FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1345, 1512 aa 1>>>pF1KSDA1345 1512 - 1512 aa - 1512 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.0413+/-0.00043; mu= 11.1429+/- 0.027 mean_var=165.3717+/-31.997, 0's: 0 Z-trim(115.6): 28 B-trim: 0 in 0/56 Lambda= 0.099734 statistics sampled from 26209 (26233) to 26209 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.652), E-opt: 0.2 (0.308), width: 16 Scan time: 18.060 The best scores are: opt bits E(85289) XP_016863971 (OMIM: 216360,612013,612284,612285) P (1571) 7608 1108.3 0 XP_005248234 (OMIM: 216360,612013,612284,612285) P (1620) 7608 1108.3 0 NP_001073991 (OMIM: 216360,612013,612284,612285) c (1620) 7608 1108.3 0 XP_011512174 (OMIM: 216360,612013,612284,612285) P (1013) 6317 922.4 0 NP_001158192 (OMIM: 216360,612013,612284,612285) c ( 111) 220 44.5 0.00058 XP_011512176 (OMIM: 216360,612013,612284,612285) P ( 111) 220 44.5 0.00058 >>XP_016863971 (OMIM: 216360,612013,612284,612285) PREDI (1571 aa) initn: 7748 init1: 7608 opt: 7608 Z-score: 5920.7 bits: 1108.3 E(85289): 0 Smith-Waterman score: 9800; 96.2% identity (96.2% similar) in 1544 aa overlap (1-1485:1-1544) 10 20 30 40 50 60 pF1KSD MVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD AARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD DSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD PPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD SRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD ILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDID 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD ISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD PHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD LKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD AKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHF 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD GQIFNLQIVNWPESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQIFNLQIVNWPESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQH 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD VTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD ALKKADAISSIGTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALKKADAISSIGTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFR 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD LEQLQQEFNFVSDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEQLQQEFNFVSDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRL 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD RDRNVIETKEHIDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDRNVIETKEHIDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGL 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD SLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRS 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD SRMFSEKHAASPSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRMFSEKHAASPSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELE 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD LPFRAPNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPFRAPNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMP 1090 1100 1110 1120 1130 1140 pF1KSD FSTIYFQAR--------------------------------------------------- ::::::::: XP_016 FSTIYFQARIDGTFKIDIPPVLLGYSKERNMILERGFDSVRSLSEGSYITLFITIEPQLV 1150 1160 1170 1180 1190 1200 1150 1160 1170 1180 1190 1200 pF1KSD --------FESQEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNP :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGESIREKFESQEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNP 1210 1220 1230 1240 1250 1260 1210 1220 1230 1240 1250 1260 pF1KSD PQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHA 1270 1280 1290 1300 1310 1320 1270 1280 1290 1300 1310 1320 pF1KSD VLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKN 1330 1340 1350 1360 1370 1380 1330 1340 1350 1360 