FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1589, 777 aa 1>>>pF1KSDA1589 777 - 777 aa - 777 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.6744+/-0.000453; mu= 15.1970+/- 0.028 mean_var=145.2248+/-32.074, 0's: 0 Z-trim(114.5): 164 B-trim: 921 in 1/52 Lambda= 0.106428 statistics sampled from 24232 (24440) to 24232 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.287), width: 16 Scan time: 12.290 The best scores are: opt bits E(85289) NP_067083 (OMIM: 605471) zinc finger FYVE domain-c ( 777) 5437 847.5 0 NP_001268663 (OMIM: 605471) zinc finger FYVE domai ( 763) 3467 545.0 4.4e-154 NP_848535 (OMIM: 605471) zinc finger FYVE domain-c ( 362) 2631 416.3 1.1e-115 NP_001268664 (OMIM: 605471) zinc finger FYVE domai ( 362) 2631 416.3 1.1e-115 XP_016876862 (OMIM: 605471) PREDICTED: zinc finger ( 362) 2631 416.3 1.1e-115 XP_016865384 (OMIM: 610327) PREDICTED: RUN and FYV ( 310) 252 51.0 9.2e-06 XP_006714985 (OMIM: 610327) PREDICTED: RUN and FYV ( 368) 252 51.1 1e-05 XP_016865383 (OMIM: 610327) PREDICTED: RUN and FYV ( 368) 252 51.1 1e-05 XP_016865382 (OMIM: 610327) PREDICTED: RUN and FYV ( 416) 252 51.1 1.1e-05 XP_016865381 (OMIM: 610327) PREDICTED: RUN and FYV ( 438) 252 51.1 1.2e-05 XP_005266050 (OMIM: 610327) PREDICTED: RUN and FYV ( 465) 252 51.2 1.2e-05 XP_016865380 (OMIM: 610327) PREDICTED: RUN and FYV ( 578) 252 51.3 1.4e-05 NP_001035542 (OMIM: 610327) RUN and FYVE domain-co ( 600) 252 51.3 1.5e-05 NP_001035541 (OMIM: 610327) RUN and FYVE domain-co ( 600) 252 51.3 1.5e-05 XP_006714984 (OMIM: 610327) PREDICTED: RUN and FYV ( 686) 252 51.3 1.6e-05 NP_079434 (OMIM: 610327) RUN and FYVE domain-conta ( 708) 252 51.3 1.6e-05 XP_005270014 (OMIM: 610328) PREDICTED: RUN and FYV ( 572) 239 49.3 5.6e-05 XP_005270013 (OMIM: 610328) PREDICTED: RUN and FYV ( 585) 239 49.3 5.7e-05 XP_005270012 (OMIM: 610328) PREDICTED: RUN and FYV ( 590) 239 49.3 5.8e-05 XP_011538244 (OMIM: 610328) PREDICTED: RUN and FYV ( 606) 239 49.3 5.9e-05 NP_001317032 (OMIM: 610328) RUN and FYVE domain-co ( 606) 239 49.3 5.9e-05 XP_005270010 (OMIM: 610328) PREDICTED: RUN and FYV ( 607) 239 49.3 5.9e-05 NP_060457 (OMIM: 610328) RUN and FYVE domain-conta ( 641) 239 49.3 6.1e-05 XP_016863994 (OMIM: 614176) PREDICTED: lateral sig ( 773) 234 48.6 0.00012 NP_001166130 (OMIM: 614176) lateral signaling targ ( 817) 234 48.6 0.00012 NP_001166127 (OMIM: 614176) lateral signaling targ ( 857) 234 48.7 0.00013 NP_066023 (OMIM: 614176) lateral signaling target ( 887) 234 48.7 0.00013 XP_016880786 (OMIM: 604375) PREDICTED: hepatocyte ( 768) 228 47.7 0.00022 XP_011523765 (OMIM: 604375) PREDICTED: hepatocyte ( 777) 228 47.7 0.00023 NP_004703 (OMIM: 604375) hepatocyte growth factor- ( 777) 228 47.7 0.00023 NP_004678 (OMIM: 603559) myotubularin-related prot (1195) 228 47.9 0.00031 XP_006722231 (OMIM: 603559) PREDICTED: myotubulari (1195) 228 47.9 0.00031 XP_005257843 (OMIM: 603559) PREDICTED: myotubulari (1195) 228 47.9 0.00031 XP_005257842 (OMIM: 603559) PREDICTED: myotubulari (1199) 228 47.9 0.00031 XP_011523762 (OMIM: 603559) PREDICTED: myotubulari (1199) 228 47.9 0.00031 XP_005257841 (OMIM: 603559) PREDICTED: myotubulari (1209) 228 47.9 0.00031 NP_694691 (OMIM: 603558) myotubularin-related prot (1161) 222 46.9 0.00057 XP_016884521 (OMIM: 603558) PREDICTED: myotubulari (1161) 222 46.9 0.00057 XP_005261865 (OMIM: 603558) PREDICTED: myotubulari (1174) 222 46.9 0.00057 NP_066576 (OMIM: 603558) myotubularin-related prot (1198) 222 47.0 0.00058 XP_016884520 (OMIM: 603558) PREDICTED: myotubulari (1207) 222 47.0 0.00059 XP_005261862 (OMIM: 