FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1098, 493 aa 1>>>pF1KSDA1098 493 - 493 aa - 493 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1842+/-0.000428; mu= 15.7987+/- 0.026 mean_var=203.7612+/-44.692, 0's: 0 Z-trim(117.2): 235 B-trim: 1395 in 1/57 Lambda= 0.089849 statistics sampled from 28755 (29076) to 28755 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.341), width: 16 Scan time: 10.140 The best scores are: opt bits E(85289) NP_741983 (OMIM: 617007) tripartite motif-containi ( 493) 3451 460.6 4.6e-129 XP_011542755 (OMIM: 617007) PREDICTED: tripartite ( 343) 2351 317.8 3.2e-86 XP_005273509 (OMIM: 617007) PREDICTED: tripartite ( 298) 1778 243.4 6.7e-64 NP_001291424 (OMIM: 617007) tripartite motif-conta ( 266) 1087 153.8 5.8e-37 NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 670 100.1 1.5e-20 XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 555) 670 100.2 1.6e-20 NP_060677 (OMIM: 616755) E3 ubiquitin-protein liga ( 475) 663 99.2 2.8e-20 NP_892030 (OMIM: 616017) E3 ubiquitin-protein liga ( 500) 643 96.6 1.7e-19 NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 642 96.4 1.8e-19 NP_001268380 (OMIM: 612548) E3 ubiquitin-protein l ( 487) 596 90.5 1.2e-17 NP_835226 (OMIM: 612548) E3 ubiquitin-protein liga ( 487) 596 90.5 1.2e-17 XP_011514091 (OMIM: 612548) PREDICTED: E3 ubiquiti ( 486) 595 90.4 1.3e-17 NP_001268379 (OMIM: 612548) E3 ubiquitin-protein l ( 486) 595 90.4 1.3e-17 XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 572 87.4 9.9e-17 XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 572 87.4 9.9e-17 NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 572 87.4 9.9e-17 NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 572 87.4 9.9e-17 XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 572 87.4 9.9e-17 NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 568 86.9 1.4e-16 NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475) 557 85.4 3.8e-16 XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 512 79.6 2.1e-14 XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 478 75.2 4.6e-13 NP_001008275 (OMIM: 613288) tripartite motif-conta ( 477) 464 73.4 1.6e-12 NP_006769 (OMIM: 605701) tripartite motif-containi ( 481) 448 71.3 6.9e-12 NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 438 70.0 1.7e-11 NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 438 70.1 1.8e-11 NP_291027 (OMIM: 610530) E3 ubiquitin-protein liga ( 630) 432 69.4 3.4e-11 NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 416 67.2 1.2e-10 NP_001186502 (OMIM: 606559) E3 ubiquitin-protein l ( 494) 413 66.8 1.6e-10 XP_011512524 (OMIM: 605701) PREDICTED: tripartite ( 499) 412 66.7 1.8e-10 XP_011512525 (OMIM: 605701) PREDICTED: tripartite ( 499) 412 66.7 1.8e-10 XP_011512523 (OMIM: 605701) PREDICTED: tripartite ( 499) 412 66.7 1.8e-10 NP_542783 (OMIM: 616017) E3 ubiquitin-protein liga ( 341) 404 65.4 3e-10 NP_439893 (OMIM: 605701) tripartite motif-containi ( 395) 398 64.7 5.5e-10 NP_001317412 (OMIM: 616755) E3 ubiquitin-protein l ( 354) 394 64.1 7.4e-10 XP_006714995 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 520) 393 64.2 1e-09 XP_006714992 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 543) 393 64.3 1e-09 NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 392 64.1 1.1e-09 XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391) 386 63.1 1.6e-09 NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 385 62.9 1.6e-09 NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488) 384 63.0 2.2e-09 NP_067629 (OMIM: 605684) tripartite motif-containi ( 488) 384 63.0 2.2e-09 NP_001288073 (OMIM: 616017) E3 ubiquitin-protein