Result of FASTA (omim) for pF1KSDA1098
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA1098, 493 aa
  1>>>pF1KSDA1098 493 - 493 aa - 493 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.1842+/-0.000428; mu= 15.7987+/- 0.026
 mean_var=203.7612+/-44.692, 0's: 0 Z-trim(117.2): 235  B-trim: 1395 in 1/57
 Lambda= 0.089849
 statistics sampled from 28755 (29076) to 28755 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.341), width:  16
 Scan time: 10.140

The best scores are:                                      opt bits E(85289)
NP_741983 (OMIM: 617007) tripartite motif-containi ( 493) 3451 460.6 4.6e-129
XP_011542755 (OMIM: 617007) PREDICTED: tripartite  ( 343) 2351 317.8 3.2e-86
XP_005273509 (OMIM: 617007) PREDICTED: tripartite  ( 298) 1778 243.4 6.7e-64
NP_001291424 (OMIM: 617007) tripartite motif-conta ( 266) 1087 153.8 5.8e-37
NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488)  670 100.1 1.5e-20
XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 555)  670 100.2 1.6e-20
NP_060677 (OMIM: 616755) E3 ubiquitin-protein liga ( 475)  663 99.2 2.8e-20
NP_892030 (OMIM: 616017) E3 ubiquitin-protein liga ( 500)  643 96.6 1.7e-19
NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468)  642 96.4 1.8e-19
NP_001268380 (OMIM: 612548) E3 ubiquitin-protein l ( 487)  596 90.5 1.2e-17
NP_835226 (OMIM: 612548) E3 ubiquitin-protein liga ( 487)  596 90.5 1.2e-17
XP_011514091 (OMIM: 612548) PREDICTED: E3 ubiquiti ( 486)  595 90.4 1.3e-17
NP_001268379 (OMIM: 612548) E3 ubiquitin-protein l ( 486)  595 90.4 1.3e-17
XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477)  572 87.4 9.9e-17
XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477)  572 87.4 9.9e-17
NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477)  572 87.4 9.9e-17
NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477)  572 87.4 9.9e-17
XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477)  572 87.4 9.9e-17
NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485)  568 86.9 1.4e-16
NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475)  557 85.4 3.8e-16
XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450)  512 79.6 2.1e-14
XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467)  478 75.2 4.6e-13
NP_001008275 (OMIM: 613288) tripartite motif-conta ( 477)  464 73.4 1.6e-12
NP_006769 (OMIM: 605701) tripartite motif-containi ( 481)  448 71.3 6.9e-12
NP_477514 (OMIM: 607564) tripartite motif-containi ( 488)  438 70.0 1.7e-11
NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516)  438 70.1 1.8e-11
NP_291027 (OMIM: 610530) E3 ubiquitin-protein liga ( 630)  432 69.4 3.4e-11
NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498)  416 67.2 1.2e-10
NP_001186502 (OMIM: 606559) E3 ubiquitin-protein l ( 494)  413 66.8 1.6e-10
XP_011512524 (OMIM: 605701) PREDICTED: tripartite  ( 499)  412 66.7 1.8e-10
XP_011512525 (OMIM: 605701) PREDICTED: tripartite  ( 499)  412 66.7 1.8e-10
XP_011512523 (OMIM: 605701) PREDICTED: tripartite  ( 499)  412 66.7 1.8e-10
NP_542783 (OMIM: 616017) E3 ubiquitin-protein liga ( 341)  404 65.4   3e-10
NP_439893 (OMIM: 605701) tripartite motif-containi ( 395)  398 64.7 5.5e-10
NP_001317412 (OMIM: 616755) E3 ubiquitin-protein l ( 354)  394 64.1 7.4e-10
XP_006714995 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 520)  393 64.2   1e-09
XP_006714992 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 543)  393 64.3   1e-09
NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518)  392 64.1 1.1e-09
XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391)  386 63.1 1.6e-09
NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343)  385 62.9 1.6e-09
NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488)  384 63.0 2.2e-09
NP_067629 (OMIM: 605684) tripartite motif-containi ( 488)  384 63.0 2.2e-09
NP_001288073 (OMIM: 616017) E3 ubiquitin-protein l ( 296)  379 62.1 2.6e-09
NP_963921 (OMIM: 610530) E3 ubiquitin-protein liga ( 518)  380 62.5 3.2e-09
XP_006714993 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 541)  380 62.6 3.3e-09
XP_006714994 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 525)  375 61.9 5.1e-09
XP_016857119 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 544)  373 61.7 6.2e-09
XP_005249433 (OMIM: 600830) PREDICTED: tripartite  ( 539)  364 60.5 1.4e-08
XP_005249434 (OMIM: 600830) PREDICTED: tripartite  ( 539)  364 60.5 1.4e-08
NP_001229712 (OMIM: 600830) tripartite motif-conta ( 539)  364 60.5 1.4e-08


