Result of FASTA (omim) for
pF1KSDA1971
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1971, 809 aa
1>>>pF1KSDA1971 809 - 809 aa - 809 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 13.9367+/-0.000454; mu= -18.1352+/- 0.028
mean_var=544.4237+/-112.693, 0's: 0 Z-trim(123.1): 28 B-trim: 177 in 1/57
Lambda= 0.054967
statistics sampled from 42177 (42213) to 42177 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.773), E-opt: 0.2 (0.495), width: 16
Scan time: 13.910
The best scores are: opt bits E(85289)
NP_001073904 (OMIM: 612393) WASP homolog-associate ( 809) 5492 450.7 1.2e-125
XP_005272478 (OMIM: 612393) PREDICTED: WASP homolo ( 596) 3984 331.0 9.2e-90
XP_005272479 (OMIM: 612393) PREDICTED: WASP homolo ( 579) 3697 308.3 6.4e-83
XP_005272480 (OMIM: 612393) PREDICTED: WASP homolo ( 579) 3697 308.3 6.4e-83
XP_011519534 (OMIM: 612393) PREDICTED: WASP homolo ( 536) 3375 282.7 2.9e-75
XP_016877412 (OMIM: 612393) PREDICTED: WASP homolo ( 507) 3263 273.8 1.3e-72
XP_005248487 (OMIM: 604279) PREDICTED: junction-me ( 947) 1434 129.0 9.8e-29
XP_011541457 (OMIM: 604279) PREDICTED: junction-me ( 956) 1239 113.5 4.4e-24
NP_689618 (OMIM: 604279) junction-mediating and -r ( 988) 1177 108.6 1.4e-22
>>NP_001073904 (OMIM: 612393) WASP homolog-associated pr (809 aa)
initn: 5492 init1: 5492 opt: 5492 Z-score: 2377.0 bits: 450.7 E(85289): 1.2e-125
Smith-Waterman score: 5492; 100.0% identity (100.0% similar) in 809 aa overlap (1-809:1-809)
10 20 30 40 50 60
pF1KSD MEDEQPDSLEGWVPVREGLFAEPERHRLRFLVAWNGAEGKFAVTCHDRTAQQRRLREGAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDEQPDSLEGWVPVREGLFAEPERHRLRFLVAWNGAEGKFAVTCHDRTAQQRRLREGAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LGPEPEPKPEAAVSPSSWAGLLSAAGLRGAHRQLAALWPPLERCFPRLPPELDVGGGGAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGPEPEPKPEAAVSPSSWAGLLSAAGLRGAHRQLAALWPPLERCFPRLPPELDVGGGGAW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD GLGLGLWALLWPTRAGPGEAALQELCGQLERYLGAAADGCGGATVRDALFPAEGGAADCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLGLGLWALLWPTRAGPGEAALQELCGQLERYLGAAADGCGGATVRDALFPAEGGAADCE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD SPREFRERALRARWVEADARLRQVIQGHGKANTMVALMNVYQEEDEAYQELVTVATMFFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPREFRERALRARWVEADARLRQVIQGHGKANTMVALMNVYQEEDEAYQELVTVATMFFQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD YLLQPFRAMREVATLCKLDILKSLDEDDLGPRRVVALEKEAEEWTRRAEEAVVSIQDITV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLLQPFRAMREVATLCKLDILKSLDEDDLGPRRVVALEKEAEEWTRRAEEAVVSIQDITV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD NYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKELCLNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKELCLNH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LIKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD SLRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD RLRSFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLRSFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD AGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPPPPPPPPPPPLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPPPPPPPPPPPLR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD ALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLESFSCPGSMDEVLASLRHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLESFSCPGSMDEVLASLRHG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD RAPLRKVEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAPLRKVEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERS
730 740 750 760 770 780
790 800