l ( 296) 379 62.1 2.6e-09 NP_963921 (OMIM: 610530) E3 ubiquitin-protein liga ( 518) 380 62.5 3.2e-09 XP_006714993 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 541) 380 62.6 3.3e-09 XP_006714994 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 525) 375 61.9 5.1e-09 XP_016857119 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 544) 373 61.7 6.2e-09 XP_005249433 (OMIM: 600830) PREDICTED: tripartite ( 539) 364 60.5 1.4e-08 XP_005249434 (OMIM: 600830) PREDICTED: tripartite ( 539) 364 60.5 1.4e-08 NP_001229712 (OMIM: 600830) tripartite motif-conta ( 539) 364 60.5 1.4e-08 >>NP_741983 (OMIM: 617007) tripartite motif-containing p (493 aa) initn: 3451 init1: 3451 opt: 3451 Z-score: 2438.1 bits: 460.6 E(85289): 4.6e-129 Smith-Waterman score: 3451; 100.0% identity (100.0% similar) in 493 aa overlap (1-493:1-493) 10 20 30 40 50 60 pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LQMEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRVWKKMLASVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 LQMEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRVWKKMLASVE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFSQGSHAWEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 SVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFSQGSHAWEV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD ALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 ALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEVRPYFYLGGARGAGPPEPLRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_741 VLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEVRPYFYLGGARGAGPPEPLRI 430 440 450 460 470 480 490 pF1KSD CPLHISVKEELDG ::::::::::::: NP_741 CPLHISVKEELDG 490 >>XP_011542755 (OMIM: 617007) PREDICTED: tripartite moti (343 aa) initn: 2351 init1: 2351 opt: 2351 Z-score: 1669.0 bits: 317.8 E(85289): 3.2e-86 Smith-Waterman score: 2351; 100.0% identity (100.0% similar) in 343 aa overlap (151-493:1-343) 130 140 150 160 170 180 pF1KSD CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA :::::::::::::::::::::::::::::: XP_011 MEHALREKAKAFWAMRRSYEAIAKHNQVEA 10 20 30 190 200 210 220 230 240 pF1KSD AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER 40 50 60 70 80 90 250 260 270 280 290 300 pF1KSD LQMEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRVWKKMLASVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQMEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRVWKKMLASVE 100 110 120 130 140 150 310 320 330 340 350 360 pF1KSD SVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFSQGSHAWEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFSQGSHAWEV 160 170 180 190 200 210 370 380 390 400 410 420 pF1KSD ALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPL 220 230 240 250 260 270 430 440 450 460 470 480 pF1KSD VLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEVRPYFYLGGARGAGPPEPLRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEVRPYFYLGGARGAGPPEPLRI 280 290 300 310 320 330 490 pF1KSD CPLHISVKEELDG ::::::::::::: XP_011 CPLHISVKEELDG 340 >>XP_005273509 (OMIM: 617007) PREDICTED: tripartite moti (298 aa) initn: 1763 init1: 1763 opt: 1778 Z-score: 1268.2 bits: 243.4 E(85289): 6.7e-64 Smith-Waterman score: 1778; 91.0% identity (93.8% similar) in 289 aa overlap (1-281:1-289) 10 20 30 40 50 60 pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER 190 200 210 220 230 240 250 260 270 280 290 pF1KSD LQMEMKEDDVSFLM---KHKSRK---RRLF-CTMEPE-PVQPGMLIDVCKYLGSLQYRVW :::::::::::::: .: .: :. . : . : :. : . :.: XP_005 LQMEMKEDDVSFLMTLLHHGARASPARHAYRCLQVPGLPAVPRLEEDACICGICTLQL 250 260 270 280 290 300 310 320 330 340 350 pF1KSD KKMLASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFS >>NP_001291424 (OMIM: 617007) tripartite motif-containin (266 aa) initn: 1073 init1: 1073 opt: 1087 Z-score: 784.6 bits: 153.8 E(85289): 5.8e-37 Smith-Waterman score: 1485; 79.9% identity (82.7% similar) in 289 aa overlap (1-281:1-257) 10 20 30 40 50 60 pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA ::::::::::::::::::::::::: ::: NP_001 CSCQADPRHQGHRVQPVKDTAHDFR--------------------------------VEA 130 140 190 200 210 220 230 240 pF1KSD AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER 150 160 170 180 190 200 250 260 270 280 290 pF1KSD LQMEMKEDDVSFLM---KHKSRK---RRLF-CTMEPE-PVQPGMLIDVCKYLGSLQYRVW :::::::::::::: .: .: :. . : . : :. : . :.: NP_001 LQMEMKEDDVSFLMTLLHHGARASPARHAYRCLQVPGLPAVPRLEEDACICGICTLQL 210 220 230 240 250 260 300 310 320 330 340 350 pF1KSD KKMLASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFS >>NP_742013 (OMIM: 605700) E3 ubiquitin-protein ligase T (488 aa) initn: 570 init1: 186 opt: 670 Z-score: 489.9 bits: 100.1 E(85289): 1.5e-20 Smith-Waterman score: 670; 30.7% identity (58.8% similar) in 486 aa overlap (14-482:22-483) 10 20 30 40 50 pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWE-V ... : :.:: . ... : ..::::::..:..: :: . NP_742 MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KSD QVSPTCPVCKDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLF . . ::::. . .:: :. :...:: . .. .... . : .: :. :::: NP_742 ERDFPCPVCRKTSRYRSLRPNRQLGSMVE--IAKQLQAVK-RKIRDESLCPQHHEALSLF 70 80 90 100 110 120 130 140 150 160 170 pF1KSD CLEDKELLCCSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEA : ::.: .: : . :..: : :. :...... : .. . :..: . . . : : NP_742 CYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEK 120 130 140 150 160 170 180 190 200 210 220 pF1KSD IAKHNQVEAAWLEGRIRQ---EFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLT : .... .:.: .: ::..:.. : :.:..:. . :: .. :. .: NP_742 --KPGELKRL-VESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLG 180 190 200 210 220 230 230 240 250 260 270 280 pF1KSD EETEVLAH---EIER--LQ--MEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVC .. . ::: :.: :: .:: .: : : : .. : ::: :. :.. NP_742 DKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVK-----TMEVTSVS----IELE 240 250 260 270 280 290 300 310 320 330 pF1KSD KYLGSL--QYRVWKKMLASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQ--VENPE : .... :: . .:.: .. . ..::.:: : .:.: :: :.. ..:. NP_742 KNFSNFPRQYFALRKILKQLIA-DVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPR 290 300 310 320 330 340 340 350 360 370 380 390 pF1KSD RFSSAPCLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFW ::. ::.:... :..: : ::: .: : ::: : :: .. . .: :.: NP_742 RFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCR---DSVSRKGELTPLPET--GYW 350 360 370 380 390 400 410 420 430 440 450 pF1KSD YVCRTQGVEGDHCVTSDPATSPLVLAI-PRRLRVELECEEGELSFYDAERHCHLYTFHAR :.. .::. ... .:: . . :.:. . :. : : ::::.. . :.::: NP_742 ---RVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDT 400 410 420 430 440 450 460 470 480 490 pF1KSD FGE-VRPYFYLGGARGAGPPEPLRICPLHISVKEELDG : : . : :: : : :: : : NP_742 FTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE 460 470 480 >>XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (555 aa) initn: 507 init1: 219 opt: 670 Z-score: 489.3 bits: 100.2 E(85289): 1.6e-20 Smith-Waterman score: 670; 29.0% identity (58.7% similar) in 489 aa overlap (12-485:82-555) 10 20 30 40 pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFC ::..:.::::..: . ..: :.: : : :: XP_016 GGEAAAATGSSDSAGSGLRGCAGPKRWLLSSRGLKDELLCSICLSIYQDPVSLGCEHYFC 60 70 80 90 100 110 50 60 70 80 90 pF1KSD RGCVSRCW---EVQVSPTCPVCKDR-ASPADLRTNHTLNNLVEKLLREEAEGARWTSYRF : :... : :.: . :: :. : :: : . : :.::. . : .. : XP_016 RRCITEHWVRQEAQGARDCPECRRTFAEPA-LAPSLKLANIVERYSSFPLD-AILNARRA 120 130 140 150 160 100 110 120 130 140 150 pF1KSD SRVCRLHRGQLSLFCLEDKELLCCSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHAL-- .: :. : ...:::: :. ::: :. :. :.: . :. ... . ... .:: XP_016 ARPCQAH-DKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQD 170 180 190 200 210 220 160 170 180 190 200 210 pF1KSD --REKAKAFWAMRRSYEAIAKHNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEET ::...:. ..:. . .. :. : . :..:...:: ...:.:. . .: XP_016 SEREHTEALQLLKRQLAETKSSTKS----LRTTIGEAFERLHRLLRERQKAMLEELEADT 230 240 250 260 270 280 220 230 240 250 260 270 pF1KSD RQKQLLADEKMKQLTEETEVLAHEIERLQMEMKEDDV-SFLMKHKSRKRRLFCTMEPEPV . ..:... ... . . . . :: .. : : .:: : ..:: .. : XP_016 ARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIH-ETN 290 300 310 320 330 340 280 290 300 310 320 330 pF1KSD QPGMLIDVCKYLGSLQYRVWKKMLASVESVP--FSFDPNTAAGWLSVSDDLTSVTNHGYR . . :: : ::: .::... ... :: ...::.:: : .::: : :. . . XP_016 LTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLH 350 360 370 380 390 400 340 350 360 370 380 pF1KSD VQV--ENPERFSSAPCLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSC : ..:.::. .:::..::.: : :::... .: .:... : ... : XP_016 PQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHE-----AASRKGSI 410 420 430 440 450 390 400 410 420 430 440 pF1KSD YHDTRSGFWYVCRTQGVEGDHCVTSDPATSPLVLAIPRRLRVELECEEGELSFYDAERHC . ::. . .: . . : ..: : : .. : :. ..: : ::.:. XP_016 QIQPSRGFYCIVMHDGNQYSAC--TEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMS 460 470 480 490 500 510 450 460 470 480 490 pF1KSD HLYTFHARF-GEVRPYFYLGGARGAGPP-EPLRICPLHISVKEELDG ::::. .: :.. :: : ... : .:::: ..: XP_016 WLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI 520 530 540 550 >>NP_060677 (OMIM: 616755) E3 ubiquitin-protein ligase T (475 aa) initn: 486 init1: 219 opt: 663 Z-score: 485.1 bits: 99.2 E(85289): 2.8e-20 Smith-Waterman score: 663; 29.0% identity (58.5% similar) in 487 aa overlap (14-485:4-475) 10 20 30 40 50 pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCW---EVQVSPTC :.:.::::..: . ..: :.: : : ::: :... : :.: . : NP_060 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDC 10 20 30 40 50 60 70 80 90 100 110 pF1KSD PVCKDR-ASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDK : :. : :: : . : :.::. . : .. : .: :. : ...:::: :. NP_060 PECRRTFAEPA-LAPSLKLANIVERYSSFPLD-AILNARRAARPCQAH-DKVKLFCLTDR 60 70 80 90 100 120 130 140 150 160 170 pF1KSD ELLCCSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHAL----REKAKAFWAMRRSYEAI ::: :. :. :.: . :. ... . ... .:: ::...:. ..:. NP_060 ALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAET 110 120 130 140 150 160 180 190 200 210 220 230 pF1KSD AKHNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETE . .. :. : . :..:...:: ...:.:. . .: . ..:... ... . NP_060 KSSTKS----LRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLR 170 180 190 200 210 220 240 250 260 270 280 290 pF1KSD VLAHEIERLQMEMKEDDV-SFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRV . . . :: .. : : .:: : ..:: .. : . . :: : ::: . NP_060 KVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIH-ETNLTYEDFPTSKYTGPLQYTI 230 240 250 260 270 280 300 310 320 330 340 pF1KSD WKKMLASVESVP--FSFDPNTAAGWLSVSDDLTSVTNHGYRVQV--ENPERFSSAPCLLG ::... ... :: ...::.:: : .::: : :. . . : ..:.::. .:: NP_060 WKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLG 290 300 310 320 330 340 350 360 370 380 390 400 pF1KSD SRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEG :..::.: : :::... .: .:... : ... : . ::. . .: . NP_060 SEAFSSGVHYWEVVVAEKTQWVIGLAHE-----AASRKGSIQIQPSRGFYCIVMHDGNQY 