Result of FASTA (omim) for
pF1KSDA1088
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1088, 1400 aa
1>>>pF1KSDA1088 1400 - 1400 aa - 1400 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.4740+/-0.000401; mu= 10.2046+/- 0.025
mean_var=209.4845+/-43.372, 0's: 0 Z-trim(119.5): 81 B-trim: 572 in 1/55
Lambda= 0.088613
statistics sampled from 33566 (33656) to 33566 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.395), width: 16
Scan time: 19.060
The best scores are: opt bits E(85289)
NP_001269938 (OMIM: 608833,615190,616373) regulato (1300) 8886 1149.9 0
NP_057518 (OMIM: 608833,615190,616373) regulator o (1219) 8253 1069.0 0
NP_116575 (OMIM: 608833,615190,616373) regulator o (1243) 7372 956.3 0
NP_001269939 (OMIM: 608833,615190,616373) regulato ( 996) 6748 876.5 0
XP_016880689 (OMIM: 114480,189960,605882,609054) P (1088) 940 134.0 5.9e-30
NP_114432 (OMIM: 114480,189960,605882,609054) Fanc (1249) 940 134.1 6.6e-30
XP_011523637 (OMIM: 114480,189960,605882,609054) P (1249) 853 122.9 1.5e-26
XP_016880692 (OMIM: 114480,189960,605882,609054) P ( 631) 588 88.8 1.4e-16
XP_016880691 (OMIM: 114480,189960,605882,609054) P ( 631) 588 88.8 1.4e-16
NP_001244074 (OMIM: 601150,613398) probable ATP-de ( 880) 547 83.7 6.7e-15
NP_085911 (OMIM: 601150,613398) probable ATP-depen ( 906) 547 83.7 6.9e-15
XP_016874421 (OMIM: 601150,613398) PREDICTED: prob ( 906) 547 83.7 6.9e-15
XP_005253390 (OMIM: 601150,613398) PREDICTED: prob ( 942) 547 83.7 7.1e-15
XP_011523642 (OMIM: 114480,189960,605882,609054) P ( 853) 537 82.4 1.6e-14
XP_011523641 (OMIM: 114480,189960,605882,609054) P ( 872) 537 82.4 1.6e-14
XP_016880690 (OMIM: 114480,189960,605882,609054) P (1088) 537 82.5 1.9e-14
XP_011523640 (OMIM: 114480,189960,605882,609054) P (1108) 537 82.5 1.9e-14
XP_011523643 (OMIM: 114480,189960,605882,609054) P ( 657) 532 81.7 2e-14
XP_011523634 (OMIM: 114480,189960,605882,609054) P (1269) 537 82.5 2.2e-14
XP_011523636 (OMIM: 114480,189960,605882,609054) P (1269) 537 82.5 2.2e-14
XP_011523635 (OMIM: 114480,189960,605882,609054) P (1269) 537 82.5 2.2e-14
XP_016874420 (OMIM: 601150,613398) PREDICTED: prob ( 931) 533 81.9 2.4e-14
XP_006719113 (OMIM: 601150,613398) PREDICTED: prob ( 967) 533 81.9 2.5e-14
XP_011523638 (OMIM: 114480,189960,605882,609054) P (1229) 532 81.9 3.3e-14
XP_016881956 (OMIM: 126340,278730,601675,610756) P ( 719) 517 79.8 8.3e-14
XP_011524913 (OMIM: 126340,278730,601675,610756) P ( 734) 517 79.8 8.4e-14
NP_000391 (OMIM: 126340,278730,601675,610756) TFII ( 760) 517 79.8 8.6e-14
XP_011523639 (OMIM: 114480,189960,605882,609054) P (1202) 467 73.6 1e-11
NP_001244073 (OMIM: 601150,613398) probable ATP-de ( 970) 386 63.1 1.1e-08
NP_689651 (OMIM: 601150,613398) probable ATP-depen ( 970) 386 63.1 1.1e-08
XP_005253388 (OMIM: 601150,613398) PREDICTED: prob (1006) 386 63.2 1.2e-08
XP_011518894 (OMIM: 601150,613398) PREDICTED: prob (1031) 386 63.2 1.2e-08
XP_016874423 (OMIM: 601150,613398) PREDICTED: prob ( 831) 376 61.8 2.5e-08
XP_011518899 (OMIM: 601150,613398) PREDICTED: prob ( 672) 230 43.1 0.0087
NP_004390 (OMIM: 601150,613398) probable ATP-depen ( 856) 232 43.4 0.0088
XP_011518897 (OMIM: 601150,613398) PREDICTED: prob ( 892) 232 43.4 0.009
XP_016874428 (OMIM: 601150,613398) PREDICTED: prob ( 743) 230 43.1 0.0094
XP_016874427 (OMIM: 601150,613398) PREDICTED: prob ( 746) 230 43.1 0.0094
>>NP_001269938 (OMIM: 608833,615190,616373) regulator of (1300 aa)
initn: 9059 init1: 8886 opt: 8886 Z-score: 6147.7 bits: 1149.9 E(85289): 0
Smith-Waterman score: 8886; 99.8% identity (100.0% similar) in 1300 aa overlap (1-1300:1-1300)
10 20 30 40 50 60
pF1KSD MPKIVLNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPKIVLNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD EHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD QVINELRNTSYRPKVCVLGSREQLCIHPEVKKQESNHLQIHLCRKKVASRSCHFYNNVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVINELRNTSYRPKVCVLGSREQLCIHPEVKKQESNHLQIHLCRKKVASRSCHFYNNVEE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD KSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD DLKGTVVIFDEAHNVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLKGTVVIFDEAHNVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD ADSPSPGLNMELEDIAKLKMILLRLEGAIDAVELPGDDSGVTKPGSYIFELFAEAQITFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADSPSPGLNMELEDIAKLKMILLRLEGAIDAVELPGDDSGVTKPGSYIFELFAEAQITFQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD TKGCILDSLDQIIQHLAGRAGVFTNTAGLQKLADIIQIVFSVDPSEGSPGSPAGLGALQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKGCILDSLDQIIQHLAGRAGVFTNTAGLQKLADIIQIVFSVDPSEGSPGSPAGLGALQS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD YKVHIHPDAGHRRTAQRSDAWSTTAARKRGKVLSYWCFSPGHSMHELVRQGVRSLILTSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YKVHIHPDAGHRRTAQRSDAWSTTAARKRGKVLSYWCFSPGHSMHELVRQGVRSLILTSG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD TLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD LGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD TISAYYARVAAPGSTGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TISAYYARVAAPGSTGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKM
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD QFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRFAFADA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRFAFADA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD RAQLPSWVRPHVRVYDNFGHVIRDVAQFFRVAERTMPAPAPRATAPSVRGEDAVSEAKSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAQLPSWVRPHVRVYDNFGHVIRDVAQFFRVAERTMPAPAPRATAPSVRGEDAVSEAKSP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD GPFFSTRKAKSLDLHVPSLKQRSSGSPAAGDPESSLCVEYEQEPVPARQRPRGLLAALEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPFFSTRKAKSLDLHVPSLKQRSSGSPAAGDPESSLCVEYEQEPVPARQRPRGLLAALEH
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD SEQRAGSPGEEQAHSCSTLSLLSEKRPAEEPRGGRKKIRLVSHPEEPVAGAQTDRAKLFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEQRAGSPGEEQAHSCSTLSLLSEKRPAEEPRGGRKKIRLVSHPEEPVAGAQTDRAKLFM
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD VAVKQELSQANFATFTQALQDYKGSDDFAALAACLGPLFAEDPKKHNLLQGFYQFVRPHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAVKQELSQANFATFTQALQDYKGSDDFAALAACLGPLFAEDPKKHNLLQGFYQFVRPHH
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD KQQFEEVCIQLTGRGCGYRPEHSIPRRQRAQPVLDPTGRTAPDPKLTVSTAAAQQLDPQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQQFEEVCIQLTGRGCGYRPEHSIPRRQRAQPVLDPTGRTAPDPKLTVSTAAAQQLDPQE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD HLNQGRPHLSPRPPPTGDPGSHPQWGSGVPRAGKQGQHAVSAYLADARRALGSAGCSQLL
:::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::
NP_001 HLNQGRPHLSPRPPPTGDPGSQPQWGSGVPRAGKQGQHAVSAYLADARRALGSAGCSQLL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD AALTAYKQDDDLDKVLAVLAALTTAKPEDFPLLHRFSMFVRPHHKQRFSQTCTDLTGRPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AALTAYKQDDDLDKVLAVLAALTTAKPEDFPLLHRFSMFVRPHHKQRFSQTCTDLTGRPY
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD PGMEPPGPQEERLAVPPVLTHRAPQPGPSRSEKTGKTQSKISSFLRQRPAGTVGAGGEDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGMEPPGPQEERLAVPPVLTHRAPQPGPSRSEKTGKTQSKISSFLRQRPAGTVGAGGEDA
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD GPSQSSGPPHGPAASEWGEPHGRDIAGQQATGAPGGPLSAGCVCQGCGAEDVVPFQCPAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSQSSGPPHGPAASEWGEPHGRDIAGQQATGAPGGPLSAGCVCQGCGAEDVVPFQCPAC
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KSD DFQRCQACWQRHLQASRMCPACHTASRKQSVMQVFWPEPHKDHEGAGGARPVAAVPGVGA
:::::::::::::::::::::::::::::::::::::::.
NP_001 DFQRCQACWQRHLQASRMCPACHTASRKQSVMQVFWPEPQ
1270 1280 1290 1300
1330 1340 1350 1360 1370 1380
pF1KSD ACPAAGAGCTRSGRNTHLPLAGRRDRGAAGVRPVPPRHLCAAAVPPRQPHDVWPVSTAPL
>>NP_057518 (OMIM: 608833,615190,616373) regulator of te (1219 aa)
initn: 8253 init1: 8253 opt: 8253 Z-score: 5710.7 bits: 1069.0 E(85289): 0
Smith-Waterman score: 8253; 99.9% identity (100.0% similar) in 1218 aa overlap (1-1218:1-1218)
10 20 30 40 50 60
pF1KSD MPKIVLNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MPKIVLNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD EHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 EHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD QVINELRNTSYRPKVCVLGSREQLCIHPEVKKQESNHLQIHLCRKKVASRSCHFYNNVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 QVINELRNTSYRPKVCVLGSREQLCIHPEVKKQESNHLQIHLCRKKVASRSCHFYNNVEE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD KSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 KSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD DLKGTVVIFDEAHNVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 DLKGTVVIFDEAHNVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD ADSPSPGLNMELEDIAKLKMILLRLEGAIDAVELPGDDSGVTKPGSYIFELFAEAQITFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ADSPSPGLNMELEDIAKLKMILLRLEGAIDAVELPGDDSGVTKPGSYIFELFAEAQITFQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD TKGCILDSLDQIIQHLAGRAGVFTNTAGLQKLADIIQIVFSVDPSEGSPGSPAGLGALQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TKGCILDSLDQIIQHLAGRAGVFTNTAGLQKLADIIQIVFSVDPSEGSPGSPAGLGALQS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD YKVHIHPDAGHRRTAQRSDAWSTTAARKRGKVLSYWCFSPGHSMHELVRQGVRSLILTSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 YKVHIHPDAGHRRTAQRSDAWSTTAARKRGKVLSYWCFSPGHSMHELVRQGVRSLILTSG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD TLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD LGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD TISAYYARVAAPGSTGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TISAYYARVAAPGSTGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKM
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD QFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRFAFADA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 QFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRFAFADA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD RAQLPSWVRPHVRVYDNFGHVIRDVAQFFRVAERTMPAPAPRATAPSVRGEDAVSEAKSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 RAQLPSWVRPHVRVYDNFGHVIRDVAQFFRVAERTMPAPAPRATAPSVRGEDAVSEAKSP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD GPFFSTRKAKSLDLHVPSLKQRSSGSPAAGDPESSLCVEYEQEPVPARQRPRGLLAALEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 GPFFSTRKAKSLDLHVPSLKQRSSGSPAAGDPESSLCVEYEQEPVPARQRPRGLLAALEH
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD SEQRAGSPGEEQAHSCSTLSLLSEKRPAEEPRGGRKKIRLVSHPEEPVAGAQTDRAKLFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SEQRAGSPGEEQAHSCSTLSLLSEKRPAEEPRGGRKKIRLVSHPEEPVAGAQTDRAKLFM
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD VAVKQELSQANFATFTQALQDYKGSDDFAALAACLGPLFAEDPKKHNLLQGFYQFVRPHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 VAVKQELSQANFATFTQALQDYKGSDDFAALAACLGPLFAEDPKKHNLLQGFYQFVRPHH
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD KQQFEEVCIQLTGRGCGYRPEHSIPRRQRAQPVLDPTGRTAPDPKLTVSTAAAQQLDPQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 KQQFEEVCIQLTGRGCGYRPEHSIPRRQRAQPVLDPTGRTAPDPKLTVSTAAAQQLDPQE
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD HLNQGRPHLSPRPPPTGDPGSHPQWGSGVPRAGKQGQHAVSAYLADARRALGSAGCSQLL
:::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::
NP_057 HLNQGRPHLSPRPPPTGDPGSQPQWGSGVPRAGKQGQHAVSAYLADARRALGSAGCSQLL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD AALTAYKQDDDLDKVLAVLAALTTAKPEDFPLLHRFSMFVRPHHKQRFSQTCTDLTGRPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 AALTAYKQDDDLDKVLAVLAALTTAKPEDFPLLHRFSMFVRPHHKQRFSQTCTDLTGRPY
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD PGMEPPGPQEERLAVPPVLTHRAPQPGPSRSEKTGKTQSKISSFLRQRPAGTVGAGGEDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 PGMEPPGPQEERLAVPPVLTHRAPQPGPSRSEKTGKTQSKISSFLRQRPAGTVGAGGEDA
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD GPSQSSGPPHGPAASEWGEPHGRDIAGQQATGAPGGPLSAGCVCQGCGAEDVVPFQCPAC
::::::::::::::::::
NP_057 GPSQSSGPPHGPAASEWGL
1210
>>NP_116575 (OMIM: 608833,615190,616373) regulator of te (1243 aa)
initn: 7372 init1: 7372 opt: 7372 Z-score: 5101.9 bits: 956.3 E(85289): 0
Smith-Waterman score: 8195; 98.0% identity (98.1% similar) in 1242 aa overlap (1-1218:1-1242)
10 20 30 40 50 60
pF1KSD MPKIVLNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 MPKIVLNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD EHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 EHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLT
70 80 90 100 110 120
130 140 150
pF1KSD QVINELRNTSYR------------------------PKVCVLGSREQLCIHPEVKKQESN
:::::::::::: ::::::::::::::::::::::::
NP_116 QVINELRNTSYRSRCRATLWVLETAPPRPTVLSPTRPKVCVLGSREQLCIHPEVKKQESN
130 140 150 160 170 180
160 170 180 190 200 210
pF1KSD HLQIHLCRKKVASRSCHFYNNVEEKSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 HLQIHLCRKKVASRSCHFYNNVEEKSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLK
190 200 210 220 230 240
220 230 240 250 260 270
pF1KSD QQADIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEESASFDLTPHDLASGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 QQADIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEESASFDLTPHDLASGL
250 260 270 280 290 300
280 290 300 310 320 330
pF1KSD DVIDQVLEEQTKAAQQGEPHPEFSADSPSPGLNMELEDIAKLKMILLRLEGAIDAVELPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 DVIDQVLEEQTKAAQQGEPHPEFSADSPSPGLNMELEDIAKLKMILLRLEGAIDAVELPG
310 320 330 340 350 360
340 350 360 370 380 390
pF1KSD DDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQIIQHLAGRAGVFTNTAGLQKLADII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 DDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQIIQHLAGRAGVFTNTAGLQKLADII
370 380 390 400 410 420
400 410 420 430 440 450
pF1KSD QIVFSVDPSEGSPGSPAGLGALQSYKVHIHPDAGHRRTAQRSDAWSTTAARKRGKVLSYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 QIVFSVDPSEGSPGSPAGLGALQSYKVHIHPDAGHRRTAQRSDAWSTTAARKRGKVLSYW
430 440 450 460 470 480
460 470 480 490 500 510
pF1KSD CFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 CFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVV
490 500 510 520 530 540
520 530 540 550 560 570
pF1KSD PRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 PRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRAR
550 560 570 580 590 600
580 590 600 610 620 630
pF1KSD DLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGSTGATFLAVCRGKASEGLDFSDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 DLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGSTGATFLAVCRGKASEGLDFSDT
610 620 630 640 650 660
640 650 660 670 680 690
pF1KSD NGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 NGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIG
670 680 690 700 710 720
700 710 720 730 740 750
pF1KSD RVIRHRQDYGAVFLCDHRFAFADARAQLPSWVRPHVRVYDNFGHVIRDVAQFFRVAERTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 RVIRHRQDYGAVFLCDHRFAFADARAQLPSWVRPHVRVYDNFGHVIRDVAQFFRVAERTM
