FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1014, 1017 aa 1>>>pF1KSDA1014 1017 - 1017 aa - 1017 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 13.9034+/-0.000448; mu= -15.3822+/- 0.028 mean_var=585.5475+/-119.306, 0's: 0 Z-trim(124.7): 20 B-trim: 0 in 0/62 Lambda= 0.053002 statistics sampled from 46790 (46824) to 46790 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.788), E-opt: 0.2 (0.549), width: 16 Scan time: 17.970 The best scores are: opt bits E(85289) NP_001305268 (OMIM: 615265) formin-binding protein (1019) 6721 529.4 3.8e-149 NP_056123 (OMIM: 615265) formin-binding protein 4 (1017) 6693 527.3 1.7e-148 >>NP_001305268 (OMIM: 615265) formin-binding protein 4 i (1019 aa) initn: 6391 init1: 6391 opt: 6721 Z-score: 2798.7 bits: 529.4 E(85289): 3.8e-149 Smith-Waterman score: 6721; 99.8% identity (99.8% similar) in 1019 aa overlap (1-1017:1-1019) 10 20 30 40 50 pF1KSD MGKKSRAVPGRRPILQLSPPGPRGSTPGRDPEPEPDTEPDSTAAVPSQPAPSAATTT--A ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: : NP_001 MGKKSRAVPGRRPILQLSPPGPRGSTPGRDPEPEPDTEPDSTAAVPSQPAPSAATTTTTA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KSD VTAAAASDDSPSEGKDEQEAVQEVPRVVQNPPKPVMTTRPTAVKATGGLCLLGAYADSDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTAAAASDDSPSEGKDEQEAVQEVPRVVQNPPKPVMTTRPTAVKATGGLCLLGAYADSDD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KSD DDNDVSEKLAQSKETNGNQSTDIDSTLANFLAEIDAITAPQPAAPVGASAPPPTPPRPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDNDVSEKLAQSKETNGNQSTDIDSTLANFLAEIDAITAPQPAAPVGASAPPPTPPRPEP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KSD KEAATSTLSSSTSNGTDSTQTSGWQYDTQCSLAGVGIEMGDWQEVWDENTGCYYYWNTQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEAATSTLSSSTSNGTDSTQTSGWQYDTQCSLAGVGIEMGDWQEVWDENTGCYYYWNTQT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KSD NEVTWELPQYLATQVQGLQHYQPSSVPGAETSFVVNTDIYSKEKTISVSSSKSGPVIAKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEVTWELPQYLATQVQGLQHYQPSSVPGAETSFVVNTDIYSKEKTISVSSSKSGPVIAKR 250 260 270 280 290 300 300 310 320 330 340 350 pF1KSD EVKKEVNEGIQALSNSEEEKKGVAASLLAPLLPEGIKEEEERWRRKVICKEEPVSEVKET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVKKEVNEGIQALSNSEEEKKGVAASLLAPLLPEGIKEEEERWRRKVICKEEPVSEVKET 310 320 330 340 350 360 360 370 380 390 400 410 pF1KSD STTVEEATTIVKPQEIMLDNIEDPSQEDLCSVVQSGESEEEEEQDTLELELVLERKKAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STTVEEATTIVKPQEIMLDNIEDPSQEDLCSVVQSGESEEEEEQDTLELELVLERKKAEL 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD RALEEGDGSVSGSSPRSDISQPASQDGMRRLMSKRGKWKMFVRATSPESTSRSSSKTGRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RALEEGDGSVSGSSPRSDISQPASQDGMRRLMSKRGKWKMFVRATSPESTSRSSSKTGRD 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD TPENGETAIGAENSEKIDENSDKEMEVEESPEKIKVQTTPKVEEEQDLKFQIGELANTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPENGETAIGAENSEKIDENSDKEMEVEESPEKIKVQTTPKVEEEQDLKFQIGELANTLT 490 500 510 520 530 540 540 550 560 570 580 590 pF1KSD