pF1KSD IKAALQRIKRVSADSEEDSDEQDPGQWDG
:::::::::::::::::::::::::::::
NP_001 IKAALQRIKRVSADSEEDSDEQDPGQWDG
790 800
>>XP_005272478 (OMIM: 612393) PREDICTED: WASP homolog-as (596 aa)
initn: 3984 init1: 3984 opt: 3984 Z-score: 1732.5 bits: 331.0 E(85289): 9.2e-90
Smith-Waterman score: 3984; 100.0% identity (100.0% similar) in 596 aa overlap (214-809:1-596)
190 200 210 220 230 240
pF1KSD EFRERALRARWVEADARLRQVIQGHGKANTMVALMNVYQEEDEAYQELVTVATMFFQYLL
::::::::::::::::::::::::::::::
XP_005 MVALMNVYQEEDEAYQELVTVATMFFQYLL
10 20 30
250 260 270 280 290 300
pF1KSD QPFRAMREVATLCKLDILKSLDEDDLGPRRVVALEKEAEEWTRRAEEAVVSIQDITVNYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPFRAMREVATLCKLDILKSLDEDDLGPRRVVALEKEAEEWTRRAEEAVVSIQDITVNYF
40 50 60 70 80 90
310 320 330 340 350 360
pF1KSD KETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKELCLNHKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKELCLNHKRA
100 110 120 130 140 150
370 380 390 400 410 420
pF1KSD EIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKRLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKRLIK
160 170 180 190 200 210
430 440 450 460 470 480
pF1KSD EKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRASLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRASLR
220 230 240 250 260 270
490 500 510 520 530 540
pF1KSD SRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQRLR
280 290 300 310 320 330
550 560 570 580 590 600
pF1KSD SFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSEAGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSEAGN
340 350 360 370 380 390
610 620 630 640 650 660
pF1KSD VKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPPPPPPPPPPPLRALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPPPPPPPPPPPPPPPPPLRALS
400 410 420 430 440 450
670 680 690 700 710 720
pF1KSD SSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLESFSCPGSMDEVLASLRHGRAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLESFSCPGSMDEVLASLRHGRAP
460 470 480 490 500 510
730 740 750 760 770 780
pF1KSD LRKVEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERSIKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRKVEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERSIKA
520 530 540 550 560 570
790 800
pF1KSD ALQRIKRVSADSEEDSDEQDPGQWDG
::::::::::::::::::::::::::
XP_005 ALQRIKRVSADSEEDSDEQDPGQWDG
580 590
>>XP_005272479 (OMIM: 612393) PREDICTED: WASP homolog-as (579 aa)
initn: 3691 init1: 3691 opt: 3697 Z-score: 1609.7 bits: 308.3 E(85289): 6.4e-83
Smith-Waterman score: 3697; 99.3% identity (99.6% similar) in 556 aa overlap (255-809:24-579)
230 240 250 260 270 280
pF1KSD DEAYQELVTVATMFFQYLLQPFRAMREVATLC-KLDILKSLDEDDLGPRRVVALEKEAEE
:: ::.. ::::::::::::::::::::::
XP_005 MKHTRNWLPWQPCSSSTYCSHLGLCEKLQLYKSLDEDDLGPRRVVALEKEAEE
10 20 30 40 50
290 300 310 320 330 340
pF1KSD WTRRAEEAVVSIQDITVNYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WTRRAEEAVVSIQDITVNYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLML
60 70 80 90 100 110
350 360 370 380 390 400
pF1KSD ARETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEI
120 130 140 150 160 170
410 420 430 440 450 460
pF1KSD LKNEEILLTTQLDSLKRLIKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKNEEILLTTQLDSLKRLIKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRR
180 190 200 210 220 230
470 480 490 500 510 520
pF1KSD QCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEE
240 250 260 270 280 290
530 540 550 560 570 580
pF1KSD EQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAV
300 310 320 330 340 350
590 600 610 620 630 640
pF1KSD SVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPP
360 370 380 390 400 410
650 660 670 680 690 700
pF1KSD PPPPPPPPPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPPPPPPPPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLES
420 430 440 450 460 470
710 720 730 740 750 760
pF1KSD FSCPGSMDEVLASLRHGRAPLRKVEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLGPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSCPGSMDEVLASLRHGRAPLRKVEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLGPN
480 490 500 510 520 530
770 780 790 800
pF1KSD PSSKPTSNRRTSDLERSIKAALQRIKRVSADSEEDSDEQDPGQWDG
::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSSKPTSNRRTSDLERSIKAALQRIKRVSADSEEDSDEQDPGQWDG
540 550 560 570
>>XP_005272480 (OMIM: 612393) PREDICTED: WASP homolog-as (579 aa)
initn: 3691 init1: 3691 opt: 3697 Z-score: 1609.7 bits: 308.3 E(85289): 6.4e-83
Smith-Waterman score: 3697; 99.3% identity (99.6% similar) in 556 aa overlap (255-809:24-579)
230 240 250 260 270 280
pF1KSD DEAYQELVTVATMFFQYLLQPFRAMREVATLC-KLDILKSLDEDDLGPRRVVALEKEAEE
:: ::.. ::::::::::::::::::::::
XP_005 MKHTRNWLPWQPCSSSTYCSHLGLCEKLQLYKSLDEDDLGPRRVVALEKEAEE
10 20 30 40 50
290 300 310 320 330 340
pF1KSD WTRRAEEAVVSIQDITVNYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WTRRAEEAVVSIQDITVNYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLML
60 70 80 90 100 110
350 360 370 380 390 400
pF1KSD ARETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEI
120 130 140 150 160 170
410 420 430 440 450 460
pF1KSD LKNEEILLTTQLDSLKRLIKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKNEEILLTTQLDSLKRLIKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRR
180 190 200 210 220 230
470 480 490 500 510 520
pF1KSD QCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEE
240 250 260 270 280 290
530 540 550 560 570 580
pF1KSD EQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSGSEPVAPNLPSDLSQQMCLPASHAV
300 310 320 330 340 350
590 600 610 620 630 640
pF1KSD SVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGNIPVQVFVPVGDQTHSKSSEELSLPPPPP
360 370 380 390 400 410
650 660 670 680 690 700
pF1KSD PPPPPPPPPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPPPPPPPPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPRPLVCESPAERPRDSLES
420 430 440 450 460 470
710 720 730 740 750 760
pF1KSD FSCPGSMDEVLASLRHGRAPLRKVEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLGPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSCPGSMDEVLASLRHGRAPLRKVEVPAVRPPHASINEHILAAIRQGVKLKKVHPDLGPN
480 490 500 510 520 530
770 780 790 800
pF1KSD PSSKPTSNRRTSDLERSIKAALQRIKRVSADSEEDSDEQDPGQWDG
::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSSKPTSNRRTSDLERSIKAALQRIKRVSADSEEDSDEQDPGQWDG
540 550 560 570
>>XP_011519534 (OMIM: 612393) PREDICTED: WASP homolog-as (536 aa)
initn: 3369 init1: 3369 opt: 3375 Z-score: 1472.2 bits: 282.7 E(85289): 2.9e-75
Smith-Waterman score: 3375; 97.7% identity (98.6% similar) in 513 aa overlap (297-809:25-536)
270 280 290 300 310 320
pF1KSD DDLGPRRVVALEKEAEEWTRRAEEAVVSIQDITVNYFKETVKALAGMQKEMEQDAKRFGQ
. .: .:. . : :::::::::::::::
XP_011 MMILVLWSNYPYEPVCLARHRNNMEASVPKYKKQLPQL-GMQKEMEQDAKRFGQ
10 20 30 40 50
330 340 350 360 370 380
pF1KSD AAWATAIPRLEKLQLMLARETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNTNVVDELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAWATAIPRLEKLQLMLARETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNTNVVDELE
60 70 80 90 100 110
390 400 410 420 430 440
pF1KSD IQFYEIQLELYEVKFEILKNEEILLTTQLDSLKRLIKEKQDEVVYYDPCENPEELKVIDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQFYEIQLELYEVKFEILKNEEILLTTQLDSLKRLIKEKQDEVVYYDPCENPEELKVIDC
120 130 140 150 160 170
