FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1792, 764 aa 1>>>pF1KSDA1792 764 - 764 aa - 764 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4071+/-0.000431; mu= 19.4330+/- 0.027 mean_var=70.5673+/-14.314, 0's: 0 Z-trim(109.8): 36 B-trim: 0 in 0/52 Lambda= 0.152677 statistics sampled from 18015 (18039) to 18015 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.574), E-opt: 0.2 (0.212), width: 16 Scan time: 11.840 The best scores are: opt bits E(85289) NP_068598 (OMIM: 614272) FAST kinase domain-contai ( 764) 5063 1125.2 0 XP_011514064 (OMIM: 606965) PREDICTED: fas-activat ( 462) 180 49.6 3.6e-05 XP_011514063 (OMIM: 606965) PREDICTED: fas-activat ( 494) 180 49.6 3.8e-05 XP_005249989 (OMIM: 606965) PREDICTED: fas-activat ( 515) 180 49.6 4e-05 XP_005249990 (OMIM: 606965) PREDICTED: fas-activat ( 515) 180 49.6 4e-05 NP_006703 (OMIM: 606965) fas-activated serine/thre ( 549) 180 49.6 4.2e-05 XP_016867194 (OMIM: 606965) PREDICTED: fas-activat ( 353) 177 48.8 4.6e-05 NP_148936 (OMIM: 606965) fas-activated serine/thre ( 408) 177 48.9 5.2e-05 XP_011514065 (OMIM: 606965) PREDICTED: fas-activat ( 381) 162 45.5 0.00048 XP_016867193 (OMIM: 606965) PREDICTED: fas-activat ( 488) 162 45.6 0.00059 NP_001245390 (OMIM: 606965) fas-activated serine/t ( 522) 162 45.6 0.00063 XP_016867195 (OMIM: 606965) PREDICTED: fas-activat ( 310) 155 44.0 0.0012 NP_004740 (OMIM: 611325) protein TBRG4 isoform 1 [ ( 631) 146 42.2 0.0084 NP_001248763 (OMIM: 611325) protein TBRG4 isoform ( 642) 146 42.2 0.0085 >>NP_068598 (OMIM: 614272) FAST kinase domain-containing (764 aa) initn: 5063 init1: 5063 opt: 5063 Z-score: 6023.3 bits: 1125.2 E(85289): 0 Smith-Waterman score: 5063; 100.0% identity (100.0% similar) in 764 aa overlap (1-764:1-764) 10 20 30 40 50 60 pF1KSD MAATLKSLKLVRYRAFCSPSAFGAVRSVSYWNVSSTQHGGQDPPEHISLCHSAKKVKNIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 MAATLKSLKLVRYRAFCSPSAFGAVRSVSYWNVSSTQHGGQDPPEHISLCHSAKKVKNIC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD STFSSRRILTTSSAHPGLEFSKTSSSKASTLQLGSPRATGVDEEDVEVFDSFENMRVFLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 STFSSRRILTTSSAHPGLEFSKTSSSKASTLQLGSPRATGVDEEDVEVFDSFENMRVFLQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LRPEYRVHSYNASETSQLLSVSEGELILHKVRVNQNNLQAQVIVDYLCKLSSLPAEQHPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 LRPEYRVHSYNASETSQLLSVSEGELILHKVRVNQNNLQAQVIVDYLCKLSSLPAEQHPV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD LLGSTSFALLCQLSVKKIQLFDTQDLINVLKAFVILGIPHSHSMLDVYETKCCHQVWEMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 LLGSTSFALLCQLSVKKIQLFDTQDLINVLKAFVILGIPHSHSMLDVYETKCCHQVWEMN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD MDQLLLVADLWRYLGRKVPRFLNIFSSYLNLHWKDLSLSQLVHLIYVIGENRQVSQDLMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 MDQLLLVADLWRYLGRKVPRFLNIFSSYLNLHWKDLSLSQLVHLIYVIGENRQVSQDLMQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD KLESLILKYIDLINLEEVGTICLGFFKSSTNLSEFVMRKIGDLACANIQHLSSRSLVNIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 KLESLILKYIDLINLEEVGTICLGFFKSSTNLSEFVMRKIGDLACANIQHLSSRSLVNIV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD KMFRFTHVDHINFMKQIGEIAPQRIPSLGVQGVMHLTLYCSALRFLNEGVMNAVAASLPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 KMFRFTHVDHINFMKQIGEIAPQRIPSLGVQGVMHLTLYCSALRFLNEGVMNAVAASLPP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD RVAHCRSKDVAKILWSFGTLNYKPPNAEEFYSSLISEIHRKMPEFNQYPEHLPTCLLGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 RVAHCRSKDVAKILWSFGTLNYKPPNAEEFYSSLISEIHRKMPEFNQYPEHLPTCLLGLA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD FLEYFPVELIDFALSPGFVRLAQERTKFDLLKELYTLDGTVGIECPDYRGNRLSTHLQQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 FLEYFPVELIDFALSPGFVRLAQERTKFDLLKELYTLDGTVGIECPDYRGNRLSTHLQQE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD GSELLWYLAEKDMNSKPEFLETVFLLETMLGGPQYVKHHMILPHTRSSDLEVQLDVNLKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 GSELLWYLAEKDMNSKPEFLETVFLLETMLGGPQYVKHHMILPHTRSSDLEVQLDVNLKP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD LPFNREATPAENVAKLRLEHVGVSLTDDLMNKLLKGKARGHFQGKTESEPGQQPMELENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 LPFNREATPAENVAKLRLEHVGVSLTDDLMNKLLKGKARGHFQGKTESEPGQQPMELENK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD AAVPLGGFLCNVADKSGAMEMAGLCPAACMQTPRMKLAVQFTNRNQYCYGSRDLLGLHNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 AAVPLGGFLCNVADKSGAMEMAGLCPAACMQTPRMKLAVQFTNRNQYCYGSRDLLGLHNM 670 680 690 700 710 720 730 740 750 760 pF1KSD KRRQLARLGYRVVELSYWEWLPLLKRTRLEKLAFLHEKVFTSAL :::::::::::::::::::::::::::::::::::::::::::: NP_068 KRRQLARLGYRVVELSYWEWLPLLKRTRLEKLAFLHEKVFTSAL 730 740 750 760 >>XP_011514064 (OMIM: 606965) PREDICTED: fas-activated s (462 aa) initn: 144 init1: 64 opt: 180 Z-score: 213.8 bits: 49.6 E(85289): 3.6e-05 Smith-Waterman score: 180; 24.2% identity (53.2% similar) in 293 aa overlap (260-538:100-382) 230 240 250 260 270 280 pF1KSD TKCCHQVWEMNMDQLLLVADLWRYLGRKVPRFLNIFSSYLNLHWKDLSLSQLVHLIYVIG :.:. : . : ...: .: .:. XP_011 DRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQLLGSRP 70 80 90 100 110 120 290 300 310 320 330 pF1KSD ENRQVSQDLMQKLESLILKYIDLINLEEVGTICLGF-----FKSSTNL-----SEFVMRK . : : .: : .::.. .... . .:: . : :. : .: .: XP_011 RPPPVEQVTLQDLSQLIIRNCPSFDIHTIH-VCLHLAVLLGFPSDGPLVCALEQERRLR- 130 140 150 160 170 180 340 350 360 370 380 390 pF1KSD IGDLACANIQHL--SSRSLVNIVKMFRFTHVDHINFMKQIGEIAPQRI-PSLGVQGVMHL . .: : ....: .. :: . . .......: :... : . : ..:: XP_011 LPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLLAQHL 190 200 210 220 230 240 400 410 420 430 440 450 pF1KSD TLYCSALRFLNEGVMNAVAASLPPRVAHCRSKDVAKILWSFGTLNYKPPNAEEFYSSLIS . . :. . ...:.: : . .. :: : :.. :: ::: : . ..:. : XP_011 ARH----RLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLE-QQFMPCLER 250 260 270 280 290 300 460 470 480 490 500 510 pF1KSD EIHRKMPEFNQYPEHLPTCLLGLAFLEYFPVELIDFALSPGFVRLAQERTKFDLLKE-LY . : : . : . :..: :. .: . . :..::::. . . .... : XP_011 ILAR---EAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLS 310 320 330 340 350 520 530 540 550 560 570 pF1KSD TLDGTVGIECPDYRGNRLSTHLQQEGSELLWYLAEKDMNSKPEFLETVFLLETMLGGPQY :: .: .: : ::: :: . : XP_011 LLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYR 360 370 380 390 400 410 >>XP_011514063 (OMIM: 606965) PREDICTED: fas-activated s (494 aa) initn: 144 init1: 64 opt: 180 Z-score: 213.3 bits: 49.6 E(85289): 3.8e-05 Smith-Waterman score: 180; 24.2% identity (53.2% similar) in 293 aa overlap (260-538:100-382) 230 240 250 260 270 280 pF1KSD TKCCHQVWEMNMDQLLLVADLWRYLGRKVPRFLNIFSSYLNLHWKDLSLSQLVHLIYVIG :.:. : . : ...: .: .:. XP_011 DRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQLLGSRP 70 80 90 100 110 120 290 300 310 320 330 pF1KSD ENRQVSQDLMQKLESLILKYIDLINLEEVGTICLGF-----FKSSTNL-----SEFVMRK . : : .: : .::.. .... . .:: . : :. : .: .: XP_011 RPPPVEQVTLQDLSQLIIRNCPSFDIHTIH-VCLHLAVLLGFPSDGPLVCALEQERRLR- 130 140 150 160 170 180 340 350 360 370 380 390 pF1KSD IGDLACANIQHL--SSRSLVNIVKMFRFTHVDHINFMKQIGEIAPQRI-PSLGVQGVMHL . .: : ....: .. :: . . .......: :... : . : ..:: XP_011 LPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLLAQHL 190 200 210 220 230 240 400 410 420 430 440 450 pF1KSD TLYCSALRFLNEGVMNAVAASLPPRVAHCRSKDVAKILWSFGTLNYKPPNAEEFYSSLIS . . :. . ...:.: : . .. :: : :.. :: ::: : . ..:. : XP_011 ARH----RLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLE-QQFMPCLER 250 260 270 280 290 300 460 470 480 490 500 510 pF1KSD EIHRKMPEFNQYPEHLPTCLLGLAFLEYFPVELIDFALSPGFVRLAQERTKFDLLKE-LY . : : . : . :..: :. .: . . :..::::. . . .... : XP_011 ILAR---EAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLS 310 320 330 340 350 520 530 540 550 560 570 pF1KSD TLDGTVGIECPDYRGNRLSTHLQQEGSELLWYLAEKDMNSKPEFLETVFLLETMLGGPQY :: .: .: : ::: :: . : XP_011 LLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYR 360 370 380 390 400 410 >>XP_005249989 (OMIM: 606965) PREDICTED: fas-activated s (515 aa) initn: 144 init1: 64 opt: 180 Z-score: 213.1 bits: 49.6 E(85289): 4e-05 Smith-Waterman score: 180; 24.2% identity (53.2% similar) in 293 aa overlap (260-538:66-348) 230 240 250 260 270 280 pF1KSD TKCCHQVWEMNMDQLLLVADLWRYLGRKVPRFLNIFSSYLNLHWKDLSLSQLVHLIYVIG :.:. : . : ...: .: .:. XP_005 DRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQLLGSRP 40 50 60 70 80 90 290 300 310 320 330 pF1KSD ENRQVSQDLMQKLESLILKYIDLINLEEVGTICLGF-----FKSSTNL-----SEFVMRK . : : .: : .::.. .... . .:: . : :. : .: .: XP_005 RPPPVEQVTLQDLSQLIIRNCPSFDIHTIH-VCLHLAVLLGFPSDGPLVCALEQERRLR- 100 110 120 130 140 150 340 350 360 370 380 390 pF1KSD IGDLACANIQHL--SSRSLVNIVKMFRFTHVDHINFMKQIGEIAPQRI-PSLGVQGVMHL . .: : ....: .. :: . . .......: :... : . : ..:: XP_005 LPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLLAQHL 160 170 180 190 200 210 400 410 420 430 440 450 pF1KSD TLYCSALRFLNEGVMNAVAASLPPRVAHCRSKDVAKILWSFGTLNYKPPNAEEFYSSLIS . . :. . ...:.: : . .. :: : :.. :: ::: : . ..:. : XP_005 ARH----RLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLE-QQFMPCLER 220 230 240 250 260 460 470 480 490 500 510 pF1KSD EIHRKMPEFNQYPEHLPTCLLGLAFLEYFPVELIDFALSPGFVRLAQERTKFDLLKE-LY . : : . : . :..: :. .: . . :..::::. . . .... : XP_005 ILAR---EAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLS 270 280 290 300 310 320 520 530 540 550 560 570 pF1KSD TLDGTVGIECPDYRGNRLSTHLQQEGSELLWYLAEKDMNSKPEFLETVFLLETMLGGPQY :: .: .: : ::: :: . : XP_005 LLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYR 330 340 350 360 370 380 >>XP_005249990 (OMIM: 606965) PREDICTED: fas-activated s (515 aa) initn: 144 init1: 64 opt: 180 Z-score: 213.1 bits: 49.6 E(85289): 4e-05 Smith-Waterman score: 180; 24.2% identity (53.2% similar) in 293 aa overlap (260-538:66-348) 230 240 250 260 270 280 pF1KSD TKCCHQVWEMNMDQLLLVADLWRYLGRKVPRFLNIFSSYLNLHWKDLSLSQLVHLIYVIG :.:. : . : ...: .: .:. XP_005 DRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQLLGSRP 40 50 60 70 80 90 290 300 310 320 330 pF1KSD ENRQVSQDLMQKLESLILKYIDLINLEEVGTICLGF-----FKSSTNL-----SEFVMRK . : : .: : .::.. .... . .:: . : :. : .: .: XP_005 RPPPVEQVTLQDLSQLIIRNCPSFDIHTIH-VCLHLAVLLGFPSDGPLVCALEQERRLR- 100 110 120 130 140 150 340 350 360 370 380 390 pF1KSD IGDLACANIQHL--SSRSLVNIVKMFRFTHVDHINFMKQIGEIAPQRI-PSLGVQGVMHL . .: : ....: .. :: . . .......: :... : . : ..:: XP_005 LPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLLAQHL 160 170 180 190 200 210 400 410 420 430 440 450 pF1KSD TLYCSALRFLNEGVMNAVAASLPPRVAHCRSKDVAKILWSFGTLNYKPPNAEEFYSSLIS . . :. . ...:.: : . .. :: : :.. :: ::: : . ..:. : XP_005 ARH----RLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLE-QQFMPCLER 220 230 240 250 260 460 470 480 490 500 510 pF1KSD EIHRKMPEFNQYPEHLPTCLLGLAFLEYFPVELIDFALSPGFVRLAQERTKFDLLKE-LY . : : . : . :..: :. .: . . :..::::. . . .... : XP_005 ILAR---EAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLS 270 280 290 300 310 320 520 530 540 550 560 570 pF1KSD TLDGTVGIECPDYRGNRLSTHLQQEGSELLWYLAEKDMNSKPEFLETVFLLETMLGGPQY :: .: .: : ::: :: . : XP_005 LLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYR 330 340 350 360 370 380 >>NP_006703 (OMIM: 606965) fas-activated serine/threonin (549 aa) initn: 144 init1: 64 opt: 180 Z-score: 212.7 bits: 49.6 E(85289): 4.2e-05 Smith-Waterman score: 180; 24.2% identity (53.2% similar) in 293 aa overlap (260-538:100-382) 230 240 250 260 270 280 pF1KSD TKCCHQVWEMNMDQLLLVADLWRYLGRKVPRFLNIFSSYLNLHWKDLSLSQLVHLIYVIG :.:. : . : ...: .: .:. NP_006 DRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQLLGSRP 70 80 90 100 110 120 290 300 310 320 330 pF1KSD ENRQVSQDLMQKLESLILKYIDLINLEEVGTICLGF-----FKSSTNL-----SEFVMRK . : : .: : .::.. .... . .:: . : :. : .: .: NP_006 RPPPVEQVTLQDLSQLIIRNCPSFDIHTIH-VCLHLAVLLGFPSDGPLVCALEQERRLR- 130 140 150 160 170 180 340 350 360 370 380 390 pF1KSD IGDLACANIQHL--SSRSLVNIVKMFRFTHVDHINFMKQIGEIAPQRI-PSLGVQGVMHL . .: : ....: .. :: . . .......: :... : . : ..:: NP_006 LPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLLAQHL 190 200 210 220 230 240 400 410 420 430 440 450 pF1KSD TLYCSALRFLNEGVMNAVAASLPPRVAHCRSKDVAKILWSFGTLNYKPPNAEEFYSSLIS . . :. . ...:.: : . .. :: : :.. :: ::: : . ..:. : NP_006 ARH----RLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLE-QQFMPCLER 250 260 270 280 290 300 460 470 480 490 500 510 pF1KSD EIHRKMPEFNQYPEHLPTCLLGLAFLEYFPVELIDFALSPGFVRLAQERTKFDLLKE-LY . : : . : . :..: :. .: . . :..::::. . . .... : NP_006 ILAR---EAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLS 310 320 330 340 350 520 530 540 550 560 570 pF1KSD TLDGTVGIECPDYRGNRLSTHLQQEGSELLWYLAEKDMNSKPEFLETVFLLETMLGGPQY :: .: .: : ::: :: . : NP_006 LLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYR 360 370 380 390 400 410 >>XP_016867194 (OMIM: 606965) PREDICTED: fas-activated s (353 aa) initn: 150 init1: 64 opt: 177 Z-score: 211.9 bits: 48.8 E(85289): 4.6e-05 Smith-Waterman score: 177; 27.1% identity (57.1% similar) in 177 aa overlap (364-538:73-241) 340 350 360 370 380 390 pF1KSD EFVMRKIGDLACANIQHLSSRSLVNIVKMFRFTHVDHINFMKQIGEIAPQRI-PSLGVQG :: . . .......: :... : . : XP_016 RRLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLL 50 60 70 80 90 100 400 410 420 430 440 450 pF1KSD VMHLTLYCSALRFLNEGVMNAVAASLPPRVAHCRSKDVAKILWSFGTLNYKPPNAEEFYS ..::. . :. . ...:.: : . .. :: : :.. :: ::: : . ..:. XP_016 AQHLARH----RLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLE-QQFMP 110 120 130 140 150 460 470 480 490 500 510 pF1KSD SLISEIHRKMPEFNQYPEHLPTCLLGLAFLEYFPVELIDFALSPGFVRLAQERTKFDLLK : . : : . : . :..: :. .: . . :..::::. . . ... XP_016 CLERILAR---EAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVR 160 170 180 190 200 210 520 530 540 550 560 570 pF1KSD E-LYTLDGTVGIECPDYRGNRLSTHLQQEGSELLWYLAEKDMNSKPEFLETVFLLETMLG . : :: .: .: : ::: :: . : XP_016 RYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGE 220 230 240 250 260 270 >>NP_148936 (OMIM: 606965) fas-activated serine/threonin (408 aa) initn: 150 init1: 64 opt: 177 Z-score: 211.0 bits: 48.9 E(85289): 5.2e-05 Smith-Waterman score: 177; 27.1% identity (57.1% similar) in 177 aa overlap (364-538:73-241) 340 350 360 370 380 390 pF1KSD EFVMRKIGDLACANIQHLSSRSLVNIVKMFRFTHVDHINFMKQIGEIAPQRI-PSLGVQG :: . . .......: :... : . : NP_148 RRLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLL 50 60 70 80 90 100 400 410 420 430 440 450 pF1KSD VMHLTLYCSALRFLNEGVMNAVAASLPPRVAHCRSKDVAKILWSFGTLNYKPPNAEEFYS ..::. . :. . ...:.: : . .. :: : :.. :: ::: : . ..:. NP_148 AQHLARH----RLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLE-QQFMP 110 120 130 140 150 460 470 480 490 500 510 pF1KSD SLISEIHRKMPEFNQYPEHLPTCLLGLAFLEYFPVELIDFALSPGFVRLAQERTKFDLLK : . : : . : . :..: :. .: . . :..::::. . . ... NP_148 CLERILAR---EAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVR 160 170 180 190 200 210 520 530 540 550 560 570 pF1KSD E-LYTLDGTVGIECPDYRGNRLSTHLQQEGSELLWYLAEKDMNSKPEFLETVFLLETMLG . : :: .: .: : ::: :: . : NP_148 RYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGE 220 230 240 250 260 270 >>XP_011514065 (OMIM: 606965) PREDICTED: fas-activated s (381 aa) initn: 150 init1: 64 opt: 162 Z-score: 193.6 bits: 45.5 E(85289): 0.00048 Smith-Waterman score: 162; 28.4% identity (55.6% similar) in 162 aa overlap (379-538:61-214) 350 360 370 380 390 400 pF1KSD QHLSSRSLVNIVKMFRFTHVDHINFMKQIGEIAPQRI-PSLGVQGVMHLTLYCSALRFLN : :... : . : ..::. . :. . XP_011 SDGPLVCALEQERRLRLPPKPPPPLQPLLREARPEELTPHVMVLLAQHLARH----RLRE 40 50 60 70 80 410 420 430 440 450 460 pF1KSD EGVMNAVAASLPPRVAHCRSKDVAKILWSFGTLNYKPPNAEEFYSSLISEIHRKMPEFNQ ...:.: : . .. :: : :.. :: ::: : . ..:. : . : : . XP_011 PQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLE-QQFMPCLERILAR---EAGV 90 100 110 120 130 140 470 480 490 500 510 520 pF1KSD YPEHLPTCLLGLAFLEYFPVELIDFALSPGFVRLAQERTKFDLLKE-LYTLDGTVGIECP : . :..: :. .: . . :..::::. . . .... : :: .: .: : XP_011 APLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELP 150 160 170 180 190 200 530 540 550 560 570 580 pF1KSD DYRGNRLSTHLQQEGSELLWYLAEKDMNSKPEFLETVFLLETMLGGPQYVKHHMILPHTR ::: :: . : XP_011 GYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCT 210 220 230 240 250 260 >>XP_016867193 (OMIM: 606965) PREDICTED: fas-activated s (488 aa) initn: 185 init1: 64 opt: 162 Z-score: 192.0 bits: 45.6 E(85289): 0.00059 Smith-Waterman score: 169; 24.6% identity (51.2% similar) in 281 aa overlap (260-538:66-321) 230 240 250 260 270 280 pF1KSD TKCCHQVWEMNMDQLLLVADLWRYLGRKVPRFLNIFSSYLNLHWKDLSLSQLVHLIYVIG :.:. : . : ...: .: .:. XP_016 DRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQLLGSRP 40 50 60 70 80 90 290 300 310 320 330 340 pF1KSD ENRQVSQDLMQKLESLILKYIDLINLEEVGTICLGFFKSSTNLSEFVMRKIGDLACANIQ . : : .: : .::.. .... . .:: . . : : . : :.:: : XP_016 RPPPVEQVTLQDLSQLIIRNCPSFDIHTIH-VCLHL----AVLLGF--PSDGPLVCALEQ 100 110 120 130 140 350 360 370 380 390 400 pF1KSD HLSSRSLVNIVKMFRFTHVDHINFMKQIGEIAPQRI-PSLGVQGVMHLTLYCSALRFLNE . . .:. .. . : :... : . : ..::. . :. . XP_016 E----------RRLRLPPKPPPPLQPLLREARPEELTPHVMVLLAQHLARH----RLREP 150 160 170 180 190 410 420 430 440 450 460 pF1KSD GVMNAVAASLPPRVAHCRSKDVAKILWSFGTLNYKPPNAEEFYSSLISEIHRKMPEFNQY ...:.: : . .. :: : :.. :: ::: : . ..:. : . : : . XP_016 QLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLE-QQFMPCLERILAR---EAGVA 200 210 220 230 240 250 470 480 490 500 510 520 pF1KSD PEHLPTCLLGLAFLEYFPVELIDFALSPGFVRLAQERTKFDLLKE-LYTLDGTVGIECPD : . :..: :. .: . . :..::::. . . .... : :: .: .: : XP_016 PLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPG 260 270 280 290 300 310 530 540 550 560 570 580 pF1KSD YRGNRLSTHLQQEGSELLWYLAEKDMNSKPEFLETVFLLETMLGGPQYVKHHMILPHTRS ::: :: . : XP_016 YRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTD 320 330 340 350 360 370 764 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 07:21:42 2016 done: Thu Nov 3 07:21:44 2016 Total Scan time: 11.840 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]