>>NP_741983 (OMIM: 617007) tripartite motif-containing p  (493 aa)
 initn: 3451 init1: 3451 opt: 3451  Z-score: 2438.1  bits: 460.6 E(85289): 4.6e-129
Smith-Waterman score: 3451; 100.0% identity (100.0% similar) in 493 aa overlap (1-493:1-493)

               10        20        30        40        50        60
pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD LQMEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRVWKKMLASVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 LQMEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRVWKKMLASVE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD SVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFSQGSHAWEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 SVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFSQGSHAWEV
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD ALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 ALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD VLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEVRPYFYLGGARGAGPPEPLRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_741 VLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEVRPYFYLGGARGAGPPEPLRI
              430       440       450       460       470       480

              490   
pF1KSD CPLHISVKEELDG
       :::::::::::::
NP_741 CPLHISVKEELDG
              490   

>>XP_011542755 (OMIM: 617007) PREDICTED: tripartite moti  (343 aa)
 initn: 2351 init1: 2351 opt: 2351  Z-score: 1669.0  bits: 317.8 E(85289): 3.2e-86
Smith-Waterman score: 2351; 100.0% identity (100.0% similar) in 343 aa overlap (151-493:1-343)

              130       140       150       160       170       180
pF1KSD CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA
                                     ::::::::::::::::::::::::::::::
XP_011                               MEHALREKAKAFWAMRRSYEAIAKHNQVEA
                                             10        20        30

              190       200       210       220       230       240
pF1KSD AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
               40        50        60        70        80        90

              250       260       270       280       290       300
pF1KSD LQMEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRVWKKMLASVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQMEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRVWKKMLASVE
              100       110       120       130       140       150

              310       320       330       340       350       360
pF1KSD SVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFSQGSHAWEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFSQGSHAWEV
              160       170       180       190       200       210

              370       380       390       400       410       420
pF1KSD ALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPL
              220       230       240       250       260       270

              430       440       450       460       470       480
pF1KSD VLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEVRPYFYLGGARGAGPPEPLRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEVRPYFYLGGARGAGPPEPLRI
              280       290       300       310       320       330

              490   
pF1KSD CPLHISVKEELDG
       :::::::::::::
XP_011 CPLHISVKEELDG
              340   

>>XP_005273509 (OMIM: 617007) PREDICTED: tripartite moti  (298 aa)
 initn: 1763 init1: 1763 opt: 1778  Z-score: 1268.2  bits: 243.4 E(85289): 6.7e-64
Smith-Waterman score: 1778; 91.0% identity (93.8% similar) in 289 aa overlap (1-281:1-289)

               10        20        30        40        50        60
pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
              190       200       210       220       230       240

              250          260           270        280       290  
pF1KSD LQMEMKEDDVSFLM---KHKSRK---RRLF-CTMEPE-PVQPGMLIDVCKYLGSLQYRVW
       ::::::::::::::   .: .:    :. . : . :  :. : .  :.:           
XP_005 LQMEMKEDDVSFLMTLLHHGARASPARHAYRCLQVPGLPAVPRLEEDACICGICTLQL  
              250       260       270       280       290          

            300       310       320       330       340       350  
pF1KSD KKMLASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFS

>>NP_001291424 (OMIM: 617007) tripartite motif-containin  (266 aa)
 initn: 1073 init1: 1073 opt: 1087  Z-score: 784.6  bits: 153.8 E(85289): 5.8e-37
Smith-Waterman score: 1485; 79.9% identity (82.7% similar) in 289 aa overlap (1-281:1-257)

