Result of FASTA (omim) for
pF1KSDA1098
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1098, 493 aa
1>>>pF1KSDA1098 493 - 493 aa - 493 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1842+/-0.000428; mu= 15.7987+/- 0.026
mean_var=203.7612+/-44.692, 0's: 0 Z-trim(117.2): 235 B-trim: 1395 in 1/57
Lambda= 0.089849
statistics sampled from 28755 (29076) to 28755 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.341), width: 16
Scan time: 10.140
The best scores are: opt bits E(85289)
NP_741983 (OMIM: 617007) tripartite motif-containi ( 493) 3451 460.6 4.6e-129
XP_011542755 (OMIM: 617007) PREDICTED: tripartite ( 343) 2351 317.8 3.2e-86
XP_005273509 (OMIM: 617007) PREDICTED: tripartite ( 298) 1778 243.4 6.7e-64
NP_001291424 (OMIM: 617007) tripartite motif-conta ( 266) 1087 153.8 5.8e-37
NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 670 100.1 1.5e-20
XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 555) 670 100.2 1.6e-20
NP_060677 (OMIM: 616755) E3 ubiquitin-protein liga ( 475) 663 99.2 2.8e-20
NP_892030 (OMIM: 616017) E3 ubiquitin-protein liga ( 500) 643 96.6 1.7e-19
NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 642 96.4 1.8e-19
NP_001268380 (OMIM: 612548) E3 ubiquitin-protein l ( 487) 596 90.5 1.2e-17
NP_835226 (OMIM: 612548) E3 ubiquitin-protein liga ( 487) 596 90.5 1.2e-17
XP_011514091 (OMIM: 612548) PREDICTED: E3 ubiquiti ( 486) 595 90.4 1.3e-17
NP_001268379 (OMIM: 612548) E3 ubiquitin-protein l ( 486) 595 90.4 1.3e-17
XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 572 87.4 9.9e-17
XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 572 87.4 9.9e-17
NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 572 87.4 9.9e-17
NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 572 87.4 9.9e-17
XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 572 87.4 9.9e-17
NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 568 86.9 1.4e-16
NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475) 557 85.4 3.8e-16
XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 512 79.6 2.1e-14
XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 478 75.2 4.6e-13
NP_001008275 (OMIM: 613288) tripartite motif-conta ( 477) 464 73.4 1.6e-12
NP_006769 (OMIM: 605701) tripartite motif-containi ( 481) 448 71.3 6.9e-12
NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 438 70.0 1.7e-11
NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 438 70.1 1.8e-11
NP_291027 (OMIM: 610530) E3 ubiquitin-protein liga ( 630) 432 69.4 3.4e-11
NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 416 67.2 1.2e-10
NP_001186502 (OMIM: 606559) E3 ubiquitin-protein l ( 494) 413 66.8 1.6e-10
XP_011512524 (OMIM: 605701) PREDICTED: tripartite ( 499) 412 66.7 1.8e-10
XP_011512525 (OMIM: 605701) PREDICTED: tripartite ( 499) 412 66.7 1.8e-10
XP_011512523 (OMIM: 605701) PREDICTED: tripartite ( 499) 412 66.7 1.8e-10
NP_542783 (OMIM: 616017) E3 ubiquitin-protein liga ( 341) 404 65.4 3e-10
NP_439893 (OMIM: 605701) tripartite motif-containi ( 395) 398 64.7 5.5e-10
NP_001317412 (OMIM: 616755) E3 ubiquitin-protein l ( 354) 394 64.1 7.4e-10
XP_006714995 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 520) 393 64.2 1e-09
XP_006714992 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 543) 393 64.3 1e-09
NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 392 64.1 1.1e-09
XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391) 386 63.1 1.6e-09
NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 385 62.9 1.6e-09
NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488) 384 63.0 2.2e-09
NP_067629 (OMIM: 605684) tripartite motif-containi ( 488) 384 63.0 2.2e-09
NP_001288073 (OMIM: 616017) E3 ubiquitin-protein l ( 296) 379 62.1 2.6e-09
NP_963921 (OMIM: 610530) E3 ubiquitin-protein liga ( 518) 380 62.5 3.2e-09
XP_006714993 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 541) 380 62.6 3.3e-09
XP_006714994 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 525) 375 61.9 5.1e-09
XP_016857119 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 544) 373 61.7 6.2e-09
XP_005249433 (OMIM: 600830) PREDICTED: tripartite ( 539) 364 60.5 1.4e-08
XP_005249434 (OMIM: 600830) PREDICTED: tripartite ( 539) 364 60.5 1.4e-08
NP_001229712 (OMIM: 600830) tripartite motif-conta ( 539) 364 60.5 1.4e-08
>>NP_741983 (OMIM: 617007) tripartite motif-containing p (493 aa)
