470 480 490 500 pF1KSD QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVD 450 460 470 480 490 500 510 520 530 540 550 560 pF1KSD QLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPM 510 520 530 540 550 560 570 580 590 600 610 620 pF1KSD NEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRD 570 580 590 600 610 620 630 640 650 660 670 680 pF1KSD TSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLR 630 640 650 660 670 680 690 pF1KSD TRVQKEN ::::::: XP_016 TRVQKEN 690 >>XP_016865986 (OMIM: 610583) PREDICTED: ankyrin repeat (689 aa) initn: 2804 init1: 1591 opt: 3980 Z-score: 2511.9 bits: 475.2 E(85289): 3.5e-133 Smith-Waterman score: 4100; 89.8% identity (90.0% similar) in 727 aa overlap (1-692:1-689) 10 20 30 40 50 60 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD SQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV :::::::.:::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDT---- 130 140 150 160 170 190 200 210 220 230 240 pF1KSD AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG ::::::::::::::::::::::::::::::: XP_016 -----------------------------ALHVAAALNHKKVAKILLEAGADTTIVNNAG 180 190 200 250 260 pF1KSD QTPLETARYHNNPEVALLLTKAPQ-----------------------------------G :::::::::::::::::::::::: : XP_016 QTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKG 210 220 230 240 250 260 270 280 290 300 310 320 pF1KSD SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG 270 280 290 300 310 320 330 340 350 360 370 380 pF1KSD HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK 330 340 350 360 370 380 390 400 410 420 430 440 pF1KSD LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL 390 400 410 420 430 440 450 460 470 480 490 500 pF1KSD QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVD ::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_016 QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTC-----VD 450 460 470 480 490 500 510 520 530 540 550 560 pF1KSD QLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPM 510 520 530 540 550 560 570 580 590 600 610 620 pF1KSD NEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRD 570 580 590 600 610 620 630 640 650 660 670 680 pF1KSD TSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLR 630 640 650 660 670 680 690 pF1KSD TRVQKEN ::::::: XP_016 TRVQKEN >>XP_016865994 (OMIM: 610583) PREDICTED: ankyrin repeat (659 aa) initn: 3756 init1: 3756 opt: 3784 Z-score: 2389.4 bits: 452.5 E(85289): 2.4e-126 Smith-Waterman score: 4237; 95.2% identity (95.2% similar) in 692 aa overlap (1-692:1-659) 10 20 30 40 50 60 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF :::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDK-------------- 70 80 90 100 130 140 150 160 170 180 pF1KSD SQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV ::::::::::::::::::::::::::::::::::::::::: XP_016 -------------------AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV 110 120 130 140 190 200 210 220 230 240 pF1KSD AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG 150 160 170 180 190 200 250 260 270 280 290 300 pF1KSD QTPLETARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTPLETARYHNNPEVALLLTKAPQGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKD 210 220 230 240 250 260 310 320 330 340 350 360 pF1KSD DRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRRRKSRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYT 270 280 290 300 310 320 370 380 390 400 410 420 pF1KSD LYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYRGKDGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQ 330 340 350 360 370 380 430 440 450 460 470 480 pF1KSD HQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQMRVLDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQ 390 400 410 420 430 440 490 500 510 520 530 540 pF1KSD KLSGDSRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLSGDSRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQ 450 460 470 480 490 500 550 560 570 580 590 600 pF1KSD QELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QELSSSDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQ 510 520 530 540 550 560 610 620 630 640 650 660 pF1KSD PAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAASSTCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQAN 570 580 590 600 610 620 670 680 690 pF1KSD QKAQQDKATLKEHIKSLEEELAKLRTRVQKEN :::::::::::::::::::::::::::::::: XP_016 QKAQQDKATLKEHIKSLEEELAKLRTRVQKEN 630 640 650 >>XP_011533901 (OMIM: 610583) PREDICTED: ankyrin repeat (694 aa) initn: 3783 init1: 2842 opt: 3757 Z-score: 2372.2 bits: 449.4 E(85289): 2.2e-125 Smith-Waterman score: 4157; 90.6% identity (90.6% similar) in 727 aa overlap (1-692:1-694) 10 20 30 40 50 60 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF :::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDK-------------- 70 80 90 100 130 140 150 160 170 180 pF1KSD SQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV ::::::::::::::::::::::::::::::::::::::::: XP_011 -------------------AGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV 110 120 130 140 190 200 210 220 230 240 pF1KSD AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG 150 160 170 180 190 200 250 260 pF1KSD QTPLETARYHNNPEVALLLTKAPQ-----------------------------------G :::::::::::::::::::::::: : XP_011 QTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKG 210 220 230 240 250 260 270 280 290 300 310 320 pF1KSD SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG 270 280 290 300 310 320 330 340 350 360 370 380 pF1KSD HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK 330 340 350 360 370 380 390 400 410 420 430 440 pF1KSD LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL 390 400 410 420 430 440 450 460 470 480 490 500 pF1KSD QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVD 450 460 470 480 490 500 510 520 530 540 550 560 pF1KSD QLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPM 510 520 530 540 550 560 570 580 590 600 610 620 pF1KSD NEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRD 570 580 590 600 610 620 630 640 650 660 670 680 pF1KSD TSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLR 630 640 650 660 670 680 690 pF1KSD TRVQKEN ::::::: XP_011 TRVQKEN 690 >>XP_016865991 (OMIM: 610583) PREDICTED: ankyrin repeat (661 aa) initn: 3591 init1: 2842 opt: 3586 Z-score: 2265.3 bits: 429.5 E(85289): 1.9e-119 Smith-Waterman score: 3844; 86.0% identity (86.1% similar) in 727 aa overlap (1-692:1-661) 10 20 30 40 50 60 pF1KSD MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTKHGRTPLHLAANKGHLPVVQI :::::::::::::::::::::::::::::::::::::::: XP_016 MSQQDAVAALSERLLVAAYKGQTENVVQLINKGARVAVTK-------------------- 10 20 30 40 70 80 90 100 110 120 pF1KSD LLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 -------------GDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGF 50 60 70 80 130 140 150 160 170 180 pF1KSD SQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV :::::::.:::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDT---- 90 100 110 120 130 140 190 200 210 220 230 240 pF1KSD AARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAG ::::::::::::::::::::::::::::::: XP_016 -----------------------------ALHVAAALNHKKVAKILLEAGADTTIVNNAG 150 160 170 250 260 pF1KSD QTPLETARYHNNPEVALLLTKAPQ-----------------------------------G :::::::::::::::::::::::: : XP_016 QTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRERLKEERRAQSVPRDEVAQSKG 180 190 200 210 220 230 270 280 290 300 310 320 pF1KSD SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRKSRPKVSAFSDPTPPADQQPG 240 250 260 270 280 290 330 340 350 360 370 380 pF1KSD HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGKDGKVMQAPINGCRCEPLINK 300 310 320 330 340 350 390 400 410 420 430 440 pF1KSD LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRVLDKLMVERLSAERTECLNRL 360 370 380 390 400 410 450 460 470 480 490 500 pF1KSD QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGDSRACRAKSTPSTCESSTGVD 420 430 440 450 460 470 510 520 530 540 550 560 pF1KSD QLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSSSDCTGSRLRNVKVQTALLPM 480 490 500 510 520 530 570 580 590 600 610 620 pF1KSD NEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASSTCGQPPPATGSEQTGPHIRD 540 550 560 570 580 590 630 640 650 660 670 680 pF1KSD TSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQDKATLKEHIKSLEEELAKLR 600 610 620 630 640 650 690 pF1KSD TRVQKEN ::::::: XP_016 TRVQKEN 660 >>XP_011533898 (OMIM: 610583) PREDICTED: ankyrin repeat (719 aa) initn: 3594 init1: 2842 opt: 3568 Z-score: 2253.6 bits: 427.5 E(85289): 8.7e-119 Smith-Waterman score: 3688; 89.0% identity (89.5% similar) in 657 aa overlap (71-692:96-719) 50 60 70 80 90 100 pF1KSD HGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCA . .::::::::::::::::::::::::::: XP_011 AVATVKAMKEDKNKKNHRGKVRKDPRRSEREKEGDQTALHRATVVGNTEIIAALIHEGCA 70 80 90 100 110 120 110 120 130 140 150 160 pF1KSD LDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVL :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: XP_011 LDRQDKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVL 130 140 150 160 170 180 170 180 190 200 210 220 pF1KSD LLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHK :::::::::::::::: ::::::::::: XP_011 LLAGSRADLKNNAGDT---------------------------------ALHVAAALNHK 190 200 210 230 240 250 260 pF1KSD KVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQ---------------- :::::::::::::::::::::::::::::::::::::::::::: XP_011 KVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRER 220 230 240 250 260 270 270 280 290 300 pF1KSD -------------------GSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRK ::::::::::::::::::::::::::::::::::::::::: XP_011 LKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRK 280 290 300 310 320 330 310 320 330 340 350 360 pF1KSD SRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGK 340 350 360 370 380 390 370 380 390 400 410 420 pF1KSD DGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRV 400 410 420 430 440 450 430 440 450 460 470 480 pF1KSD LDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGD 460 470 480 490 500 510 490 500 510 520 530 540 pF1KSD SRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSS 520 530 540 550 560 570 550 560 570 580 590 600 pF1KSD SDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASS 580 590 600 610 620 630 610 620 630 640 650 660 pF1KSD TCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQ 640 650 660 670 680 690 670 680 690 pF1KSD DKATLKEHIKSLEEELAKLRTRVQKEN ::::::::::::::::::::::::::: XP_011 DKATLKEHIKSLEEELAKLRTRVQKEN 700 710 >>XP_016865983 (OMIM: 610583) PREDICTED: ankyrin repeat (714 aa) initn: 2343 init1: 1591 opt: 3519 Z-score: 2222.9 bits: 421.8 E(85289): 4.5e-117 Smith-Waterman score: 3639; 88.3% identity (88.7% similar) in 657 aa overlap (71-692:96-714) 50 60 70 80 90 100 pF1KSD HGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCA . .::::::::::::::::::::::::::: XP_016 AVATVKAMKEDKNKKNHRGKVRKDPRRSEREKEGDQTALHRATVVGNTEIIAALIHEGCA 70 80 90 100 110 120 110 120 130 140 150 160 pF1KSD LDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVL :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: XP_016 LDRQDKDGNTALHEASWHGFSQSAKLLIKAGANVLAKNKAGNTALHLACQNSHSQSTRVL 130 140 150 160 170 180 170 180 190 200 210 220 pF1KSD LLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHK :::::::::::::::: ::::::::::: XP_016 LLAGSRADLKNNAGDT---------------------------------ALHVAAALNHK 190 200 210 230 240 250 260 pF1KSD KVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQ---------------- :::::::::::::::::::::::::::::::::::::::::::: XP_016 KVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQVLRFSRGRSLRKKRER 220 230 240 250 260 270 270 280 290 300 pF1KSD -------------------GSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRK ::::::::::::::::::::::::::::::::::::::::: XP_016 LKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREEFLSASPEPRAKDDRRRK 280 290 300 310 320 330 310 320 330 340 350 360 pF1KSD SRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRPKVSAFSDPTPPADQQPGHQKNLHAHNHPKKRNRHRCSSPPPPHEFRAYQLYTLYRGK 340 350 360 370 380 390 370 380 390 400 410 420 pF1KSD DGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGKVMQAPINGCRCEPLINKLENQLEATVEEIKAELGSVQDKMNTKLGQMENKTQHQMRV 400 410 420 430 440 450 430 440 450 460 470 480 pF1KSD LDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDKLMVERLSAERTECLNRLQQHSDTEKHEGEKRQISLVDELKTWCMLKIQNLEQKLSGD 460 470 480 490 500 510 490 500 510 520 530 540 pF1KSD SRACRAKSTPSTCESSTGVDQLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSS ::::::::::::: :::::::::::::::::::::::::::::::::::::::::: XP_016 SRACRAKSTPSTC-----VDQLVVTAGPAAASDSSPPVVRPKEKALNSTATQRLQQELSS 520 530 540 550 560 550 560 570 580 590 600 pF1KSD SDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDCTGSRLRNVKVQTALLPMNEAARSDQQAGPCVNRGTQTKKSGKSGPTRHRAQQPAASS 570 580 590 600 610 620 610 620 630 640 650 660 pF1KSD TCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TCGQPPPATGSEQTGPHIRDTSQALELTQYFFEAVSTQMEKWYERKIEEARSQANQKAQQ 630 640 650 660 670 680 670 680 690 pF1KSD DKATLKEHIKSLEEELAKLRTRVQKEN ::::::::::::::::::::::::::: XP_016 DKATLKEHIKSLEEELAKLRTRVQKEN 690 700 710 692 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 04:24:12 2016 done: Thu Nov 3 04:24:13 2016 Total Scan time: 9.610 Total Display time: 0.160 Function used was FASTA [36.3.4 Apr, 2011]