Result of FASTA (omim) for
pF1KSDA1083
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1083, 584 aa
1>>>pF1KSDA1083 584 - 584 aa - 584 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.4808+/-0.000358; mu= 8.0630+/- 0.023
mean_var=255.8290+/-51.723, 0's: 0 Z-trim(122.4): 160 B-trim: 0 in 0/58
Lambda= 0.080186
statistics sampled from 40251 (40421) to 40251 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.758), E-opt: 0.2 (0.474), width: 16
Scan time: 12.030
The best scores are: opt bits E(85289)
NP_955468 (OMIM: 182601,604277) spastin isoform 2 ( 584) 3811 454.0 6.3e-127
XP_016860266 (OMIM: 182601,604277) PREDICTED: spas ( 583) 3794 452.0 2.5e-126
XP_016860267 (OMIM: 182601,604277) PREDICTED: spas ( 519) 3321 397.2 6.8e-110
XP_005264573 (OMIM: 182601,604277) PREDICTED: spas ( 615) 2489 301.1 7.2e-81
NP_055761 (OMIM: 182601,604277) spastin isoform 1 ( 616) 2489 301.1 7.2e-81
XP_011531369 (OMIM: 182601,604277) PREDICTED: spas ( 551) 1999 244.3 7.7e-64
NP_001274425 (OMIM: 615383) fidgetin-like protein ( 563) 1108 141.3 8.4e-33
NP_001333488 (OMIM: 615383) fidgetin-like protein ( 563) 1108 141.3 8.4e-33
NP_001333487 (OMIM: 615383) fidgetin-like protein ( 563) 1108 141.3 8.4e-33
NP_001333489 (OMIM: 615383) fidgetin-like protein ( 674) 1108 141.4 9.4e-33
NP_001333493 (OMIM: 615383) fidgetin-like protein ( 674) 1108 141.4 9.4e-33
NP_001333490 (OMIM: 615383) fidgetin-like protein ( 674) 1108 141.4 9.4e-33
NP_001333494 (OMIM: 615383) fidgetin-like protein ( 674) 1108 141.4 9.4e-33
NP_001333492 (OMIM: 615383) fidgetin-like protein ( 674) 1108 141.4 9.4e-33
NP_001274424 (OMIM: 615383) fidgetin-like protein ( 674) 1108 141.4 9.4e-33
NP_001333491 (OMIM: 615383) fidgetin-like protein ( 674) 1108 141.4 9.4e-33
NP_001274421 (OMIM: 615383) fidgetin-like protein ( 674) 1108 141.4 9.4e-33
NP_001274422 (OMIM: 615383) fidgetin-like protein ( 674) 1108 141.4 9.4e-33
XP_011513772 (OMIM: 615383) PREDICTED: fidgetin-li ( 674) 1108 141.4 9.4e-33
XP_016867990 (OMIM: 615383) PREDICTED: fidgetin-li ( 674) 1108 141.4 9.4e-33
NP_001036227 (OMIM: 615383) fidgetin-like protein ( 674) 1108 141.4 9.4e-33
NP_001274423 (OMIM: 615383) fidgetin-like protein ( 674) 1108 141.4 9.4e-33
NP_071399 (OMIM: 615383) fidgetin-like protein 1 i ( 674) 1108 141.4 9.4e-33
NP_001308754 (OMIM: 605295) fidgetin isoform 2 [Ho ( 748) 869 113.8 2.1e-24
NP_060556 (OMIM: 605295) fidgetin isoform 1 [Homo ( 759) 869 113.8 2.2e-24
XP_016859908 (OMIM: 605295) PREDICTED: fidgetin is ( 785) 869 113.8 2.2e-24
XP_011509691 (OMIM: 605295) PREDICTED: fidgetin is ( 785) 869 113.8 2.2e-24
XP_011524570 (OMIM: 609983) PREDICTED: vacuolar pr ( 418) 792 104.6 6.9e-22
NP_004860 (OMIM: 609983) vacuolar protein sorting- ( 444) 792 104.6 7.2e-22
XP_006722645 (OMIM: 609983) PREDICTED: vacuolar pr ( 326) 768 101.7 4e-21
NP_037377 (OMIM: 609982) vacuolar protein sorting- ( 437) 759 100.8 1e-20
XP_005266861 (OMIM: 606696) PREDICTED: katanin p60 ( 491) 740 98.6 5e-20
XP_016865699 (OMIM: 606696) PREDICTED: katanin p60 ( 491) 740 98.6 5e-20
NP_008975 (OMIM: 606696) katanin p60 ATPase-contai ( 491) 740 98.6 5e-20
XP_016865696 (OMIM: 606696) PREDICTED: katanin p60 ( 491) 740 98.6 5e-20
XP_005266631 (OMIM: 614764) PREDICTED: katanin p60 ( 490) 726 97.0 1.5e-19
NP_115492 (OMIM: 614764) katanin p60 ATPase-contai ( 490) 726 97.0 1.5e-19
NP_001014402 (OMIM: 614764) katanin p60 ATPase-con ( 490) 726 97.0 1.5e-19
XP_016876282 (OMIM: 614764) PREDICTED: katanin p60 ( 322) 722 96.4 1.6e-19
XP_016876281 (OMIM: 614764) PREDICTED: katanin p60 ( 322) 722 96.4 1.6e-19
XP_016876280 (OMIM: 614764) PREDICTED: katanin p60 ( 322) 722 96.4 1.6e-19
