Result of FASTA (omim) for
pF1KSDA1736
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1736, 1238 aa
1>>>pF1KSDA1736 1238 - 1238 aa - 1238 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.3009+/-0.000356; mu= 5.8759+/- 0.022
mean_var=224.8494+/-48.638, 0's: 0 Z-trim(121.3): 57 B-trim: 3548 in 2/59
Lambda= 0.085532
statistics sampled from 37546 (37615) to 37546 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.737), E-opt: 0.2 (0.441), width: 16
Scan time: 18.300
The best scores are: opt bits E(85289)
NP_001287660 (OMIM: 611359) activating molecule in (1238) 8337 1042.4 0
XP_016873497 (OMIM: 611359) PREDICTED: activating (1024) 4854 612.6 4.3e-174
XP_005253066 (OMIM: 611359) PREDICTED: activating (1298) 4854 612.6 5.2e-174
XP_006718322 (OMIM: 611359) PREDICTED: activating (1298) 4854 612.6 5.2e-174
XP_005253068 (OMIM: 611359) PREDICTED: activating (1269) 4663 589.1 6.3e-167
XP_016873496 (OMIM: 611359) PREDICTED: activating (1209) 4661 588.8 7.2e-167
NP_001254712 (OMIM: 611359) activating molecule in (1179) 3507 446.4 5.2e-124
NP_060219 (OMIM: 611359) activating molecule in BE (1208) 3507 446.4 5.3e-124
XP_005253071 (OMIM: 611359) PREDICTED: activating (1208) 3507 446.4 5.3e-124
XP_006718323 (OMIM: 611359) PREDICTED: activating (1119) 3503 445.9 7e-124
NP_001254711 (OMIM: 611359) activating molecule in (1301) 3500 445.6 1e-123
>>NP_001287660 (OMIM: 611359) activating molecule in BEC (1238 aa)
initn: 8337 init1: 8337 opt: 8337 Z-score: 5568.2 bits: 1042.4 E(85289): 0
Smith-Waterman score: 8337; 100.0% identity (100.0% similar) in 1238 aa overlap (1-1238:1-1238)
10 20 30 40 50 60
pF1KSD MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD YTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPAR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD DMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEY
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD GASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGA
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD AHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL
1150 1160 1170 1180 1190 1200
1210 1220 1230
pF1KSD PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
::::::::::::::::::::::::::::::::::::::
NP_001 PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
1210 1220 1230
>>XP_016873497 (OMIM: 611359) PREDICTED: activating mole (1024 aa)
initn: 6260 init1: 4854 opt: 4854 Z-score: 3246.6 bits: 612.6 E(85289): 4.3e-174
Smith-Waterman score: 6149; 92.5% identity (93.3% similar) in 1013 aa overlap (1-953:1-1012)
10 20 30 40 50 60
pF1KSD MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD YTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPAR
670 680 690 700 710 720
pF1KSD ------------------------------------------------------------
XP_016 LSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFE
730 740 750 760 770 780
730 740 750 760 770 780
pF1KSD DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
790 800 810 820 830 840
790 800 810 820 830 840
pF1KSD GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
850 860 870 880 890 900
850 860 870 880 890 900
pF1KSD GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
910 920 930 940 950 960
910 920 930 940 950 960
pF1KSD ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
:::::::::::::::::::::::::::::::: :. . : . . ...:.::
XP_016 ASRRILLHPSTEHMVAQVFRLQQAHGGETSMR-VLVAPYVQRHQITQQMSLNSVIGGRED
970 980 990 1000 1010
970 980 990 1000 1010 1020
pF1KSD GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
XP_016 TSFFG
1020
>>XP_005253066 (OMIM: 611359) PREDICTED: activating mole (1298 aa)
initn: 8323 init1: 4854 opt: 4854 Z-score: 3245.1 bits: 612.6 E(85289): 5.2e-174
Smith-Waterman score: 8013; 95.3% identity (95.3% similar) in 1270 aa overlap (1-1210:1-1270)
10 20 30 40 50 60
pF1KSD MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD YTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPAR
670 680 690 700 710 720
pF1KSD ------------------------------------------------------------
XP_005 LSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFE
730 740 750 760 770 780
730 740 750 760 770 780
pF1KSD DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
790 800 810 820 830 840
790 800 810 820 830 840
pF1KSD GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
850 860 870 880 890 900
850 860 870 880 890 900
pF1KSD GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
910 920 930 940 950 960
910 920 930 940 950 960
pF1KSD ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
