FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1048, 863 aa 1>>>pF1KSDA1048 863 - 863 aa - 863 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 15.9102+/-0.00128; mu= -24.2044+/- 0.077 mean_var=753.0222+/-161.394, 0's: 0 Z-trim(115.7): 72 B-trim: 0 in 0/54 Lambda= 0.046738 statistics sampled from 16210 (16267) to 16210 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.77), E-opt: 0.2 (0.5), width: 16 Scan time: 4.670 The best scores are: opt bits E(32554) CCDS1893.2 AAK1 gene_id:22848|Hs108|chr2 ( 961) 5554 390.3 9e-108 CCDS34019.1 BMP2K gene_id:55589|Hs108|chr4 ( 662) 2144 160.2 1.1e-38 CCDS47083.1 BMP2K gene_id:55589|Hs108|chr4 (1161) 2149 160.7 1.3e-38 >>CCDS1893.2 AAK1 gene_id:22848|Hs108|chr2 (961 aa) initn: 5772 init1: 5554 opt: 5554 Z-score: 2048.4 bits: 390.3 E(32554): 9e-108 Smith-Waterman score: 5554; 98.9% identity (99.6% similar) in 833 aa overlap (1-833:1-833) 10 20 30 40 50 60 pF1KSD MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD AQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: CCDS18 AQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIGKVIISVSSVMHDMCACF :::::::::::::::::::::::::::::::::::::::::: :. ..: :.. CCDS18 PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV 790 800 810 820 830 840 850 860 pF1KSD KNDKYLVNQSLGNSPATPEAKAI CCDS18 PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL 850 860 870 880 890 900 >>CCDS34019.1 BMP2K gene_id:55589|Hs108|chr4 (662 aa) initn: 1743 init1: 1535 opt: 2144 Z-score: 807.9 bits: 160.2 E(32554): 1.1e-38 Smith-Waterman score: 2264; 52.7% identity (69.7% similar) in 732 aa overlap (1-723:1-652) 10 20 30 40 50 pF1KSD MKKFFDSRREQGGSGLGS--GSSGGGGSTSGLGSG--YIG-RVFGIGRQQVTVDEVLAEG :::: . .:::: :. :..::.:. .: ::: .: :::..::.:::..: :::: CCDS34 MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KSD GFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVS ::. :::::: .:..::::::.::: ::.:::::: ::..::::::::::.: ..:..: CCDS34 GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KSD SGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHR . .::::::::..::.::::: ::..::::::: :::::::::::::::::::::::::: CCDS34 D-NVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHR 130 140 150 160 170 180 190 200 210 220 230 pF1KSD DLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYS :::::::::.: :.::::::::::::: ::: .:::.::.:::::::::::::::.:::. CCDS34 DLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KSD GKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLE :: ::::::::::::::::::.::::::::::::::::::::::::::...:::::.::: CCDS34 GKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KSD PDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTD :::..::::.:::::.::. ::.::. :..:: ::. ::::. ::::::.:.: :::.:: CCDS34 PDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITD 300 310 320 330 340 350 360 370 380 390 400 410 pF1KSD PIPTTETSIAPRQRPKAGQ-TQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLAS : :::::::::::::.. : .:..: :: . :: : . : :. : : CCDS34 TIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLA----PGEFGNHRPKGALRP 360 370 380 390 400 410 420 430 440 450 460 470 pF1KSD VPQPK---PQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQ :. :.::.:: :: . :: . . . . : :::: .: CCDS34 GNGPEILLGQGPPQQP--------PQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQ---QQ 420 430 440 450 460 480 490 500 510 520 530 pF1KSD QQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNF :::::: ::: :::: : :: . : ...:.:. CCDS34 QQQQQQQQQQQQQ------QQQQQQQQQHHHHH-------------------HHHLLQDA 470 480 490 540 550 560 570 580 590 pF1KSD YQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEP :.:: :. ::::. :::. : . ::::. . : : . CCDS34 YMQQYQHATQQQQM-----------------LQQQFLMHSVYQPQPSASQYPTMMPQYQ- 500 510 520 530 540 600 610 620 630 640 650 pF1KSD AIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASK :: .:: .: : .:. .: .::. .: . : . ..::. CCDS34 --QAFFQQQMLAQHQP-----SQQQASPEYLTSPQE--------FSPALVSYTSSLPAQV 