XP_005258418 (OMIM: 614697) PREDICTED: katanin p60 ( 427) 703 94.3 8.8e-19
XP_016881520 (OMIM: 614697) PREDICTED: katanin p60 ( 427) 703 94.3 8.8e-19
XP_016881519 (OMIM: 614697) PREDICTED: katanin p60 ( 465) 703 94.3 9.3e-19
NP_112593 (OMIM: 614697) katanin p60 ATPase-contai ( 466) 703 94.3 9.3e-19
XP_006722617 (OMIM: 614697) PREDICTED: katanin p60 ( 538) 703 94.4 1e-18
XP_005258415 (OMIM: 614697) PREDICTED: katanin p60 ( 563) 703 94.4 1.1e-18
XP_005258414 (OMIM: 614697) PREDICTED: katanin p60 ( 564) 703 94.4 1.1e-18
XP_016865697 (OMIM: 606696) PREDICTED: katanin p60 ( 363) 688 92.5 2.6e-18
XP_016865698 (OMIM: 606696) PREDICTED: katanin p60 ( 363) 688 92.5 2.6e-18
>>NP_955468 (OMIM: 182601,604277) spastin isoform 2 [Hom (584 aa)
initn: 3811 init1: 3811 opt: 3811 Z-score: 2399.7 bits: 454.0 E(85289): 6.3e-127
Smith-Waterman score: 3811; 100.0% identity (100.0% similar) in 584 aa overlap (1-584:1-584)
10 20 30 40 50 60
pF1KSD MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD MMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 MMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD SMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSNLANLIMNEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 SMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSNLANLIMNEI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD VDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 VDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 KAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERRE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD GEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 GEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD TRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 TRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNM
490 500 510 520 530 540
550 560 570 580
pF1KSD SASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFGDTTV
::::::::::::::::::::::::::::::::::::::::::::
NP_955 SASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFGDTTV
550 560 570 580
>>XP_016860266 (OMIM: 182601,604277) PREDICTED: spastin (583 aa)
initn: 2846 init1: 2846 opt: 3794 Z-score: 2389.1 bits: 452.0 E(85289): 2.5e-126
Smith-Waterman score: 3794; 99.8% identity (99.8% similar) in 584 aa overlap (1-584:1-583)
10 20 30 40 50 60
pF1KSD MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_016 KQAFEYISIALRIDEDEK-GQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
130 140 150 160 170
190 200 210 220 230 240
pF1KSD MMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KSD SMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSNLANLIMNEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSNLANLIMNEI
240 250 260 270 280 290
310 320 330 340 350 360
pF1KSD VDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLA
300 310 320 330 340 350
370 380 390 400 410 420
pF1KSD KAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERRE
360 370 380 390 400 410
430 440 450 460 470 480
pF1KSD GEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEE
420 430 440 450 460 470
490 500 510 520 530 540
pF1KSD TRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNM
480 490 500 510 520 530
550 560 570 580
pF1KSD SASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFGDTTV
::::::::::::::::::::::::::::::::::::::::::::
XP_016 SASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKDFGDTTV
540 550 560 570 580
>>XP_016860267 (OMIM: 182601,604277) PREDICTED: spastin (519 aa)
initn: 3321 init1: 3321 opt: 3321 Z-score: 2093.9 bits: 397.2 E(85289): 6.8e-110
Smith-Waterman score: 3321; 100.0% identity (100.0% similar) in 507 aa overlap (1-507:1-507)
10 20 30 40 50 60
