FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDA1950, 498 aa 1>>>pF1KSDA1950 498 - 498 aa - 498 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0506+/-0.000302; mu= 15.6856+/- 0.019 mean_var=101.8416+/-20.295, 0's: 0 Z-trim(119.4): 41 B-trim: 116 in 1/57 Lambda= 0.127090 statistics sampled from 33263 (33304) to 33263 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.745), E-opt: 0.2 (0.39), width: 16 Scan time: 10.860 The best scores are: opt bits E(85289) NP_597720 (OMIM: 615168) archaemetzincin-1 isoform ( 498) 3447 642.4 9e-184 XP_011513452 (OMIM: 615168) PREDICTED: archaemetzi ( 498) 3447 642.4 9e-184 NP_001308695 (OMIM: 615168) archaemetzincin-1 isof ( 330) 2204 414.3 2.7e-115 XP_016867265 (OMIM: 615168) PREDICTED: archaemetzi ( 273) 1773 335.2 1.4e-91 XP_016867264 (OMIM: 615168) PREDICTED: archaemetzi ( 298) 1389 264.8 2.4e-70 NP_001271284 (OMIM: 615168) archaemetzincin-1 isof ( 297) 1373 261.9 1.8e-69 XP_011513453 (OMIM: 615168) PREDICTED: archaemetzi ( 308) 1373 261.9 1.9e-69 XP_016867263 (OMIM: 615168) PREDICTED: archaemetzi ( 308) 1373 261.9 1.9e-69 NP_001333407 (OMIM: 615169) archaemetzincin-2 isof ( 360) 728 143.7 8.4e-34 NP_001333403 (OMIM: 615169) archaemetzincin-2 isof ( 360) 728 143.7 8.4e-34 NP_001028741 (OMIM: 615169) archaemetzincin-2 isof ( 360) 728 143.7 8.4e-34 NP_001333408 (OMIM: 615169) archaemetzincin-2 isof ( 360) 728 143.7 8.4e-34 NP_001028742 (OMIM: 615169) archaemetzincin-2 isof ( 360) 728 143.7 8.4e-34 NP_001333405 (OMIM: 615169) archaemetzincin-2 isof ( 360) 728 143.7 8.4e-34 NP_001333400 (OMIM: 615169) archaemetzincin-2 isof ( 360) 728 143.7 8.4e-34 NP_001333406 (OMIM: 615169) archaemetzincin-2 isof ( 360) 728 143.7 8.4e-34 NP_001333401 (OMIM: 615169) archaemetzincin-2 isof ( 360) 728 143.7 8.4e-34 NP_001333402 (OMIM: 615169) archaemetzincin-2 isof ( 360) 728 143.7 8.4e-34 NP_057711 (OMIM: 615169) archaemetzincin-2 isoform ( 360) 728 143.7 8.4e-34 NP_001275985 (OMIM: 615169) archaemetzincin-2 isof ( 360) 728 143.7 8.4e-34 NP_001333404 (OMIM: 615169) archaemetzincin-2 isof ( 360) 728 143.7 8.4e-34 NP_001028743 (OMIM: 615169) archaemetzincin-2 isof ( 360) 728 143.7 8.4e-34 NP_001275983 (OMIM: 615169) archaemetzincin-2 isof ( 360) 728 143.7 8.4e-34 NP_001028744 (OMIM: 615169) archaemetzincin-2 isof ( 360) 728 143.7 8.4e-34 XP_005257489 (OMIM: 615169) PREDICTED: archaemetzi ( 424) 728 143.8 9.5e-34 NP_001333414 (OMIM: 615169) archaemetzincin-2 isof ( 304) 665 132.1 2.2e-30 NP_001333411 (OMIM: 615169) archaemetzincin-2 isof ( 326) 568 114.3 5.2e-25 NP_001333410 (OMIM: 615169) archaemetzincin-2 isof ( 326) 568 114.3 5.2e-25 XP_006722003 (OMIM: 615169) PREDICTED: archaemetzi ( 326) 568 114.3 5.2e-25 NP_001333412 (OMIM: 615169) archaemetzincin-2 isof ( 326) 568 114.3 5.2e-25 NP_001333413 (OMIM: 615169) archaemetzincin-2 isof ( 326) 568 114.3 5.2e-25 NP_001028746 (OMIM: 615169) archaemetzincin-2 isof ( 302) 475 97.3 6.7e-20 NP_001333409 (OMIM: 