               10        20        30        40        50        60
pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPTCPVC
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELLC
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD CSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEA
       :::::::::::::::::::::::::                                :::
NP_001 CSCQADPRHQGHRVQPVKDTAHDFR--------------------------------VEA
              130       140                                        

              190       200       210       220       230       240
pF1KSD AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHEIER
      150       160       170       180       190       200        

              250          260           270        280       290  
pF1KSD LQMEMKEDDVSFLM---KHKSRK---RRLF-CTMEPE-PVQPGMLIDVCKYLGSLQYRVW
       ::::::::::::::   .: .:    :. . : . :  :. : .  :.:           
NP_001 LQMEMKEDDVSFLMTLLHHGARASPARHAYRCLQVPGLPAVPRLEEDACICGICTLQL  
      210       220       230       240       250       260        

            300       310       320       330       340       350  
pF1KSD KKMLASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSSAPCLLGSRVFS

>>NP_742013 (OMIM: 605700) E3 ubiquitin-protein ligase T  (488 aa)
 initn: 570 init1: 186 opt: 670  Z-score: 489.9  bits: 100.1 E(85289): 1.5e-20
Smith-Waterman score: 670; 30.7% identity (58.8% similar) in 486 aa overlap (14-482:22-483)

                       10        20        30        40        50  
pF1KSD         MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWE-V
                            ... :  :.:: . ... : ..::::::..:..: :: .
NP_742 MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL
               10        20        30        40        50        60

              60        70        80        90       100       110 
pF1KSD QVSPTCPVCKDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLF
       . .  ::::.  .   .:: :. :...::  . .. ....  . :   .:  :.  ::::
NP_742 ERDFPCPVCRKTSRYRSLRPNRQLGSMVE--IAKQLQAVK-RKIRDESLCPQHHEALSLF
               70        80          90        100       110       

             120       130       140       150       160       170 
pF1KSD CLEDKELLCCSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKAFWAMRRSYEA
       : ::.: .:  :  .  :..: : :. :...... : ..  . :..: . .   . : : 
NP_742 CYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEK
       120       130       140       150       160       170       

             180          190       200       210       220        
pF1KSD IAKHNQVEAAWLEGRIRQ---EFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLT
         : ....   .:.: .:   ::..:.. :  :.:..:. . :: ..      :.  .: 
NP_742 --KPGELKRL-VESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLG
         180        190       200       210       220       230    

      230          240           250       260       270       280 
pF1KSD EETEVLAH---EIER--LQ--MEMKEDDVSFLMKHKSRKRRLFCTMEPEPVQPGMLIDVC
       .. . :::   :.:   ::  .:: .:  : : : .. :     :::   :.    :.. 
NP_742 DKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVK-----TMEVTSVS----IELE
          240       250       260       270            280         

               290       300       310       320       330         
pF1KSD KYLGSL--QYRVWKKMLASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQ--VENPE
       : ....  :: . .:.: .. .   ..::.::   : .:.:  ::     :..   ..:.
NP_742 KNFSNFPRQYFALRKILKQLIA-DVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPR
         290       300        310       320       330       340    

       340       350       360       370       380       390       
pF1KSD RFSSAPCLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFW
       ::.  ::.:... :..: : ::: .:    : ::: :   :: ..    .   .:  :.:
NP_742 RFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCR---DSVSRKGELTPLPET--GYW
          350       360       370       380          390           

       400       410       420        430       440       450      
pF1KSD YVCRTQGVEGDHCVTSDPATSPLVLAI-PRRLRVELECEEGELSFYDAERHCHLYTFHAR
          :..  .::. ...    .:: . . :.:. . :. : : ::::..  . :.:::   
NP_742 ---RVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDT
        400       410       420       430       440       450      

         460       470       480       490   
pF1KSD FGE-VRPYFYLGGARGAGPPEPLRICPLHISVKEELDG
       : : . : :: :   :     :: : :           
NP_742 FTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE      
        460       470       480              

>>XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr  (555 aa)
 initn: 507 init1: 219 opt: 670  Z-score: 489.3  bits: 100.2 E(85289): 1.6e-20
Smith-Waterman score: 670; 29.0% identity (58.7% similar) in 489 aa overlap (12-485:82-555)