730 740 750 760 770 780
760 770 780 790 800 810
pF1KSD PAPAPRATAPSVRGEDAVSEAKSPGPFFSTRKAKSLDLHVPSLKQRSSGSPAAGDPESSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 PAPAPRATAPSVRGEDAVSEAKSPGPFFSTRKAKSLDLHVPSLKQRSSGSPAAGDPESSL
790 800 810 820 830 840
820 830 840 850 860 870
pF1KSD CVEYEQEPVPARQRPRGLLAALEHSEQRAGSPGEEQAHSCSTLSLLSEKRPAEEPRGGRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 CVEYEQEPVPARQRPRGLLAALEHSEQRAGSPGEEQAHSCSTLSLLSEKRPAEEPRGGRK
850 860 870 880 890 900
880 890 900 910 920 930
pF1KSD KIRLVSHPEEPVAGAQTDRAKLFMVAVKQELSQANFATFTQALQDYKGSDDFAALAACLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 KIRLVSHPEEPVAGAQTDRAKLFMVAVKQELSQANFATFTQALQDYKGSDDFAALAACLG
910 920 930 940 950 960
940 950 960 970 980 990
pF1KSD PLFAEDPKKHNLLQGFYQFVRPHHKQQFEEVCIQLTGRGCGYRPEHSIPRRQRAQPVLDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 PLFAEDPKKHNLLQGFYQFVRPHHKQQFEEVCIQLTGRGCGYRPEHSIPRRQRAQPVLDP
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KSD TGRTAPDPKLTVSTAAAQQLDPQEHLNQGRPHLSPRPPPTGDPGSHPQWGSGVPRAGKQG
:::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::
NP_116 TGRTAPDPKLTVSTAAAQQLDPQEHLNQGRPHLSPRPPPTGDPGSQPQWGSGVPRAGKQG
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KSD QHAVSAYLADARRALGSAGCSQLLAALTAYKQDDDLDKVLAVLAALTTAKPEDFPLLHRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 QHAVSAYLADARRALGSAGCSQLLAALTAYKQDDDLDKVLAVLAALTTAKPEDFPLLHRF
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KSD SMFVRPHHKQRFSQTCTDLTGRPYPGMEPPGPQEERLAVPPVLTHRAPQPGPSRSEKTGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 SMFVRPHHKQRFSQTCTDLTGRPYPGMEPPGPQEERLAVPPVLTHRAPQPGPSRSEKTGK
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210 1220 1230
pF1KSD TQSKISSFLRQRPAGTVGAGGEDAGPSQSSGPPHGPAASEWGEPHGRDIAGQQATGAPGG
::::::::::::::::::::::::::::::::::::::::::
NP_116 TQSKISSFLRQRPAGTVGAGGEDAGPSQSSGPPHGPAASEWGL
1210 1220 1230 1240
1240 1250 1260 1270 1280 1290
pF1KSD PLSAGCVCQGCGAEDVVPFQCPACDFQRCQACWQRHLQASRMCPACHTASRKQSVMQVFW
>>NP_001269939 (OMIM: 608833,615190,616373) regulator of (996 aa)
initn: 6748 init1: 6748 opt: 6748 Z-score: 4672.1 bits: 876.5 E(85289): 0
Smith-Waterman score: 6748; 99.9% identity (100.0% similar) in 995 aa overlap (224-1218:1-995)
200 210 220 230 240 250
pF1KSD IEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAH
::::::::::::::::::::::::::::::
NP_001 MPYNYLLDAKSRRAHNIDLKGTVVIFDEAH
10 20 30
260 270 280 290 300 310
pF1KSD NVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSADSPSPGLNMELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSADSPSPGLNMELE
40 50 60 70 80 90
320 330 340 350 360 370
pF1KSD DIAKLKMILLRLEGAIDAVELPGDDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIAKLKMILLRLEGAIDAVELPGDDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQII
100 110 120 130 140 150
380 390 400 410 420 430
pF1KSD QHLAGRAGVFTNTAGLQKLADIIQIVFSVDPSEGSPGSPAGLGALQSYKVHIHPDAGHRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QHLAGRAGVFTNTAGLQKLADIIQIVFSVDPSEGSPGSPAGLGALQSYKVHIHPDAGHRR
160 170 180 190 200 210
440 450 460 470 480 490
pF1KSD TAQRSDAWSTTAARKRGKVLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAQRSDAWSTTAARKRGKVLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQ
220 230 240 250 260 270
500 510 520 530 540 550
pF1KSD IPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVP
280 290 300 310 320 330
560 570 580 590 600 610
pF1KSD YGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPG
340 350 360 370 380 390
620 630 640 650 660 670
pF1KSD STGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAG
400 410 420 430 440 450
680 690 700 710 720 730
pF1KSD GQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRFAFADARAQLPSWVRPHVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRFAFADARAQLPSWVRPHVR
460 470 480 490 500 510
740 750 760 770 780 790
pF1KSD VYDNFGHVIRDVAQFFRVAERTMPAPAPRATAPSVRGEDAVSEAKSPGPFFSTRKAKSLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYDNFGHVIRDVAQFFRVAERTMPAPAPRATAPSVRGEDAVSEAKSPGPFFSTRKAKSLD
520 530 540 550 560 570
800 810 820 830 840 850
pF1KSD LHVPSLKQRSSGSPAAGDPESSLCVEYEQEPVPARQRPRGLLAALEHSEQRAGSPGEEQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHVPSLKQRSSGSPAAGDPESSLCVEYEQEPVPARQRPRGLLAALEHSEQRAGSPGEEQA
580 590 600 610 620 630
860 870 880 890 900 910
pF1KSD HSCSTLSLLSEKRPAEEPRGGRKKIRLVSHPEEPVAGAQTDRAKLFMVAVKQELSQANFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSCSTLSLLSEKRPAEEPRGGRKKIRLVSHPEEPVAGAQTDRAKLFMVAVKQELSQANFA
640 650 660 670 680 690
920 930 940 950 960 970
pF1KSD TFTQALQDYKGSDDFAALAACLGPLFAEDPKKHNLLQGFYQFVRPHHKQQFEEVCIQLTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TFTQALQDYKGSDDFAALAACLGPLFAEDPKKHNLLQGFYQFVRPHHKQQFEEVCIQLTG
700 710 720 730 740 750
980 990 1000 1010 1020 1030
pF1KSD RGCGYRPEHSIPRRQRAQPVLDPTGRTAPDPKLTVSTAAAQQLDPQEHLNQGRPHLSPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGCGYRPEHSIPRRQRAQPVLDPTGRTAPDPKLTVSTAAAQQLDPQEHLNQGRPHLSPRP
