FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1125, 1186 aa 1>>>pF1KSDA1125 1186 - 1186 aa - 1186 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 14.1085+/-0.000493; mu= -20.6307+/- 0.031 mean_var=449.3443+/-95.173, 0's: 0 Z-trim(120.6): 100 B-trim: 543 in 1/56 Lambda= 0.060504 statistics sampled from 35897 (36012) to 35897 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.723), E-opt: 0.2 (0.422), width: 16 Scan time: 16.290 The best scores are: opt bits E(85289) XP_016883256 (OMIM: 615713) PREDICTED: protein kin (1186) 7899 705.1 6.7e-202 XP_005260423 (OMIM: 615713) PREDICTED: protein kin (1186) 7899 705.1 6.7e-202 XP_016883257 (OMIM: 615713) PREDICTED: protein kin (1186) 7899 705.1 6.7e-202 XP_016883252 (OMIM: 615713) PREDICTED: protein kin (1205) 7899 705.1 6.8e-202 NP_001268712 (OMIM: 615713) protein kinase C-bindi (1206) 7899 705.1 6.8e-202 XP_011527053 (OMIM: 615713) PREDICTED: protein kin (1214) 7609 679.8 2.9e-194 NP_001268702 (OMIM: 615713) protein kinase C-bindi (1214) 7609 679.8 2.9e-194 XP_006723825 (OMIM: 615713) PREDICTED: protein kin (1214) 7609 679.8 2.9e-194 XP_005260417 (OMIM: 615713) PREDICTED: protein kin (1214) 7609 679.8 2.9e-194 XP_016883250 (OMIM: 615713) PREDICTED: protein kin (1214) 7609 679.8 2.9e-194 XP_006723823 (OMIM: 615713) PREDICTED: protein kin (1233) 7609 679.8 2.9e-194 NP_001268704 (OMIM: 615713) protein kinase C-bindi (1234) 7609 679.8 2.9e-194 XP_011527051 (OMIM: 615713) PREDICTED: protein kin (1239) 7609 679.8 2.9e-194 XP_005260413 (OMIM: 615713) PREDICTED: protein kin (1241) 7609 679.8 2.9e-194 XP_005260415 (OMIM: 615713) PREDICTED: protein kin (1233) 7562 675.7 5e-193 XP_016883253 (OMIM: 615713) PREDICTED: protein kin (1198) 7473 667.9 1.1e-190 XP_016883249 (OMIM: 615713) PREDICTED: protein kin (1218) 7473 667.9 1.1e-190 XP_016883266 (OMIM: 615713) PREDICTED: protein kin (1118) 7435 664.6 1e-189 XP_016883260 (OMIM: 615713) PREDICTED: protein kin (1161) 7358 657.9 1.1e-187 XP_016883259 (OMIM: 615713) PREDICTED: protein kin (1161) 7358 657.9 1.1e-187 XP_016883261 (OMIM: 615713) PREDICTED: protein kin (1161) 7358 657.9 1.1e-187 NP_001268707 (OMIM: 615713) protein kinase C-bindi (1181) 7358 657.9 1.1e-187 NP_001268701 (OMIM: 615713) protein kinase C-bindi (1186) 7358 657.9 1.1e-187 XP_016883263 (OMIM: 615713) PREDICTED: protein kin (1146) 7145 639.3 4.3e-182 XP_011527056 (OMIM: 615713) PREDICTED: protein kin (1189) 7068 632.5 4.6e-180 XP_016883255 (OMIM: 615713) PREDICTED: protein kin (1189) 7068 632.5 4.6e-180 XP_011527055 (OMIM: 615713) PREDICTED: protein kin (1189) 7068 632.5 4.6e-180 XP_006723829 (OMIM: 615713) PREDICTED: protein kin (1189) 7068 632.5 4.6e-180 XP_005260421 (OMIM: 615713) PREDICTED: protein kin (1189) 7068 632.5 4.6e-180 XP_006723826 (OMIM: 615713) PREDICTED: protein kin (1208) 7068 632.5 4.7e-180 XP_005260419 (OMIM: 615713) PREDICTED: protein kin (1209) 7068 632.5 4.7e-180 XP_016883251 (OMIM: 615713) PREDICTED: protein kin (1214) 7068 632.5 4.7e-180 XP_016883258 (OMIM: 615713) PREDICTED: protein kin (1173) 6932 620.7 1.7e-176 XP_016883254 (OMIM: 615713) PREDICTED: protein kin (1193) 6932 620.7 1.7e-176 XP_016883267 (OMIM: 615713) PREDICTED: protein kin ( 992) 6573 589.3 4e-167 NP_036540 (OMIM: 615713) protein kinase C-binding (1160) 5583 502.9 4.8e-141 NP_001268703 (OMIM: 615713) protein kinase C-bindi (1168) 5583 502.9 4.8e-141 NP_898868 (OMIM: 615713) protein kinase C-binding (1188) 5583 502.9 4.9e-141 NP_001268705 (OMIM: 615713) protein kinase C-bindi (1107) 5114 462.0 9.6e-129 NP_898869 (OMIM: 615713) protein kinase C-binding (1135) 5042 455.7 7.7e-127 XP_016883264 (OMIM: 615713) PREDICTED: protein kin (1143) 5042 455.7 7.7e-127 XP_016883262 (OMIM: 615713) PREDICTED: protein kin (1147) 5042 455.7 7.7e-127 NP_001268706 (OMIM: 615713) protein kinase C-bindi (1163) 5042 455.7 7.8e-127 NP_001268711 (OMIM: 615713) protein kinase C-bindi (1136) 5016 453.4 3.7e-126 NP_001268700 (OMIM: 615713) protein kinase C-bindi (1054) 4573 414.7 1.5e-114 NP_001268713 (OMIM: 615713) protein kinase C-bindi (1134) 4307 391.5 1.6e-107 XP_011527054 (OMIM: 615713) PREDICTED: protein kin (1167) 4017 366.2 6.7e-100 XP_016883269 (OMIM: 615713) PREDICTED: protein kin ( 909) 3930 358.6 1.1e-97 XP_016883268 (OMIM: 615713) PREDICTED: protein kin ( 917) 3930 358.6 1.1e-97 XP_016883265 (OMIM: 615713) PREDICTED: protein kin (1126) 3881 354.3 2.4e-96 >>XP_016883256 (OMIM: 615713) PREDICTED: protein kinase (1186 aa) initn: 7899 init1: 7899 opt: 7899 Z-score: 3745.7 bits: 705.1 E(85289): 6.7e-202 Smith-Waterman score: 7899; 100.0% identity (100.0% similar) in 1186 aa overlap (1-1186:1-1186) 10 20 30 40 50 60 pF1KSD MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 pF1KSD SDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRLDTFWD :::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRLDTFWD 1150 1160 1170 1180 >>XP_005260423 (OMIM: 615713) PREDICTED: protein kinase (1186 aa) initn: 7899 init1: 7899 opt: 7899 Z-score: 3745.7 bits: 705.1 E(85289): 6.7e-202 Smith-Waterman score: 7899; 100.0% identity (100.0% similar) in 1186 aa overlap (1-1186:1-1186) 10 20 30 40 50 60 pF1KSD MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 pF1KSD SDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRLDTFWD :::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRLDTFWD 1150 1160 1170 1180 >>XP_016883257 (OMIM: 615713) PREDICTED: protein kinase (1186 aa) initn: 7899 init1: 7899 opt: 7899 Z-score: 3745.7 bits: 705.1 E(85289): 6.7e-202 Smith-Waterman score: 7899; 100.0% identity (100.0% similar) in 1186 aa overlap (1-1186:1-1186) 10 20 30 40 50 60 pF1KSD MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 pF1KSD SDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRLDTFWD :::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRLDTFWD 1150 1160 1170 1180 >>XP_016883252 (OMIM: 615713) PREDICTED: protein kinase (1205 aa) initn: 7899 init1: 7899 opt: 7899 Z-score: 3745.6 bits: 705.1 E(85289): 6.8e-202 Smith-Waterman score: 7899; 100.0% identity (100.0% similar) in 1186 aa overlap (1-1186:20-1205) 10 20 30 40 pF1KSD MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSP ::::::::::::::::::::::::::::::::::::::::: XP_016 MSLSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KSD IKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVL 70 80 90 100 110 120 110 120 130 140 150 160 pF1KSD CCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFA 130 140 150 160 170 180 170 180 190 200 210 220 pF1KSD IQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWIL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KSD HNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLV 250 260 270 280 290 300 290 300 310 320 330 340 pF1KSD WAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNS 310 320 330 340 350 360 350 360 370 380 390 400 pF1KSD AMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNF 370 380 390 400 410 420 410 420 430 440 450 460 pF1KSD DMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSA 430 440 450 460 470 480 470 480 490 500 510 520 pF1KSD SEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLD 490 500 510 520 530 540 530 540 550 560 570 580 pF1KSD RSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVY 550 560 570 580 590 600 590 600 610 620 630 640 pF1KSD TAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNP 610 620 630 640 650 660 650 660 670 680 690 700 pF1KSD VEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTV 670 680 690 700 710 720 710 720 730 740 750 760 pF1KSD HLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETP 730 740 750 760 770 780 770 780 790 800 810 820 pF1KSD VLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNS 790 800 810 820 830 840 830 840 850 860 870 880 pF1KSD SSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPST 850 860 870 880 890 900 890 900 910 920 930 940 pF1KSD STITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTM 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KSD TEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERD 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KSD RLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKS 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KSD CTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTL 1090 1100 1110 1120 1130 1140 1130 1140 1150 1160 1170 1180 pF1KSD DLSGSRETPSSILLGSNQGSDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLSGSRETPSSILLGSNQGSDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRL 1150 1160 1170 1180 1190 1200 pF1KSD DTFWD ::::: XP_016 DTFWD >>NP_001268712 (OMIM: 615713) protein kinase C-binding p (1206 aa) initn: 7899 init1: 7899 opt: 7899 Z-score: 3745.6 bits: 705.1 E(85289): 6.8e-202 Smith-Waterman score: 7899; 100.0% identity (100.0% similar) in 1186 aa overlap (1-1186:21-1206) 10 20 30 40 pF1KSD MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTS :::::::::::::::::::::::::::::::::::::::: NP_001 MHPQSLAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KSD PIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQV 70 80 90 100 110 120 110 120 130 140 150 160 pF1KSD LCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKF 130 140 150 160 170 180 170 180 190 200 210 220 pF1KSD AIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWI 190 200 210 220 230 240 230 240 250 260 270 280 pF1KSD LHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KSD VWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFN 310 320 330 340 350 360 350 360 370 380 390 400 pF1KSD SAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLN 370 380 390 400 410 420 410 420 430 440 450 460 pF1KSD FDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFS 430 440 450 460 470 480 470 480 490 500 510 520 pF1KSD ASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNL 490 500 510 520 530 540 530 540 550 560 570 580 pF1KSD DRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDV 550 560 570 580 590 600 590 600 610 620 630 640 pF1KSD YTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTN 610 620 630 640 650 660 650 660 670 680 690 700 pF1KSD PVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPT 670 680 690 700 710 720 710 720 730 740 750 760 pF1KSD VHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPET 730 740 750 760 770 780 770 780 790 800 810 820 pF1KSD PVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWN 790 800 810 820 830 840 830 840 850 860 870 880 pF1KSD SSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPS 850 860 870 880 890 900 890 900 910 920 930 940 pF1KSD TSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGT 910 920 930 940 950 960 950 960 970 980 990 1000 pF1KSD MTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQER 970 980 990 1000 1010 1020 1010 1020 1030 1040 1050 1060 pF1KSD DRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMK 1030 1040 1050 1060 1070 1080 1070 1080 1090 1100 1110 1120 pF1KSD SCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGST 1090 1100 1110 1120 1130 1140 