Result of FASTA (omim) for
pF1KSDB0017
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDB0017, 1740 aa
1>>>pF1KSDB0017 1740 - 1740 aa - 1740 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.8578+/-0.000371; mu= 13.6749+/- 0.024
mean_var=150.5098+/-30.677, 0's: 0 Z-trim(117.5): 106 B-trim: 16 in 3/57
Lambda= 0.104542
statistics sampled from 29419 (29525) to 29419 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.346), width: 16
Scan time: 22.530
The best scores are: opt bits E(85289)
NP_001070651 (OMIM: 191092,606690,613254) tuberin (1740) 11464 1742.0 0
NP_001305761 (OMIM: 191092,606690,613254) tuberin (1751) 11464 1742.0 0
XP_005255588 (OMIM: 191092,606690,613254) PREDICTE (1741) 11452 1740.2 0
NP_001305758 (OMIM: 191092,606690,613254) tuberin (1692) 11143 1693.6 0
NP_001305756 (OMIM: 191092,606690,613254) tuberin (1704) 10733 1631.8 0
XP_016879106 (OMIM: 191092,606690,613254) PREDICTE (1795) 10733 1631.8 0
XP_011520942 (OMIM: 191092,606690,613254) PREDICTE (1781) 8042 1225.9 0
XP_016879105 (OMIM: 191092,606690,613254) PREDICTE (1763) 8033 1224.5 0
XP_011520941 (OMIM: 191092,606690,613254) PREDICTE (1782) 8025 1223.3 0
XP_005255586 (OMIM: 191092,606690,613254) PREDICTE (1764) 8021 1222.7 0
NP_001305760 (OMIM: 191092,606690,613254) tuberin (1563) 6740 1029.5 0
NP_001107854 (OMIM: 191092,606690,613254) tuberin (1784) 6223 951.6 0
XP_016879104 (OMIM: 191092,606690,613254) PREDICTE (1806) 6223 951.6 0
NP_000539 (OMIM: 191092,606690,613254) tuberin iso (1807) 6223 951.6 0
XP_011520939 (OMIM: 191092,606690,613254) PREDICTE (1824) 6223 951.6 0
XP_011520938 (OMIM: 191092,606690,613254) PREDICTE (1825) 6223 951.6 0
XP_011520940 (OMIM: 191092,606690,613254) PREDICTE (1879) 5504 843.1 0
XP_016879107 (OMIM: 191092,606690,613254) PREDICTE (1377) 3436 531.2 2.6e-149
NP_919277 (OMIM: 608884) ral GTPase-activating pro (2083) 350 65.8 4.7e-09
XP_005267549 (OMIM: 608884) PREDICTED: ral GTPase- (2130) 350 65.8 4.8e-09
XP_006720162 (OMIM: 608884) PREDICTED: ral GTPase- (2589) 350 65.9 5.7e-09
XP_005267555 (OMIM: 608884) PREDICTED: ral GTPase- (1325) 343 64.6 6.8e-09
XP_016876636 (OMIM: 608884) PREDICTED: ral GTPase- (1327) 343 64.6 6.8e-09
XP_016876635 (OMIM: 608884) PREDICTED: ral GTPase- (1834) 343 64.7 8.9e-09
NP_055805 (OMIM: 608884) ral GTPase-activating pro (2036) 343 64.8 9.7e-09
NP_001333172 (OMIM: 608884) ral GTPase-activating (2036) 343 64.8 9.7e-09
NP_001269972 (OMIM: 608884) ral GTPase-activating (2049) 343 64.8 9.7e-09
NP_001269973 (OMIM: 608884) ral GTPase-activating (2083) 343 64.8 9.9e-09
NP_001333174 (OMIM: 608884) ral GTPase-activating (2083) 343 64.8 9.9e-09
NP_001333175 (OMIM: 608884) ral GTPase-activating (2084) 343 64.8 9.9e-09
NP_001333176 (OMIM: 608884) ral GTPase-activating (2131) 343 64.8 1e-08
NP_001317004 (OMIM: 608884) ral GTPase-activating (2495) 343 64.8 1.1e-08
NP_001333177 (OMIM: 608884) ral GTPase-activating (2495) 343 64.8 1.1e-08
XP_006720164 (OMIM: 608884) PREDICTED: ral GTPase- (2542) 343 64.8 1.2e-08
NP_001333178 (OMIM: 608884) ral GTPase-activating (2542) 343 64.8 1.2e-08
XP_011534917 (OMIM: 608884) PREDICTED: ral GTPase- (2542) 343 64.8 1.2e-08
XP_006720163 (OMIM: 608884) PREDICTED: ral GTPase- (2543) 343 64.8 1.2e-08
XP_006720161 (OMIM: 608884) PREDICTED: ral GTPase- (2590) 343 64.8 1.2e-08
XP_016857466 (OMIM: 600278) PREDICTED: rap1 GTPase ( 617) 249 50.3 6.7e-05
XP_016857480 (OMIM: 600278) PREDICTED: rap1 GTPase ( 625) 249 50.3 6.8e-05
XP_016857465 (OMIM: 600278) PREDICTED: rap1 GTPase ( 625) 249 50.3 6.8e-05
XP_016857463 (OMIM: 600278) PREDICTED: rap1 GTPase ( 651) 249 50.3 7e-05
XP_016857479 (OMIM: 600278) PREDICTED: rap1 GTPase ( 655) 249 50.3 7.1e-05
XP_016857461 (OMIM: 600278) PREDICTED: rap1 GTPase ( 655) 249 50.3 7.1e-05
XP_016857464 (OMIM: 600278) PREDICTED: rap1 GTPase ( 655) 249 50.3 7.1e-05
XP_016857478 (OMIM: 600278) PREDICTED: rap1 GTPase ( 655) 249 50.3 7.1e-05
XP_016857476 (OMIM: 600278) PREDICTED: rap1 GTPase ( 663) 249 50.3 7.1e-05
XP_016857462 (OMIM: 600278) PREDICTED: rap1 GTPase ( 663) 249 50.3 7.1e-05
XP_016857475 (OMIM: 600278) PREDICTED: rap1 GTPase ( 663) 249 50.3 7.1e-05
NP_002876 (OMIM: 600278) rap1 GTPase-activating pr ( 663) 249 50.3 7.1e-05
>>NP_001070651 (OMIM: 191092,606690,613254) tuberin isof (1740 aa)
initn: 11464 init1: 11464 opt: 11464 Z-score: 9343.8 bits: 1742.0 E(85289): 0
Smith-Waterman score: 11464; 100.0% identity (100.0% similar) in 1740 aa overlap (1-1740:1-1740)
10 20 30 40 50 60
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD ENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD KLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD RDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLA
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEH
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD RDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMD
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KSD RRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSS
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KSD SPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPS
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KSD SSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHS
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KSD PFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHG
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KSD SYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPT
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KSD KDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQC
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KSD RKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHI
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KSD KRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
1690 1700 1710 1720 1730 1740
>>NP_001305761 (OMIM: 191092,606690,613254) tuberin isof (1751 aa)
initn: 11464 init1: 11464 opt: 11464 Z-score: 9343.7 bits: 1742.0 E(85289): 0
Smith-Waterman score: 11464; 100.0% identity (100.0% similar) in 1740 aa overlap (1-1740:12-1751)
10 20 30 40
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELS
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGFSGASWSTMAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELS
10 20 30 40 50 60
50 60 70 80 90 100
pF1KSD MECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIV
70 80 90 100 110 120
110 120 130 140 150 160
pF1KSD QGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMD
130 140 150 160 170 180
170 180 190 200 210 220
pF1KSD VGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYN
190 200 210 220 230 240
230 240 250 260 270 280
pF1KSD CLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDA
250 260 270 280 290 300
290 300 310 320 330 340
pF1KSD PLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKY
310 320 330 340 350 360
350 360 370 380 390 400
pF1KSD RKELQVVAWDILLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKELQVVAWDILLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFE
370 380 390 400 410 420
410 420 430 440 450 460
pF1KSD LVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVL
430 440 450 460 470 480
470 480 490 500 510 520
pF1KSD SFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLD
490 500 510 520 530 540
530 540 550 560 570 580
pF1KSD IIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEM
550 560 570 580 590 600
590 600 610 620 630 640
pF1KSD LVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYM
610 620 630 640 650 660
650 660 670 680 690 700
pF1KSD EPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLV
670 680 690 700 710 720
710 720 730 740 750 760
pF1KSD LGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPV
730 740 750 760 770 780
770 780 790 800 810 820
pF1KSD LTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVK
790 800 810 820 830 840
830 840 850 860 870 880
pF1KSD LTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLA
850 860 870 880 890 900
890 900 910 920 930 940
pF1KSD HHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQT
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KSD SLTSASLGSADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLTSASLGSADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLA
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KSD GGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLE
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KSD SQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGT
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KSD RVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSN
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KSD ALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPG
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KSD LEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSF
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KSD QPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGED
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KSD SRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGIN
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KSD PSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSN
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KSD SELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQ
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KSD AVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPL
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KSD DYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIY
1630 1640 1650 1660 1670 1680
1670 1680 1690 1700 1710 1720
pF1KSD PSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRL
1690 1700 1710 1720 1730 1740
1730 1740
pF1KSD ISSVEDFTEFV
:::::::::::
NP_001 ISSVEDFTEFV
1750
>>XP_005255588 (OMIM: 191092,606690,613254) PREDICTED: t (1741 aa)
initn: 11450 init1: 6221 opt: 11452 Z-score: 9334.0 bits: 1740.2 E(85289): 0
