Result of FASTA (omim) for
pF1KSDA1169
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1169, 816 aa
1>>>pF1KSDA1169 816 - 816 aa - 816 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1543+/-0.000418; mu= 16.6686+/- 0.026
mean_var=92.8785+/-18.477, 0's: 0 Z-trim(113.1): 283 B-trim: 246 in 1/54
Lambda= 0.133081
statistics sampled from 21975 (22289) to 21975 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.61), E-opt: 0.2 (0.261), width: 16
Scan time: 12.990
The best scores are: opt bits E(85289)
XP_011536794 (OMIM: 609666) PREDICTED: two pore ca ( 816) 5349 1038.0 0
NP_060371 (OMIM: 609666) two pore calcium channel ( 816) 5349 1038.0 0
XP_011536792 (OMIM: 609666) PREDICTED: two pore ca ( 888) 5349 1038.0 0
NP_001137291 (OMIM: 609666) two pore calcium chann ( 888) 5349 1038.0 0
XP_005253963 (OMIM: 609666) PREDICTED: two pore ca ( 748) 4894 950.6 0
XP_011536795 (OMIM: 609666) PREDICTED: two pore ca ( 748) 4894 950.6 0
XP_016874970 (OMIM: 609666) PREDICTED: two pore ca ( 748) 4894 950.6 0
NP_001288143 (OMIM: 609666) two pore calcium chann ( 748) 4894 950.6 0
XP_016874971 (OMIM: 609666) PREDICTED: two pore ca ( 641) 3737 728.4 2.4e-209
XP_016874969 (OMIM: 609666) PREDICTED: two pore ca ( 870) 3075 601.4 5.6e-171
XP_005273881 (OMIM: 612163,612267) PREDICTED: two ( 751) 438 95.1 1.3e-18
XP_011543104 (OMIM: 612163,612267) PREDICTED: two ( 672) 436 94.7 1.5e-18
NP_620714 (OMIM: 612163,612267) two pore calcium c ( 752) 436 94.7 1.6e-18
XP_011543108 (OMIM: 612163,612267) PREDICTED: two ( 566) 426 92.7 4.9e-18
XP_005273883 (OMIM: 612163,612267) PREDICTED: two ( 667) 422 92.0 9.6e-18
XP_011543107 (OMIM: 612163,612267) PREDICTED: two ( 570) 421 91.7 9.7e-18
XP_016872818 (OMIM: 612163,612267) PREDICTED: two ( 678) 356 79.3 6.4e-14
XP_016872817 (OMIM: 612163,612267) PREDICTED: two ( 679) 354 78.9 8.3e-14
XP_011543109 (OMIM: 612163,612267) PREDICTED: two ( 520) 324 73.1 3.6e-12
XP_005273888 (OMIM: 612163,612267) PREDICTED: two ( 521) 324 73.1 3.6e-12
XP_005273887 (OMIM: 612163,612267) PREDICTED: two ( 521) 324 73.1 3.6e-12
NP_001120693 (OMIM: 108500,141500,183086,601011,61 (2261) 326 73.8 9.3e-12
NP_001167551 (OMIM: 108500,141500,183086,601011,61 (2263) 326 73.8 9.3e-12
NP_000059 (OMIM: 108500,141500,183086,601011,61710 (2266) 326 73.8 9.3e-12
NP_075461 (OMIM: 108500,141500,183086,601011,61710 (2512) 326 73.9 1e-11
NP_001120694 (OMIM: 108500,141500,183086,601011,61 (2506) 321 72.9 2e-11
NP_001230741 (OMIM: 601012,614860) voltage-depende (2237) 302 69.2 2.2e-10
XP_016870609 (OMIM: 601012,614860) PREDICTED: volt (2337) 302 69.2 2.3e-10
XP_016870607 (OMIM: 601012,614860) PREDICTED: volt (2338) 302 69.2 2.3e-10
NP_000709 (OMIM: 601012,614860) voltage-dependent (2339) 302 69.2 2.3e-10
XP_011517295 (OMIM: 601012,614860) PREDICTED: volt (2341) 302 69.2 2.3e-10
XP_016870604 (OMIM: 601012,614860) PREDICTED: volt (2343) 302 69.2 2.3e-10
XP_016870608 (OMIM: 601012,614860) PREDICTED: volt (1745) 300 68.8 2.4e-10
XP_011517296 (OMIM: 601012,614860) PREDICTED: volt (2338) 300 68.9 3e-10
XP_016870606 (OMIM: 601012,614860) PREDICTED: volt (2340) 300 68.9 3e-10
XP_016870605 (OMIM: 601012,614860) PREDICTED: volt (2342) 300 68.9 3e-10
XP_011517294 (OMIM: 601012,614860) PREDICTED: volt (2343) 300 68.9 3e-10
XP_011517293 (OMIM: 601012,614860) PREDICTED: volt (2344) 300 68.9 3e-10
NP_001192223 (OMIM: 601013) voltage-dependent R-ty (2251) 290 66.9 1.1e-09
NP_000712 (OMIM: 601013) voltage-dependent R-type (2270) 290 66.9 1.1e-09
NP_001192222 (OMIM: 601013) voltage-dependent R-ty (2313) 290 66.9 1.1e-09
XP_016857739 (OMIM: 601013) PREDICTED: voltage-dep (2396) 290 67.0 1.2e-09
XP_016857738 (OMIM: 601013) PREDICTED: voltage-dep (2415) 290 67.0 1.2e-09
XP_016857737 (OMIM: 601013) PREDICTED: voltage-dep (2436) 290 67.0 1.2e-09
XP_016857736 (OMIM: 601013) PREDICTED: voltage-dep (2439) 290 67.0 1.2e-09
XP_016857734 (OMIM: 601013) PREDICTED: voltage-dep (2454) 290 67.0 1.2e-09
XP_016857735 (OMIM: 601013) PREDICTED: voltage-dep (2454) 290 67.0 1.2e-09
XP_016857740 (OMIM: 601013) PREDICTED: voltage-dep (2458) 290 67.0 1.2e-09
XP_016857733 (OMIM: 601013) PREDICTED: voltage-dep (2458) 290 67.0 1.2e-09
XP_016857732 (OMIM: 601013) PREDICTED: voltage-dep (2458) 290 67.0 1.2e-09
