Result of FASTA (omim) for
pF1KSDA1972
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1972, 576 aa
1>>>pF1KSDA1972 576 - 576 aa - 576 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0640+/-0.000374; mu= 16.4129+/- 0.023
mean_var=120.0675+/-25.287, 0's: 0 Z-trim(116.1): 116 B-trim: 1252 in 1/52
Lambda= 0.117047
statistics sampled from 26937 (27075) to 26937 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.685), E-opt: 0.2 (0.317), width: 16
Scan time: 10.060
The best scores are: opt bits E(85289)
NP_001292092 (OMIM: 616585,616723) RING finger and ( 576) 3921 673.7 4.6e-193
XP_005256277 (OMIM: 616585,616723) PREDICTED: RING ( 576) 3921 673.7 4.6e-193
NP_588609 (OMIM: 616585,616723) RING finger and SP ( 576) 3921 673.7 4.6e-193
NP_001292093 (OMIM: 616585,616723) RING finger and ( 576) 3921 673.7 4.6e-193
XP_011521729 (OMIM: 616585,616723) PREDICTED: RING ( 607) 3140 541.8 2.4e-153
XP_011521732 (OMIM: 616585,616723) PREDICTED: RING ( 607) 3140 541.8 2.4e-153
XP_011521730 (OMIM: 616585,616723) PREDICTED: RING ( 607) 3140 541.8 2.4e-153
XP_016879333 (OMIM: 616585,616723) PREDICTED: RING ( 452) 3080 531.5 2.2e-150
NP_001292111 (OMIM: 616585,616723) RING finger and ( 117) 780 142.6 6.8e-34
XP_016862507 (OMIM: 614472) PREDICTED: E3 ubiquiti (1314) 320 65.9 9.2e-10
XP_011532297 (OMIM: 614472) PREDICTED: E3 ubiquiti (1314) 320 65.9 9.2e-10
NP_071347 (OMIM: 614472) E3 ubiquitin-protein liga (1314) 320 65.9 9.2e-10
XP_006713348 (OMIM: 614472) PREDICTED: E3 ubiquiti (1314) 320 65.9 9.2e-10
XP_006711872 (OMIM: 180902,600996,604772) PREDICTE (2735) 246 53.7 8.9e-06
XP_006711871 (OMIM: 180902,600996,604772) PREDICTE (4906) 246 54.0 1.4e-05
XP_006711873 (OMIM: 180902,600996,604772) PREDICTE (4954) 246 54.0 1.4e-05
XP_006711870 (OMIM: 180902,600996,604772) PREDICTE (4965) 246 54.0 1.4e-05
NP_001026 (OMIM: 180902,600996,604772) ryanodine r (4967) 246 54.0 1.4e-05
XP_006711869 (OMIM: 180902,600996,604772) PREDICTE (4973) 246 54.0 1.4e-05
XP_006711868 (OMIM: 180902,600996,604772) PREDICTE (4975) 246 54.0 1.4e-05
XP_006711867 (OMIM: 180902,600996,604772) PREDICTE (4977) 246 54.0 1.4e-05
XP_016857517 (OMIM: 180902,600996,604772) PREDICTE (4978) 246 54.0 1.4e-05
XP_006711866 (OMIM: 180902,600996,604772) PREDICTE (4984) 246 54.0 1.4e-05
XP_006711865 (OMIM: 180902,600996,604772) PREDICTE (4985) 246 54.0 1.4e-05
XP_011525507 (OMIM: 117000,145600,180901,255310,25 (5009) 240 53.0 2.8e-05
XP_006723382 (OMIM: 117000,145600,180901,255310,25 (5027) 240 53.0 2.8e-05
XP_006723380 (OMIM: 117000,145600,180901,255310,25 (5032) 240 53.0 2.8e-05
NP_001036188 (OMIM: 117000,145600,180901,255310,25 (5033) 240 53.0 2.8e-05
NP_000531 (OMIM: 117000,145600,180901,255310,25532 (5038) 240 53.0 2.8e-05
XP_016877966 (OMIM: 180903) PREDICTED: ryanodine r (3855) 214 48.5 0.00048
XP_016877965 (OMIM: 180903) PREDICTED: ryanodine r (4830) 214 48.6 0.00057
XP_016877964 (OMIM: 180903) PREDICTED: ryanodine r (4837) 214 48.6 0.00057
