FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1872, 371 aa 1>>>pF1KSDA1872 371 - 371 aa - 371 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8765+/-0.000321; mu= 13.8889+/- 0.020 mean_var=79.0580+/-15.916, 0's: 0 Z-trim(115.9): 50 B-trim: 1400 in 1/58 Lambda= 0.144245 statistics sampled from 26536 (26592) to 26536 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.685), E-opt: 0.2 (0.312), width: 16 Scan time: 8.720 The best scores are: opt bits E(85289) NP_149053 (OMIM: 601238,608179) caytaxin [Homo sap ( 371) 2476 524.7 1.3e-148 XP_006717047 (OMIM: 610691) PREDICTED: protein pru (3101) 1252 270.5 3.7e-71 XP_006717045 (OMIM: 610691) PREDICTED: protein pru (3104) 1250 270.1 5e-71 XP_011516628 (OMIM: 610691) PREDICTED: protein pru (3085) 1247 269.4 7.7e-71 XP_005251808 (OMIM: 610691) PREDICTED: protein pru (3075) 1246 269.2 8.8e-71 XP_011516630 (OMIM: 610691) PREDICTED: protein pru (3072) 1245 269.0 1e-70 XP_005251803 (OMIM: 610691) PREDICTED: protein pru (3091) 1245 269.0 1e-70 XP_005251802 (OMIM: 610691) PREDICTED: protein pru (3092) 1235 266.9 4.3e-70 NP_001294977 (OMIM: 610691) protein prune homolog (3063) 1215 262.8 7.7e-69 XP_016869842 (OMIM: 610691) PREDICTED: protein pru (3068) 1215 262.8 7.7e-69 XP_011516629 (OMIM: 610691) PREDICTED: protein pru (3079) 1215 262.8 7.7e-69 XP_016869843 (OMIM: 610691) PREDICTED: protein pru ( 365) 1019 221.5 2.4e-57 XP_016869848 (OMIM: 610691) PREDICTED: protein pru ( 336) 1015 220.7 4e-57 XP_006717049 (OMIM: 610691) PREDICTED: protein pru (3100) 1027 223.6 4.6e-57 XP_016869845 (OMIM: 610691) PREDICTED: protein pru ( 352) 1014 220.5 4.8e-57 XP_016869847 (OMIM: 610691) PREDICTED: protein pru ( 337) 1012 220.0 6.2e-57 NP_001294978 (OMIM: 610691) protein prune homolog ( 337) 1012 220.0 6.2e-57 NP_001294979 (OMIM: 610691) protein prune homolog ( 352) 1012 220.0 6.4e-57 XP_016869841 (OMIM: 610691) PREDICTED: protein pru (3071) 1023 222.8 8.2e-57 XP_016869835 (OMIM: 610691) PREDICTED: protein pru (3087) 1022 222.6 9.5e-57 NP_001307603 (OMIM: 603292) BCL2/adenovirus E1B 19 ( 447) 1008 219.3 1.4e-56 XP_006717048 (OMIM: 610691) PREDICTED: protein pru (3101) 1019 222.0 1.5e-56 NP_001317609 (OMIM: 610691) protein prune homolog ( 353) 1004 218.4 2e-56 XP_016869840 (OMIM: 610691) PREDICTED: protein pru (3072) 1015 221.1 2.6e-56 XP_005251807 (OMIM: 610691) PREDICTED: protein pru (3088) 1014 220.9 3e-56 NP_056040 (OMIM: 610691) protein prune homolog 2 i (3088) 1012 220.5 4e-56 XP_006717046 (OMIM: 610691) PREDICTED: protein pru (3103) 1011 220.3 4.7e-56 XP_016869839 (OMIM: 610691) PREDICTED: protein pru (3074) 1007 219.5 8.3e-56 XP_005251805 (OMIM: 610691) PREDICTED: protein pru (3090) 1006 219.3 9.6e-56 XP_011516625 (OMIM: 610691) PREDICTED: protein pru (3089) 1004 218.9 