760 770 780 790 800 810
1040 1050 1060 1070 1080 1090
pF1KSD PPTGDPGSHPQWGSGVPRAGKQGQHAVSAYLADARRALGSAGCSQLLAALTAYKQDDDLD
::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPTGDPGSQPQWGSGVPRAGKQGQHAVSAYLADARRALGSAGCSQLLAALTAYKQDDDLD
820 830 840 850 860 870
1100 1110 1120 1130 1140 1150
pF1KSD KVLAVLAALTTAKPEDFPLLHRFSMFVRPHHKQRFSQTCTDLTGRPYPGMEPPGPQEERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVLAVLAALTTAKPEDFPLLHRFSMFVRPHHKQRFSQTCTDLTGRPYPGMEPPGPQEERL
880 890 900 910 920 930
1160 1170 1180 1190 1200 1210
pF1KSD AVPPVLTHRAPQPGPSRSEKTGKTQSKISSFLRQRPAGTVGAGGEDAGPSQSSGPPHGPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVPPVLTHRAPQPGPSRSEKTGKTQSKISSFLRQRPAGTVGAGGEDAGPSQSSGPPHGPA
940 950 960 970 980 990
1220 1230 1240 1250 1260 1270
pF1KSD ASEWGEPHGRDIAGQQATGAPGGPLSAGCVCQGCGAEDVVPFQCPACDFQRCQACWQRHL
:::::
NP_001 ASEWGL
>>XP_016880689 (OMIM: 114480,189960,605882,609054) PREDI (1088 aa)
initn: 1077 init1: 301 opt: 940 Z-score: 658.7 bits: 134.0 E(85289): 5.9e-30
Smith-Waterman score: 1155; 32.1% identity (61.9% similar) in 761 aa overlap (104-831:80-796)
80 90 100 110 120 130
pF1KSD ERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLTQVINELRNTSYRP
. :::: ...:::.:..:. ::: :.:
XP_016 PGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSG
50 60 70 80 90 100
140 150 160 170 180
pF1KSD -KVCVLGSREQLCIHPEVKKQ-ESNHLQIHLCRKKVASRSCHFYNNVEEKSLEQELAS--
. .:.::.. :.:::: . . :. ..: : ..::.::..:.. : .. : .
XP_016 VPMTILSSRDHTCVHPEVVGNFNRNEKCMELLDGK-NGKSCYFYHGVHKISDQHTLQTFQ
110 120 130 140 150 160
190 200 210 220 230 240
pF1KSD ---PILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLKGTV
:::.::. :.: ..:::: .:.: :.::::: ::::::::. :.. ...:: :
XP_016 GMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQV
170 180 190 200 210 220
250 260 270 280 290 300
pF1KSD VIFDEAHNVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSA-----
::.:::::.: .::::...: .: . : .:...... . .. ::
XP_016 VILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRK-KDHEPLRAVCCSLINW
230 240 250 260 270 280
310 320 330 340 350
pF1KSD -DSPSPGL-NMELEDIAKL----KMILLRLEGAIDAVELP---GDDSGVTKPGSYIFELF
.. . : . . :. :. .:.: . .: .. .: : :.: . : ..
XP_016 LEANAEYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIY
290 300 310 320 330 340
360 370 380 390 400
pF1KSD A-----EAQITFQTKGCILDSLDQIIQHLAGRAGVFTNTAGLQKLADIIQIVFSVDPSEG
. :. . . .: .: .....: . . :.. :.: :: ..: ..
XP_016 GKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADD---YKIA--IQQTYSWT-NQI
350 360 370 380 390 400
410 420 430 440 450 460
pF1KSD SPGSPAGLGALQSYKVHIHPDAGHRRTAQRSDAWSTTAARKRGKVLSYWCFSPGHSMHEL
. .. :: .: . : .:. :. ::.. ::..::..:. .. .
XP_016 DISDKNGLLVLPKNK---------KRSRQK------TAVH----VLNFWCLNPAVAFSD-
410 420 430 440
470 480 490 500 510 520
pF1KSD VRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSS
. :....::::::.:..::. :. . : . :: ::: . :.:::.. :: : .: .
XP_016 INGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCA
450 460 470 480 490 500
530 540 550 560 570 580
pF1KSD AFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKP
.:. . : . .: : .. ..: :.: :.::: ..:: : : . : ...: .:
XP_016 TFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKT
510 520 530 540 550 560
590 600 610 620 630 640
pF1KSD LFVEPRS--KGSFSETISAYYARVAAPG-STGATFLAVCRGKASEGLDFSDTNGRGVIVT
..:::.. : .:.: ...:: . : . :: ..::::::.:::::::: :.:.::.
XP_016 VIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITI
570 580 590 600 610 620
650 660 670 680 690 700
pF1KSD GLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQD
:.:.: : .: :: :. :. . : .: :..::. :: ::.:::.:: ::::.:
XP_016 GIPFPNVKDLQVELKRQYNDHHSKLRG----LLPGRQWYEIQAYRALNQALGRCIRHRND
630 640 650 660 670
710 720 730 740 750 760
pF1KSD YGAVFLCDHRFAFADAR--AQLPSWVRPHVRVYDNFGHVIRDVAQFFRVAERTMPAPAPR
.::..: : :: .: . : .::: ... ...: .....:.: . .... .
XP_016 WGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNV----
680 690 700 710 720 730
770 780 790 800 810 820
pF1KSD ATAPSVRGEDAVSEAKSPGPFFSTRKAKSLDLHVPSLKQRSSGSPAAG-DPESSLCVEYE
:.. . ... .: : . . : : :. : :: . :...::.
XP_016 ----SIKDRTNIQDNESTLEVTSLKYSTSPYL----LEAASHLSPENFVEDEAKICVQEL
740 750 760 770 780
830 840 850 860 870 880
pF1KSD QEP-VPARQRPRGLLAALEHSEQRAGSPGEEQAHSCSTLSLLSEKRPAEEPRGGRKKIRL
: : . ... :
XP_016 QCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFN
790 800 810 820 830 840
>>NP_114432 (OMIM: 114480,189960,605882,609054) Fanconi (1249 aa)
initn: 1248 init1: 301 opt: 940 Z-score: 657.9 bits: 134.1 E(85289): 6.6e-30
Smith-Waterman score: 1155; 32.1% identity (61.9% similar) in 761 aa overlap (104-831:241-957)
80 90 100 110 120 130
pF1KSD ERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLTQVINELRNTSYRP
. :::: ...:::.:..:. ::: :.:
NP_114 PGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSG
220 230 240 250 260 270
140 150 160 170 180
pF1KSD -KVCVLGSREQLCIHPEVKKQ-ESNHLQIHLCRKKVASRSCHFYNNVEEKSLEQELAS--
. .:.::.. :.:::: . . :. ..: : ..::.::..:.. : .. : .
