FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1225, 1371 aa 1>>>pF1KSDA1225 1371 - 1371 aa - 1371 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.0103+/-0.000553; mu= 0.0079+/- 0.034 mean_var=305.9581+/-69.698, 0's: 0 Z-trim(115.4): 244 B-trim: 1283 in 1/55 Lambda= 0.073324 statistics sampled from 25586 (25889) to 25586 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.304), width: 16 Scan time: 17.760 The best scores are: opt bits E(85289) NP_061165 (OMIM: 606944) erbin isoform 2 [Homo sap (1371) 9004 968.2 0 NP_001240630 (OMIM: 606944) erbin isoform 9 [Homo (1367) 8962 963.8 0 NP_001240627 (OMIM: 606944) erbin isoform 4 [Homo (1346) 8635 929.2 0 XP_005248611 (OMIM: 606944) PREDICTED: protein LAP (1460) 7925 854.1 0 XP_016865124 (OMIM: 606944) PREDICTED: protein LAP (1460) 7925 854.1 0 NP_001240626 (OMIM: 606944) erbin isoform 1 [Homo (1412) 7922 853.8 0 NP_001240628 (OMIM: 606944) erbin isoform 8 [Homo (1419) 7916 853.1 0 XP_006714723 (OMIM: 606944) PREDICTED: protein LAP (1246) 7914 852.9 0 NP_001006600 (OMIM: 606944) erbin isoform 7 [Homo (1302) 7913 852.8 0 XP_005248612 (OMIM: 606944) PREDICTED: protein LAP (1456) 7883 849.7 0 XP_016865125 (OMIM: 606944) PREDICTED: protein LAP (1415) 7874 848.7 0 XP_016865126 (OMIM: 606944) PREDICTED: protein LAP (1298) 7871 848.3 0 XP_016857384 (OMIM: 614453) PREDICTED: leucine-ric (1255) 2267 255.5 1.8e-66 XP_016857383 (OMIM: 614453) PREDICTED: leucine-ric (1438) 2267 255.6 2e-66 XP_016857382 (OMIM: 614453) PREDICTED: leucine-ric (1472) 2267 255.6 2e-66 XP_016857381 (OMIM: 614453) PREDICTED: leucine-ric (1490) 2267 255.6 2e-66 NP_001317564 (OMIM: 614453) leucine-rich repeat-co (1495) 2267 255.6 2e-66 XP_016857379 (OMIM: 614453) PREDICTED: leucine-ric (1528) 2267 255.6 2e-66 XP_016857378 (OMIM: 614453) PREDICTED: leucine-ric (1537) 2267 255.6 2e-66 NP_065845 (OMIM: 614453) leucine-rich repeat-conta (1537) 2267 255.6 2e-66 XP_016857377 (OMIM: 614453) PREDICTED: leucine-ric (1541) 2267 255.6 2.1e-66 XP_016857376 (OMIM: 614453) PREDICTED: leucine-ric (1547) 2267 255.6 2.1e-66 XP_016857374 (OMIM: 614453) PREDICTED: leucine-ric (1594) 2267 255.6 2.1e-66 XP_016857375 (OMIM: 614453) PREDICTED: leucine-ric (1594) 2267 255.6 2.1e-66 NP_056171 (OMIM: 607733) protein scribble homolog (1630) 1327 156.2 1.8e-36 NP_874365 (OMIM: 607733) protein scribble homolog (1655) 1327 156.2 1.9e-36 XP_011513028 (OMIM: 608195) PREDICTED: leucine-ric ( 524) 1256 148.2 1.5e-34 NP_060684 (OMIM: 608195) leucine-rich repeat-conta ( 524) 1256 148.2 1.5e-34 XP_011513029 (OMIM: 608195) PREDICTED: leucine-ric ( 465) 981 119.1 7.6e-26 XP_016866486 (OMIM: 608195) PREDICTED: leucine-ric ( 331) 937 114.3 1.5e-24 NP_001311265 (OMIM: 602775,607721) leucine-rich re ( 582) 502 68.5 1.6e-10 XP_016872193 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 502 68.5 1.6e-10 XP_016872192 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 502 68.5 1.6e-10 NP_031399 (OMIM: 602775,607721) leucine-rich repea ( 582) 502 68.5 1.6e-10 XP_016872191 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 502 68.5 1.6e-10 NP_001311266 (OMIM: 602775,607721) leucine-rich re ( 582) 502 68.5 1.6e-10 XP_011542154 (OMIM: 605352) PREDICTED: malignant f (1003) 503 68.8 2.2e-10 NP_004216 (OMIM: 605352) malignant fibrous histioc (1052) 503 68.9 2.3e-10 NP_001243193 (OMIM: 600362) protein flightless-1 h (1258) 401 58.1 4.7e-07 XP_005256615 (OMIM: 600362) PREDICTED: protein fli (1268) 401 58.1 4.7e-07 NP_002009 (OMIM: 600362) protein flightless-1 homo (1269) 401 58.1 4.7e-07 XP_005256613 (OMIM: 600362) PREDICTED: protein fli (1295) 401 58.1 4.8e-07 XP_005256612 (OMIM: 600362) PREDICTED: protein fli (1296) 401 58.1 4.8e-07 NP_001243194 (OMIM: 600362) protein flightless-1 h (1214) 389 56.8 1.1e-06 NP_003658 (OMIM: 606667) leucine-rich repeat-conta ( 907) 376 55.4 2.3e-06 XP_016857088 (OMIM: 612890) PREDICTED: volume-regu ( 858) 368 54.5 4e-06 NP_001127951 (OMIM: 612890) volume-regulated anion ( 858) 368 54.5 4e-06 NP_060573 (OMIM: 612890) volume-regulated anion ch ( 858) 368 54.5 4e-06 XP_016857091 (OMIM: 612890) PREDICTED: volume-regu ( 858) 368 54.5 4e-06 XP_016857090 (OMIM: 612890) PREDICTED: volume-regu ( 858) 368 54.5 4e-06 >>NP_061165 (OMIM: 606944) erbin isoform 2 [Homo sapiens (1371 aa) initn: 