FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1345, 1512 aa 1>>>pF1KSDA1345 1512 - 1512 aa - 1512 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.1676+/-0.00101; mu= 10.4908+/- 0.061 mean_var=146.8662+/-28.864, 0's: 0 Z-trim(108.4): 20 B-trim: 13 in 1/54 Lambda= 0.105831 statistics sampled from 10185 (10194) to 10185 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.659), E-opt: 0.2 (0.313), width: 16 Scan time: 4.930 The best scores are: opt bits E(32554) CCDS47026.1 CC2D2A gene_id:57545|Hs108|chr4 (1620) 7608 1174.5 0 CCDS53560.1 CC2D2B gene_id:387707|Hs108|chr10 ( 401) 1339 217.1 8.9e-56 CCDS41555.1 CC2D2B gene_id:387707|Hs108|chr10 ( 322) 813 136.7 1.1e-31 >>CCDS47026.1 CC2D2A gene_id:57545|Hs108|chr4 (1620 aa) initn: 7748 init1: 7608 opt: 7608 Z-score: 6278.4 bits: 1174.5 E(32554): 0 Smith-Waterman score: 9800; 96.2% identity (96.2% similar) in 1544 aa overlap (1-1485:50-1593) 10 20 30 pF1KSD MVSEKSHLGNPQEPVQEEPKTRLLSMTVRR :::::::::::::::::::::::::::::: CCDS47 EDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNPQEPVQEEPKTRLLSMTVRR 20 30 40 50 60 70 40 50 60 70 80 90 pF1KSD GPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 GPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKEL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KSD ETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 ETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNF 140 150 160 170 180 190 160 170 180 190 200 210 pF1KSD DPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 DPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDH 200 210 220 230 240 250 220 230 240 250 260 270 pF1KSD VADDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 VADDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVR 260 270 280 290 300 310 280 290 300 310 320 330 pF1KSD PEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 PEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELET 320 330 340 350 360 370 340 350 360 370 380 390 pF1KSD LYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 LYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYL 380 390 400 410 420 430 400 410 420 430 440 450 pF1KSD ARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 ARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQ 440 450 460 470 480 490 460 470 480 490 500 510 pF1KSD EKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 EKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISEL 500 510 520 530 540 550 520 530 540 550 560 570 pF1KSD LEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 LEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKP 560 570 580 590 600 610 580 590 600 610 620 630 pF1KSD SPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 SPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKK 620 630 640 650 660 670 640 650 660 670 680 690 pF1KSD RSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESLTLQVYETVGHSSPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 RSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESLTLQVYETVGHSSPTL 680 690 700 710 720 730 700 710 720 730 740 750 pF1KSD LAEVFLPIPETTVVTGRAPTEEVEFSSNQHVTLDHEGVGSGVPFSFEADGSNQLTLMTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 LAEVFLPIPETTVVTGRAPTEEVEFSSNQHVTLDHEGVGSGVPFSFEADGSNQLTLMTSG 740 750 760 770 780 790 760 770 780 790 800 810 pF1KSD KVSHSVAWAIGENGIPLIPPLSQQNIGFRSALKKADAISSIGTSGLTDMKKLAKWAAESK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 KVSHSVAWAIGENGIPLIPPLSQQNIGFRSALKKADAISSIGTSGLTDMKKLAKWAAESK 800 810 820 830 840 850 820 830 840 850 