Result of FASTA (omim) for
pF1KSDA0967
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0967, 1578 aa
1>>>pF1KSDA0967 1578 - 1578 aa - 1578 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.7863+/-0.000407; mu= 2.8007+/- 0.025
mean_var=202.6556+/-41.470, 0's: 0 Z-trim(118.7): 23 B-trim: 1363 in 1/61
Lambda= 0.090094
statistics sampled from 31964 (31986) to 31964 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.698), E-opt: 0.2 (0.375), width: 16
Scan time: 17.220
The best scores are: opt bits E(85289)
NP_055722 (OMIM: 616919) FERM and PDZ domain-conta (1578) 10506 1379.3 0
XP_016869969 (OMIM: 616919) PREDICTED: FERM and PD (1578) 10506 1379.3 0
XP_011516106 (OMIM: 616919) PREDICTED: FERM and PD (1578) 10506 1379.3 0
XP_011516105 (OMIM: 616919) PREDICTED: FERM and PD (1578) 10506 1379.3 0
XP_011516108 (OMIM: 616919) PREDICTED: FERM and PD (1452) 9628 1265.2 0
XP_011516107 (OMIM: 616919) PREDICTED: FERM and PD (1453) 9628 1265.2 0
XP_016869971 (OMIM: 616919) PREDICTED: FERM and PD (1453) 9628 1265.2 0
XP_016869970 (OMIM: 616919) PREDICTED: FERM and PD (1469) 9628 1265.2 0
XP_016885475 (OMIM: 300830,300838,300983) PREDICTE (1319) 1515 210.7 6.9e-53
NP_055543 (OMIM: 300830,300838,300983) FERM and PD (1322) 1515 210.7 6.9e-53
XP_016885474 (OMIM: 300830,300838,300983) PREDICTE (1346) 1515 210.7 7e-53
XP_016885472 (OMIM: 300830,300838,300983) PREDICTE (1759) 1515 210.7 8.9e-53
XP_011543915 (OMIM: 300830,300838,300983) PREDICTE (1762) 1515 210.7 8.9e-53
XP_005274689 (OMIM: 300830,300838,300983) PREDICTE (1786) 1515 210.7 9e-53
XP_016885473 (OMIM: 300830,300838,300983) PREDICTE (1756) 1113 158.4 4.7e-37
XP_005259549 (OMIM: 601869,608792) PREDICTED: PDZ (1349) 282 50.4 0.00012
>>NP_055722 (OMIM: 616919) FERM and PDZ domain-containin (1578 aa)
initn: 10506 init1: 10506 opt: 10506 Z-score: 7385.1 bits: 1379.3 E(85289): 0
Smith-Waterman score: 10506; 99.9% identity (99.9% similar) in 1578 aa overlap (1-1578:1-1578)
10 20 30 40 50 60
pF1KSD MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KSD PCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
NP_055 PCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KSD MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KSD RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KSD GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KSD AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
1510 1520 1530 1540 1550 1560
1570
pF1KSD LTAAVFCLTQKFRASTAL
::::::::::::::::::
NP_055 LTAAVFCLTQKFRASTAL
1570
>>XP_016869969 (OMIM: 616919) PREDICTED: FERM and PDZ do (1578 aa)
initn: 10506 init1: 10506 opt: 10506 Z-score: 7385.1 bits: 1379.3 E(85289): 0
Smith-Waterman score: 10506; 99.9% identity (99.9% similar) in 1578 aa overlap (1-1578:1-1578)
10 20 30 40 50 60
pF1KSD MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KSD PCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
XP_016 PCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KSD MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KSD RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KSD GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KSD AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
1510 1520 1530 1540 1550 1560
1570
pF1KSD LTAAVFCLTQKFRASTAL
::::::::::::::::::
XP_016 LTAAVFCLTQKFRASTAL
1570
>>XP_011516106 (OMIM: 616919) PREDICTED: FERM and PDZ do (1578 aa)
initn: 10506 init1: 10506 opt: 10506 Z-score: 7385.1 bits: 1379.3 E(85289): 0
Smith-Waterman score: 10506; 99.9% identity (99.9% similar) in 1578 aa overlap (1-1578:1-1578)
10 20 30 40 50 60
pF1KSD MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KSD PCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
XP_011 PCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KSD MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KSD RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KSD GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KSD AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
1510 1520 1530 1540 1550 1560
1570
pF1KSD LTAAVFCLTQKFRASTAL
::::::::::::::::::
XP_011 LTAAVFCLTQKFRASTAL
1570
>>XP_011516105 (OMIM: 616919) PREDICTED: FERM and PDZ do (1578 aa)
initn: 10506 init1: 10506 opt: 10506 Z-score: 7385.1 bits: 1379.3 E(85289): 0
Smith-Waterman score: 10506; 99.9% identity (99.9% similar) in 1578 aa overlap (1-1578:1-1578)
10 20 30 40 50 60
pF1KSD MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEELETSLFQTRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKDTLLQDYGFHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHSQGNSLLCMP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISRLHLLHE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAESEASDSANTESRGY
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGFLCLLD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGSSDEEYYDAADKLTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRGGVKKYAKTLRKRRS
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRD
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDV
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSREPPGQGCQAQEQKL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPEWVCFNPEPSLPEPL
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KSD PCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
XP_011 PCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAG
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KSD MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPLTSPPSAGSPVVLPW
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KSD RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLMESLLELQDILETSW
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KSD GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEMQGAVRDTFQHLVQL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KSD AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGYHDLSVKLLARQCTA
1510 1520 1530 1540 1550 1560
1570
pF1KSD LTAAVFCLTQKFRASTAL
::::::::::::::::::
XP_011 LTAAVFCLTQKFRASTAL
1570
>>XP_011516108 (OMIM: 616919) PREDICTED: FERM and PDZ do (1452 aa)
initn: 9628 init1: 9628 opt: 9628 Z-score: 6768.9 bits: 1265.2 E(85289): 0
Smith-Waterman score: 9628; 99.9% identity (99.9% similar) in 1442 aa overlap (137-1578:11-1452)
110 120 130 140 150 160
pF1KSD PAEDLSWERAVDILREAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
::::::::::::::::::::::::::::::
XP_011 MNLIGSDLFLGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
10 20 30 40
170 180 190 200 210 220
pF1KSD ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
50 60 70 80 90 100
230 240 250 260 270 280
pF1KSD EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
110 120 130 140 150 160
290 300 310 320 330 340
pF1KSD SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
170 180 190 200 210 220
350 360 370 380 390 400
pF1KSD RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
230 240 250 260 270 280
410 420 430 440 450 460
pF1KSD LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
290 300 310 320 330 340
470 480 490 500 510 520
pF1KSD KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
350 360 370 380 390 400
530 540 550 560 570 580
pF1KSD EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
410 420 430 440 450 460
590 600 610 620 630 640
pF1KSD SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
470 480 490 500 510 520
650 660 670 680 690 700
pF1KSD RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
530 540 550 560 570 580
710 720 730 740 750 760
pF1KSD YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
590 600 610 620 630 640
770 780 790 800 810 820
pF1KSD SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
650 660 670 680 690 700
830 840 850 860 870 880
pF1KSD GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
710 720 730 740 750 760
890 900 910 920 930 940
pF1KSD LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
770 780 790 800 810 820
950 960 970 980 990 1000
pF1KSD RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
830 840 850 860 870 880
1010 1020 1030 1040 1050 1060
pF1KSD EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
890 900 910 920 930 940
1070 1080 1090 1100 1110 1120
pF1KSD TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
950 960 970 980 990 1000
1130 1140 1150 1160 1170 1180
pF1KSD EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
1010 1020 1030 1040 1050 1060
1190 1200 1210 1220 1230 1240
pF1KSD EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
1070 1080 1090 1100 1110 1120
1250 1260 1270 1280 1290 1300
pF1KSD WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEV
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
XP_011 WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEV
1130 1140 1150 1160 1170 1180
1310 1320 1330 1340 1350 1360
pF1KSD SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
1190 1200 1210 1220 1230 1240
1370 1380 1390 1400 1410 1420
pF1KSD TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
1250 1260 1270 1280 1290 1300
1430 1440 1450 1460 1470 1480
pF1KSD ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
1310 1320 1330 1340 1350 1360
1490 1500 1510 1520 1530 1540
pF1KSD QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
1370 1380 1390 1400 1410 1420
1550 1560 1570
pF1KSD HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
::::::::::::::::::::::::::::::::