initn: 3451 init1: 3451 opt: 3451 Z-score: 2438.1 bits: 460.6 E(85289): 4.6e-129
Smith-Waterman score: 3451; 100.0% identity (100.0% similar) in 493 aa overlap (1-493:1-493)
10 20 30 40 50 60
pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LQMEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRVWKKMLASVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 LQMEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRVWKKMLASVE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD SVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFSQGSHAWEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 SVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFSQGSHAWEV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD ALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 ALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD VLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEVRPYFYLGGARGAGPPEPLRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 VLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEVRPYFYLGGARGAGPPEPLRI
430 440 450 460 470 480
490
pF1KSD CPLHISVKEELDG
:::::::::::::
NP_741 CPLHISVKEELDG
490
>>XP_011542755 (OMIM: 617007) PREDICTED: tripartite moti (343 aa)
initn: 2351 init1: 2351 opt: 2351 Z-score: 1669.0 bits: 317.8 E(85289): 3.2e-86
Smith-Waterman score: 2351; 100.0% identity (100.0% similar) in 343 aa overlap (151-493:1-343)
130 140 150 160 170 180
pF1KSD CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA
::::::::::::::::::::::::::::::
XP_011 MEHALREKAKAFWAMRRSYEAIAKHNQVEA
10 20 30
190 200 210 220 230 240
pF1KSD AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
40 50 60 70 80 90
250 260 270 280 290 300
pF1KSD LQMEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRVWKKMLASVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQMEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRVWKKMLASVE
100 110 120 130 140 150
310 320 330 340 350 360
pF1KSD SVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFSQGSHAWEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFSQGSHAWEV
160 170 180 190 200 210
370 380 390 400 410 420
pF1KSD ALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPL
220 230 240 250 260 270
430 440 450 460 470 480
pF1KSD VLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEVRPYFYLGGARGAGPPEPLRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEVRPYFYLGGARGAGPPEPLRI
280 290 300 310 320 330
490
pF1KSD CPLHISVKEELDG
:::::::::::::
XP_011 CPLHISVKEELDG
340
>>XP_005273509 (OMIM: 617007) PREDICTED: tripartite moti (298 aa)
initn: 1763 init1: 1763 opt: 1778 Z-score: 1268.2 bits: 243.4 E(85289): 6.7e-64
Smith-Waterman score: 1778; 91.0% identity (93.8% similar) in 289 aa overlap (1-281:1-289)
10 20 30 40 50 60
pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
190 200 210 220 230 240
250 260 270 280 290
pF1KSD LQMEMKEDDVSFLM---KHKSRK---RRLF-CTMEPE-PVQPGMLIDVCKYLGSLQYRVW
:::::::::::::: .: .: :. . : . : :. : . :.:
XP_005 LQMEMKEDDVSFLMTLLHHGARASPARHAYRCLQVPGLPAVPRLEEDACICGICTLQL
250 260 270 280 290
300 310 320 330 340 350
pF1KSD KKMLASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFS
>>NP_001291424 (OMIM: 617007) tripartite motif-containin (266 aa)
initn: 1073 init1: 1073 opt: 1087 Z-score: 784.6 bits: 153.8 E(85289): 5.8e-37
Smith-Waterman score: 1485; 79.9% identity (82.7% similar) in 289 aa overlap (1-281:1-257)
10 20 30 40 50 60
pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA
::::::::::::::::::::::::: :::
NP_001 CSCQADPRHQGHRVQPVKDTAHDFR--------------------------------VEA
130 140
190 200 210 220 230 240
pF1KSD AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
150 160 170 180 190 200
250 260 270 280 290
pF1KSD LQMEMKEDDVSFLM---KHKSRK---RRLF-CTMEPE-PVQPGMLIDVCKYLGSLQYRVW
:::::::::::::: .: .: :. . : . : :. : . :.:
NP_001 LQMEMKEDDVSFLMTLLHHGARASPARHAYRCLQVPGLPAVPRLEEDACICGICTLQL
210 220 230 240 250 260
300 310 320 330 340 350
pF1KSD KKMLASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFS
>>NP_742013 (OMIM: 605700) E3 ubiquitin-protein ligase T (488 aa)
initn: 570 init1: 186 opt: 670 Z-score: 489.9 bits: 100.1 E(85289): 1.5e-20
Smith-Waterman score: 670; 30.7% identity (58.8% similar) in 486 aa overlap (14-482:22-483)
10 20 30 40 50
pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWE-V
... : :.:: . ... : ..::::::..:..: :: .