860 870 pF1KSD LDPNDPNNAPLMQLISVATSGESYVPDFFRLEQLQQEFNFVSDQELNRSKRFRLLHLRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 LDPNDPNNAPLMQLISVATSGESYVPDFFRLEQLQQEFNFVSDQELNRSKRFRLLHLRSQ 860 870 880 890 900 910 880 890 900 910 920 930 pF1KSD EVPEFRNYKQVPVYDREIMEKVFQDYEKRLRDRNVIETKEHIDTHRAIVAKYLQQVRESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 EVPEFRNYKQVPVYDREIMEKVFQDYEKRLRDRNVIETKEHIDTHRAIVAKYLQQVRESV 920 930 940 950 960 970 940 950 960 970 980 990 pF1KSD INRFLIAKQYFLLADMIVEEEVPNISILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 INRFLIAKQYFLLADMIVEEEVPNISILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDG 980 990 1000 1010 1020 1030 1000 1010 1020 1030 1040 1050 pF1KSD DIKLLVNIVRAYDIPVRKPAVSKFQQPSRSSRMFSEKHAASPSTYSPTHNADYPLGQVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 DIKLLVNIVRAYDIPVRKPAVSKFQQPSRSSRMFSEKHAASPSTYSPTHNADYPLGQVLV 1040 1050 1060 1070 1080 1090 1060 1070 1080 1090 1100 1110 pF1KSD RPFVEVSFQRTVCHTTTAEGPNPSWNEELELPFRAPNGDYSTASLQSVKDVVFINIFDEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 RPFVEVSFQRTVCHTTTAEGPNPSWNEELELPFRAPNGDYSTASLQSVKDVVFINIFDEV 1100 1110 1120 1130 1140 1150 1120 1130 1140 pF1KSD LHDVLEDDRERGSGIHTRIERHWLGCVKMPFSTIYFQAR--------------------- ::::::::::::::::::::::::::::::::::::::: CCDS47 LHDVLEDDRERGSGIHTRIERHWLGCVKMPFSTIYFQARIDGTFKIDIPPVLLGYSKERN 1160 1170 1180 1190 1200 1210 1150 1160 1170 pF1KSD --------------------------------------FESQEDEKLLQATEKFQAECAL :::::::::::::::::::::: CCDS47 MILERGFDSVRSLSEGSYITLFITIEPQLVPGESIREKFESQEDEKLLQATEKFQAECAL 1220 1230 1240 1250 1260 1270 1180 1190 1200 1210 1220 1230 pF1KSD KFPNRQCLTTVIDISGKTVFITRYLKPLNPPQELLNVYPNNLQATAELVARYVSLIPFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 KFPNRQCLTTVIDISGKTVFITRYLKPLNPPQELLNVYPNNLQATAELVARYVSLIPFLP 1280 1290 1300 1310 1320 1330 1240 1250 1260 1270 1280 1290 pF1KSD DTVSFGGICDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSLGKKAWLLMGNAIPEGPTAYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 DTVSFGGICDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSLGKKAWLLMGNAIPEGPTAYV 1340 1350 1360 1370 1380 1390 1300 1310 1320 1330 1340 1350 pF1KSD LTWEQGRYLIWNPCSGHFYGQFDTFCPLKNVGCLIGPDNIWFNIQRYESPLRINFDVTRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 LTWEQGRYLIWNPCSGHFYGQFDTFCPLKNVGCLIGPDNIWFNIQRYESPLRINFDVTRP 1400 1410 1420 1430 1440 1450 1360 1370 1380 1390 1400 1410 pF1KSD KLWKSFFSRSLPYPGLSSVQPEELIYQRSDKAAAAELQDRIEKILKEKIMDWRPRHLTRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 KLWKSFFSRSLPYPGLSSVQPEELIYQRSDKAAAAELQDRIEKILKEKIMDWRPRHLTRW 1460 1470 1480 1490 1500 1510 1420 1430 1440 1450 1460 1470 pF1KSD NRYCTSTLRHFLPLLEKSQGEDVEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLIDAVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 NRYCTSTLRHFLPLLEKSQGEDVEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLIDAVY 1520 1530 1540 1550 1560 1570 1480 1490 1500 1510 pF1KSD STGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRNR :::::::::::::: CCDS47 STGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRNR 1580 1590 1600 1610 1620 >>CCDS53560.1 CC2D2B gene_id:387707|Hs108|chr10 (401 aa) initn: 1322 init1: 1245 opt: 1339 Z-score: 1114.9 bits: 217.1 E(32554): 8.9e-56 Smith-Waterman score: 1339; 46.3% identity (77.3% similar) in 397 aa overlap (1116-1512:7-401) 1090 1100 1110 1120 1130 1140 pF1KSD PNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMPFSTIY :: .. . :. :...::::. .:::.. CCDS53 MMTEKHEDHCLKSCSGHSYIRKNWLGCIVFPFSALL 10 20 30 1150 1160 1170 1180 1190 1200 pF1KSD FQARFESQEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNPPQEL :..: .: . .:: .. :. .: ::::. .:::.. : ..:::.: :::::.: CCDS53 QQSEFLDQTE--VLQRAQIFKKNCKAMFPNRRIVTTVFNDEGIQFLVTRYIKALNPPQQL 40 50 60 70 80 90 1210 1220 1230 1240 1250 1260 pF1KSD LNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHAVLLC :... .: .:: .:.::.::::::.:.: . . :.: ::.. ..: :..::::.::: CCDS53 LDIFLHNSNATFDLIARFVSLIPFVPNTPDENDGSDIWMTSEHCISLAIGNKEEHAILLC 100 110 120 130 140 150 1270 1280 1290 1300 1310 1320 pF1KSD NYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKNVGCL :.:: .:::: .:.:... :: .:::.: : ..::.::: .:. : ::: :::::.: :: CCDS53 NFFLYFGKKALVLLGTSVLEGHVAYVVTQETNEYLLWNPSTGQCYKQFDPFCPLKSVDCL 160 170 180 190 200 210 1330 1340 1350 1360 1370 1380 pF1KSD IGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSDKAAA . :.:::::. ..:. . :: .. ..::... ... ..:.::::.:: ..::. . CCDS53 FDDRNVWFNIQQNNTPMAVFFDYSKESFWKQLLPKNVQGTKIQSIQPEEIIYFETDKSMV 220 230 240 250 260 270 1390 1400 1410 1420 1430 1440 pF1KSD AELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAELLKQ .:..:::. :: :.:.:::.: :.::: :: ::..:: :: . : : .. :. . CCDS53 EDLRNRIERTLKSKVMEWRPKHPTHWNRQCTFILRQILPKLEFGIGSFVSSEGDNEFERI 280 290 300 310 320 330 1450 1460 1470 1480 1490 1500 pF1KSD LGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYV : : .:::..::: .:. .:::::.::.:. . :..::::::::::::.:.::::.:. CCDS53 LQFYWVTGFPIQMPYIDVQSIIDAVYQTGIHSAEFPQTEFALAVYIHPYPNNILSVWVYL 340 350 360 370 380 390 1510 pF1KSD ASLIRNR :::.... CCDS53 ASLVQHQ 400 >>CCDS41555.1 CC2D2B gene_id:387707|Hs108|chr10 (322 aa) initn: 1062 init1: 708 opt: 813 Z-score: 682.3 bits: 136.7 E(32554): 1.1e-31 Smith-Waterman score: 937; 37.3% identity (63.2% similar) in 397 aa overlap (1116-1512:7-322) 1090 1100 1110 1120 1130 1140 pF1KSD PNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMPFSTIY :: .. . :. :...::::. .:::.. CCDS41 MMTEKHEDHCLKSCSGHSYIRKNWLGCIVFPFSALL 10 20 30 1150 1160 1170 1180 1190 1200 pF1KSD FQARFESQEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNPPQEL :..: .: . .:: .. :. .: ::::. .:::.. : ..:::.: :::::.: CCDS41 QQSEFLDQTE--VLQRAQIFKKNCKAMFPNRRIVTTVFNDEGIQFLVTRYIKALNPPQQL 40 50 60 70 80 90 1210 1220 1230 1240 1250 1260 pF1KSD LNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHAVLLC :... .: .:: .:.::.::::::.:.: . . :.: ::.. ..: :..::::.::: CCDS41 LDIFLHNSNATFDLIARFVSLIPFVPNTPDENDGSDIWMTSEHCISLAIGNKEEHAILLC 100 110 120 130 140 150 1270 1280 1290 1300 1310 1320 pF1KSD NYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKNVGCL :.:: .:::: .:.:... :: .:::.: : ..::.::: .:. : ::: :::::.: :: CCDS41 NFFLYFGKKALVLLGTSVLEGHVAYVVTQETNEYLLWNPSTGQCYKQFDPFCPLKSVDCL 160 170 180 190 200 210 1330 1340 1350 1360 1370 1380 pF1KSD IGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSDKAAA . :.:::::. ..:. . :: .. ..::... ... ..:.: CCDS41 FDDRNVWFNIQQNNTPMAVFFDYSKESFWKQLLPKNVQGTKIQSIQ-------------- 220 230 240 250 260 1390 1400 1410 1420 1430 1440 pF1KSD AELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAELLKQ CCDS41 ------------------------------------------------------------ 1450 1460 1470 1480 1490 1500 pF1KSD LGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYV .:::..::: .:. .:::::.::.:. . :..::::::::::::.:.::::.:. CCDS41 -----VTGFPIQMPYIDVQSIIDAVYQTGIHSAEFPQTEFALAVYIHPYPNNILSVWVYL 270 280 290 300 310 1510 pF1KSD ASLIRNR :::.... CCDS41 ASLVQHQ 320 1512 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 05:54:49 2016 done: Thu Nov 3 05:54:50 2016 Total Scan time: 4.930 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]