FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1194, 557 aa 1>>>pF1KSDA1194 557 - 557 aa - 557 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5274+/-0.000507; mu= 17.2094+/- 0.031 mean_var=107.8243+/-24.082, 0's: 0 Z-trim(111.3): 249 B-trim: 896 in 1/48 Lambda= 0.123514 statistics sampled from 19486 (19837) to 19486 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.233), width: 16 Scan time: 10.240 The best scores are: opt bits E(85289) XP_011532908 (OMIM: 608951) PREDICTED: CCR4-NOT tr ( 557) 3712 673.3 5.3e-193 XP_005266010 (OMIM: 608951) PREDICTED: CCR4-NOT tr ( 557) 3712 673.3 5.3e-193 XP_011532909 (OMIM: 608951) PREDICTED: CCR4-NOT tr ( 557) 3712 673.3 5.3e-193 NP_001290170 (OMIM: 608951) CCR4-NOT transcription ( 557) 3712 673.3 5.3e-193 XP_011532907 (OMIM: 608951) PREDICTED: CCR4-NOT tr ( 552) 3660 664.1 3.3e-190 XP_016865159 (OMIM: 608951) PREDICTED: CCR4-NOT tr ( 462) 3097 563.7 4.6e-160 XP_016865160 (OMIM: 608951) PREDICTED: CCR4-NOT tr ( 462) 3097 563.7 4.6e-160 XP_016865161 (OMIM: 608951) PREDICTED: CCR4-NOT tr ( 428) 2763 504.1 3.6e-142 NP_689937 (OMIM: 179555) ras suppressor protein 1 ( 224) 238 53.9 6.4e-07 NP_036557 (OMIM: 179555) ras suppressor protein 1 ( 277) 238 54.0 7.4e-07 NP_036250 (OMIM: 608468) nocturnin [Homo sapiens] ( 431) 233 53.3 1.9e-06 NP_060979 (OMIM: 614854) leucine-rich repeat-conta ( 307) 225 51.7 4e-06 XP_016866486 (OMIM: 608195) PREDICTED: leucine-ric ( 331) 225 51.7 4.2e-06 XP_011513029 (OMIM: 608195) PREDICTED: leucine-ric ( 465) 225 51.9 5.3e-06 XP_011513028 (OMIM: 608195) PREDICTED: leucine-ric ( 524) 225 52.0 5.7e-06 NP_060684 (OMIM: 608195) leucine-rich repeat-conta ( 524) 225 52.0 5.7e-06 NP_062540 (OMIM: 608360,613506) volume-regulated a ( 810) 219 51.1 1.6e-05 XP_006717249 (OMIM: 608360,613506) PREDICTED: volu ( 810) 219 51.1 1.6e-05 XP_011517167 (OMIM: 608360,613506) PREDICTED: volu ( 810) 219 51.1 1.6e-05 NP_001120717 (OMIM: 608360,613506) volume-regulate ( 810) 219 51.1 1.6e-05 XP_011517165 (OMIM: 608360,613506) PREDICTED: volu ( 810) 219 51.1 1.6e-05 XP_011517166 (OMIM: 608360,613506) PREDICTED: volu ( 810) 219 51.1 1.6e-05 XP_005252153 (OMIM: 608360,613506) PREDICTED: volu ( 810) 219 51.1 1.6e-05 XP_005252152 (OMIM: 608360,613506) PREDICTED: volu ( 810) 219 51.1 1.6e-05 NP_001120716 (OMIM: 608360,613506) volume-regulate ( 810) 219 51.1 1.6e-05 XP_016857091 (OMIM: 612890) PREDICTED: volume-regu ( 858) 215 50.4 2.8e-05 NP_060573 (OMIM: 612890) volume-regulated anion ch ( 858) 215 50.4 2.8e-05 XP_016857088 (OMIM: 612890) PREDICTED: volume-regu ( 858) 215 50.4 2.8e-05 XP_016857090 (OMIM: 612890) PREDICTED: volume-regu ( 858) 215 50.4 2.8e-05 XP_011539991 (OMIM: 612890) PREDICTED: volume-regu ( 858) 215 50.4 2.8e-05 NP_001127951 (OMIM: 612890) volume-regulated anion ( 858) 215 50.4 2.8e-05 XP_016857089 (OMIM: 612890) PREDICTED: volume-regu ( 858) 215 50.4 2.8e-05 NP_056171 (OMIM: 607733) protein scribble homolog (1630) 217 51.0 3.3e-05 NP_874365 (OMIM: 607733) protein scribble homolog (1655) 217 51.1 3.4e-05 XP_005252609 (OMIM: 179555) PREDICTED: ras suppres ( 277) 206 48.3 3.9e-05 XP_016862666 (OMIM: 607180) PREDICTED: leucine-ric ( 258) 205 48.1 4.2e-05 XP_011532412 (OMIM: 607180) PREDICTED: leucine-ric ( 371) 205 48.2 5.3e-05 NP_078788 (OMIM: 607180) leucine-rich repeat-conta ( 371) 205 48.2 5.3e-05 NP_001275932 (OMIM: 611066) PH domain leucine-rich (1256) 210 49.7 6.6e-05 NP_055835 (OMIM: 611066) PH domain leucine-rich