450 460 470 480 490 500
pF1KSD VVGLQDDKNLEVKELRRQCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQAEESIRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVGLQDDKNLEVKELRRQCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQAEESIRY
180 190 200 210 220 230
510 520 530 540 550 560
pF1KSD SRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSGSEPVAPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSGSEPVAPN
240 250 260 270 280 290
570 580 590 600 610 620
pF1KSD LPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGNIPVQVFVPVGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPSDLSQQMCLPASHAVSVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGNIPVQVFVPVGD
300 310 320 330 340 350
630 640 650 660 670 680
pF1KSD QTHSKSSEELSLPPPPPPPPPPPPPPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTHSKSSEELSLPPPPPPPPPPPPPPPPPPPPLRALSSSSQAATHQNLGFRAPVKDDQPR
360 370 380 390 400 410
690 700 710 720 730 740
pF1KSD PLVCESPAERPRDSLESFSCPGSMDEVLASLRHGRAPLRKVEVPAVRPPHASINEHILAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLVCESPAERPRDSLESFSCPGSMDEVLASLRHGRAPLRKVEVPAVRPPHASINEHILAA
420 430 440 450 460 470
750 760 770 780 790 800
pF1KSD IRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERSIKAALQRIKRVSADSEEDSDEQDPGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERSIKAALQRIKRVSADSEEDSDEQDPGQ
480 490 500 510 520 530
pF1KSD WDG
:::
XP_011 WDG
>>XP_016877412 (OMIM: 612393) PREDICTED: WASP homolog-as (507 aa)
initn: 3257 init1: 3257 opt: 3263 Z-score: 1424.5 bits: 273.8 E(85289): 1.3e-72
Smith-Waterman score: 3263; 99.6% identity (99.6% similar) in 489 aa overlap (1-489:1-489)
10 20 30 40 50 60
pF1KSD MEDEQPDSLEGWVPVREGLFAEPERHRLRFLVAWNGAEGKFAVTCHDRTAQQRRLREGAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEDEQPDSLEGWVPVREGLFAEPERHRLRFLVAWNGAEGKFAVTCHDRTAQQRRLREGAR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD LGPEPEPKPEAAVSPSSWAGLLSAAGLRGAHRQLAALWPPLERCFPRLPPELDVGGGGAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGPEPEPKPEAAVSPSSWAGLLSAAGLRGAHRQLAALWPPLERCFPRLPPELDVGGGGAW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD GLGLGLWALLWPTRAGPGEAALQELCGQLERYLGAAADGCGGATVRDALFPAEGGAADCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLGLGLWALLWPTRAGPGEAALQELCGQLERYLGAAADGCGGATVRDALFPAEGGAADCE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD SPREFRERALRARWVEADARLRQVIQGHGKANTMVALMNVYQEEDEAYQELVTVATMFFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPREFRERALRARWVEADARLRQVIQGHGKANTMVALMNVYQEEDEAYQELVTVATMFFQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD YLLQPFRAMREVATLCKLDILKSLDEDDLGPRRVVALEKEAEEWTRRAEEAVVSIQDITV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLLQPFRAMREVATLCKLDILKSLDEDDLGPRRVVALEKEAEEWTRRAEEAVVSIQDITV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD NYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKELCLNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NYFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKELCLNH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD KRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LIKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD SLRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQ
:::::: :
XP_016 SLRSRKVICIIPPGSVQRKSSVQIATG
490 500
>>XP_005248487 (OMIM: 604279) PREDICTED: junction-mediat (947 aa)
initn: 1656 init1: 1073 opt: 1434 Z-score: 636.9 bits: 129.0 E(85289): 9.8e-29
Smith-Waterman score: 1582; 37.1% identity (65.8% similar) in 766 aa overlap (63-808:214-946)
40 50 60 70 80 90
pF1KSD AWNGAEGKFAVTCHDRTAQQRRLREGARLGPEPEPKPEAAVSPSSWAGLLSAAGLRGAHR
: : . :. . :::::.: ::..:.