Smith-Waterman score: 11452; 99.9% identity (99.9% similar) in 1741 aa overlap (1-1740:1-1741)
10 20 30 40 50 60
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
850 860 870 880 890 900
910 920 930 940 950
pF1KSD RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK-RIQTSLTSASLGSA
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
XP_005 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSRIQTSLTSASLGSA
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KSD DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KSD NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KSD ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KSD AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KSD HRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGM
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KSD DRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSS
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KSD SSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLP
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KSD SSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYH
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KSD SPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEH
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KSD GSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMP
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KSD TKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQ
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KSD CRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRH
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KSD IKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEF
1690 1700 1710 1720 1730 1740
1740
pF1KSD V
:
XP_005 V
>>NP_001305758 (OMIM: 191092,606690,613254) tuberin isof (1692 aa)
initn: 11141 init1: 5912 opt: 11143 Z-score: 9082.3 bits: 1693.6 E(85289): 0
Smith-Waterman score: 11143; 99.9% identity (99.9% similar) in 1692 aa overlap (50-1740:1-1692)
20 30 40 50 60 70
pF1KSD GLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVE
::::::::::::::::::::::::::::::
NP_001 MECGLNNRIRMIGQICEVAKTKKFEEHAVE
10 20 30
80 90 100 110 120 130
pF1KSD ALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHER
40 50 60 70 80 90
140 150 160 170 180 190
pF1KSD LEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMV
100 110 120 130 140 150
200 210 220 230 240 250
pF1KSD QMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKL
160 170 180 190 200 210
260 270 280 290 300 310
pF1KSD MRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSV
220 230 240 250 260 270
320 330 340 350 360 370
pF1KSD LPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDSPE
280 290 300 310 320 330
380 390 400 410 420 430
pF1KSD LRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKD
340 350 360 370 380 390
440 450 460 470 480 490
pF1KSD GWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPED
400 410 420 430 440 450
500 510 520 530 540 550
pF1KSD KDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPPELEERDVAAYSASLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPPELEERDVAAYSASLED
460 470 480 490 500 510
560 570 580 590 600 610
pF1KSD VKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLL
520 530 540 550 560 570
620 630 640 650 660 670
pF1KSD LLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAV
580 590 600 610 620 630
680 690 700 710 720 730
pF1KSD RLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCS
640 650 660 670 680 690
740 750 760 770 780 790
pF1KSD MLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHR
700 710 720 730 740 750
800 810 820 830 840 850
pF1KSD CASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRN
760 770 780 790 800 810
860 870 880 890 900 910
pF1KSD FAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSN
820 830 840 850 860 870
920 930 940 950 960 970
pF1KSD VLLSFDDTPEKDSFRARSTSLNERPK-RIQTSLTSASLGSADENSVAQADDSLKNLHLEL
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_001 VLLSFDDTPEKDSFRARSTSLNERPKSRIQTSLTSASLGSADENSVAQADDSLKNLHLEL
880 890 900 910 920 930
980 990 1000 1010 1020 1030
pF1KSD TETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLG
940 950 960 970 980 990
1040 1050 1060 1070 1080 1090
pF1KSD LDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGAL
1000 1010 1020 1030 1040 1050
1100 1110 1120 1130 1140 1150
pF1KSD DVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRP
1060 1070 1080 1090 1100 1110
1160 1170 1180 1190 1200 1210
pF1KSD TGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAK
1120 1130 1140 1150 1160 1170
1220 1230 1240 1250 1260 1270
pF1KSD PPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEK
1180 1190 1200 1210 1220 1230
1280 1290 1300 1310 1320 1330
pF1KSD SLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKA
1240 1250 1260 1270 1280 1290
1340 1350 1360 1370 1380 1390
pF1KSD DVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISD
1300 1310 1320 1330 1340 1350
1400 1410 1420 1430 1440 1450
pF1KSD SAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQ
1360 1370 1380 1390 1400 1410
1460 1470 1480 1490 1500 1510
pF1KSD SFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELK
1420 1430 1440 1450 1460 1470
1520 1530 1540 1550 1560 1570
pF1KSD DCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDF
1480 1490 1500 1510 1520 1530
1580 1590 1600 1610 1620 1630
pF1KSD VSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSD
1540 1550 1560 1570 1580 1590
1640 1650 1660 1670 1680 1690
pF1KSD RNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSL
1600 1610 1620 1630 1640 1650
1700 1710 1720 1730 1740
pF1KSD PLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
::::::::::::::::::::::::::::::::::::::::::
NP_001 PLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
1660 1670 1680 1690
>>NP_001305756 (OMIM: 191092,606690,613254) tuberin isof (1704 aa)
initn: 10731 init1: 5502 opt: 10733 Z-score: 8748.1 bits: 1631.8 E(85289): 0
Smith-Waterman score: 11132; 97.8% identity (97.8% similar) in 1741 aa overlap (1-1740:1-1704)
10 20 30 40 50 60
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
::::::::::::::: ::::::::
NP_001 IGQICEVAKTKKFEE-------------------------------------GERLGVLR
70 80
130 140 150 160 170 180
pF1KSD ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
90 100 110 120 130 140
190 200 210 220 230 240
pF1KSD VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
150 160 170 180 190 200
250 260 270 280 290 300
pF1KSD VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
210 220 230 240 250 260
310 320 330 340 350 360
pF1KSD MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
270 280 290 300 310 320
370 380 390 400 410 420
pF1KSD LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
330 340 350 360 370 380
430 440 450 460 470 480
pF1KSD SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
390 400 410 420 430 440
490 500 510 520 530 540
pF1KSD EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
450 460 470 480 490 500
550 560 570 580 590 600
pF1KSD PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
510 520 530 540 550 560
610 620 630 640 650 660
pF1KSD SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
570 580 590 600 610 620
670 680 690 700 710 720
pF1KSD GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
630 640 650 660 670 680
730 740 750 760 770 780
pF1KSD VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
690 700 710 720 730 740
790 800 810 820 830 840
pF1KSD DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
750 760 770 780 790 800
850 860 870 880 890 900
pF1KSD VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
810 820 830 840 850 860
910 920 930 940 950
pF1KSD RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK-RIQTSLTSASLGSA
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
NP_001 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSRIQTSLTSASLGSA
870 880 890 900 910 920
960 970 980 990 1000 1010
pF1KSD DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
930 940 950 960 970 980
1020 1030 1040 1050 1060 1070
pF1KSD NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
990 1000 1010 1020 1030 1040
1080 1090 1100 1110 1120 1130
pF1KSD ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
1050 1060 1070 1080 1090 1100
1140 1150 1160 1170 1180 1190
pF1KSD AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
1110 1120 1130 1140 1150 1160
1200 1210 1220 1230 1240 1250
pF1KSD HRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRDTALYKSLSVPAASTAKPPPLPRSNTDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGM
1170 1180 1190 1200 1210 1220
1260 1270 1280 1290 1300 1310
pF1KSD DRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSS
1230 1240 1250 1260 1270 1280
1320 1330 1340 1350 1360 1370
pF1KSD SSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLP
1290 1300 1310 1320 1330 1340
1380 1390 1400 1410 1420 1430
pF1KSD SSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYH
1350 1360 1370 1380 1390 1400
1440 1450 1460 1470 1480 1490
pF1KSD SPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEH
1410 1420 1430 1440 1450 1460
1500 1510 1520 1530 1540 1550
pF1KSD GSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMP
1470 1480 1490 1500 1510 1520
1560 1570 1580 1590 1600 1610
pF1KSD TKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQ
1530 1540 1550 1560 1570 1580
1620 1630 1640 1650 1660 1670
pF1KSD CRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRH
1590 1600 1610 1620 1630 1640
1680 1690 1700 1710 1720 1730
pF1KSD IKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEF
1650 1660 1670 1680 1690 1700
1740
pF1KSD V
:
NP_001 V
>>XP_016879106 (OMIM: 191092,606690,613254) PREDICTED: t (1795 aa)
initn: 10731 init1: 5502 opt: 10733 Z-score: 8747.7 bits: 1631.8 E(85289): 0
Smith-Waterman score: 11132; 97.8% identity (97.8% similar) in 1741 aa overlap (1-1740:92-1795)