SKFEFLGINRQSISNFHVLLLQTETRIADWREGALNGNYLKRKLQDAAEQLKQYEINATP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKFEFLGINRQSISNFHVLLLQTETRIADWREGALNGNYLKRKLQDAAEQLKQYEINATP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KSD KGWSCHWDRDHRRYFYVNEQSGESQWEFPDGEEEEEESQAQENRDETLAKQTLKDKTGTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGWSCHWDRDHRRYFYVNEQSGESQWEFPDGEEEEEESQAQENRDETLAKQTLKDKTGTD 610 620 630 640 650 660 660 670 680 690 700 710 pF1KSD SNSTESSETSTGSLCKESFSGQVSSSSLMPLTPFWTLLQSNVPVLQPPLPLEMPPPPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNSTESSETSTGSLCKESFSGQVSSSSLMPLTPFWTLLQSNVPVLQPPLPLEMPPPPPPP 670 680 690 700 710 720 720 730 740 750 760 770 pF1KSD PESPPPPPPPPPPAEDGEIQEVEMEDEGSEEPPAPGTEEDTPLKPSAQTTVVTSQSSVDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PESPPPPPPPPPPAEDGEIQEVEMEDEGSEEPPAPGTEEDTPLKPSAQTTVVTSQSSVDS 730 740 750 760 770 780 780 790 800 810 820 830 pF1KSD TISSSSSTKGIKRKATEISTAVVQRSATIGSSPVLYSQSAIATGHQAAGIGNQATGIGHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TISSSSSTKGIKRKATEISTAVVQRSATIGSSPVLYSQSAIATGHQAAGIGNQATGIGHQ 790 800 810 820 830 840 840 850 860 870 880 890 pF1KSD TIPVSLPAAGMGHQARGMSLQSNYLGLAAAPAIMSYAECSVPIGVTAPSLQPVQARGAVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIPVSLPAAGMGHQARGMSLQSNYLGLAAAPAIMSYAECSVPIGVTAPSLQPVQARGAVP 850 860 870 880 890 900 900 910 920 930 940 950 pF1KSD TATIIEPPPPPPPPPPPPPPAPKMPPPEKTKKGRKDKAKKSKTKMPSLVKKWQSIQRELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TATIIEPPPPPPPPPPPPPPAPKMPPPEKTKKGRKDKAKKSKTKMPSLVKKWQSIQRELD 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KSD EEDNSSSSEEDRESTAQKRIEEWKQQQLVSGMAERNANFEALPEDWRARLKRRKMAPNT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEDNSSSSEEDRESTAQKRIEEWKQQQLVSGMAERNANFEALPEDWRARLKRRKMAPNT 970 980 990 1000 1010 >>NP_056123 (OMIM: 615265) formin-binding protein 4 isof (1017 aa) initn: 6652 init1: 6652 opt: 6693 Z-score: 2787.2 bits: 527.3 E(85289): 1.7e-148 Smith-Waterman score: 6693; 99.6% identity (99.6% similar) in 1019 aa overlap (1-1017:1-1017) 10 20 30 40 50 pF1KSD MGKKSRAVPGRRPILQLSPPGPRGSTPGRDPEPEPDTEPDSTAAVPSQPAPSAATTT--A ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: : NP_056 MGKKSRAVPGRRPILQLSPPGPRGSTPGRDPEPEPDTEPDSTAAVPSQPAPSAATTTTTA 10 20 30 40 50 60 60 70 80 90 100 110 pF1KSD VTAAAASDDSPSEGKDEQEAVQEVPRVVQNPPKPVMTTRPTAVKATGGLCLLGAYADSDD ::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::: NP_056 VTAAAASDDSPSE--DEQEAVQEVPRVVQNPPKPVMTTRPTAVKATGGLCLLGAYADSDD 70 80 90 100 110 120 130 140 150 160 170 pF1KSD DDNDVSEKLAQSKETNGNQSTDIDSTLANFLAEIDAITAPQPAAPVGASAPPPTPPRPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 DDNDVSEKLAQSKETNGNQSTDIDSTLANFLAEIDAITAPQPAAPVGASAPPPTPPRPEP 120 130 140 150 160 170 180 190 200 210 220 230 pF1KSD KEAATSTLSSSTSNGTDSTQTSGWQYDTQCSLAGVGIEMGDWQEVWDENTGCYYYWNTQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KEAATSTLSSSTSNGTDSTQTSGWQYDTQCSLAGVGIEMGDWQEVWDENTGCYYYWNTQT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KSD NEVTWELPQYLATQVQGLQHYQPSSVPGAETSFVVNTDIYSKEKTISVSSSKSGPVIAKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 