970 980 990 1000 1010 1020
970 980 990 1000 1010 1020
pF1KSD GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
1030 1040 1050 1060 1070 1080
1030 1040 1050 1060 1070 1080
pF1KSD DMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEY
1090 1100 1110 1120 1130 1140
1090 1100 1110 1120 1130 1140
pF1KSD GASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGA
1150 1160 1170 1180 1190 1200
1150 1160 1170 1180 1190 1200
pF1KSD AHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL
1210 1220 1230 1240 1250 1260
1210 1220 1230
pF1KSD PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
::::::::::
XP_005 PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
1270 1280 1290
>>XP_006718322 (OMIM: 611359) PREDICTED: activating mole (1298 aa)
initn: 8323 init1: 4854 opt: 4854 Z-score: 3245.1 bits: 612.6 E(85289): 5.2e-174
Smith-Waterman score: 8013; 95.3% identity (95.3% similar) in 1270 aa overlap (1-1210:1-1270)
10 20 30 40 50 60
pF1KSD MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD YTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPAR
670 680 690 700 710 720
pF1KSD ------------------------------------------------------------
XP_006 LSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFE
730 740 750 760 770 780
730 740 750 760 770 780
pF1KSD DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
790 800 810 820 830 840
790 800 810 820 830 840
pF1KSD GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
850 860 870 880 890 900
850 860 870 880 890 900
pF1KSD GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
910 920 930 940 950 960
910 920 930 940 950 960
pF1KSD ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
970 980 990 1000 1010 1020
970 980 990 1000 1010 1020
pF1KSD GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
1030 1040 1050 1060 1070 1080
1030 1040 1050 1060 1070 1080
pF1KSD DMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEY
1090 1100 1110 1120 1130 1140
1090 1100 1110 1120 1130 1140
pF1KSD GASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGA
1150 1160 1170 1180 1190 1200
1150 1160 1170 1180 1190 1200
pF1KSD AHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL
1210 1220 1230 1240 1250 1260
1210 1220 1230
pF1KSD PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
::::::::::
XP_006 PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
1270 1280 1290
>>XP_005253068 (OMIM: 611359) PREDICTED: activating mole (1269 aa)
initn: 8130 init1: 4661 opt: 4663 Z-score: 3117.8 bits: 589.1 E(85289): 6.3e-167
Smith-Waterman score: 8077; 95.8% identity (96.3% similar) in 1269 aa overlap (1-1238:1-1269)
10 20 30 40 50 60
pF1KSD MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
610 620 630 640 650 660
670 680 690 700 710
pF1KSD YTQSSRSGTVSQEALHQDMPEESSEEDSLRR----RLLESSLIS-LSRYDGAGSREHPIY
::::::::::::::::::::::::::::::: . .:. ::: :. .:
XP_005 YTQSSRSGTVSQEALHQDMPEESSEEDSLRRLSPAAYYAQRMIQYLSRRDSIRQRSMRYQ
670 680 690 700 710 720
720 730 740
pF1KSD PDPAR--------------------------DNGDRSRHRAPRNARMSAPSLGRFVPRRF
. : :::::::::::::::::::::::::::::
XP_005 QNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRF
730 740 750 760 770 780
750 760 770 780 790 800
pF1KSD LLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTK
790 800 810 820 830 840
810 820 830 840 850 860
pF1KSD FDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPH
850 860 870 880 890 900
870 880 890 900 910 920
pF1KSD NLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGET
910 920 930 940 950 960
930 940 950 960 970 980
pF1KSD SMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGVEYYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGVEYYW
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KSD DQLNETVFTVHSNSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPATSVTSQGTQTLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DQLNETVFTVHSNSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPATSVTSQGTQTLAL
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080 1090 1100
pF1KSD QLQNAETQTEREVPEPGTAASGPGEGEGSEYGASGEDALSRIQRLMAEGGMTAVVQREQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLQNAETQTEREVPEPGTAASGPGEGEGSEYGASGEDALSRIQRLMAEGGMTAVVQREQS
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KSD TTMASMGGFGNNIIVSHRIHRSSQTGTEPGAAHTSSPQPSTSRGLLPEAGQLAERGLSPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TTMASMGGFGNNIIVSHRIHRSSQTGTEPGAAHTSSPQPSTSRGLLPEAGQLAERGLSPR
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KSD TASWDQPGTPGREPTQPTLPSSSPVPIPVSLPSAEGPTLHCELTNNNHLLDGGSSRGDAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TASWDQPGTPGREPTQPTLPSSSPVPIPVSLPSAEGPTLHCELTNNNHLLDGGSSRGDAA
