FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1266, 537 aa 1>>>pF1KSDA1266 537 - 537 aa - 537 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0113+/-0.000365; mu= 15.0668+/- 0.023 mean_var=78.5846+/-15.576, 0's: 0 Z-trim(114.0): 103 B-trim: 397 in 1/54 Lambda= 0.144679 statistics sampled from 23533 (23644) to 23533 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.277), width: 16 Scan time: 10.260 The best scores are: opt bits E(85289) NP_001269685 (OMIM: 609050) metastasis-associated ( 537) 3596 760.4 0 NP_001269684 (OMIM: 609050) metastasis-associated ( 537) 3596 760.4 0 NP_001317372 (OMIM: 609050) metastasis-associated ( 593) 3596 760.4 0 XP_005264516 (OMIM: 609050) PREDICTED: metastasis- ( 538) 3584 757.9 1.8e-218 NP_001317371 (OMIM: 609050) metastasis-associated ( 594) 3584 757.9 1.9e-218 NP_065795 (OMIM: 609050) metastasis-associated pro ( 515) 3008 637.6 2.7e-182 NP_001317373 (OMIM: 609050) metastasis-associated ( 530) 2033 434.1 5e-121 XP_016877247 (OMIM: 603526) PREDICTED: metastasis- ( 726) 1997 426.7 1.2e-118 XP_011535612 (OMIM: 603526) PREDICTED: metastasis- ( 742) 1997 426.7 1.2e-118 XP_011535611 (OMIM: 603526) PREDICTED: metastasis- ( 754) 1997 426.7 1.2e-118 XP_011535610 (OMIM: 603526) PREDICTED: metastasis- ( 758) 1997 426.7 1.2e-118 XP_016877244 (OMIM: 603526) PREDICTED: metastasis- ( 782) 1997 426.7 1.3e-118 NP_004680 (OMIM: 603526) metastasis-associated pro ( 715) 1955 417.9 5.2e-116 XP_016877246 (OMIM: 603526) PREDICTED: metastasis- ( 743) 1955 417.9 5.3e-116 XP_011535609 (OMIM: 603526) PREDICTED: metastasis- ( 759) 1955 417.9 5.4e-116 XP_011535608 (OMIM: 603526) PREDICTED: metastasis- ( 771) 1955 417.9 5.5e-116 XP_016877245 (OMIM: 603526) PREDICTED: metastasis- ( 772) 1955 417.9 5.5e-116 XP_011535607 (OMIM: 603526) PREDICTED: metastasis- ( 775) 1955 417.9 5.5e-116 XP_016877243 (OMIM: 603526) PREDICTED: metastasis- ( 783) 1955 417.9 5.6e-116 XP_016877242 (OMIM: 603526) PREDICTED: metastasis- ( 795) 1955 417.9 5.7e-116 XP_016877241 (OMIM: 603526) PREDICTED: metastasis- ( 799) 1955 417.9 5.7e-116 XP_016877248 (OMIM: 603526) PREDICTED: metastasis- ( 657) 1928 412.3 2.4e-114 NP_004730 (OMIM: 603947) metastasis-associated pro ( 668) 1901 406.6 1.2e-112 XP_016860051 (OMIM: 609050) PREDICTED: metastasis- ( 341) 1853 396.5 7e-110 NP_001190187 (OMIM: 603526) metastasis-associated ( 430) 1659 356.0 1.3e-97 NP_001317221 (OMIM: 603947) metastasis-associated ( 495) 1370 295.7 2.1e-79 XP_011539813 (OMIM: 605226,616975) PREDICTED: argi (1181) 386 90.5 3.1e-17 XP_011539812 (OMIM: 605226,616975) PREDICTED: argi (1524) 386 90.6 3.8e-17 NP_036234 (OMIM: 605226,616975) arginine-glutamic (1566) 386 90.6 3.9e-17 XP_016856847 (OMIM: 605226,616975) PREDICTED: argi (1566) 386 90.6 3.9e-17 XP_016856848 (OMIM: 605226,616975) PREDICTED: argi (1566) 386 90.6 3.9e-17 NP_001036146 (OMIM: 605226,616975) arginine-glutam (1566) 386 90.6 3.9e-17 XP_005263521 (OMIM: 605226,616975) PREDICTED: argi (1566) 386 90.6 3.9e-17 XP_005263523 (OMIM: 605226,616975) PREDICTED: argi (1298) 317 76.1 7.2e-13 NP_055971 (OMIM: 607675) REST corepressor 1 [Homo ( 485) 176 46.5 0.00022 NP_001139585 (OMIM: 616848) mesoderm induction ear ( 370) 161 43.3 0.0015 NP_001071172 (OMIM: 616848) mesoderm induction ear ( 433) 161 43.4 0.0018 XP_016857421 (OMIM: 616848) PREDICTED: mesoderm in ( 449) 161 43.4 0.0018 XP_016857422 (OMIM: 616848) PREDICTED: mesoderm in ( 449) 161 43.4 0.0018 XP_016857423 (OMIM: 616848) PREDICTED: mesoderm in ( 449) 161 43.4 0.0018 NP_001071170 (OMIM: 616848) mesoderm induction ear ( 450) 161 43.4 0.0018 NP_001139583 (OMIM: 616848) mesoderm induction ear ( 470) 161 43.4 0.0019 XP_016857420 (OMIM: 616848) PREDICTED: mesoderm in ( 485) 161 43.4 0.0019 NP_001139584 (OMIM: 616848) mesoderm induction ear ( 485) 161 43.4 0.0019 NP_001071171 (OMIM: 616848) mesoderm induction ear ( 486) 161 43.4 0.002 XP_016857419 (OMIM: 616848) PREDICTED: mesoderm in ( 511) 161 43.4 0.002 XP_016857418 (OMIM: 616848) PREDICTED: mesoderm in ( 511) 161 43.4 0.002 XP_016857417 (OMIM: 616848) PREDICTED: mesoderm in ( 511) 161 43.4 0.002 XP_016857416 (OMIM: 616848) PREDICTED: mesoderm in ( 511) 161 43.4 0.002 NP_001071169 (OMIM: 616848) mesoderm induction ear ( 512) 161 43.4 0.002 >>NP_001269685 (OMIM: 609050) metastasis-associated prot (537 aa) initn: 3596 init1: 3596 opt: 3596 Z-score: 4056.9 bits: 760.4 E(85289): 0 Smith-Waterman score: 3596; 100.0% identity (100.0% similar) in 537 aa overlap (1-537:1-537) 10 20 30 40 50 60 pF1KSD MLADKHAKEIEEESETTVEADLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLADKHAKEIEEESETTVEADLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD TESVLSYLDKEDTFFYSLVYDPSLKTLLADKGEIRVGPRYQADIPEMLLEGESDEREQSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TESVLSYLDKEDTFFYSLVYDPSLKTLLADKGEIRVGPRYQADIPEMLLEGESDEREQSK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LEVKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEVKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD AMDTLYRHSYDLSSAISVLVPLGGPVLCRDEMEEWSASEASLFEEALEKYGKDFNDIRQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AMDTLYRHSYDLSSAISVLVPLGGPVLCRDEMEEWSASEASLFEEALEKYGKDFNDIRQD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD FLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYKPNPNQISTSNGKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYKPNPNQISTSNGKP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GAVNGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAVNGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGLK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD MPTQSEEEKLSPSPTTEDPRVRSHVSRQAMQGMPVRNTGSPKSAVKTRQAFFLHTTYFTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPTQSEEEKLSPSPTTEDPRVRSHVSRQAMQGMPVRNTGSPKSAVKTRQAFFLHTTYFTK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD FARQVCKNTLRLRQAARRPFVAINYAAIRAEYADRHAELSGSPLKSKSTRKPLACIIGYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FARQVCKNTLRLRQAARRPFVAINYAAIRAEYADRHAELSGSPLKSKSTRKPLACIIGYL 430 440 450 460 470 480 490 500 510 520 530 pF1KSD EIHPAKKPNVIRSTPSLQTPTTKRMLTTPNHTSLSILGKRNYSHHNGLDELTCCVSD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIHPAKKPNVIRSTPSLQTPTTKRMLTTPNHTSLSILGKRNYSHHNGLDELTCCVSD 490 500 510 520 530 >>NP_001269684 (OMIM: 609050) metastasis-associated prot (537 aa) initn: 3596 init1: 3596 opt: 3596 Z-score: 4056.9 bits: 760.4 E(85289): 0 Smith-Waterman score: 3596; 100.0% identity (100.0% similar) in 537 aa overlap (1-537:1-537) 10 20 30 40 50 60 pF1KSD MLADKHAKEIEEESETTVEADLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLADKHAKEIEEESETTVEADLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD TESVLSYLDKEDTFFYSLVYDPSLKTLLADKGEIRVGPRYQADIPEMLLEGESDEREQSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TESVLSYLDKEDTFFYSLVYDPSLKTLLADKGEIRVGPRYQADIPEMLLEGESDEREQSK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LEVKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEVKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD AMDTLYRHSYDLSSAISVLVPLGGPVLCRDEMEEWSASEASLFEEALEKYGKDFNDIRQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AMDTLYRHSYDLSSAISVLVPLGGPVLCRDEMEEWSASEASLFEEALEKYGKDFNDIRQD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD FLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYKPNPNQISTSNGKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYKPNPNQISTSNGKP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD GAVNGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAVNGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGLK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD MPTQSEEEKLSPSPTTEDPRVRSHVSRQAMQGMPVRNTGSPKSAVKTRQAFFLHTTYFTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPTQSEEEKLSPSPTTEDPRVRSHVSRQAMQGMPVRNTGSPKSAVKTRQAFFLHTTYFTK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD FARQVCKNTLRLRQAARRPFVAINYAAIRAEYADRHAELSGSPLKSKSTRKPLACIIGYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FARQVCKNTLRLRQAARRPFVAINYAAIRAEYADRHAELSGSPLKSKSTRKPLACIIGYL 430 440 450 460 470 480 490 500 510 520 530 pF1KSD EIHPAKKPNVIRSTPSLQTPTTKRMLTTPNHTSLSILGKRNYSHHNGLDELTCCVSD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIHPAKKPNVIRSTPSLQTPTTKRMLTTPNHTSLSILGKRNYSHHNGLDELTCCVSD 490 500 510 520 530 >>NP_001317372 (OMIM: 609050) metastasis-associated prot (593 aa) initn: 3596 init1: 3596 opt: 3596 Z-score: 4056.2 bits: 760.4 E(85289): 0 Smith-Waterman score: 3596; 100.0% identity (100.0% similar) in 537 aa overlap (1-537:57-593) 10 20 30 pF1KSD MLADKHAKEIEEESETTVEADLTDKQKHQL :::::::::::::::::::::::::::::: NP_001 IEELNKTASGNVEAKVVCFYRRRDISNTLIMLADKHAKEIEEESETTVEADLTDKQKHQL 30 40 50 60 70 80 40 50 60 70 80 90 pF1KSD KHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSLKTLLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSLKTLLAD 90 100 110 120 130 140 100 110 120 130 140 150 pF1KSD KGEIRVGPRYQADIPEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGEIRVGPRYQADIPEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTF 150 160 170 180 190 200 160 170 180 190 200 210 pF1KSD ARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYRHSYDLSSAISVLVPLGGPVLCRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYRHSYDLSSAISVLVPLGGPVLCRD 210 220 230 240 250 260 220 230 240 250 260 270 pF1KSD EMEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EMEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLK 270 280 290 300 310 320 280 290 300 310 320 330 pF1KSD AAEAESKLKQVYIPTYKPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAEAESKLKQVYIPTYKPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQS 330 340 350 360 370 380 340 350 360 370 380 390 pF1KSD HQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQAM 390 400 410 420 430 440 400 410 420 430 440 450 pF1KSD QGMPVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGMPVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIRA 450 460 470 480 490 500 460 470 480 490 500 510 pF1KSD