XP_011 HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
1430 1440 1450
>>XP_011516107 (OMIM: 616919) PREDICTED: FERM and PDZ do (1453 aa)
initn: 9628 init1: 9628 opt: 9628 Z-score: 6768.9 bits: 1265.2 E(85289): 0
Smith-Waterman score: 9628; 99.9% identity (99.9% similar) in 1442 aa overlap (137-1578:12-1453)
110 120 130 140 150 160
pF1KSD PAEDLSWERAVDILREAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
::::::::::::::::::::::::::::::
XP_011 MASALPGQLGPGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
10 20 30 40
170 180 190 200 210 220
pF1KSD ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
50 60 70 80 90 100
230 240 250 260 270 280
pF1KSD EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
110 120 130 140 150 160
290 300 310 320 330 340
pF1KSD SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
170 180 190 200 210 220
350 360 370 380 390 400
pF1KSD RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
230 240 250 260 270 280
410 420 430 440 450 460
pF1KSD LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
290 300 310 320 330 340
470 480 490 500 510 520
pF1KSD KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
350 360 370 380 390 400
530 540 550 560 570 580
pF1KSD EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
410 420 430 440 450 460
590 600 610 620 630 640
pF1KSD SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
470 480 490 500 510 520
650 660 670 680 690 700
pF1KSD RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
530 540 550 560 570 580
710 720 730 740 750 760
pF1KSD YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
590 600 610 620 630 640
770 780 790 800 810 820
pF1KSD SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
650 660 670 680 690 700
830 840 850 860 870 880
pF1KSD GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
710 720 730 740 750 760
890 900 910 920 930 940
pF1KSD LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
770 780 790 800 810 820
950 960 970 980 990 1000
pF1KSD RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
830 840 850 860 870 880
1010 1020 1030 1040 1050 1060
pF1KSD EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
890 900 910 920 930 940
1070 1080 1090 1100 1110 1120
pF1KSD TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
950 960 970 980 990 1000
1130 1140 1150 1160 1170 1180
pF1KSD EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
1010 1020 1030 1040 1050 1060
1190 1200 1210 1220 1230 1240
pF1KSD EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
1070 1080 1090 1100 1110 1120
1250 1260 1270 1280 1290 1300
pF1KSD WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEV
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
XP_011 WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEV
1130 1140 1150 1160 1170 1180
1310 1320 1330 1340 1350 1360
pF1KSD SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
1190 1200 1210 1220 1230 1240
1370 1380 1390 1400 1410 1420
pF1KSD TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
1250 1260 1270 1280 1290 1300
1430 1440 1450 1460 1470 1480
pF1KSD ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
1310 1320 1330 1340 1350 1360
1490 1500 1510 1520 1530 1540
pF1KSD QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
1370 1380 1390 1400 1410 1420
1550 1560 1570
pF1KSD HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
::::::::::::::::::::::::::::::::
XP_011 HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
1430 1440 1450
>>XP_016869971 (OMIM: 616919) PREDICTED: FERM and PDZ do (1453 aa)
initn: 9628 init1: 9628 opt: 9628 Z-score: 6768.9 bits: 1265.2 E(85289): 0
Smith-Waterman score: 9628; 99.9% identity (99.9% similar) in 1442 aa overlap (137-1578:12-1453)
110 120 130 140 150 160
pF1KSD PAEDLSWERAVDILREAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
::::::::::::::::::::::::::::::
XP_016 MASALPGQLGPGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
10 20 30 40
170 180 190 200 210 220
pF1KSD ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
50 60 70 80 90 100
230 240 250 260 270 280
pF1KSD EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
110 120 130 140 150 160
290 300 310 320 330 340
pF1KSD SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
170 180 190 200 210 220
350 360 370 380 390 400
pF1KSD RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
230 240 250 260 270 280
410 420 430 440 450 460
pF1KSD LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
290 300 310 320 330 340
470 480 490 500 510 520
pF1KSD KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
350 360 370 380 390 400
530 540 550 560 570 580
pF1KSD EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