                                  10        20        30        40 
pF1KSD                    MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFC
                                     ::..:.::::..: . ..: :.: : : ::
XP_016 GGEAAAATGSSDSAGSGLRGCAGPKRWLLSSRGLKDELLCSICLSIYQDPVSLGCEHYFC
              60        70        80        90       100       110 

                 50        60         70        80        90       
pF1KSD RGCVSRCW---EVQVSPTCPVCKDR-ASPADLRTNHTLNNLVEKLLREEAEGARWTSYRF
       : :... :   :.: .  :: :.   : :: :  .  : :.::.      . :  .. : 
XP_016 RRCITEHWVRQEAQGARDCPECRRTFAEPA-LAPSLKLANIVERYSSFPLD-AILNARRA
             120       130       140        150       160          

       100       110       120       130       140       150       
pF1KSD SRVCRLHRGQLSLFCLEDKELLCCSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHAL--
       .: :. :  ...:::: :. :::  :.    :. :.:  . :.  ... . ... .::  
XP_016 ARPCQAH-DKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQD
     170        180       190       200       210       220        

           160       170       180       190       200       210   
pF1KSD --REKAKAFWAMRRSYEAIAKHNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEET
         ::...:.  ..:.     . ..     :.  : . :..:...:: ...:.:. .  .:
XP_016 SEREHTEALQLLKRQLAETKSSTKS----LRTTIGEAFERLHRLLRERQKAMLEELEADT
      230       240       250           260       270       280    

           220       230       240       250        260       270  
pF1KSD RQKQLLADEKMKQLTEETEVLAHEIERLQMEMKEDDV-SFLMKHKSRKRRLFCTMEPEPV
        .     ..:... ... . . .  . :: .. : :  .::    : ..::   .. :  
XP_016 ARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIH-ETN
          290       300       310       320       330       340    

            280       290       300         310       320       330
pF1KSD QPGMLIDVCKYLGSLQYRVWKKMLASVESVP--FSFDPNTAAGWLSVSDDLTSVTNHGYR
            . . :: : ::: .::... ... ::  ...::.::   : .::: : :.  . .
XP_016 LTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLH
           350       360       370       380       390       400   

                340       350       360       370       380        
pF1KSD VQV--ENPERFSSAPCLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSC
        :   ..:.::.    .:::..::.: : :::...   .: .:...      : ... : 
XP_016 PQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHE-----AASRKGSI
           410       420       430       440       450             

      390       400       410       420       430       440        
pF1KSD YHDTRSGFWYVCRTQGVEGDHCVTSDPATSPLVLAIPRRLRVELECEEGELSFYDAERHC
         .   ::. .   .: . . :  ..: :   :     .. : :. ..: : ::.:.   
XP_016 QIQPSRGFYCIVMHDGNQYSAC--TEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMS
      460       470       480         490       500       510      

      450        460       470        480       490   
pF1KSD HLYTFHARF-GEVRPYFYLGGARGAGPP-EPLRICPLHISVKEELDG
        ::::. .: :..  ::  : ... :   .::::  ..:        
XP_016 WLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI        
        520       530       540       550             

>>NP_060677 (OMIM: 616755) E3 ubiquitin-protein ligase T  (475 aa)
 initn: 486 init1: 219 opt: 663  Z-score: 485.1  bits: 99.2 E(85289): 2.8e-20
Smith-Waterman score: 663; 29.0% identity (58.5% similar) in 487 aa overlap (14-485:4-475)

               10        20        30        40           50       
pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCW---EVQVSPTC
                    :.:.::::..: . ..: :.: : : ::: :... :   :.: .  :
NP_060           MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDC
                         10        20        30        40        50

        60         70        80        90       100       110      
pF1KSD PVCKDR-ASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDK
       : :.   : :: :  .  : :.::.      . :  .. : .: :. :  ...:::: :.
NP_060 PECRRTFAEPA-LAPSLKLANIVERYSSFPLD-AILNARRAARPCQAH-DKVKLFCLTDR
               60         70        80         90        100       