EYADRHAELSGSPLKSKSTRKPLACIIGYLEIHPAKKPNVIRSTPSLQTPTTKRMLTTPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYADRHAELSGSPLKSKSTRKPLACIIGYLEIHPAKKPNVIRSTPSLQTPTTKRMLTTPN 510 520 530 540 550 560 520 530 pF1KSD HTSLSILGKRNYSHHNGLDELTCCVSD ::::::::::::::::::::::::::: NP_001 HTSLSILGKRNYSHHNGLDELTCCVSD 570 580 590 >>XP_005264516 (OMIM: 609050) PREDICTED: metastasis-asso (538 aa) initn: 3582 init1: 1861 opt: 3584 Z-score: 4043.3 bits: 757.9 E(85289): 1.8e-218 Smith-Waterman score: 3584; 99.8% identity (99.8% similar) in 538 aa overlap (1-537:1-538) 10 20 30 40 50 60 pF1KSD MLADKHAKEIEEESETTVEADLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLADKHAKEIEEESETTVEADLTDKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD TESVLSYLDKEDTFFYSLVYDPSLKTLLADKGEIRVGPRYQADIPEMLLEGESDEREQSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TESVLSYLDKEDTFFYSLVYDPSLKTLLADKGEIRVGPRYQADIPEMLLEGESDEREQSK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LEVKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEVKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD AMDTLYRHSYDLSSAISVLVPLGGPVLCRDEMEEWSASEASLFEEALEKYGKDFNDIRQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AMDTLYRHSYDLSSAISVLVPLGGPVLCRDEMEEWSASEASLFEEALEKYGKDFNDIRQD 190 200 210 220 230 240 250 260 270 280 290 pF1KSD FLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTY-KPNPNQISTSNGK :::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::: XP_005 FLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYSKPNPNQISTSNGK 250 260 270 280 290 300 300 310 320 330 340 350 pF1KSD PGAVNGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGAVNGAVGTTFQPQNPLLGRACESCYATQSHQWYSWGPPNMQCRLCAICWLYWKKYGGL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KSD KMPTQSEEEKLSPSPTTEDPRVRSHVSRQAMQGMPVRNTGSPKSAVKTRQAFFLHTTYFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KMPTQSEEEKLSPSPTTEDPRVRSHVSRQAMQGMPVRNTGSPKSAVKTRQAFFLHTTYFT 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD KFARQVCKNTLRLRQAARRPFVAINYAAIRAEYADRHAELSGSPLKSKSTRKPLACIIGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KFARQVCKNTLRLRQAARRPFVAINYAAIRAEYADRHAELSGSPLKSKSTRKPLACIIGY 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD LEIHPAKKPNVIRSTPSLQTPTTKRMLTTPNHTSLSILGKRNYSHHNGLDELTCCVSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEIHPAKKPNVIRSTPSLQTPTTKRMLTTPNHTSLSILGKRNYSHHNGLDELTCCVSD 490 500 510 520 530 >>NP_001317371 (OMIM: 609050) metastasis-associated prot (594 aa) initn: 3582 init1: 1861 opt: 3584 Z-score: 4042.7 bits: 757.9 E(85289): 1.9e-218 Smith-Waterman score: 3584; 99.8% identity (99.8% similar) in 538 aa overlap (1-537:57-594) 10 20 30 pF1KSD MLADKHAKEIEEESETTVEADLTDKQKHQL :::::::::::::::::::::::::::::: NP_001 IEELNKTASGNVEAKVVCFYRRRDISNTLIMLADKHAKEIEEESETTVEADLTDKQKHQL 30 40 50 60 70 80 40 50 60 70 80 90 pF1KSD KHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSLKTLLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSLKTLLAD 90 100 110 120 130 140 100 110 120 130 140 150 pF1KSD KGEIRVGPRYQADIPEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGEIRVGPRYQADIPEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTF 150 160 170 180 190 200 160 170 180 190 200 210 pF1KSD ARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYRHSYDLSSAISVLVPLGGPVLCRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYRHSYDLSSAISVLVPLGGPVLCRD 