410 420 430 440 450 460
590 600 610 620 630 640
pF1KSD SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
470 480 490 500 510 520
650 660 670 680 690 700
pF1KSD RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
530 540 550 560 570 580
710 720 730 740 750 760
pF1KSD YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
590 600 610 620 630 640
770 780 790 800 810 820
pF1KSD SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
650 660 670 680 690 700
830 840 850 860 870 880
pF1KSD GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
710 720 730 740 750 760
890 900 910 920 930 940
pF1KSD LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
770 780 790 800 810 820
950 960 970 980 990 1000
pF1KSD RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
830 840 850 860 870 880
1010 1020 1030 1040 1050 1060
pF1KSD EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
890 900 910 920 930 940
1070 1080 1090 1100 1110 1120
pF1KSD TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
950 960 970 980 990 1000
1130 1140 1150 1160 1170 1180
pF1KSD EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
1010 1020 1030 1040 1050 1060
1190 1200 1210 1220 1230 1240
pF1KSD EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
1070 1080 1090 1100 1110 1120
1250 1260 1270 1280 1290 1300
pF1KSD WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEV
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
XP_016 WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEV
1130 1140 1150 1160 1170 1180
1310 1320 1330 1340 1350 1360
pF1KSD SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
1190 1200 1210 1220 1230 1240
1370 1380 1390 1400 1410 1420
pF1KSD TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
1250 1260 1270 1280 1290 1300
1430 1440 1450 1460 1470 1480
pF1KSD ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
1310 1320 1330 1340 1350 1360
1490 1500 1510 1520 1530 1540
pF1KSD QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
1370 1380 1390 1400 1410 1420
1550 1560 1570
pF1KSD HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
::::::::::::::::::::::::::::::::
XP_016 HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
1430 1440 1450
>>XP_016869970 (OMIM: 616919) PREDICTED: FERM and PDZ do (1469 aa)
initn: 9628 init1: 9628 opt: 9628 Z-score: 6768.8 bits: 1265.2 E(85289): 0
Smith-Waterman score: 9628; 99.9% identity (99.9% similar) in 1442 aa overlap (137-1578:28-1469)
110 120 130 140 150 160
pF1KSD PAEDLSWERAVDILREAEDSLSITVVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
::::::::::::::::::::::::::::::
XP_016 MAEVGVSRWFIICSRCQDIHGSRADVQGVPKSSFLTEEKRARLKTNPVKVHFAEEVL
10 20 30 40 50
170 180 190 200 210 220
pF1KSD ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISGHSQGNSLLCMPNVLKLYLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALAL
60 70 80 90 100 110
230 240 250 260 270 280
pF1KSD EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEQYSISRLHLLHEEELIQQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQ
120 130 140 150 160 170
290 300 310 320 330 340
pF1KSD SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCSDVLQERFAVEMKCSSALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLL
180 190 200 210 220 230
350 360 370 380 390 400
pF1KSD RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNMKGKDIKKAISFHMKRNQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLM
240 250 260 270 280 290
410 420 430 440 450 460
pF1KSD LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDRESYIALLVGAKYGISQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDV
300 310 320 330 340 350
470 480 490 500 510 520
pF1KSD KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDS
360 370 380 390 400 410
530 540 550 560 570 580
pF1KSD EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EESSEVDCVLEPLSDRRLVKLAPCRSLIKEEQPPGNSPTPEVARRGPSTCGASSTTDSAE
420 430 440 450 460 470
590 600 610 620 630 640
pF1KSD SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEASDSANTESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEE
480 490 500 510 520 530
650 660 670 680 690 700
pF1KSD RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSGIETSGFLCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRLDPRLYEGSHADY
540 550 560 570 580 590
710 720 730 740 750 760
pF1KSD YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSLCSSVSPASYLSDSSESTASRQGGAPPAWGQQGWTEAQPSSMLEPLALHPPLAFEDGS
600 610 620 630 640 650
770 780 790 800 810 820
pF1KSD SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDEEYYDAADKLTPPGPPSGPRDVSTAEPSATSLQNKASTSSPENSLPCGPDGRQPSRRG
660 670 680 690 700 710
830 840 850 860 870 880