        120       130       140       150           160       170  
pF1KSD ELLCCSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHAL----REKAKAFWAMRRSYEAI
        :::  :.    :. :.:  . :.  ... . ... .::    ::...:.  ..:.    
NP_060 ALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAET
       110       120       130       140       150       160       

            180       190       200       210       220       230  
pF1KSD AKHNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETE
        . ..     :.  : . :..:...:: ...:.:. .  .: .     ..:... ... .
NP_060 KSSTKS----LRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLR
       170           180       190       200       210       220   

            240       250        260       270       280       290 
pF1KSD VLAHEIERLQMEMKEDDV-SFLMKHKSRKRRLFCTMEPEPVQPGMLIDVCKYLGSLQYRV
        . .  . :: .. : :  .::    : ..::   .. :       . . :: : ::: .
NP_060 KVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIH-ETNLTYEDFPTSKYTGPLQYTI
           230       240       250       260        270       280  

             300         310       320       330         340       
pF1KSD WKKMLASVESVP--FSFDPNTAAGWLSVSDDLTSVTNHGYRVQV--ENPERFSSAPCLLG
       ::... ... ::  ...::.::   : .::: : :.  . . :   ..:.::.    .::
NP_060 WKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLG
            290       300       310       320       330       340  

       350       360       370       380       390       400       
pF1KSD SRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEG
       :..::.: : :::...   .: .:...      : ... :   .   ::. .   .: . 
NP_060 SEAFSSGVHYWEVVVAEKTQWVIGLAHE-----AASRKGSIQIQPSRGFYCIVMHDGNQY
            350       360       370            380       390       

       410       420       430       440       450        460      
pF1KSD DHCVTSDPATSPLVLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARF-GEVRPYFYL
       . :  ..: :   :     .. : :. ..: : ::.:.    ::::. .: :..  ::  
NP_060 SAC--TEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSP
       400         410       420       430       440       450     

        470        480       490   
pF1KSD GGARGAGPP-EPLRICPLHISVKEELDG
       : ... :   .::::  ..:        
NP_060 GQSHANGKNVQPLRINTVRI        
         460       470             

>>NP_892030 (OMIM: 616017) E3 ubiquitin-protein ligase T  (500 aa)
 initn: 541 init1: 161 opt: 643  Z-score: 470.9  bits: 96.6 E(85289): 1.7e-19
Smith-Waterman score: 643; 29.3% identity (56.2% similar) in 505 aa overlap (1-484:17-498)

                               10            20        30        40
pF1KSD                 MERSPDVSPGPSR----SFKEELLCAVCYDPFRDAVTLRCGHNF
                       .: . ...  ::.    ..  :: : .: : ::: . : :::::
NP_892 MEVSTNPSSNIDPGDYVEMNDSITHLPSKVVIQDITMELHCPLCNDWFRDPLMLSCGHNF
               10        20        30        40        50        60

               50         60        70        80        90         
pF1KSD CRGCVSRCWEVQVSPT-CPVCKDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSR
       :..:..  :..:.. : :: ::   .  .   : .:..::::.        .    .   
NP_892 CEACIQDFWRLQAKETFCPECKMLCQYNNCTFNPVLDKLVEKI-------KKLPLLKGHP
               70        80        90       100              110   

     100       110       120          130       140       150      
pF1KSD VCRLHRGQLSLFCLEDKELLCCSCQADPR---HQGHRVQPVKDTAHDFRAKCRNMEHALR
        :  :  .:.::   : .:.: .:. : :    :...   ..:..: :  .   ..  :.
NP_892 QCPEHGENLKLFSKPDGKLICFQCK-DARLSVGQSKEFLQISDAVHFFTEELAIQQGQLE
           120       130        140       150       160       170  

        160        170       180       190       200       210     
pF1KSD EKAKAFWAMRR-SYEAIAKHNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQ
          : . ..:  . :::: :.. .   :. .. .:: ::..::. .:. ::  . :: . 
NP_892 TTLKELQTLRNMQKEAIAAHKENKLH-LQQHVSMEFLKLHQFLHSKEKDILTELREEGKA
            180       190        200       210       220       230 

