FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1399, 410 aa 1>>>pF1KSDA1399 410 - 410 aa - 410 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.4725+/-0.000334; mu= 0.2724+/- 0.021 mean_var=280.0599+/-57.827, 0's: 0 Z-trim(124.8): 34 B-trim: 480 in 1/58 Lambda= 0.076639 statistics sampled from 47100 (47136) to 47100 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.822), E-opt: 0.2 (0.553), width: 16 Scan time: 7.630 The best scores are: opt bits E(85289) NP_065865 (OMIM: 608208) E3 ubiquitin-protein liga ( 410) 3001 344.5 2.8e-94 NP_612405 (OMIM: 613336) E3 ubiquitin-protein liga ( 346) 1194 144.7 3.4e-34 NP_001096032 (OMIM: 613338) E3 ubiquitin-protein l ( 402) 975 120.5 7.4e-27 NP_001159845 (OMIM: 613331) E3 ubiquitin-protein l ( 289) 279 43.4 0.00086 XP_016863823 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 289) 279 43.4 0.00086 XP_016863824 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 285) 273 42.8 0.0013 XP_016863825 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 285) 273 42.8 0.0013 NP_060393 (OMIM: 613331) E3 ubiquitin-protein liga ( 272) 268 42.2 0.0019 XP_011530357 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 545) 266 42.2 0.0037 XP_011537797 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 291) 259 41.2 0.004 XP_016871383 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 291) 259 41.2 0.004 NP_001002266 (OMIM: 613335) E3 ubiquitin-protein l ( 291) 259 41.2 0.004 NP_659458 (OMIM: 613335) E3 ubiquitin-protein liga ( 291) 259 41.2 0.004 XP_011537794 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 260 41.6 0.006 XP_011537796 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 260 41.6 0.006 XP_011537795 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 260 41.6 0.006 NP_001269795 (OMIM: 613335) E3 ubiquitin-protein l ( 573) 260 41.6 0.006 XP_005271861 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 260 41.6 0.006 XP_006717767 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573) 260 41.6 0.006 >>NP_065865 (OMIM: 608208) E3 ubiquitin-protein ligase M (410 aa) initn: 3001 init1: 3001 opt: 3001 Z-score: 1813.7 bits: 344.5 E(85289): 2.8e-94 Smith-Waterman score: 3001; 100.0% identity (100.0% similar) in 410 aa overlap (1-410:1-410) 10 20 30 40 50 60 pF1KSD MLMPLCGLLWWWWCCCSGWYCYGLCAPAPQMLRHQGLLKCRCRMLFNDLKVFLLRRPPQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MLMPLCGLLWWWWCCCSGWYCYGLCAPAPQMLRHQGLLKCRCRMLFNDLKVFLLRRPPQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD PLPMHGDPQPPGLAANNTLPALGAGGWAGWRGPREVVGREPPPVPPPPPLPPSSVEDDWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 PLPMHGDPQPPGLAANNTLPALGAGGWAGWRGPREVVGREPPPVPPPPPLPPSSVEDDWG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD GPATEPPASLLSSASSDDFCKEKTEDRYSLGSSLDSGMRTPLCRICFQGPEQGELLSPCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GPATEPPASLLSSASSDDFCKEKTEDRYSLGSSLDSGMRTPLCRICFQGPEQGELLSPCR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD CDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAISTKNPLQWQAISLTVIEKVQVAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 CDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAISTKNPLQWQAISLTVIEKVQVAA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD AILGSLFLIASISWLIWSTFSPSARWQRQDLLFQICYGMYGFMDVVCIGLIIHEGPSVYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 AILGSLFLIASISWLIWSTFSPSARWQRQDLLFQICYGMYGFMDVVCIGLIIHEGPSVYR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD IFKRWQAVNQQWKVLNYDKTKDLEDQKAGGRTNPRTSSSTQANIPSSEEETAGTPAPEQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 IFKRWQAVNQQWKVLNYDKTKDLEDQKAGGRTNPRTSSSTQANIPSSEEETAGTPAPEQG 310 320 330 340 350 360 370 380 390 400 410 pF1KSD PAQAAGHPSGPLSHHHCAYTILHILSHLRPHEQRSPPGSSRELVMRVTTV :::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 PAQAAGHPSGPLSHHHCAYTILHILSHLRPHEQRSPPGSSRELVMRVTTV 370 380 390 400 410 >>NP_612405 (OMIM: 613336) E3 ubiquitin-protein ligase M (346 aa) initn: 1393 init1: 1174 opt: 1194 Z-score: 734.8 bits: 144.7 E(85289): 3.4e-34 Smith-Waterman score: 1367; 58.3% identity (70.7% similar) in 386 aa overlap (37-410:1-346) 10 20 30 40 50 60 pF1KSD GLLWWWWCCCSGWYCYGLCAPAPQMLRHQGLLKCRCRMLFNDLKVFLLR---RPPQAPLP .:: : ::..:.::...: :: : : NP_612 MLKSRLRMFLNELKLLVLTGGGRPRAEPQP 10 20 30 70 80 90 100 110 pF1KSD MHGDPQPPGLAA-NNTLPALGAGGWAGWRG--PRE--VVG-REPPPVPPPPPLPPSSVED : : : . : : . : :: ..: .:: : ::: :: NP_612 RGGRGGGCGWAPFAGCSTRDGDGDEEEYYGSEPRARGLAGDKEPRAGPLPPPAPP----- 40 50 60 70 80 120 130 140 150 160 170 pF1KSD DWGGPATEPPASLLSSASSDDFCKEKTEDRYSLGSSLDSGMRTPLCRICFQGPEQGELLS ::..: : ::.::::::.::: ::::::::::::::: NP_612 ------LPPPGAL---------------DALSLSSSLDSGLRTPQCRICFQGPEQGELLS 90 100 110 120 180 190 200 210 220 230 pF1KSD PCRCDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAISTKNPLQWQAISLTVIEKVQ ::::::::.::::::::.:::::: :::::::.::.:.:::::::::::::::::::::: NP_612 PCRCDGSVRCTHQPCLIRWISERGSWSCELCYFKYQVLAISTKNPLQWQAISLTVIEKVQ 130 140 150 160 170 180 240 250 260 270 280 290 pF1KSD VAAAILGSLFLIASISWLIWSTFSPSARWQRQDLLFQICYGMYGFMDVVCIGLIIHEGPS .:: .::::::.:::::::::..::::.:::::::::::::::::::::::::::::: : NP_612 IAAIVLGSLFLVASISWLIWSSLSPSAKWQRQDLLFQICYGMYGFMDVVCIGLIIHEGSS 190 200 210 220 230 240 300 310 320 330 340 350 pF1KSD VYRIFKRWQAVNQQWKVLNYDKTKDLEDQKAGG---RTNPRTSSSTQANIPSSEEETAGT :::::::::::::::::::::::::. . .:: ...::.: . :.: ..: NP_612 VYRIFKRWQAVNQQWKVLNYDKTKDIGGDAGGGTAGKSGPRNSRTG----PTS----GAT 250 260 270 280 290 360 370 380 390 400 410 pF1KSD PAPEQGPAQAAGHPSGPLSHHHCAYTILHILSHLRPHEQRSPPGSSRELVMRVTTV : :: . : ..:.:::::.:..::: . :: :.::.::::::: NP_612 SRP---PAAQRMRTLLP---QRCGYTILHLLGQLRPPDARSSSHSGREVVMRVTTV 300 310 320 330 340 >>NP_001096032 (OMIM: 613338) E3 ubiquitin-protein ligas (402 aa) initn: 1124 init1: 958 opt: 975 Z-score: 603.1 bits: 120.5 E(85289): 7.4e-27 Smith-Waterman score: 1122; 47.2% identity (66.8% similar) in 392 aa overlap (57-410:28-402) 30 40 50 60 70 80 pF1KSD PAPQMLRHQGLLKCRCRMLFNDLKVFLLRRPPQAPLPMHGDPQP-PGLAANNTLPALGAG :: : : :.: : : :: :: : :. NP_001 MSFEGGHGGSRCRGAESGDAEPPPQPPPPPPPTPPPGEPAPVP--AAPRYLPPLPAS 10 20 30 40 50 90 100 110 120 130 pF1KSD GWAGWR--GPREVVGREPP------PVPPPP-PLPPSSVE-----DDWGGPATEPPASLL . : :: : .:. : .:::: :: :.. : :. :: : :. NP_001 PETPERAAGPSEPLGEVAPRCRGADELPPPPLPLQPAGQEVAAAGDSGEGPRRLPEAAAA 60 70 80 90 100 110 140 150 160 pF1KSD SSASSDDFCKEKTE-DRYSLGS-----------SLDSG-----------MRTPLCRICFQ ... ... : .: . :. : .:: . :.:.:::: NP_001 KGGPGESEAGAGGERERRGAGDQPETRSVCSSRSSSSGGGDQRAGHQHQHHQPICKICFQ 120 130 140 150 160 170 170 180 190 200 210 220 pF1KSD GPEQGELLSPCRCDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAISTKNPLQWQAI : ::::::.::::::::. ::: ::.::::::: :.:::: :.::::::. :.: :::.: NP_001 GAEQGELLNPCRCDGSVRYTHQLCLLKWISERGSWTCELCCYRYHVIAIKMKQPCQWQSI 180 190 200 210 220 230 230 240 250 260 270 280 pF1KSD SLTVIEKVQVAAAILGSLFLIASISWLIWSTFSPSARWQRQDLLFQICYGMYGFMDVVCI :.:..::::. :.::::::::::..::.::.::: : :::.:.:::::::::::::.::: NP_001 SITLVEKVQMIAVILGSLFLIASVTWLLWSAFSPYAVWQRKDILFQICYGMYGFMDLVCI 240 250 260 270 280 290 290 300 310 320 330 340 pF1KSD GLIIHEGPSVYRIFKRWQAVNQQWKVLNYDKTKDLEDQKAGGRTNPRTSSSTQANIPSSE :::.::: .:::.::::.::: .: ::::::. :.:... : ..:.: .: . NP_001 GLIVHEGAAVYRVFKRWRAVNLHWDVLNYDKATDIEESSRG-----ESSTSRTLWLPLTA 300 310 320 330 340 350 350 360 370 380 390 400 pF1KSD EETAGTPAPEQGPAQAAGHPSGPLSHHHCAYTILHILSHLRPHEQRSPPGSSRELVMRVT .. . : : ..: . .:.:..::.....::::. : .:: :.::::: NP_001 LRNRNLVHPTQL--------TSP--RFQCGYVLLHLFNRMRPHEDLSEDNSSGEVVMRVT 360 370 380 390 400 410 pF1KSD TV .: NP_001 SV >>NP_001159845 (OMIM: 613331) E3 ubiquitin-protein ligas (289 aa) initn: 169 init1: 169 opt: 279 Z-score: 189.1 bits: 43.4 E(85289): 0.00086 Smith-Waterman score: 279; 25.4% identity (52.6% similar) in 291 aa overlap (89-363:3-285) 60 70 80 90 100 110 pF1KSD QAPLPMHGDPQPPGLAANNTLPALGAGGWAGWRGPREVVGREPPPVPPPPPLPPSSVE-D :: :...:.: .: : : . NP_001 MLGWC---EAIARNPHRIPNNTRTPEISGDLA 10 20 120 130 140 150 160 170 pF1KSD DWGGPATEPPASLLSSAS-SDDFCKEKTEDRYSLGSSLDSGMRTP----LCRICF-QGPE : . .: : ::: :... : .. . : . : .:::: .: : NP_001 DASQTSTLNEKSPGRSASRSSNISKASSPTTGTAPRSQSRLSVCPSTQDICRICHCEGDE 30 40 50 60 70 80 180 190 200 210 220 230 pF1KSD QGELLSPCRCDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAISTKNPL-QWQAISL .. :..:::: :... .:: :: .::. :::: :: : . .:: .:. ... NP_001 ESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELC--KYDFIMETKLKPLRKWEKLQM 90 100 110 120 130 140 240 250 260 270 280 pF1KSD TVIEKVQVAAAILGSLFLIASISWLIWSTFSPSARWQRQDLLFQIC-YGMYGFMDVVCIG :. :. .. .. .. :. . : .. .. .:. .: . . .. . :: :: NP_001 TTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIG 150 160 170 180 190 200 290 300 310 320 330 340 pF1KSD L-----IIHEGPSVY-RIFKRWQAVNQQWKVLNY-DKTKDLEDQKAGGRTNPRTSSSTQA . ... .:: ....: .: :. : : : .: :: . . : :. . . NP_001 FTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFS---CNVNTDIKDAV 210 220 230 240 250 260 350 360 370 380 390 400 pF1KSD NIPSSEEETAGTPAPEQGPAQAAGHPSGPLSHHHCAYTILHILSHLRPHEQRSPPGSSRE .: . . . :. : :: . NP_001 VVPVPQTGANSLPSAEGGPPEVVSV 270 280 >>XP_016863823 (OMIM: 613331) PREDICTED: E3 ubiquitin-pr (289 aa) initn: 169 init1: 169 opt: 279 Z-score: 189.1 bits: 43.4 E(85289): 0.00086 Smith-Waterman score: 279; 25.4% identity (52.6% similar) in 291 aa overlap (89-363:3-285) 60 70 80 90 100 110 pF1KSD QAPLPMHGDPQPPGLAANNTLPALGAGGWAGWRGPREVVGREPPPVPPPPPLPPSSVE-D :: :...:.: .: : : . XP_016 MLGWC---EAIARNPHRIPNNTRTPEISGDLA 10 20 120 130 140 150 160 170 pF1KSD DWGGPATEPPASLLSSAS-SDDFCKEKTEDRYSLGSSLDSGMRTP----LCRICF-QGPE : . .: : ::: :... : .. . : . : .:::: .: : XP_016 DASQTSTLNEKSPGRSASRSSNISKASSPTTGTAPRSQSRLSVCPSTQDICRICHCEGDE 30 40 50 60 70 80 180 190 200 210 220 230 pF1KSD QGELLSPCRCDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAISTKNPL-QWQAISL .. :..:::: :... .:: :: .::. :::: :: : . .:: .:. ... XP_016 ESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELC--KYDFIMETKLKPLRKWEKLQM 90 100 110 120 130 140 240 250 260 270 280 pF1KSD TVIEKVQVAAAILGSLFLIASISWLIWSTFSPSARWQRQDLLFQIC-YGMYGFMDVVCIG :. :. .. .. .. :. . : .. .. .:. .: . . .. . :: :: XP_016 TTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIG 150 160 170 180 190 200 290 300 310 320 330 340 pF1KSD L-----IIHEGPSVY-RIFKRWQAVNQQWKVLNY-DKTKDLEDQKAGGRTNPRTSSSTQA . ... .:: ....: .: :. : : : .: :: . . : :. . . XP_016 FTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFS---CNVNTDIKDAV 210 220 230 240 250 260 350 360 370 380 390 400 pF1KSD NIPSSEEETAGTPAPEQGPAQAAGHPSGPLSHHHCAYTILHILSHLRPHEQRSPPGSSRE .: . . . :. : :: . XP_016 VVPVPQTGANSLPSAEGGPPEVVSV 270 280 >>XP_016863824 (OMIM: 613331) PREDICTED: E3 ubiquitin-pr (285 aa) initn: 169 init1: 169 opt: 273 Z-score: 185.6 bits: 42.8 E(85289): 0.0013 Smith-Waterman score: 273; 25.4% identity (55.4% similar) in 260 aa overlap (115-363:32-281) 90 100 110 120 130 140 pF1KSD GGWAGWRGPREVVGREPPPVPPPPPLPPSSVEDDWGGPATEPPASLLSSASSDDF-CKEK ::.. . . .: .:.::: . XP_016 PLHQISVIPARETASNGRNSMGRNKEKNKEVENEKSPGRSASRSSNISKASSPTTGTAPR 10 20 30 40 50 60 150 160 170 180 190 200 pF1KSD TEDRYSLGSSLDSGMRTPLCRICF-QGPEQGELLSPCRCDGSVKCTHQPCLIKWISERGC ...: :. : .. .:::: .: :.. :..:::: :... .:: :: .::. XP_016 SQSRLSVCPSTQD-----ICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDT 70 80 90 100 110 210 220 230 240 250 260 pF1KSD WSCELCYYKYHVIAISTKNPL-QWQAISLTVIEKVQVAAAILGSLFLIASISWLIWSTFS :::: :: : . .:: .:. ...:. :. .. .. .. :. . : .. .. XP_016 RCCELC--KYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLID 120 130 140 150 160 170 270 280 290 300 310 pF1KSD PSARWQRQDLLFQIC-YGMYGFMDVVCIGL-----IIHEGPSVY-RIFKRWQAVNQQWKV .:. .: . . .. . :: ::. ... .:: ....: .: :. : XP_016 RTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFV 180 190 200 210 220 230 320 330 