XP_005 SASGTVSEEIEVLEMVKEDEAPLALSDAEQPPPATELESPAEECSWAGLFSFQDLRAVHQ
190 200 210 220 230 240
100 110 120 130 140 150
pF1KSD QLAALWPPLERCFPRLPPELDVGGGGAWGLGLGLWALLWPTRAGPGEAALQELCGQLERY
:: .. :: :.: .: : . :.:..:. : .. :: ::. :
XP_005 QLCSVNSQLEPCLPVFPEEPS-----------GMWTVLFGGAPEMTEQEIDTLCYQLQVY
250 260 270 280 290
160 170 180 190 200 210
pF1KSD LGAAADGCGGATVRDALFPAEGGAADC-ESPREFRERALRARWVEADARLRQVIQGHGKA
:: . : :: . ..:: . :: :.:... . .: :...... : ..
XP_005 LGHGLDTCGWKILSQVLFTETDDPEEYYESLSELRQKGYEEVLQRARKRIQELLDKHKNT
300 310 320 330 340 350
220 230 240 250 260 270
pF1KSD NTMVALMNVYQEEDEAYQELVTVATMFFQYLLQPFRAMREVATLCKLDILKSLDEDDLGP
..:: :...:: :::::. :. ..: ..:::::::: :::.: : . .: :...: :::
XP_005 ESMVELLDLYQMEDEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGP
360 370 380 390 400 410
280 290 300 310 320 330
pF1KSD RRVVALEKEAEEWTRRAEEAVVSIQDITVNYFKETVKALAGMQKEMEQDAKRFGQAAWAT
::. .:.:: .: :.:. ::.::::.::.::. :.:: .. .:. : :.::.:.::.
XP_005 RRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAA
420 430 440 450 460 470
340 350 360 370 380 390
pF1KSD AIPRLEKLQLMLARETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNTNVVDELEIQFYE
: :.:::: ...::::.:::::.::.... .. .:..: . .:.:: ..:.
XP_005 AAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYD
480 490 500 510 520 530
400 410 420 430 440 450
pF1KSD IQLELYEVKFEILKNEEILLTTQLDSLKRLIKEKQDEVVYYDPCENPEELKVIDCVVGLQ
.::.::::.::::: ::.:::.::.:.::::.::.::::::: :. : . . ...
XP_005 LQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASA
540 550 560 570 580 590
460 470 480 490 500 510
pF1KSD DDKNLEVKELRRQCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQAEESIRYSRQHH
. :...:... .:::..:::. ::.. ::..:. : .: ..:: . : ::
XP_005 YLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHH
600 610 620 630 640 650
520 530 540 550 560 570
pF1KSD SIQMKRDKIKEEEQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSGSEPVAPNLPSDL
..:.::.:...::..:. :..::::.::.:::.:: .. ...... .: . ::.
XP_005 TVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFK--QVEEKTEEV--GEGRVKRGPSQT
660 670 680 690 700
580 590 600 610 620 630
pF1KSD SQQMCLPASHAVSVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGNIPVQVFVPVGDQTHSK
.. . : . .:. .. .. ..::: .: : ..: . .:. ...
XP_005 TEPQSLVQLEDTSL---TQLEATSLPLS---GVTS--------ELPPTISLPLLNNNLEP
710 720 730 740 750
640 650 660 670 680
pF1KSD SS---EELSLPPPPPPPPPPPPPPPPPPPPLRALSSSSQAATHQNLGF------RAPVKD
: . : : :: :::::::::::::::: . ..:. . ...: : : .