         220       230       240              250       260        
pF1KSD KQLLADEKMKQLTEETEVLAHEIERLQMEMKED-------DVSFLMKHKSRKRRLFCTME
        .   . ...:: :.  .    .  .: . ...       :.. :..   .  ... : :
NP_892 LNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVLATRE
             240       250       260       270       280       290 

      270       280       290       300         310       320      
pF1KSD PEPVQPGMLIDVCKYLGSLQYRVWKKMLASVES--VPFSFDPNTAAGWLSVSDDLTSVTN
             .  ... .: : .:: ::..:  ..     :...::.::   : .: . :::  
NP_892 ----LISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVW-
                 300       310       320       330       340       

          330       340       350       360       370       380    
pF1KSD HG--YRVQVENPERFSSAPCLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGH
       ::   ... ..::::.:.  .:::: :..:.  ::: ..   .: :::::  ..   .: 
NP_892 HGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVR--ESIIRKG-
        350       360       370       380       390         400    

          390       400       410       420       430       440    
pF1KSD SHSCYHDTRSGFWYVCRTQGVEGDHCVTSDPATSPLVLAIPRRLRVELECEEGELSFYDA
         ::    ..::: . : .. . :  . . :. :  .     .. . :. : :.::::.:
NP_892 --SCPLTPEQGFWLL-RLRN-QTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNA
             410        420        430       440       450         

          450        460       470       480       490   
pF1KSD ERHCHLYTFHARFGE-VRPYFYLGGARGAGPPEPLRICPLHISVKEELDG
       .   :.:::   : : . :::      :.   :::.:  ::         
NP_892 KTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHI--LHPQ       
     460       470       480       490         500       

>>NP_660215 (OMIM: 607868) E3 ubiquitin-protein ligase T  (468 aa)
 initn: 593 init1: 223 opt: 642  Z-score: 470.4  bits: 96.4 E(85289): 1.8e-19
Smith-Waterman score: 740; 31.2% identity (57.4% similar) in 481 aa overlap (8-481:3-455)

               10        20        30        40        50          
pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSP-TCPV
              .:  : ...::  ::.: : : : :   ::::::: :. :::    .: .:: 
NP_660      MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPE
                    10        20        30        40        50     

      60        70        80        90       100       110         
pF1KSD CKDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELL
       :.. .   .:: :. : ...:   : .       :   . ::  ::  :. :: .. .::
NP_660 CRELSPQRNLRPNRPLAKMAEMARRLHPP-----SPVPQGVCPAHREPLAAFCGDELRLL
          60        70        80             90       100       110

     120       130       140        150       160       170        
pF1KSD CCSCQADPRHQGHRVQPVKDTAHDFRAKC-RNMEHALREKAKAFWAMRRSYEA-IAKHNQ
       : .:. . .: .:::.:..:.:.:..::  ...::  ..   :.  . .. :. .  ...
NP_660 CAACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKM
              120       130       140       150       160       170

       180       190       200       210       220       230       
pF1KSD VEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLAHE
       ::.   .  .  ::..::..:  ::: .:. . ::  .      :   .: ...  ::. 
NP_660 VESQ--RQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAEL
                180       190       200       210       220        

       240       250       260        270       280       290      
pF1KSD IERLQMEMKEDDVSFLMKHKSRKRRLF-CTMEPEPVQPGMLIDVCKYLGSLQYRVWKKML
       : .:. . .   ...:.  :.  ::.    ..:  : :  :  ::.  : ..  . ... 
NP_660 IAELEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVE--TLRRFR
      230       240       250       260       270       280        

        300       310       320       330        340       350     
pF1KSD ASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQV-ENPERFSSAPCLLGSRVFSQGS
       ..:     ..::.::   : .:.:  ::     :  . ..::::. .::.::.. :..: 
NP_660 GDV-----TLDPDTANPELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGR
             290       300       310       320       330       340 

         360       370       380       390       400       410     
pF1KSD HAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQGVEGDHCVTSDP
       : ::: .:   :: .:: :   .   .:.      .. .::: .       :..  .:. 
NP_660 HYWEVEVGDRTSWALGVCRENVNRKEKGEL-----SAGNGFWILVFL----GSYYNSSER
             350       360       370            380           390  