10 20 30
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRS
::::::::::::::::::::::::::::::
XP_016 ARGVRLSPRRGGPERGGAAREGFSGASWSTMAKPTSKDSGLKEKFKILLGLGTPRPNPRS
70 80 90 100 110 120
40 50 60 70 80 90
pF1KSD AEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEEHAVEALWKAVADLLQ
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEVAKTKKFEE---------------
130 140 150 160
100 110 120 130 140 150
pF1KSD PERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNG
::::::::::::::::::::::::::::::::::::::
XP_016 ----------------------GERLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNG
170 180 190 200
160 170 180 190 200 210
pF1KSD RHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIARMVQMICLLCVRTA
210 220 230 240 250 260
220 230 240 250 260 270
pF1KSD SSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLMRNLLGTHLGH
270 280 290 300 310 320
280 290 300 310 320 330
pF1KSD SAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAMACP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQAMACP
330 340 350 360 370 380
340 350 360 370 380 390
pF1KSD NEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDSPELRTIVHDLLTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDSPELRTIVHDLLTT
390 400 410 420 430 440
400 410 420 430 440 450
pF1KSD VEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALME
450 460 470 480 490 500
460 470 480 490 500 510
pF1KSD RFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQ
510 520 530 540 550 560
520 530 540 550 560 570
pF1KSD LLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGLLVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGLLVI
570 580 590 600 610 620
580 590 600 610 620 630
pF1KSD LQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLG
630 640 650 660 670 680
640 650 660 670 680 690
pF1KSD LPNKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPNKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLF
690 700 710 720 730 740
700 710 720 730 740 750
pF1KSD RVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERL
750 760 770 780 790 800
760 770 780 790 800 810
pF1KSD RGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGAPEGFSRTDLHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSI
810 820 830 840 850 860
820 830 840 850 860 870
pF1KSD CSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSVEMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFA
870 880 890 900 910 920
880 890 900 910 920 930
pF1KSD ISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEK
930 940 950 960 970 980
940 950 960 970 980
pF1KSD DSFRARSTSLNERPK-RIQTSLTSASLGSADENSVAQADDSLKNLHLELTETCLDMMARY
::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSFRARSTSLNERPKSRIQTSLTSASLGSADENSVAQADDSLKNLHLELTETCLDMMARY
990 1000 1010 1020 1030 1040
990 1000 1010 1020 1030 1040
pF1KSD VFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPE
1050 1060 1070 1080 1090 1100
1050 1060 1070 1080 1090 1100
pF1KSD SSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSSPGVHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALDVPASQFLGSA
1110 1120 1130 1140 1150 1160
1110 1120 1130 1140 1150 1160
pF1KSD TSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSPGPRTAPAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLE
1170 1180 1190 1200 1210 1220
1170 1180 1190 1200 1210 1220
pF1KSD NPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLPRSNTDS
1230 1240 1250 1260 1270 1280
1230 1240 1250 1260 1270 1280
pF1KSD AVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRG
1290 1300 1310 1320 1330 1340
1290 1300 1310 1320 1330 1340
pF1KSD IPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKA
1350 1360 1370 1380 1390 1400
1350 1360 1370 1380 1390 1400
pF1KSD RSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVE
1410 1420 1430 1440 1450 1460
1410 1420 1430 1440 1450 1460
pF1KSD RDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQ
1470 1480 1490 1500 1510 1520
1470 1480 1490 1500 1510 1520
pF1KSD IPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGG
1530 1540 1550 1560 1570 1580
1530 1540 1550 1560 1570 1580
pF1KSD LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGED
1590 1600 1610 1620 1630 1640
1590 1600 1610 1620 1630 1640
pF1KSD FKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMA
1650 1660 1670 1680 1690 1700
1650 1660 1670 1680 1690 1700
pF1KSD LHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKA
1710 1720 1730 1740 1750 1760
1710 1720 1730 1740
pF1KSD PAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
:::::::::::::::::::::::::::::::
XP_016 PAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
1770 1780 1790
>>XP_011520942 (OMIM: 191092,606690,613254) PREDICTED: t (1781 aa)
initn: 11450 init1: 8033 opt: 8042 Z-score: 6554.3 bits: 1225.9 E(85289): 0
Smith-Waterman score: 11316; 97.7% identity (97.7% similar) in 1772 aa overlap (1-1731:1-1772)
10 20 30 40 50 60
