FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1563, 1657 aa 1>>>pF1KSDA1563 1657 - 1657 aa - 1657 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4803+/-0.00046; mu= 17.5897+/- 0.029 mean_var=91.1776+/-18.740, 0's: 0 Z-trim(111.4): 164 B-trim: 68 in 2/50 Lambda= 0.134317 statistics sampled from 19742 (19939) to 19742 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.579), E-opt: 0.2 (0.234), width: 16 Scan time: 18.630 The best scores are: opt bits E(85289) NP_065970 (OMIM: 205100,606352,606353,607225) alsi (1657) 11064 2155.6 0 XP_006712717 (OMIM: 205100,606352,606353,607225) P (1657) 11064 2155.6 0 XP_016860058 (OMIM: 205100,606352,606353,607225) P (1656) 11038 2150.5 0 XP_011509832 (OMIM: 205100,606352,606353,607225) P (1544) 10306 2008.7 0 XP_016860059 (OMIM: 205100,606352,606353,607225) P (1342) 8942 1744.3 0 XP_006712718 (OMIM: 205100,606352,606353,607225) P ( 969) 6538 1278.4 0 XP_016860060 (OMIM: 205100,606352,606353,607225) P ( 968) 6512 1273.4 0 XP_016860061 (OMIM: 205100,606352,606353,607225) P ( 863) 5881 1151.1 0 NP_001129217 (OMIM: 205100,606352,606353,607225) a ( 396) 2456 487.3 1.2e-136 XP_016861609 (OMIM: 612402) PREDICTED: ALS2 C-term ( 752) 1213 246.5 6.6e-64 XP_006713154 (OMIM: 612402) PREDICTED: ALS2 C-term ( 753) 1212 246.3 7.6e-64 NP_667340 (OMIM: 612402) ALS2 C-terminal-like prot ( 953) 1213 246.6 8.1e-64 NP_001177636 (OMIM: 612402) ALS2 C-terminal-like p ( 953) 1213 246.6 8.1e-64 XP_006713157 (OMIM: 612402) PREDICTED: ALS2 C-term ( 521) 840 174.2 2.8e-42 XP_006713156 (OMIM: 612402) PREDICTED: ALS2 C-term ( 522) 560 119.9 5.9e-26 XP_011531874 (OMIM: 612402) PREDICTED: ALS2 C-term ( 530) 560 119.9 6e-26 XP_005265082 (OMIM: 612402) PREDICTED: ALS2 C-term ( 468) 524 112.9 6.8e-24 NP_001305434 (OMIM: 605200) probable E3 ubiquitin- ( 368) 298 69.1 8.4e-11 XP_005263389 (OMIM: 605200) PREDICTED: probable E3 ( 896) 298 69.2 1.8e-10 XP_005263388 (OMIM: 605200) PREDICTED: probable E3 ( 903) 298 69.2 1.8e-10 XP_005263387 (OMIM: 605200) PREDICTED: probable E3 ( 993) 298 69.3 2e-10 XP_016864295 (OMIM: 605200) PREDICTED: probable E3 (1042) 298 69.3 2.1e-10 XP_005263386 (OMIM: 605200) PREDICTED: probable E3 (1042) 298 69.3 2.1e-10 NP_055421 (OMIM: 605200) probable E3 ubiquitin-pro (1050) 298 69.3 2.1e-10 XP_005263384 (OMIM: 605200) PREDICTED: probable E3 (1050) 298 69.3 2.1e-10 XP_016878186 (OMIM: 176270,227220,605837,615516) P (2556) 301 70.0 3e-10 XP_016878187 (OMIM: 176270,227220,605837,615516) P (2556) 301 70.0 3e-10 XP_011528088 (OMIM: 609314,615481) PREDICTED: radi ( 285) 285 66.5 3.9e-10 XP_011520435 (OMIM: 176270,227220,605837,615516) P (3749) 301 70.1 4.2e-10 XP_011520433 (OMIM: 176270,227220,605837,615516) P (4673) 301 70.1 5.1e-10 XP_006720790 (OMIM: 176270,227220,605837,615516) P (4748) 301 70.1 5.2e-10 XP_016878185 (OMIM: 176270,227220,605837,615516) P (4796) 301 70.1 5.3e-10 XP_016878184 (OMIM: 176270,227220,605837,615516) P (4796) 301 70.1 5.3e-10 XP_005268333 (OMIM: 176270,227220,605837,615516) P (4796) 301 70.1 5.3e-10 XP_006720789 (OMIM: 176270,227220,605837,615516) P (4829) 301 70.1 5.3e-10 NP_004658 (OMIM: 176270,227220,605837,615516) E3 u (4834) 301 70.1 5.3e-10 NP_001129676 (OMIM: 609587) protein RCC2 [Homo sap ( 522) 249 59.6 8.2e-08 NP_061185 (OMIM: 609587) protein RCC2 [Homo sapien ( 522) 249 59.6 8.2e-08 XP_011530355 (OMIM: 609249) PREDICTED: probable E3 ( 998) 253 60.5 8.5e-08 XP_005263140 (OMIM: 609249) PREDICTED: probable E3 (1034) 253 60.5 8.7e-08 NP_001158608 (OMIM: 609249) probable E3 ubiquitin- ( 986) 251 60.1 1.1e-07 NP_060382 (OMIM: 609249) probable E3 ubiquitin-pro (1022) 251 60.1 1.1e-07 XP_006723896 (OMIM: 605267,613873) PREDICTED: junc ( 147) 224 54.6 7.9e-07 XP_016875866 (OMIM: 603524) PREDICTED: RCC1 and BT ( 285) 224 54.7 1.4e-06 NP_787109 (OMIM: 605267,613873) junctophilin-2 iso ( 129) 211 52.0 4e-06 XP_016878973 (OMIM: 605268,606438) PREDICTED: junc ( 148) 211 52.0 4.5e-06 NP_001258534 (OMIM: 605268,606438) junctophilin-3 ( 150) 209 51.7 6e-06 XP_016864296 (OMIM: 605200) PREDICTED: probable E3 ( 924) 220 54.1 6.7e-06 NP_001258531 (OMIM: 605200) probable E3 ubiquitin- ( 932) 220 54.1 6.7e-06 XP_016878972 (OMIM: 605268,606438) PREDICTED: junc ( 176) 209 51.7 6.9e-06 >>NP_065970 (OMIM: 205100,606352,606353,607225) alsin is (1657 aa) initn: 11064 init1: 11064 opt: 11064 Z-score: 11579.5 bits: 2155.6 E(85289): 0 Smith-Waterman score: 11064; 99.9% identity (100.0% similar) in 1657 aa overlap (1-1657:1-1657) 10 20 30 40 50 60 pF1KSD MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SEHGEKPMPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKK :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SEHGEKPVPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 VMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD RLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 RLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD LLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD LSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 LSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD SYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLP 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD IRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 IRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD GKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD AEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 AEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSG 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD SSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD EDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 EDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD GKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEG 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD NFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 NFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKIT 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KSD GTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDN 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KSD IAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 IAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPL 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KSD HPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 HPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTI 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KSD PLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 PLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDRE 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KSD EDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 EDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQ 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KSD QISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 QISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSE 1570 1580 1590 1600 1610 1620 1630 1640 1650 pF1KSD VHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN ::::::::::::::::::::::::::::::::::::: NP_065 VHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN 1630 1640 1650 >>XP_006712717 (OMIM: 205100,606352,606353,607225) PREDI (1657 aa) initn: 11064 init1: 11064 opt: 11064 Z-score: 11579.5 bits: 2155.6 E(85289): 0 Smith-Waterman score: 11064; 99.9% identity (100.0% similar) in 1657 aa overlap (1-1657:1-1657) 10 20 30 40 50 60 pF1KSD MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SEHGEKPMPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKK :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SEHGEKPVPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD RLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD LLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD LSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD SYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLP 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD IRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD GKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD AEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSG 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD SSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD EDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD GKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEG 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD NFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKIT 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KSD GTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDN 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KSD IAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPL 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KSD HPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTI 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KSD PLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDRE 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KSD EDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQ 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KSD QISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSE 1570 1580 1590 1600 1610 1620 1630 1640 1650 pF1KSD VHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN ::::::::::::::::::::::::::::::::::::: XP_006 VHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN 1630 1640 1650 >>XP_016860058 (OMIM: 205100,606352,606353,607225) PREDI (1656 aa) initn: 8529 init1: 8529 opt: 11038 Z-score: 11552.3 bits: 2150.5 E(85289): 0 Smith-Waterman score: 11038; 99.8% identity (99.9% similar) in 1657 aa overlap (1-1657:1-1656) 10 20 30 40 50 60 pF1KSD MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SEHGEKPMPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKK :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEHGEKPVPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD RLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD LLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD LSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD SYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLP 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD IRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD GKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD AEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSG 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD SSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD EDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD GKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEG 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD NFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKIT 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KSD GTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDN ::::::::::::::::::. :::::::::::::::::::::::::::::::::::::::: XP_016 GTYFKPSLYESDKDRPKVL-KLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDN 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 1380 pF1KSD IAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPL 1320 1330 1340 1350 1360 1370 1390 1400 1410 1420 1430 1440 pF1KSD HPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTI 1380 1390 1400 1410 1420 1430 1450 1460 1470 1480 1490 1500 pF1KSD PLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDRE 1440 1450 1460 1470 1480 1490 1510 1520 1530 1540 1550 1560 pF1KSD EDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQ 1500 1510 1520 1530 1540 1550 1570 1580 1590 1600 1610 1620 pF1KSD QISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSE 1560 1570 1580 1590 1600 1610 1630 1640 1650 pF1KSD VHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN ::::::::::::::::::::::::::::::::::::: XP_016 VHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN 1620 1630 1640 1650 >>XP_011509832 (OMIM: 205100,606352,606353,607225) PREDI (1544 aa) initn: 10306 init1: 10306 opt: 10306 Z-score: 10786.2 bits: 2008.7 E(85289): 0 Smith-Waterman score: 10306; 99.9% identity (100.0% similar) in 1544 aa overlap (114-1657:1-1544) 90 100 110 120 130 140 pF1KSD LENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSE :::::::::::::::::::::::::::::: XP_011 MWGENSAGQCAVANQQYVPEPNPVSIADSE 10 20 30 150 160 170 180 190 200 pF1KSD ASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVV 40 50 60 70 80 90 210 220 230 240 250 260 pF1KSD LQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPLGVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPLGVTL 100 110 120 130 140 150 270 280 290 300 310 320 pF1KSD TESQAENHASTALSPSTETLDRQEEVFENTLVANDQSVATELNAVSAQITSSDAMSSQQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TESQAENHASTALSPSTETLDRQEEVFENTLVANDQSVATELNAVSAQITSSDAMSSQQN 160 170 180 190 200 210 330 340 350 360 370 380 pF1KSD VMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVREDSEHGEKPMPSQPLLEEAIPNLHS ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: XP_011 VMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVREDSEHGEKPVPSQPLLEEAIPNLHS 220 230 240 250 260 270 390 400 410 420 430 440 pF1KSD PPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKKVMNFYSTTPCETGAQAGSSAIGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKKVMNFYSTTPCETGAQAGSSAIGP 280 290 300 310 320 330 450 460 470 480 490 500 pF1KSD EGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSRRLSLPGLLSQVSPRLLRKAARVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSRRLSLPGLLSQVSPRLLRKAARVK 340 350 360 370 380 390 510 520 530 540 550 560 pF1KSD TRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIH 400 410 420 430 440 450 570 580 590 600 610 620 pF1KSD LEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKISSENGVWSIAAGRDYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKISSENGVWSIAAGRDYSL 460 470 480 490 500 510 630 640 650 660 670 680 pF1KSD FLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSKLGYISRVTAGKDSYLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSKLGYISRVTAGKDSYLAL 520 530 540 550 