         420       430       440       450         460       470   
pF1KSD ATSPLVLAIPRRLRVELECEEGELSFYDAERHCHLYTF-HARF-GEVRPYFYLGGARGAG
       : .::    :::. . :. : :.::::.:     :. : .  : : .:: :    .  ..
NP_660 ALAPLR-DPPRRVGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLF----SPLSS
             400       410       420       430       440           

           480       490    
pF1KSD PPEPLRICPLHISVKEELDG 
        : :. ::             
NP_660 SPTPMTICRPKGGSGDTLAPQ
       450       460        

>>NP_001268380 (OMIM: 612548) E3 ubiquitin-protein ligas  (487 aa)
 initn: 497 init1: 172 opt: 596  Z-score: 438.0  bits: 90.5 E(85289): 1.2e-17
Smith-Waterman score: 596; 28.6% identity (57.4% similar) in 472 aa overlap (15-462:10-452)

               10        20        30        40         50         
pF1KSD MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGC-VSRCWEVQVSPTCPV
                     ....: : .: . :.. . :.:::..:.:: ::   ....   :::
NP_001      MAWQVSLPELEDRLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPV
                    10        20        30        40        50     

      60        70        80        90       100       110         
pF1KSD CKDRASPADLRTNHTLNNLVEKLLREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDKELL
       :.. .. ..   : .:  ..: :        :  .    .::  ::. ::::: .:.::.
NP_001 CRQAVDGSSSLPNVSLARVIEAL--------RLPGDPEPKVCVHHRNPLSLFCEKDQELI
          60        70                80        90       100       

     120       130       140       150       160           170     
pF1KSD CCSCQADPRHQGHRVQPVKDTAHDFRAKCRNMEHALREKAKA----FWAMRRSYEAIAKH
       :  :     :: : : ::. .   .. .   .   :... :     .  .  .   :...
NP_001 CGLCGLLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNE
       110       120       130       140       150       160       

         180       190       200       210       220       230     
pF1KSD NQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKMKQLTEETEVLA
       ..: . :.   ::.::..:....  :.   :.... .::      : ...:     : ::
NP_001 SDVFS-WV---IRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLA
       170           180       190       200       210       220   

         240       250               260       270       280       
pF1KSD HEIERLQMEMKEDDVSFLMKHKS--------RKRRLFCTMEPEPVQPGMLIDVCKYLGSL
       .    :..  .::  .:. : .:        . : :  .. :   .::.      . ...
NP_001 QAECVLEQFGNEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGL------HQADI
           230       240       250       260       270             

       290       300         310       320       330         340   
pF1KSD QYRVWKKMLASVESVP--FSFDPNTAAGWLSVSDDLTSVTNHGYRVQ--VENPERFSSAP
       .  :::... .:  .:  ...:: ::   : .:   ..:.. :  .:  . .::::. . 
NP_001 KLTVWKRLFRKVLPAPEPLKLDPATAHPLLELSKG-NTVVQCGLLAQRRASQPERFDYST
       280       290       300       310        320       330      

           350       360       370       380       390       400   
pF1KSD CLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVCRTQ
       :.:.:: :: : : :::..:. ..::.::..     :. ... .  .. . : : .   .
NP_001 CVLASRGFSCGRHYWEVVVGSKSDWRLGVIK-----GTASRKGKLNRSPEHGVWLIGLKE
        340       350       360            370       380       390 

             410       420        430       440       450          
pF1KSD G--VEGDHCVTSDPATSPLVLAI-PRRLRVELECEEGELSFYDAERHCHL---YTFHARF
       :   :.  :    : . :: .:  :.:. . :. :.:::.:.::.:   :   :::.: :
NP_001 GRVYEAFAC----PRV-PLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADF
             400            410       420       430       440      

        460       470       480       490       
pF1KSD -GEVRPYFYLGGARGAGPPEPLRICPLHISVKEELDG    
        :.. :                                   
NP_001 QGKLYPILDTCWHERGSNSLPMVLPPPSGPGPLSPEQPTKL
        450       460       470       480       




493 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 19:01:22 2016 done: Thu Nov  3 19:01:24 2016
 Total Scan time: 10.140 Total Display time:  0.070

Function used was FASTA [36.3.4 Apr, 2011]
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