603558) PREDICTED: myotubulari (1211) 222 47.0 0.00059 XP_016884518 (OMIM: 603558) PREDICTED: myotubulari (1244) 222 47.0 0.0006 NP_001171471 (OMIM: 121850,609414) 1-phosphatidyli ( 548) 211 44.9 0.0011 NP_076976 (OMIM: 613504) zinc finger FYVE domain-c ( 234) 201 43.0 0.0017 NP_001185882 (OMIM: 613504) zinc finger FYVE domai ( 252) 201 43.1 0.0018 XP_011537117 (OMIM: 605070) PREDICTED: early endos (1365) 212 45.5 0.0019 NP_003557 (OMIM: 605070) early endosome antigen 1 (1411) 212 45.5 0.0019 XP_016875507 (OMIM: 605070) PREDICTED: early endos (1417) 212 45.5 0.0019 XP_011537116 (OMIM: 605070) PREDICTED: early endos (1453) 212 45.5 0.0019 >>NP_067083 (OMIM: 605471) zinc finger FYVE domain-conta (777 aa) initn: 5437 init1: 5437 opt: 5437 Z-score: 4522.0 bits: 847.5 E(85289): 0 Smith-Waterman score: 5437; 100.0% identity (100.0% similar) in 777 aa overlap (1-777:1-777) 10 20 30 40 50 60 pF1KSD MSAQTSPAEKGLNPGLMCQESYACSGTDEAIFECDECCSLQCLRCEEELHRQERLRNHER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 MSAQTSPAEKGLNPGLMCQESYACSGTDEAIFECDECCSLQCLRCEEELHRQERLRNHER 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD IRLKPGHVPYCDLCKGLSGHLPGVRQRAIVRCQTCKINLCLECQKRTHSGGNKRRHPVTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 IRLKPGHVPYCDLCKGLSGHLPGVRQRAIVRCQTCKINLCLECQKRTHSGGNKRRHPVTV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD YNVSNLQESLEAEEMDEETKRKKMTEKVVSFLLVDENEEIQVTNEEDFIRKLDCKPDQHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 YNVSNLQESLEAEEMDEETKRKKMTEKVVSFLLVDENEEIQVTNEEDFIRKLDCKPDQHL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KVVSIFGNTGDGKSHTLNHTFFYGREVFKTSPTQESCTVGVWAAYDPVHKVAVIDTEGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 KVVSIFGNTGDGKSHTLNHTFFYGREVFKTSPTQESCTVGVWAAYDPVHKVAVIDTEGLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD GATVNLSQRTRLLLKVLAISDLVIYRTHADRLHNDLFKFLGDASEAYLKHFTKELKATTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 GATVNLSQRTRLLLKVLAISDLVIYRTHADRLHNDLFKFLGDASEAYLKHFTKELKATTA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD RCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSEVPEKLIQDRFRKLGRFPEAFSSIHYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 RCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSEVPEKLIQDRFRKLGRFPEAFSSIHYK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GTRTYNPPTDFSGLRRALEQLLENNTTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 GTRTYNPPTDFSGLRRALEQLLENNTTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD FFPDEYFTCSSLCLSCGVGCKKSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 FFPDEYFTCSSLCLSCGVGCKKSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD EVSVVPKTSASTDSPWMGLAKYAWSGYVIECPNCGVVYRSRQYWFGNQDPVDTVVRTEIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 EVSVVPKTSASTDSPWMGLAKYAWSGYVIECPNCGVVYRSRQYWFGNQDPVDTVVRTEIV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD HVWPGTDGFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 HVWPGTDGFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD ILSCNKCATSFKDNDTKHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 ILSCNKCATSFKDNDTKHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD QLAVTEAQVDDEGGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 QLAVTEAQVDDEGGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILH 670 680 690 700 710 720 730 740 750 760 770 pF1KSD CHNCRKEFSIKLSKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 CHNCRKEFSIKLSKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL 730 740 750 760 770 >>NP_001268663 (OMIM: 605471) zinc finger FYVE domain-co (763 aa) initn: 3755 init1: 