pF1KSD GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVKKYAKTLRKRRSFLQTDYTSQVSFPLVPSASLESVDDVCYYDREPYLALGAPSPTVSS
720 730 740 750 760 770
890 900 910 920 930 940
pF1KSD LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDMQGEPGLLETKALGLLAPLRETKSTNPASRVMEMEPETMETKSVIDSRVSSISAIRF
780 790 800 810 820 830
950 960 970 980 990 1000
pF1KSD RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIDPNNKENSGVVPAASSSASTPHCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTI
840 850 860 870 880 890
1010 1020 1030 1040 1050 1060
pF1KSD EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLELQLEPHVQLEMGLESFCTNHIQE
900 910 920 930 940 950
1070 1080 1090 1100 1110 1120
pF1KSD TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAPKYTEPLLSPRDEPRSDECGINPGEKIASIPTKEEPQGQLSLERDREVTNKNGTNVFQ
960 970 980 990 1000 1010
1130 1140 1150 1160 1170 1180
pF1KSD EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EESRKDSGDSPGDVSNNVSQTLDISSPAGKIVTSLSLDAPVTGTEQIPPHPPRDPQGQSR
1020 1030 1040 1050 1060 1070
1190 1200 1210 1220 1230 1240
pF1KSD EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPPGQGCQAQEQKLFVELDLDPDFFLGKQTVSPAVPPEGIKAEAPNHVTGQDIAPRDSPE
1080 1090 1100 1110 1120 1130
1250 1260 1270 1280 1290 1300
pF1KSD WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEV
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
XP_016 WVCFNPEPSLPEPLPCPQEDPHLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEV
1140 1150 1160 1170 1180 1190
1310 1320 1330 1340 1350 1360
pF1KSD SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SASLRVATSLGFAGMNEMVAPRIGMDQCSCQFSYATCFRGPQPETEEEDRDLEAHPMAPL
1200 1210 1220 1230 1240 1250
1370 1380 1390 1400 1410 1420
pF1KSD TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSPPSAGSPVVLPWRPARAHSCTTAPLSRKSHIWPEYCSRALRQLKATPASTPEGFIQLM
1260 1270 1280 1290 1300 1310
1430 1440 1450 1460 1470 1480
pF1KSD ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESLLELQDILETSWGVGNKHPPEKCTWHFTESRSRLCMGSQKLLSSCRHVIRMDQSPEEM
1320 1330 1340 1350 1360 1370
1490 1500 1510 1520 1530 1540
pF1KSD QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGAVRDTFQHLVQLAGLCFQFTDCSRCSARHREAAGNLRDVVYTYHQFIEAAKSTCERGY
1380 1390 1400 1410 1420 1430
1550 1560 1570
pF1KSD HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
::::::::::::::::::::::::::::::::
XP_016 HDLSVKLLARQCTALTAAVFCLTQKFRASTAL
1440 1450 1460
>>XP_016885475 (OMIM: 300830,300838,300983) PREDICTED: F (1319 aa)
initn: 927 init1: 557 opt: 1515 Z-score: 1070.5 bits: 210.7 E(85289): 6.9e-53
Smith-Waterman score: 1538; 30.3% identity (58.9% similar) in 1295 aa overlap (41-1257:59-1289)
20 30 40 50 60 70
pF1KSD TRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKIDKDTLLQDYG
: : . : . :. . :.. .: .: .:
XP_016 SQVPPYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVL-GFG
30 40 50 60 70 80
80 90 100 110 120 130
pF1KSD FHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDILREAEDSLSIT
: . :..: .:: :: ..:::.:::::...:.::. ::..:..: ..:. .:
XP_016 FVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLT
90 100 110 120 130 140
140 150 160 170 180
pF1KSD VVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHS----QGNSLLCMPNVLKLY
:.. :::.:.. :.::::.:::::.:.:::.:.:. . :::: ::::::.:
XP_016 VIQ-PYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVY
150 160 170 180 190 200
190 200 210 220 230 240
pF1KSD LENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQY--SISRLHLLHEEELI
:::::::.:.:. .:..::.:::..:::::..::.:.: ::.. . ..: ::::.: .
XP_016 LENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETL
210 220 230 240 250 260
250 260 270 280 290 300
pF1KSD QQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEMKCSS
::..: :: .:::::. ::::::.:::..:::::::::.:::.::.::::. :.: .
XP_016 TQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDI
270 280 290 300 310 320
310 320 330 340 350 360
pF1KSD ALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISFHMKR
:::::::.. . : ::::::::::.::.:.:. ..:..:: :.::::.: .:
XP_016 ALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKA
330 340 350 360 370 380
370 380 390 400 410 420
pF1KSD NQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGAKYGI
::::. : .: .:: : ...::..:..:. ::::.:.:::. ...: ..:::: .:::
XP_016 NQNLVPPGKK--LSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGI
390 400 410 420 430 440
430 440 450 460 470 480
pF1KSD SQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKDLACL
:.:::.: :... ::.:....:.:. : :.. :.... ::: .:::.::..: .::::
XP_016 SHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPITLLMESSDAMNLACL
450 460 470 480 490 500
490 500 510 520 530 540
pF1KSD IAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS----
::::::::: ::: ..:. : . : : :... . . . . .:. . .