pF1KSD MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD MMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD SMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSNLANLIMNEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMVSGVKQGSGPAPTTHKGTPKTNRTNKPSTPTTATRKKKDLKNFRNVDSNLANLIMNEI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD VDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERRE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD GEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD TRLLLLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNM
:::::::::::::::::::::::::::
XP_016 TRLLLLKNLLCKQGSPLTQKELAQLARTKTRTGEEYVCQ
490 500 510
>>XP_005264573 (OMIM: 182601,604277) PREDICTED: spastin (615 aa)
initn: 3435 init1: 2480 opt: 2489 Z-score: 1572.9 bits: 301.1 E(85289): 7.2e-81
Smith-Waterman score: 3720; 94.6% identity (94.6% similar) in 616 aa overlap (1-584:1-615)
10 20 30 40 50 60
pF1KSD MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_005 KQAFEYISIALRIDEDEK-GQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
130 140 150 160 170
190 200
pF1KSD MMTNLVMAKDRLQLLE--------------------------------SGAVPKRKDPLT
:::::::::::::::: ::::::::::::
XP_005 MMTNLVMAKDRLQLLEKMQPVLPFSKSQTDVYNDSTNLACRNGHLQSESGAVPKRKDPLT
180 190 200 210 220 230
210 220 230 240 250 260
pF1KSD HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK
240 250 260 270 280 290
270 280 290 300 310 320
pF1KSD PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL
300 310 320 330 340 350
330 340 350 360 370 380
pF1KSD PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE
360 370 380 390 400 410
390 400 410 420 430 440
pF1KSD KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV
420 430 440 450 460 470
450 460 470 480 490 500
pF1KSD LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARM
480 490 500 510 520 530
510 520 530 540 550 560
pF1KSD TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQT
540 550 560 570 580 590
570 580
pF1KSD LEAYIRWNKDFGDTTV
::::::::::::::::
XP_005 LEAYIRWNKDFGDTTV
600 610
>>NP_055761 (OMIM: 182601,604277) spastin isoform 1 [Hom (616 aa)
initn: 2480 init1: 2480 opt: 2489 Z-score: 1572.9 bits: 301.1 E(85289): 7.2e-81
Smith-Waterman score: 3737; 94.8% identity (94.8% similar) in 616 aa overlap (1-584:1-616)
10 20 30 40 50 60
pF1KSD MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
130 140 150 160 170 180
190 200
pF1KSD MMTNLVMAKDRLQLLE--------------------------------SGAVPKRKDPLT
:::::::::::::::: ::::::::::::
NP_055 MMTNLVMAKDRLQLLEKMQPVLPFSKSQTDVYNDSTNLACRNGHLQSESGAVPKRKDPLT
190 200 210 220 230 240
210 220 230 240 250 260
pF1KSD HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK
250 260 270 280 290 300
270 280 290 300 310 320
pF1KSD PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL
310 320 330 340 350 360
330 340 350 360 370 380
pF1KSD PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE
370 380 390 400 410 420
390 400 410 420 430 440
pF1KSD KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV
430 440 450 460 470 480
450 460 470 480 490 500
pF1KSD LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARM
490 500 510 520 530 540
510 520 530 540 550 560
pF1KSD TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQT
550 560 570 580 590 600
570 580
pF1KSD LEAYIRWNKDFGDTTV
::::::::::::::::
NP_055 LEAYIRWNKDFGDTTV
610
>>XP_011531369 (OMIM: 182601,604277) PREDICTED: spastin (551 aa)
initn: 1990 init1: 1990 opt: 1999 Z-score: 1267.1 bits: 244.3 E(85289): 7.7e-64
Smith-Waterman score: 3247; 94.1% identity (94.1% similar) in 539 aa overlap (1-507:1-539)
10 20 30 40 50 60