1210 1220 1230 1240 1250 1260
1230
pF1KSD GPRGEPRNR
:::::::::
XP_005 GPRGEPRNR
>>XP_016873496 (OMIM: 611359) PREDICTED: activating mole (1209 aa)
initn: 4661 init1: 4661 opt: 4661 Z-score: 3116.8 bits: 588.8 E(85289): 7.2e-167
Smith-Waterman score: 8076; 97.7% identity (97.7% similar) in 1238 aa overlap (1-1238:1-1209)
10 20 30 40 50 60
pF1KSD MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD YTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPAR
:::::::::::::::::::::::::::::::
XP_016 YTQSSRSGTVSQEALHQDMPEESSEEDSLRR-----------------------------
670 680 690
730 740 750 760 770 780
pF1KSD DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
700 710 720 730 740 750
790 800 810 820 830 840
pF1KSD GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
760 770 780 790 800 810
850 860 870 880 890 900
pF1KSD GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
820 830 840 850 860 870
910 920 930 940 950 960
pF1KSD ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KSD GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KSD DMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEY
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KSD GASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGA
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KSD AHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL
1120 1130 1140 1150 1160 1170
1210 1220 1230
pF1KSD PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
::::::::::::::::::::::::::::::::::::::
XP_016 PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
1180 1190 1200
>>NP_001254712 (OMIM: 611359) activating molecule in BEC (1179 aa)
initn: 5770 init1: 3483 opt: 3507 Z-score: 2347.4 bits: 446.4 E(85289): 5.2e-124
Smith-Waterman score: 7252; 88.7% identity (89.2% similar) in 1269 aa overlap (1-1238:1-1179)
10 20 30 40 50 60
pF1KSD MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
:::::::::::::::
NP_001 HNFLHMLSSRSSGIQ---------------------------------------------
250
310 320 330 340 350 360
pF1KSD CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
:::::::::::::::
NP_001 ---------------------------------------------TEPFHPPEQASSTQQ
260 270
370 380 390 400 410 420
pF1KSD DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
280 290 300 310 320 330
430 440 450 460 470 480
pF1KSD RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
340 350 360 370 380 390
490 500 510 520 530 540
pF1KSD SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
400 410 420 430 440 450
550 560 570 580 590 600
pF1KSD ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
460 470 480 490 500 510
610 620 630 640 650 660
pF1KSD QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
520 530 540 550 560 570
670 680 690 700 710
pF1KSD YTQSSRSGTVSQEALHQDMPEESSEEDSLRR----RLLESSLIS-LSRYDGAGSREHPIY
::::::::::::::::::::::::::::::: . .:. ::: :. .:
NP_001 YTQSSRSGTVSQEALHQDMPEESSEEDSLRRLSPAAYYAQRMIQYLSRRDSIRQRSMRYQ
580 590 600 610 620 630
720 730 740
pF1KSD PDPAR--------------------------DNGDRSRHRAPRNARMSAPSLGRFVPRRF
. : :::::::::::::::::::::::::::::
NP_001 QNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSAPSLGRFVPRRF
640 650 660 670 680 690
750 760 770 780 790 800
pF1KSD LLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIANTTYRLQWWDFTK
700 710 720 730 740 750
810 820 830 840 850 860
pF1KSD FDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRGFPDEGILAVYSLAPH
760 770 780 790 800 810
870 880 890 900 910 920
pF1KSD NLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTEHMVAQVFRLQQAHGGET
820 830 840 850 860 870
930 940 950 960 970 980
pF1KSD SMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGVEYYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNKGDLVICRPEALNSGVEYYW
880 890 900 910 920 930
990 1000 1010 1020 1030 1040
pF1KSD DQLNETVFTVHSNSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPATSVTSQGTQTLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQLNETVFTVHSNSRSSERPGTSRATWRTDRDMGLMNAIGLQPRNPATSVTSQGTQTLAL
940 950 960 970 980 990
1050 1060 1070 1080 1090 1100
pF1KSD QLQNAETQTEREVPEPGTAASGPGEGEGSEYGASGEDALSRIQRLMAEGGMTAVVQREQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLQNAETQTEREVPEPGTAASGPGEGEGSEYGASGEDALSRIQRLMAEGGMTAVVQREQS
1000 1010 1020 1030 1040 1050
1110 1120 1130 1140 1150 1160
pF1KSD TTMASMGGFGNNIIVSHRIHRSSQTGTEPGAAHTSSPQPSTSRGLLPEAGQLAERGLSPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTMASMGGFGNNIIVSHRIHRSSQTGTEPGAAHTSSPQPSTSRGLLPEAGQLAERGLSPR
1060 1070 1080 1090 1100 1110