615169) archaemetzincin-2 isof ( 302) 475 97.3 6.7e-20 >>NP_597720 (OMIM: 615168) archaemetzincin-1 isoform 1 [ (498 aa) initn: 3447 init1: 3447 opt: 3447 Z-score: 3420.2 bits: 642.4 E(85289): 9e-184 Smith-Waterman score: 3447; 100.0% identity (100.0% similar) in 498 aa overlap (1-498:1-498) 10 20 30 40 50 60 pF1KSD MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_597 MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_597 RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_597 EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD SDLYPHEAWSFTFSKFLPGHEVGVCSFARFSGEFPKSGPSAPDLALVEAAADGPEAPLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_597 SDLYPHEAWSFTFSKFLPGHEVGVCSFARFSGEFPKSGPSAPDLALVEAAADGPEAPLQD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD RGWALCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALSLDEALRRPLDLCPICL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_597 RGWALCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALSLDEALRRPLDLCPICL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD RKLQHVLGFRLIERYQRLYTWTQAVVGTWPSQEAGEPSVWEDTPPASADSGMCCESDSEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_597 RKLQHVLGFRLIERYQRLYTWTQAVVGTWPSQEAGEPSVWEDTPPASADSGMCCESDSEP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GTSVSEPLTPDAGSHTFASGPEEGLSYLAASEAPLPPGGPAEAIKEHERWLAMCIQALQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_597 GTSVSEPLTPDAGSHTFASGPEEGLSYLAASEAPLPPGGPAEAIKEHERWLAMCIQALQR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD EVAEEDLVQVDRAVDALDRWEMFTGQLPATRQDPPSSRDSVGLRKVLGDKFSSLRRKLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_597 EVAEEDLVQVDRAVDALDRWEMFTGQLPATRQDPPSSRDSVGLRKVLGDKFSSLRRKLSA 430 440 450 460 470 480 490 pF1KSD RKLARAESAPRPWDGEES :::::::::::::::::: NP_597 RKLARAESAPRPWDGEES 490 >>XP_011513452 (OMIM: 615168) PREDICTED: archaemetzincin (498 aa) initn: 3447 init1: 3447 opt: 3447 Z-score: 3420.2 bits: 642.4 E(85289): 9e-184 Smith-Waterman score: 3447; 100.0% identity (100.0% similar) in 498 aa overlap (1-498:1-498) 10 20 30 40 50 60 pF1KSD MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD SDLYPHEAWSFTFSKFLPGHEVGVCSFARFSGEFPKSGPSAPDLALVEAAADGPEAPLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDLYPHEAWSFTFSKFLPGHEVGVCSFARFSGEFPKSGPSAPDLALVEAAADGPEAPLQD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD RGWALCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALSLDEALRRPLDLCPICL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGWALCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALSLDEALRRPLDLCPICL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD RKLQHVLGFRLIERYQRLYTWTQAVVGTWPSQEAGEPSVWEDTPPASADSGMCCESDSEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKLQHVLGFRLIERYQRLYTWTQAVVGTWPSQEAGEPSVWEDTPPASADSGMCCESDSEP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD GTSVSEPLTPDAGSHTFASGPEEGLSYLAASEAPLPPGGPAEAIKEHERWLAMCIQALQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTSVSEPLTPDAGSHTFASGPEEGLSYLAASEAPLPPGGPAEAIKEHERWLAMCIQALQR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD EVAEEDLVQVDRAVDALDRWEMFTGQLPATRQDPPSSRDSVGLRKVLGDKFSSLRRKLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVAEEDLVQVDRAVDALDRWEMFTGQLPATRQDPPSSRDSVGLRKVLGDKFSSLRRKLSA 430 440 450 460 470 480 490 pF1KSD RKLARAESAPRPWDGEES :::::::::::::::::: XP_011 RKLARAESAPRPWDGEES 490 >>NP_001308695 (OMIM: 615168) archaemetzincin-1 isoform (330 aa) initn: 2198 init1: 2198 opt: 2204 Z-score: 2191.0 bits: 414.3 E(85289): 2.7e-115 Smith-Waterman score: 2204; 97.8% identity (98.8% similar) in 325 aa overlap (1-325:1-323) 10 20 30 40 50 60 pF1KSD MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD SDLYPHEAWSFTFSKFLPGHEVGVCSFARFSGEFPKSGPSAPDLALVEAAADGPEAPLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDLYPHEAWSFTFSKFLPGHEVGVCSFARFSGEFPKSGPSAPDLALVEAAADGPEAPLQD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD RGWALCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALSLDEALRRPLDLCPICL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGWALCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALSLDEALRRPLDLCPICL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD RKLQHVLGFRLIERYQRLYTWTQAVVGTWPSQEAGEPSVWEDTPPASADSGMCCESDSEP :::::::::::::::: .:.. : NP_001 RKLQHVLGFRLIERYQ--VSWVNPVASATAGN 310 320 330 >>XP_016867265 (OMIM: 615168) PREDICTED: archaemetzincin (273 aa) initn: 1773 init1: 1773 opt: 1773 Z-score: 1765.1 bits: 335.2 E(85289): 1.4e-91 Smith-Waterman score: 1773; 100.0% identity (100.0% similar) in 258 aa overlap (1-258:1-258) 10 20 30 40 50 60 pF1KSD MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD SDLYPHEAWSFTFSKFLPGHEVGVCSFARFSGEFPKSGPSAPDLALVEAAADGPEAPLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDLYPHEAWSFTFSKFLPGHEVGVCSFARFSGEFPKSGPSAPDLALVEAAADGPEAPLQD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD RGWALCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALSLDEALRRPLDLCPICL :::::::::::::::::: XP_016 RGWALCFSALGMVQCCKVGGGSGAGKRGQEGAV 250 260 270 >>XP_016867264 (OMIM: 615168) PREDICTED: archaemetzincin (298 aa) initn: 1361 init1: 1361 opt: 1389 Z-score: 1384.0 bits: 264.8 E(85289): 2.4e-70 Smith-Waterman score: 1389; 85.1% identity (89.6% similar) in 249 aa overlap (1-245:1-249) 10 20 30 40 50 60 pF1KSD MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL 130 140 150 160 170 180 190 200 210 220 230 pF1KSD SDLYPHEAWSFTFSKFLPGH-EVG---VCSFARFSGEFPKSGPSAPDLALVEAAADGPEA :::::::::::::::::::: : : .: . .. : ::.: :..: . . XP_016 SDLYPHEAWSFTFSKFLPGHGEPGPQQLCVGGSLAWGCGLRGCRAPSLLLLQAPSWWKST 190 200 210 220 230 240 240 250 260 270 280 290 pF1KSD PLQDRGWALCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALSLDEALRRPLDLC :.. : : XP_016 PVHGNRWPLPAPPEEWHRGCSSAVASAPGPNFMWAGQGLPGLVCLWAMASLHESMRWV 250 260 270 280 290 >>NP_001271284 (OMIM: 615168) archaemetzincin-1 isoform (297 aa) initn: 1406 init1: 1361 opt: 1373 Z-score: 1368.2 bits: 261.9 