1.3e-55 NP_001294980 (OMIM: 610691) protein prune homolog ( 324) 984 214.2 3.4e-55 XP_016869846 (OMIM: 610691) PREDICTED: protein pru ( 340) 984 214.2 3.5e-55 XP_016869834 (OMIM: 610691) PREDICTED: protein pru (3091) 996 217.2 4.1e-55 XP_016869838 (OMIM: 610691) PREDICTED: protein pru (3075) 992 216.4 7.2e-55 NP_001307604 (OMIM: 603292) BCL2/adenovirus E1B 19 ( 376) 974 212.2 1.6e-54 NP_004321 (OMIM: 603292) BCL2/adenovirus E1B 19 kD ( 435) 974 212.2 1.8e-54 XP_005251811 (OMIM: 610691) PREDICTED: protein pru (3060) 984 214.7 2.3e-54 XP_016869837 (OMIM: 610691) PREDICTED: protein pru (3076) 984 214.7 2.3e-54 NP_612122 (OMIM: 611275) bcl-2/adenovirus E1B 19 k ( 357) 969 211.1 3.2e-54 NP_001294976 (OMIM: 610691) protein prune homolog (3062) 976 213.0 7.2e-54 XP_016869836 (OMIM: 610691) PREDICTED: protein pru (3078) 976 213.0 7.2e-54 NP_001153114 (OMIM: 611275) bcl-2/adenovirus E1B 1 ( 275) 845 185.2 1.5e-46 XP_011507538 (OMIM: 611275) PREDICTED: bcl-2/adeno ( 343) 811 178.2 2.4e-44 XP_016855909 (OMIM: 611275) PREDICTED: bcl-2/adeno ( 191) 696 154.2 2.4e-37 NP_001185655 (OMIM: 609405) rho GTPase-activating ( 305) 348 81.8 2.2e-15 XP_011518397 (OMIM: 602732) PREDICTED: rho GTPase- ( 439) 349 82.1 2.6e-15 NP_004299 (OMIM: 602732) rho GTPase-activating pro ( 439) 349 82.1 2.6e-15 NP_851852 (OMIM: 609405) rho GTPase-activating pro ( 433) 348 81.9 3e-15 XP_016873209 (OMIM: 602732) PREDICTED: rho GTPase- ( 395) 211 53.4 1.1e-06 NP_001017526 (OMIM: 609405) rho GTPase-activating ( 464) 201 51.3 5.2e-06 >>NP_149053 (OMIM: 601238,608179) caytaxin [Homo sapiens (371 aa) initn: 2476 init1: 2476 opt: 2476 Z-score: 2789.1 bits: 524.7 E(85289): 1.3e-148 Smith-Waterman score: 2476; 100.0% identity (100.0% similar) in 371 aa overlap (1-371:1-371) 10 20 30 40 50 60 pF1KSD MGTTEATLRMENVDVKEEWQDEDLPRPLPEETGVELLGSPVEDTSSPPNTLNFNGAHRKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 MGTTEATLRMENVDVKEEWQDEDLPRPLPEETGVELLGSPVEDTSSPPNTLNFNGAHRKR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD KTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLGNGNELEWED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 KTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLGNGNELEWED 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD DTPVATAKNMPGDSADLFGDGTTEDGSAANGRLWRTVIIGEQEHRIDLHMIRPYMKVVTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 DTPVATAKNMPGDSADLFGDGTTEDGSAANGRLWRTVIIGEQEHRIDLHMIRPYMKVVTH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD GGYYGEGLNAIIVFAACFLPDSSLPDYHYIMENLFLYVISSLELLVAEDYMIVYLNGATP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 GGYYGEGLNAIIVFAACFLPDSSLPDYHYIMENLFLYVISSLELLVAEDYMIVYLNGATP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD RRRMPGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFISVKFINKIQYVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 RRRMPGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFISVKFINKIQYVH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD SLEDLEQLIPMEHVQIPDCVLQYEEERLKARRESARPQPEFVLPRSEEKPEVAPVENRSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_149 SLEDLEQLIPMEHVQIPDCVLQYEEERLKARRESARPQPEFVLPRSEEKPEVAPVENRSA 310 320 330 340 350 360 370 pF1KSD LVSEDQETSMS ::::::::::: NP_149 LVSEDQETSMS 370 >>XP_006717047 (OMIM: 610691) PREDICTED: protein prune h (3101 aa) initn: 1105 init1: 818 opt: 1252 Z-score: 1398.4 bits: 270.5 E(85289): 3.7e-71 Smith-Waterman score: 1276; 57.6% identity (79.7% similar) in 349 aa overlap (22-367:2763-3095) 10 20 30 40 50 pF1KSD MGTTEATLRMENVDVKEEWQDEDLPRPLPEETGVELLGSPVEDTSSPPNTL ::. .: : :: : : .. :::.: XP_006 KNMIPDTEMEEETEFLELGTRISRPNGLLSEDVGMDIPFEEGV-LSPSAADMRPEPPNSL 2740 2750 2760 2770 2780 2790 60 70 80 90 100 110 pF1KSD NFNGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLG ..: .: .: :.::.::.::::::::.:::: ::.::..:::::...::::.::.:. : XP_006 DLNDTHPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDEIDINVDELDTPDEADSFEYTG 2800 2810 2820 2830 2840 2850 120 130 140 150 160 170 pF1KSD NGNELEWEDDTPVATAKNMPGDSADLFGDGTTEDGSAANGRLWRTVIIGEQEHRIDLHMI . :: : ::.. :. .. . . :.:. : ::::::.:::::.:::...: XP_006 H------ED--P--TANKDSGQESESIPEYTAEEEREDN-RLWRTVVIGEQEQRIDMKVI 2860 2870 2880 2890 2900 180 190 200 210 220 pF1KSD RPYMKVVTHGG---YYGEGLNAIIVFAACFLPDSSLPDYHYIMENLFLYVISSLELLVAE .:: .:..::: :::.::::::::::::::::: ::::.::::::::::.:::.::: XP_006 EPYRRVISHGGDSGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLYVISTLELMVAE 2910 2920 2930 2940 2950 2960 230 240 250 260 270 280 pF1KSD DYMIVYLNGATPRRRMPGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFI ::::::::::::::::::.::.:::::::::::::::::.:::::::::::.::..:::: XP_006 DYMIVYLNGATPRRRMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFI 2970 2980 2990 3000 3010 3020 290 300 310 320 330 340 pF1KSD SVKFINKIQYVHSLEDLEQLIPMEHVQIPDCVLQYEEERLKARRESARPQPEFVLPRSEE : :: .::.::.:: .: ::::. ..::. ...:.::: . ..:.: . : : .. : XP_006 SSKFSSKIKYVNSLSELSGLIPMDCIHIPESIIKYDEER--SYKRSVRLDEE--LREASE 3030 3040 3050 3060 3070 350 360 370 pF1KSD KPEVAPVENRSALVSEDQETSMS ... . : . : ..: XP_006 AAKTSCLYNDPEMSSMEKEKLCCVH 3080 3090 3100 >>XP_006717045 (OMIM: 610691) PREDICTED: protein prune h (3104 aa) initn: 1105 init1: 818 opt: 1250 Z-score: 1396.2 bits: 270.1 E(85289): 5e-71 Smith-Waterman score: 1274; 57.4% identity (79.0% similar) in 352 aa overlap (22-370:2763-3092) 10 20 30 40 50 pF1KSD MGTTEATLRMENVDVKEEWQDEDLPRPLPEETGVELLGSPVEDTSSPPNTL ::. .: : :: : : .. :::.: XP_006 KNMIPDTEMEEETEFLELGTRISRPNGLLSEDVGMDIPFEEGV-LSPSAADMRPEPPNSL 2740 2750 2760 2770 2780 2790 60 70 80 90 100 110 pF1KSD NFNGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLG ..: .: .: :.::.::.::::::::.:::: ::.::..:::::...::::.::.:. : XP_006 DLNDTHPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDEIDINVDELDTPDEADSFEYTG 2800 2810 2820 2830 2840 2850 120 130 140 150 160 170 pF1KSD NGNELEWEDDTPVATAKNMPGDSADLFGDGTTEDGSAANGRLWRTVIIGEQEHRIDLHMI . :: : ::.. :. .. . . :.:. : ::::::.:::::.:::...: XP_006 H------ED--P--TANKDSGQESESIPEYTAEEEREDN-RLWRTVVIGEQEQRIDMKVI 2860 2870 2880 2890 2900 180 190 200 210 220 pF1KSD RPYMKVVTHGG---YYGEGLNAIIVFAACFLPDSSLPDYHYIMENLFLYVISSLELLVAE .:: .:..::: :::.::::::::::::::::: ::::.::::::::::.:::.::: XP_006 EPYRRVISHGGDSGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLYVISTLELMVAE 2910 2920 2930 2940 2950 2960 230 240 250 260 270 280 pF1KSD DYMIVYLNGATPRRRMPGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFI ::::::::::::::::::.::.:::::::::::::::::.:::::::::::.::..:::: XP_006 DYMIVYLNGATPRRRMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFI 2970 2980 2990 3000 3010 3020 290 300 310 320 330 340 pF1KSD SVKFINKIQYVHSLEDLEQLIPMEHVQIPDCVLQYEEERLKARRESARPQPEFVLPRSEE : :: .::.::.:: .: ::::. ..::. ...:.::: . ..:.: .:: XP_006 SSKFSSKIKYVNSLSELSGLIPMDCIHIPESIIKYDEER--SYKRSVR--------LDEE 3030 3040 3050 3060 3070 350 360 370 pF1KSD KPEVAPVENRSALVSEDQETSMS :.. . . : : .. . .:: XP_006 LREASEAAKTSCLYNDPEMSSMEKDIDLKLKEKP 3080 3090 3100 >>XP_011516628 (OMIM: 610691) PREDICTED: protein prune h (3085 aa) initn: 1105 init1: 818 opt: 1247 Z-score: 1392.8 bits: 269.4 E(85289): 7.7e-71 Smith-Waterman score: 1271; 60.7% identity (82.0% similar) in 323 aa overlap (22-341:2763-3071) 10 20 30 40 50 pF1KSD MGTTEATLRMENVDVKEEWQDEDLPRPLPEETGVELLGSPVEDTSSPPNTL ::. .: : :: : : .. :::.: XP_011 KNMIPDTEMEEETEFLELGTRISRPNGLLSEDVGMDIPFEEGV-LSPSAADMRPEPPNSL 2740 2750 2760 2770 2780 2790 60 70 80 90 100 110 pF1KSD NFNGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLG ..: .: .: :.::.::.::::::::.:::: ::.::..:::::...::::.::.:. : XP_011 DLNDTHPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDEIDINVDELDTPDEADSFEYTG 2800 2810 2820 2830 2840 2850 120 130 140 150 160 170 pF1KSD NGNELEWEDDTPVATAKNMPGDSADLFGDGTTEDGSAANGRLWRTVIIGEQEHRIDLHMI . :: : ::.. :. .. . . :.:. : ::::::.:::::.:::...: XP_011 H------ED--P--TANKDSGQESESIPEYTAEEEREDN-RLWRTVVIGEQEQRIDMKVI 2860 2870 2880 2890 2900 180 190 200 210 220 pF1KSD RPYMKVVTHGG---YYGEGLNAIIVFAACFLPDSSLPDYHYIMENLFLYVISSLELLVAE .:: .:..::: :::.::::::::::::::::: ::::.::::::::::.:::.::: XP_011 EPYRRVISHGGDSGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLYVISTLELMVAE 2910 2920 2930 2940 2950 2960 230 240 250 260 270 280 pF1KSD DYMIVYLNGATPRRRMPGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFI ::::::::::::::::::.::.:::::::::::::::::.:::::::::::.::..:::: XP_011 DYMIVYLNGATPRRRMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFI 2970 2980 2990 3000 3010 3020 290 300 310 320 330 340 pF1KSD SVKFINKIQYVHSLEDLEQLIPMEHVQIPDCVLQYEEERLKARRESARPQPEFVLPRSEE : :: .::.::.:: .: ::::. ..::. ...:.::: . ..:.: . :. XP_011 SSKFSSKIKYVNSLSELSGLIPMDCIHIPESIIKYDEER--SYKRSVRLDEELREASEAA 3030 3040 3050 3060 3070 350 360 370 pF1KSD KPEVAPVENRSALVSEDQETSMS XP_011 KKLCCVH 3080 >>XP_005251808 (OMIM: 610691) PREDICTED: protein prune h (3075 aa) initn: 1142 init1: 818 opt: 1246 Z-score: 1391.7 bits: 269.2 E(85289): 8.8e-71 Smith-Waterman score: 1270; 61.7% identity (81.6% similar) in 316 aa overlap (22-334:2763-3066) 10 20 30 40 50 pF1KSD MGTTEATLRMENVDVKEEWQDEDLPRPLPEETGVELLGSPVEDTSSPPNTL ::. .: : :: : : .. :::.: XP_005 KNMIPDTEMEEETEFLELGTRISRPNGLLSEDVGMDIPFEEGV-LSPSAADMRPEPPNSL 2740 2750 2760 2770 2780 2790 60 70 80 90 100 110 pF1KSD NFNGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLG ..: .: .: :.::.::.::::::::.:::: ::.::..:::::...::::.::.:. : XP_005 DLNDTHPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDEIDINVDELDTPDEADSFEYTG 2800 2810 2820 2830 2840 2850 120 130 140 150 160 170 pF1KSD NGNELEWEDDTPVATAKNMPGDSADLFGDGTTEDGSAANGRLWRTVIIGEQEHRIDLHMI . :: : ::.. :. .. . . :.:. : ::::::.:::::.:::...: XP_005 H------ED--P--TANKDSGQESESIPEYTAEEEREDN-RLWRTVVIGEQEQRIDMKVI 2860 2870 2880 2890 2900 180 190 200 210 220 pF1KSD RPYMKVVTHGG---YYGEGLNAIIVFAACFLPDSSLPDYHYIMENLFLYVISSLELLVAE .:: .:..::: :::.::::::::::::::::: ::::.::::::::::.:::.::: XP_005 EPYRRVISHGGDSGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLYVISTLELMVAE 2910 2920 2930 2940 2950 2960 230 240 250 260 270 280 pF1KSD DYMIVYLNGATPRRRMPGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFI ::::::::::::::::::.::.:::::::::::::::::.:::::::::::.::..:::: XP_005 DYMIVYLNGATPRRRMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFI 2970 2980 2990 3000 3010 3020 290 300 310 320 330 340 pF1KSD SVKFINKIQYVHSLEDLEQLIPMEHVQIPDCVLQYEEERLKARRESARPQPEFVLPRSEE : :: .::.::.:: .: ::::. ..::. ...:.::: : : XP_005 SSKFSSKIKYVNSLSELSGLIPMDCIHIPESIIKYDEERSYKRSVSIDLKLKEKP 3030 3040 3050 3060 3070 350 360 370 pF1KSD KPEVAPVENRSALVSEDQETSMS >>XP_011516630 (OMIM: 610691) PREDICTED: protein prune h (3072 aa) initn: 1142 init1: 818 opt: 1245 Z-score: 1390.6 bits: 269.0 E(85289): 1e-70 Smith-Waterman score: 1269; 62.0% identity (82.1% similar) in 313 aa overlap (22-331:2763-3063) 10 20 30 40 50 pF1KSD MGTTEATLRMENVDVKEEWQDEDLPRPLPEETGVELLGSPVEDTSSPPNTL ::. .: : :: : : .. :::.: XP_011 KNMIPDTEMEEETEFLELGTRISRPNGLLSEDVGMDIPFEEGV-LSPSAADMRPEPPNSL 2740 2750 2760 2770 2780 2790 60 70 80 90 100 110 pF1KSD NFNGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLG ..: .: .: :.::.::.::::::::.:::: ::.::..:::::...::::.::.:. : XP_011 DLNDTHPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDEIDINVDELDTPDEADSFEYTG 2800 2810 2820 2830 2840 2850 120 130 140 150 160 170 pF1KSD NGNELEWEDDTPVATAKNMPGDSADLFGDGTTEDGSAANGRLWRTVIIGEQEHRIDLHMI . :: : ::.. :. .. . . :.:. : ::::::.:::::.:::...: XP_011 H------ED--P--TANKDSGQESESIPEYTAEEEREDN-RLWRTVVIGEQEQRIDMKVI 2860 2870 2880 2890 2900 180 190 200 210 220 pF1KSD RPYMKVVTHGG---YYGEGLNAIIVFAACFLPDSSLPDYHYIMENLFLYVISSLELLVAE .:: .:..::: :::.::::::::::::::::: ::::.::::::::::.:::.::: XP_011 EPYRRVISHGGDSGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLYVISTLELMVAE 2910 2920 2930 2940 2950 2960 230 240 250 260 270 280 pF1KSD DYMIVYLNGATPRRRMPGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFI ::::::::::::::::::.::.:::::::::::::::::.:::::::::::.::..:::: XP_011 DYMIVYLNGATPRRRMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFI 2970 2980 2990 3000 3010 3020 290 300 310 320 330 340 pF1KSD SVKFINKIQYVHSLEDLEQLIPMEHVQIPDCVLQYEEERLKARRESARPQPEFVLPRSEE : :: .::.::.:: .: ::::. ..::. ...:.::: : XP_011 SSKFSSKIKYVNSLSELSGLIPMDCIHIPESIIKYDEERSYKRSVRKLCCVH 3030 3040 3050 3060 3070 350 360 370 pF1KSD KPEVAPVENRSALVSEDQETSMS >>XP_005251803 (OMIM: 610691) PREDICTED: protein prune h (3091 aa) initn: 1143 init1: 819 opt: 1245 Z-score: 1390.6 bits: 269.0 E(85289): 1e-70 Smith-Waterman score: 1269; 62.0% identity (82.1% similar) in 313 aa overlap (22-331:2763-3063) 10 20 30 40 50 pF1KSD MGTTEATLRMENVDVKEEWQDEDLPRPLPEETGVELLGSPVEDTSSPPNTL ::. .: : :: : : .. :::.: XP_005 KNMIPDTEMEEETEFLELGTRISRPNGLLSEDVGMDIPFEEGV-LSPSAADMRPEPPNSL 2740 2750 2760 2770 2780 2790 60 70 80 90 100 110 pF1KSD NFNGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLG ..: .: .: :.::.::.::::::::.:::: ::.::..:::::...::::.::.:. : XP_005 DLNDTHPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDEIDINVDELDTPDEADSFEYTG 2800 2810 2820 2830 2840 2850 120 130 140 150 160 170 pF1KSD NGNELEWEDDTPVATAKNMPGDSADLFGDGTTEDGSAANGRLWRTVIIGEQEHRIDLHMI . :: : ::.. :. .. . . :.:. : ::::::.:::::.:::...: XP_005 H------ED--P--TANKDSGQESESIPEYTAEEEREDN-RLWRTVVIGEQEQRIDMKVI 2860 2870 2880 2890 2900 180 190 200 210 220 pF1KSD RPYMKVVTHGG---YYGEGLNAIIVFAACFLPDSSLPDYHYIMENLFLYVISSLELLVAE .:: .:..::: :::.::::::::::::::::: ::::.::::::::::.:::.::: XP_005 EPYRRVISHGGDSGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLYVISTLELMVAE 2910 2920 2930 2940 2950 2960 230 240 250 260 270 280 pF1KSD DYMIVYLNGATPRRRMPGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFI ::::::::::::::::::.::.:::::::::::::::::.:::::::::::.::..:::: XP_005 DYMIVYLNGATPRRRMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFI 2970 2980 2990 3000 3010 3020 290 300 310 320 330 340 pF1KSD SVKFINKIQYVHSLEDLEQLIPMEHVQIPDCVLQYEEERLKARRESARPQPEFVLPRSEE : :: .::.::.:: .: ::::. ..::. ...:.::: : XP_005 SSKFSSKIKYVNSLSELSGLIPMDCIHIPESIIKYDEERSYKRSVRTSCLYNDPEMSSME 