1170 1180 1190 1200 1210 1220
pF1KSD TASWDQPGTPGREPTQPTLPSSSPVPIPVSLPSAEGPTLHCELTNNNHLLDGGSSRGDAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TASWDQPGTPGREPTQPTLPSSSPVPIPVSLPSAEGPTLHCELTNNNHLLDGGSSRGDAA
1120 1130 1140 1150 1160 1170
1230
pF1KSD GPRGEPRNR
:::::::::
NP_001 GPRGEPRNR
>>NP_060219 (OMIM: 611359) activating molecule in BECN1- (1208 aa)
initn: 5963 init1: 3483 opt: 3507 Z-score: 2347.2 bits: 446.4 E(85289): 5.3e-124
Smith-Waterman score: 7382; 88.4% identity (88.4% similar) in 1298 aa overlap (1-1238:1-1208)
10 20 30 40 50 60
pF1KSD MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
:::::::::::::::
NP_060 HNFLHMLSSRSSGIQ---------------------------------------------
250
310 320 330 340 350 360
pF1KSD CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
:::::::::::::::
NP_060 ---------------------------------------------TEPFHPPEQASSTQQ
260 270
370 380 390 400 410 420
pF1KSD DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
280 290 300 310 320 330
430 440 450 460 470 480
pF1KSD RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
340 350 360 370 380 390
490 500 510 520 530 540
pF1KSD SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
400 410 420 430 440 450
550 560 570 580 590 600
pF1KSD ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
460 470 480 490 500 510
610 620 630 640 650 660
pF1KSD QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
520 530 540 550 560 570
670 680 690 700 710 720
pF1KSD YTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 YTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPAR
580 590 600 610 620 630
pF1KSD ------------------------------------------------------------
NP_060 LSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFE
640 650 660 670 680 690
730 740 750 760 770 780
pF1KSD DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
700 710 720 730 740 750
790 800 810 820 830 840
pF1KSD GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
760 770 780 790 800 810
850 860 870 880 890 900
pF1KSD GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
820 830 840 850 860 870
910 920 930 940 950 960
pF1KSD ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KSD GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KSD DMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEY
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KSD GASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGA
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KSD AHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 AHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL
1120 1130 1140 1150 1160 1170
1210 1220 1230
pF1KSD PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
::::::::::::::::::::::::::::::::::::::
NP_060 PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
1180 1190 1200
>>XP_005253071 (OMIM: 611359) PREDICTED: activating mole (1208 aa)
initn: 5963 init1: 3483 opt: 3507 Z-score: 2347.2 bits: 446.4 E(85289): 5.3e-124
Smith-Waterman score: 7382; 88.4% identity (88.4% similar) in 1298 aa overlap (1-1238:1-1208)
10 20 30 40 50 60
pF1KSD MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
:::::::::::::::
XP_005 HNFLHMLSSRSSGIQ---------------------------------------------
250
310 320 330 340 350 360
pF1KSD CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
:::::::::::::::
XP_005 ---------------------------------------------TEPFHPPEQASSTQQ
260 270
370 380 390 400 410 420
pF1KSD DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
280 290 300 310 320 330
430 440 450 460 470 480
pF1KSD RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
340 350 360 370 380 390
490 500 510 520 530 540
pF1KSD SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
400 410 420 430 440 450
550 560 570 580 590 600
pF1KSD ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
460 470 480 490 500 510
610 620 630 640 650 660
pF1KSD QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
520 530 540 550 560 570
670 680 690 700 710 720
pF1KSD YTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPAR
580 590 600 610 620 630
pF1KSD ------------------------------------------------------------
XP_005 LSPAAYYAQRMIQYLSRRDSIRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFE
640 650 660 670 680 690
730 740 750 760 770 780
pF1KSD DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
700 710 720 730 740 750
790 800 810 820 830 840
pF1KSD GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
760 770 780 790 800 810
850 860 870 880 890 900
pF1KSD GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