NP_742 MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD QVSPTCPVCKDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLF
. . ::::. . .:: :. :...:: . .. .... . : .: :. ::::
NP_742 ERDFPCPVCRKTSRYRSLRPNRQLGSMVE--IAKQLQAVK-RKIRDESLCPQHHEALSLF
70 80 90 100 110
120 130 140 150 160 170
pF1KSD CLEDKELLCCSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEA
: ::.: .: : . :..: : :. :...... : .. . :..: . . . : :
NP_742 CYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEK
120 130 140 150 160 170
180 190 200 210 220
pF1KSD IAKHNQVEAAWLEGRIRQ---EFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLT
: .... .:.: .: ::..:.. : :.:..:. . :: .. :. .:
NP_742 --KPGELKRL-VESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLG
180 190 200 210 220 230
230 240 250 260 270 280
pF1KSD EETEVLAH---EIER--LQ--MEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVC
.. . ::: :.: :: .:: .: : : : .. : ::: :. :..
NP_742 DKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVK-----TMEVTSVS----IELE
240 250 260 270 280
290 300 310 320 330
pF1KSD KYLGSL--QYRVWKKMLASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQ--VENPE
: .... :: . .:.: .. . ..::.:: : .:.: :: :.. ..:.
NP_742 KNFSNFPRQYFALRKILKQLIA-DVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPR
290 300 310 320 330 340
340 350 360 370 380 390
pF1KSD RFSSAPCLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFW
::. ::.:... :..: : ::: .: : ::: : :: .. . .: :.:
NP_742 RFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCR---DSVSRKGELTPLPET--GYW
350 360 370 380 390
400 410 420 430 440 450
pF1KSD YVCRTQGVEGDHCVTSDPATSPLVLAI-PRRLRVELECEEGELSFYDAERHCHLYTFHAR
:.. .::. ... .:: . . :.:. . :. : : ::::.. . :.:::
NP_742 ---RVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDT
400 410 420 430 440 450
460 470 480 490
pF1KSD FGE-VRPYFYLGGARGAGPPEPLRICPLHISVKEELDG
: : . : :: : : :: : :
NP_742 FTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE
460 470 480
>>XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (555 aa)
initn: 507 init1: 219 opt: 670 Z-score: 489.3 bits: 100.2 E(85289): 1.6e-20
Smith-Waterman score: 670; 29.0% identity (58.7% similar) in 489 aa overlap (12-485:82-555)
10 20 30 40
pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFC
::..:.::::..: . ..: :.: : : ::
XP_016 GGEAAAATGSSDSAGSGLRGCAGPKRWLLSSRGLKDELLCSICLSIYQDPVSLGCEHYFC
60 70 80 90 100 110
50 60 70 80 90
pF1KSD RGCVSRCW---EVQVSPTCPVCKDR-ASPADLRTNHTLNNLVEKLLREEAEGARWTSYRF
: :... : :.: . :: :. : :: : . : :.::. . : .. :
XP_016 RRCITEHWVRQEAQGARDCPECRRTFAEPA-LAPSLKLANIVERYSSFPLD-AILNARRA
120 130 140 150 160
100 110 120 130 140 150
pF1KSD SRVCRLHRGQLSLFCLEDKELLCCSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHAL--
.: :. : ...:::: :. ::: :. :. :.: . :. ... . ... .::
XP_016 ARPCQAH-DKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQD
170 180 190 200 210 220
160 170 180 190 200 210
pF1KSD --REKAKAFWAMRRSYEAIAKHNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEET
::...:. ..:. . .. :. : . :..:...:: ...:.:. . .:
XP_016 SEREHTEALQLLKRQLAETKSSTKS----LRTTIGEAFERLHRLLRERQKAMLEELEADT
230 240 250 260 270 280
220 230 240 250 260 270
pF1KSD RQKQLLADEKMKQLTEETEVLAHEIERLQMEMKEDDV-SFLMKHKSRKRRLFCTMEPEPV
. ..:... ... . . . . :: .. : : .:: : ..:: .. :
XP_016 ARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIH-ETN
290 300 310 320 330 340
280 290 300 310 320 330
pF1KSD QPGMLIDVCKYLGSLQYRVWKKMLASVESVP--FSFDPNTAAGWLSVSDDLTSVTNHGYR
. . :: : ::: .::... ... :: ...::.:: : .::: : :. . .