1130 1140 1150 1160 1170 1180 pF1KSD LDLSGSRETPSSILLGSNQGSDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDLSGSRETPSSILLGSNQGSDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESR 1150 1160 1170 1180 1190 1200 pF1KSD LDTFWD :::::: NP_001 LDTFWD >>XP_011527053 (OMIM: 615713) PREDICTED: protein kinase (1214 aa) initn: 7877 init1: 7600 opt: 7609 Z-score: 3608.7 bits: 679.8 E(85289): 2.9e-194 Smith-Waterman score: 7823; 97.7% identity (97.7% similar) in 1214 aa overlap (1-1186:1-1214) 10 20 30 40 50 60 pF1KSD MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG 1090 1100 1110 1120 1130 1140 1150 1160 1170 pF1KSD S----------------DH------------SRSNKSSWSSSDEKRGSTRSDHNTSTSTK : :: ::::::::::::::::::::::::::::: XP_011 SVSKRCDKQPAYAPTTTDHQPHPNYPAQKYHSRSNKSSWSSSDEKRGSTRSDHNTSTSTK 1150 1160 1170 1180 1190 1200 1180 pF1KSD SLLPKESRLDTFWD :::::::::::::: XP_011 SLLPKESRLDTFWD 1210 >>NP_001268702 (OMIM: 615713) protein kinase C-binding p (1214 aa) initn: 7877 init1: 7600 opt: 7609 Z-score: 3608.7 bits: 679.8 E(85289): 2.9e-194 Smith-Waterman score: 7823; 97.7% identity (97.7% similar) in 1214 aa overlap (1-1186:1-1214) 10 20 30 40 50 60 pF1KSD MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG 1090 1100 1110 1120 1130 1140 1150 1160 1170 pF1KSD S----------------DH------------SRSNKSSWSSSDEKRGSTRSDHNTSTSTK : :: ::::::::::::::::::::::::::::: NP_001 SVSKRCDKQPAYAPTTTDHQPHPNYPAQKYHSRSNKSSWSSSDEKRGSTRSDHNTSTSTK 1150 1160 1170 1180 1190 1200 1180 pF1KSD SLLPKESRLDTFWD :::::::::::::: NP_001 SLLPKESRLDTFWD 1210 >>XP_006723825 (OMIM: 615713) PREDICTED: protein kinase (1214 aa) initn: 7877 init1: 7600 opt: 7609 Z-score: 3608.7 bits: 679.8 E(85289): 2.9e-194 Smith-Waterman score: 7823; 97.7% identity (97.7% similar) in 1214 aa overlap (1-1186:1-1214) 10 20 30 40 50 60 pF1KSD MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG 1090 1100 1110 1120 1130 1140 1150 1160 1170 pF1KSD S----------------DH------------SRSNKSSWSSSDEKRGSTRSDHNTSTSTK : :: ::::::::::::::::::::::::::::: XP_006 SVSKRCDKQPAYAPTTTDHQPHPNYPAQKYHSRSNKSSWSSSDEKRGSTRSDHNTSTSTK 1150 1160 1170 1180 1190 1200 1180 pF1KSD SLLPKESRLDTFWD :::::::::::::: XP_006 SLLPKESRLDTFWD 1210 >>XP_005260417 (OMIM: 615713) PREDICTED: protein kinase (1214 aa) initn: 7877 init1: 7600 opt: 7609 Z-score: 3608.7 bits: 679.8 E(85289): 2.9e-194 Smith-Waterman score: 7823; 97.7% identity (97.7% similar) in 1214 aa overlap (1-1186:1-1214) 10 20 30 40 50 60 pF1KSD MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG 1090 1100 1110 1120 1130 1140 1150 1160 1170 pF1KSD S----------------DH------------SRSNKSSWSSSDEKRGSTRSDHNTSTSTK : :: ::::::::::::::::::::::::::::: XP_005 SVSKRCDKQPAYAPTTTDHQPHPNYPAQKYHSRSNKSSWSSSDEKRGSTRSDHNTSTSTK 1150 1160 1170 1180 1190 1200 1180 pF1KSD SLLPKESRLDTFWD :::::::::::::: XP_005 SLLPKESRLDTFWD 1210 >>XP_016883250 (OMIM: 615713) PREDICTED: protein kinase (1214 aa) initn: 7877 init1: 7600 opt: 7609 Z-score: 3608.7 bits: 679.8 E(85289): 2.9e-194 Smith-Waterman score: 7823; 97.7% identity (97.7% similar) in 1214 aa overlap (1-1186:1-1214) 10 20 30 40 50 60 pF1KSD MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG 1090 1100 1110 1120 1130 1140 1150 1160 1170 pF1KSD S----------------DH------------SRSNKSSWSSSDEKRGSTRSDHNTSTSTK : :: ::::::::::::::::::::::::::::: XP_016 SVSKRCDKQPAYAPTTTDHQPHPNYPAQKYHSRSNKSSWSSSDEKRGSTRSDHNTSTSTK 1150 1160 1170 1180 1190 1200 1180 pF1KSD SLLPKESRLDTFWD :::::::::::::: XP_016 SLLPKESRLDTFWD 1210 1186 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 05:03:45 2016 done: Thu Nov 3 05:03:47 2016 Total Scan time: 16.290 Total Display time: 0.580 Function used was FASTA [36.3.4 Apr, 2011]