XP_016 TAGYYRLLVDSRRSIFNMANKKNTA---TQETGPENKG-KHNLLGPDWNCIPQMTTFIGE
510 520 530 540 550 560
550 560 570 580 590
pF1KSD DRRLVKLAPCRSLIKEEQPPGNSPTPEVARR-----GPSTCGASSTTDSAESEASDSANT
.. .... : : . .. :. :. . :. : .. : .:: :.
XP_016 GEQEAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNAYSSDGLNQQL-SQPGEAPCEADY
570 580 590 600 610
600 610 620 630 640 650
pF1KSD ESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGF
.: . :. . . ..:.. . .. ... .:. ::. .: ..:. : :.
XP_016 RSLAQRSLLTLSGPETLKKAQ-ESPRGAKVSFI-FGDFALDDGISPP---------TLGY
620 630 640 650 660
660 670 680 690 700
pF1KSD LCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRL----------DPRLYEGSHAD
::: . . . .. .. . .. . .:: ... : . ......
XP_016 ETLLDEGPEMLEKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIGDVKSFQAAEGI
670 680 690 700 710 720
710 720 730 740 750 760
pF1KSD YYSLCSSVSPASYLSDSSES--TASRQGGAPPAWGQQGWTEAQPSS--MLEPLALHPPLA
: .. : .:. . .. .. . .: . . . :: ... .: ::
XP_016 EEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPP--
730 740 750 760 770 780
770 780 790 800
pF1KSD FEDGSSDEEYYDAADKLTPPGPPSGPRDVSTAEPS-------------ATSLQNKASTSS
: ...... . ... .:: : :: : : : ..:::: :
XP_016 -EGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVS
790 800 810 820 830 840
810 820 830 840 850 860
pF1KSD PENSLPCGPDGRQPSRRGGVKKYAKTLRKRRSF-----LQTDYTSQVSF--PLVPSASLE
...: . .:. ..: . ..:: ... ::. .: :.. : .: .
XP_016 LIDAVPTSAEGK--CEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSD
850 860 870 880 890 900
870 880 890 900 910 920
pF1KSD SVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETKALGLLAPLRETKSTNPASRV-
: ... . :.. . .:. : .: :. : :: : .. :::..
XP_016 SGNETNSSEMTESSELATAQKQSENLSRM-----FLATHE-GY-HPLAEEQTEFPASKTP
910 920 930 940 950
930 940 950 960
pF1KSD -----------MEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVPAASSSASTP
. .: : .:. :. . . . .....:.. :...: .. :
XP_016 AGGLPPKSSHALAARPATDLPPKVVPSK-QLLHSDHMEMEPETMETKSV----TDYFSKL
960 970 980 990 1000 1010
970 980 990 1000 1010 1020
pF1KSD HCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDPNPDRACLAS
: :: . . .. : :.. : .: :: : .:... . ..: . . ::
XP_016 HM---GSVAYSCTSKRKSKL----ADGEGKAP--P---NGNTTGKKQQGTKTAEMEEEAS
1020 1030 1040 1050
1030 1040 1050 1060 1070 1080
pF1KSD NPGLNNVSQGDTLELQ---LEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRDEPRSDE
. ...::. :. .:. :: .. .. . . . : : . . ::..
XP_016 GK-FGTVSSRDSQHLSTFNLE-RTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASG
1060 1070 1080 1090 1100 1110
1090 1100 1110 1120 1130 1140
pF1KSD CGINPGE-KIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDVSNNVS
: .: : . : : .:. . :: .:. : : :: :.: :.....
XP_016 LGAREAEGKEEGAPDGETSDGSGLGQGDRFLTD-----VTCASSAKDL-DNPEDADSSTC
1120 1130 1140 1150 1160 1170
1150 1160 1170 1180 1190 1200
pF1KSD QTLDISSPAGKIVTSLSLD---APVTGTEQIPPHPP-RDPQGQSREPP-GQGCQAQEQKL
. . : . :. : : : .. : : .. ::.: . : : ...
