FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDB0040, 620 aa 1>>>pF1KSDB0040 620 - 620 aa - 620 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.5776+/-0.000604; mu= 1.6073+/- 0.036 mean_var=274.5967+/-58.582, 0's: 0 Z-trim(112.1): 427 B-trim: 355 in 2/55 Lambda= 0.077397 statistics sampled from 20382 (20938) to 20382 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.598), E-opt: 0.2 (0.245), width: 16 Scan time: 8.140 The best scores are: opt bits E(85289) NP_116197 (OMIM: 609791) leucine-rich repeat and i ( 620) 4149 478.4 3.3e-134 NP_001288123 (OMIM: 609791) leucine-rich repeat an ( 614) 4112 474.2 5.7e-133 XP_016878171 (OMIM: 609791) PREDICTED: leucine-ric ( 614) 4112 474.2 5.7e-133 NP_001288128 (OMIM: 609791) leucine-rich repeat an ( 614) 4112 474.2 5.7e-133 NP_001288124 (OMIM: 609791) leucine-rich repeat an ( 614) 4112 474.2 5.7e-133 XP_011520420 (OMIM: 609791) PREDICTED: leucine-ric ( 614) 4112 474.2 5.7e-133 NP_001288129 (OMIM: 609791) leucine-rich repeat an ( 614) 4112 474.2 5.7e-133 NP_001288126 (OMIM: 609791) leucine-rich repeat an ( 614) 4112 474.2 5.7e-133 NP_001288115 (OMIM: 609791) leucine-rich repeat an ( 614) 4112 474.2 5.7e-133 NP_001288120 (OMIM: 609791) leucine-rich repeat an ( 614) 4112 474.2 5.7e-133 NP_001288127 (OMIM: 609791) leucine-rich repeat an ( 614) 4112 474.2 5.7e-133 NP_001288116 (OMIM: 609791) leucine-rich repeat an ( 614) 4112 474.2 5.7e-133 NP_001288121 (OMIM: 609791) leucine-rich repeat an ( 614) 4112 474.2 5.7e-133 NP_001288118 (OMIM: 609791) leucine-rich repeat an ( 614) 4112 474.2 5.7e-133 XP_011516021 (OMIM: 609793) PREDICTED: leucine-ric ( 606) 2519 296.3 2e-79 NP_001245211 (OMIM: 609793) leucine-rich repeat an ( 606) 2519 296.3 2e-79 XP_016869792 (OMIM: 609793) PREDICTED: leucine-ric ( 606) 2519 296.3 2e-79 XP_016869796 (OMIM: 609793) PREDICTED: leucine-ric ( 606) 2519 296.3 2e-79 XP_011516026 (OMIM: 609793) PREDICTED: leucine-ric ( 606) 2519 296.3 2e-79 NP_689783 (OMIM: 609793) leucine-rich repeat and i ( 606) 2519 296.3 2e-79 XP_011516030 (OMIM: 609793) PREDICTED: leucine-ric ( 606) 2519 296.3 2e-79 XP_016869795 (OMIM: 609793) PREDICTED: leucine-ric ( 606) 2519 296.3 2e-79 XP_016869794 (OMIM: 609793) PREDICTED: leucine-ric ( 606) 2519 296.3 2e-79 XP_016869793 (OMIM: 609793) PREDICTED: leucine-ric ( 606) 2519 296.3 2e-79 NP_001094861 (OMIM: 609792) leucine-rich repeat an ( 592) 1857 222.4 3.5e-57 NP_001004432 (OMIM: 609794) leucine-rich repeat an ( 593) 1491 181.5 7e-45 NP_060960 (OMIM: 606666,615311) leucine-rich repea ( 951) 533 74.8 1.5e-12 NP_001245348 (OMIM: 608817) leucine-rich repeat-co ( 640) 529 74.2 1.6e-12 XP_016873568 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 XP_011518542 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 XP_011518544 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 XP_016873567 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 XP_016873563 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 XP_011518540 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 XP_016873562 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 NP_065980 (OMIM: 608817) leucine-rich repeat-conta ( 640) 529 74.2 1.6e-12 XP_011518546 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 XP_016873566 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 XP_011518541 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 XP_011518545 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 XP_016873565 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 XP_016873559 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 XP_016873564 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 XP_016873561 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 XP_011518543 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 XP_016873560 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 529 74.2 1.6e-12 NP_001278917 (OMIM: 603104) carboxypeptidase N sub ( 545) 522 73.3 2.5e-12 NP_001073982 (OMIM: 603104) carboxypeptidase N sub ( 545) 522 73.3 2.5e-12 XP_005269337 (OMIM: 603104) PREDICTED: carboxypept ( 545) 522 73.3 2.5e-12 XP_016874279 (OMIM: 608870) PREDICTED: leucine-ric ( 623) 520 73.1 3.2e-12 >>NP_116197 (OMIM: 609791) leucine-rich repeat and immun (620 aa) initn: 4149 init1: 4149 opt: 4149 Z-score: 2530.5 bits: 478.4 E(85289): 3.3e-134 Smith-Waterman score: 4149; 100.0% identity (100.0% similar) in 620 aa overlap (1-620:1-620) 10 20 30 40 50 60 pF1KSD MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR 550 560 570 580 590 600 610 620 pF1KSD KSDAGISSADAPRKFNMKMI :::::::::::::::::::: NP_116 KSDAGISSADAPRKFNMKMI 610 620 >>NP_001288123 (OMIM: 609791) leucine-rich repeat and im (614 aa) initn: 4112 init1: 4112 opt: 4112 Z-score: 2508.2 bits: 474.2 E(85289): 5.7e-133 Smith-Waterman score: 4112; 100.0% identity (100.0% similar) in 614 aa overlap (7-620:1-614) 10 20 30 40 50 60 pF1KSD MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK 10 20 30 40 50 70 80 90 100 110 120 pF1KSD RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KSD LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KSD YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KSD LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS 240 250 260 270 280 290 310 320 330 340 350 360 pF1KSD TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN 300 310 320 330 340 350 370 380 390 400 410 420 pF1KSD LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT 360 370 380 390 400 410 430 440 450 460 470 480 pF1KSD CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG 420 430 440 450 460 470 490 500 510 520 530 540 pF1KSD TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE 480 490 500 510 520 530 550 560 570 580 590 600 pF1KSD ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR 540 550 560 570 580 590 610 620 pF1KSD KSDAGISSADAPRKFNMKMI :::::::::::::::::::: NP_001 KSDAGISSADAPRKFNMKMI 600 610 >>XP_016878171 (OMIM: 609791) PREDICTED: leucine-rich re (614 aa) initn: 4112 init1: 4112 opt: 4112 Z-score: 2508.2 bits: 474.2 E(85289): 5.7e-133 Smith-Waterman score: 4112; 100.0% identity (100.0% similar) in 614 aa overlap (7-620:1-614) 10 20 30 40 50 60 pF1KSD MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK 10 20 30 40 50 70 80 90 100 110 120 pF1KSD RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KSD LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KSD YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KSD LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS 240 250 260 270 280 290 310 320 330 340 350 360 pF1KSD TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN 300 310 320 330 340 350 370 380 390 400 410 420 pF1KSD LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT 360 370 380 390 400 410 430 440 450 460 470 480 pF1KSD CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG 420 430 440 450 460 470 490 500 510 520 530 540 pF1KSD TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE 480 490 500 510 520 530 550 560 570 580 590 600 pF1KSD ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR 540 550 560 570 580 590 610 620 pF1KSD KSDAGISSADAPRKFNMKMI :::::::::::::::::::: XP_016 KSDAGISSADAPRKFNMKMI 600 610 >>NP_001288128 (OMIM: 609791) leucine-rich repeat and im (614 aa) initn: 4112 init1: 4112 opt: 4112 Z-score: 2508.2 bits: 474.2 E(85289): 5.7e-133 Smith-Waterman score: 4112; 100.0% identity (100.0% similar) in 614 aa overlap (7-620:1-614) 10 20 30 40 50 60 pF1KSD MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK 10 20 30 40 50 70 80 90 100 110 120 pF1KSD RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KSD LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KSD YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KSD LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS 240 250 260 270 280 290 310 320 330 340 350 360 pF1KSD TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN 300 310 320 330 340 350 370 380 390 400 410 420 pF1KSD LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT 360 370 380 390 400 410 430 440 450 460 470 480 pF1KSD CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG 420 430 440 450 460 470 490 500 510 520 530 540 pF1KSD TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE 480 490 500 510 520 530 550 560 570 580 590 600 pF1KSD ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR 540 550 560 570 580 590 610 620 pF1KSD KSDAGISSADAPRKFNMKMI :::::::::::::::::::: NP_001 KSDAGISSADAPRKFNMKMI 600 610 >>NP_001288124 (OMIM: 609791) leucine-rich repeat and im (614 aa) initn: 4112 init1: 4112 opt: 4112 Z-score: 2508.2 bits: 474.2 E(85289): 5.7e-133 Smith-Waterman score: 4112; 100.0% identity (100.0% similar) in 614 aa overlap (7-620:1-614) 10 20 30 40 50 60 pF1KSD MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK 10 20 30 40 50 70 80 90 100 110 120 pF1KSD RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KSD LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KSD YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KSD LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS 240 250 260 270 280 290 310 320 330 340 350 360 pF1KSD TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN 300 310 320 330 340 350 370 380 390 400 410 420 pF1KSD LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT 360 370 380 390 400 410 430 440 450 460 470 480 pF1KSD CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG 420 430 440 450 460 470 490 500 510 520 530 540 pF1KSD TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE 480 490 500 510 520 530 550 560 570 580 590 600 pF1KSD ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR 540 550 560 570 580 590 610 620 pF1KSD KSDAGISSADAPRKFNMKMI :::::::::::::::::::: NP_001 KSDAGISSADAPRKFNMKMI 600 610 >>XP_011520420 (OMIM: 609791) PREDICTED: leucine-rich re (614 aa) initn: 4112 init1: 4112 opt: 4112 Z-score: 2508.2 bits: 474.2 E(85289): 5.7e-133 Smith-Waterman score: 4112; 100.0% identity (100.0% similar) in 614 aa overlap (7-620:1-614) 10 20 30 40 50 60 pF1KSD MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK 10 20 30 40 50 70 80 90 100 110 120 pF1KSD RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KSD LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KSD YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KSD LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS 240 250 260 270 280 290 310 320 330 340 350 360 pF1KSD TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN 300 310 320 330 340 350 370 380 390 400 410 420 pF1KSD LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT 360 370 380 390 400 410 430 440 450 460 470 480 pF1KSD CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG 420 430 440 450 460 470 490 500 510 520 530 540 pF1KSD TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE 480 490 500 510 520 530 550 560 570 580 590 600 pF1KSD ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR 540 550 560 570 580 590 610 620 pF1KSD KSDAGISSADAPRKFNMKMI :::::::::::::::::::: XP_011 KSDAGISSADAPRKFNMKMI 600 610 >>NP_001288129 (OMIM: 609791) leucine-rich repeat and im (614 aa) initn: 4112 init1: 4112 opt: 4112 Z-score: 2508.2 bits: 474.2 E(85289): 5.7e-133 Smith-Waterman score: 4112; 100.0% identity (100.0% similar) in 614 aa overlap (7-620:1-614) 10 20 30 40 50 60 pF1KSD MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK 10 20 30 40 50 70 80 90 100 110 120 pF1KSD RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KSD LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KSD YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KSD LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS 240 250 260 270 280 290 310 320 330 340 350 360 pF1KSD TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN 300 310 320 330 340 350 370 380 390 400 410 420 pF1KSD LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT 360 370 380 390 400 410 430 440 450 460 470 480 pF1KSD CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG 420 430 440 450 460 470 490 500 510 520 530 540 pF1KSD TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE 480 490 500 510 520 530 550 560 570 580 590 600 pF1KSD ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR 540 550 560 570 580 590 610 620 pF1KSD KSDAGISSADAPRKFNMKMI :::::::::::::::::::: NP_001 KSDAGISSADAPRKFNMKMI 