340 350 360 370 pF1KSD LNY-DKTKDLEDQKAGGRTNPRTSSSTQANIPSSEEETAGTPAPEQGPAQAAGHPSGPLS : : .: :: . . : :. . . .: . . . :. : :: . XP_016 QNCPDTAKKLEKNFS---CNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV 240 250 260 270 280 380 390 400 410 pF1KSD HHHCAYTILHILSHLRPHEQRSPPGSSRELVMRVTTV >>XP_016863825 (OMIM: 613331) PREDICTED: E3 ubiquitin-pr (285 aa) initn: 169 init1: 169 opt: 273 Z-score: 185.6 bits: 42.8 E(85289): 0.0013 Smith-Waterman score: 273; 25.4% identity (55.4% similar) in 260 aa overlap (115-363:32-281) 90 100 110 120 130 140 pF1KSD GGWAGWRGPREVVGREPPPVPPPPPLPPSSVEDDWGGPATEPPASLLSSASSDDF-CKEK ::.. . . .: .:.::: . XP_016 PLHQISVIPARETASNGRNSMGRNKEKNKEVENEKSPGRSASRSSNISKASSPTTGTAPR 10 20 30 40 50 60 150 160 170 180 190 200 pF1KSD TEDRYSLGSSLDSGMRTPLCRICF-QGPEQGELLSPCRCDGSVKCTHQPCLIKWISERGC ...: :. : .. .:::: .: :.. :..:::: :... .:: :: .::. XP_016 SQSRLSVCPSTQD-----ICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDT 70 80 90 100 110 210 220 230 240 250 260 pF1KSD WSCELCYYKYHVIAISTKNPL-QWQAISLTVIEKVQVAAAILGSLFLIASISWLIWSTFS :::: :: : . .:: .:. ...:. :. .. .. .. :. . : .. .. XP_016 RCCELC--KYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLID 120 130 140 150 160 170 270 280 290 300 310 pF1KSD PSARWQRQDLLFQIC-YGMYGFMDVVCIGL-----IIHEGPSVY-RIFKRWQAVNQQWKV .:. .: . . .. . :: ::. ... .:: ....: .: :. : XP_016 RTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFV 180 190 200 210 220 230 320 330 340 350 360 370 pF1KSD LNY-DKTKDLEDQKAGGRTNPRTSSSTQANIPSSEEETAGTPAPEQGPAQAAGHPSGPLS : : .: :: . . : :. . . .: . . . :. : :: . XP_016 QNCPDTAKKLEKNFS---CNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV 240 250 260 270 280 380 390 400 410 pF1KSD HHHCAYTILHILSHLRPHEQRSPPGSSRELVMRVTTV >>NP_060393 (OMIM: 613331) E3 ubiquitin-protein ligase M (272 aa) initn: 195 init1: 169 opt: 268 Z-score: 182.9 bits: 42.2 E(85289): 0.0019 Smith-Waterman score: 268; 25.0% identity (55.7% similar) in 244 aa overlap (130-363:35-268) 100 110 120 130 140 150 pF1KSD EPPPVPPPPPLPPSSVEDDWGGPATEPPASLLSSASSDDFCKEKTEDRYSLGSSLDSGMR .:...: ....: :. : .. NP_060 HVCCNFLNMWKKSKISTMYYLNQDAKLSNLFLQASSPTTGTAPRSQSRLSVCPSTQD--- 10 20 30 40 50 60 160 170 180 190 200 210 pF1KSD TPLCRICF-QGPEQGELLSPCRCDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAIS .:::: .: :.. :..:::: :... .:: :: .::. :::: :: : . NP_060 --ICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELC--KYDFIMET 70 80 90 100 110 220 230 240 250 260 270 pF1KSD TKNPL-QWQAISLTVIEKVQVAAAILGSLFLIASISWLIWSTFSPSARWQRQDLLFQIC- .:: .:. ...:. :. .. .. .. :. . : .. .. .:. .: . NP_060 KLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLE 120 130 140 150 160 170 280 290 300 310 320 pF1KSD YGMYGFMDVVCIGL-----IIHEGPSVY-RIFKRWQAVNQQWKVLNY-DKTKDLEDQKAG . .. . :: ::. ... .:: ....: .: :. : : : .: :: . . NP_060 WPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFS- 180 190 200 210 220 230 330 340 350 360 370 380 pF1KSD