XP_005 CSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPETLEKDLPRKEGNEKRIPKSA
760 770 780 790 800 810
690 700 710 720 730
pF1KSD DQPRPLVCESP---AERPR-----DSLESFSCPGSMDEVLASLRHGRAPLRKVEVPAVRP
. : . .: . : . ..:. . ::::::::..: :.::: .. :
XP_005 SAPSAHLFDSSQLVSARKKLRKTAEGLQRRRVSSPMDEVLASLKRGSFHLKKVEQRTLPP
820 830 840 850 860 870
740 750 760 770 780 790
pF1KSD -PHASINEHILAAIRQGVKLKKVHPD-LGPNPSSKPTSNRRTSDLERSIKAALQRIKRVS
: . ...::: ::.:::::::. : : . . : :. : :::. ::.:::..:
XP_005 FPDEDDSNNILAQIRKGVKLKKVQKDVLRESFTLLPD----TDPLTRSIHEALRRIKEAS
880 890 900 910 920 930
800
pF1KSD ADSEEDSDEQDPGQWDG
.::.. . .:.
XP_005 PESEDEEEALPCTDWEN
940
>>XP_011541457 (OMIM: 604279) PREDICTED: junction-mediat (956 aa)
initn: 1253 init1: 944 opt: 1239 Z-score: 553.3 bits: 113.5 E(85289): 4.4e-24
Smith-Waterman score: 1428; 35.1% identity (62.6% similar) in 767 aa overlap (63-808:214-955)
40 50 60 70 80 90
pF1KSD AWNGAEGKFAVTCHDRTAQQRRLREGARLGPEPEPKPEAAVSPSSWAGLLSAAGLRGAHR
: : . :. . :::::.: ::..:.
XP_011 SASGTVSEEIEVLEMVKEDEAPLALSDAEQPPPATELESPAEECSWAGLFSFQDLRAVHQ
190 200 210 220 230 240
100 110 120 130 140 150
pF1KSD QLAALWPPLERCFPRLPPELDVGGGGAWGLGLGLWALLWPTRAGPGEAALQELCGQLERY
:: .. :: :.: .: : . :.:..:. : .. :: ::. :
XP_011 QLCSVNSQLEPCLPVFPEEPS-----------GMWTVLFGGAPEMTEQEIDTLCYQLQVY
250 260 270 280 290
160 170 180 190 200 210
pF1KSD LGAAADGCGGATVRDALFPAEGGAADC-ESPREFRERALRARWVEADARLRQVIQGHGKA
:: . : :: . ..:: . :: :.:... . .: :...... : ..
XP_011 LGHGLDTCGWKILSQVLFTETDDPEEYYESLSELRQKGYEEVLQRARKRIQELLDKHKNT
300 310 320 330 340 350
220 230 240 250 260 270
pF1KSD NTMVALMNVYQEEDEAYQELVTVATMFFQYLLQPFRAMREVATLCKLDILKSLDEDDLGP
..:: :...:: :::::. :. ..: ..:::::::: :::.: : . .: :...: :::
XP_011 ESMVELLDLYQMEDEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGP
360 370 380 390 400 410
280 290 300 310 320 330
pF1KSD RRVVALEKEAEEWTRRAEEAVVSIQDITVNYFKETVKALAGMQKEMEQDAKRFGQAAWAT
::. .:.:: .: :.:. ::.::::.::.::. :.:: .. .:. : :.::.:.::.
XP_011 RRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAA
420 430 440 450 460 470
340 350 360 370 380 390
pF1KSD AIPRLEKLQLMLARETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNTNVVDELEIQFYE
: :.:::: ...::::.:::::.::.... .. .:..: . .:.:: ..:.
XP_011 AAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYD
480 490 500 510 520 530
400 410 420 430 440 450
pF1KSD IQLELYEVKFEILKNEEILLTTQLDSLKRLIKEKQDEVVYYDPCENPEELKVIDCVVGLQ
.::.::::.::::: ::.:::.::.:.::::.::.::::::: :. : . . ...
