FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1293, 419 aa 1>>>pF1KSDA1293 419 - 419 aa - 419 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0915+/-0.00041; mu= 18.1477+/- 0.025 mean_var=63.5599+/-12.830, 0's: 0 Z-trim(111.5): 12 B-trim: 28 in 1/48 Lambda= 0.160873 statistics sampled from 20145 (20153) to 20145 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.236), width: 16 Scan time: 8.680 The best scores are: opt bits E(85289) NP_001995 (OMIM: 134629,616631) farnesyl pyrophosp ( 419) 2841 668.4 9.5e-192 NP_001129293 (OMIM: 134629,616631) farnesyl pyroph ( 419) 2841 668.4 9.5e-192 XP_005245019 (OMIM: 134629,616631) PREDICTED: farn ( 353) 2339 551.8 9.8e-157 XP_005245020 (OMIM: 134629,616631) PREDICTED: farn ( 353) 2339 551.8 9.8e-157 NP_001229753 (OMIM: 134629,616631) farnesyl pyroph ( 353) 2339 551.8 9.8e-157 NP_001129294 (OMIM: 134629,616631) farnesyl pyroph ( 353) 2339 551.8 9.8e-157 NP_001229754 (OMIM: 134629,616631) farnesyl pyroph ( 248) 1641 389.7 4.3e-108 >>NP_001995 (OMIM: 134629,616631) farnesyl pyrophosphate (419 aa) initn: 2841 init1: 2841 opt: 2841 Z-score: 3563.4 bits: 668.4 E(85289): 9.5e-192 Smith-Waterman score: 2841; 100.0% identity (100.0% similar) in 419 aa overlap (1-419:1-419) 10 20 30 40 50 60 pF1KSD MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE 310 320 330 340 350 360 370 380 390 400 410 pF1KSD AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK 370 380 390 400 410 >>NP_001129293 (OMIM: 134629,616631) farnesyl pyrophosph (419 aa) initn: 2841 init1: 2841 opt: 2841 Z-score: 3563.4 bits: 668.4 E(85289): 9.5e-192 Smith-Waterman score: 2841; 100.0% identity (100.0% similar) in 419 aa overlap (1-419:1-419) 10 20 30 40 50 60 pF1KSD MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE 310 320 330 340 350 360 370 380 390 400 410 pF1KSD AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK 370 380 390 400 410 >>XP_005245019 (OMIM: 134629,616631) PREDICTED: farnesyl (353 aa) initn: 2339 init1: 2339 opt: 2339 Z-score: 2934.9 bits: 551.8 E(85289): 9.8e-157 Smith-Waterman score: 2339; 100.0% identity (100.0% similar) in 353 aa overlap (67-419:1-353) 40 50 60 70 80 90 pF1KSD HGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTE :::::::::::::::::::::::::::::: XP_005 MNGDQNSDVYAQEKQDFVQHFSQIVRVLTE 10 20 30 100 110 120 130 140 150 pF1KSD DEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGW 40 50 60 70 80 90 160 170 180 190 200 210 pF1KSD CVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQ 100 110 120 130 140 150 220 230 240 250 260 270 pF1KSD PYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPI 160 170 180 190 200 210 280 290 300 310 320 330 pF1KSD AAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWL 220 230 240 250 260 270 340 350 360 370 380 390 pF1KSD VVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIE 280 290 300 310 320 330 400 410 pF1KSD QYAAPLPPAVFLGLARKIYKRRK ::::::::::::::::::::::: XP_005 QYAAPLPPAVFLGLARKIYKRRK 340 350 >>XP_005245020 (OMIM: 134629,616631) PREDICTED: farnesyl (353 aa) initn: 2339 init1: 2339 opt: 2339 Z-score: 2934.9 bits: 551.8 E(85289): 9.8e-157 Smith-Waterman score: 2339; 100.0% identity (100.0% similar) in 353 aa overlap (67-419:1-353) 40 50 60 70 80 90 pF1KSD HGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTE :::::::::::::::::::::::::::::: XP_005 MNGDQNSDVYAQEKQDFVQHFSQIVRVLTE 10 20 30 100 110 120 130 140 150 pF1KSD DEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGW 40 50 60 70 80 90 160 170 180 190 200 210 pF1KSD CVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQ 100 110 120 130 140 150 220 230 240 250 260 270 pF1KSD PYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPI 160 170 180 190 200 210 280 290 300 310 320 330 pF1KSD AAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWL 220 230 240 250 260 270 340 350 360 370 380 390 pF1KSD VVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIE 280 290 300 310 320 330 400 410 pF1KSD QYAAPLPPAVFLGLARKIYKRRK ::::::::::::::::::::::: XP_005 QYAAPLPPAVFLGLARKIYKRRK 340 350 >>NP_001229753 (OMIM: 134629,616631) farnesyl pyrophosph (353 aa) initn: 2339 init1: 2339 opt: 2339 Z-score: 2934.9 bits: 551.8 E(85289): 9.8e-157 Smith-Waterman score: 2339; 100.0% identity (100.0% similar) in 353 aa overlap (67-419:1-353) 40 50 60 70 80 90 pF1KSD HGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTE :::::::::::::::::::::::::::::: NP_001 MNGDQNSDVYAQEKQDFVQHFSQIVRVLTE 10 20 30 100 110 120 130 140 150 pF1KSD DEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGW 40 50 60 70 80 90 160 170 180 190 200 210 pF1KSD CVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQ 100 110 120 130 140 150 220 230 240 250 260 270 pF1KSD PYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPI 160 170 180 190 200 210 280 290 300 310 320 330 pF1KSD AAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWL 220 230 240 250 260 270 340 350 360 370 380 390 pF1KSD VVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIE 280 290 300 310 320 330 400 410 pF1KSD QYAAPLPPAVFLGLARKIYKRRK ::::::::::::::::::::::: NP_001 QYAAPLPPAVFLGLARKIYKRRK 340 350 >>NP_001129294 (OMIM: 134629,616631) farnesyl pyrophosph (353 aa) initn: 2339 init1: 2339 opt: 2339 Z-score: 2934.9 bits: 551.8 E(85289): 9.8e-157 Smith-Waterman score: 2339; 100.0% identity (100.0% similar) in 353 aa overlap (67-419:1-353) 40 50 60 70 80 90 pF1KSD HGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTE :::::::::::::::::::::::::::::: NP_001 MNGDQNSDVYAQEKQDFVQHFSQIVRVLTE 10 20 30 100 110 120 130 140 150 pF1KSD DEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGW 40 50 60 70 80 90 160 170 180 190 200 210 pF1KSD CVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQ 100 110 120 130 140 150 220 230 240 250 260 270 pF1KSD PYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPI 160 170 180 190 200 210 280 290 300 310 320 330 pF1KSD AAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWL 220 230 240 250 260 270 340 350 360 370 380 390 pF1KSD VVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIE 280 290 300 310 320 330 400 410 pF1KSD QYAAPLPPAVFLGLARKIYKRRK ::::::::::::::::::::::: NP_001 QYAAPLPPAVFLGLARKIYKRRK 340 350 >>NP_001229754 (OMIM: 134629,616631) farnesyl pyrophosph (248 aa) initn: 1641 init1: 1641 opt: 1641 Z-score: 2061.6 bits: 389.7 E(85289): 4.3e-108 Smith-Waterman score: 1641; 100.0% identity (100.0% similar) in 248 aa overlap (172-419:1-248) 150 160 170 180 190 200 pF1KSD KQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLL :::::::::::::::::::::::::::::: NP_001 MDSSLTRRGQICWYQKPGVGLDAINDANLL 10 20 30 210 220 230 240 250 260 pF1KSD EACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKS 40 50 60 70 80 90 270 280 290 300 310 320 pF1KSD IVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVT 100 110 120 130 140 150 330 340 350 360 370 380 pF1KSD GKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFL 160 170 180 190 200 210 390 400 410 pF1KSD QYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK :::::::::::::::::::::::::::::::::::::: NP_001 QYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK 220 230 240 419 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 05:47:10 2016 done: Thu Nov 3 05:47:11 2016 Total Scan time: 8.680 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]