FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1242, 493 aa 1>>>pF1KSDA1242 493 - 493 aa - 493 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0217+/-0.000492; mu= 10.0641+/- 0.030 mean_var=168.1969+/-36.120, 0's: 0 Z-trim(114.3): 292 B-trim: 2116 in 2/48 Lambda= 0.098893 statistics sampled from 23635 (24082) to 23635 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.282), width: 16 Scan time: 10.290 The best scores are: opt bits E(85289) NP_057347 (OMIM: 603619) fizzy-related protein hom ( 493) 3300 483.7 5e-136 XP_005259630 (OMIM: 603619) PREDICTED: fizzy-relat ( 496) 3284 481.4 2.5e-135 NP_001129670 (OMIM: 603619) fizzy-related protein ( 496) 3284 481.4 2.5e-135 XP_016882352 (OMIM: 603619) PREDICTED: fizzy-relat ( 528) 3284 481.5 2.6e-135 NP_001129669 (OMIM: 603619) fizzy-related protein ( 404) 1856 277.6 4.6e-74 NP_001246 (OMIM: 603618) cell division cycle prote ( 499) 1094 169.0 2.8e-41 XP_016878353 (OMIM: 602703,616212) PREDICTED: kata ( 655) 320 58.7 6e-08 XP_016878352 (OMIM: 602703,616212) PREDICTED: kata ( 655) 320 58.7 6e-08 NP_005877 (OMIM: 602703,616212) katanin p80 WD40 r ( 655) 320 58.7 6e-08 XP_006721186 (OMIM: 602703,616212) PREDICTED: kata ( 658) 320 58.7 6e-08 XP_016878351 (OMIM: 602703,616212) PREDICTED: kata ( 672) 320 58.7 6.1e-08 XP_005255829 (OMIM: 602703,616212) PREDICTED: kata ( 672) 320 58.7 6.1e-08 XP_016878350 (OMIM: 602703,616212) PREDICTED: kata ( 672) 320 58.7 6.1e-08 XP_016878349 (OMIM: 602703,616212) PREDICTED: kata ( 675) 320 58.7 6.1e-08 XP_006721184 (OMIM: 602703,616212) PREDICTED: kata ( 675) 320 58.7 6.1e-08 XP_011521112 (OMIM: 602703,616212) PREDICTED: kata ( 675) 320 58.7 6.1e-08 XP_006721185 (OMIM: 602703,616212) PREDICTED: kata ( 675) 320 58.7 6.1e-08 XP_005247749 (OMIM: 610863,615185) PREDICTED: guan ( 340) 267 50.8 7.1e-06 NP_067642 (OMIM: 610863,615185) guanine nucleotide ( 340) 267 50.8 7.1e-06 XP_006713784 (OMIM: 610863,615185) PREDICTED: guan ( 340) 267 50.8 7.1e-06 NP_001308124 (OMIM: 270710,602342,608628,616944) F ( 427) 262 50.2 1.4e-05 XP_006713809 (OMIM: 270710,602342,608628,616944) P ( 514) 262 50.3 1.6e-05 NP_001308123 (OMIM: 270710,602342,608628,616944) F ( 514) 262 50.3 1.6e-05 XP_011511444 (OMIM: 270710,602342,608628,616944) P ( 514) 262 50.3 1.6e-05 XP_005247832 (OMIM: 270710,602342,608628,616944) P ( 514) 262 50.3 1.6e-05 NP_001308122 (OMIM: 270710,602342,608628,616944) F ( 514) 262 50.3 1.6e-05 XP_011511445 (OMIM: 270710,602342,608628,616944) P ( 514) 262 50.3 1.6e-05 XP_016862674 (OMIM: 270710,602342,608628,616944) P ( 514) 262 50.3 1.6e-05 NP_078941 (OMIM: 270710,602342,608628,616944) F-bo ( 514) 262 50.3 1.6e-05 XP_011511443 (OMIM: 270710,602342,608628,616944) P ( 514) 262 50.3 1.6e-05 XP_016885575 (OMIM: 400033) PREDICTED: F-box-like/ ( 577) 261 50.2 1.9e-05 NP_060058 (OMIM: 609012) WD repeat-containing prot ( 334) 257 49.4 1.9e-05 NP_438172 (OMIM: 609012) WD repeat-containing prot ( 334) 257 49.4 1.9e-05 XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-c ( 334) 257 49.4 1.9e-05 XP_005267076 (OMIM: 215100,266500,601757,614879) P ( 285) 255 49.0 2.1e-05 NP_001284500 (OMIM: 139130,145500,617024) guanine ( 339) 256 49.3 2.1e-05 NP_002066 (OMIM: 139130,145500,617024) guanine nuc ( 340) 256 49.3 2.1e-05 XP_016856550 (OMIM: 139380,613065,616973) PREDICTE ( 340) 256 49.3 2.1e-05 XP_016856548 (OMIM: 139380,613065,616973) PREDICTE ( 340) 256 49.3 2.1e-05 NP_002065 (OMIM: 139380,613065,616973) guanine nuc ( 340) 256 49.3 2.1e-05 NP_001269468 (OMIM: 139380,613065,616973) guanine ( 340) 256 49.3 2.1e-05 XP_016856549 (OMIM: 139380,613065,616973) PREDICTE ( 340) 256 49.3 2.1e-05 XP_016885576 (OMIM: 400033) PREDICTED: F-box-like/ ( 540) 259 49.9 2.2e-05 NP_000279 (OMIM: 215100,266500,601757,614879) pero ( 323) 255 49.1 2.3e-05 NP_001269467 (OMIM: 139380,613065,616973) guanine ( 240) 247 47.8 4.1e-05 NP_599021 (OMIM: 400033) F-box-like/WD repeat-cont ( 522) 252 48.9 4.2e-05 NP_599020 (OMIM: 400033) F-box-like/WD repeat-cont ( 522) 252 48.9 4.2e-05 NP_150600 (OMIM: 400033) F-box-like/WD repeat-cont ( 522) 252 48.9 4.2e-05 XP_005262629 (OMIM: 400033) PREDICTED: F-box-like/ ( 536) 252 48.9 4.3e-05 NP_005264 (OMIM: 139390) guanine nucleotide-bindin ( 340) 247 48.0 5.2e-05 >>NP_057347 (OMIM: 603619) fizzy-related protein homolog (493 aa) initn: 3300 init1: 3300 opt: 3300 Z-score: 2563.0 bits: 483.7 E(85289): 5e-136 Smith-Waterman score: 3300; 100.0% identity (100.0% similar) in 493 aa overlap (1-493:1-493) 10 20 30 40 50 60 pF1KSD MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD TPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 TPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD APELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 APELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSER 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK 430 440 450 460 470 480 490 pF1KSD ESVSVLNLFTRIR ::::::::::::: NP_057 ESVSVLNLFTRIR 490 >>XP_005259630 (OMIM: 603619) PREDICTED: fizzy-related p (496 aa) initn: 3286 init1: 3225 opt: 3284 Z-score: 2550.7 bits: 481.4 E(85289): 2.5e-135 Smith-Waterman score: 3284; 99.4% identity (99.4% similar) in 496 aa overlap (1-493:1-496) 10 20 30 40 50 60 pF1KSD MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD TPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD APELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 APELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSER 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK 430 440 450 460 470 480 490 pF1KSD ---ESVSVLNLFTRIR ::::::::::::: XP_005 VKWESVSVLNLFTRIR 490 >>NP_001129670 (OMIM: 603619) fizzy-related protein homo (496 aa) initn: 3286 init1: 3225 opt: 3284 Z-score: 2550.7 bits: 481.4 E(85289): 2.5e-135 Smith-Waterman score: 3284; 99.4% identity (99.4% similar) in 496 aa overlap (1-493:1-496) 10 20 30 40 50 60 pF1KSD MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD TPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD APELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSER 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK 430 440 450 460 470 480 490 pF1KSD ---ESVSVLNLFTRIR ::::::::::::: NP_001 VKWESVSVLNLFTRIR 490 >>XP_016882352 (OMIM: 603619) PREDICTED: fizzy-related p (528 aa) initn: 3286 init1: 3225 opt: 3284 Z-score: 2550.3 bits: 481.5 E(85289): 2.6e-135 Smith-Waterman score: 3284; 99.4% identity (99.4% similar) in 496 aa overlap (1-493:33-528) 10 20 30 pF1KSD MDQDYERRLLRQIVIQNENTMPRVTEMRRT :::::::::::::::::::::::::::::: XP_016 GSCSGVWRAALVRPSPVDALTLPRAEPCLAMDQDYERRLLRQIVIQNENTMPRVTEMRRT 10 20 30 40 50 60 40 50 60 70 80 90 pF1KSD LTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLA 70 80 90 100 110 120 100 110 120 130 140 150 pF1KSD YSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KSD SPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVY 190 200 210 220 230 240 220 230 240 250 260 270 pF1KSD LWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGH 250 260 270 280 290 300 280 290 300 310 320 330 pF1KSD TARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLAS 310 320 330 340 350 360 340 350 360 370 380 390 pF1KSD GGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTG 370 380 390 400 410 420 400 410 420 430 440 450 pF1KSD QPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLA 430 440 450 460 470 480 460 470 480 490 pF1KSD MSPDGEAIVTGAGDETLRFWNVFSKTRSTK---ESVSVLNLFTRIR :::::::::::::::::::::::::::::: ::::::::::::: XP_016 MSPDGEAIVTGAGDETLRFWNVFSKTRSTKVKWESVSVLNLFTRIR 490 500 510 520 >>NP_001129669 (OMIM: 603619) fizzy-related protein homo (404 aa) initn: 1856 init1: 1856 opt: 1856 Z-score: 1450.7 bits: 277.6 E(85289): 4.6e-74 Smith-Waterman score: 2518; 81.9% identity (81.9% similar) in 493 aa overlap (1-493:1-404) 10 20 30 40 50 60 pF1KSD MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHRINENEKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD TPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLD ::::::::: NP_001 TPEKKGLFT--------------------------------------------------- 190 200 210 220 230 240 pF1KSD APELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSER :::::::::::::::::::::: NP_001 --------------------------------------VTRLCDLSVEGDSVTSVGWSER 130 140 150 250 260 270 280 290 300 pF1KSD GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRT 160 170 180 190 200 210 310 320 330 340 350 360 pF1KSD PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA 220 230 240 250 260 270 370 380 390 400 410 420 pF1KSD IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGY 280 290 300 310 320 330 430 440 450 460 470 480 pF1KSD SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK 340 350 360 370 380 390 490 pF1KSD ESVSVLNLFTRIR ::::::::::::: NP_001 ESVSVLNLFTRIR 400 >>NP_001246 (OMIM: 603618) cell division cycle protein 2 (499 aa) initn: 1157 init1: 490 opt: 1094 Z-score: 862.0 bits: 169.0 E(85289): 2.8e-41 Smith-Waterman score: 1113; 41.3% identity (67.2% similar) in 458 aa overlap (29-473:58-473) 10 20 30 40 50 pF1KSD MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPV-SSPSKHG-DRFIPSRAGAN :: .:: : ..::: : ::.:: :..:. NP_001 WQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTPGKSSSKVQTTPSKPGGDRYIPHRSAAQ 30 40 50 60 70 80 60 70 80 90 100 pF1KSD WSVNFHRIN-----ENEKSPSQNRKAKD-ATSDNGKDGLAYSALLKNELLGAGIEKVQD- : .. :: ..:..... : : . :: : . . .:. : : : :. NP_001 MEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFD-VEEAKILR--LSG----KPQNA 90 100 110 120 130 140 110 120 130 140 150 160 pF1KSD PQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTR :. . ::. : .....: : :: : NP_001 PEGYQNRLK------------VLYSQKATPG----------------------SSRKTCR 150 160 170 180 190 200 210 220 pF1KSD KISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEG : ..: ..:::::...:.::::::::: :::.:.: . :::::: .... .: .. : NP_001 YIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPG 170 180 190 200 210 220 230 240 250 260 270 280 pF1KSD DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSR . ..::.: ..:: .:::: .. ::.::. :.: . .:.::::.:.::. :::::: NP_001 EYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSR 230 240 250 260 270 280 290 300 310 320 330 340 pF1KSD DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVW----NHSSL . : ..:.:. . :.:: ::::::.:. : . :::::::: . :: .... NP_001 SGHIHHHDVRVAE-HHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGW 290 300 310 320 330 340 350 360 370 380 390 400 pF1KSD SPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNL :.: .:.: .::::.:: : : ..::.::::.:: ::.::. .: :. .:. ::::.. NP_001 VPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSI 350 360 370 380 390 400 410 420 430 440 450 460 pF1KSD AWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDE :: : .::.: ::..:::...::::....::.: ::. ::: :.::::: .....:.:: NP_001 LWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADE 410 420 430 440 450 460 470 480 490 pF1KSD TLRFWNVFSKTRSTKESVSVLNLFTRIR :::.: : NP_001 TLRLWRCFELDPARRREREKASAAKSSLIHQGIR 470 480 490 >>XP_016878353 (OMIM: 602703,616212) PREDICTED: katanin (655 aa) initn: 283 init1: 137 opt: 320 Z-score: 263.7 bits: 58.7 E(85289): 6e-08 Smith-Waterman score: 320; 31.9% identity (60.9% similar) in 207 aa overlap (196-397:31-228) 170 180 190 200 210 220 pF1KSD KPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTC-VYLWSACTSQVTRLCD .: .:..: : : ::: . : XP_016 MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPN----CI 10 20 30 40 50 230 240 250 260 270 280 pF1KSD LSVEGDS--VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN-- .:. : . : :: . .:...:...: ...:: :.: : : :: : . .: .. XP_016 MSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPY 60 70 80 90 100 110 290 300 310 320 330 340 pF1KSD AEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVW .: ..:::.: : ::: : .:: : : :..: : . :::...:. . .: XP_016 GEFVASGSQDTNIKLWDIRRKG--CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLW 120 130 140 150 160 170 350 360 370 380 390 400 pF1KSD NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGS . .. . .... : . :... . :... ::::: ..:: ::::. : ..::. XP_016 DLTAGKMMSEFPGHTGPVNVVEFHPNEY-LLASG--SSDRTIRFWDLEKFQVVSCIEGEP 180 190 200 210 220 230 410 420 430 440 450 460 pF1KSD QVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVT XP_016 GPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFS 240 250 260 270 280 290 >>XP_016878352 (OMIM: 602703,616212) PREDICTED: katanin (655 aa) initn: 283 init1: 137 opt: 320 