pF1KSD MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNSPGGRGKKKGSGGASNPVPPRPPPPCLAPAPPAAGPAPPPESPHKRNLYYFSYPLFVG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FALLRLVAFHLGLLFVWLCQRFSRALMAAKRSSGAAPAPASASAPAPVPGGEAERVRVFH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQAFEYISIALRIDEDEKAGQKEQAVEWYKKGIEELEKGIAVIVTGQGEQCERARRLQAK
130 140 150 160 170 180
190 200
pF1KSD MMTNLVMAKDRLQLLE--------------------------------SGAVPKRKDPLT
:::::::::::::::: ::::::::::::
XP_011 MMTNLVMAKDRLQLLEKMQPVLPFSKSQTDVYNDSTNLACRNGHLQSESGAVPKRKDPLT
190 200 210 220 230 240
210 220 230 240 250 260
pF1KSD HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HTSNSLPRSKTVMKTGSAGLSGHHRAPSYSGLSMVSGVKQGSGPAPTTHKGTPKTNRTNK
250 260 270 280 290 300
270 280 290 300 310 320
pF1KSD PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSTPTTATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVIL
310 320 330 340 350 360
330 340 350 360 370 380
pF1KSD PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE
370 380 390 400 410 420
390 400 410 420 430 440
pF1KSD KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRV
430 440 450 460 470 480
450 460 470 480 490 500
pF1KSD LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARM
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLART
490 500 510 520 530 540
510 520 530 540 550 560
pF1KSD TDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQT
XP_011 KTRTGEEYVCQ
550
>>NP_001274425 (OMIM: 615383) fidgetin-like protein 1 is (563 aa)
initn: 1125 init1: 1092 opt: 1108 Z-score: 709.9 bits: 141.3 E(85289): 8.4e-33
Smith-Waterman score: 1122; 43.8% identity (74.1% similar) in 397 aa overlap (199-580:166-560)
170 180 190 200 210 220
pF1KSD EQCERARRLQAKMMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGL
: : .: . ..::: ::. . .
NP_001 CFPAACENPQRKSFYGSGTIDALSNPILNKACSKTEDNGPKEDSSLPTFKTAKEQLWVDQ
140 150 160 170 180 190
230 240 250 260 270
pF1KSD SGHHRAPSYSGLSMVSGVKQGSG-------------PAPTTHKGTPKTNRTNKP--STPT
. ... :. .. : .:::.. : : : : . . :: . ::
NP_001 QKKYHQPQRASGSSYGGVKKSLGASRSRGILGKFVPPIPKQDGGEQNGGMQCKPYGAGPT
200 210 220 230 240 250
280 290 300 310 320 330
pF1KSD TATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRP
.. . ..:.. .. .::::::.:.: :...:::: ..:: ...:::. : :::
NP_001 EPAHPVDE--RLKNLEPKMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRP
260 270 280 290 300 310
340 350 360 370 380 390
pF1KSD ELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRA
..:::::.: .:.:::::::.:::...: .:..:.::::.:::.:::::.::::::.:::
NP_001 DIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRA
320 330 340 350 360 370
400 410 420 430 440 450
pF1KSD LFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGA
:::::: ::..:::::.:::: .: .:::..:::.:::::...::. ....::.::.::
NP_001 LFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGA
380 390 400 410 420 430
460 470 480 490 500 510
pF1KSD TNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYS
::::::.:::. ::..::.:. ::. .: .. ::. :. :...:. :.....:..:
NP_001 TNRPQEIDEAARRRLVKRLYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFS
440 450 460 470 480 490
520 530 540 550 560 570
pF1KSD GSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYI
:.:.: : ..:.::::: :. .. ... ...: : :: .... .. ::::. :: :
NP_001 GADMTQLCREASLGPIRSLQTADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYE
500 510 520 530 540 550
580
pF1KSD RWNKDFGDTTV
::: ::
NP_001 NWNKTFGCGK
560
>>NP_001333488 (OMIM: 615383) fidgetin-like protein 1 is (563 aa)
initn: 1125 init1: 1092 opt: 1108 Z-score: 709.9 bits: 141.3 E(85289): 8.4e-33
Smith-Waterman score: 1122; 43.8% identity (74.1% similar) in 397 aa overlap (199-580:166-560)
170 180 190 200 210 220
pF1KSD EQCERARRLQAKMMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGL
: : .: . ..::: ::. . .