XP_016 LTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLH
350 360 370 380 390 400
340 350 360 370 380
pF1KSD VQV--ENPERFSSAPCLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSC
: ..:.::. .:::..::.: : :::... .: .:... : ... :
XP_016 PQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHE-----AASRKGSI
410 420 430 440 450
390 400 410 420 430 440
pF1KSD YHDTRSGFWYVCRTQGVEGDHCVTSDPATSPLVLAIPRRLRVELECEEGELSFYDAERHC
. ::. . .: . . : ..: : : .. : :. ..: : ::.:.
XP_016 QIQPSRGFYCIVMHDGNQYSAC--TEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMS
460 470 480 490 500 510
450 460 470 480 490
pF1KSD HLYTFHARF-GEVRPYFYLGGARGAGPP-EPLRICPLHISVKEELDG
::::. .: :.. :: : ... : .:::: ..:
XP_016 WLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI
520 530 540 550
>>NP_060677 (OMIM: 616755) E3 ubiquitin-protein ligase T (475 aa)
initn: 486 init1: 219 opt: 663 Z-score: 485.1 bits: 99.2 E(85289): 2.8e-20
Smith-Waterman score: 663; 29.0% identity (58.5% similar) in 487 aa overlap (14-485:4-475)
10 20 30 40 50
pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCW---EVQVSPTC
:.:.::::..: . ..: :.: : : ::: :... : :.: . :
NP_060 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDC
10 20 30 40 50
60 70 80 90 100 110
pF1KSD PVCKDR-ASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDK
: :. : :: : . : :.::. . : .. : .: :. : ...:::: :.
NP_060 PECRRTFAEPA-LAPSLKLANIVERYSSFPLD-AILNARRAARPCQAH-DKVKLFCLTDR
60 70 80 90 100
120 130 140 150 160 170
pF1KSD ELLCCSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHAL----REKAKAFWAMRRSYEAI
::: :. :. :.: . :. ... . ... .:: ::...:. ..:.
NP_060 ALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAET
110 120 130 140 150 160
180 190 200 210 220 230
pF1KSD AKHNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETE
. .. :. : . :..:...:: ...:.:. . .: . ..:... ... .
NP_060 KSSTKS----LRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLR
170 180 190 200 210 220
240 250 260 270 280 290
pF1KSD VLAHEIERLQMEMKEDDV-SFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRV
. . . :: .. : : .:: : ..:: .. : . . :: : ::: .
NP_060 KVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIH-ETNLTYEDFPTSKYTGPLQYTI
230 240 250 260 270 280
300 310 320 330 340
pF1KSD WKKMLASVESVP--FSFDPNTAAGWLSVSDDLTSVTNHGYRVQV--ENPERFSSAPCLLG
::... ... :: ...::.:: : .::: : :. . . : ..:.::. .::
NP_060 WKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLG
290 300 310 320 330 340
350 360 370 380 390 400
pF1KSD SRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEG
:..::.: : :::... .: .:... : ... : . ::. . .: .
NP_060 SEAFSSGVHYWEVVVAEKTQWVIGLAHE-----AASRKGSIQIQPSRGFYCIVMHDGNQY
350 360 370 380 390
410 420 430 440 450 460
pF1KSD DHCVTSDPATSPLVLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARF-GEVRPYFYL
. : ..: : : .. : :. ..: : ::.:. ::::. .: :.. ::
NP_060 SAC--TEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSP
400 410 420 430 440 450
470 480 490
pF1KSD GGARGAGPP-EPLRICPLHISVKEELDG
: ... : .:::: ..:
NP_060 GQSHANGKNVQPLRINTVRI
460 470
>>NP_892030 (OMIM: 616017) E3 ubiquitin-protein ligase T (500 aa)
initn: 541 init1: 161 opt: 643 Z-score: 470.9 bits: 96.6 E(85289): 1.7e-19
Smith-Waterman score: 643; 29.3% identity (56.2% similar) in 505 aa overlap (1-484:17-498)
10 20 30 40
pF1KSD MERSPDVSPGPSR----SFKEELLCAVCYDPFRDAVTLRCGHNF
.: . ... ::. .. :: : .: : ::: . : :::::
NP_892 MEVSTNPSSNIDPGDYVEMNDSITHLPSKVVIQDITMELHCPLCNDWFRDPLMLSCGHNF
10 20 30 40 50 60
50 60 70 80 90
pF1KSD CRGCVSRCWEVQVSPT-CPVCKDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSR
:..:.. :..:.. : :: :: . . : .:..::::. . .