600 610 >>NP_001288126 (OMIM: 609791) leucine-rich repeat and im (614 aa) initn: 4112 init1: 4112 opt: 4112 Z-score: 2508.2 bits: 474.2 E(85289): 5.7e-133 Smith-Waterman score: 4112; 100.0% identity (100.0% similar) in 614 aa overlap (7-620:1-614) 10 20 30 40 50 60 pF1KSD MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK 10 20 30 40 50 70 80 90 100 110 120 pF1KSD RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KSD LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KSD YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KSD LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS 240 250 260 270 280 290 310 320 330 340 350 360 pF1KSD TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN 300 310 320 330 340 350 370 380 390 400 410 420 pF1KSD LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT 360 370 380 390 400 410 430 440 450 460 470 480 pF1KSD CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG 420 430 440 450 460 470 490 500 510 520 530 540 pF1KSD TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE 480 490 500 510 520 530 550 560 570 580 590 600 pF1KSD ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR 540 550 560 570 580 590 610 620 pF1KSD KSDAGISSADAPRKFNMKMI :::::::::::::::::::: NP_001 KSDAGISSADAPRKFNMKMI 600 610 >>NP_001288115 (OMIM: 609791) leucine-rich repeat and im (614 aa) initn: 4112 init1: 4112 opt: 4112 Z-score: 2508.2 bits: 474.2 E(85289): 5.7e-133 Smith-Waterman score: 4112; 100.0% identity (100.0% similar) in 614 aa overlap (7-620:1-614) 10 20 30 40 50 60 pF1KSD MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK 10 20 30 40 50 70 80 90 100 110 120 pF1KSD RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KSD LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KSD YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KSD LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS 240 250 260 270 280 290 310 320 330 340 350 360 pF1KSD TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN 300 310 320 330 340 350 370 380 390 400 410 420 pF1KSD LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT 360 370 380 390 400 410 430 440 450 460 470 480 pF1KSD CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG 420 430 440 450 460 470 490 500 510 520 530 540 pF1KSD TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE 480 490 500 510 520 530 550 560 570 580 590 600 pF1KSD ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR 540 550 560 570 580 590 610 620 pF1KSD KSDAGISSADAPRKFNMKMI :::::::::::::::::::: NP_001 KSDAGISSADAPRKFNMKMI 600 610 >>NP_001288120 (OMIM: 609791) leucine-rich repeat and im (614 aa) initn: 4112 init1: 4112 opt: 4112 Z-score: 2508.2 bits: 474.2 E(85289): 5.7e-133 Smith-Waterman score: 4112; 100.0% identity (100.0% similar) in 614 aa overlap (7-620:1-614) 10 20 30 40 50 60 pF1KSD MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK 10 20 30 40 50 70 80 90 100 110 120 pF1KSD RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KSD LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KSD YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR 180 190 200 210 220 230 250 260 270 280 290 300 pF1KSD LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS 240 250 260 270 280 290 310 320 330 340 350 360 pF1KSD TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN 300 310 320 330 340 350 370 380 390 400 410 420 pF1KSD LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT 360 370 380 390 400 410 430 440 450 460 470 480 pF1KSD CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG 420 430 440 450 460 470 490 500 510 520 530 540 pF1KSD TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE 480 490 500 510 520 530 550 560 570 580 590 600 pF1KSD ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR 540 550 560 570 580 590 610 620 pF1KSD KSDAGISSADAPRKFNMKMI :::::::::::::::::::: NP_001 KSDAGISSADAPRKFNMKMI 600 610 620 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 08:16:47 2016 done: Thu Nov 3 08:16:48 2016 Total Scan time: 8.140 Total Display time: 0.140 Function used was FASTA [36.3.4 Apr, 2011]