3030 3040 3050 3060 3070 3080 350 360 370 pF1KSD KPEVAPVENRSALVSEDQETSMS XP_005 KDIDLKLKEKP 3090 >>XP_005251802 (OMIM: 610691) PREDICTED: protein prune h (3092 aa) initn: 1126 init1: 802 opt: 1235 Z-score: 1379.3 bits: 266.9 E(85289): 4.3e-70 Smith-Waterman score: 1259; 61.0% identity (81.8% similar) in 318 aa overlap (22-336:2763-3067) 10 20 30 40 50 pF1KSD MGTTEATLRMENVDVKEEWQDEDLPRPLPEETGVELLGSPVEDTSSPPNTL ::. .: : :: : : .. :::.: XP_005 KNMIPDTEMEEETEFLELGTRISRPNGLLSEDVGMDIPFEEGV-LSPSAADMRPEPPNSL 2740 2750 2760 2770 2780 2790 60 70 80 90 100 110 pF1KSD NFNGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLG ..: .: .: :.::.::.::::::::.:::: ::.::..:::::...::::.::.:. : XP_005 DLNDTHPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDEIDINVDELDTPDEADSFEYTG 2800 2810 2820 2830 2840 2850 120 130 140 150 160 170 pF1KSD NGNELEWEDDTPVATAKNMPGDSADLFGDGTTEDGSAANGRLWRTVIIGEQEHRIDLHMI . :: : ::.. :. .. . . :.:. : ::::::.:::::.:::...: XP_005 H------ED--P--TANKDSGQESESIPEYTAEEEREDN-RLWRTVVIGEQEQRIDMKVI 2860 2870 2880 2890 2900 180 190 200 210 220 pF1KSD RPYMKVVTHGG---YYGEGLNAIIVFAACFLPDSSLPDYHYIMENLFLYVISSLELLVAE .:: .:..::: :::.::::::::::::::::: ::::.::::::::::.:::.::: XP_005 EPYRRVISHGGDSGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLYVISTLELMVAE 2910 2920 2930 2940 2950 2960 230 240 250 260 270 280 pF1KSD DYMIVYLNGATPRRRMPGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFI ::::::::::::::::::.::.:::::::::::::::::.:::::::::::.::..:::: XP_005 DYMIVYLNGATPRRRMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFI 2970 2980 2990 3000 3010 3020 290 300 310 320 330 340 pF1KSD SVKFINKIQYVHSLEDLEQLIPMEHVQIPDCVLQYEEERLKARRESARPQPEFVLPRSEE : :: .::.::.:: .: ::::. ..::. ... .:: :. :.:. XP_005 SSKFSSKIKYVNSLSELSGLIPMDCIHIPESIIKLDEE-LREASEAAKTSCLYNDPEMSS 3030 3040 3050 3060 3070 350 360 370 pF1KSD KPEVAPVENRSALVSEDQETSMS XP_005 MEKDIDLKLKEKP 3080 3090 >>NP_001294977 (OMIM: 610691) protein prune homolog 2 is (3063 aa) initn: 1269 init1: 788 opt: 1215 Z-score: 1356.9 bits: 262.8 E(85289): 7.7e-69 Smith-Waterman score: 1239; 61.0% identity (81.8% similar) in 313 aa overlap (22-331:2763-3062) 10 20 30 40 50 pF1KSD MGTTEATLRMENVDVKEEWQDEDLPRPLPEETGVELLGSPVEDTSSPPNTL ::. .: : :: : : .. :::.: NP_001 KNMIPDTEMEEETEFLELGTRISRPNGLLSEDVGMDIPFEEGV-LSPSAADMRPEPPNSL 2740 2750 2760 2770 2780 2790 60 70 80 90 100 110 pF1KSD NFNGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLG ..: .: .: :.::.::.::::::::.:::: ::.::..:::::...::::.::.:. : NP_001 DLNDTHPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDEIDINVDELDTPDEADSFEYTG 2800 2810 2820 2830 2840 2850 120 130 140 150 160 170 pF1KSD NGNELEWEDDTPVATAKNMPGDSADLFGDGTTEDGSAANGRLWRTVIIGEQEHRIDLHMI . :: : ::.. :. .. . . :.:. : ::::::.:::::.:::...: NP_001 