NP_001 CFPAACENPQRKSFYGSGTIDALSNPILNKACSKTEDNGPKEDSSLPTFKTAKEQLWVDQ
140 150 160 170 180 190
230 240 250 260 270
pF1KSD SGHHRAPSYSGLSMVSGVKQGSG-------------PAPTTHKGTPKTNRTNKP--STPT
. ... :. .. : .:::.. : : : : . . :: . ::
NP_001 QKKYHQPQRASGSSYGGVKKSLGASRSRGILGKFVPPIPKQDGGEQNGGMQCKPYGAGPT
200 210 220 230 240 250
280 290 300 310 320 330
pF1KSD TATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRP
.. . ..:.. .. .::::::.:.: :...:::: ..:: ...:::. : :::
NP_001 EPAHPVDE--RLKNLEPKMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRP
260 270 280 290 300 310
340 350 360 370 380 390
pF1KSD ELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRA
..:::::.: .:.:::::::.:::...: .:..:.::::.:::.:::::.::::::.:::
NP_001 DIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRA
320 330 340 350 360 370
400 410 420 430 440 450
pF1KSD LFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGA
:::::: ::..:::::.:::: .: .:::..:::.:::::...::. ....::.::.::
NP_001 LFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGA
380 390 400 410 420 430
460 470 480 490 500 510
pF1KSD TNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYS
::::::.:::. ::..::.:. ::. .: .. ::. :. :...:. :.....:..:
NP_001 TNRPQEIDEAARRRLVKRLYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFS
440 450 460 470 480 490
520 530 540 550 560 570
pF1KSD GSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYI
:.:.: : ..:.::::: :. .. ... ...: : :: .... .. ::::. :: :
NP_001 GADMTQLCREASLGPIRSLQTADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYE
500 510 520 530 540 550
580
pF1KSD RWNKDFGDTTV
::: ::
NP_001 NWNKTFGCGK
560
>>NP_001333487 (OMIM: 615383) fidgetin-like protein 1 is (563 aa)
initn: 1125 init1: 1092 opt: 1108 Z-score: 709.9 bits: 141.3 E(85289): 8.4e-33
Smith-Waterman score: 1122; 43.8% identity (74.1% similar) in 397 aa overlap (199-580:166-560)
170 180 190 200 210 220
pF1KSD EQCERARRLQAKMMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGL
: : .: . ..::: ::. . .
