Result of FASTA (omim) for
pF1KSDA0969
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0969, 1048 aa
1>>>pF1KSDA0969 1048 - 1048 aa - 1048 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.8076+/-0.000406; mu= -6.6174+/- 0.025
mean_var=375.1658+/-75.508, 0's: 0 Z-trim(122.8): 150 B-trim: 0 in 0/59
Lambda= 0.066216
statistics sampled from 41450 (41603) to 41450 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.771), E-opt: 0.2 (0.488), width: 16
Scan time: 17.840
The best scores are: opt bits E(85289)
XP_005245025 (OMIM: 607771) PREDICTED: pleckstrin (1048) 7104 693.4 1.8e-198
NP_055750 (OMIM: 607771) pleckstrin homology domai (1048) 7104 693.4 1.8e-198
XP_005245024 (OMIM: 607771) PREDICTED: pleckstrin (1069) 6241 610.9 1.2e-173
XP_006711282 (OMIM: 607771) PREDICTED: pleckstrin (1119) 4150 411.2 1.7e-113
XP_005245023 (OMIM: 607771) PREDICTED: pleckstrin (1173) 3619 360.5 3.2e-98
XP_016856179 (OMIM: 607771) PREDICTED: pleckstrin (1215) 3619 360.5 3.3e-98
XP_016856178 (OMIM: 607771) PREDICTED: pleckstrin (1128) 3618 360.4 3.3e-98
XP_006711280 (OMIM: 607771) PREDICTED: pleckstrin (1143) 2768 279.2 9.3e-74
XP_016856176 (OMIM: 607771) PREDICTED: pleckstrin (1171) 2768 279.2 9.5e-74
XP_006711277 (OMIM: 607771) PREDICTED: pleckstrin (1172) 2768 279.2 9.5e-74
XP_011507597 (OMIM: 607771) PREDICTED: pleckstrin (1192) 2768 279.2 9.6e-74
XP_011507606 (OMIM: 607771) PREDICTED: pleckstrin (1193) 2768 279.2 9.6e-74
XP_006711285 (OMIM: 607771) PREDICTED: pleckstrin (1193) 2768 279.2 9.6e-74
XP_006711284 (OMIM: 607771) PREDICTED: pleckstrin (1193) 2768 279.2 9.6e-74
XP_011507603 (OMIM: 607771) PREDICTED: pleckstrin (1235) 2768 279.2 9.9e-74
XP_011507601 (OMIM: 607771) PREDICTED: pleckstrin (1243) 2768 279.2 9.9e-74
XP_011507600 (OMIM: 607771) PREDICTED: pleckstrin (1245) 2768 279.2 1e-73
XP_006711278 (OMIM: 607771) PREDICTED: pleckstrin (1148) 2767 279.1 1e-73
XP_011507599 (OMIM: 607771) PREDICTED: pleckstrin (1297) 2768 279.2 1e-73
XP_006711275 (OMIM: 607771) PREDICTED: pleckstrin (1301) 2768 279.2 1e-73
XP_011507598 (OMIM: 607771) PREDICTED: pleckstrin (1166) 2751 277.6 2.9e-73
XP_016856177 (OMIM: 607771) PREDICTED: pleckstrin (1154) 2736 276.1 7.8e-73
XP_006711276 (OMIM: 607771) PREDICTED: pleckstrin (1175) 2736 276.1 7.9e-73
XP_016856181 (OMIM: 607771) PREDICTED: pleckstrin (1021) 2597 262.8 7.1e-69
XP_016856180 (OMIM: 607771) PREDICTED: pleckstrin (1021) 2597 262.8 7.1e-69
NP_061885 (OMIM: 607770) pleckstrin homology domai (1116) 1000 110.3 6.4e-23
XP_005253457 (OMIM: 607770) PREDICTED: pleckstrin (1179) 994 109.7 9.9e-23
XP_006719156 (OMIM: 607770) PREDICTED: pleckstrin (1151) 978 108.2 2.8e-22
XP_016874988 (OMIM: 607770) PREDICTED: pleckstrin ( 812) 969 107.2 3.9e-22
NP_001243399 (OMIM: 607770) pleckstrin homology do (1282) 860 96.9 7.5e-19
XP_016874990 (OMIM: 607770) PREDICTED: pleckstrin ( 628) 619 73.7 3.7e-12
XP_016874989 (OMIM: 607770) PREDICTED: pleckstrin ( 685) 619 73.7 3.9e-12
XP_016874987 (OMIM: 607770) PREDICTED: pleckstrin (1093) 619 73.9 5.7e-12
NP_001243716 (OMIM: 607770) pleckstrin homology do (1098) 619 73.9 5.7e-12
XP_016874986 (OMIM: 607770) PREDICTED: pleckstrin (1168) 619 73.9 6e-12
XP_011519019 (OMIM: 607770) PREDICTED: pleckstrin (1174) 619 73.9 6e-12
NP_001137293 (OMIM: 607770) pleckstrin homology do (1174) 619 73.9 6e-12
XP_006719154 (OMIM: 607770) PREDICTED: pleckstrin (1197) 619 73.9 6.1e-12
XP_016874985 (OMIM: 607770) PREDICTED: pleckstrin (1208) 619 73.9 6.1e-12
XP_011519018 (OMIM: 607770) PREDICTED: pleckstrin (1213) 619 73.9 6.1e-12
XP_011519017 (OMIM: 607770) PREDICTED: pleckstrin (1237) 619 73.9 6.2e-12
XP_011519016 (OMIM: 607770) PREDICTED: pleckstrin (1264) 619 73.9 6.3e-12
XP_016874984 (OMIM: 607770) PREDICTED: pleckstrin (1271) 619 73.9 6.4e-12
XP_006719159 (OMIM: 607770) PREDICTED: pleckstrin (1276) 619 73.9 6.4e-12
NP_778228 (OMIM: 612686) pleckstrin homology domai (1121) 606 72.6 1.4e-11
NP_001316560 (OMIM: 612686) pleckstrin homology do (1122) 606 72.6 1.4e-11
XP_016872731 (OMIM: 612686) PREDICTED: pleckstrin (1149) 606 72.6 1.4e-11
XP_016872730 (OMIM: 612686) PREDICTED: pleckstrin (1189) 606 72.7 1.4e-11
XP_016872729 (OMIM: 612686) PREDICTED: pleckstrin (1207) 606 72.7 1.4e-11
NP_001316559 (OMIM: 612686) pleckstrin homology do (1271) 606 72.7 1.5e-11
>>XP_005245025 (OMIM: 607771) PREDICTED: pleckstrin homo (1048 aa)
initn: 7104 init1: 7104 opt: 7104 Z-score: 3684.3 bits: 693.4 E(85289): 1.8e-198
Smith-Waterman score: 7104; 99.8% identity (100.0% similar) in 1048 aa overlap (1-1048:1-1048)
10 20 30 40 50 60
pF1KSD MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAIAFGKRSHSMKRNPNAPV
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_005 MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD SENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD PRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD DYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD TVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSAR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD FERLPPRSEDIYADPAAYVMRRSISSPKVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FERLPPRSEDIYADPAAYVMRRSISSPKVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD NKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD VELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVME
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD GLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD GSNEPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEKQAALNKVGVVPPRTKSPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSNEPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEKQAALNKVGVVPPRTKSPTD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD DEVTPSAVVRRNASGLTNGLSSQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMKEKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
XP_005 DEVTPSAVVRRNASGLTNGLSSQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD RSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD RKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD SSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPT
970 980 990 1000 1010 1020
1030 1040
pF1KSD SPASPAPPANPLSSESPRGADSSYTMRV
::::::::::::::::::::::::::::
XP_005 SPASPAPPANPLSSESPRGADSSYTMRV
1030 1040
>>NP_055750 (OMIM: 607771) pleckstrin homology domain-co (1048 aa)
initn: 7104 init1: 7104 opt: 7104 Z-score: 3684.3 bits: 693.4 E(85289): 1.8e-198
Smith-Waterman score: 7104; 99.8% identity (100.0% similar) in 1048 aa overlap (1-1048:1-1048)
10 20 30 40 50 60
pF1KSD MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAIAFGKRSHSMKRNPNAPV
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
NP_055 MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD SENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD PRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD DYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD TVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSAR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD FERLPPRSEDIYADPAAYVMRRSISSPKVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FERLPPRSEDIYADPAAYVMRRSISSPKVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD NKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD VELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVME
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD GLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD GSNEPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEKQAALNKVGVVPPRTKSPTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GSNEPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEKQAALNKVGVVPPRTKSPTD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD DEVTPSAVVRRNASGLTNGLSSQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMKEKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
NP_055 DEVTPSAVVRRNASGLTNGLSSQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD RSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPREEIARL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD RKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAK
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD SSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCATPSPPT
970 980 990 1000 1010 1020
1030 1040
pF1KSD SPASPAPPANPLSSESPRGADSSYTMRV
::::::::::::::::::::::::::::
NP_055 SPASPAPPANPLSSESPRGADSSYTMRV
1030 1040
>>XP_005245024 (OMIM: 607771) PREDICTED: pleckstrin homo (1069 aa)
initn: 5559 init1: 4641 opt: 6241 Z-score: 3238.6 bits: 610.9 E(85289): 1.2e-173
Smith-Waterman score: 7042; 97.8% identity (98.0% similar) in 1069 aa overlap (1-1048:1-1069)
10 20 30 40 50 60
pF1KSD MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAIAFGKRSHSMKRNPNAPV
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_005 MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
70 80 90 100 110 120
130 140 150 160
pF1KSD SRKHTFK--------------------AEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQ
::::::: :::::::::::::::::::::::::::::::::
XP_005 SRKHTFKVTVCWVDEAEASSTRCLSPQAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQ
130 140 150 160 170 180
170 180 190 200 210 220
pF1KSD IPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAE
190 200 210 220 230 240
230 240 250 260 270 280
pF1KSD RRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRP
250 260 270 280 290 300
290 300 310 320 330 340
pF1KSD GSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRF
310 320 330 340 350 360
350 360 370 380 390 400