XP_011 LQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASA
540 550 560 570 580 590
460 470 480 490 500 510
pF1KSD DDKNLEVKELRRQCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQAEESIRYSRQHH
. :...:... .:::..:::. ::.. ::..:. : .: ..:: . : ::
XP_011 YLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHH
600 610 620 630 640 650
520 530 540 550 560 570
pF1KSD SIQMKRD-KIKEEEQKKKEWINQERQKTLQRLRSFKDKRLAQSVRNTSGSEPVAPNLPSD
..:.. .. . . . ... . :. . : . .. .: :. . .
XP_011 TVQLRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKR
660 670 680 690 700 710
580 590 600 610 620 630
pF1KSD LSQQMCLPASHAVSVIHPSSRKTRGVPLSEAGNVKSPKCQNCHGNIPVQVFVPVGDQTHS
.: : : :.. : . ... : .: : : ..: . .:. ...
XP_011 GPSQTTEPQS-LVQLEDTSLTQLEATSLPLSG-VTS--------ELPPTISLPLLNNNLE
720 730 740 750 760
640 650 660 670 680
pF1KSD KSS---EELSLPPPPPPPPPPPPPPPPPPPPLRALSSSSQAATHQNLGF------RAPVK
: . : : :: :::::::::::::::: . ..:. . ...: : : .
XP_011 PCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPETLEKDLPRKEGNEKRIPKS
770 780 790 800 810 820
690 700 710 720 730
pF1KSD DDQPRPLVCESP---AERPR-----DSLESFSCPGSMDEVLASLRHGRAPLRKVEVPAVR
. : . .: . : . ..:. . ::::::::..: :.::: ..
XP_011 ASAPSAHLFDSSQLVSARKKLRKTAEGLQRRRVSSPMDEVLASLKRGSFHLKKVEQRTLP
830 840 850 860 870 880
740 750 760 770 780 790
pF1KSD P-PHASINEHILAAIRQGVKLKKVHPD-LGPNPSSKPTSNRRTSDLERSIKAALQRIKRV
: : . ...::: ::.:::::::. : : . . : :. : :::. ::.:::..
XP_011 PFPDEDDSNNILAQIRKGVKLKKVQKDVLRESFTLLPD----TDPLTRSIHEALRRIKEA
890 900 910 920 930
800
pF1KSD SADSEEDSDEQDPGQWDG
: .::.. . .:.
XP_011 SPESEDEEEALPCTDWEN
940 950
>>NP_689618 (OMIM: 604279) junction-mediating and -regul (988 aa)
initn: 1674 init1: 1081 opt: 1177 Z-score: 526.5 bits: 108.6 E(85289): 1.4e-22
Smith-Waterman score: 1576; 37.3% identity (64.4% similar) in 786 aa overlap (63-804:214-982)
40 50 60 70 80 90
pF1KSD AWNGAEGKFAVTCHDRTAQQRRLREGARLGPEPEPKPEAAVSPSSWAGLLSAAGLRGAHR
: : . :. . :::::.: ::..:.
NP_689 SASGTVSEEIEVLEMVKEDEAPLALSDAEQPPPATELESPAEECSWAGLFSFQDLRAVHQ
190 200 210 220 230 240
100 110 120 130 140 150
pF1KSD QLAALWPPLERCFPRLPPELDVGGGGAWGLGLGLWALLWPTRAGPGEAALQELCGQLERY
:: .. :: :.: .: : . :.:..:. : .. :: ::. :
NP_689 QLCSVNSQLEPCLPVFPEEPS-----------GMWTVLFGGAPEMTEQEIDTLCYQLQVY
250 260 270 280 290
160 170 180 190 200 210
pF1KSD LGAAADGCGGATVRDALFPAEGGAADC-ESPREFRERALRARWVEADARLRQVIQGHGKA
:: . : :: . ..:: . :: :.:... . .: :...... : ..