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD ENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD KLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD RDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLA
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEH
1150 1160 1170 1180 1190 1200
1210 1220
pF1KSD RDTALYKSLSVPAASTAKPPPLPRSNT---------------------------------
:::::::::::::::::::::::::::
XP_011 RDTALYKSLSVPAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWAGIASQREAVG
1210 1220 1230 1240 1250 1260
1230 1240 1250 1260 1270
pF1KSD --------DSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKS
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CRAPLCLIDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKS
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KSD LHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKAD
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KSD VGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDS
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KSD APSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQS
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KSD FERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKD
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560 1570
pF1KSD CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFV
1570 1580 1590 1600 1610 1620
1580 1590 1600 1610 1620 1630
pF1KSD SIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDR
1630 1640 1650 1660 1670 1680
1640 1650 1660 1670 1680 1690
pF1KSD NLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLP
1690 1700 1710 1720 1730 1740
1700 1710 1720 1730 1740
pF1KSD LVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
::::::::::::::::::::::::::::::::
XP_011 LVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
1750 1760 1770 1780
>>XP_016879105 (OMIM: 191092,606690,613254) PREDICTED: t (1763 aa)
initn: 8033 init1: 8033 opt: 8033 Z-score: 6547.0 bits: 1224.5 E(85289): 0
Smith-Waterman score: 11408; 98.7% identity (98.7% similar) in 1763 aa overlap (1-1740:1-1763)
10 20 30 40 50 60
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKRIQTSLTSASLGSAD
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD ENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGN
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD KLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRGA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD RDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNLA
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEH
1150 1160 1170 1180 1190 1200
1210 1220 1230
pF1KSD RDTALYKSLSVPAASTAKPPPLPRSNT-----------------------DSAVVMEEGS
::::::::::::::::::::::::::: ::::::::::
XP_016 RDTALYKSLSVPAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEGS
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KSD PGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVVS
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KSD SEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTLD
1330 1340 1350 1360 1370 1380
1360 1370 1380 1390 1400 1410
pF1KSD GESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRA
1390 1400 1410 1420 1430 1440
1420 1430 1440 1450 1460 1470
pF1KSD TASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTHK
1450 1460 1470 1480 1490 1500
1480 1490 1500 1510 1520 1530
pF1KSD IAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDG
1510 1520 1530 1540 1550 1560
1540 1550 1560 1570 1580 1590
pF1KSD QFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIKG
1570 1580 1590 1600 1610 1620
1600 1610 1620 1630 1640 1650
pF1KSD QFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQ
1630 1640 1650 1660 1670 1680
1660 1670 1680 1690 1700 1710
pF1KSD VHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAEP
1690 1700 1710 1720 1730 1740
1720 1730 1740
pF1KSD TPGYEVGQRKRLISSVEDFTEFV
:::::::::::::::::::::::
XP_016 TPGYEVGQRKRLISSVEDFTEFV
1750 1760
>>XP_011520941 (OMIM: 191092,606690,613254) PREDICTED: t (1782 aa)
initn: 11436 init1: 6221 opt: 8025 Z-score: 6540.5 bits: 1223.3 E(85289): 0
Smith-Waterman score: 11299; 97.6% identity (97.6% similar) in 1772 aa overlap (1-1730:1-1772)
10 20 30 40 50 60
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
850 860 870 880 890 900
910 920 930 940 950
pF1KSD RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK-RIQTSLTSASLGSA
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
XP_011 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSRIQTSLTSASLGSA
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KSD DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KSD NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KSD ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KSD AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
1150 1160 1170 1180 1190 1200
1200 1210 1220
pF1KSD HRDTALYKSLSVPAASTAKPPPLPRSNT--------------------------------
::::::::::::::::::::::::::::
XP_011 HRDTALYKSLSVPAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWAGIASQREAV
1210 1220 1230 1240 1250 1260
1230 1240 1250 1260 1270
pF1KSD ---------DSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEK
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCRAPLCLIDSAVVMEEGSPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEK
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KSD SLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKA
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KSD DVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVGRLSPEVKARSQSGTLDGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISD
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KSD SAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQ
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KSD SFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELK
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560 1570
pF1KSD DCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDF
1570 1580 1590 1600 1610 1620
1580 1590 1600 1610 1620 1630
pF1KSD VSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSD
1630 1640 1650 1660 1670 1680
1640 1650 1660 1670 1680 1690
pF1KSD RNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSL
1690 1700 1710 1720 1730 1740
1700 1710 1720 1730 1740
pF1KSD PLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
::::::::::::::::::::::::::::::::
XP_011 PLVHPPSHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEFV
1750 1760 1770 1780
>>XP_005255586 (OMIM: 191092,606690,613254) PREDICTED: t (1764 aa)
initn: 9639 init1: 6221 opt: 8021 Z-score: 6537.3 bits: 1222.7 E(85289): 0
Smith-Waterman score: 11396; 98.6% identity (98.6% similar) in 1764 aa overlap (1-1740:1-1764)
10 20 30 40 50 60
pF1KSD MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VNLVKFNSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MALWGAHRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLNIIERLLQQLQTLDSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKH
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYMEPERGSEKKTS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLPESLRYK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHNYL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC
850 860 870 880 890 900
910 920 930 940 950
pF1KSD RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPK-RIQTSLTSASLGSA
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
XP_005 RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSRIQTSLTSASLGSA
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KSD DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVG
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KSD NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVRQTKEAPAKLESQAGQQVSRG
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KSD ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARDRVRSMSGGHGLRVGALDVPASQFLGSATSPGPRTAPAAKPEKASAGTRVPVQEKTNL
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KSD AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKE
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230
pF1KSD HRDTALYKSLSVPAASTAKPPPLPRSNT-----------------------DSAVVMEEG
:::::::::::::::::::::::::::: :::::::::
XP_005 HRDTALYKSLSVPAASTAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSWADSAVVMEEG
1210 1220 1230 1240 1250 1260
1240 1250 1260 1270 1280 1290
pF1KSD SPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPGEVPVLVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQEEKSLHAEELVGRGIPIERVV
1270 1280 1290 1300 1310 1320
1300 1310 1320 1330 1340 1350
pF1KSD SSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSEGGRPSVDLSFQPSQPLSKSSSSPELQTLQDILGDPGDKADVGRLSPEVKARSQSGTL
1330 1340 1350 1360 1370 1380
1360 1370 1380 1390 1400 1410
pF1KSD DGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DGESAAWSASGEDSRGQPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSR
1390 1400 1410 1420 1430 1440
1420 1430 1440 1450 1460 1470
pF1KSD ATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATASNAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPSYDTH
1450 1460 1470 1480 1490 1500
1480 1490 1500 1510 1520 1530
pF1KSD KIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGED
1510 1520 1530 1540 1550 1560
1540 1550 1560 1570 1580 1590
pF1KSD GQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIVYNDSGEDFKLGTIK
1570 1580 1590 1600 1610 1620
1600 1610 1620 1630 1640 1650
pF1KSD GQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMAS
1630 1640 1650 1660 1670 1680
1660 1670 1680 1690 1700 1710
pF1KSD QVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPPSHSKAPAQTPAE
1690 1700 1710 1720 1730 1740
1720 1730 1740
pF1KSD PTPGYEVGQRKRLISSVEDFTEFV
::::::::::::::::::::::::
XP_005 PTPGYEVGQRKRLISSVEDFTEFV
1750 1760
1740 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 08:06:14 2016 done: Thu Nov 3 08:06:17 2016
Total Scan time: 22.530 Total Display time: 1.180
Function used was FASTA [36.3.4 Apr, 2011]