pF1KSD YPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KSD GPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSP
430 440 450 460 470 480
470 480 490 500 510 520
pF1KSD SQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPKVPPYPEVFRDSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPKVPPYPEVFRDSL
490 500 510 520 530 540
530 540 550 560 570 580
pF1KSD HTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPA
550 560 570 580 590 600
590 600 610 620 630 640
pF1KSD YPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQ
610 620 630 640 650 660
650 660 670 680 690 700
pF1KSD NEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASL
670 680 690 700 710 720
710 720 730 740 750 760
pF1KSD TSPLSPFSLVSGSQGSPTKPGSNEPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSPLSPFSLVSGSQGSPTKPGSNEPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAE
730 740 750 760 770 780
770 780 790 800 810
pF1KSD KQAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQ-ERPKSAVFPGEGKVKM
::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
XP_005 KQAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQQERPKSAVFPGEGKVKM
790 800 810 820 830 840
820 830 840 850 860 870
pF1KSD SVEEQIDRMRRHQSGSMKEKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAA
:::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::
XP_005 SVEEQIDRMRRHQSGSMREKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAA
850 860 870 880 890 900
880 890 900 910 920 930
pF1KSD LRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPL
910 920 930 940 950 960
940 950 960 970 980 990
pF1KSD SPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALA
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040
pF1KSD TEASRRGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYTMRV
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TEASRRGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYTMRV
1030 1040 1050 1060
>>XP_006711282 (OMIM: 607771) PREDICTED: pleckstrin homo (1119 aa)
initn: 5739 init1: 4130 opt: 4150 Z-score: 2158.8 bits: 411.2 E(85289): 1.7e-113
Smith-Waterman score: 6809; 93.4% identity (93.5% similar) in 1100 aa overlap (1-1029:1-1100)
10 20 30 40 50 60
pF1KSD MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAIAFGKRSHSMKRNPNAPV
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_006 MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
70 80 90 100 110 120
130 140 150 160
pF1KSD SRKHTFK--------------------AEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQ
::::::: :::::::::::::::::::::::::::::::::
XP_006 SRKHTFKVTVCWVDEAEASSTRCLSPQAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQ
130 140 150 160 170 180
170 180 190 200 210 220
pF1KSD IPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAE
190 200 210 220 230 240
230 240 250 260 270 280
pF1KSD RRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRP
250 260 270 280 290 300
290 300 310 320 330 340
pF1KSD GSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRF
310 320 330 340 350 360
350 360 370 380 390 400
pF1KSD YPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KSD GPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSP
430 440 450 460 470 480
470 480 490 500 510 520
pF1KSD SQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPKVPPYPEVFRDSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPKVPPYPEVFRDSL
490 500 510 520 530 540
530 540 550 560 570 580
pF1KSD HTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPA
550 560 570 580 590 600
590 600 610 620 630 640
pF1KSD YPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQ
610 620 630 640 650 660
650 660 670 680 690 700
pF1KSD NEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASL
670 680 690 700 710 720
710 720
pF1KSD TSPLSPFSLVSGSQGSPTKPGSNE------------------------------------
::::::::::::::::::::::::
XP_006 TSPLSPFSLVSGSQGSPTKPGSNEEPGPPRPPLPKAYVPLESPPAVPPLPSESRFWPYPS
730 740 750 760 770 780
730 740 750 760 770
pF1KSD --------------PKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEKQAALNKVGV
::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPSWHRSGETARGQPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEKQAALNKVGV
790 800 810 820 830 840
780 790 800 810 820
pF1KSD VPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQ-ERPKSAVFPGEGKVKMSVEEQIDRMR
::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_006 VPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQQERPKSAVFPGEGKVKMSVEEQIDRMR
850 860 870 880 890 900
830 840 850 860 870 880
pF1KSD RHQSGSMKEKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHA
:::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RHQSGSMREKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHA
910 920 930 940 950 960
890 900 910 920 930 940
pF1KSD YETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQK
970 980 990 1000 1010 1020
950 960 970 980 990 1000
pF1KSD KVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRML
1030 1040 1050 1060 1070 1080
1010 1020 1030 1040
pF1KSD SVQCATPSPPTSPASPAPPANPLSSESPRGADSSYTMRV
::::::::::::::::::::
XP_006 SVQCATPSPPTSPASPAPPANPLSSESPRGADSSYTMRV
1090 1100 1110
>>XP_005245023 (OMIM: 607771) PREDICTED: pleckstrin homo (1173 aa)
initn: 5249 init1: 3576 opt: 3619 Z-score: 1884.4 bits: 360.5 E(85289): 3.2e-98
Smith-Waterman score: 6218; 88.2% identity (88.4% similar) in 1080 aa overlap (1-955:1-1080)
10 20 30 40 50 60
pF1KSD MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAIAFGKRSHSMKRNPNAPV
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_005 MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD SENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD PRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD DYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD TVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSAR
430 440 450 460 470 480
490 500
pF1KSD FERLPPRSEDIYADPAAYVMRRSISSPK--------------------------------
::::::::::::::::::::::::::::
XP_005 FERLPPRSEDIYADPAAYVMRRSISSPKYDYLGDRRPVPAGLFPYNYPPSPTVHDKMDEL
490 500 510 520 530 540
510 520
pF1KSD ------------------------------------------VPPYPEVFRDSLHTYKLN
::::::::::::::::::
XP_005 LDLQLQRNLEYLDQQMSESETLISMVNRMVENSSPRSQLFMQVPPYPEVFRDSLHTYKLN
550 560 570 580 590 600
530 540 550 560 570 580
pF1KSD EQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTHQELEMFGSQPAYPEKLR
610 620 630 640 650 660
590 600 610 620 630 640
pF1KSD HKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQNEVLNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHDDLWEQLNLDTQNEVLNR
670 680 690 700 710 720
650 660 670 680 690 700
pF1KSD QIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASLTSPLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSPASPLSSASLTSPLSP
730 740 750 760 770 780
710 720
pF1KSD FSLVSGSQGSPTKPGSNE------------------------------------------
::::::::::::::::::
XP_005 FSLVSGSQGSPTKPGSNEEPGPPRPPLPKAYVPLESPPAVPPLPSESRFWPYPSSPSWHR
790 800 810 820 830 840
730 740 750 760 770
pF1KSD --------PKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEKQAALNKVGVVPPRTK
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGETARGQPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEKQAALNKVGVVPPRTK
850 860 870 880 890 900
780 790 800 810 820 830
pF1KSD SPTDDEVTPSAVVRRNASGLTNGLSSQ-ERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGS
::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::
XP_005 SPTDDEVTPSAVVRRNASGLTNGLSSQQERPKSAVFPGEGKVKMSVEEQIDRMRRHQSGS
910 920 930 940 950 960
840 850 860 870 880 890
pF1KSD MKEKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPRE
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MREKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAALRAEEPGGHAYETPRE
970 980 990 1000 1010 1020
900 910 920 930 940 950
pF1KSD EIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLSPEELKEKQKKVERIK
1030 1040 1050 1060 1070 1080
960 970 980 990 1000 1010
pF1KSD TLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCAT
XP_005 TLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALATEASRRGRMLSVQCAT
1090 1100 1110 1120 1130 1140
>--
initn: 606 init1: 606 opt: 606 Z-score: 328.8 bits: 72.6 E(85289): 1.4e-11
Smith-Waterman score: 606; 100.0% identity (100.0% similar) in 93 aa overlap (956-1048:1081-1173)
930 940 950 960 970 980
pF1KSD IPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQL
::::::::::::::::::::::::::::::
XP_005 IPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQL
1060 1070 1080 1090 1100 1110
990 1000 1010 1020 1030 1040
pF1KSD QEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYT
1120 1130 1140 1150 1160 1170
pF1KSD MRV
:::
XP_005 MRV
>>XP_016856179 (OMIM: 607771) PREDICTED: pleckstrin homo (1215 aa)
initn: 5249 init1: 3576 opt: 3619 Z-score: 1884.1 bits: 360.5 E(85289): 3.3e-98
Smith-Waterman score: 6218; 88.2% identity (88.4% similar) in 1080 aa overlap (1-955:43-1122)
10 20 30
pF1KSD MSNKTGGKRPATTNSDIPNHNMVSEVPPER
::::::::::::::::::::::::::::::
XP_016 NERRNTFLHPVTGQVPEENKKFDLKISTLDMSNKTGGKRPATTNSDIPNHNMVSEVPPER
20 30 40 50 60 70
40 50 60 70 80 90
pF1KSD PSVRATRTARKAIAFGKRSHSMKRNPNAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLF
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSVRATRTARKAVAFGKRSHSMKRNPNAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLF
80 90 100 110 120 130
100 110 120 130 140 150
pF1KSD YYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YYKDEKEESILGSIPLLSFRVAAVQPSDNISRKHTFKAEHAGVRTYFFSAESPEEQEAWI
140 150 160 170 180 190
160 170 180 190 200 210
pF1KSD QAMGEAARVQIPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QAMGEAARVQIPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGE
200 210 220 230 240 250
220 230 240 250 260 270
pF1KSD GDGRGCEKAERRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDGRGCEKAERRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPN
260 270 280 290 300 310
280 290 300 310 320 330
pF1KSD GWQYHSPSRPGSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GWQYHSPSRPGSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPP
320 330 340 350 360 370
340 350 360 370 380 390
pF1KSD PEDLRSPSRFYPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEDLRSPSRFYPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALE
380 390 400 410 420 430
400 410 420 430 440 450
pF1KSD DKRHAFRNGGGPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKRHAFRNGGGPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQ
440 450 460 470 480 490
460 470 480 490 500
pF1KSD PRSHSVPRSPSQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPK--
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRSHSVPRSPSQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPKYD
500 510 520 530 540 550
pF1KSD ------------------------------------------------------------
XP_016 YLGDRRPVPAGLFPYNYPPSPTVHDKMDELLDLQLQRNLEYLDQQMSESETLISMVNRMV
560 570 580 590 600 610
510 520 530 540 550
pF1KSD ------------VPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRA
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENSSPRSQLFMQVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRA
620 630 640 650 660 670
560 570 580 590 600 610
pF1KSD EKESLESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKESLESALMGTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIE
680 690 700 710 720 730
620 630 640 650 660 670
pF1KSD YEHLESEVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YEHLESEVSALHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKH
740 750 760 770 780 790
680 690 700 710 720
pF1KSD RGGLGPSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNE------------
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGGLGPSATYSSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEEPGPPRPPLPKA
800 810 820 830 840 850
730 740
pF1KSD --------------------------------------PKANYEQSKKDPHQTLPLDTPR
::::::::::::::::::::::
XP_016 YVPLESPPAVPPLPSESRFWPYPSSPSWHRSGETARGQPKANYEQSKKDPHQTLPLDTPR
860 870 880 890 900 910
750 760 770 780 790 800
pF1KSD DISLVPTRQEVEAEKQAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQ-ER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
XP_016 DISLVPTRQEVEAEKQAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQQER
920 930 940 950 960 970
810 820 830 840 850 860
pF1KSD PKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMKEKRRSLQLPASPAPDPSPRPAYKVVRRH
:::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::
XP_016 PKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKRRSLQLPASPAPDPSPRPAYKVVRRH
980 990 1000 1010 1020 1030
870 880 890 900 910 920
pF1KSD RSIHEVDISNLEAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSIHEVDISNLEAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVL
1040 1050 1060 1070 1080 1090
930 940 950 960 970 980
pF1KSD IPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQL
::::::::::::::::::::::::::::::
XP_016 IPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQL
1100 1110 1120 1130 1140 1150
>--
initn: 606 init1: 606 opt: 606 Z-score: 328.6 bits: 72.7 E(85289): 1.5e-11
Smith-Waterman score: 606; 100.0% identity (100.0% similar) in 93 aa overlap (956-1048:1123-1215)
930 940 950 960 970 980
pF1KSD IPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQL
::::::::::::::::::::::::::::::
XP_016 IPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQL
1100 1110 1120 1130 1140 1150
990 1000 1010 1020 1030 1040
pF1KSD QEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYT
1160 1170 1180 1190 1200 1210
pF1KSD MRV
:::
XP_016 MRV
>>XP_016856178 (OMIM: 607771) PREDICTED: pleckstrin homo (1128 aa)
initn: 5249 init1: 3576 opt: 3618 Z-score: 1884.1 bits: 360.4 E(85289): 3.3e-98
Smith-Waterman score: 6589; 92.4% identity (92.6% similar) in 1080 aa overlap (1-1000:1-1080)
10 20 30 40 50 60
pF1KSD MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAIAFGKRSHSMKRNPNAPV
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_016 MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD SENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAERRPERPEVKKEPPVKANGLP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD AGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRPGSTAFPSQDGETGGHRRSFP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD PRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRFYPVSRRVPEYYGPYSSQYPD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD DYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGGGPAYQLREWKEPASYGRQDA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD TVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSPSQGSYSRARIYSPVRSPSAR
