FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1276, 1060 aa 1>>>pF1KSDA1276 1060 - 1060 aa - 1060 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.0545+/-0.00117; mu= -7.5642+/- 0.069 mean_var=476.1423+/-101.985, 0's: 0 Z-trim(112.6): 163 B-trim: 0 in 0/54 Lambda= 0.058777 statistics sampled from 13169 (13308) to 13169 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.723), E-opt: 0.2 (0.409), width: 16 Scan time: 4.360 The best scores are: opt bits E(32554) CCDS47033.1 FAM184B gene_id:27146|Hs108|chr4 (1060) 6816 593.7 6.8e-169 CCDS43499.1 FAM184A gene_id:79632|Hs108|chr6 (1140) 750 79.4 5e-14 >>CCDS47033.1 FAM184B gene_id:27146|Hs108|chr4 (1060 aa) initn: 6816 init1: 6816 opt: 6816 Z-score: 3145.6 bits: 593.7 E(32554): 6.8e-169 Smith-Waterman score: 6816; 99.6% identity (99.8% similar) in 1060 aa overlap (1-1060:1-1060) 10 20 30 40 50 60 pF1KSD MASALNSKINPPGTCQGSKADGGAGWRMDCDPQMHVKMCKKIAQLTKVIYALNTRQDEAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 MASALNSKINPPGTCQGSKADGGAGWRMDCDPQMHVKMCKKIAQLTKVIYALNTRQDEAE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD ASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 ASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD ESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 ESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQES 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD PETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 PETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD SQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: : CCDS47 SQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 DVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD NDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 NDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD KKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 KKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD EEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 EEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD TSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 TSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD QKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQHELQETTQQNHAMKAQLE ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: CCDS47 QKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD ASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQEERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 ASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQEERE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD RMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 RMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD TEEWGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRR ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 TEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRR 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD FLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 FLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKG 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD ASRPEDLQLIGRLQTRLKEREDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHPGYLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 ASRPEDLQLIGRLQTRLKEREDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHPGYLTP 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD SMKKKKVEDVPSRVVSVPNLASYAKNFLSGDLSSRINAPPITTSPSLDPSPSCGRTYKPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 SMKKKKVEDVPSRVVSVPNLASYAKNFLSGDLSSRINAPPITTSPSLDPSPSCGRTYKPN 970 980 990 1000 1010 1020 1030 1040 1050 1060 pF1KSD QSTDAKTATRTPDGETAQAKEAQQKQGSPHQEWFTKYFSF :::::::::::::::::::::.:::::::::::::::::: CCDS47 QSTDAKTATRTPDGETAQAKEVQQKQGSPHQEWFTKYFSF 1030 1040 1050 1060 >>CCDS43499.1 FAM184A gene_id:79632|Hs108|chr6 (1140 aa) initn: 1236 init1: 295 opt: 750 Z-score: 365.3 bits: 79.4 E(32554): 5e-14 Smith-Waterman score: 1161; 27.1% identity (59.5% similar) in 1112 aa overlap (51-1060:57-1140) 30 40 50 60 70 80 pF1KSD DGGAGWRMDCDPQMHVKMCKKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAE ::::..:: :....::..::.::.:. .:: CCDS43 AQLAGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAE 30 40 50 60 70 80 90 100 110 120 130 pF1KSD TKARLLQEQGCAEEEALLQR-IQALESALELQKRLTEEALAESASCRLETKERELRVEAE :. ..:: .. . :: :.: ::.:::.:: . .. ..::.: . . .... .: .::. CCDS43 TREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQ 90 100 110 120 130 140 140 150 160 170 180 pF1KSD HAERVLTLSREMLELKADYERRLQHL-------------------TSHEATPQGRLPQES :..:..:.:::. :.. .:..:. . ..:. : : ... CCDS43 HVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQ 150 160 170 180 190 200 190 200 210 220 230 pF1KSD PETKS-EPGQ--GPEMQEVLLE-----VQRLRVENQQLSKDYARKAEELQATYERENEAI .. : . :: . :.... .: ...::.: ..: .:: : .. :. :::: ... CCDS43 DHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTL 210 220 230 240 250 260 240 250 260 270 280 290 pF1KSD RQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQK ... : ....: .:::.::::.:: ::. :. . ::. .:. . ..: :: CCDS43 KRS-QLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQK 270 280 290 300 310 320 300 310 320 330 pF1KSD LK-------ERIQHLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECR------- :. . .: :. :: .:.. . : . :.. .::.:..:.. : CCDS43 LQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASH 330 340 350 360 370 380 340 350 360 370 380 390 pF1KSD -GTQQTDAMKTE-----LVSENKVLREE-NDLEAGNLHPQQDQSCLKECPCMKGGTDMQT : :. : : : ::.. . :. ..:: .. . : : .. .. CCDS43 IGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQI---LEL 390 400 410 420 430 440 400 410 420 430 440 450 pF1KSD KKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVE .:... . ... ::..:.... . ::: .:.. : ::.:. :: . :..:.:.. CCDS43 EKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAI 450 460 470 480 490 500 460 470 480 490 500 pF1KSD AERKKLQREVEAQLEEVRKKSEKEIKQLEEE----KAALNVKLQNSLLEVLRLEEFIQQN ..:::: ..: : .. . . :.. .::..: : .:. ::... :. .:....... CCDS43 RDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKS 510 520 530 540 550 560 510 520 530 540 550 pF1KSD KTRPTGAE------ESPQE-----LGRQHCSILETQDPCLKLD-ETSPRGEEYQDKLAA- . .:: .. :: : . :. ::.: :... : . ..... .:: CCDS43 EQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 570 580 590 600 610 620 560 570 580 590 pF1KSD --EEGTSSDE--------------EE----RTKVLLKEGSDPQPPLGSLLKEKTSKIQRL :: . :. .: : .. :.. : . ...::. : . . CCDS43 KEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAA 630 640 650 660 670 680 600 610 620 630 640 650 pF1KSD EEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQHELQETTQQNHA ...::.. : :.: ..: :: :. . .:: :. ::..: .::.: .:.. CCDS43 RDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQ 690 700 710 720 730 740 660 670 680 690 700 710 pF1KSD MKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQE . .:. .: :.. .:. ...: .: :..:... : :: ...:: ..... . .:: CCDS43 RHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQE 750 760 770 780 790 800 720 730 740 750 760 pF1KSD LQEERERMQAQQALLLESLRQELSEQQAAC-----SGHQKDLEALQAELRA---LGRQQA :: : ... . .: :::.::..:.:: .:...: : . ::. ..:.: CCDS43 LQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQ- 810 820 830 840 850 860 770 780 790 800 810 820 pF1KSD SSQCPGDSKDHIIATEEWGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVE ::.:: . . . . : .: .:.. . : :.: CCDS43 -------SKEHICRITDLQEELR---------HREHHISELDKEVQHLHENISALTKELE 870 880 890 900 830 840 850 860 870 880 pF1KSD QHQQEAQKLRD----QRRFLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQAR . .: ..:. : :. :. . . .:.... .: .: . : :::.... :. CCDS43 FKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEI 910 920 930 940 950 960 890 900 910 920 930 940 pF1KSD LAALEAELKDSGEKPGKGASRPEDLQLIGRLQTRLKEREDIIKQLTEERRFHYAAFPSAM :::.. :.. :: :.:::.:.: .:.. : ::..:::.: :. .:. . . CCDS43 NAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLELVNRE 970 980 990 1000 1010 1020 950 960 970 980 990 1000 pF1KSD SHRNRSFSFNPHPGYLTPSMKKKKVED-VPS-RVVSVPNLASYAKNFLSGDLSSRINAPP .. :. :. .: : ..: :.:: .: :. : ::::::.. .. ... .:.. : CCDS43 TNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNRLD--P 1030 1040 1050 1060 1070 1080 1010 1020 1030 1040 1050 pF1KSD ITTSPSLDPSPSCGRTY-KPNQSTDAKTATRTPDGETAQAKEAQQKQGSPH-QEWFTKYF : .:: : . .. .: :: .: ::.. . . .:. ::::..:: CCDS43 IPNSPVHDIEFNSSKPLPQPVPPKGPKTFL-SP----AQSEASPVASPDPQRQEWFARYF 1090 1100 1110 1120 1130 1060 pF1KSD SF .: CCDS43 TF 1140 1060 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 05:42:44 2016 done: Thu Nov 3 05:42:44 2016 Total Scan time: 4.360 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]