820 830 840 850 860 870
910 920 930 940 950 960
pF1KSD ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KSD GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KSD DMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEY
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KSD GASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGA
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190 1200
pF1KSD AHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL
1120 1130 1140 1150 1160 1170
1210 1220 1230
pF1KSD PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
::::::::::::::::::::::::::::::::::::::
XP_005 PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
1180 1190 1200
>>XP_006718323 (OMIM: 611359) PREDICTED: activating mole (1119 aa)
initn: 5246 init1: 3490 opt: 3503 Z-score: 2345.0 bits: 445.9 E(85289): 7e-124
Smith-Waterman score: 7251; 90.4% identity (90.4% similar) in 1238 aa overlap (1-1238:1-1119)
10 20 30 40 50 60
pF1KSD MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEGKRVELPDSPRSTFLLA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEIHFWDWSRREPFAVVKTASEM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGTELSHYRQRALLQSQPVRRTPLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD HNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQPSTERPRTSAYIRLRQRVSYPTAE
:::::::::::::::
XP_006 HNFLHMLSSRSSGIQ---------------------------------------------
250
310 320 330 340 350 360
pF1KSD CCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASARATTPSFSFVQTEPFHPPEQASSTQQ
:::::::::::::::
XP_006 ---------------------------------------------TEPFHPPEQASSTQQ
260 270
370 380 390 400 410 420
pF1KSD DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGGPLSSHPSRYHREIAPGLTGSEWT
280 290 300 310 320 330
430 440 450 460 470 480
pF1KSD RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RTVLSLNSRSEAESMPPPRTSASSVSLLSVLRQQEGGSQASVYTSATEGRGFPASGLATE
340 350 360 370 380 390
490 500 510 520 530 540
pF1KSD SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SDGGNGSSQNNSGSIRHELQCDLRRFFLEYDRLQELDQSLSGEAPQTQQAQEMLNNNIES
400 410 420 430 440 450
550 560 570 580 590 600
pF1KSD ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ERPGPSHQPTPHSSENNSNLSRGHLNRCRACHNLLTFNNDTLRWERTTPNYSSGEASSSW
460 470 480 490 500 510
610 620 630 640 650 660
pF1KSD QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QVPSSFESVPSSGSQLPPLERTEGQTPSSSRLELSSSASPQEERTVGVAFNQETGHWERI
520 530 540 550 560 570
670 680 690 700 710 720
pF1KSD YTQSSRSGTVSQEALHQDMPEESSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPAR
:::::::::::::::::::::::::::::::
XP_006 YTQSSRSGTVSQEALHQDMPEESSEEDSLRR-----------------------------
580 590 600
730 740 750 760 770 780
pF1KSD DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DNGDRSRHRAPRNARMSAPSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLA
610 620 630 640 650 660
790 800 810 820 830 840
pF1KSD GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GAVIGDGQSAVASNIANTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISAD
670 680 690 700 710 720
850 860 870 880 890 900
pF1KSD GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GQLLAAFIPSSQRGFPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGL
730 740 750 760 770 780
910 920 930 940 950 960
pF1KSD ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASRRILLHPSTEHMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEP
790 800 810 820 830 840
970 980 990 1000 1010 1020
pF1KSD GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLGLAYGTNKGDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDR
850 860 870 880 890 900
1030 1040 1050 1060 1070 1080
pF1KSD DMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DMGLMNAIGLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEY
910 920 930 940 950 960
1090 1100 1110 1120 1130 1140
pF1KSD GASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GASGEDALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGA
970 980 990 1000 1010 1020
1150 1160 1170 1180 1190 1200
pF1KSD AHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AHTSSPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSL
1030 1040 1050 1060 1070 1080
1210 1220 1230
pF1KSD PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
::::::::::::::::::::::::::::::::::::::
XP_006 PSAEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR
1090 1100 1110
1238 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 07:10:43 2016 done: Thu Nov 3 07:10:45 2016
Total Scan time: 18.300 Total Display time: 0.550
Function used was FASTA [36.3.4 Apr, 2011]