XP_016877963 (OMIM: 180903) PREDICTED: ryanodine r (4859) 214 48.6 0.00057
XP_011520182 (OMIM: 180903) PREDICTED: ryanodine r (4859) 214 48.6 0.00057
XP_016877962 (OMIM: 180903) PREDICTED: ryanodine r (4860) 214 48.6 0.00057
XP_016877961 (OMIM: 180903) PREDICTED: ryanodine r (4864) 214 48.6 0.00057
XP_016877959 (OMIM: 180903) PREDICTED: ryanodine r (4865) 214 48.6 0.00057
XP_016877960 (OMIM: 180903) PREDICTED: ryanodine r (4865) 214 48.6 0.00057
XP_016877958 (OMIM: 180903) PREDICTED: ryanodine r (4865) 214 48.6 0.00057
NP_001230925 (OMIM: 180903) ryanodine receptor 3 i (4865) 214 48.6 0.00057
XP_016877957 (OMIM: 180903) PREDICTED: ryanodine r (4866) 214 48.6 0.00057
NP_001027 (OMIM: 180903) ryanodine receptor 3 isof (4870) 214 48.6 0.00057
XP_005249090 (OMIM: 610082) PREDICTED: E3 ubiquiti ( 264) 184 42.3 0.0024
XP_005249089 (OMIM: 610082) PREDICTED: E3 ubiquiti ( 390) 184 42.5 0.0032
NP_037394 (OMIM: 610082) E3 ubiquitin-protein liga ( 445) 184 42.5 0.0035
>>NP_001292092 (OMIM: 616585,616723) RING finger and SPR (576 aa)
initn: 3921 init1: 3921 opt: 3921 Z-score: 3587.2 bits: 673.7 E(85289): 4.6e-193
Smith-Waterman score: 3921; 100.0% identity (100.0% similar) in 576 aa overlap (1-576:1-576)
10 20 30 40 50 60
pF1KSD MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDNDQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDNDQE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD PPYSMITLHEMAETDEGWLDVVQSLIRVIPLEDPLGPAVITLLLDECPLPTKDALQKLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPYSMITLHEMAETDEGWLDVVQSLIRVIPLEDPLGPAVITLLLDECPLPTKDALQKLTE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ILNLNGEVACQDSSHPAKHRNTSAVLGCLAEKLAGPASIGLLSPGILEYLLQCLKLQSHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILNLNGEVACQDSSHPAKHRNTSAVLGCLAEKLAGPASIGLLSPGILEYLLQCLKLQSHP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD TVMLFALIALEKFAQTSENKLTISESSISDRLVTLESWANDPDYLKRQVGFCAQWSLDNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVMLFALIALEKFAQTSENKLTISESSISDRLVTLESWANDPDYLKRQVGFCAQWSLDNL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD FLKEGRQLTYEKVNLSSIRAMLNSNDVSEYLKISPHGLEARCDASSFESVRCTFCVDAGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLKEGRQLTYEKVNLSSIRAMLNSNDVSEYLKISPHGLEARCDASSFESVRCTFCVDAGV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD WYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYSCAYDGCRQLIWYNARSKPHIHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYSCAYDGCRQLIWYNARSKPHIHP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD CWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSSTVSGFFAAASFMSYQQCEFNFGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSSTVSGFFAAASFMSYQQCEFNFGA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD KPFKYPPSMKFSTFNDYAFLTAEEKIILPRHRRLALLKQVSIRENCCSLCCDEVADTQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPFKYPPSMKFSTFNDYAFLTAEEKIILPRHRRLALLKQVSIRENCCSLCCDEVADTQLK
490 500 510 520 530 540
550 560 570