430 440 450 460 470 480
490 500 510
pF1KSD FERLPPRSEDIYADPAAYVMRRSISSPK-----------------------------VPP
:::::::::::::::::::::::::::: :::
XP_016 FERLPPRSEDIYADPAAYVMRRSISSPKYDYLGDRRPVPAGLFPYNYPPSPTVHDKMVPP
490 500 510 520 530 540
520 530 540 550 560 570
pF1KSD YPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTHQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALMGTHQE
550 560 570 580 590 600
580 590 600 610 620 630
pF1KSD LEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHDDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSALHDDL
610 620 630 640 650 660
640 650 660 670 680 690
pF1KSD WEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATYSSNSP
670 680 690 700 710 720
700 710 720
pF1KSD ASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNE---------------------------
:::::::::::::::::::::::::::::::::
XP_016 ASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEEPGPPRPPLPKAYVPLESPPAVPPLPS
730 740 750 760 770 780
730 740 750 760
pF1KSD -----------------------PKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEK
:::::::::::::::::::::::::::::::::::::
XP_016 ESRFWPYPSSPSWHRSGETARGQPKANYEQSKKDPHQTLPLDTPRDISLVPTRQEVEAEK
790 800 810 820 830 840
770 780 790 800 810 820
pF1KSD QAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQ-ERPKSAVFPGEGKVKMS
:::::::::::::::::::::::::::::::::::::::::: :::::::::::::::::
XP_016 QAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQQERPKSAVFPGEGKVKMS
850 860 870 880 890 900
830 840 850 860 870 880
pF1KSD VEEQIDRMRRHQSGSMKEKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAAL
::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
XP_016 VEEQIDRMRRHQSGSMREKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNLEAAL
910 920 930 940 950 960
890 900 910 920 930 940
pF1KSD RAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPDTPLS
970 980 990 1000 1010 1020
950 960 970 980 990 1000
pF1KSD PEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISCALAT
1030 1040 1050 1060 1070 1080
1010 1020 1030 1040
pF1KSD EASRRGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYTMRV
XP_016 EASRRGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYTMRV
1090 1100 1110 1120
>>XP_006711280 (OMIM: 607771) PREDICTED: pleckstrin homo (1143 aa)
initn: 4673 init1: 2724 opt: 2768 Z-score: 1445.2 bits: 279.2 E(85289): 9.3e-74
Smith-Waterman score: 6589; 91.2% identity (91.4% similar) in 1100 aa overlap (1-1005:1-1100)
10 20 30 40 50 60
pF1KSD MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAIAFGKRSHSMKRNPNAPV
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_006 MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
70 80 90 100 110 120
130 140 150 160
pF1KSD SRKHTFK--------------------AEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQ
::::::: :::::::::::::::::::::::::::::::::
XP_006 SRKHTFKVTVCWVDEAEASSTRCLSPQAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQ
130 140 150 160 170 180
170 180 190 200 210 220
pF1KSD IPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAE
190 200 210 220 230 240
230 240 250 260 270 280
pF1KSD RRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRP
250 260 270 280 290 300
290 300 310 320 330 340
pF1KSD GSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRF
310 320 330 340 350 360
350 360 370 380 390 400
pF1KSD YPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KSD GPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSP
430 440 450 460 470 480
470 480 490 500
pF1KSD SQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPK------------
::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPKYDYLGDRRPVPA
490 500 510 520 530 540
pF1KSD ------------------------------------------------------------
XP_006 GLFPYNYPPSPTVHDKMDELLDLQLQRNLEYLDQQMSESETLISMVNRMVENSSPRSQLF
550 560 570 580 590 600
510 520 530 540 550 560
pF1KSD --VPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MQVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALM
610 620 630 640 650 660
570 580 590 600 610 620
pF1KSD GTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSA
670 680 690 700 710 720
630 640 650 660 670 680
pF1KSD LHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATY
730 740 750 760 770 780
690 700 710 720 730 740
pF1KSD SSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEPKANYEQSKKDPHQTLPLDTPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEPKANYEQSKKDPHQTLPLDTPR
790 800 810 820 830 840
750 760 770 780 790 800
pF1KSD DISLVPTRQEVEAEKQAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQ-ER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
XP_006 DISLVPTRQEVEAEKQAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQQER
850 860 870 880 890 900
810 820 830 840 850 860
pF1KSD PKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMKEKRRSLQLPASPAPDPSPRPAYKVVRRH
:::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::
XP_006 PKSAVFPGEGKVKMSVEEQIDRMRRHQSGSMREKRRSLQLPASPAPDPSPRPAYKVVRRH
910 920 930 940 950 960
870 880 890 900 910 920
pF1KSD RSIHEVDISNLEAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSIHEVDISNLEAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVL
970 980 990 1000 1010 1020
930 940 950 960 970 980
pF1KSD IPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQL
1030 1040 1050 1060 1070 1080
990 1000 1010 1020 1030 1040
pF1KSD QEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYT
::::::::::::::::::::
XP_006 QEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYT
1090 1100 1110 1120 1130 1140
>>XP_016856176 (OMIM: 607771) PREDICTED: pleckstrin homo (1171 aa)
initn: 4625 init1: 2724 opt: 2768 Z-score: 1445.0 bits: 279.2 E(85289): 9.5e-74
Smith-Waterman score: 6185; 86.7% identity (86.9% similar) in 1100 aa overlap (1-956:1-1100)
10 20 30 40 50 60
pF1KSD MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAIAFGKRSHSMKRNPNAPV
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_016 MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
70 80 90 100 110 120
130 140 150 160
pF1KSD SRKHTFK--------------------AEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQ
::::::: :::::::::::::::::::::::::::::::::
XP_016 SRKHTFKVTVCWVDEAEASSTRCLSPQAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQ
130 140 150 160 170 180
170 180 190 200 210 220
pF1KSD IPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAE
190 200 210 220 230 240
230 240 250 260 270 280
pF1KSD RRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRP
250 260 270 280 290 300
290 300 310 320 330 340
pF1KSD GSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRF
310 320 330 340 350 360
350 360 370 380 390 400
pF1KSD YPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KSD GPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSP
430 440 450 460 470 480
470 480 490 500
pF1KSD SQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPK------------
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPKYDYLGDRRPVPA
490 500 510 520 530 540
pF1KSD ------------------------------------------------------------
XP_016 GLFPYNYPPSPTVHDKMDELLDLQLQRNLEYLDQQMSESETLISMVNRMVENSSPRSQLF
550 560 570 580 590 600
510 520 530 540 550 560
pF1KSD --VPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MQVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALM
610 620 630 640 650 660
570 580 590 600 610 620
pF1KSD GTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSA
670 680 690 700 710 720
630 640 650 660 670 680
pF1KSD LHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATY
730 740 750 760 770 780
690 700 710 720
pF1KSD SSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNE----------------------
::::::::::::::::::::::::::::::::::::::
XP_016 SSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEEPGPPRPPLPKAYVPLESPPAV
790 800 810 820 830 840
730 740 750
pF1KSD ----------------------------PKANYEQSKKDPHQTLPLDTPRDISLVPTRQE
::::::::::::::::::::::::::::::::
XP_016 PPLPSESRFWPYPSSPSWHRSGETARGQPKANYEQSKKDPHQTLPLDTPRDISLVPTRQE
850 860 870 880 890 900
760 770 780 790 800 810
pF1KSD VEAEKQAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQERPKSAVFPGEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEAEKQAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQERPKSAVFPGEGK
910 920 930 940 950 960
820 830 840 850 860 870
pF1KSD VKMSVEEQIDRMRRHQSGSMKEKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNL
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
XP_016 VKMSVEEQIDRMRRHQSGSMREKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISNL
970 980 990 1000 1010 1020
880 890 900 910 920 930
pF1KSD EAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEPD
1030 1040 1050 1060 1070 1080
940 950 960 970 980 990
pF1KSD TPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISC
::::::::::::::::::::
XP_016 TPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEISC
1090 1100 1110 1120 1130 1140
>--
initn: 350 init1: 350 opt: 350 Z-score: 196.6 bits: 48.2 E(85289): 0.00033
Smith-Waterman score: 350; 100.0% identity (100.0% similar) in 56 aa overlap (957-1012:1101-1156)
930 940 950 960 970 980
pF1KSD PERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQ
::::::::::::::::::::::::::::::
XP_016 PERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQ
1080 1090 1100 1110 1120 1130
990 1000 1010 1020 1030 1040
pF1KSD EQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYTM
::::::::::::::::::::::::::
XP_016 EQEKRIEISCALATEASRRGRMLSVQALAEANAVKLHRATF