350 360 370 380 390 410 420 430 440 450 460 pF1KSD DHCVTSDPATSPLVLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARF-GEVRPYFYL . : ..: : : .. : :. ..: : ::.:. ::::. .: :.. :: NP_060 SAC--TEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSP 400 410 420 430 440 450 470 480 490 pF1KSD GGARGAGPP-EPLRICPLHISVKEELDG : ... : .:::: ..: NP_060 GQSHANGKNVQPLRINTVRI 460 470 >>NP_892030 (OMIM: 616017) E3 ubiquitin-protein ligase T (500 aa) initn: 541 init1: 161 opt: 643 Z-score: 470.9 bits: 96.6 E(85289): 1.7e-19 Smith-Waterman score: 643; 29.3% identity (56.2% similar) in 505 aa overlap (1-484:17-498) 10 20 30 40 pF1KSD MERSPDVSPGPSR----SFKEELLCAVCYDPFRDAVTLRCGHNF .: . ... ::. .. :: : .: : ::: . : ::::: NP_892 MEVSTNPSSNIDPGDYVEMNDSITHLPSKVVIQDITMELHCPLCNDWFRDPLMLSCGHNF 10 20 30 40 50 60 50 60 70 80 90 pF1KSD CRGCVSRCWEVQVSPT-CPVCKDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSR :..:.. :..:.. : :: :: . . : .:..::::. . . NP_892 CEACIQDFWRLQAKETFCPECKMLCQYNNCTFNPVLDKLVEKI-------KKLPLLKGHP 70 80 90 100 110 100 110 120 130 140 150 pF1KSD VCRLHRGQLSLFCLEDKELLCCSCQADPR---HQGHRVQPVKDTAHDFRAKCRNMEHALR : : .:.:: : .:.: .:. : : :... ..:..: : . .. :. NP_892 QCPEHGENLKLFSKPDGKLICFQCK-DARLSVGQSKEFLQISDAVHFFTEELAIQQGQLE 120 130 140 150 160 170 160 170 180 190 200 210 pF1KSD EKAKAFWAMRR-SYEAIAKHNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQ : . ..: . :::: :.. . :. .. .:: ::..::. .:. :: . :: . NP_892 TTLKELQTLRNMQKEAIAAHKENKLH-LQQHVSMEFLKLHQFLHSKEKDILTELREEGKA 180 190 200 210 220 230 220 230 240 250 260 pF1KSD KQLLADEKMKQLTEETEVLAHEIERLQMEMKED-------DVSFLMKHKSRKRRLFCTME . . ...:: :. . . .: . ... :.. :.. . ... : : NP_892 LNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVLATRE 240 250 260 270 280 290 270 280 290 300 310 320 pF1KSD PEPVQPGMLIDVCKYLGSLQYRVWKKMLASVES--VPFSFDPNTAAGWLSVSDDLTSVTN . ... .: : .:: ::..: .. :...::.:: : .: . ::: NP_892 ----LISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVW- 300 310 320 330 340 330 340 350 360 370 380 pF1KSD HG--YRVQVENPERFSSAPCLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGH :: ... ..::::.:. .:::: :..:. ::: .. .: ::::: .. .: NP_892 HGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVR--ESIIRKG- 350 360 370 380 390 400 390 400 410 420 430 440 pF1KSD SHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPLVLAIPRRLRVELECEEGELSFYDA :: ..::: . : .. . : . . :. : . .. . :. : :.::::.: NP_892 --SCPLTPEQGFWLL-RLRN-QTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNA 410 420 430 440 450 450 460 470 480 490 pF1KSD ERHCHLYTFHARFGE-VRPYFYLGGARGAGPPEPLRICPLHISVKEELDG . :.::: : : . ::: :. :::.: :: NP_892 KTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHI--LHPQ 460 470 480 490 500 >>NP_660215 (OMIM: 607868) E3 ubiquitin-protein ligase T (468 aa) initn: 593 init1: 223 opt: 642 Z-score: 470.4 bits: 96.4 E(85289): 1.8e-19 Smith-Waterman score: 740; 31.2% identity (57.4% similar) in 481 aa overlap (8-481:3-455) 10 20 30 40 50 pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSP-TCPV .: : ...:: ::.: : : : : ::::::: :. ::: .: .:: NP_660 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPE 10 20 30 40 50 60 70 80 90 100 110 pF1KSD CKDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELL :.. . .:: :. : ...: : . : . :: :: :. :: .. .:: NP_660 CRELSPQRNLRPNRPLAKMAEMARRLHPP-----SPVPQGVCPAHREPLAAFCGDELRLL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KSD CCSCQADPRHQGHRVQPVKDTAHDFRAKC-RNMEHALREKAKAFWAMRRSYEA-IAKHNQ : .:. . .: .:::.:..:.:.:..:: ...:: .. :. . .. :. . ... NP_660 CAACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKM 120 130 140 150 160 170 180 190 200 210 220 230 pF1KSD VEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHE ::. . . ::..::..: ::: .:. . :: . : .: ... ::. NP_660 VESQ--RQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAEL 180 190 200 210 220 240 250 260 270 280 290 pF1KSD IERLQMEMKEDDVSFLMKHKSRKRRLF-CTMEPEPVQPGMLIDVCKYLGSLQYRVWKKML : .:. . . ...:. :. ::. ..: : : : ::. : .. . ... NP_660 IAELEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVE--TLRRFR 230 240 250 260 270 280 300 310 320 330 340 350 pF1KSD ASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQV-ENPERFSSAPCLLGSRVFSQGS ..: ..::.:: : .:.: :: : . ..::::. .::.::.. :..: NP_660 GDV-----TLDPDTANPELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGR 290 300 310 320 330 340 360 370 380 390 400 410 pF1KSD HAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDP : ::: .: :: .:: : . .:. .. .::: . :.. .:. NP_660 HYWEVEVGDRTSWALGVCRENVNRKEKGEL-----SAGNGFWILVFL----GSYYNSSER 350 360 370 380 390 420 430 440 450 460 470 pF1KSD ATSPLVLAIPRRLRVELECEEGELSFYDAERHCHLYTF-HARF-GEVRPYFYLGGARGAG : .:: :::. . :. : :.::::.: :. : . : : .:: : . .. NP_660 ALAPLR-DPPRRVGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLF----SPLSS 400 410 420 430 440 480 490 pF1KSD PPEPLRICPLHISVKEELDG : :. :: NP_660 SPTPMTICRPKGGSGDTLAPQ 450 460 >>NP_001268380 (OMIM: 612548) E3 ubiquitin-protein ligas (487 aa) initn: 497 init1: 172 opt: 596 Z-score: 438.0 bits: 90.5 E(85289): 1.2e-17 Smith-Waterman score: 596; 28.6% identity (57.4% similar) in 472 aa overlap (15-462:10-452) 10 20 30 40 50 pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGC-VSRCWEVQVSPTCPV ....: : .: . :.. . :.:::..:.:: :: .... ::: NP_001 MAWQVSLPELEDRLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPV 10 20 30 40 50 60 70 80 90 100 110 pF1KSD CKDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELL :.. .. .. : .: ..: : : . .:: ::. ::::: .:.::. NP_001 CRQAVDGSSSLPNVSLARVIEAL--------RLPGDPEPKVCVHHRNPLSLFCEKDQELI 60 70 80 90 100 120 130 140 150 160 170 pF1KSD CCSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKA----FWAMRRSYEAIAKH : : :: : : ::. . .. . . :... : . . . :... NP_001 CGLCGLLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNE 110 120 130 140 150 160 180 190 200 210 220 230 pF1KSD NQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLA ..: . :. ::.::..:.... :. :.... .:: : ...: : :: NP_001 SDVFS-WV---IRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLA 170 180 190 200 210 220 240 250 260 270 280 pF1KSD HEIERLQMEMKEDDVSFLMKHKS--------RKRRLFCTMEPEPVQPGMLIDVCKYLGSL . :.. .:: .:. : .: . : : .. : .::. . ... NP_001 QAECVLEQFGNEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGL------HQADI 230 240 250 260 270 290 300 310 320 330 340 pF1KSD QYRVWKKMLASVESVP--FSFDPNTAAGWLSVSDDLTSVTNHGYRVQ--VENPERFSSAP . :::... .: .: ...:: :: : .: ..:.. : .: . .::::. . NP_001 KLTVWKRLFRKVLPAPEPLKLDPATAHPLLELSKG-NTVVQCGLLAQRRASQPERFDYST 280 290 300 310 320 330 350 360 370 380 390 400 pF1KSD CLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQ :.:.:: :: : : :::..:. ..::.::.. :. ... . .. . : : . . NP_001 CVLASRGFSCGRHYWEVVVGSKSDWRLGVIK-----GTASRKGKLNRSPEHGVWLIGLKE 340 350 360 370 380 390 410 420 430 440 450 pF1KSD G--VEGDHCVTSDPATSPLVLAI-PRRLRVELECEEGELSFYDAERHCHL---YTFHARF : :. : : . :: .: :.:. . :. :.:::.:.::.: : :::.: : NP_001 GRVYEAFAC----PRV-PLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADF 400 410 420 430 440 460 470 480 490 pF1KSD -GEVRPYFYLGGARGAGPPEPLRICPLHISVKEELDG :.. : NP_001 QGKLYPILDTCWHERGSNSLPMVLPPPSGPGPLSPEQPTKL 450 460 470 480 493 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 19:01:22 2016 done: Thu Nov 3 19:01:24 2016 Total Scan time: 10.140 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]