pF1KSD PCGHSDLCMDCALQLETCPLCRKEIVSRIRQISHIS
::::::::::::::::::::::::::::::::::::
NP_001 PCGHSDLCMDCALQLETCPLCRKEIVSRIRQISHIS
550 560 570
>>XP_005256277 (OMIM: 616585,616723) PREDICTED: RING fin (576 aa)
initn: 3921 init1: 3921 opt: 3921 Z-score: 3587.2 bits: 673.7 E(85289): 4.6e-193
Smith-Waterman score: 3921; 100.0% identity (100.0% similar) in 576 aa overlap (1-576:1-576)
10 20 30 40 50 60
pF1KSD MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDNDQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDNDQE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD PPYSMITLHEMAETDEGWLDVVQSLIRVIPLEDPLGPAVITLLLDECPLPTKDALQKLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPYSMITLHEMAETDEGWLDVVQSLIRVIPLEDPLGPAVITLLLDECPLPTKDALQKLTE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ILNLNGEVACQDSSHPAKHRNTSAVLGCLAEKLAGPASIGLLSPGILEYLLQCLKLQSHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILNLNGEVACQDSSHPAKHRNTSAVLGCLAEKLAGPASIGLLSPGILEYLLQCLKLQSHP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD TVMLFALIALEKFAQTSENKLTISESSISDRLVTLESWANDPDYLKRQVGFCAQWSLDNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TVMLFALIALEKFAQTSENKLTISESSISDRLVTLESWANDPDYLKRQVGFCAQWSLDNL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD FLKEGRQLTYEKVNLSSIRAMLNSNDVSEYLKISPHGLEARCDASSFESVRCTFCVDAGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLKEGRQLTYEKVNLSSIRAMLNSNDVSEYLKISPHGLEARCDASSFESVRCTFCVDAGV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD WYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYSCAYDGCRQLIWYNARSKPHIHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYSCAYDGCRQLIWYNARSKPHIHP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD CWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSSTVSGFFAAASFMSYQQCEFNFGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSSTVSGFFAAASFMSYQQCEFNFGA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD KPFKYPPSMKFSTFNDYAFLTAEEKIILPRHRRLALLKQVSIRENCCSLCCDEVADTQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPFKYPPSMKFSTFNDYAFLTAEEKIILPRHRRLALLKQVSIRENCCSLCCDEVADTQLK
490 500 510 520 530 540
550 560 570
pF1KSD PCGHSDLCMDCALQLETCPLCRKEIVSRIRQISHIS
::::::::::::::::::::::::::::::::::::
XP_005 PCGHSDLCMDCALQLETCPLCRKEIVSRIRQISHIS
550 560 570
>>NP_588609 (OMIM: 616585,616723) RING finger and SPRY d (576 aa)
initn: 3921 init1: 3921 opt: 3921 Z-score: 3587.2 bits: 673.7 E(85289): 4.6e-193
Smith-Waterman score: 3921; 100.0% identity (100.0% similar) in 576 aa overlap (1-576:1-576)
10 20 30 40 50 60