NP_114 VPMTILSSRDHTCVHPEVVGNFNRNEKCMELLDGK-NGKSCYFYHGVHKISDQHTLQTFQ
280 290 300 310 320
190 200 210 220 230 240
pF1KSD ---PILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLKGTV
:::.::. :.: ..:::: .:.: :.::::: ::::::::. :.. ...:: :
NP_114 GMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQV
330 340 350 360 370 380
250 260 270 280 290 300
pF1KSD VIFDEAHNVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSA-----
::.:::::.: .::::...: .: . : .:...... . .. ::
NP_114 VILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRK-KDHEPLRAVCCSLINW
390 400 410 420 430 440
310 320 330 340 350
pF1KSD -DSPSPGL-NMELEDIAKL----KMILLRLEGAIDAVELP---GDDSGVTKPGSYIFELF
.. . : . . :. :. .:.: . .: .. .: : :.: . : ..
NP_114 LEANAEYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIY
450 460 470 480 490 500
360 370 380 390 400
pF1KSD A-----EAQITFQTKGCILDSLDQIIQHLAGRAGVFTNTAGLQKLADIIQIVFSVDPSEG
. :. . . .: .: .....: . . :.. :.: :: ..: ..
NP_114 GKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADD---YKIA--IQQTYSWT-NQI
510 520 530 540 550 560
410 420 430 440 450 460
pF1KSD SPGSPAGLGALQSYKVHIHPDAGHRRTAQRSDAWSTTAARKRGKVLSYWCFSPGHSMHEL
. .. :: .: . : .:. :. ::.. ::..::..:. .. .
NP_114 DISDKNGLLVLPKNK---------KRSRQK------TAVH----VLNFWCLNPAVAFSD-
570 580 590 600
470 480 490 500 510 520
pF1KSD VRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSS
. :....::::::.:..::. :. . : . :: ::: . :.:::.. :: : .: .
NP_114 INGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCA
610 620 630 640 650 660
530 540 550 560 570 580
pF1KSD AFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKP
.:. . : . .: : .. ..: :.: :.::: ..:: : : . : ...: .:
NP_114 TFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKT
670 680 690 700 710 720
590 600 610 620 630 640
pF1KSD LFVEPRS--KGSFSETISAYYARVAAPG-STGATFLAVCRGKASEGLDFSDTNGRGVIVT
..:::.. : .:.: ...:: . : . :: ..::::::.:::::::: :.:.::.
NP_114 VIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITI
730 740 750 760 770 780
650 660 670 680 690 700
pF1KSD GLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQD
:.:.: : .: :: :. :. . : .: :..::. :: ::.:::.:: ::::.:
NP_114 GIPFPNVKDLQVELKRQYNDHHSKLRG----LLPGRQWYEIQAYRALNQALGRCIRHRND
790 800 810 820 830
710 720 730 740 750 760
pF1KSD YGAVFLCDHRFAFADAR--AQLPSWVRPHVRVYDNFGHVIRDVAQFFRVAERTMPAPAPR
.::..: : :: .: . : .::: ... ...: .....:.: . .... .
NP_114 WGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNV----
840 850 860 870 880 890
770 780 790 800 810 820
pF1KSD ATAPSVRGEDAVSEAKSPGPFFSTRKAKSLDLHVPSLKQRSSGSPAAG-DPESSLCVEYE
:.. . ... .: : . . : : :. : :: . :...::.
NP_114 ----SIKDRTNIQDNESTLEVTSLKYSTSPYL----LEAASHLSPENFVEDEAKICVQEL
900 910 920 930 940
830 840 850 860 870 880
pF1KSD QEP-VPARQRPRGLLAALEHSEQRAGSPGEEQAHSCSTLSLLSEKRPAEEPRGGRKKIRL
: : . ... :
NP_114 QCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFN
950 960 970 980 990 1000
>>XP_011523637 (OMIM: 114480,189960,605882,609054) PREDI (1249 aa)
initn: 1159 init1: 301 opt: 853 Z-score: 597.8 bits: 122.9 E(85289): 1.5e-26
Smith-Waterman score: 1068; 31.5% identity (61.0% similar) in 762 aa overlap (104-831:241-957)
80 90 100 110 120 130
pF1KSD ERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLTQVINELRNTSYRP
. :::: ...:::.:..:. ::: :.:
XP_011 PGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSG
220 230 240 250 260 270
140 150 160 170 180
pF1KSD -KVCVLGSREQLCIHPEVKKQ-ESNHLQIHLCRKKVASRSCHFYNNVEEKSLEQELAS--
. .:.::.. :.:::: . . :. ..: : ..::.::..:.. : .. : .
XP_011 VPMTILSSRDHTCVHPEVVGNFNRNEKCMELLDGK-NGKSCYFYHGVHKISDQHTLQTFQ
280 290 300 310 320
190 200 210 220 230 240
pF1KSD ---PILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLKGTV
:::.::. :.: ..:::: .:.: :.::::: ::::::::. :.. ...:: :
XP_011 GMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQV
330 340 350 360 370 380
250 260 270 280 290 300
pF1KSD VIFDEAHNVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSA-----
::.:::::.: .::::...: .: . : .:...... . .. ::
XP_011 VILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRK-KDHEPLRAVCCSLINW
390 400 410 420 430 440
310 320 330 340 350
pF1KSD -DSPSPGL-NMELEDIAKL----KMILLRLEGAIDAVELP---GDDSGVTKPGSYIFELF
.. . : . . :. :. .:.: . .: .. .: : :.: . : ..