NP_689 LGHGLDTCGWKILSQVLFTETDDPEEYYESLSELRQKGYEEVLQRARKRIQELLDKHKNT
300 310 320 330 340 350
220 230 240 250 260 270
pF1KSD NTMVALMNVYQEEDEAYQELVTVATMFFQYLLQPFRAMREVATLCKLDILKSLDEDDLGP
..:: :...:: :::::. :. ..: ..:::::::: :::.: : . .: :...: :::
NP_689 ESMVELLDLYQMEDEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGP
360 370 380 390 400 410
280 290 300 310 320 330
pF1KSD RRVVALEKEAEEWTRRAEEAVVSIQDITVNYFKETVKALAGMQKEMEQDAKRFGQAAWAT
::. .:.:: .: :.:. ::.::::.::.::. :.:: .. .:. : :.::.:.::.
NP_689 RRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAA
420 430 440 450 460 470
340 350 360 370 380 390
pF1KSD AIPRLEKLQLMLARETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNTNVVDELEIQFYE
: :.:::: ...::::.:::::.::.... .. .:..: . .:.:: ..:.
NP_689 AAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYD
480 490 500 510 520 530
400 410 420 430 440 450
pF1KSD IQLELYEVKFEILKNEEILLTTQLDSLKRLIKEKQDEVVYYDPCENPEELKVIDCVVGLQ
.::.::::.::::: ::.:::.::.:.::::.::.::::::: :. : . . ...
NP_689 LQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASA
540 550 560 570 580 590
460 470 480 490 500 510
pF1KSD DDKNLEVKELRRQCQQLESKRGRICAKRASLRSRKDQCKENHRFRLQQAEESIRYSRQHH
. :...:... .:::..:::. ::.. ::..:. : .: ..:: . : ::
NP_689 YLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHH
600 610 620 630 640 650
520 530 540 550
pF1KSD SIQMKRDKIKEEEQKKKEWINQERQKTLQRLRSFKDK------------RLAQSVRNTSG
..:.::.:...::..:. :..::::.::.:::.::.. :::.. :. ..
NP_689 TVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAA
660 670 680 690 700 710
560 570 580 590 600
pF1KSD SEPV-----APNLPSDLSQQMCLPASHAVSVIHPSSRKTRG---VPLSEAG----NVKSP
: :: .::: :. . : . :. :. : : ... .. :
NP_689 S-PVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSL
720 730 740 750 760 770
610 620 630 640 650 660
pF1KSD KCQNCHGNIPVQVFVPVGDQTHSKSS---EELSLPPPPPPPPPPPPPPPPPPPPLRALSS
.. ...: . .:. ... : . : : :: :::::::::::::::: . ..
NP_689 PLSGVTSELPPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPVAKD
780 790 800 810 820 830
670 680 690 700 710
pF1KSD SSQAATHQNLGF------RAPVKDDQPRPLVCESP---AERPR-----DSLESFSCPGSM
:. . ...: : : . . : . .: . : . ..:. . :
NP_689 SGPETLEKDLPRKEGNEKRIPKSASAPSAHLFDSSQLVSARKKLRKTAEGLQRRRVSSPM
840 850 860 870 880 890
720 730 740 750 760
pF1KSD DEVLASLRHGRAPLRKVEVPAVRP-PHASINEHILAAIRQGVKLKKVHPD-LGPNPSSKP
:::::::..: :.::: .. : : . ...::: ::.:::::::. : : . . :
NP_689 DEVLASLKRGSFHLKKVEQRTLPPFPDEDDSNNILAQIRKGVKLKKVQKDVLRESFTLLP
900 910 920 930 940 950
770 780 790 800
pF1KSD TSNRRTSDLERSIKAALQRIKRVSADSEEDSDEQDPGQWDG
:. : :::. ::.:::..: .:: : .: :
NP_689 D----TDPLTRSIHEALRRIKEASPESE-DEEEALPCTDWEN
960 970 980
809 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 07:53:54 2016 done: Thu Nov 3 07:53:56 2016
Total Scan time: 13.910 Total Display time: 0.180
Function used was FASTA [36.3.4 Apr, 2011]