Z-score: 263.7 bits: 58.7 E(85289): 6e-08 Smith-Waterman score: 320; 31.9% identity (60.9% similar) in 207 aa overlap (196-397:31-228) 170 180 190 200 210 220 pF1KSD KPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTC-VYLWSACTSQVTRLCD .: .:..: : : ::: . : XP_016 MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPN----CI 10 20 30 40 50 230 240 250 260 270 280 pF1KSD LSVEGDS--VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN-- .:. : . : :: . .:...:...: ...:: :.: : : :: : . .: .. XP_016 MSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPY 60 70 80 90 100 110 290 300 310 320 330 340 pF1KSD AEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVW .: ..:::.: : ::: : .:: : : :..: : . :::...:. . .: XP_016 GEFVASGSQDTNIKLWDIRRKG--CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLW 120 130 140 150 160 170 350 360 370 380 390 400 pF1KSD NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGS . .. . .... : . :... . :... ::::: ..:: ::::. : ..::. XP_016 DLTAGKMMSEFPGHTGPVNVVEFHPNEY-LLASG--SSDRTIRFWDLEKFQVVSCIEGEP 180 190 200 210 220 230 410 420 430 440 450 460 pF1KSD QVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVT XP_016 GPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFS 240 250 260 270 280 290 >>NP_005877 (OMIM: 602703,616212) katanin p80 WD40 repea (655 aa) initn: 283 init1: 137 opt: 320 Z-score: 263.7 bits: 58.7 E(85289): 6e-08 Smith-Waterman score: 320; 31.9% identity (60.9% similar) in 207 aa overlap (196-397:31-228) 170 180 190 200 210 220 pF1KSD KPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTC-VYLWSACTSQVTRLCD .: .:..: : : ::: . : NP_005 MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPN----CI 10 20 30 40 50 230 240 250 260 270 280 pF1KSD LSVEGDS--VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN-- .:. : . : :: . .:...:...: ...:: :.: : : :: : . .: .. NP_005 MSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPY 60 70 80 90 100 110 290 300 310 320 330 340 pF1KSD AEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVW .: ..:::.: : ::: : .:: : : :..: : . :::...:. . .: NP_005 GEFVASGSQDTNIKLWDIRRKG--CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLW 120 130 140 150 160 170 350 360 370 380 390 400 pF1KSD NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGS . .. . .... : . :... . :... ::::: ..:: ::::. : ..::. NP_005 DLTAGKMMSEFPGHTGPVNVVEFHPNEY-LLASG--SSDRTIRFWDLEKFQVVSCIEGEP 180 190 200 210 220 230 410 420 430 440 450 460 pF1KSD QVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVT NP_005 GPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFS 240 250 260 270 280 290 >>XP_006721186 (OMIM: 602703,616212) PREDICTED: katanin (658 aa) initn: 283 init1: 137 opt: 320 Z-score: 263.7 bits: 58.7 E(85289): 6e-08 Smith-Waterman score: 320; 31.9% identity (60.9% similar) in 207 aa overlap (196-397:31-228) 170 180 190 200 210 220 pF1KSD KPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTC-VYLWSACTSQVTRLCD .: .:..: : : ::: . : XP_006 MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPN----CI 10 20 30 40 50 230 240 250 260 270 280 pF1KSD LSVEGDS--VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWN-- .:. : . : :: . .:...:...: ...:: :.: : : :: : . .: .. XP_006 MSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPY 60 70 80 90 100 110 290 300 310 320 330 340 pF1KSD AEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVW .: ..:::.: : ::: : .:: : : :..: : . :::...:. . .: XP_006 GEFVASGSQDTNIKLWDIRRKG--CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLW 120 130 140 150 160 170 350 360 370 380 390 400 pF1KSD NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGS . .. . .... : . :... . :... ::::: ..:: ::::. : ..::. XP_006 DLTAGKMMSEFPGHTGPVNVVEFHPNEY-LLASG--SSDRTIRFWDLEKFQVVSCIEGEP 180 190 200 210 220 230 410 420 430 440 450 460 pF1KSD QVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVT XP_006 GPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFS 240 250 260 270 280 290 493 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 05:30:38 2016 done: Thu Nov 3 05:30:40 2016 Total Scan time: 10.290 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]