550 560 570 580 660 670 680 690 700 710 pF1KSD STQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEEL .: . ..: . ..:.. . . :.:.:. :: . : :::: .::::::: ::: CCDS34 GTIM------DSSYSANRSVADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEEL 590 600 610 620 630 640 720 730 740 750 760 770 pF1KSD LNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLP :...: : .: CCDS34 LDREFDLLRSSKGHLKAYFASQ 650 660 >>CCDS47083.1 BMP2K gene_id:55589|Hs108|chr4 (1161 aa) initn: 1743 init1: 1535 opt: 2149 Z-score: 806.4 bits: 160.7 E(32554): 1.3e-38 Smith-Waterman score: 2286; 50.5% identity (68.7% similar) in 780 aa overlap (1-767:1-700) 10 20 30 40 50 pF1KSD MKKFFDSRREQGGSGLGS--GSSGGGGSTSGLGSG--YIG-RVFGIGRQQVTVDEVLAEG :::: . .:::: :. :..::.:. .: ::: .: :::..::.:::..: :::: CCDS47 MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KSD GFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVS ::. :::::: .:..::::::.::: ::.:::::: ::..::::::::::.: ..:..: CCDS47 GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KSD SGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHR . .::::::::..::.::::: ::..::::::: :::::::::::::::::::::::::: CCDS47 D-NVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHR 130 140 150 160 170 180 190 200 210 220 230 pF1KSD DLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYS :::::::::.: :.::::::::::::: ::: .:::.::.:::::::::::::::.:::. CCDS47 DLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KSD GKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLE :: ::::::::::::::::::.::::::::::::::::::::::::::...:::::.::: CCDS47 GKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLE 240 250 260 270 280 290 300 310 320 330 340 350 pF1KSD PDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTD :::..::::.:::::.::. ::.::. :..:: ::. ::::. ::::::.:.: :::.:: CCDS47 PDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITD 300 310 320 330 340 350 360 370 380 390 400 410 pF1KSD PIPTTETSIAPRQRPKAGQ-TQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLAS : :::::::::::::.. : .:..: :: . :: : . : :. : : CCDS47 TIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLA----PGEFGNHRPKGALRP 360 370 380 390 400 410 420 430 440 450 460 470 pF1KSD VPQPK---PQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQ :. :.::.:: :: . :: . . . . : :::: .: CCDS47 GNGPEILLGQGPPQQP--------PQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQ---QQ 420 430 440 450 460 480 490 500 510 520 530 pF1KSD QQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNF :::::: ::: :::: : :: . : ...:.:. CCDS47 QQQQQQQQQQQQQ------QQQQQQQQQHHHHH-------------------HHHLLQDA 470 480 490 540 550 560 570 580 590 pF1KSD YQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEP :.:: :. ::::. :::. : . ::::. . : : . CCDS47 YMQQYQHATQQQQM-----------------LQQQFLMHSVYQPQPSASQYPTMMPQYQ- 500 510 520 530 540 600 610 620 630 640 650 pF1KSD AIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASK :: .:: .: : .:. .: .::. .: . : . ..::. CCDS47 --QAFFQQQMLAQHQP-----SQQQASPEYLTSPQE--------FSPALVSYTSSLPAQV 550 560 570 580 660 670 680 690 700 710 pF1KSD STQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEEL .: . ..: . ..:.. . . :.:.:. :: . : :::: .::::::: ::: CCDS47 GTIM------DSSYSANRSVADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEEL 590 600 610 620 630 640 720 730 740 750 760 pF1KSD LNKDFAKLGEGKHPEKLGG--SAESLIPGFQSTQGDAFATTSF--SAGTAEKRKGGQTVD :...: : .. :. .. ...:: . : :... : .:. ::. .... CCDS47 LDREFDLLRSNRLEERASSDKNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKKAEHSSIN 650 660 670 680 690 700 770 780 790 800 810 820 pF1KSD SGLPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIGKVII CCDS47 QENGTANPIKNGKTSPASKDQRTGKKTSVQGQVQKGNDESESDFESDPPSPKSSEEEEQD 710 720 730 740 750 760 863 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 04:43:49 2016 done: Thu Nov 3 04:43:49 2016 Total Scan time: 4.670 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]