XP_016 DHPSKLPEADESVARLC-DYHLAKRMSSLQSEGHFSLQSSQGSSVDAGCGTGSSGSACAT
1180 1190 1200 1210 1220 1230
1210 1220 1230 1240 1250
pF1KSD FVELDLDPDFFLGKQTVSPA-------VPPEGIKAEAPNH-VTGQDIAPRDSPEWVCFNP
:: : :. :::. . : .: : ::: .: ... :. : .: :
XP_016 PVESPLCPS--LGKHLIPDASGKGVNYIPSEERAPGLPNHGATFKELHPQ--TEGMC--P
1240 1250 1260 1270 1280
1260 1270 1280 1290 1300 1310
pF1KSD EPSLPEPLPCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRV
. ..:
XP_016 RMTVPALHTAINTEPLFGTLRDGCHRLPKIKETTV
1290 1300 1310
>>NP_055543 (OMIM: 300830,300838,300983) FERM and PDZ do (1322 aa)
initn: 927 init1: 557 opt: 1515 Z-score: 1070.5 bits: 210.7 E(85289): 6.9e-53
Smith-Waterman score: 1538; 30.3% identity (58.9% similar) in 1295 aa overlap (41-1257:62-1292)
20 30 40 50 60 70
pF1KSD TRKAHRIEQMVARWLRRSRDSSARAKVAAADGPARNPTQTLIPVRHTVKIDKDTLLQDYG
: : . : . :. . :.. .: .: .:
NP_055 SQVPPYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVL-GFG
40 50 60 70 80 90
80 90 100 110 120 130
pF1KSD FHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDILREAEDSLSIT
: . :..: .:: :: ..:::.:::::...:.::. ::..:..: ..:. .:
NP_055 FVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLT
100 110 120 130 140 150
140 150 160 170 180
pF1KSD VVRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISGHS----QGNSLLCMPNVLKLY
:.. :::.:.. :.::::.:::::.:.:::.:.:. . :::: ::::::.:
NP_055 VIQ-PYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVY
160 170 180 190 200
190 200 210 220 230 240
pF1KSD LENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQY--SISRLHLLHEEELI
:::::::.:.:. .:..::.:::..:::::..::.:.: ::.. . ..: ::::.: .
NP_055 LENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETL
210 220 230 240 250 260
250 260 270 280 290 300
pF1KSD QQVVEREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEMKCSS
::..: :: .:::::. ::::::.:::..:::::::::.:::.::.::::. :.: .
NP_055 TQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDI
270 280 290 300 310 320
310 320 330 340 350 360
pF1KSD ALRLAALHIQERIYACAQPQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISFHMKR
:::::::.. . : ::::::::::.::.:.:. ..:..:: :.::::.: .:
NP_055 ALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKA
330 340 350 360 370 380
370 380 390 400 410 420
pF1KSD NQNLLEPRQKQLISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESYIALLVGAKYGI
::::. : .: .:: : ...::..:..:. ::::.:.:::. ...: ..:::: .:::
NP_055 NQNLVPPGKK--LSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGI
390 400 410 420 430 440
430 440 450 460 470 480
pF1KSD SQVINSKLNIMSTLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKDLACL
:.:::.: :... ::.:....:.:. : :.. :.... ::: .:::.::..: .::::
NP_055 SHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPITLLMESSDAMNLACL
450 460 470 480 490 500
490 500 510 520 530 540
pF1KSD IAGYYRLLVDPVTSIFLWPGNKQQAHRVSAEEGYESRACSDSEESSEVDCVLEPLS----
::::::::: ::: ..:. : . : : :... . . . . .:. . .
NP_055 TAGYYRLLVDSRRSIFNMANKKNTA---TQETGPENKG-KHNLLGPDWNCIPQMTTFIGE
510 520 530 540 550 560
550 560 570 580 590
pF1KSD DRRLVKLAPCRSLIKEEQPPGNSPTPEVARR-----GPSTCGASSTTDSAESEASDSANT
.. .... : : . .. :. :. . :. : .. : .:: :.
NP_055 GEQEAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNAYSSDGLNQQL-SQPGEAPCEADY
570 580 590 600 610 620
600 610 620 630 640 650
pF1KSD ESRGYRTSGSSESMDALEEDDLDTCSSSRSTFFHFGSPGLAESIDSDSQEERSGIETSGF
.: . :. . . ..:.. . .. ... .:. ::. .: ..:. : :.
NP_055 RSLAQRSLLTLSGPETLKKAQ-ESPRGAKVSFI-FGDFALDDGISPP---------TLGY
630 640 650 660 670
660 670 680 690 700
pF1KSD LCLLDLAQRANPQCQKTEFSESAALETFGWAPELSTVRL----------DPRLYEGSHAD
::: . . . .. .. . .. . .:: ... : . ......
NP_055 ETLLDEGPEMLEKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIGDVKSFQAAEGI
680 690 700 710 720 730
710 720 730 740 750 760
pF1KSD YYSLCSSVSPASYLSDSSES--TASRQGGAPPAWGQQGWTEAQPSS--MLEPLALHPPLA
: .. : .:. . .. .. . .: . . . :: ... .: ::
NP_055 EEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPP--
740 750 760 770 780
770 780 790 800
pF1KSD FEDGSSDEEYYDAADKLTPPGPPSGPRDVSTAEPS-------------ATSLQNKASTSS
: ...... . ... .:: : :: : : : ..:::: :
NP_055 -EGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVS
790 800 810 820 830 840
810 820 830 840 850 860
pF1KSD PENSLPCGPDGRQPSRRGGVKKYAKTLRKRRSF-----LQTDYTSQVSF--PLVPSASLE
...: . .:. ..: . ..:: ... ::. .: :.. : .: .
NP_055 LIDAVPTSAEGK--CEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSD
850 860 870 880 890 900
870 880 890 900 910 920
pF1KSD SVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLETKALGLLAPLRETKSTNPASRV-
: ... . :.. . .:. : .: :. : :: : .. :::..
NP_055 SGNETNSSEMTESSELATAQKQSENLSRM-----FLATHE-GY-HPLAEEQTEFPASKTP
910 920 930 940 950
930 940 950 960
pF1KSD -----------MEMEPETMETKSVIDSRVSSISAIRFRIDPNNKENSGVVPAASSSASTP
. .: : .:. :. . . . .....:.. :...: .. :
NP_055 AGGLPPKSSHALAARPATDLPPKVVPSK-QLLHSDHMEMEPETMETKSV----TDYFSKL
960 970 980 990 1000 1010
970 980 990 1000 1010 1020
pF1KSD HCSNPGSSGPDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDPNPDRACLAS
: :: . . .. : :.. : .: :: : .:... . ..: . . ::
NP_055 HM---GSVAYSCTSKRKSKL----ADGEGKAP--P---NGNTTGKKQQGTKTAEMEEEAS
1020 1030 1040 1050 1060
1030 1040 1050 1060 1070 1080
pF1KSD NPGLNNVSQGDTLELQ---LEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRDEPRSDE
. ...::. :. .:. :: .. .. . . . : : . . ::..
NP_055 GK-FGTVSSRDSQHLSTFNLE-RTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASG
1070 1080 1090 1100 1110 1120
1090 1100 1110 1120 1130 1140
pF1KSD CGINPGE-KIASIPTKEEPQGQLSLERDREVTNKNGTNVFQEESRKDSGDSPGDVSNNVS
: .: : . : : .:. . :: .:. : : :: :.: :.....
NP_055 LGAREAEGKEEGAPDGETSDGSGLGQGDRFLTD-----VTCASSAKDL-DNPEDADSSTC
1130 1140 1150 1160 1170
1150 1160 1170 1180 1190 1200
pF1KSD QTLDISSPAGKIVTSLSLD---APVTGTEQIPPHPP-RDPQGQSREPP-GQGCQAQEQKL
. . : . :. : : : .. : : .. ::.: . : : ...
NP_055 DHPSKLPEADESVARLC-DYHLAKRMSSLQSEGHFSLQSSQGSSVDAGCGTGSSGSACAT
1180 1190 1200 1210 1220 1230
1210 1220 1230 1240 1250
pF1KSD FVELDLDPDFFLGKQTVSPA-------VPPEGIKAEAPNH-VTGQDIAPRDSPEWVCFNP
:: : :. :::. . : .: : ::: .: ... :. : .: :
NP_055 PVESPLCPS--LGKHLIPDASGKGVNYIPSEERAPGLPNHGATFKELHPQ--TEGMC--P
1240 1250 1260 1270 1280
1260 1270 1280 1290 1300 1310
pF1KSD EPSLPEPLPCPQEDPHLETSNHCLLLEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRV
. ..:
NP_055 RMTVPALHTAINTEPLFGTLRDGCHRLPKIKETTV
1290 1300 1310 1320
1578 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 04:28:51 2016 done: Thu Nov 3 04:28:53 2016
Total Scan time: 17.220 Total Display time: 0.930
Function used was FASTA [36.3.4 Apr, 2011]