>>XP_011536794 (OMIM: 609666) PREDICTED: two pore calciu (816 aa)
initn: 5349 init1: 5349 opt: 5349 Z-score: 5550.6 bits: 1038.0 E(85289): 0
Smith-Waterman score: 5349; 100.0% identity (100.0% similar) in 816 aa overlap (1-816:1-816)
10 20 30 40 50 60
pF1KSD MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD SSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD LLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD FFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD IVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD RQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD DELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD VFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD STVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD SHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKEEL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD VAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEW
730 740 750 760 770 780
790 800 810
pF1KSD YEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
::::::::::::::::::::::::::::::::::::
XP_011 YEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
790 800 810
>>NP_060371 (OMIM: 609666) two pore calcium channel prot (816 aa)
initn: 5349 init1: 5349 opt: 5349 Z-score: 5550.6 bits: 1038.0 E(85289): 0
Smith-Waterman score: 5349; 100.0% identity (100.0% similar) in 816 aa overlap (1-816:1-816)
10 20 30 40 50 60
pF1KSD MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD SSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD LLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD FFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 FFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD IVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 IVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD RQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD DELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD VFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD STVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 STVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD SHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKEEL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD VAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEW
730 740 750 760 770 780
790 800 810
pF1KSD YEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
::::::::::::::::::::::::::::::::::::
NP_060 YEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
790 800 810
>>XP_011536792 (OMIM: 609666) PREDICTED: two pore calciu (888 aa)
initn: 5349 init1: 5349 opt: 5349 Z-score: 5550.1 bits: 1038.0 E(85289): 0
Smith-Waterman score: 5349; 100.0% identity (100.0% similar) in 816 aa overlap (1-816:73-888)
10 20 30
pF1KSD MAVSLDDDVPLILTLDEGGSAPLAPSNGLG
::::::::::::::::::::::::::::::
XP_011 PWPSGFERELKPETISSPGYHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLG
50 60 70 80 90 100
40 50 60 70 80 90
pF1KSD QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH
110 120 130 140 150 160
100 110 120 130 140 150
pF1KSD PKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMV
170 180 190 200 210 220
160 170 180 190 200 210
pF1KSD VVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLV
230 240 250 260 270 280
220 230 240 250 260 270
pF1KSD DCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSI
290 300 310 320 330 340
280 290 300 310 320 330
pF1KSD VSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK
350 360 370 380 390 400
340 350 360 370 380 390
pF1KSD FKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNN
410 420 430 440 450 460
400 410 420 430 440 450
pF1KSD TPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLV
470 480 490 500 510 520
460 470 480 490 500 510
pF1KSD VAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLF
530 540 550 560 570 580
520 530 540 550 560 570
pF1KSD DFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASL
590 600 610 620 630 640
580 590 600 610 620 630
pF1KSD GLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNF
650 660 670 680 690 700
640 650 660 670 680 690
pF1KSD DNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAF
710 720 730 740 750 760
700 710 720 730 740 750
pF1KSD VFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERY
770 780 790 800 810 820
760 770 780 790 800 810