XP_011 LEANAEYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIY
450 460 470 480 490 500
360 370 380 390 400
pF1KSD A-----EAQITFQTKGCILDSLDQIIQHLAGRAGVFTNTAGLQKLADIIQIVFSVDPSEG
. :. . . .: .: .....: . . :.. :.: :: ..: ..
XP_011 GKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADD---YKIA--IQQTYSWT-NQI
510 520 530 540 550 560
410 420 430 440 450 460
pF1KSD SPGSPAGLGALQSYKVHIHPDAGHRRTAQRSDAWSTTAARKRGKVLSYWCFSPGHSMHEL
. .. :: .: . : .:. :. ::.. ::..::..:. .. .
XP_011 DISDKNGLLVLPKNK---------KRSRQK------TAVH----VLNFWCLNPAVAFSD-
570 580 590 600
470 480 490 500 510 520
pF1KSD VRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVG-VVPRGPDGAQLS
. :....::::::.:..::. :. . : . :: ::: . :: . . :..:
XP_011 INGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQIMSSKFIIYVVACARVS
610 620 630 640 650 660
530 540 550 560 570 580
pF1KSD SAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALK
: . . : . .: : .. ..: :.: :.::: ..:: : : . : ...: .:
XP_011 S-LKNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVK
670 680 690 700 710 720
590 600 610 620 630 640
pF1KSD PLFVEPRS--KGSFSETISAYYARVAAPG-STGATFLAVCRGKASEGLDFSDTNGRGVIV
..:::.. : .:.: ...:: . : . :: ..::::::.:::::::: :.:.::.
XP_011 TVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVIT
730 740 750 760 770 780
650 660 670 680 690 700
pF1KSD TGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQ
:.:.: : .: :: :. :. . : .: :..::. :: ::.:::.:: ::::.
XP_011 IGIPFPNVKDLQVELKRQYNDHHSKLRG----LLPGRQWYEIQAYRALNQALGRCIRHRN
790 800 810 820 830
710 720 730 740 750 760
pF1KSD DYGAVFLCDHRFAFADAR--AQLPSWVRPHVRVYDNFGHVIRDVAQFFRVAERTMPAPAP
:.::..: : :: .: . : .::: ... ...: .....:.: . .... .
XP_011 DWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNV---
840 850 860 870 880 890
770 780 790 800 810 820
pF1KSD RATAPSVRGEDAVSEAKSPGPFFSTRKAKSLDLHVPSLKQRSSGSPAAG-DPESSLCVEY
:.. . ... .: : . . : : :. : :: . :...::.
XP_011 -----SIKDRTNIQDNESTLEVTSLKYSTSPYL----LEAASHLSPENFVEDEAKICVQE
900 910 920 930 940
830 840 850 860 870
pF1KSD EQEP-VPARQRPRGLLAALEHSEQRAGSPGEEQAHSCSTLSLLSEKRPAEEPRGGRKKIR
: : . ... :
XP_011 LQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSF
950 960 970 980 990 1000
>>XP_016880692 (OMIM: 114480,189960,605882,609054) PREDI (631 aa)
initn: 517 init1: 191 opt: 588 Z-score: 418.7 bits: 88.8 E(85289): 1.4e-16
Smith-Waterman score: 601; 33.8% identity (63.1% similar) in 328 aa overlap (511-831:28-339)
490 500 510 520 530 540
pF1KSD TLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSS
.:::.. :: : .: ..:. . : .
XP_016 MNSSEGRIHVPRFQVAFFRDTDKYGKLVWVGTIGSGPKGRNLCATFQNTETFEFQDE
10 20 30 40 50
550 560 570 580 590
pF1KSD LGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRS--KGSF
.: : .. ..: :.: :.::: ..:: : : . : ...: .: ..:::.. : .:
XP_016 VGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNF
60 70 80 90 100 110
600 610 620 630 640 650
pF1KSD SETISAYYARVAAPG-STGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVV
.: ...:: . : . :: ..::::::.:::::::: :.:.::. :.:.: : .:
XP_016 DELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVE
120 130 140 150 160 170
660 670 680 690 700 710
pF1KSD LKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRFAF
:: :. :. . : .: :..::. :: ::.:::.:: ::::.:.::..: : ::
XP_016 LKRQYNDHHSKLRG----LLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRN
180 190 200 210 220 230
720 730 740 750 760 770
pF1KSD ADAR--AQLPSWVRPHVRVYDNFGHVIRDVAQFFRVAERTMPAPAPRATAPSVRGEDAVS
.: . : .::: ... ...: .....:.: . .... . :.. . ..
XP_016 NPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNV--------SIKDRTNIQ
240 250 260 270 280
780 790 800 810 820 830
pF1KSD EAKSPGPFFSTRKAKSLDLHVPSLKQRSSGSPAAG-DPESSLCVEYEQEP-VPARQRPRG
. .: : . . : : :. : :: . :...::. : : . ... :
XP_016 DNESTLEVTSLKYSTSPYL----LEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLP
290 300 310 320 330 340
840 850 860 870 880 890
pF1KSD LLAALEHSEQRAGSPGEEQAHSCSTLSLLSEKRPAEEPRGGRKKIRLVSHPEEPVAGAQT
XP_016 SSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKA
350 360 370 380 390 400
>>XP_016880691 (OMIM: 114480,189960,605882,609054) PREDI (631 aa)
initn: 517 init1: 191 opt: 588 Z-score: 418.7 bits: 88.8 E(85289): 1.4e-16
Smith-Waterman score: 601; 33.8% identity (63.1% similar) in 328 aa overlap (511-831:28-339)
490 500 510 520 530 540
pF1KSD TLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSS
.:::.. :: : .: ..:. . : .