E(85289): 1.8e-69 Smith-Waterman score: 1381; 73.3% identity (78.7% similar) in 315 aa overlap (1-307:1-297) 10 20 30 40 50 60 pF1KSD MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL 130 140 150 160 170 180 190 200 210 220 230 pF1KSD SDLYPHEAWSFTFSKFLPGH-EVGVCSFARFSGEFP-----KSGPSAPDLALVEAAADGP :::::::::::::::::::: .: ::.: ..: . : . ::: :: NP_001 SDLYPHEAWSFTFSKFLPGHGHVPRALPPSGPGELPLAPLPHAGCAQPGRG--PAAAPGP 190 200 210 220 230 240 250 260 270 280 290 pF1KSD EAPLQDRGWALC--FSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALSLDEALRRP . : ... : : :.: : : :: . :. . ::.:. NP_001 LSHLPEEA-AACPGFQAHREVP-------ETLHLDSGGGGDVAQPGGGGAVSVGGH---- 240 250 260 270 280 300 310 320 330 340 350 pF1KSD LDLCPICLRKLQHVLGFRLIERYQRLYTWTQAVVGTWPSQEAGEPSVWEDTPPASADSGM : : :.: ::: NP_001 ----PACQRRLGHVL 290 >>XP_011513453 (OMIM: 615168) PREDICTED: archaemetzincin (308 aa) initn: 1406 init1: 1361 opt: 1373 Z-score: 1368.0 bits: 261.9 E(85289): 1.9e-69 Smith-Waterman score: 1373; 84.9% identity (88.9% similar) in 252 aa overlap (1-246:1-249) 10 20 30 40 50 60 pF1KSD MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL 130 140 150 160 170 180 190 200 210 220 230 pF1KSD SDLYPHEAWSFTFSKFLPGH-EVGVCSFARFSGEFP-----KSGPSAPDLALVEAAADGP :::::::::::::::::::: .: ::.: ..: . : . ::: :: XP_011 SDLYPHEAWSFTFSKFLPGHGHVPRALPPSGPGELPLAPLPHAGCAQPGRG--PAAAPGP 190 200 210 220 230 240 250 260 270 280 290 pF1KSD EAPLQDRGWALCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALSLDEALRRPLD . : ... : : XP_011 LSHLPEEA-AACPGFQAHREVPGELGEPSSFSHSWELKQHLKSLSFSQREPADPEGNTET 240 250 260 270 280 290 >>XP_016867263 (OMIM: 615168) PREDICTED: archaemetzincin (308 aa) initn: 1406 init1: 1361 opt: 1373 Z-score: 1368.0 bits: 261.9 E(85289): 1.9e-69 Smith-Waterman score: 1373; 84.9% identity (88.9% similar) in 252 aa overlap (1-246:1-249) 10 20 30 40 50 60 pF1KSD MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPIDLSEEPVGSSLLHQLCSCT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGLTL 130 140 150 160 170 180 190 200 210 220 230 pF1KSD SDLYPHEAWSFTFSKFLPGH-EVGVCSFARFSGEFP-----KSGPSAPDLALVEAAADGP :::::::::::::::::::: .: ::.: ..: . : . ::: :: XP_016 SDLYPHEAWSFTFSKFLPGHGHVPRALPPSGPGELPLAPLPHAGCAQPGRG--PAAAPGP 190 200 210 220 230 240 250 260 270 280 290 pF1KSD EAPLQDRGWALCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALSLDEALRRPLD . : ... : : XP_016 LSHLPEEA-AACPGFQAHREVPGELGEPSSFSHSWELKQHLKSLSFSQREPADPEGNTET 240 250 260 270 280 290 >>NP_001333407 (OMIM: 615169) archaemetzincin-2 isoform (360 aa) initn: 654 init1: 300 opt: 728 Z-score: 727.9 bits: 143.7 E(85289): 8.4e-34 Smith-Waterman score: 728; 36.9% identity (68.6% similar) in 309 aa overlap (15-321:9-314) 10 20 30 40 50 60 pF1KSD MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI ..:: ::.: . .: . : .. .:. .. ::..: :: . . NP_001 MQIIRHSEQTLKTALISKNPVLVSQY-EKLNAGEQRLMNEAFQPASDLFGPITL 10 20 30 40 50 70 80 90 100 110 pF1KSD RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPI-DLSEEPVGSS-LLHQLCS .. ::. :.::::.::. : .. .. : .. ::.: : .:.. . : .. : . NP_001 HSPSDWITSHPEAPQDFEQFFSDPYRKTPSPNKRSIYIQSIGSLGNTRIISEEYIKWLTG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KSD CTEAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGL .:.: ::::: : : .. ::: : .... ::.:. ::.:::..:: ::.::.:. NP_001 YCKAYFYGLRVKLLEPVPVSVTRCSFRVNENTHNLQIHAGDILKFLKKKKPEDAFCVVGI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KSD TLSDLYPHEAWSFTFSKFLPGHEVGVCSFARFSGEFPKSGPSAPDLALVEAAADGPEAPL :. ::::...:.:.:.. ::. ::::....: . .. : ..... . . NP_001 TMIDLYPRDSWNFVFGQASLTDGVGIFSFARYGSDFYSMHYKGKVKKLKKTSSS--DYSI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KSD QDRGWALCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALSLDEALRRPLDLCPI : . .... ... ::. ::. :..:: .:.:: :::::. :.:: ::::.:::: NP_001 FDNYYIPEITSVLLLRSCKTLTHEIGHIFGLRHCQWLACLMQGSNHLEEADRRPLNLCPI 240 250 260 270 280 290 300 310 320 330 340 350 pF1KSD CLRKLQHVLGFRLIERYQRLYTWTQAVVGTWPSQEAGEPSVWEDTPPASADSGMCCESDS ::.::: ..:: ..:::. : : NP_001 CLHKLQCAVGFSIVERYKALVRWIDDESSDTPGATPEHSHEDNGNLPKPVEAFKEWKEWI 300 310 320 330 340 350 >>NP_001333403 (OMIM: 615169) archaemetzincin-2 isoform (360 aa) initn: 654 init1: 300 opt: 728 Z-score: 727.9 bits: 143.7 E(85289): 8.4e-34 Smith-Waterman score: 728; 36.9% identity (68.6% similar) in 309 aa overlap (15-321:9-314) 10 20 30 40 50 60 pF1KSD MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFLAEAYNPQRTLFCTLLI ..:: ::.: . .: . : .. .:. .. ::..: :: . . NP_001 MQIIRHSEQTLKTALISKNPVLVSQY-EKLNAGEQRLMNEAFQPASDLFGPITL 10 20 30 40 50 70 80 90 100 110 pF1KSD RTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPI-DLSEEPVGSS-LLHQLCS .. ::. :.::::.::. : .. .. : .. ::.: : .:.. . : .. : . NP_001 HSPSDWITSHPEAPQDFEQFFSDPYRKTPSPNKRSIYIQSIGSLGNTRIISEEYIKWLTG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KSD CTEAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGILSFLKNNKPGDALCVLGL .:.: ::::: : : .. ::: : .... ::.:. ::.:::..:: ::.::.:. NP_001 YCKAYFYGLRVKLLEPVPVSVTRCSFRVNENTHNLQIHAGDILKFLKKKKPEDAFCVVGI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KSD TLSDLYPHEAWSFTFSKFLPGHEVGVCSFARFSGEFPKSGPSAPDLALVEAAADGPEAPL :. ::::...:.:.:.. ::. ::::....: . .. : ..... . . NP_001 TMIDLYPRDSWNFVFGQASLTDGVGIFSFARYGSDFYSMHYKGKVKKLKKTSSS--DYSI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KSD QDRGWALCFSALGMVQCCKVTCHELCHLLGLGNCRWLRCLMQGALSLDEALRRPLDLCPI : . .... ... ::. ::. :..:: .:.:: :::::. :.:: ::::.:::: NP_001 FDNYYIPEITSVLLLRSCKTLTHEIGHIFGLRHCQWLACLMQGSNHLEEADRRPLNLCPI 240 250 260 270 280 290 300 310 320 330 340 350 pF1KSD CLRKLQHVLGFRLIERYQRLYTWTQAVVGTWPSQEAGEPSVWEDTPPASADSGMCCESDS ::.::: ..:: ..:::. : : NP_001 CLHKLQCAVGFSIVERYKALVRWIDDESSDTPGATPEHSHEDNGNLPKPVEAFKEWKEWI 300 310 320 330 340 350 498 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 19:13:46 2016 done: Thu Nov 3 19:13:48 2016 Total Scan time: 10.860 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]