pF1KSD QQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQ
830 840 850 860 870 880
pF1KSD RSQTVT
::::::
XP_011 RSQTVT
>>NP_001137291 (OMIM: 609666) two pore calcium channel p (888 aa)
initn: 5349 init1: 5349 opt: 5349 Z-score: 5550.1 bits: 1038.0 E(85289): 0
Smith-Waterman score: 5349; 100.0% identity (100.0% similar) in 816 aa overlap (1-816:73-888)
10 20 30
pF1KSD MAVSLDDDVPLILTLDEGGSAPLAPSNGLG
::::::::::::::::::::::::::::::
NP_001 PWPSGFERELKPETISSPGYHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLG
50 60 70 80 90 100
40 50 60 70 80 90
pF1KSD QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH
110 120 130 140 150 160
100 110 120 130 140 150
pF1KSD PKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMV
170 180 190 200 210 220
160 170 180 190 200 210
pF1KSD VVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLV
230 240 250 260 270 280
220 230 240 250 260 270
pF1KSD DCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSI
290 300 310 320 330 340
280 290 300 310 320 330
pF1KSD VSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK
350 360 370 380 390 400
340 350 360 370 380 390
pF1KSD FKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNN
410 420 430 440 450 460
400 410 420 430 440 450
pF1KSD TPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLV
470 480 490 500 510 520
460 470 480 490 500 510
pF1KSD VAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLF
530 540 550 560 570 580
520 530 540 550 560 570
pF1KSD DFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASL
590 600 610 620 630 640
580 590 600 610 620 630
pF1KSD GLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNF
650 660 670 680 690 700
640 650 660 670 680 690
pF1KSD DNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAF
710 720 730 740 750 760
700 710 720 730 740 750
pF1KSD VFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERY
770 780 790 800 810 820
760 770 780 790 800 810
pF1KSD QQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQ
830 840 850 860 870 880
pF1KSD RSQTVT
::::::
NP_001 RSQTVT
>>XP_005253963 (OMIM: 609666) PREDICTED: two pore calciu (748 aa)
initn: 4894 init1: 4894 opt: 4894 Z-score: 5079.1 bits: 950.6 E(85289): 0
Smith-Waterman score: 4894; 100.0% identity (100.0% similar) in 748 aa overlap (69-816:1-748)
40 50 60 70 80 90
pF1KSD GGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALA
::::::::::::::::::::::::::::::
XP_005 MNYQEAAIYLQEGENNDKFFTHPKDAKALA
10 20 30
100 110 120 130 140 150
pF1KSD AYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMK
40 50 60 70 80 90
160 170 180 190 200 210
pF1KSD LRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGV
100 110 120 130 140 150
220 230 240 250 260 270
pF1KSD RRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLT
160 170 180 190 200 210
280 290 300 310 320 330
pF1KSD TANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHK
220 230 240 250 260 270
340 350 360 370 380 390
pF1KSD RTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKD
280 290 300 310 320 330
400 410 420 430 440 450
pF1KSD FYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWI
340 350 360 370 380 390
460 470 480 490 500 510
pF1KSD LVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFA
400 410 420 430 440 450
520 530 540 550 560 570
pF1KSD FLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFY
460 470 480 490 500 510
580 590 600 610 620 630
pF1KSD YSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFV
520 530 540 550 560 570
640 650 660 670 680 690
pF1KSD TLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSR
580 590 600 610 620 630
700 710 720 730 740 750
pF1KSD KNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFL
640 650 660 670 680 690
760 770 780 790 800 810
pF1KSD GRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
700 710 720 730 740
>>XP_011536795 (OMIM: 609666) PREDICTED: two pore calciu (748 aa)
initn: 4894 init1: 4894 opt: 4894 Z-score: 5079.1 bits: 950.6 E(85289): 0
Smith-Waterman score: 4894; 100.0% identity (100.0% similar) in 748 aa overlap (69-816:1-748)
40 50 60 70 80 90
pF1KSD GGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALA
::::::::::::::::::::::::::::::
XP_011 MNYQEAAIYLQEGENNDKFFTHPKDAKALA
10 20 30
100 110 120 130 140 150
pF1KSD AYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMK
40 50 60 70 80 90
160 170 180 190 200 210
pF1KSD LRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGV
100 110 120 130 140 150
220 230 240 250 260 270
pF1KSD RRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLT
160 170 180 190 200 210
280 290 300 310 320 330
pF1KSD TANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHK
220 230 240 250 260 270
340 350 360 370 380 390
pF1KSD RTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKD
280 290 300 310 320 330
400 410 420 430 440 450
pF1KSD FYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWI
340 350 360 370 380 390
460 470 480 490 500 510
pF1KSD LVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFA
400 410 420 430 440 450
520 530 540 550 560 570
pF1KSD FLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFY
460 470 480 490 500 510
580 590 600 610 620 630
pF1KSD YSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFV
520 530 540 550 560 570
640 650 660 670 680 690
pF1KSD TLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSR
580 590 600 610 620 630
700 710 720 730 740 750
pF1KSD KNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFL
640 650 660 670 680 690
760 770 780 790 800 810
pF1KSD GRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
700 710 720 730 740
>>XP_016874970 (OMIM: 609666) PREDICTED: two pore calciu (748 aa)
initn: 4894 init1: 4894 opt: 4894 Z-score: 5079.1 bits: 950.6 E(85289): 0
Smith-Waterman score: 4894; 100.0% identity (100.0% similar) in 748 aa overlap (69-816:1-748)
40 50 60 70 80 90
pF1KSD GGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALA
::::::::::::::::::::::::::::::
XP_016 MNYQEAAIYLQEGENNDKFFTHPKDAKALA
10 20 30
100 110 120 130 140 150
pF1KSD AYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMK
40 50 60 70 80 90
160 170 180 190 200 210
pF1KSD LRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGV
100 110 120 130 140 150
220 230 240 250 260 270
pF1KSD RRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLT
160 170 180 190 200 210
280 290 300 310 320 330
pF1KSD TANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHK
220 230 240 250 260 270
340 350 360 370 380 390
pF1KSD RTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKD
280 290 300 310 320 330
400 410 420 430 440 450
pF1KSD FYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWI
340 350 360 370 380 390
460 470 480 490 500 510
pF1KSD LVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFA
400 410 420 430 440 450
520 530 540 550 560 570
pF1KSD FLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFY
460 470 480 490 500 510
580 590 600 610 620 630
pF1KSD YSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFV
520 530 540 550 560 570
640 650 660 670 680 690
pF1KSD TLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSR
580 590 600 610 620 630
700 710 720 730 740 750
pF1KSD KNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFL
640 650 660 670 680 690
760 770 780 790 800 810
pF1KSD GRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
700 710 720 730 740
>>NP_001288143 (OMIM: 609666) two pore calcium channel p (748 aa)
initn: 4894 init1: 4894 opt: 4894 Z-score: 5079.1 bits: 950.6 E(85289): 0
Smith-Waterman score: 4894; 100.0% identity (100.0% similar) in 748 aa overlap (69-816:1-748)
40 50 60 70 80 90
pF1KSD GGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALA
::::::::::::::::::::::::::::::
NP_001 MNYQEAAIYLQEGENNDKFFTHPKDAKALA
10 20 30
100 110 120 130 140 150
pF1KSD AYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMK
40 50 60 70 80 90
160 170 180 190 200 210
pF1KSD LRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGV
100 110 120 130 140 150
220 230 240 250 260 270
pF1KSD RRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLT
160 170 180 190 200 210
280 290 300 310 320 330
pF1KSD TANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHK
220 230 240 250 260 270
340 350 360 370 380 390
pF1KSD RTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKD
280 290 300 310 320 330
400 410 420 430 440 450
pF1KSD FYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWI
340 350 360 370 380 390
460 470 480 490 500 510
pF1KSD LVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFA
400 410 420 430 440 450
520 530 540 550 560 570