pF1KSD MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_588 MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDNDQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_588 QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDNDQE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD PPYSMITLHEMAETDEGWLDVVQSLIRVIPLEDPLGPAVITLLLDECPLPTKDALQKLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_588 PPYSMITLHEMAETDEGWLDVVQSLIRVIPLEDPLGPAVITLLLDECPLPTKDALQKLTE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ILNLNGEVACQDSSHPAKHRNTSAVLGCLAEKLAGPASIGLLSPGILEYLLQCLKLQSHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_588 ILNLNGEVACQDSSHPAKHRNTSAVLGCLAEKLAGPASIGLLSPGILEYLLQCLKLQSHP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD TVMLFALIALEKFAQTSENKLTISESSISDRLVTLESWANDPDYLKRQVGFCAQWSLDNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_588 TVMLFALIALEKFAQTSENKLTISESSISDRLVTLESWANDPDYLKRQVGFCAQWSLDNL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD FLKEGRQLTYEKVNLSSIRAMLNSNDVSEYLKISPHGLEARCDASSFESVRCTFCVDAGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_588 FLKEGRQLTYEKVNLSSIRAMLNSNDVSEYLKISPHGLEARCDASSFESVRCTFCVDAGV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD WYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYSCAYDGCRQLIWYNARSKPHIHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_588 WYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYSCAYDGCRQLIWYNARSKPHIHP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD CWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSSTVSGFFAAASFMSYQQCEFNFGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_588 CWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSSTVSGFFAAASFMSYQQCEFNFGA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD KPFKYPPSMKFSTFNDYAFLTAEEKIILPRHRRLALLKQVSIRENCCSLCCDEVADTQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_588 KPFKYPPSMKFSTFNDYAFLTAEEKIILPRHRRLALLKQVSIRENCCSLCCDEVADTQLK
490 500 510 520 530 540
550 560 570
pF1KSD PCGHSDLCMDCALQLETCPLCRKEIVSRIRQISHIS
::::::::::::::::::::::::::::::::::::
NP_588 PCGHSDLCMDCALQLETCPLCRKEIVSRIRQISHIS
550 560 570
>>NP_001292093 (OMIM: 616585,616723) RING finger and SPR (576 aa)
initn: 3921 init1: 3921 opt: 3921 Z-score: 3587.2 bits: 673.7 E(85289): 4.6e-193
Smith-Waterman score: 3921; 100.0% identity (100.0% similar) in 576 aa overlap (1-576:1-576)
10 20 30 40 50 60
pF1KSD MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDNDQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDNDQE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD PPYSMITLHEMAETDEGWLDVVQSLIRVIPLEDPLGPAVITLLLDECPLPTKDALQKLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPYSMITLHEMAETDEGWLDVVQSLIRVIPLEDPLGPAVITLLLDECPLPTKDALQKLTE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD ILNLNGEVACQDSSHPAKHRNTSAVLGCLAEKLAGPASIGLLSPGILEYLLQCLKLQSHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILNLNGEVACQDSSHPAKHRNTSAVLGCLAEKLAGPASIGLLSPGILEYLLQCLKLQSHP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD TVMLFALIALEKFAQTSENKLTISESSISDRLVTLESWANDPDYLKRQVGFCAQWSLDNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVMLFALIALEKFAQTSENKLTISESSISDRLVTLESWANDPDYLKRQVGFCAQWSLDNL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD FLKEGRQLTYEKVNLSSIRAMLNSNDVSEYLKISPHGLEARCDASSFESVRCTFCVDAGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLKEGRQLTYEKVNLSSIRAMLNSNDVSEYLKISPHGLEARCDASSFESVRCTFCVDAGV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD WYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYSCAYDGCRQLIWYNARSKPHIHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYSCAYDGCRQLIWYNARSKPHIHP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD CWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSSTVSGFFAAASFMSYQQCEFNFGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSSTVSGFFAAASFMSYQQCEFNFGA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD KPFKYPPSMKFSTFNDYAFLTAEEKIILPRHRRLALLKQVSIRENCCSLCCDEVADTQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPFKYPPSMKFSTFNDYAFLTAEEKIILPRHRRLALLKQVSIRENCCSLCCDEVADTQLK
490 500 510 520 530 540
550 560 570
pF1KSD PCGHSDLCMDCALQLETCPLCRKEIVSRIRQISHIS
::::::::::::::::::::::::::::::::::::
NP_001 PCGHSDLCMDCALQLETCPLCRKEIVSRIRQISHIS
550 560 570
>>XP_011521729 (OMIM: 616585,616723) PREDICTED: RING fin (607 aa)
initn: 3901 init1: 3135 opt: 3140 Z-score: 2874.1 bits: 541.8 E(85289): 2.4e-153
Smith-Waterman score: 3843; 94.7% identity (94.9% similar) in 607 aa overlap (1-576:1-607)
10 20 30 40 50 60
pF1KSD MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
10 20 30 40 50 60
70 80 90 100 110
pF1KSD QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVD----
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDKRKL
70 80 90 100 110 120
120 130 140
pF1KSD ---------------------------NDQEPPYSMITLHEMAETDEGWLDVVQSLIRVI
.::::::::::::::::::::::::::::::::
XP_011 QNEDAYIGPCFHKSSTGIVVSLPGISLSDQEPPYSMITLHEMAETDEGWLDVVQSLIRVI
130 140 150 160 170 180
150 160 170 180 190 200
pF1KSD PLEDPLGPAVITLLLDECPLPTKDALQKLTEILNLNGEVACQDSSHPAKHRNTSAVLGCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLEDPLGPAVITLLLDECPLPTKDALQKLTEILNLNGEVACQDSSHPAKHRNTSAVLGCL
190 200 210 220 230 240
210 220 230 240 250 260
pF1KSD AEKLAGPASIGLLSPGILEYLLQCLKLQSHPTVMLFALIALEKFAQTSENKLTISESSIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEKLAGPASIGLLSPGILEYLLQCLKLQSHPTVMLFALIALEKFAQTSENKLTISESSIS
250 260 270 280 290 300
270 280 290 300 310 320
pF1KSD DRLVTLESWANDPDYLKRQVGFCAQWSLDNLFLKEGRQLTYEKVNLSSIRAMLNSNDVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRLVTLESWANDPDYLKRQVGFCAQWSLDNLFLKEGRQLTYEKVNLSSIRAMLNSNDVSE
310 320 330 340 350 360
330 340 350 360 370 380
pF1KSD YLKISPHGLEARCDASSFESVRCTFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLKISPHGLEARCDASSFESVRCTFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEG
370 380 390 400 410 420
390 400 410 420 430 440
pF1KSD YGIGDDEYSCAYDGCRQLIWYNARSKPHIHPCWKEGDTVGFLLDLNEKQMIFFLNGNQLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGIGDDEYSCAYDGCRQLIWYNARSKPHIHPCWKEGDTVGFLLDLNEKQMIFFLNGNQLP
430 440 450 460 470 480
450 460 470 480 490 500
pF1KSD PEKQVFSSTVSGFFAAASFMSYQQCEFNFGAKPFKYPPSMKFSTFNDYAFLTAEEKIILP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEKQVFSSTVSGFFAAASFMSYQQCEFNFGAKPFKYPPSMKFSTFNDYAFLTAEEKIILP
490 500 510 520 530 540
510 520 530 540 550 560