3467 opt: 3467 Z-score: 2887.3 bits: 545.0 E(85289): 4.4e-154 Smith-Waterman score: 5294; 98.2% identity (98.2% similar) in 777 aa overlap (1-777:1-763) 10 20 30 40 50 60 pF1KSD MSAQTSPAEKGLNPGLMCQESYACSGTDEAIFECDECCSLQCLRCEEELHRQERLRNHER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSAQTSPAEKGLNPGLMCQESYACSGTDEAIFECDECCSLQCLRCEEELHRQERLRNHER 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD IRLKPGHVPYCDLCKGLSGHLPGVRQRAIVRCQTCKINLCLECQKRTHSGGNKRRHPVTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRLKPGHVPYCDLCKGLSGHLPGVRQRAIVRCQTCKINLCLECQKRTHSGGNKRRHPVTV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD YNVSNLQESLEAEEMDEETKRKKMTEKVVSFLLVDENEEIQVTNEEDFIRKLDCKPDQHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YNVSNLQESLEAEEMDEETKRKKMTEKVVSFLLVDENEEIQVTNEEDFIRKLDCKPDQHL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD KVVSIFGNTGDGKSHTLNHTFFYGREVFKTSPTQESCTVGVWAAYDPVHKVAVIDTEGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVVSIFGNTGDGKSHTLNHTFFYGREVFKTSPTQESCTVGVWAAYDPVHKVAVIDTEGLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD GATVNLSQRTRLLLKVLAISDLVIYRTHADRLHNDLFKFLGDASEAYLKHFTKELKATTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GATVNLSQRTRLLLKVLAISDLVIYRTHADRLHNDLFKFLGDASEAYLKHFTKELKATTA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD RCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSEVPEKLIQDRFRKLGRFPEAFSSIHYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSEVPEKLIQDRFRKLGRFPEAFSSIHYK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GTRTYNPPTDFSGLRRALEQLLENNTTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTRTYNPPTDFSGLRRALEQLLENNTTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD FFPDEYFTCSSLCLSCGVGCKKSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FFPDEYFTCSSLCLSCGVGCKKSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD EVSVVPKTSASTDSPWMGLAKYAWSGYVIECPNCGVVYRSRQYWFGNQDPVDTVVRTEIV :::::::::::::::::::::::::: :::::::::::::::::::: NP_001 EVSVVPKTSASTDSPWMGLAKYAWSG--------------RQYWFGNQDPVDTVVRTEIV 490 500 510 520 550 560 570 580 590 600 pF1KSD HVWPGTDGFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVWPGTDGFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQ 530 540 550 560 570 580 610 620 630 640 650 660 pF1KSD ILSCNKCATSFKDNDTKHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILSCNKCATSFKDNDTKHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNV 590 600 610 620 630 640 670 680 690 700 710 720 pF1KSD QLAVTEAQVDDEGGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLAVTEAQVDDEGGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILH 650 660 670 680 690 700 730 740 750 760 770 pF1KSD CHNCRKEFSIKLSKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CHNCRKEFSIKLSKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL 710 720 730 740 750 760 >>NP_848535 (OMIM: 605471) zinc finger FYVE domain-conta (362 aa) initn: 2631 init1: 2631 opt: 2631 Z-score: 2197.7 bits: 416.3 E(85289): 1.1e-115 Smith-Waterman score: 2631; 100.0% identity (100.0% similar) in 362 aa overlap (416-777:1-362) 390 400 410 420 430 440 pF1KSD TTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSCGVGCKKSMN :::::::::::::::::::::::::::::: NP_848 MAHSSFFPDEYFTCSSLCLSCGVGCKKSMN 10 20 30 450 460 470 480 490 500 pF1KSD HGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 HGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWS 40 50 60 70 80 90 510 520 530 540 550 560 pF1KSD GYVIECPNCGVVYRSRQYWFGNQDPVDTVVRTEIVHVWPGTDGFLKDNNNAAQRLLDGMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 GYVIECPNCGVVYRSRQYWFGNQDPVDTVVRTEIVHVWPGTDGFLKDNNNAAQRLLDGMN 