pF1KSD FLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFY
460 470 480 490 500 510
580 590 600 610 620 630
pF1KSD YSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFV
520 530 540 550 560 570
640 650 660 670 680 690
pF1KSD TLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSR
580 590 600 610 620 630
700 710 720 730 740 750
pF1KSD KNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFL
640 650 660 670 680 690
760 770 780 790 800 810
pF1KSD GRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
700 710 720 730 740
>>XP_016874971 (OMIM: 609666) PREDICTED: two pore calciu (641 aa)
initn: 3737 init1: 3737 opt: 3737 Z-score: 3879.5 bits: 728.4 E(85289): 2.4e-209
Smith-Waterman score: 3737; 100.0% identity (100.0% similar) in 568 aa overlap (1-568:73-640)
10 20 30
pF1KSD MAVSLDDDVPLILTLDEGGSAPLAPSNGLG
::::::::::::::::::::::::::::::
XP_016 PWPSGFERELKPETISSPGYHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLG
50 60 70 80 90 100
40 50 60 70 80 90
pF1KSD QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH
110 120 130 140 150 160
100 110 120 130 140 150
pF1KSD PKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMV
170 180 190 200 210 220
160 170 180 190 200 210
pF1KSD VVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLV
230 240 250 260 270 280
220 230 240 250 260 270
pF1KSD DCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSI
290 300 310 320 330 340
280 290 300 310 320 330
pF1KSD VSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK
350 360 370 380 390 400
340 350 360 370 380 390
pF1KSD FKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNN
410 420 430 440 450 460
400 410 420 430 440 450
pF1KSD TPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLV
470 480 490 500 510 520
460 470 480 490 500 510
pF1KSD VAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLF
530 540 550 560 570 580
520 530 540 550 560 570
pF1KSD DFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMAR
590 600 610 620 630 640
580 590 600 610 620 630
pF1KSD GLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNF
>>XP_016874969 (OMIM: 609666) PREDICTED: two pore calciu (870 aa)
initn: 3064 init1: 3064 opt: 3075 Z-score: 3190.7 bits: 601.4 E(85289): 5.6e-171
Smith-Waterman score: 5171; 97.7% identity (97.8% similar) in 816 aa overlap (1-816:73-870)
10 20 30
pF1KSD MAVSLDDDVPLILTLDEGGSAPLAPSNGLG
::::::::::::::::::::::::::::::
XP_016 PWPSGFERELKPETISSPGYHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLG
50 60 70 80 90 100
40 50 60 70 80 90
pF1KSD QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH
110 120 130 140 150 160
100 110 120 130 140 150
pF1KSD PKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMV
170 180 190 200 210 220
160 170 180 190 200 210
pF1KSD VVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLV
230 240 250 260 270 280
220 230 240 250 260 270
pF1KSD DCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSI
290 300 310 320 330 340
280 290 300 310 320 330
pF1KSD VSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK
350 360 370 380 390 400
340 350 360 370 380 390
pF1KSD FKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNN
410 420 430 440 450 460
400 410 420 430 440 450
pF1KSD TPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLV
470 480 490 500 510 520
460 470 480 490 500 510
pF1KSD VAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLF
:::::::::::::::: .:::::::::::::::::::::::::
XP_016 VAVNGVWILVETFMLK------------------VYGVELFLKVAGLGPVEYLSSGWNLF
530 540 550 560
520 530 540 550 560 570
pF1KSD DFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASL
570 580 590 600 610 620
580 590 600 610 620 630
pF1KSD GLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNF
630 640 650 660 670 680
640 650 660 670 680 690
pF1KSD DNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAF
690 700 710 720 730 740
700 710 720 730 740 750
pF1KSD VFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERY
750 760 770 780 790 800
760 770 780 790 800 810
pF1KSD QQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQ
810 820 830 840 850 860
pF1KSD RSQTVT
::::::
XP_016 RSQTVT
870
816 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 05:12:18 2016 done: Thu Nov 3 05:12:20 2016
Total Scan time: 12.990 Total Display time: 0.280
Function used was FASTA [36.3.4 Apr, 2011]