pF1KSD RHRRLALLKQVSIRENCCSLCCDEVADTQLKPCGHSDLCMDCALQLETCPLCRKEIVSRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHRRLALLKQVSIRENCCSLCCDEVADTQLKPCGHSDLCMDCALQLETCPLCRKEIVSRI
550 560 570 580 590 600
570
pF1KSD RQISHIS
:::::::
XP_011 RQISHIS
>>XP_011521732 (OMIM: 616585,616723) PREDICTED: RING fin (607 aa)
initn: 3901 init1: 3135 opt: 3140 Z-score: 2874.1 bits: 541.8 E(85289): 2.4e-153
Smith-Waterman score: 3843; 94.7% identity (94.9% similar) in 607 aa overlap (1-576:1-607)
10 20 30 40 50 60
pF1KSD MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
10 20 30 40 50 60
70 80 90 100 110
pF1KSD QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVD----
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDKRKL
70 80 90 100 110 120
120 130 140
pF1KSD ---------------------------NDQEPPYSMITLHEMAETDEGWLDVVQSLIRVI
.::::::::::::::::::::::::::::::::
XP_011 QNEDAYIGPCFHKSSTGIVVSLPGISLSDQEPPYSMITLHEMAETDEGWLDVVQSLIRVI
130 140 150 160 170 180
150 160 170 180 190 200
pF1KSD PLEDPLGPAVITLLLDECPLPTKDALQKLTEILNLNGEVACQDSSHPAKHRNTSAVLGCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLEDPLGPAVITLLLDECPLPTKDALQKLTEILNLNGEVACQDSSHPAKHRNTSAVLGCL
190 200 210 220 230 240
210 220 230 240 250 260
pF1KSD AEKLAGPASIGLLSPGILEYLLQCLKLQSHPTVMLFALIALEKFAQTSENKLTISESSIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEKLAGPASIGLLSPGILEYLLQCLKLQSHPTVMLFALIALEKFAQTSENKLTISESSIS
250 260 270 280 290 300
270 280 290 300 310 320
pF1KSD DRLVTLESWANDPDYLKRQVGFCAQWSLDNLFLKEGRQLTYEKVNLSSIRAMLNSNDVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRLVTLESWANDPDYLKRQVGFCAQWSLDNLFLKEGRQLTYEKVNLSSIRAMLNSNDVSE
310 320 330 340 350 360
330 340 350 360 370 380
pF1KSD YLKISPHGLEARCDASSFESVRCTFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLKISPHGLEARCDASSFESVRCTFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEG
370 380 390 400 410 420
390 400 410 420 430 440
pF1KSD YGIGDDEYSCAYDGCRQLIWYNARSKPHIHPCWKEGDTVGFLLDLNEKQMIFFLNGNQLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGIGDDEYSCAYDGCRQLIWYNARSKPHIHPCWKEGDTVGFLLDLNEKQMIFFLNGNQLP
430 440 450 460 470 480
450 460 470 480 490 500
pF1KSD PEKQVFSSTVSGFFAAASFMSYQQCEFNFGAKPFKYPPSMKFSTFNDYAFLTAEEKIILP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEKQVFSSTVSGFFAAASFMSYQQCEFNFGAKPFKYPPSMKFSTFNDYAFLTAEEKIILP
490 500 510 520 530 540
510 520 530 540 550 560
pF1KSD RHRRLALLKQVSIRENCCSLCCDEVADTQLKPCGHSDLCMDCALQLETCPLCRKEIVSRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHRRLALLKQVSIRENCCSLCCDEVADTQLKPCGHSDLCMDCALQLETCPLCRKEIVSRI
550 560 570 580 590 600
570
pF1KSD RQISHIS
:::::::
XP_011 RQISHIS
>>XP_011521730 (OMIM: 616585,616723) PREDICTED: RING fin (607 aa)
initn: 3901 init1: 3135 opt: 3140 Z-score: 2874.1 bits: 541.8 E(85289): 2.4e-153
Smith-Waterman score: 3843; 94.7% identity (94.9% similar) in 607 aa overlap (1-576:1-607)
10 20 30 40 50 60
pF1KSD MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
10 20 30 40 50 60
70 80 90 100 110
pF1KSD QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVD----