1140 1150 1160 1170
>>XP_006711277 (OMIM: 607771) PREDICTED: pleckstrin homo (1172 aa)
initn: 4146 init1: 2724 opt: 2768 Z-score: 1445.0 bits: 279.2 E(85289): 9.5e-74
Smith-Waterman score: 6168; 86.6% identity (86.8% similar) in 1100 aa overlap (1-955:1-1100)
10 20 30 40 50 60
pF1KSD MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAIAFGKRSHSMKRNPNAPV
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_006 MSNKTGGKRPATTNSDIPNHNMVSEVPPERPSVRATRTARKAVAFGKRSHSMKRNPNAPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI
70 80 90 100 110 120
130 140 150 160
pF1KSD SRKHTFK--------------------AEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQ
::::::: :::::::::::::::::::::::::::::::::
XP_006 SRKHTFKVTVCWVDEAEASSTRCLSPQAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQ
130 140 150 160 170 180
170 180 190 200 210 220
pF1KSD IPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IPPAQKSVPQAVRHSHEKPDSENVPPSKHHQQPPHNSLPKPEPEAKTRGEGDGRGCEKAE
190 200 210 220 230 240
230 240 250 260 270 280
pF1KSD RRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRPERPEVKKEPPVKANGLPAGPEPASEPGSPYPEGPRVPGGGEQPAQPNGWQYHSPSRP
250 260 270 280 290 300
290 300 310 320 330 340
pF1KSD GSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSTAFPSQDGETGGHRRSFPPRTNPDKIAQRKSSMNQLQQWVNLRRGVPPPEDLRSPSRF
310 320 330 340 350 360
350 360 370 380 390 400
pF1KSD YPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YPVSRRVPEYYGPYSSQYPDDYQYYPPGVRPESICSMPAYDRISPPWALEDKRHAFRNGG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KSD GPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GPAYQLREWKEPASYGRQDATVWIPSPSRQPVYYDELDAASSSLRRLSLQPRSHSVPRSP
430 440 450 460 470 480
470 480 490 500
pF1KSD SQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPK------------
::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SQGSYSRARIYSPVRSPSARFERLPPRSEDIYADPAAYVMRRSISSPKYDYLGDRRPVPA
490 500 510 520 530 540
pF1KSD ------------------------------------------------------------
XP_006 GLFPYNYPPSPTVHDKMDELLDLQLQRNLEYLDQQMSESETLISMVNRMVENSSPRSQLF
550 560 570 580 590 600
510 520 530 540 550 560
pF1KSD --VPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MQVPPYPEVFRDSLHTYKLNEQDTDKLLGKLCEQNKVVREQDRLVQQLRAEKESLESALM
610 620 630 640 650 660
570 580 590 600 610 620
pF1KSD GTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GTHQELEMFGSQPAYPEKLRHKKDSLQNQLINIRVELSQATTALTNSTIEYEHLESEVSA
670 680 690 700 710 720
630 640 650 660 670 680
pF1KSD LHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LHDDLWEQLNLDTQNEVLNRQIQKEIWRIQDVMEGLRKNNPSRGTDTAKHRGGLGPSATY
730 740 750 760 770 780
690 700 710 720
pF1KSD SSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNE----------------------
::::::::::::::::::::::::::::::::::::::
XP_006 SSNSPASPLSSASLTSPLSPFSLVSGSQGSPTKPGSNEEPGPPRPPLPKAYVPLESPPAV
790 800 810 820 830 840
730 740 750
pF1KSD ----------------------------PKANYEQSKKDPHQTLPLDTPRDISLVPTRQE
::::::::::::::::::::::::::::::::
XP_006 PPLPSESRFWPYPSSPSWHRSGETARGQPKANYEQSKKDPHQTLPLDTPRDISLVPTRQE
850 860 870 880 890 900
760 770 780 790 800 810
pF1KSD VEAEKQAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQ-ERPKSAVFPGEG
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_006 VEAEKQAALNKVGVVPPRTKSPTDDEVTPSAVVRRNASGLTNGLSSQQERPKSAVFPGEG
910 920 930 940 950 960
820 830 840 850 860 870
pF1KSD KVKMSVEEQIDRMRRHQSGSMKEKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISN
:::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::
XP_006 KVKMSVEEQIDRMRRHQSGSMREKRRSLQLPASPAPDPSPRPAYKVVRRHRSIHEVDISN
970 980 990 1000 1010 1020
880 890 900 910 920 930
pF1KSD LEAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEAALRAEEPGGHAYETPREEIARLRKMELEPQHYDVDINKELSTPDKVLIPERYIDLEP
1030 1040 1050 1060 1070 1080
940 950 960 970 980 990
pF1KSD DTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEIS
::::::::::::::::::::
XP_006 DTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQLQEQEKRIEIS
1090 1100 1110 1120 1130 1140
>--
initn: 355 init1: 355 opt: 355 Z-score: 199.2 bits: 48.7 E(85289): 0.00023
Smith-Waterman score: 355; 100.0% identity (100.0% similar) in 57 aa overlap (956-1012:1101-1157)
930 940 950 960 970 980
pF1KSD IPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQL
::::::::::::::::::::::::::::::
XP_006 IPERYIDLEPDTPLSPEELKEKQKKVERIKTLIAKSSMQNVVPIGEGDSVDVPQDSESQL
1080 1090 1100 1110 1120 1130
990 1000 1010 1020 1030 1040
pF1KSD QEQEKRIEISCALATEASRRGRMLSVQCATPSPPTSPASPAPPANPLSSESPRGADSSYT
:::::::::::::::::::::::::::
XP_006 QEQEKRIEISCALATEASRRGRMLSVQALAEANAVKLHRATF
1140 1150 1160 1170
1048 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 04:29:40 2016 done: Thu Nov 3 04:29:43 2016
Total Scan time: 17.840 Total Display time: 0.430
Function used was FASTA [36.3.4 Apr, 2011]