re (1323) 210 49.7 6.9e-05 NP_001255968 (OMIM: 602775,607721) leucine-rich re ( 536) 204 48.2 7.8e-05 XP_016872192 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 204 48.3 8.2e-05 XP_016872191 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 204 48.3 8.2e-05 NP_001311266 (OMIM: 602775,607721) leucine-rich re ( 582) 204 48.3 8.2e-05 NP_031399 (OMIM: 602775,607721) leucine-rich repea ( 582) 204 48.3 8.2e-05 XP_016872193 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 204 48.3 8.2e-05 NP_001311265 (OMIM: 602775,607721) leucine-rich re ( 582) 204 48.3 8.2e-05 XP_006717379 (OMIM: 610933,614436) PREDICTED: E3 u ( 690) 201 47.8 0.00013 NP_001177652 (OMIM: 610933,614436) E3 ubiquitin-pr ( 696) 201 47.8 0.00013 NP_612370 (OMIM: 610933,614436) E3 ubiquitin-prote ( 723) 201 47.8 0.00014 >>XP_011532908 (OMIM: 608951) PREDICTED: CCR4-NOT transc (557 aa) initn: 3712 init1: 3712 opt: 3712 Z-score: 3585.9 bits: 673.3 E(85289): 5.3e-193 Smith-Waterman score: 3712; 100.0% identity (100.0% similar) in 557 aa overlap (1-557:1-557) 10 20 30 40 50 60 pF1KSD MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL 490 500 510 520 530 540 550 pF1KSD LLPFLPQVNGIHLPGRR ::::::::::::::::: XP_011 LLPFLPQVNGIHLPGRR 550 >>XP_005266010 (OMIM: 608951) PREDICTED: CCR4-NOT transc (557 aa) initn: 3712 init1: 3712 opt: 3712 Z-score: 3585.9 bits: 673.3 E(85289): 5.3e-193 Smith-Waterman score: 3712; 100.0% identity (100.0% similar) in 557 aa overlap (1-557:1-557) 10 20 30 40 50 60 pF1KSD MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL 490 500 510 520 530 540 550 pF1KSD LLPFLPQVNGIHLPGRR ::::::::::::::::: XP_005 LLPFLPQVNGIHLPGRR 550 >>XP_011532909 (OMIM: 608951) PREDICTED: CCR4-NOT transc (557 aa) initn: 3712 init1: 3712 opt: 3712 Z-score: 3585.9 bits: 673.3 E(85289): 5.3e-193 Smith-Waterman score: 3712; 100.0% identity (100.0% similar) in 557 aa overlap (1-557:1-557) 10 20 30 40 50 60 pF1KSD MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL 490 500 510 520 530 540 550 pF1KSD LLPFLPQVNGIHLPGRR ::::::::::::::::: XP_011 LLPFLPQVNGIHLPGRR 550 >>NP_001290170 (OMIM: 608951) CCR4-NOT transcription com (557 aa) initn: 3712 init1: 3712 opt: 3712 Z-score: 3585.9 bits: 673.3 E(85289): 5.3e-193 Smith-Waterman score: 3712; 100.0% identity (100.0% similar) in 557 aa overlap (1-557:1-557) 10 20 30 40 50 60 pF1KSD MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL 490 500 510 520 530 540 550 pF1KSD LLPFLPQVNGIHLPGRR ::::::::::::::::: NP_001 LLPFLPQVNGIHLPGRR 550 >>XP_011532907 (OMIM: 608951) PREDICTED: CCR4-NOT transc (552 aa) initn: 2757 init1: 2660 opt: 3660 Z-score: 3535.9 bits: 664.1 E(85289): 3.3e-190 Smith-Waterman score: 3660; 98.9% identity (99.1% similar) in 557 aa overlap (1-557:1-552) 10 20 30 40 50 60 pF1KSD MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP :::::::::::::::::::::::::::::::::::::: .:::::::::::::::: XP_011 QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLS-----VTTEQPPPRSWIMLQEP 130 140 150 160 170 190 200 210 220 230 240 pF1KSD DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE 180 190 200 210 220 230 250 260 270 280 290 300 pF1KSD VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV 240 250 260 270 280 290 310 320 330 340 350 360 pF1KSD EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA 300 310 320 330 340 350 370 380 390 400 410 420 pF1KSD HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG 360 370 380 390 400 410 430 440 450 460 470 480 pF1KSD VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT 420 430 440 450 460 470 490 500 510 520 530 540 pF1KSD NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL 480 490 500 510 520 530 550 pF1KSD LLPFLPQVNGIHLPGRR ::::::::::::::::: XP_011 LLPFLPQVNGIHLPGRR 540 550 >>XP_016865159 (OMIM: 608951) PREDICTED: CCR4-NOT transc (462 aa) initn: 3097 init1: 3097 opt: 3097 Z-score: 2994.7 bits: 563.7 E(85289): 4.6e-160 Smith-Waterman score: 3097; 100.0% identity (100.0% similar) in 462 aa overlap (96-557:1-462) 70 80 90 100 110 120 pF1KSD IPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTL :::::::::::::::::::::::::::::: XP_016 MVSLRELHLNNNLLRVLPFELGKLFQLQTL 10 20 30 130 140 150 160 170 180 pF1KSD GLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEPDRTRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEPDRTRP 40 50 60 70 80 90 190 200 210 220 230 240 pF1KSD TALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVETEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVETEQ 100 110 120 130 140 150 250 260 270 280 290 300 pF1KSD YYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQL 160 170 180 190 200 210 310 320 330 340 350 360 pF1KSD AMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANAHMHWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANAHMHWD 220 230 240 250 260 270 370 380 390 400 410 420 pF1KSD PEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSGVVEYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSGVVEYL 280 290 300 310 320 330 430 440 450 460 470 480 pF1KSD STGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYTNYTFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYTNYTFD 340 350 360 370 380 390 490 500 510 520 530 540 pF1KSD FKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLELLLPFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLELLLPFL 400 410 420 430 440 450 550 pF1KSD PQVNGIHLPGRR :::::::::::: XP_016 PQVNGIHLPGRR 460 >>XP_016865160 (OMIM: 608951) PREDICTED: CCR4-NOT transc (462 aa) initn: 3097 init1: 3097 opt: 3097 Z-score: 2994.7 bits: 563.7 E(85289): 4.6e-160 Smith-Waterman score: 3097; 100.0% identity (100.0% similar) in 462 aa overlap (96-557:1-462) 70 80 90 100 110 120 pF1KSD IPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTL :::::::::::::::::::::::::::::: XP_016 MVSLRELHLNNNLLRVLPFELGKLFQLQTL 10 20 30 130 140 150 160 170 180 pF1KSD GLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEPDRTRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEPDRTRP 40 50 60 70 80 90 190 200 210 220 230 240 pF1KSD TALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVETEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVETEQ 100 110 120 130 140 150 250 260 270 280 290 300 pF1KSD YYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQL 160 170 180 190 200 210 310 320 330 340 350 360 pF1KSD AMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANAHMHWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANAHMHWD 220 230 240 250 260 270 370 380 390 400 410 420 pF1KSD PEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSGVVEYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSGVVEYL 280 290 300 310 320 330 430 440 450 460 470 480 pF1KSD STGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYTNYTFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYTNYTFD 340 350 360 370 380 390 490 500 510 520 530 540 pF1KSD FKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLELLLPFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLELLLPFL 400 410 420 430 440 450 550 pF1KSD PQVNGIHLPGRR :::::::::::: XP_016 PQVNGIHLPGRR 460 >>XP_016865161 (OMIM: 608951) PREDICTED: CCR4-NOT transc (428 aa) initn: 2763 init1: 2763 opt: 2763 Z-score: 2673.4 bits: 504.1 E(85289): 3.6e-142 Smith-Waterman score: 2763; 100.0% identity (100.0% similar) in 420 aa overlap (1-420:1-420) 10 20 30 40 50 60 pF1KSD MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT XP_016 YNRLHFLF >>NP_689937 (OMIM: 179555) ras suppressor protein 1 isof (224 aa) initn: 323 init1: 219 opt: 238 Z-score: 245.2 bits: 53.9 E(85289): 6.4e-07 Smith-Waterman score: 238; 36.2% identity (68.1% similar) in 138 aa overlap (42-172:72-205) 20 30 40 50 60 70 pF1KSD RRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIA :: .... :: : ::.::::.. .: ::. NP_689 MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG 50 60 70 80 90 100 80 90 100 110 120 pF1KSD KLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKL---FQLQTLGLK :: .: :.: .: . ::: :.:....:.:::...: : ::: :::.: : :.. . NP_689 KLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAE 110 120 130 140 150 160 130 140 150 160 170 180 pF1KSD GNPLTQDILNLYQEPDGTRRLLNYLLDN----LSGTAKRITTEQPPPRSWIMLQEPDRTR .:: . : . .: :. ....:. .. : : ... .. ::. NP_689 NNPWVTPIADQFQL--GVSHVFEYIRSETYKYLYG--RHMQANPEPPKKNNDKSKKISRK 170 180 190 200 210 190 200 210 220 230 240 pF1KSD PTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVETE NP_689 PLAAKNR 220 >>NP_036557 (OMIM: 179555) ras suppressor protein 1 isof (277 aa) initn: 376 init1: 219 opt: 238 Z-score: 244.1 bits: 54.0 E(85289): 7.4e-07 Smith-Waterman score: 238; 36.2% identity (68.1% similar) in 138 aa overlap (42-172:125-258) 20 30 40 50 60 70 pF1KSD RRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIA :: .... :: : ::.::::.. .: ::. NP_036 MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG 100 110 120 130 140 150 80 90 100 110 120 pF1KSD KLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKL---FQLQTLGLK :: .: :.: .: . ::: :.:....:.:::...: : ::: :::.: : :.. . NP_036 KLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAE 160 170 180 190 200 210 130 140 150 160 170 180 pF1KSD GNPLTQDILNLYQEPDGTRRLLNYLLDN----LSGTAKRITTEQPPPRSWIMLQEPDRTR .:: . : . .: :. ....:. .. : : ... .. ::. NP_036 NNPWVTPIADQFQL--GVSHVFEYIRSETYKYLYG--RHMQANPEPPKKNNDKSKKISRK 220 230 240 250 260 270 190 200 210 220 230 240 pF1KSD PTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVETE NP_036 PLAAKNR >-- initn: 193 init1: 171 opt: 202 Z-score: 209.4 bits: 47.6 E(85289): 6.3e-05 Smith-Waterman score: 202; 38.2% identity (76.4% similar) in 89 aa overlap (47-135:36-124) 20 30 40 50 60 70 pF1KSD IMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSDNSLSRIPSDIAKLHNL :..:.:.: : :: :.:. .: .::.:.:: NP_036 KKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNL 10 20 30 40 50 60 80 90 100 110 120 130 pF1KSD VYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLFQLQTLGLKGNPLTQDI :.. .:.:. ::...... .:..:.:. : : .:: .:.: :..: : : :... NP_036 EVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENS 70 80 90 100 110 120 140 150 160 170 180 190 pF1KSD LNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEPDRTRPTALFSVMCYNV NP_036 LPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKEL 130 140 150 160 170 180 557 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 05:17:52 2016 done: Thu Nov 3 05:17:54 2016 Total Scan time: 10.240 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]