NP_892 CEACIQDFWRLQAKETFCPECKMLCQYNNCTFNPVLDKLVEKI-------KKLPLLKGHP
70 80 90 100 110
100 110 120 130 140 150
pF1KSD VCRLHRGQLSLFCLEDKELLCCSCQADPR---HQGHRVQPVKDTAHDFRAKCRNMEHALR
: : .:.:: : .:.: .:. : : :... ..:..: : . .. :.
NP_892 QCPEHGENLKLFSKPDGKLICFQCK-DARLSVGQSKEFLQISDAVHFFTEELAIQQGQLE
120 130 140 150 160 170
160 170 180 190 200 210
pF1KSD EKAKAFWAMRR-SYEAIAKHNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQ
: . ..: . :::: :.. . :. .. .:: ::..::. .:. :: . :: .
NP_892 TTLKELQTLRNMQKEAIAAHKENKLH-LQQHVSMEFLKLHQFLHSKEKDILTELREEGKA
180 190 200 210 220 230
220 230 240 250 260
pF1KSD KQLLADEKMKQLTEETEVLAHEIERLQMEMKED-------DVSFLMKHKSRKRRLFCTME
. . ...:: :. . . .: . ... :.. :.. . ... : :
NP_892 LNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVLATRE
240 250 260 270 280 290
270 280 290 300 310 320
pF1KSD PEPVQPGMLIDVCKYLGSLQYRVWKKMLASVES--VPFSFDPNTAAGWLSVSDDLTSVTN
. ... .: : .:: ::..: .. :...::.:: : .: . :::
NP_892 ----LISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVW-
300 310 320 330 340
330 340 350 360 370 380
pF1KSD HG--YRVQVENPERFSSAPCLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGH
:: ... ..::::.:. .:::: :..:. ::: .. .: ::::: .. .:
NP_892 HGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVR--ESIIRKG-
350 360 370 380 390 400
390 400 410 420 430 440
pF1KSD SHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPLVLAIPRRLRVELECEEGELSFYDA
:: ..::: . : .. . : . . :. : . .. . :. : :.::::.:
NP_892 --SCPLTPEQGFWLL-RLRN-QTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNA
410 420 430 440 450
450 460 470 480 490
pF1KSD ERHCHLYTFHARFGE-VRPYFYLGGARGAGPPEPLRICPLHISVKEELDG
. :.::: : : . ::: :. :::.: ::
NP_892 KTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHI--LHPQ
460 470 480 490 500
>>NP_660215 (OMIM: 607868) E3 ubiquitin-protein ligase T (468 aa)
initn: 593 init1: 223 opt: 642 Z-score: 470.4 bits: 96.4 E(85289): 1.8e-19
Smith-Waterman score: 740; 31.2% identity (57.4% similar) in 481 aa overlap (8-481:3-455)
10 20 30 40 50
pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSP-TCPV
.: : ...:: ::.: : : : : ::::::: :. ::: .: .::
NP_660 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPE
10 20 30 40 50
60 70 80 90 100 110
pF1KSD CKDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELL
:.. . .:: :. : ...: : . : . :: :: :. :: .. .::
NP_660 CRELSPQRNLRPNRPLAKMAEMARRLHPP-----SPVPQGVCPAHREPLAAFCGDELRLL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KSD CCSCQADPRHQGHRVQPVKDTAHDFRAKC-RNMEHALREKAKAFWAMRRSYEA-IAKHNQ
: .:. . .: .:::.:..:.:.:..:: ...:: .. :. . .. :. . ...
NP_660 CAACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKM
120 130 140 150 160 170
180 190 200 210 220 230
pF1KSD VEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHE
::. . . ::..::..: ::: .:. . :: . : .: ... ::.
NP_660 VESQ--RQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAEL
180 190 200 210 220
240 250 260 270 280 290
pF1KSD IERLQMEMKEDDVSFLMKHKSRKRRLF-CTMEPEPVQPGMLIDVCKYLGSLQYRVWKKML
: .:. . . ...:. :. ::. ..: : : : ::. : .. . ...