1370 1380 pF1KSD VGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSD 1390 1400 1410 1420 1430 1440 1390 1400 1410 1420 1430 1440 pF1KSD KAAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAE 1450 1460 1470 1480 1490 1500 1450 1460 1470 1480 1490 1500 pF1KSD LLKQLGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSV :::::::::::::::::::::::::::::::::::::::::::: XP_016 LLKQLGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSV 1510 1520 1530 1540 1550 1560 1510 pF1KSD WIYVASLIRNR XP_016 WIYVASLIRNR 1570 >>XP_005248234 (OMIM: 216360,612013,612284,612285) PREDI (1620 aa) initn: 7748 init1: 7608 opt: 7608 Z-score: 5920.5 bits: 1108.3 E(85289): 0 Smith-Waterman score: 9800; 96.2% identity (96.2% similar) in 1544 aa overlap (1-1485:50-1593) 10 20 30 pF1KSD MVSEKSHLGNPQEPVQEEPKTRLLSMTVRR :::::::::::::::::::::::::::::: XP_005 EDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNPQEPVQEEPKTRLLSMTVRR 20 30 40 50 60 70 40 50 60 70 80 90 pF1KSD GPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKEL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KSD ETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNF 140 150 160 170 180 190 160 170 180 190 200 210 pF1KSD DPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDH 200 210 220 230 240 250 220 230 240 250 260 270 pF1KSD VADDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VADDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVR 260 270 280 290 300 310 280 290 300 310 320 330 pF1KSD PEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELET 320 330 340 350 360 370 340 350 360 370 380 390 pF1KSD LYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYL 380 390 400 410 420 430 400 410 420 430 440 450 pF1KSD ARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQ 440 450 460 470 480 490 460 470 480 490 500 510 pF1KSD EKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISEL 500 510 520 530 540 550 520 530 540 550 560 570 pF1KSD LEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKP 560 570 580 590 600 610 580 590 600 610 620 630 pF1KSD SPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKK 620 630 640 650 660 670 640 650 660 670 680 690 pF1KSD RSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESLTLQVYETVGHSSPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESLTLQVYETVGHSSPTL 680 690 700 710 720 730 700 710 720 730 740 750 pF1KSD LAEVFLPIPETTVVTGRAPTEEVEFSSNQHVTLDHEGVGSGVPFSFEADGSNQLTLMTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LAEVFLPIPETTVVTGRAPTEEVEFSSNQHVTLDHEGVGSGVPFSFEADGSNQLTLMTSG 740 750 760 770 780 790 760 770 780 790 800 810 pF1KSD KVSHSVAWAIGENGIPLIPPLSQQNIGFRSALKKADAISSIGTSGLTDMKKLAKWAAESK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KVSHSVAWAIGENGIPLIPPLSQQNIGFRSALKKADAISSIGTSGLTDMKKLAKWAAESK 800 810 820 830 840 850 820 830 840 850 860 870 pF1KSD LDPNDPNNAPLMQLISVATSGESYVPDFFRLEQLQQEFNFVSDQELNRSKRFRLLHLRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDPNDPNNAPLMQLISVATSGESYVPDFFRLEQLQQEFNFVSDQELNRSKRFRLLHLRSQ 860 870 880 890 900 910 880 890 900 910 920 930 pF1KSD EVPEFRNYKQVPVYDREIMEKVFQDYEKRLRDRNVIETKEHIDTHRAIVAKYLQQVRESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EVPEFRNYKQVPVYDREIMEKVFQDYEKRLRDRNVIETKEHIDTHRAIVAKYLQQVRESV 920 930 940 950 960 970 940 950 960 970 980 990 pF1KSD INRFLIAKQYFLLADMIVEEEVPNISILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 INRFLIAKQYFLLADMIVEEEVPNISILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDG 980 990 1000 1010 1020 1030 1000 1010 1020 1030 1040 1050 pF1KSD DIKLLVNIVRAYDIPVRKPAVSKFQQPSRSSRMFSEKHAASPSTYSPTHNADYPLGQVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DIKLLVNIVRAYDIPVRKPAVSKFQQPSRSSRMFSEKHAASPSTYSPTHNADYPLGQVLV 1040 1050 1060 1070 1080 1090 1060 1070 1080 1090 1100 1110 pF1KSD RPFVEVSFQRTVCHTTTAEGPNPSWNEELELPFRAPNGDYSTASLQSVKDVVFINIFDEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RPFVEVSFQRTVCHTTTAEGPNPSWNEELELPFRAPNGDYSTASLQSVKDVVFINIFDEV 