210 220 230 240 250 260 220 230 240 250 260 270 pF1KSD EMEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EMEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLK 270 280 290 300 310 320 280 290 300 310 320 pF1KSD AAEAESKLKQVYIPTY-KPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQ :::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: NP_001 AAEAESKLKQVYIPTYSKPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQ 330 340 350 360 370 380 330 340 350 360 370 380 pF1KSD SHQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQA 390 400 410 420 430 440 390 400 410 420 430 440 pF1KSD MQGMPVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQGMPVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIR 450 460 470 480 490 500 450 460 470 480 490 500 pF1KSD AEYADRHAELSGSPLKSKSTRKPLACIIGYLEIHPAKKPNVIRSTPSLQTPTTKRMLTTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEYADRHAELSGSPLKSKSTRKPLACIIGYLEIHPAKKPNVIRSTPSLQTPTTKRMLTTP 510 520 530 540 550 560 510 520 530 pF1KSD NHTSLSILGKRNYSHHNGLDELTCCVSD :::::::::::::::::::::::::::: NP_001 NHTSLSILGKRNYSHHNGLDELTCCVSD 570 580 590 >>NP_065795 (OMIM: 609050) metastasis-associated protein (515 aa) initn: 3006 init1: 1861 opt: 3008 Z-score: 3393.9 bits: 637.6 E(85289): 2.7e-182 Smith-Waterman score: 3008; 99.8% identity (99.8% similar) in 452 aa overlap (1-451:57-508) 10 20 30 pF1KSD MLADKHAKEIEEESETTVEADLTDKQKHQL :::::::::::::::::::::::::::::: NP_065 IEELNKTASGNVEAKVVCFYRRRDISNTLIMLADKHAKEIEEESETTVEADLTDKQKHQL 30 40 50 60 70 80 40 50 60 70 80 90 pF1KSD KHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSLKTLLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 KHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSLKTLLAD 90 100 110 120 130 140 100 110 120 130 140 150 pF1KSD KGEIRVGPRYQADIPEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 KGEIRVGPRYQADIPEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTF 150 160 170 180 190 200 160 170 180 190 200 210 pF1KSD ARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYRHSYDLSSAISVLVPLGGPVLCRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 ARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYRHSYDLSSAISVLVPLGGPVLCRD 210 220 230 240 250 260 220 230 240 250 260 270 pF1KSD EMEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 EMEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLK 270 280 290 300 310 320 280 290 300 310 320 pF1KSD AAEAESKLKQVYIPTY-KPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQ :::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: NP_065 AAEAESKLKQVYIPTYSKPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQ 330 340 350 360 370 380 330 340 350 360 370 380 pF1KSD SHQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SHQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQA 390 400 410 420 430 440 390 400 410 420 430 440 pF1KSD MQGMPVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MQGMPVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIR 450 460 470 480 490 500 450 460 470 480 490 500 pF1KSD AEYADRHAELSGSPLKSKSTRKPLACIIGYLEIHPAKKPNVIRSTPSLQTPTTKRMLTTP :: NP_065 AECKMLLNS 510 >>NP_001317373 (OMIM: 609050) metastasis-associated prot (530 aa) initn: 2033 init1: 2033 opt: 2033 Z-score: 2293.8 bits: 434.1 E(85289): 