GRTNPRTSSSTQANIPSSEEETAGTPAPEQGPAQAAGHPSGPLSHHHCAYTILHILSHLR : :. . . .: . . . :. : :: . NP_060 --CNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV 240 250 260 270 390 400 410 pF1KSD PHEQRSPPGSSRELVMRVTTV >>XP_011530357 (OMIM: 613331) PREDICTED: E3 ubiquitin-pr (545 aa) initn: 194 init1: 169 opt: 266 Z-score: 177.7 bits: 42.2 E(85289): 0.0037 Smith-Waterman score: 266; 26.0% identity (56.2% similar) in 219 aa overlap (155-363:328-541) 130 140 150 160 170 180 pF1KSD EPPASLLSSASSDDFCKEKTEDRYSLGSSLDSGMRTPLCRICF-QGPEQGELLSPCRCDG :.. .:::: .: :.. :..:::: : XP_011 ILGVPEGSKDMNDAGLQVNNPVQKPPATYDDGSDNLEVCRICHCEGDEESPLITPCRCTG 300 310 320 330 340 350 190 200 210 220 230 240 pF1KSD SVKCTHQPCLIKWISERGCWSCELCYYKYHVIAISTKNPL-QWQAISLTVIEKVQVAAAI ... .:: :: .::. :::: :: : . .:: .:. ...:. :. .. .. XP_011 TLRFVHQSCLHQWIKSSDTRCCELC--KYDFIMETKLKPLRKWEKLQMTTSERRKIFCSV 360 370 380 390 400 410 250 260 270 280 290 pF1KSD LGSLFLIASISWLIWSTFSPSARWQRQDLLFQIC-YGMYGFMDVVCIGL-----IIHEGP .. :. . : .. .. .:. .: . . .. . :: ::. ... XP_011 TFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQC 420 430 440 450 460 470 300 310 320 330 340 350 pF1KSD SVY-RIFKRWQAVNQQWKVLNY-DKTKDLEDQKAGGRTNPRTSSSTQANIPSSEEETAGT .:: ....: .: :. : : : .: :: . . : :. . . .: . . . XP_011 KVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFS---CNVNTDIKDAVVVPVPQTGANSL 480 490 500 510 520 530 360 370 380 390 400 410 pF1KSD PAPEQGPAQAAGHPSGPLSHHHCAYTILHILSHLRPHEQRSPPGSSRELVMRVTTV :. : :: . XP_011 PSAEGGPPEVVSV 540 >>XP_011537797 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr (291 aa) initn: 161 init1: 161 opt: 259 Z-score: 177.1 bits: 41.2 E(85289): 0.004 Smith-Waterman score: 259; 26.1% identity (56.9% similar) in 211 aa overlap (162-363:79-287) 140 150 160 170 180 190 pF1KSD SSASSDDFCKEKTEDRYSLGSSLDSGMRTPLCRICF-QGPEQGELLSPCRCDGSVKCTHQ .:::: .: ... :..::.: ::.. .:: XP_011 ISKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQ 50 60 70 80 90 100 200 210 220 230 240 pF1KSD PCLIKWISERGCWSCELCYYKYHVIAISTKNPL-QWQAISLTVIEKVQVAAAILGSLFLI :: .::. :::: ::. : . .:: .:. ...: :. .. .. .. : XP_011 ACLQQWIKSSDTRCCELC--KYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAI 110 120 130 140 150 160 250 260 270 280 290 300 pF1KSD ASISWLIWSTFSPSARWQRQDLLFQIC-YGMYGFMDVVCIG-----LIIHEGPSVY-RIF . . : .. .. .:. .: : . .. . :: :: :... .:: ... XP_011 TCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLW 170 180 190 200 210 220 310 320 330 340 350 360 pF1KSD KRWQAVNQQWKVLNYDKTKDLEDQKAGGRTNPRTSSSTQANIPSSEEETAGTPAPEQGPA :: .: :. : : .:. . . . :.: .. .: :. ... ::. : XP_011 KRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGA 230 240 250 260 270 280 370 380 390 400 410 pF1KSD QAAGHPSGPLSHHHCAYTILHILSHLRPHEQRSPPGSSRELVMRVTTV . XP_011 EIIHV 290 410 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 06:08:38 2016 done: Thu Nov 3 06:08:39 2016 Total Scan time: 7.630 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]