NEVTWELPQYLATQVQGLQHYQPSSVPGAETSFVVNTDIYSKEKTISVSSSKSGPVIAKR 240 250 260 270 280 290 300 310 320 330 340 350 pF1KSD EVKKEVNEGIQALSNSEEEKKGVAASLLAPLLPEGIKEEEERWRRKVICKEEPVSEVKET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 EVKKEVNEGIQALSNSEEEKKGVAASLLAPLLPEGIKEEEERWRRKVICKEEPVSEVKET 300 310 320 330 340 350 360 370 380 390 400 410 pF1KSD STTVEEATTIVKPQEIMLDNIEDPSQEDLCSVVQSGESEEEEEQDTLELELVLERKKAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 STTVEEATTIVKPQEIMLDNIEDPSQEDLCSVVQSGESEEEEEQDTLELELVLERKKAEL 360 370 380 390 400 410 420 430 440 450 460 470 pF1KSD RALEEGDGSVSGSSPRSDISQPASQDGMRRLMSKRGKWKMFVRATSPESTSRSSSKTGRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 RALEEGDGSVSGSSPRSDISQPASQDGMRRLMSKRGKWKMFVRATSPESTSRSSSKTGRD 420 430 440 450 460 470 480 490 500 510 520 530 pF1KSD TPENGETAIGAENSEKIDENSDKEMEVEESPEKIKVQTTPKVEEEQDLKFQIGELANTLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 TPENGETAIGAENSEKIDENSDKEMEVEESPEKIKVQTTPKVEEEQDLKFQIGELANTLT 480 490 500 510 520 530 540 550 560 570 580 590 pF1KSD SKFEFLGINRQSISNFHVLLLQTETRIADWREGALNGNYLKRKLQDAAEQLKQYEINATP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SKFEFLGINRQSISNFHVLLLQTETRIADWREGALNGNYLKRKLQDAAEQLKQYEINATP 540 550 560 570 580 590 600 610 620 630 640 650 pF1KSD KGWSCHWDRDHRRYFYVNEQSGESQWEFPDGEEEEEESQAQENRDETLAKQTLKDKTGTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KGWSCHWDRDHRRYFYVNEQSGESQWEFPDGEEEEEESQAQENRDETLAKQTLKDKTGTD 600 610 620 630 640 650 660 670 680 690 700 710 pF1KSD SNSTESSETSTGSLCKESFSGQVSSSSLMPLTPFWTLLQSNVPVLQPPLPLEMPPPPPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SNSTESSETSTGSLCKESFSGQVSSSSLMPLTPFWTLLQSNVPVLQPPLPLEMPPPPPPP 660 670 680 690 700 710 720 730 740 750 760 770 pF1KSD PESPPPPPPPPPPAEDGEIQEVEMEDEGSEEPPAPGTEEDTPLKPSAQTTVVTSQSSVDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 PESPPPPPPPPPPAEDGEIQEVEMEDEGSEEPPAPGTEEDTPLKPSAQTTVVTSQSSVDS 720 730 740 750 760 770 780 790 800 810 820 830 pF1KSD TISSSSSTKGIKRKATEISTAVVQRSATIGSSPVLYSQSAIATGHQAAGIGNQATGIGHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 TISSSSSTKGIKRKATEISTAVVQRSATIGSSPVLYSQSAIATGHQAAGIGNQATGIGHQ 780 790 800 810 820 830 840 850 860 870 880 890 pF1KSD TIPVSLPAAGMGHQARGMSLQSNYLGLAAAPAIMSYAECSVPIGVTAPSLQPVQARGAVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 TIPVSLPAAGMGHQARGMSLQSNYLGLAAAPAIMSYAECSVPIGVTAPSLQPVQARGAVP 840 850 860 870 880 890 900 910 920 930 940 950 pF1KSD TATIIEPPPPPPPPPPPPPPAPKMPPPEKTKKGRKDKAKKSKTKMPSLVKKWQSIQRELD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 TATIIEPPPPPPPPPPPPPPAPKMPPPEKTKKGRKDKAKKSKTKMPSLVKKWQSIQRELD 900 910 920 930 940 950 960 970 980 990 1000 1010 pF1KSD EEDNSSSSEEDRESTAQKRIEEWKQQQLVSGMAERNANFEALPEDWRARLKRRKMAPNT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 EEDNSSSSEEDRESTAQKRIEEWKQQQLVSGMAERNANFEALPEDWRARLKRRKMAPNT 960 970 980 990 1000 1010 1017 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 04:37:12 2016 done: Thu Nov 3 04:37:14 2016 Total Scan time: 17.970 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]