5e-121 Smith-Waterman score: 3036; 88.3% identity (88.3% similar) in 537 aa overlap (1-537:57-530) 10 20 30 pF1KSD MLADKHAKEIEEESETTVEADLTDKQKHQL :::::::::::::::::::::::::::::: NP_001 IEELNKTASGNVEAKVVCFYRRRDISNTLIMLADKHAKEIEEESETTVEADLTDKQKHQL 30 40 50 60 70 80 40 50 60 70 80 90 pF1KSD KHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSLKTLLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSLKTLLAD 90 100 110 120 130 140 100 110 120 130 140 150 pF1KSD KGEIRVGPRYQADIPEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KGEIRVGPRYQADIPEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTF 150 160 170 180 190 200 160 170 180 190 200 210 pF1KSD ARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYRHSYDLSSAISVLVPLGGPVLCRD :::::::::::::::::::::::::::: NP_001 ARALDCSSSVRQPSLHMSAAAASRDITL-------------------------------- 210 220 230 220 230 240 250 260 270 pF1KSD EMEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLK ::::::::::::::::::::::::::::: NP_001 -------------------------------LPWKSLTSIIEYYYMWKTTDRYVQQKRLK 240 250 260 280 290 300 310 320 330 pF1KSD AAEAESKLKQVYIPTYKPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAEAESKLKQVYIPTYKPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQS 270 280 290 300 310 320 340 350 360 370 380 390 pF1KSD HQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQAM 330 340 350 360 370 380 400 410 420 430 440 450 pF1KSD QGMPVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QGMPVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIRA 390 400 410 420 430 440 460 470 480 490 500 510 pF1KSD EYADRHAELSGSPLKSKSTRKPLACIIGYLEIHPAKKPNVIRSTPSLQTPTTKRMLTTPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYADRHAELSGSPLKSKSTRKPLACIIGYLEIHPAKKPNVIRSTPSLQTPTTKRMLTTPN 450 460 470 480 490 500 520 530 pF1KSD HTSLSILGKRNYSHHNGLDELTCCVSD ::::::::::::::::::::::::::: NP_001 HTSLSILGKRNYSHHNGLDELTCCVSD 510 520 530 >>XP_016877247 (OMIM: 603526) PREDICTED: metastasis-asso (726 aa) initn: 2041 init1: 1560 opt: 1997 Z-score: 2251.1 bits: 426.7 E(85289): 1.2e-118 Smith-Waterman score: 2383; 69.4% identity (84.8% similar) in 532 aa overlap (2-529:58-575) 10 20 30 pF1KSD MLADKHAKEIEEESETTVEADLTDKQKHQLK ::::::.::::: :. .:: .: ::::. XP_016 EELNKTANGNVEAKVVCFYRRRDISSTLIALADKHAREIEEEMENPEMVDLPEKLKHQLR 30 40 50 60 70 80 40 50 60 70 80 90 pF1KSD HRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSLKTLLADK ::::::::: ::::::::::::::.:::::::. :::..:: :::::::::. ::::::: XP_016 HRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADK 90 100 110 120 130 140 100 110 120 130 140 150 pF1KSD GEIRVGPRYQADIPEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTFA :::::: :::::: ..: ::: : :.::.::..::. ..::::.::::::::::.::::: XP_016 GEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARSVGTFA 150 160 170 180 190 200 160 170 180 190 200 210 pF1KSD RALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYRHSYDLSSAISVLVPLGGPVLCRDE ::::::::::::::::::::::::::::::::::... ::.:.:::.::: ::::::::: XP_016 RALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDE 210 220 230 240 250 260 220 230 240 250 260 270 pF1KSD MEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKA :::::::::.:::::::::::::.::.::::::::::::::::::::::::::::::::: XP_016 MEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKA 270 280 290 