NP_001 CFPAACENPQRKSFYGSGTIDALSNPILNKACSKTEDNGPKEDSSLPTFKTAKEQLWVDQ
140 150 160 170 180 190
230 240 250 260 270
pF1KSD SGHHRAPSYSGLSMVSGVKQGSG-------------PAPTTHKGTPKTNRTNKP--STPT
. ... :. .. : .:::.. : : : : . . :: . ::
NP_001 QKKYHQPQRASGSSYGGVKKSLGASRSRGILGKFVPPIPKQDGGEQNGGMQCKPYGAGPT
200 210 220 230 240 250
280 290 300 310 320 330
pF1KSD TATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRP
.. . ..:.. .. .::::::.:.: :...:::: ..:: ...:::. : :::
NP_001 EPAHPVDE--RLKNLEPKMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRP
260 270 280 290 300 310
340 350 360 370 380 390
pF1KSD ELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRA
..:::::.: .:.:::::::.:::...: .:..:.::::.:::.:::::.::::::.:::
NP_001 DIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRA
320 330 340 350 360 370
400 410 420 430 440 450
pF1KSD LFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGA
:::::: ::..:::::.:::: .: .:::..:::.:::::...::. ....::.::.::
NP_001 LFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGA
380 390 400 410 420 430
460 470 480 490 500 510
pF1KSD TNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYS
::::::.:::. ::..::.:. ::. .: .. ::. :. :...:. :.....:..:
NP_001 TNRPQEIDEAARRRLVKRLYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFS
440 450 460 470 480 490
520 530 540 550 560 570
pF1KSD GSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYI
:.:.: : ..:.::::: :. .. ... ...: : :: .... .. ::::. :: :
NP_001 GADMTQLCREASLGPIRSLQTADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYE
500 510 520 530 540 550
580
pF1KSD RWNKDFGDTTV
::: ::
NP_001 NWNKTFGCGK
560
>>NP_001333489 (OMIM: 615383) fidgetin-like protein 1 is (674 aa)
initn: 1125 init1: 1092 opt: 1108 Z-score: 709.0 bits: 141.4 E(85289): 9.4e-33
Smith-Waterman score: 1122; 43.8% identity (74.1% similar) in 397 aa overlap (199-580:277-671)
170 180 190 200 210 220
pF1KSD EQCERARRLQAKMMTNLVMAKDRLQLLESGAVPKRKDPLTHTSNSLPRSKTVMKTGSAGL
: : .: . ..::: ::. . .
NP_001 CFPAACENPQRKSFYGSGTIDALSNPILNKACSKTEDNGPKEDSSLPTFKTAKEQLWVDQ
250 260 270 280 290 300
230 240 250 260 270
pF1KSD SGHHRAPSYSGLSMVSGVKQGSG-------------PAPTTHKGTPKTNRTNKP--STPT
. ... :. .. : .:::.. : : : : . . :: . ::
NP_001 QKKYHQPQRASGSSYGGVKKSLGASRSRGILGKFVPPIPKQDGGEQNGGMQCKPYGAGPT
310 320 330 340 350 360
280 290 300 310 320 330
pF1KSD TATRKKKDLKNFRNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRP
.. . ..:.. .. .::::::.:.: :...:::: ..:: ...:::. : :::
NP_001 EPAHPVDE--RLKNLEPKMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRP
370 380 390 400 410 420
340 350 360 370 380 390
pF1KSD ELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRA
..:::::.: .:.:::::::.:::...: .:..:.::::.:::.:::::.::::::.:::
NP_001 DIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRA
430 440 450 460 470 480
400 410 420 430 440 450
pF1KSD LFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSAGDDRVLVMGA
:::::: ::..:::::.:::: .: .:::..:::.:::::...::. ....::.::.::
NP_001 LFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGA
490 500 510 520 530 540
460 470 480 490 500 510
pF1KSD TNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCKQGSPLTQKELAQLARMTDGYS
::::::.:::. ::..::.:. ::. .: .. ::. :. :...:. :.....:..:
NP_001 TNRPQEIDEAARRRLVKRLYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFS
550 560 570 580 590 600
520 530 540 550 560 570
pF1KSD GSDLTALAKDAALGPIRELKPEQVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYI
:.:.: : ..:.::::: :. .. ... ...: : :: .... .. ::::. :: :
NP_001 GADMTQLCREASLGPIRSLQTADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYE
610 620 630 640 650 660
580
pF1KSD RWNKDFGDTTV
::: ::
NP_001 NWNKTFGCGK
670
584 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 04:55:08 2016 done: Thu Nov 3 04:55:10 2016
Total Scan time: 12.030 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]