100 110 120 130 140 150 570 580 590 600 610 620 pF1KSD FMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDTKHHCRACGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 FMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDTKHHCRACGE 160 170 180 190 200 210 630 640 650 660 670 680 pF1KSD GFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 GFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAV 220 230 240 250 260 270 690 700 710 720 730 740 pF1KSD QNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKLSKHHCRACGQGFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 QNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKLSKHHCRACGQGFC 280 290 300 310 320 330 750 760 770 pF1KSD DECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL :::::::::::::::::::::::::::::::: NP_848 DECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL 340 350 360 >>NP_001268664 (OMIM: 605471) zinc finger FYVE domain-co (362 aa) initn: 2631 init1: 2631 opt: 2631 Z-score: 2197.7 bits: 416.3 E(85289): 1.1e-115 Smith-Waterman score: 2631; 100.0% identity (100.0% similar) in 362 aa overlap (416-777:1-362) 390 400 410 420 430 440 pF1KSD TTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSCGVGCKKSMN :::::::::::::::::::::::::::::: NP_001 MAHSSFFPDEYFTCSSLCLSCGVGCKKSMN 10 20 30 450 460 470 480 490 500 pF1KSD HGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWS 40 50 60 70 80 90 510 520 530 540 550 560 pF1KSD GYVIECPNCGVVYRSRQYWFGNQDPVDTVVRTEIVHVWPGTDGFLKDNNNAAQRLLDGMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYVIECPNCGVVYRSRQYWFGNQDPVDTVVRTEIVHVWPGTDGFLKDNNNAAQRLLDGMN 100 110 120 130 140 150 570 580 590 600 610 620 pF1KSD FMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDTKHHCRACGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDTKHHCRACGE 160 170 180 190 200 210 630 640 650 660 670 680 pF1KSD GFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAV 220 230 240 250 260 270 690 700 710 720 730 740 pF1KSD QNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKLSKHHCRACGQGFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKLSKHHCRACGQGFC 280 290 300 310 320 330 750 760 770 pF1KSD DECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL :::::::::::::::::::::::::::::::: NP_001 DECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL 340 350 360 >>XP_016876862 (OMIM: 605471) PREDICTED: zinc finger FYV (362 aa) initn: 2631 init1: 2631 opt: 2631 Z-score: 2197.7 bits: 416.3 E(85289): 1.1e-115 Smith-Waterman score: 2631; 100.0% identity (100.0% similar) in 362 aa overlap (416-777:1-362) 390 400 410 420 430 440 pF1KSD TTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSCGVGCKKSMN :::::::::::::::::::::::::::::: XP_016 MAHSSFFPDEYFTCSSLCLSCGVGCKKSMN 10 20 30 450 460 470 480 490 500 pF1KSD HGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWS 40 50 60 70 80 90 510 520 530 540 550 560 pF1KSD GYVIECPNCGVVYRSRQYWFGNQDPVDTVVRTEIVHVWPGTDGFLKDNNNAAQRLLDGMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GYVIECPNCGVVYRSRQYWFGNQDPVDTVVRTEIVHVWPGTDGFLKDNNNAAQRLLDGMN 100 110 120 130 140 150 570 580 590 600 610 620 pF1KSD FMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDTKHHCRACGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDTKHHCRACGE 160 170 180 190 200 210 630 640 650 660 670 680 pF1KSD GFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAV 220 230 240 250 260 270 690 700 710 720 730 740 pF1KSD QNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKLSKHHCRACGQGFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKLSKHHCRACGQGFC 280 290 300 310 