9004 init1: 9004 opt: 9004 Z-score: 5165.5 bits: 968.2 E(85289): 0 Smith-Waterman score: 9004; 100.0% identity (100.0% similar) in 1371 aa overlap (1-1371:1-1371) 10 20 30 40 50 60 pF1KSD MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD LRHIEAKKLEKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 LRHIEAKKLEKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQ 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KSD PPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 PPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQP 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 pF1KSD EGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 EGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS 1330 1340 1350 1360 1370 >>NP_001240630 (OMIM: 606944) erbin isoform 9 [Homo sapi (1367 aa) initn: 5545 init1: 5545 opt: 8962 Z-score: 5141.6 bits: 963.8 E(85289): 0 Smith-Waterman score: 8962; 99.7% identity (99.7% similar) in 1371 aa overlap (1-1371:1-1367) 10 20 30 40 50 60 pF1KSD MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT :::::::::::::::::::::::::::::::::::::::::::::::::: :::::: NP_001 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKD----TSESTT 490 500 510 520 530 550 560 570 580 590 600 pF1KSD TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 540 550 560 570 580 590 610 620 630 640 650 660 pF1KSD LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 600 610 620 630 640 650 670 680 690 700 710 720 pF1KSD PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 660 670 680 690 700 710 730 740 750 760 770 780 pF1KSD KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 720 730 740 750 760 770 790 800 810 820 830 840 pF1KSD MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 780 790 800 810 820 830 850 860 870 880 890 900 pF1KSD SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 840 850 860 870 880 890 910 920 930 940 950 960 pF1KSD ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KSD PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KSD YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KSD SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KSD RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KSD LRHIEAKKLEKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRHIEAKKLEKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQ 1200 1210 1220 1230 1240 1250 1270 1280 1290 1300 1310 1320 pF1KSD PPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQP 1260 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 pF1KSD EGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS 1320 1330 1340 1350 1360 >>NP_001240627 (OMIM: 606944) erbin isoform 4 [Homo sapi (1346 aa) initn: 8824 init1: 8627 opt: 8635 Z-score: 4954.7 bits: 929.2 E(85289): 0 Smith-Waterman score: 8778; 98.2% identity (98.2% similar) in 1371 aa overlap (1-1371:1-1346) 10 20 30 40 50 60 pF1KSD MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD LRHIEAKKLEKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRHIEAKKLEKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQ 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KSD PPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQP ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDD--------- 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 pF1KSD EGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS ::::::::::::::::::::::::::::::::::: NP_001 ----------------ANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS 1320 1330 1340 >>XP_005248611 (OMIM: 606944) PREDICTED: protein LAP2 is (1460 aa) initn: 7916 init1: 7916 opt: 7925 Z-score: 4548.3 bits: 854.1 E(85289): 0 Smith-Waterman score: 8460; 93.7% identity (93.7% similar) in 1403 aa overlap (1-1314:1-1403) 10 20 30 40 50 60 pF1KSD MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1150 1160 1170 1180 1190 1200 1210 pF1KSD LRHIEAKKLEK------------------------------------------------- ::::::::::: XP_005 LRHIEAKKLEKSMLSRSFNSNFTTVSSFHCGSSRDLHGSQGSLALSVADRRGSGGHIFRK 1210 1220 1230 1240 1250 1260 1220 1230 pF1KSD ----------------------------------------MPLSNGQMGQPLRPQANYSQ :::::::::::::::::::: XP_005 HPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMKMPLSNGQMGQPLRPQANYSQ 1270 1280 1290 1300 1310 1320 1240 1250 1260 1270 1280 1290 pF1KSD IHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPEL 1330 1340 1350 1360 1370 1380 1300 1310 1320 1330 1340 1350 pF1KSD GFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAV ::::::::::::::::::::::: XP_005 GFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAV 1390 1400 1410 1420 1430 1440 >-- initn: 356 init1: 356 opt: 356 Z-score: 221.1 bits: 53.4 E(85289): 1.4e-05 Smith-Waterman score: 356; 100.0% identity (100.0% similar) in 57 aa overlap (1315-1371:1404-1460) 1290 1300 1310 1320 1330 1340 pF1KSD VEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFIN :::::::::::::::::::::::::::::: XP_005 VEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFIN 1380 1390 1400 1410 1420 1430 1350 1360 1370 pF1KSD IEHGQAVSLLKTFQNTVELIIVREVSS ::::::::::::::::::::::::::: XP_005 IEHGQAVSLLKTFQNTVELIIVREVSS 1440 1450 1460 >>XP_016865124 (OMIM: 606944) PREDICTED: protein LAP2 is (1460 aa) initn: 7916 init1: 7916 opt: 7925 Z-score: 4548.3 bits: 854.1 E(85289): 0 Smith-Waterman score: 8460; 93.7% identity (93.7% similar) in 1403 aa overlap (1-1314:1-1403) 10 20 30 40 50 60 pF1KSD MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1150 1160 1170 1180 1190 1200 1210 pF1KSD LRHIEAKKLEK------------------------------------------------- ::::::::::: XP_016 LRHIEAKKLEKSMLSRSFNSNFTTVSSFHCGSSRDLHGSQGSLALSVADRRGSGGHIFRK 1210 1220 1230 1240 1250 1260 1220 1230 pF1KSD ----------------------------------------MPLSNGQMGQPLRPQANYSQ :::::::::::::::::::: XP_016 HPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMKMPLSNGQMGQPLRPQANYSQ 1270 1280 1290 1300 1310 1320 1240 1250 1260 1270 1280 1290 pF1KSD IHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPEL 1330 1340 1350 1360 1370 1380 1300 1310 1320 1330 1340 1350 pF1KSD GFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAV ::::::::::::::::::::::: XP_016 GFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAV 1390 1400 1410 1420 1430 1440 >-- initn: 356 init1: 356 opt: 356 Z-score: 221.1 bits: 53.4 E(85289): 1.4e-05 Smith-Waterman score: 356; 100.0% identity (100.0% similar) in 57 aa overlap (1315-1371:1404-1460) 1290 1300 1310 1320 1330 1340 pF1KSD VEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFIN :::::::::::::::::::::::::::::: XP_016 VEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFIN 1380 1390 1400 1410 1420 1430 1350 1360 1370 pF1KSD IEHGQAVSLLKTFQNTVELIIVREVSS ::::::::::::::::::::::::::: XP_016 IEHGQAVSLLKTFQNTVELIIVREVSS 1440 1450 1460 >>NP_001240626 (OMIM: 606944) erbin isoform 1 [Homo sapi (1412 aa) initn: 7911 init1: 7911 opt: 7922 Z-score: 4546.8 bits: 853.8 E(85289): 0 Smith-Waterman score: 8864; 97.1% identity (97.1% similar) in 1403 aa overlap (1-1362:1-1403) 10 20 30 40 50 60 pF1KSD MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1150 1160 1170 1180 1190 1200 1210 pF1KSD LRHIEAKKLEK-----------------------------------------MPLSNGQM ::::::::::: :::::::: NP_001 LRHIEAKKLEKKHPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMKMPLSNGQM 1210 1220 1230 1240 1250 1260 1220 1230 1240 1250 1260 1270 pF1KSD GQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQ 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KSD EIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANG 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 pF1KSD YSFINIEHGQAVSLLKTFQNTVELIIVREVSS ::::::::::::::::::::::: NP_001 YSFINIEHGQAVSLLKTFQNTVELIIVREVSS 1390 1400 1410 >>NP_001240628 (OMIM: 606944) erbin isoform 8 [Homo sapi (1419 aa) initn: 7916 init1: 7916 opt: 7916 Z-score: 4543.3 bits: 853.1 E(85289): 0 Smith-Waterman score: 8807; 96.6% identity (96.6% similar) in 1403 aa overlap (1-1355:1-1403) 10 20 30 40 50 60 pF1KSD MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1150 1160 1170 1180 1190 1200 1210 pF1KSD LRHIEAKKLEK------------------------------------------------M ::::::::::: : NP_001 LRHIEAKKLEKSMLSRSFNSNFTTVSSFHCGSSRDLHGSQGSLALSVADRRGSGGHIFRM 1210 1220 1230 1240 1250 1260 1220 1230 1240 1250 1260 1270 pF1KSD PLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQ 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KSD GHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGD 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 pF1KSD KIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS ::::::::::::::::::::::: NP_001 KIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS 1390 1400 1410 >>XP_006714723 (OMIM: 606944) PREDICTED: protein LAP2 is (1246 aa) initn: 8646 init1: 7914 opt: 7914 Z-score: 4542.9 bits: 852.9 E(85289): 0 Smith-Waterman score: 7914; 99.8% identity (99.9% similar) in 1215 aa overlap (1-1215:1-1215) 10 20 30 40 50 60 pF1KSD MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD LRHIEAKKLEKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQ :::::::::::. .: XP_006 LRHIEAKKLEKVFFSGTGNRVPNLNSARTIGMIMCVSILSFTPHCF 1210 1220 1230 1240 >>NP_001006600 (OMIM: 606944) erbin isoform 7 [Homo sapi (1302 aa) initn: 7913 init1: 7913 opt: 7913 Z-score: 4542.1 bits: 852.8 E(85289): 0 Smith-Waterman score: 8359; 95.0% identity (95.0% similar) in 1371 aa overlap (1-1371:1-1302) 10 20 30 40 50 60 pF1KSD MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD LRHIEAKKLEKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQ ::::::::::: NP_001 LRHIEAKKLEK------------------------------------------------- 1210 1270 1280 1290 1300 1310 1320 pF1KSD PPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQP :::::::::::::::::::::::::::::::::::::::: NP_001 --------------------IRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQP 1220 1230 1240 1250 1330 1340 1350 1360 1370 pF1KSD EGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS 1260 1270 1280 1290 1300 >>XP_005248612 (OMIM: 606944) PREDICTED: protein LAP2 is (1456 aa) initn: 4564 init1: 4457 opt: 7883 Z-score: 4524.3 bits: 849.7 E(85289): 0 Smith-Waterman score: 8418; 93.4% identity (93.4% similar) in 1403 aa overlap (1-1314:1-1399) 10 20 30 40 50 60 pF1KSD MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT :::::::::::::::::::::::::::::::::::::::::::::::::: :::::: XP_005 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKD----TSESTT 490 500 510 520 530 550 560 570 580 590 600 pF1KSD TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 540 550 560 570 580 590 610 620 630 640 650 660 pF1KSD LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 600 610 620 630 640 650 670 680 690 700 710 720 pF1KSD PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 660 670 680 690 700 710 730 740 750 760 770 780 pF1KSD KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 720 730 740 750 760 770 790 800 810 820 830 840 pF1KSD MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 780 790 800 810 820 830 850 860 870 880 890 900 pF1KSD SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 840 850 860 870 880 890 910 920 930 940 950 960 pF1KSD ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KSD PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KSD YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KSD SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KSD RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1140 1150 1160 1170 1180 1190 1210 pF1KSD LRHIEAKKLEK------------------------------------------------- ::::::::::: XP_005 LRHIEAKKLEKSMLSRSFNSNFTTVSSFHCGSSRDLHGSQGSLALSVADRRGSGGHIFRK 1200 1210 1220 1230 1240 1250 1220 1230 pF1KSD ----------------------------------------MPLSNGQMGQPLRPQANYSQ :::::::::::::::::::: XP_005 HPQTSSSGDPCQDGIFISGQQNYSSATLSHKDVPPDSLMKMPLSNGQMGQPLRPQANYSQ 1260 1270 1280 1290 1300 1310 1240 1250 1260 1270 1280 1290 pF1KSD IHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPEL 1320 1330 1340 1350 1360 1370 1300 1310 1320 1330 1340 1350 pF1KSD GFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAV ::::::::::::::::::::::: XP_005 GFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAV 1380 1390 1400 1410 1420 1430 >-- initn: 356 init1: 356 opt: 356 Z-score: 221.1 bits: 53.4 E(85289): 1.4e-05 Smith-Waterman score: 356; 100.0% identity (100.0% similar) in 57 aa overlap (1315-1371:1400-1456) 1290 1300 1310 1320 1330 1340 pF1KSD VEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFIN :::::::::::::::::::::::::::::: XP_005 VEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFIN 1370 1380 1390 1400 1410 1420 1350 1360 1370 pF1KSD IEHGQAVSLLKTFQNTVELIIVREVSS ::::::::::::::::::::::::::: XP_005 IEHGQAVSLLKTFQNTVELIIVREVSS 1430 1440 1450 1371 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 05:27:15 2016 done: Thu Nov 3 05:27:18 2016 Total Scan time: 17.760 Total Display time: 0.800 Function used was FASTA [36.3.4 Apr, 2011]