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDKRKL
70 80 90 100 110 120
120 130 140
pF1KSD ---------------------------NDQEPPYSMITLHEMAETDEGWLDVVQSLIRVI
.::::::::::::::::::::::::::::::::
XP_011 QNEDAYIGPCFHKSSTGIVVSLPGISLSDQEPPYSMITLHEMAETDEGWLDVVQSLIRVI
130 140 150 160 170 180
150 160 170 180 190 200
pF1KSD PLEDPLGPAVITLLLDECPLPTKDALQKLTEILNLNGEVACQDSSHPAKHRNTSAVLGCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLEDPLGPAVITLLLDECPLPTKDALQKLTEILNLNGEVACQDSSHPAKHRNTSAVLGCL
190 200 210 220 230 240
210 220 230 240 250 260
pF1KSD AEKLAGPASIGLLSPGILEYLLQCLKLQSHPTVMLFALIALEKFAQTSENKLTISESSIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEKLAGPASIGLLSPGILEYLLQCLKLQSHPTVMLFALIALEKFAQTSENKLTISESSIS
250 260 270 280 290 300
270 280 290 300 310 320
pF1KSD DRLVTLESWANDPDYLKRQVGFCAQWSLDNLFLKEGRQLTYEKVNLSSIRAMLNSNDVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRLVTLESWANDPDYLKRQVGFCAQWSLDNLFLKEGRQLTYEKVNLSSIRAMLNSNDVSE
310 320 330 340 350 360
330 340 350 360 370 380
pF1KSD YLKISPHGLEARCDASSFESVRCTFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLKISPHGLEARCDASSFESVRCTFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEG
370 380 390 400 410 420
390 400 410 420 430 440
pF1KSD YGIGDDEYSCAYDGCRQLIWYNARSKPHIHPCWKEGDTVGFLLDLNEKQMIFFLNGNQLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGIGDDEYSCAYDGCRQLIWYNARSKPHIHPCWKEGDTVGFLLDLNEKQMIFFLNGNQLP
430 440 450 460 470 480
450 460 470 480 490 500
pF1KSD PEKQVFSSTVSGFFAAASFMSYQQCEFNFGAKPFKYPPSMKFSTFNDYAFLTAEEKIILP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEKQVFSSTVSGFFAAASFMSYQQCEFNFGAKPFKYPPSMKFSTFNDYAFLTAEEKIILP
490 500 510 520 530 540
510 520 530 540 550 560
pF1KSD RHRRLALLKQVSIRENCCSLCCDEVADTQLKPCGHSDLCMDCALQLETCPLCRKEIVSRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHRRLALLKQVSIRENCCSLCCDEVADTQLKPCGHSDLCMDCALQLETCPLCRKEIVSRI
550 560 570 580 590 600
570
pF1KSD RQISHIS
:::::::
XP_011 RQISHIS
>>XP_016879333 (OMIM: 616585,616723) PREDICTED: RING fin (452 aa)
initn: 3080 init1: 3080 opt: 3080 Z-score: 2821.0 bits: 531.5 E(85289): 2.2e-150
Smith-Waterman score: 3080; 100.0% identity (100.0% similar) in 452 aa overlap (125-576:1-452)
100 110 120 130 140 150
pF1KSD RKKQNVDGLVLDTLAVIRTLVDNDQEPPYSMITLHEMAETDEGWLDVVQSLIRVIPLEDP
::::::::::::::::::::::::::::::
XP_016 MITLHEMAETDEGWLDVVQSLIRVIPLEDP
10 20 30
160 170 180 190 200 210
pF1KSD LGPAVITLLLDECPLPTKDALQKLTEILNLNGEVACQDSSHPAKHRNTSAVLGCLAEKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGPAVITLLLDECPLPTKDALQKLTEILNLNGEVACQDSSHPAKHRNTSAVLGCLAEKLA
40 50 60 70 80 90
220 230 240 250 260 270
pF1KSD GPASIGLLSPGILEYLLQCLKLQSHPTVMLFALIALEKFAQTSENKLTISESSISDRLVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPASIGLLSPGILEYLLQCLKLQSHPTVMLFALIALEKFAQTSENKLTISESSISDRLVT
100 110 120 130 140 150
280 290 300 310 320 330
pF1KSD LESWANDPDYLKRQVGFCAQWSLDNLFLKEGRQLTYEKVNLSSIRAMLNSNDVSEYLKIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LESWANDPDYLKRQVGFCAQWSLDNLFLKEGRQLTYEKVNLSSIRAMLNSNDVSEYLKIS