320 330 750 760 770 pF1KSD DECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL :::::::::::::::::::::::::::::::: XP_016 DECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL 340 350 360 >>XP_016865384 (OMIM: 610327) PREDICTED: RUN and FYVE do (310 aa) initn: 237 init1: 210 opt: 252 Z-score: 224.5 bits: 51.0 E(85289): 9.2e-06 Smith-Waterman score: 252; 47.8% identity (72.5% similar) in 69 aa overlap (703-771:232-298) 680 690 700 710 720 730 pF1KSD GGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKL :..: . :. : : ::..:.:::::. XP_016 QKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISR 210 220 230 240 250 260 740 750 760 770 pF1KSD SKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL ::::: ::. ::. :: .. :.:: . .::::: .:. XP_016 RKHHCRNCGHIFCNTCSSNELALPS--YPKPVRVCDSCHTLLLQRCSSTAS 270 280 290 300 310 >>XP_006714985 (OMIM: 610327) PREDICTED: RUN and FYVE do (368 aa) initn: 237 init1: 210 opt: 252 Z-score: 223.5 bits: 51.1 E(85289): 1e-05 Smith-Waterman score: 252; 47.8% identity (72.5% similar) in 69 aa overlap (703-771:290-356) 680 690 700 710 720 730 pF1KSD GGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKL :..: . :. : : ::..:.:::::. XP_006 QKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISR 260 270 280 290 300 310 740 750 760 770 pF1KSD SKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL ::::: ::. ::. :: .. :.:: . .::::: .:. XP_006 RKHHCRNCGHIFCNTCSSNELALPS--YPKPVRVCDSCHTLLLQRCSSTAS 320 330 340 350 360 >>XP_016865383 (OMIM: 610327) PREDICTED: RUN and FYVE do (368 aa) initn: 237 init1: 210 opt: 252 Z-score: 223.5 bits: 51.1 E(85289): 1e-05 Smith-Waterman score: 252; 47.8% identity (72.5% similar) in 69 aa overlap (703-771:290-356) 680 690 700 710 720 730 pF1KSD GGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKL :..: . :. : : ::..:.:::::. XP_016 QKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISR 260 270 280 290 300 310 740 750 760 770 pF1KSD SKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL ::::: ::. ::. :: .. :.:: . .::::: .:. XP_016 RKHHCRNCGHIFCNTCSSNELALPS--YPKPVRVCDSCHTLLLQRCSSTAS 320 330 340 350 360 >>XP_016865382 (OMIM: 610327) PREDICTED: RUN and FYVE do (416 aa) initn: 237 init1: 210 opt: 252 Z-score: 222.8 bits: 51.1 E(85289): 1.1e-05 Smith-Waterman score: 252; 47.8% identity (72.5% similar) in 69 aa overlap (703-771:338-404) 680 690 700 710 720 730 pF1KSD GGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKL :..: . :. : : ::..:.:::::. XP_016 QKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISR 310 320 330 340 350 360 740 750 760 770 pF1KSD SKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL ::::: ::. ::. :: .. :.:: . .::::: .:. XP_016 RKHHCRNCGHIFCNTCSSNELALPS--YPKPVRVCDSCHTLLLQRCSSTAS 370 380 390 400 410 >>XP_016865381 (OMIM: 610327) PREDICTED: RUN and FYVE do (438 aa) initn: 237 init1: 210 opt: 252 Z-score: 222.6 bits: 51.1 E(85289): 1.2e-05 Smith-Waterman score: 252; 47.8% identity (72.5% similar) in 69 aa overlap (703-771:360-426) 680 690 700 710 720 730 pF1KSD GGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILHCHNCRKEFSIKL :..: . :. : : ::..:.:::::. XP_016 QKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISR 330 340 350 360 370 380 740 750 760 770 pF1KSD SKHHCRACGQGFCDECSHDRRAVPSRGWDHPVRVCFNCNKKPGDL ::::: ::. ::. :: .. :.:: . .::::: .:. XP_016 RKHHCRNCGHIFCNTCSSNELALPS--YPKPVRVCDSCHTLLLQRCSSTAS 390 400 410 420 430 777 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 06:45:50 2016 done: Thu Nov 3 06:45:52 2016 Total Scan time: 12.290 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]