XP_016 MNSSEGRIHVPRFQVAFFRDTDKYGKLVWVGTIGSGPKGRNLCATFQNTETFEFQDE
10 20 30 40 50
550 560 570 580 590
pF1KSD LGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRS--KGSF
.: : .. ..: :.: :.::: ..:: : : . : ...: .: ..:::.. : .:
XP_016 VGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNF
60 70 80 90 100 110
600 610 620 630 640 650
pF1KSD SETISAYYARVAAPG-STGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVV
.: ...:: . : . :: ..::::::.:::::::: :.:.::. :.:.: : .:
XP_016 DELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVE
120 130 140 150 160 170
660 670 680 690 700 710
pF1KSD LKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRFAF
:: :. :. . : .: :..::. :: ::.:::.:: ::::.:.::..: : ::
XP_016 LKRQYNDHHSKLRG----LLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRN
180 190 200 210 220 230
720 730 740 750 760 770
pF1KSD ADAR--AQLPSWVRPHVRVYDNFGHVIRDVAQFFRVAERTMPAPAPRATAPSVRGEDAVS
.: . : .::: ... ...: .....:.: . .... . :.. . ..
XP_016 NPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNV--------SIKDRTNIQ
240 250 260 270 280
780 790 800 810 820 830
pF1KSD EAKSPGPFFSTRKAKSLDLHVPSLKQRSSGSPAAG-DPESSLCVEYEQEP-VPARQRPRG
. .: : . . : : :. : :: . :...::. : : . ... :
XP_016 DNESTLEVTSLKYSTSPYL----LEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLP
290 300 310 320 330 340
840 850 860 870 880 890
pF1KSD LLAALEHSEQRAGSPGEEQAHSCSTLSLLSEKRPAEEPRGGRKKIRLVSHPEEPVAGAQT
XP_016 SSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKA
350 360 370 380 390 400
>>NP_001244074 (OMIM: 601150,613398) probable ATP-depend (880 aa)
initn: 903 init1: 209 opt: 547 Z-score: 388.4 bits: 83.7 E(85289): 6.7e-15
Smith-Waterman score: 826; 27.8% identity (56.9% similar) in 698 aa overlap (106-750:200-874)
80 90 100 110 120 130
pF1KSD AQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLTQVINELRNTSYRPKV
: :: : :::::::.: ..:.... . :
NP_001 ELVLAEYESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDV
170 180 190 200 210 220
140 150 160 170
pF1KSD CV--LGSREQLCIHPEVKKQESNHLQIHLC---------------------RKKVASRSC
. ::::..::.. .::. : .: : :.. . .:
NP_001 RLVSLGSRQNLCVNEDVKSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAAC
230 240 250 260 270 280
180 190 200 210 220 230
pF1KSD HFYNNVEEKSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDA
:::. . :..: . . :.:.:. :.. :.:::: :: :... .::..:: :
NP_001 PFYNHEQMGLLRDEALAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHA
290 300 310 320 330 340
240 250 260 270 280 290
pF1KSD KSRRAHNIDLKGTVVIFDEAHNVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQ
.:.: .: :. :::.:::::. : .:. .. ....:
NP_001 ATRQAAGIRLQDQVVIIDEAHNLI--------------DTITGMHSVE------VSGSQL
350 360 370 380
300 310 320 330 340
pF1KSD GEPHPEFSADSPSPGLNMELEDIAKLKMILLRLEGAIDA----VELPGDDSGVTKPGSY-
. : .. : .. ... ::.:: :: . . .. . ..... :.
NP_001 CQAHSQLLQYVERYGKRLKAKNLMYLKQILYLLEKFVAVLGGNIKQNPNTQSLSQTGTEL
390 400 410 420 430 440
350 360 370 380 390 400
pF1KSD --IFELFAEAQIT----FQT-KGCILDSLDQIIQHLAGRAGVFTNTAGLQKLADIIQIVF
: ... ..:: :.. . : . ... . .. : :. .. ::: . :..
NP_001 KTINDFLFQSQIDNINLFKVQRYCEKSMISRKLFGFTERYGAVFSSREQPKLAGFQQFLQ
450 460 470 480 490 500
410 420 430 440 450
pF1KSD SVDP--SEG--SPGSPAGLGALQ--SYKVHIHPDAGHRRTA-QRSDAWSTTAARKRGKVL
:..: .:. .:.. . ..:. : .::. . :: : . . . . ..:
NP_001 SLQPRTTEALAAPADESQASTLRPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTL
510 520 530 540 550 560
460 470 480 490 500
pF1KSD SYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEM------QIPFPVCLENPHIID
.. ..:. . ..:.. :......::. :::.: .. . : . :.:
NP_001 KFLLLNPAVHFAQVVKE-CRAVVIAGGTMQPVSDFRQQLLACAGVEAERVVEFSCGHVIP
570 580 590 600 610 620
510 520 530 540 550 560
pF1KSD KHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVME
.: :. : .. : .:..: . .. .:. : :. ::: :.. ::::: ..
NP_001 PDNILPLVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVVPGGVVCFFPSYEYLR
630 640 650 660 670 680
570 580 590 600 610 620
pF1KSD KSLEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGS-----TGATFLAV
. :. : .. : : .: ::.: . ... :: . : :. ::: .:.:
NP_001 QVHAHWEKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCIQACGQERGQVTGALLLSV
690 700 710 720 730 740
630 640 650 660 670 680
pF1KSD CRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEW
:: :::..:::. :: :...:.:.: . .. :: .::. . : :: :.
NP_001 VGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLDQTLPR--APGQAPPGKAL
750 760 770 780 790 800
690 700 710 720 730 740
pF1KSD YRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRFAFADARAQLPSWVRPHVRVYDNFGHVI
.. .::::.:::.:::..:...: : :.:.: . :.::.:.: .:.: .:: .:
NP_001 VENLCMKAVNQSIGRAIRHQKDFASVVLLDQRYARPPVLAKLPAWIRARVEVKATFGPAI
810 820 830 840 850 860
750 760 770 780 790 800
pF1KSD RDVAQFFRVAERTMPAPAPRATAPSVRGEDAVSEAKSPGPFFSTRKAKSLDLHVPSLKQR
: .: :
NP_001 AAVQKFHREKSASS
870 880
1400 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 04:56:31 2016 done: Thu Nov 3 04:56:34 2016
Total Scan time: 19.060 Total Display time: 0.370
Function used was FASTA [36.3.4 Apr, 2011]