H------ED--P--TANKDSGQESESIPEYTAEEEREDN-RLWRTVVIGEQEQRIDMKVI 2860 2870 2880 2890 2900 180 190 200 210 220 pF1KSD RPYMKVVTHGG---YYGEGLNAIIVFAACFLPDSSLPDYHYIMENLFLYVISSLELLVAE .:: .:..::: :::.::::::::::::::::: ::::.::::::::::.:::.::: NP_001 EPYRRVISHGGDSGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLYVISTLELMVAE 2910 2920 2930 2940 2950 2960 230 240 250 260 270 280 pF1KSD DYMIVYLNGATPRRRMPGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFI ::::::::::::::::::.::.:::::::::::::::::.:::::::::::.::..:::: NP_001 DYMIVYLNGATPRRRMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFI 2970 2980 2990 3000 3010 3020 290 300 310 320 330 340 pF1KSD SVKFINKIQYVHSLEDLEQLIPMEHVQIPDCVLQYEEERLKARRESARPQPEFVLPRSEE : :: .::.::.:: .: ::::. ..::. ... . .:: . NP_001 SSKFSSKIKYVNSLSELSGLIPMDCIHIPESIINIDL-KLKEKP 3030 3040 3050 3060 350 360 370 pF1KSD KPEVAPVENRSALVSEDQETSMS >>XP_016869842 (OMIM: 610691) PREDICTED: protein prune h (3068 aa) initn: 1267 init1: 789 opt: 1215 Z-score: 1356.9 bits: 262.8 E(85289): 7.7e-69 Smith-Waterman score: 1239; 62.2% identity (82.6% similar) in 304 aa overlap (22-322:2763-3054) 10 20 30 40 50 pF1KSD MGTTEATLRMENVDVKEEWQDEDLPRPLPEETGVELLGSPVEDTSSPPNTL ::. .: : :: : : .. :::.: XP_016 KNMIPDTEMEEETEFLELGTRISRPNGLLSEDVGMDIPFEEGV-LSPSAADMRPEPPNSL 2740 2750 2760 2770 2780 2790 60 70 80 90 100 110 pF1KSD NFNGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLG ..: .: .: :.::.::.::::::::.:::: ::.::..:::::...::::.::.:. : XP_016 DLNDTHPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDEIDINVDELDTPDEADSFEYTG 2800 2810 2820 2830 2840 2850 120 130 140 150 160 170 pF1KSD NGNELEWEDDTPVATAKNMPGDSADLFGDGTTEDGSAANGRLWRTVIIGEQEHRIDLHMI . :: : ::.. :. .. . . :.:. : ::::::.:::::.:::...: XP_016 H------ED--P--TANKDSGQESESIPEYTAEEEREDN-RLWRTVVIGEQEQRIDMKVI 2860 2870 2880 2890 2900 180 190 200 210 220 pF1KSD RPYMKVVTHGG---YYGEGLNAIIVFAACFLPDSSLPDYHYIMENLFLYVISSLELLVAE .:: .:..::: :::.::::::::::::::::: ::::.::::::::::.:::.::: XP_016 EPYRRVISHGGDSGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLYVISTLELMVAE 2910 2920 2930 2940 2950 2960 230 240 250 260 270 280 pF1KSD DYMIVYLNGATPRRRMPGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFI ::::::::::::::::::.::.:::::::::::::::::.:::::::::::.::..:::: XP_016 DYMIVYLNGATPRRRMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFI 2970 2980 2990 3000 3010 3020 290 300 310 320 330 340 pF1KSD SVKFINKIQYVHSLEDLEQLIPMEHVQIPDCVLQYEEERLKARRESARPQPEFVLPRSEE : :: .::.::.:: .: ::::. ..::. ... XP_016 SSKFSSKIKYVNSLSELSGLIPMDCIHIPESIIKCRGRNLVGSYLCTV 3030 3040 3050 3060 350 360 370 pF1KSD KPEVAPVENRSALVSEDQETSMS 371 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 07:34:08 2016 done: Thu Nov 3 07:34:09 2016 Total Scan time: 8.720 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]