1100 1110 1120 1130 1140 1150 1120 1130 1140 pF1KSD LHDVLEDDRERGSGIHTRIERHWLGCVKMPFSTIYFQAR--------------------- ::::::::::::::::::::::::::::::::::::::: XP_005 LHDVLEDDRERGSGIHTRIERHWLGCVKMPFSTIYFQARIDGTFKIDIPPVLLGYSKERN 1160 1170 1180 1190 1200 1210 1150 1160 1170 pF1KSD --------------------------------------FESQEDEKLLQATEKFQAECAL :::::::::::::::::::::: XP_005 MILERGFDSVRSLSEGSYITLFITIEPQLVPGESIREKFESQEDEKLLQATEKFQAECAL 1220 1230 1240 1250 1260 1270 1180 1190 1200 1210 1220 1230 pF1KSD KFPNRQCLTTVIDISGKTVFITRYLKPLNPPQELLNVYPNNLQATAELVARYVSLIPFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KFPNRQCLTTVIDISGKTVFITRYLKPLNPPQELLNVYPNNLQATAELVARYVSLIPFLP 1280 1290 1300 1310 1320 1330 1240 1250 1260 1270 1280 1290 pF1KSD DTVSFGGICDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSLGKKAWLLMGNAIPEGPTAYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DTVSFGGICDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSLGKKAWLLMGNAIPEGPTAYV 1340 1350 1360 1370 1380 1390 1300 1310 1320 1330 1340 1350 pF1KSD LTWEQGRYLIWNPCSGHFYGQFDTFCPLKNVGCLIGPDNIWFNIQRYESPLRINFDVTRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LTWEQGRYLIWNPCSGHFYGQFDTFCPLKNVGCLIGPDNIWFNIQRYESPLRINFDVTRP 1400 1410 1420 1430 1440 1450 1360 1370 1380 1390 1400 1410 pF1KSD KLWKSFFSRSLPYPGLSSVQPEELIYQRSDKAAAAELQDRIEKILKEKIMDWRPRHLTRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLWKSFFSRSLPYPGLSSVQPEELIYQRSDKAAAAELQDRIEKILKEKIMDWRPRHLTRW 1460 1470 1480 1490 1500 1510 1420 1430 1440 1450 1460 1470 pF1KSD NRYCTSTLRHFLPLLEKSQGEDVEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLIDAVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NRYCTSTLRHFLPLLEKSQGEDVEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLIDAVY 1520 1530 1540 1550 1560 1570 1480 1490 1500 1510 pF1KSD STGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRNR :::::::::::::: XP_005 STGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRNR 1580 1590 1600 1610 1620 >>NP_001073991 (OMIM: 216360,612013,612284,612285) coile (1620 aa) initn: 7748 init1: 7608 opt: 7608 Z-score: 5920.5 bits: 1108.3 E(85289): 0 Smith-Waterman score: 9800; 96.2% identity (96.2% similar) in 1544 aa overlap (1-1485:50-1593) 10 20 30 pF1KSD MVSEKSHLGNPQEPVQEEPKTRLLSMTVRR :::::::::::::::::::::::::::::: NP_001 EDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNPQEPVQEEPKTRLLSMTVRR 20 30 40 50 60 70 40 50 60 70 80 90 pF1KSD GPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKEL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KSD ETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNF 140 150 160 170 180 190 160 170 180 190 200 210 pF1KSD DPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDH 200 210 220 230 240 250 220 230 240 250 260 270 pF1KSD VADDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VADDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVR 260 270 280 290 300 310 280 290 300 310 320 330 pF1KSD PEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELET 320 330 340 350 360 370 340 350 360 370 380 390 pF1KSD LYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYL 380 390 400 410 420 430 400 410 420 430 440 450 pF1KSD ARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQ 440 450 460 470 480 490 460 470 480 490 500 510 pF1KSD EKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISEL 500 510 520 530 540 550 520 530 540 550 560 570 pF1KSD LEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKP 560 570 580 590 600 610 580 590 600 610 620 630 pF1KSD SPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKK 620 630 640 650 660 670 640 650 660 670 680 690 pF1KSD RSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESLTLQVYETVGHSSPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESLTLQVYETVGHSSPTL 680 690 700 710 720 730 700 710 720 730 