NP_660 IAELEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVE--TLRRFR
230 240 250 260 270 280
300 310 320 330 340 350
pF1KSD ASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQV-ENPERFSSAPCLLGSRVFSQGS
..: ..::.:: : .:.: :: : . ..::::. .::.::.. :..:
NP_660 GDV-----TLDPDTANPELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGR
290 300 310 320 330 340
360 370 380 390 400 410
pF1KSD HAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDP
: ::: .: :: .:: : . .:. .. .::: . :.. .:.
NP_660 HYWEVEVGDRTSWALGVCRENVNRKEKGEL-----SAGNGFWILVFL----GSYYNSSER
350 360 370 380 390
420 430 440 450 460 470
pF1KSD ATSPLVLAIPRRLRVELECEEGELSFYDAERHCHLYTF-HARF-GEVRPYFYLGGARGAG
: .:: :::. . :. : :.::::.: :. : . : : .:: : . ..
NP_660 ALAPLR-DPPRRVGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLF----SPLSS
400 410 420 430 440
480 490
pF1KSD PPEPLRICPLHISVKEELDG
: :. ::
NP_660 SPTPMTICRPKGGSGDTLAPQ
450 460
>>NP_001268380 (OMIM: 612548) E3 ubiquitin-protein ligas (487 aa)
initn: 497 init1: 172 opt: 596 Z-score: 438.0 bits: 90.5 E(85289): 1.2e-17
Smith-Waterman score: 596; 28.6% identity (57.4% similar) in 472 aa overlap (15-462:10-452)
10 20 30 40 50
pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGC-VSRCWEVQVSPTCPV
....: : .: . :.. . :.:::..:.:: :: .... :::
NP_001 MAWQVSLPELEDRLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPV
10 20 30 40 50
60 70 80 90 100 110
pF1KSD CKDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELL
:.. .. .. : .: ..: : : . .:: ::. ::::: .:.::.
NP_001 CRQAVDGSSSLPNVSLARVIEAL--------RLPGDPEPKVCVHHRNPLSLFCEKDQELI
60 70 80 90 100
120 130 140 150 160 170
pF1KSD CCSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKA----FWAMRRSYEAIAKH
: : :: : : ::. . .. . . :... : . . . :...
NP_001 CGLCGLLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNE
110 120 130 140 150 160
180 190 200 210 220 230
pF1KSD NQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLA
..: . :. ::.::..:.... :. :.... .:: : ...: : ::
NP_001 SDVFS-WV---IRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLA
170 180 190 200 210 220
240 250 260 270 280
pF1KSD HEIERLQMEMKEDDVSFLMKHKS--------RKRRLFCTMEPEPVQPGMLIDVCKYLGSL
. :.. .:: .:. : .: . : : .. : .::. . ...
NP_001 QAECVLEQFGNEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGL------HQADI
230 240 250 260 270
290 300 310 320 330 340
pF1KSD QYRVWKKMLASVESVP--FSFDPNTAAGWLSVSDDLTSVTNHGYRVQ--VENPERFSSAP
. :::... .: .: ...:: :: : .: ..:.. : .: . .::::. .
NP_001 KLTVWKRLFRKVLPAPEPLKLDPATAHPLLELSKG-NTVVQCGLLAQRRASQPERFDYST
280 290 300 310 320 330
350 360 370 380 390 400
pF1KSD CLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQ
:.:.:: :: : : :::..:. ..::.::.. :. ... . .. . : : . .
NP_001 CVLASRGFSCGRHYWEVVVGSKSDWRLGVIK-----GTASRKGKLNRSPEHGVWLIGLKE
340 350 360 370 380 390
410 420 430 440 450
pF1KSD G--VEGDHCVTSDPATSPLVLAI-PRRLRVELECEEGELSFYDAERHCHL---YTFHARF
: :. : : . :: .: :.:. . :. :.:::.:.::.: : :::.: :
NP_001 GRVYEAFAC----PRV-PLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADF
400 410 420 430 440
460 470 480 490
pF1KSD -GEVRPYFYLGGARGAGPPEPLRICPLHISVKEELDG
:.. :
NP_001 QGKLYPILDTCWHERGSNSLPMVLPPPSGPGPLSPEQPTKL
450 460 470 480
493 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 19:01:22 2016 done: Thu Nov 3 19:01:24 2016
Total Scan time: 10.140 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]