160 170 180 190 200 210
340 350 360 370 380 390
pF1KSD PHGLEARCDASSFESVRCTFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHGLEARCDASSFESVRCTFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGD
220 230 240 250 260 270
400 410 420 430 440 450
pF1KSD DEYSCAYDGCRQLIWYNARSKPHIHPCWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEYSCAYDGCRQLIWYNARSKPHIHPCWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQV
280 290 300 310 320 330
460 470 480 490 500 510
pF1KSD FSSTVSGFFAAASFMSYQQCEFNFGAKPFKYPPSMKFSTFNDYAFLTAEEKIILPRHRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSSTVSGFFAAASFMSYQQCEFNFGAKPFKYPPSMKFSTFNDYAFLTAEEKIILPRHRRL
340 350 360 370 380 390
520 530 540 550 560 570
pF1KSD ALLKQVSIRENCCSLCCDEVADTQLKPCGHSDLCMDCALQLETCPLCRKEIVSRIRQISH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALLKQVSIRENCCSLCCDEVADTQLKPCGHSDLCMDCALQLETCPLCRKEIVSRIRQISH
400 410 420 430 440 450
pF1KSD IS
::
XP_016 IS
>>NP_001292111 (OMIM: 616585,616723) RING finger and SPR (117 aa)
initn: 780 init1: 780 opt: 780 Z-score: 729.5 bits: 142.6 E(85289): 6.8e-34
Smith-Waterman score: 780; 100.0% identity (100.0% similar) in 116 aa overlap (1-116:1-116)
10 20 30 40 50 60
pF1KSD MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIVFGWAVFLASRSLGQGLLLTLEEHIAHFLGTGGAATTMGNSCICRDDSGTDDSVDTQQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDNDQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQAENSAVPTADTRSQPRDPVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDK
70 80 90 100 110
130 140 150 160 170 180
pF1KSD PPYSMITLHEMAETDEGWLDVVQSLIRVIPLEDPLGPAVITLLLDECPLPTKDALQKLTE
>>XP_016862507 (OMIM: 614472) PREDICTED: E3 ubiquitin-pr (1314 aa)
initn: 269 init1: 133 opt: 320 Z-score: 296.3 bits: 65.9 E(85289): 9.2e-10
Smith-Waterman score: 320; 37.8% identity (62.2% similar) in 143 aa overlap (345-486:119-257)
320 330 340 350 360 370
pF1KSD LSSIRAMLNSNDVSEYLKISPHGLEARCDASSFESVRCTFCVDAGVWYYEVTVVTSGVMQ
:.: ..: : :: : : ::: . ..:.::
XP_016 LGPSTVVLDHTGGFEGLLLVDDDLLGVIGHSNFGTIRSTTCVYKGKWLYEVLISSQGLMQ
90 100 110 120 130 140
380 390 400 410 420 430
pF1KSD IGWATRDSKFLNHEGYGIGDDEYSCAYDGCRQLIWYNARSKPHIHPCWKEGDTVGFLLDL
::: : . .: ..: :.:: . : :::: : : :. . . : :: :. :.::
XP_016 IGWCTISCRFNQEE--GVGDTHNSYAYDGNRVRKW-NVTTTNY-GKAWAAGDIVSCLIDL
150 160 170 180 190 200
440 450 460 470 480 490
pF1KSD NEKQMIFFLNGNQLPPEKQVFSSTVS-GFFAAASFMSYQQCEFNFGAKPFKYPPSMKFST
.. . : ::: .: . .: .. ..: : :. .. ::::..:..::
XP_016 DDGTLSFCLNGVSLGTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGYRPL
210 220 230 240 250 260
500 510 520 530 540 550
pF1KSD FNDYAFLTAEEKIILPRHRRLALLKQVSIRENCCSLCCDEVADTQLKPCGHSDLCMDCAL
XP_016 QDPPSADLVRAQRLLGCFRAVLSVELDPVEGRLLDKESSKWRLRGQPTVLLTLAHIFHHF
270 280 290 300 310 320
576 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 07:54:32 2016 done: Thu Nov 3 07:54:33 2016
Total Scan time: 10.060 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]