740 750 pF1KSD LAEVFLPIPETTVVTGRAPTEEVEFSSNQHVTLDHEGVGSGVPFSFEADGSNQLTLMTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAEVFLPIPETTVVTGRAPTEEVEFSSNQHVTLDHEGVGSGVPFSFEADGSNQLTLMTSG 740 750 760 770 780 790 760 770 780 790 800 810 pF1KSD KVSHSVAWAIGENGIPLIPPLSQQNIGFRSALKKADAISSIGTSGLTDMKKLAKWAAESK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVSHSVAWAIGENGIPLIPPLSQQNIGFRSALKKADAISSIGTSGLTDMKKLAKWAAESK 800 810 820 830 840 850 820 830 840 850 860 870 pF1KSD LDPNDPNNAPLMQLISVATSGESYVPDFFRLEQLQQEFNFVSDQELNRSKRFRLLHLRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDPNDPNNAPLMQLISVATSGESYVPDFFRLEQLQQEFNFVSDQELNRSKRFRLLHLRSQ 860 870 880 890 900 910 880 890 900 910 920 930 pF1KSD EVPEFRNYKQVPVYDREIMEKVFQDYEKRLRDRNVIETKEHIDTHRAIVAKYLQQVRESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVPEFRNYKQVPVYDREIMEKVFQDYEKRLRDRNVIETKEHIDTHRAIVAKYLQQVRESV 920 930 940 950 960 970 940 950 960 970 980 990 pF1KSD INRFLIAKQYFLLADMIVEEEVPNISILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INRFLIAKQYFLLADMIVEEEVPNISILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDG 980 990 1000 1010 1020 1030 1000 1010 1020 1030 1040 1050 pF1KSD DIKLLVNIVRAYDIPVRKPAVSKFQQPSRSSRMFSEKHAASPSTYSPTHNADYPLGQVLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIKLLVNIVRAYDIPVRKPAVSKFQQPSRSSRMFSEKHAASPSTYSPTHNADYPLGQVLV 1040 1050 1060 1070 1080 1090 1060 1070 1080 1090 1100 1110 pF1KSD RPFVEVSFQRTVCHTTTAEGPNPSWNEELELPFRAPNGDYSTASLQSVKDVVFINIFDEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RPFVEVSFQRTVCHTTTAEGPNPSWNEELELPFRAPNGDYSTASLQSVKDVVFINIFDEV 1100 1110 1120 1130 1140 1150 1120 1130 1140 pF1KSD LHDVLEDDRERGSGIHTRIERHWLGCVKMPFSTIYFQAR--------------------- ::::::::::::::::::::::::::::::::::::::: NP_001 LHDVLEDDRERGSGIHTRIERHWLGCVKMPFSTIYFQARIDGTFKIDIPPVLLGYSKERN 1160 1170 1180 1190 1200 1210 1150 1160 1170 pF1KSD --------------------------------------FESQEDEKLLQATEKFQAECAL :::::::::::::::::::::: NP_001 MILERGFDSVRSLSEGSYITLFITIEPQLVPGESIREKFESQEDEKLLQATEKFQAECAL 1220 1230 1240 1250 1260 1270 1180 1190 1200 1210 1220 1230 pF1KSD KFPNRQCLTTVIDISGKTVFITRYLKPLNPPQELLNVYPNNLQATAELVARYVSLIPFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFPNRQCLTTVIDISGKTVFITRYLKPLNPPQELLNVYPNNLQATAELVARYVSLIPFLP 1280 1290 1300 1310 1320 1330 1240 1250 1260 1270 1280 1290 pF1KSD DTVSFGGICDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSLGKKAWLLMGNAIPEGPTAYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTVSFGGICDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSLGKKAWLLMGNAIPEGPTAYV 1340 1350 1360 1370 1380 1390 1300 1310 1320 1330 1340 1350 pF1KSD LTWEQGRYLIWNPCSGHFYGQFDTFCPLKNVGCLIGPDNIWFNIQRYESPLRINFDVTRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTWEQGRYLIWNPCSGHFYGQFDTFCPLKNVGCLIGPDNIWFNIQRYESPLRINFDVTRP 1400 1410 1420 1430 1440 1450 1360 1370 1380 1390 1400 1410 pF1KSD KLWKSFFSRSLPYPGLSSVQPEELIYQRSDKAAAAELQDRIEKILKEKIMDWRPRHLTRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLWKSFFSRSLPYPGLSSVQPEELIYQRSDKAAAAELQDRIEKILKEKIMDWRPRHLTRW 1460 1470 1480 1490 1500 1510 1420 1430 1440 1450 1460 1470 pF1KSD NRYCTSTLRHFLPLLEKSQGEDVEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLIDAVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRYCTSTLRHFLPLLEKSQGEDVEDDHRAELLKQLGDYRFSGFPLHMPYSEVKPLIDAVY 1520 1530 1540 1550 1560 1570 1480 1490 1500 1510 pF1KSD STGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRNR :::::::::::::: NP_001 STGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRNR 1580 1590 1600 1610 1620 >>XP_011512174 (OMIM: 216360,612013,612284,612285) PREDI (1013 aa) initn: 6545 init1: 6317 opt: 6317 Z-score: 4919.5 bits: 922.4 E(85289): 0 Smith-Waterman score: 6317; 99.7% identity (99.8% similar) in 960 aa overlap (1-960:50-1009) 10 20 30 pF1KSD MVSEKSHLGNPQEPVQEEPKTRLLSMTVRR :::::::::::::::::::::::::::::: XP_011 EDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNPQEPVQEEPKTRLLSMTVRR 20 30 40 50 60 70 40 50 60 70 80 90 pF1KSD GPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKEL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KSD ETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNF 140 150 160 170 180 190 160 170 180 190 200 210 pF1KSD DPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDH 200 210 220 230 240 250 220 230 240 250 260 270 pF1KSD VADDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VADDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVR 260 270 280 290 300 310 280 290 300 310 320 330 pF1KSD PEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELET 320 330 340 350 360 370 340 350 360 370 380 390 pF1KSD LYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYL 380 390 400 410 420 430 400 410 420 430 440 450 pF1KSD ARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQ 440 450 460 470 480 490 460 470 480 490 500 510 pF1KSD EKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISEL 500 510 520 530 540 550 520 530 540 550 560 570 pF1KSD LEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKP 560 570 580 590 600 610 580 590 600 610 620 630 pF1KSD SPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKK 620 630 640 650 660 670 640 650 660 670 680 690 pF1KSD RSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESLTLQVYETVGHSSPTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESLTLQVYETVGHSSPTL 680 690 700 710 720 730 700 710 720 730 740 750 pF1KSD LAEVFLPIPETTVVTGRAPTEEVEFSSNQHVTLDHEGVGSGVPFSFEADGSNQLTLMTSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAEVFLPIPETTVVTGRAPTEEVEFSSNQHVTLDHEGVGSGVPFSFEADGSNQLTLMTSG 740 750 760 770 780 790 760 770 780 790 800 810 pF1KSD KVSHSVAWAIGENGIPLIPPLSQQNIGFRSALKKADAISSIGTSGLTDMKKLAKWAAESK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVSHSVAWAIGENGIPLIPPLSQQNIGFRSALKKADAISSIGTSGLTDMKKLAKWAAESK 800 810 820 830 840 850 820 830 840 850 860 870 pF1KSD LDPNDPNNAPLMQLISVATSGESYVPDFFRLEQLQQEFNFVSDQELNRSKRFRLLHLRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDPNDPNNAPLMQLISVATSGESYVPDFFRLEQLQQEFNFVSDQELNRSKRFRLLHLRSQ 860 870 880 890 900 910 880 890 900 910 920 930 pF1KSD EVPEFRNYKQVPVYDREIMEKVFQDYEKRLRDRNVIETKEHIDTHRAIVAKYLQQVRESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVPEFRNYKQVPVYDREIMEKVFQDYEKRLRDRNVIETKEHIDTHRAIVAKYLQQVRESV 920 930 940 950 960 970 940 950 960 970 980 990 pF1KSD INRFLIAKQYFLLADMIVEEEVPNISILGLSLFKLAEQKRPLRPRRKGRKKVTAQNLSDG ::::::::::::::::::::::::: .: : XP_011 INRFLIAKQYFLLADMIVEEEVPNIRVLILFCNH 980 990 1000 1010 >>NP_001158192 (OMIM: 216360,612013,612284,612285) coile (111 aa) initn: 243 init1: 220 opt: 220 Z-score: 192.2 bits: 44.5 E(85289): 0.00058 Smith-Waterman score: 220; 100.0% identity (100.0% similar) in 33 aa overlap (1-33:50-82) 10 20 30 pF1KSD MVSEKSHLGNPQEPVQEEPKTRLLSMTVRR :::::::::::::::::::::::::::::: NP_001 EDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNPQEPVQEEPKTRLLSMTVRR 20 30 40 50 60 70 40 50 60 70 80 90 pF1KSD GPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKEL ::: NP_001 GPRRELVVKKSLGRPGTVTHVCNPSTLEGRGG 80 90 100 110 >>XP_011512176 (OMIM: 216360,612013,612284,612285) PREDI (111 aa) initn: 243 init1: 220 opt: 220 Z-score: 192.2 bits: 44.5 E(85289): 0.00058 Smith-Waterman score: 220; 100.0% identity (100.0% similar) in 33 aa overlap (1-33:50-82) 10 20 30 pF1KSD MVSEKSHLGNPQEPVQEEPKTRLLSMTVRR :::::::::::::::::::::::::::::: XP_011 EDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNPQEPVQEEPKTRLLSMTVRR 20 30 40 50 60 70 40 50 60 70 80 90 pF1KSD GPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKEL ::: XP_011 GPRRELVVKKSLGRPGTVTHVCNPSTLEGRGG 80 90 100 110 1512 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 05:54:50 2016 done: Thu Nov 3 05:54:53 2016 Total Scan time: 18.060 Total Display time: 0.300 Function used was FASTA [36.3.4 Apr, 2011]