560 570 690 700 710 720 730 740 pF1KSD VDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPLLSLENLGTTTTVQLLQEVASRFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPLLSLENLGTTTTVQLLQEVASRFS 580 590 600 610 620 630 750 760 770 780 790 800 pF1KSD KLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLDSYTEYCTSITNFLVMGGFQLLAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLDSYTEYCTSITNFLVMGGFQLLAK 640 650 660 670 680 690 810 820 830 840 850 860 pF1KSD PAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLPIRRLHNYAKVLLKLATCFEVASP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLPIRRLHNYAKVLLKLATCFEVASP 700 710 720 730 740 750 870 880 890 900 910 920 pF1KSD EYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFPGKMTDSLRKPERRLLCESSNRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFPGKMTDSLRKPERRLLCESSNRAL 760 770 780 790 800 810 930 940 950 960 970 980 pF1KSD SLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLWAEPLSEEAGGVNGLKITTPEEQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLWAEPLSEEAGGVNGLKITTPEEQF 820 830 840 850 860 870 990 1000 1010 1020 1030 1040 pF1KSD TLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSGSSVQRQEPPISRSAKYTFYKDPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSGSSVQRQEPPISRSAKYTFYKDPR 880 890 900 910 920 930 1050 1060 1070 1080 1090 1100 pF1KSD LKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGH 940 950 960 970 980 990 1110 1120 1130 1140 1150 1160 pF1KSD WKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGY 1000 1010 1020 1030 1040 1050 1170 1180 1190 1200 1210 1220 pF1KSD GVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEG 1060 1070 1080 1090 1100 1110 1230 1240 1250 1260 1270 1280 pF1KSD EFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKITGTYFKPSLYESDKDRPKVFRKLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKITGTYFKPSLYESDKDRPKVFRKLG 1120 1130 1140 1150 1160 1170 1290 1300 1310 1320 1330 1340 pF1KSD NLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDNIAVALTTSRRQHRDSPEILSRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDNIAVALTTSRRQHRDSPEILSRSQ 1180 1190 1200 1210 1220 1230 1350 1360 1370 1380 1390 1400 pF1KSD TQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPLHPLGRLVETLVAVYRMTYVGVGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPLHPLGRLVETLVAVYRMTYVGVGA 1240 1250 1260 1270 1280 1290 1410 1420 1430 1440 1450 1460 pF1KSD NRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTIPLSAPLPTERKSFCTGKSDSRSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTIPLSAPLPTERKSFCTGKSDSRSE 1300 1310 1320 1330 1340 1350 1470 1480 1490 1500 1510 1520 pF1KSD SPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDREEDIYWECVLRLNKQPDIALLGFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDREEDIYWECVLRLNKQPDIALLGFL 1360 1370 1380 1390 1400 1410 1530 1540 1550 1560 1570 1580 pF1KSD GVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQQISTTFTPSDKLKVIQQTFEEIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQQISTTFTPSDKLKVIQQTFEEIS 1420 1430 1440 1450 1460 1470 1590 1600 1610 1620 1630 1640 pF1KSD QSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSEVHLIEDLMDPYLQHGEQGIMFTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSEVHLIEDLMDPYLQHGEQGIMFTT 1480 1490 1500 1510 1520 1530 1650 pF1KSD LKACYYQIQREKLN :::::::::::::: XP_011 LKACYYQIQREKLN 1540 >>XP_016860059 (OMIM: 205100,606352,606353,607225) PREDI (1342 aa) initn: 8942 init1: 8942 opt: 8942 Z-score: 9358.7 bits: 1744.3 E(85289): 0 Smith-Waterman score: 8942; 99.9% identity (100.0% similar) in 1335 aa overlap (1-1335:1-1335) 10 20 30 40 50 60 pF1KSD MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SEHGEKPMPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKK :::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEHGEKPVPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD VMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD RLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD LLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD LSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD SYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLP 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD IRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFP 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD GKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLW 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD AEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSG 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD SSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGL 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KSD EDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRS 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KSD GKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEG 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KSD NFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKIT 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KSD GTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDN 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KSD IAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPL ::::::::::::::: XP_016 IAVALTTSRRQHRDSLQDLLWQ 1330 1340 >>XP_006712718 (OMIM: 205100,606352,606353,607225) PREDI (969 aa) initn: 6538 init1: 6538 opt: 6538 Z-score: 6843.3 bits: 1278.4 E(85289): 0 Smith-Waterman score: 6538; 100.0% identity (100.0% similar) in 969 aa overlap (689-1657:1-969) 660 670 680 690 700 710 pF1KSD PVLLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILR :::::::::::::::::::::::::::::: XP_006 MGYIASLHELATTERRFYSKLSDIKSQILR 10 20 30 720 730 740 750 760 770 pF1KSD PLLSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PLLSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLF 40 50 60 70 80 90 780 790 800 810 820 830 pF1KSD LDSYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDSYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFF 100 110 120 130 140 150 840 850 860 870 880 890 pF1KSD LPIRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LPIRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKT 160 170 180 190 200 210 900 910 920 930 940 950 pF1KSD FPGKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FPGKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLAT 220 230 240 250 260 270 960 970 980 990 1000 1010 pF1KSD LWAEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LWAEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYG 280 290 300 310 320 330 1020 1030 1040 1050 1060 1070 pF1KSD SGSSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SGSSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRN 340 350 360 370 380 390 1080 1090 1100 1110 1120 1130 pF1KSD GLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLL 400 410 420 430 440 450 1140 1150 1160 1170 1180 1190 pF1KSD RSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYY 460 470 480 490 500 510 1200 1210 1220 1230 1240 1250 pF1KSD EGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIK 520 530 540 550 560 570 1260 1270 1280 1290 1300 1310 pF1KSD ITGTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ITGTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAW 580 590 600 610 620 630 1320 1330 1340 1350 1360 1370 pF1KSD DNIAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DNIAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDT 640 650 660 670 680 690 1380 1390 1400 1410 1420 1430 pF1KSD PLHPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PLHPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGS 700 710 720 730 740 750 1440 1450 1460 1470 1480 1490 pF1KSD TIPLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TIPLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDND 760 770 780 790 800 810 1500 1510 1520 1530 1540 1550 pF1KSD REEDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 REEDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVEC 820 830 840 850 860 870 1560 1570 1580 1590 1600 1610 pF1KSD LQQISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LQQISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLG 880 890 900 910 920 930 1620 1630 1640 1650 pF1KSD SEVHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN ::::::::::::::::::::::::::::::::::::::: XP_006 SEVHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN 940 950 960 >>XP_016860060 (OMIM: 205100,606352,606353,607225) PREDI (968 aa) initn: 4003 init1: 4003 opt: 6512 Z-score: 6816.0 bits: 1273.4 E(85289): 0 Smith-Waterman score: 6512; 99.8% identity (99.9% similar) in 969 aa overlap (689-1657:1-968) 660 670 680 690 700 710 pF1KSD PVLLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILR :::::::::::::::::::::::::::::: XP_016 MGYIASLHELATTERRFYSKLSDIKSQILR 10 20 30 720 730 740 750 760 770 pF1KSD PLLSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLLSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLF 40 50 60 70 80 90 780 790 800 810 820 830 pF1KSD LDSYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDSYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFF 100 110 120 130 140 150 840 850 860 870 880 890 pF1KSD LPIRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPIRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKT 160 170 180 190 200 210 900 910 920 930 940 950 pF1KSD FPGKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPGKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLAT 220 230 240 250 260 270 960 970 980 990 1000 1010 pF1KSD LWAEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LWAEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYG 280 290 300 310 320 330 1020 1030 1040 1050 1060 1070 pF1KSD SGSSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGSSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRN 340 350 360 370 380 390 1080 1090 1100 1110 1120 1130 pF1KSD GLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLL 400 410 420 430 440 450 1140 1150 1160 1170 1180 1190 pF1KSD RSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYY 460 470 480 490 500 510 1200 1210 1220 1230 1240 1250 pF1KSD EGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIK 520 530 540 550 560 570 1260 1270 1280 1290 1300 1310 pF1KSD ITGTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAW ::::::::::::::::::::. :::::::::::::::::::::::::::::::::::::: XP_016 ITGTYFKPSLYESDKDRPKVL-KLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAW 580 590 600 610 620 1320 1330 1340 1350 1360 1370 pF1KSD DNIAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DNIAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDT 630 640 650 660 670 680 1380 1390 1400 1410 1420 1430 pF1KSD PLHPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLHPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGS 690 700 710 720 730 740 1440 1450 1460 1470 1480 1490 pF1KSD TIPLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TIPLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDND 750 760 770 780 790 800 1500 1510 1520 1530 1540 1550 pF1KSD REEDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REEDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVEC 810 820 830 840 850 860 1560 1570 1580 1590 1600 1610 pF1KSD LQQISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQQISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLG 870 880 890 900 910 920 1620 1630 1640 1650 pF1KSD SEVHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN ::::::::::::::::::::::::::::::::::::::: XP_016 SEVHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN 930 940 950 960 >>XP_016860061 (OMIM: 205100,606352,606353,607225) PREDI (863 aa) initn: 5881 init1: 5881 opt: 5881 Z-score: 6156.0 bits: 1151.1 E(85289): 0 Smith-Waterman score: 5881; 100.0% identity (100.0% similar) in 863 aa overlap (795-1657:1-863) 770 780 790 800 810 820 pF1KSD EARSLVILKHSSLFLDSYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVND :::::::::::::::::::::::::::::: XP_016 MGGFQLLAKPAIDFLNKNQELLQDLSEVND 10 20 30 830 840 850 860 870 880 pF1KSD ENTQLMEILNTLFFLPIRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENTQLMEILNTLFFLPIRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGR 40 50 60 70 80 90 890 900 910 920 930 940 pF1KSD KRKEAEYTLGFWKTFPGKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRKEAEYTLGFWKTFPGKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALV 100 110 120 130 140 150 950 960 970 980 990 1000 pF1KSD HAQFSTHHVFPLATLWAEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HAQFSTHHVFPLATLWAEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAV 160 170 180 190 200 210 1010 1020 1030 1040 1050 1060 pF1KSD DQALRGMSDLPPYGSGSSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DQALRGMSDLPPYGSGSSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVL 220 230 240 250 260 270 1070 1080 1090 1100 1110 1120 pF1KSD KWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFE 280 290 300 310 320 330 1130 1140 1150 1160 1170 1180 pF1KSD GCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVC 340 350 360 370 380 390 1190 1200 1210 1220 1230 1240 pF1KSD QGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDY 400 410 420 430 440 450 1250 1260 1270 1280 1290 1300 pF1KSD IEGYFSGEWGSGIKITGTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IEGYFSGEWGSGIKITGTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQL 460 470 480 490 500 510 1310 1320 1330 1340 1350 1360 pF1KSD GCEGPGQGEVWKAWDNIAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCEGPGQGEVWKAWDNIAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEK 520 530 540 550 560 570 1370 1380 1390 1400 1410 1420 pF1KSD YDDIRKYLIKACDTPLHPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YDDIRKYLIKACDTPLHPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQ 580 590 600 610 620 630 1430 1440 1450 1460 1470 1480 pF1KSD LVRFLFPELPEEGSTIPLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVRFLFPELPEEGSTIPLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPR 640 650 660 670 680 690 1490 1500 1510 1520 1530 1540 pF1KSD LYPPLFMLYALDNDREEDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYPPLFMLYALDNDREEDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVL 700 710 720 730 740 750 1550 1560 1570 1580 1590 1600 pF1KSD PTTKDACFASAVECLQQISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTTKDACFASAVECLQQISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPV 760 770 780 790 800 810 1610 1620 1630 1640 1650 pF1KSD FLYVVLRARIRNLGSEVHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLYVVLRARIRNLGSEVHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN 820 830 840 850 860 >>NP_001129217 (OMIM: 205100,606352,606353,607225) alsin (396 aa) initn: 2456 init1: 2456 opt: 2456 Z-score: 2574.4 bits: 487.3 E(85289): 1.2e-136 Smith-Waterman score: 2456; 99.7% identity (100.0% similar) in 371 aa overlap (1-371:1-371) 10 20 30 40 50 60 pF1KSD MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD SEHGEKPMPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKK :::::::.::: NP_001 SEHGEKPVPSQVPAQFYKIKVCLELNCMGFSLETLK 370 380 390 >>XP_016861609 (OMIM: 612402) PREDICTED: ALS2 C-terminal (752 aa) initn: 984 init1: 450 opt: 1213 Z-score: 1268.3 bits: 246.5 E(85289): 6.6e-64 Smith-Waterman score: 1313; 33.1% identity (63.1% similar) in 746 aa overlap (698-1430:9-732) 670 680 690 700 710 720 pF1KSD GYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPLLSLENLG : :. : . :. ..: .:.::: XP_016 MCNPEEAALLRLEEVFSATLAHVNSLVLQPLLPAAPDP 10 20 30 730 740 750 760 770 780 pF1KSD TTT----TVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEA--RSLVILKHSSLFLDS . ..:::.. . ..: . . ::. :. . .::..:. .. :.. XP_016 SDPWGRECLRLLQQLHKSSQQLWEVTEESLHSLQERLRYPDSTGLESLLLLRGADRVLQA 40 50 60 70 80 90 790 800 810 820 830 840 pF1KSD YTEYCTSITNFLVMGGFQLLAKPAIDFL-NKNQELLQDLSEVNDENTQLMEILNTLFFLP . :: : :. .:. .:: :: .. .. . : : :: :..:.. . :. . : XP_016 HIEYIESYTSCMVVQAFQKAAKRRSEYWRGQRKALRQLLSGVSSEGS-VGASLGQALHQP 100 110 120 130 140 150 850 860 870 880 890 pF1KSD I-RRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTF . .....:. .::.:. . : . . .. . . : . .. .: : ..:.:. XP_016 LAHHVQQYVLLLLSLGDTIGEHHPTRELVVNAVTLFGNLQSFMKQELDQAVATQALWHTL 160 170 180 190 200 210 900 910 920 930 940 950 pF1KSD PGKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATL :.. : : : .::: .:.. ... . .. .::.:::: : . :.: : . XP_016 RGRLRDVLCTPAHRLLQDSQDVPVTVAP---LRAERVLLFDDALVLLQGHNVHTFDLKLV 220 230 240 250 260 270 960 970 980 990 1000 1010 pF1KSD WAEPLSEEAGGVNG--LKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPY :..: : .: ... ::::.:.. .. : .. : .. :: :::.: .:.: XP_016 WVDP------GQDGCTFHLLTPEEEFSFCAKDSQGQAVWQWKVTWAVHQALHGKKDFPVL 280 290 300 310 320 1020 1030 1040 1050 1060 1070 pF1KSD GSGSSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFR :.: .. ..:: : :.::: . :: .:::.:.: :.:::.:.::::::. . : : XP_016 GAG--LEPSQPPDCRCAEYTFQAEGRLCQATYEGEWCRGRPHGKGTLKWPDGRNHVGNFC 330 340 350 360 370 380 1080 1090 1100 1110 1120 1130 pF1KSD NGLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGL .::: :.: .:. . .: : : ::.::.::: :. :.. ::..: ::...::: :. XP_016 QGLEHGFGIRLLPQASEDKFDCYKCHWREGSMCGYGICEYSTDEVYKGYFQEGLRHGFGV 390 400 410 420 430 440 1140 1150 1160 1170 1180 1190 pF1KSD LRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLY :.:: . .: . :.: ...:::. .: :::.:.:::: .: ::.::: :. XP_016 LESGP-QAPQPFRYTGHWERGQRSGYGIEEDGDRGERYIGMWQAGQRHGPGVMVTQAGVC 450 460 470 480 490 500 1200 1210 1220 1230 1240 1250 pF1KSD YEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGI :.:.:. .: .: :.::::::..::: :. : :: ::: .:.::: .:: :.. : :. XP_016 YQGTFQADKTVGPGILLSEDDSLYEGTFTRDLTLMGKGKVTFPNGFTLEGSFGSGAGRGL 510 520 530 540 550 560 1260 1270 1280 1290 1300 1310 pF1KSD KITGTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKA . :. .: . .. : :.:: : :.. .:..:.. .:.. : : . .. .: XP_016 HTQGVLDTAALPPDPSSTCK--RQLGVGAFPVESRWQGVYSP-FRDFVCAGCPR-DLQEA 570 580 590 600 610 620 1320 1330 1340 1350 1360 1370 pF1KSD WDNIAVALTTSRRQHRDSPEILSRSQTQ---TLESLEFIPQHVGAFSVEKYDDIRKYLIK .. : : :. : : . :: .:. .. :.: : ... : .. :: : XP_016 LLGFDV---QSSRELRRSQDYLSCERTHPEDSVGSMEDILEELLQHREPK--ALQLYLRK 630 640 650 660 670 1380 1390 1400 1410 1420 1430 pF1KSD ACDTPLHPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELP : .. :::::.:..::. ... ::.:::::..: . : .:.:.. .... : :. XP_016 ALSNSLHPLGKLLRTLMLTFQATYAGVGANKHLQELAQEEVKQHAQELWAAYRGLLRVAL 680 690 700 710 720 730 1440 1450 1460 1470 1480 1490 pF1KSD EEGSTIPLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYA XP_016 ERKGQALEEDEDTETR 740 750 1657 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 06:40:17 2016 done: Thu Nov 3 06:40:20 2016 Total Scan time: 18.630 Total Display time: 0.700 Function used was FASTA [36.3.4 Apr, 2011]