300 310 320 280 290 300 310 320 330 pF1KSD AEAESKLKQVYIPTY-KPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQS :::::::::::::.: ::::::::..: : :.::: : :.: ::::::::.::: XP_016 AEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNG---TGAPGQSPGAGRACESCYTTQS 330 340 350 360 370 380 340 350 360 370 380 390 pF1KSD HQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQAM .:::::::::::::::: :: ::::::::::::. . :. :.:. ::..: XP_016 YQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGER--PGPN------RSNMS---P 390 400 410 420 430 400 410 420 430 440 450 pF1KSD QGMPVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIRA .:.:.:..:::: :.::::::.:::: .:..::..:.. :: .:::.:.. :: :::.: XP_016 HGLPARSSGSPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKA 440 450 460 470 480 490 460 470 480 490 500 pF1KSD EYADRHAELSGSPLKSK-STRKPLACIIGYLEIHP-AKKPNVIRSTPS-LQTPTTKRMLT : . : : : ::: : ..:::: .. ::: :: ::. ..:. : :.. : .. XP_016 ECTARLPEASQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAP 500 510 520 530 540 550 510 520 530 pF1KSD TPNHTSLSILGKRNYSHHNGLDELTCCVSD . :. : .:::::.: .:::.: XP_016 VINNGSPTILGKRSYEQHNGVDGNMKKRLLMPSRGTYLGLANHGQARHMGPSRNLLLNGK 560 570 580 590 600 610 >>XP_011535612 (OMIM: 603526) PREDICTED: metastasis-asso (742 aa) initn: 2043 init1: 1560 opt: 1997 Z-score: 2250.9 bits: 426.7 E(85289): 1.2e-118 Smith-Waterman score: 2385; 69.3% identity (84.6% similar) in 534 aa overlap (2-531:114-633) 10 20 30 pF1KSD MLADKHAKEIEEESETTVEADLTDKQKHQLK ::::::.::::: :. .:: .: ::::. XP_011 EELNKTANGNVEAKVVCFYRRRDISSTLIALADKHAREIEEEMENPEMVDLPEKLKHQLR 90 100 110 120 130 140 40 50 60 70 80 90 pF1KSD HRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSLKTLLADK ::::::::: ::::::::::::::.:::::::. :::..:: :::::::::. ::::::: XP_011 HRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADK 150 160 170 180 190 200 100 110 120 130 140 150 pF1KSD GEIRVGPRYQADIPEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTFA :::::: :::::: ..: ::: : :.::.::..::. ..::::.::::::::::.::::: XP_011 GEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARSVGTFA 210 220 230 240 250 260 160 170 180 190 200 210 pF1KSD RALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYRHSYDLSSAISVLVPLGGPVLCRDE ::::::::::::::::::::::::::::::::::... ::.:.:::.::: ::::::::: XP_011 RALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDE 270 280 290 300 310 320 220 230 240 250 260 270 pF1KSD MEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKA :::::::::.:::::::::::::.::.::::::::::::::::::::::::::::::::: XP_011 MEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKA 330 340 350 360 370 380 280 290 300 310 320 330 pF1KSD AEAESKLKQVYIPTY-KPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQS :::::::::::::.: ::::::::..: : :.:: :: :.: ::::::::.::: XP_011 AEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVN---GTGAPGQSPGAGRACESCYTTQS 390 400 410 420 430 440 340 350 360 370 380 390 pF1KSD HQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQAM .:::::::::::::::: :: ::::::::::::. . :. :.:. ::..: XP_011 YQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGER--PGPN------RSNMS---P 450 460 470 480 400 410 420 430 440 450 pF1KSD QGMPVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIRA .:.:.:..:::: :.::::::.:::: .:..::..:.. :: .:::.:.. :: :::.: XP_011 HGLPARSSGSPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKA 490 500 510 520 530 540 460 470 480 490 500 pF1KSD EYADRHAELSGSPLKSK-STRKPLACIIGYLEIHP-AKKPNVIRSTPS-LQTPTTKRMLT : . : : : ::: : ..:::: .. ::: :: ::. ..:. : :.. : .. XP_011 ECTARLPEASQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAP 550 560 570 580 590 600 510 520 530 pF1KSD TPNHTSLSILGKRNYSHHNGLDELTCCVSD . :. : .:::::.: .:::.: : XP_011 VINNGSPTILGKRSYEQHNGVDGLANHGQARHMGPSRNLLLNGKSYPTKVRLIRGGSLPP 610 620 630 640 650 660 >>XP_011535611 (OMIM: 603526) PREDICTED: metastasis-asso (754 aa) initn: 2041 init1: 1560 opt: 1997 Z-score: 2250.8 bits: 426.7 E(85289): 1.2e-118 Smith-Waterman score: 2383; 69.4% identity (84.8% similar) in 532 aa overlap (2-529:114-631) 10 20 30 pF1KSD MLADKHAKEIEEESETTVEADLTDKQKHQLK ::::::.::::: :. .:: .: ::::. XP_011 EELNKTANGNVEAKVVCFYRRRDISSTLIALADKHAREIEEEMENPEMVDLPEKLKHQLR 90 100 110 120 130 140 40 50 60 70 80 90 pF1KSD HRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSLKTLLADK ::::::::: ::::::::::::::.:::::::. :::..:: :::::::::. ::::::: XP_011 HRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADK 150 160 170 180 190 200 100 110 120 130 140 150 pF1KSD GEIRVGPRYQADIPEMLLEGESDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTFA :::::: :::::: ..: ::: : :.::.::..::. ..::::.::::::::::.::::: XP_011 GEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARSVGTFA 210 220 230 240 250 260 160 170 180 190 200 210 pF1KSD RALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYRHSYDLSSAISVLVPLGGPVLCRDE ::::::::::::::::::::::::::::::::::... ::.:.:::.::: ::::::::: XP_011 RALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDE 270 280 290 300 310 320 220 230 240 250 260 270 pF1KSD MEEWSASEASLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKA :::::::::.:::::::::::::.::.::::::::::::::::::::::::::::::::: XP_011 MEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKA 330 340 350 360 370 380 280 290 300 310 320 330 pF1KSD AEAESKLKQVYIPTY-KPNPNQISTSNGKPGAVNGAVGTTFQPQNPLLGRACESCYATQS :::::::::::::.: ::::::::..: : :.::: : :.: ::::::::.::: XP_011 AEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNG---TGAPGQSPGAGRACESCYTTQS 390 400 410 420 430 440 340 350 360 370 380 390 pF1KSD HQWYSWGPPNMQCRLCAICWLYWKKYGGLKMPTQSEEEKLSPSPTTEDPRVRSHVSRQAM .:::::::::::::::: :: ::::::::::::. . :. :.:. ::..: XP_011 YQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGER--PGPN------RSNMS---P 450 460 470 480 400 410 420 430 440 450 pF1KSD QGMPVRNTGSPKSAVKTRQAFFLHTTYFTKFARQVCKNTLRLRQAARRPFVAINYAAIRA .:.:.:..:::: :.::::::.:::: .:..::..:.. :: .:::.:.. :: :::.: XP_011 HGLPARSSGSPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYLPINSAAIKA 490 500 510 520 530 540 460 470 480 490 500 pF1KSD EYADRHAELSGSPLKSK-STRKPLACIIGYLEIHP-AKKPNVIRSTPS-LQTPTTKRMLT : . : : : ::: : ..:::: .. ::: :: ::. ..:. : :.. : .. XP_011 ECTARLPEASQSPLVLKQAVRKPLEAVLRYLETHPRPPKPDPVKSVSSVLSSLTPAKVAP 550 560 570 580 590 600 510 520 530 pF1KSD TPNHTSLSILGKRNYSHHNGLDELTCCVSD . :. : .:::::.: .:::.: XP_011 VINNGSPTILGKRSYEQHNGVDGNMKKRLLMPSRGLANHGQARHMGPSRNLLLNGKSYPT 610 620 630 640 650 660 537 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 05:40:04 2016 done: Thu Nov 3 05:40:06 2016 Total Scan time: 10.260 Total Display time: 0.130 Function used was FASTA [36.3.4 Apr, 2011]