FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDB0061, 1098 aa 1>>>pF1KSDB0061 1098 - 1098 aa - 1098 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.3617+/-0.000597; mu= -5.9591+/- 0.037 mean_var=411.2754+/-88.740, 0's: 0 Z-trim(116.7): 252 B-trim: 38 in 1/54 Lambda= 0.063242 statistics sampled from 27868 (28134) to 27868 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.33), width: 16 Scan time: 14.960 The best scores are: opt bits E(85289) NP_036467 (OMIM: 601480) unconventional myosin-If (1098) 7388 690.0 2e-197 XP_016882310 (OMIM: 601480) PREDICTED: unconventio (1094) 7346 686.2 2.8e-196 XP_011526328 (OMIM: 601480) PREDICTED: unconventio (1090) 5836 548.4 8.5e-155 NP_004989 (OMIM: 601479,614131) unconventional myo (1108) 5358 504.8 1.2e-141 XP_011526326 (OMIM: 601480) PREDICTED: unconventio (1119) 3997 380.6 2.8e-104 XP_011526330 (OMIM: 601480) PREDICTED: unconventio ( 573) 3369 323.0 3.1e-87 XP_011526329 (OMIM: 601480) PREDICTED: unconventio (1074) 3369 323.3 4.8e-87 XP_011526327 (OMIM: 601480) PREDICTED: unconventio (1115) 3182 306.3 6.7e-82 NP_001094891 (OMIM: 614636) unconventional myosin- (1022) 2004 198.7 1.4e-49 XP_016874696 (OMIM: 614636) PREDICTED: unconventio (1027) 2004 198.7 1.4e-49 XP_011536525 (OMIM: 614636) PREDICTED: unconventio (1044) 1790 179.2 1.1e-43 NP_001120651 (OMIM: 276900,276903,600060,601317) u (1178) 1639 165.5 1.7e-39 XP_016873276 (OMIM: 276900,276903,600060,601317) P (1451) 1639 165.6 2e-39 XP_016873275 (OMIM: 276900,276903,600060,601317) P (2154) 1639 165.7 2.6e-39 NP_001120652 (OMIM: 276900,276903,600060,601317) u (2175) 1639 165.7 2.6e-39 XP_016873273 (OMIM: 276900,276903,600060,601317) P (2206) 1639 165.7 2.6e-39 XP_016873277 (OMIM: 276900,276903,600060,601317) P (2207) 1639 165.7 2.6e-39 NP_000251 (OMIM: 276900,276903,600060,601317) unco (2215) 1639 165.7 2.6e-39 XP_016873272 (OMIM: 276900,276903,600060,601317) P (2219) 1639 165.7 2.6e-39 XP_016873271 (OMIM: 276900,276903,600060,601317) P (2220) 1639 165.7 2.6e-39 XP_016873270 (OMIM: 276900,276903,600060,601317) P (2226) 1639 165.7 2.7e-39 XP_011543346 (OMIM: 276900,276903,600060,601317) P (2228) 1639 165.7 2.7e-39 XP_016873269 (OMIM: 276900,276903,600060,601317) P (2245) 1639 165.8 2.7e-39 XP_016873268 (OMIM: 276900,276903,600060,601317) P (2255) 1639 165.8 2.7e-39 XP_016873267 (OMIM: 276900,276903,600060,601317) P (2256) 1639 165.8 2.7e-39 XP_011543348 (OMIM: 276900,276903,600060,601317) P (2258) 1639 165.8 2.7e-39 XP_011543352 (OMIM: 276900,276903,600060,601317) P (2140) 1576 160.0 1.4e-37 NP_036355 (OMIM: 606537) unconventional myosin-Ib (1078) 1461 149.2 1.2e-34 NP_001317166 (OMIM: 606537) unconventional myosin- (1107) 1461 149.2 1.2e-34 NP_001317167 (OMIM: 606537) unconventional myosin- (1107) 1461 149.2 1.2e-34 NP_001123630 (OMIM: 606537) unconventional myosin- (1136) 1461 149.2 1.3e-34 NP_001155291 (OMIM: 606537) unconventional myosin- (1136) 1461 149.2 1.3e-34 XP_005246629 (OMIM: 606537) PREDICTED: unconventio (1136) 1461 149.2 1.3e-34 NP_203693 (OMIM: 606538) unconventional myosin-Ic (1028) 1438 147.1 5.1e-34 NP_001074419 (OMIM: 606538) unconventional myosin- (1044) 1438 147.1 5.1e-34 NP_001074248 (OMIM: 606538) unconventional myosin- (1063) 1438 147.1 5.2e-34 NP_036466 (OMIM: 601481) unconventional myosin-X [ (2058) 1393 143.3 1.4e-32 XP_016877897 (OMIM: 610022) PREDICTED: unconventio (1697) 1356 139.8 1.3e-31 XP_011520083 (OMIM: 610022) PREDICTED: unconventio (1714) 1353 139.5 1.6e-31 NP_061198 (OMIM: 610022) unconventional myosin-Vc (1742) 1353 139.6 1.6e-31 NP_001073996 (OMIM: 606541) unconventional myosin- (2116) 1343 138.7 3.5e-31 XP_006712602 (OMIM: 606541) PREDICTED: unconventio (2142) 1343 138.7 3.5e-31 XP_011509520 (OMIM: 606541) PREDICTED: unconventio (2145) 1343 138.7 3.5e-31 XP_016859658 (OMIM: 606541) PREDICTED: unconventio (2164) 1343 138.7 3.5e-31 XP_011536675 (OMIM: 601478,607841) PREDICTED: unco ( 866) 1331 137.3 3.9e-31 NP_005370 (OMIM: 601478,607841) unconventional myo (1043) 1331 137.3 4.4e-31 NP_001242970 (OMIM: 601478,607841) unconventional (1043) 1331 137.3 4.4e-31 NP_057323 (OMIM: 600316,602666) unconventional myo (3530) 1342 138.8 5.3e-31 XP_016880204 (OMIM: 600316,602666) PREDICTED: unco (3531) 1336 138.3 7.8e-31 XP_011522220 (OMIM: 600316,602666) PREDICTED: unco (2117) 1328 137.4 8.9e-31 >>NP_036467 (OMIM: 601480) unconventional myosin-If [Hom (1098 aa) initn: 7388 init1: 7388 opt: 7388 Z-score: 3665.4 bits: 690.0 E(85289): 2e-197 Smith-Waterman score: 7388; 99.9% identity (99.9% similar) in 1098 aa overlap (1-1098:1-1098) 10 20 30 40 50 60 pF1KSD MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD AEQEEYVQAGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 AEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD QKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 QKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD RMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 RMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KSD VKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQHLLRAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 VKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQHLLRAV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KSD NMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMREEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 NMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMREEA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KSD SNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKRERVDFADSVTKYDRRFKPIKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKRERVDFADSVTKYDRRFKPIKR 730 740 750 760 770 780 790 800 810 820 830 840 pF1KSD DLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFILQEDAAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 DLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFILQEDAAD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KSD SFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSVTFSRGFGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSVTFSRGFGD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KSD LAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSSQAPTRAAPAPPRGMDRNGVPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSSQAPTRAAPAPPRGMDRNGVPP 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KSD SARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARPPSEHNTEFLNVPDQGMAGMQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 SARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARPPSEHNTEFLNVPDQGMAGMQR 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KSD KRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDELSFNVNEVIEILMEDPSGWWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 KRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDELSFNVNEVIEILMEDPSGWWK 1030 1040 1050 1060 1070 1080 1090 pF1KSD GRLHGQEGLFPGNYVEKI :::::::::::::::::: NP_036 GRLHGQEGLFPGNYVEKI 1090 >>XP_016882310 (OMIM: 601480) PREDICTED: unconventional (1094 aa) initn: 5646 init1: 5646 opt: 7346 Z-score: 3644.7 bits: 686.2 E(85289): 2.8e-196 Smith-Waterman score: 7346; 99.5% identity (99.5% similar) in 1098 aa overlap (1-1098:1-1094) 10 20 30 40 50 60 pF1KSD MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV ::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: XP_016 TYQVDGTDDRSDFGETL----VIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV 250 260 270 280 290 310 320 330 340 350 360 pF1KSD DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR 300 310 320 330 340 350 370 380 390 400 410 420 pF1KSD LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK 360 370 380 390 400 410 430 440 450 460 470 480 pF1KSD AEQEEYVQAGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL 420 430 440 450 460 470 490 500 510 520 530 540 pF1KSD QKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFL 480 490 500 510 520 530 550 560 570 580 590 600 pF1KSD RMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENR 540 550 560 570 580 590 610 620 630 640 650 660 pF1KSD VKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQHLLRAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQHLLRAV 600 610 620 630 640 650 670 680 690 700 710 720 pF1KSD NMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMREEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMREEA 660 670 680 690 700 710 730 740 750 760 770 780 pF1KSD SNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKRERVDFADSVTKYDRRFKPIKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKRERVDFADSVTKYDRRFKPIKR 720 730 740 750 760 770 790 800 810 820 830 840 pF1KSD DLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFILQEDAAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFILQEDAAD 780 790 800 810 820 830 850 860 870 880 890 900 pF1KSD SFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSVTFSRGFGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSVTFSRGFGD 840 850 860 870 880 890 910 920 930 940 950 960 pF1KSD LAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSSQAPTRAAPAPPRGMDRNGVPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSSQAPTRAAPAPPRGMDRNGVPP 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KSD SARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARPPSEHNTEFLNVPDQGMAGMQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARPPSEHNTEFLNVPDQGMAGMQR 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KSD KRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDELSFNVNEVIEILMEDPSGWWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDELSFNVNEVIEILMEDPSGWWK 1020 1030 1040 1050 1060 1070 1090 pF1KSD GRLHGQEGLFPGNYVEKI :::::::::::::::::: XP_016 GRLHGQEGLFPGNYVEKI 1080 1090 >>XP_011526328 (OMIM: 601480) PREDICTED: unconventional (1090 aa) initn: 5956 init1: 3182 opt: 5836 Z-score: 2900.1 bits: 548.4 E(85289): 8.5e-155 Smith-Waterman score: 6861; 93.1% identity (94.0% similar) in 1119 aa overlap (1-1098:1-1090) 10 20 30 40 50 60 pF1KSD MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD AEQEEYVQAGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL ::: :::::::::::::::::::::::::::: XP_011 AEQ-----------------------------SPPGIMSVLDDVCATMHATGGGADQTLL 430 440 450 490 500 510 520 530 540 pF1KSD QKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFL 460 470 480 490 500 510 550 560 570 580 590 600 pF1KSD RMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENR 520 530 540 550 560 570 610 620 630 pF1KSD V------------KHQVEYLGLKENIRVRRAGFAYRRQFAKFLQ---------RYAILTP . :: . : . . .. : : .. .. ::::::: XP_011 TGDSPPRGDSAYPPHQSQAPGGIPGPEGEHQGAQSRLRLPPPVRQIPAEPSALRYAILTP 580 590 600 610 620 630 640 650 660 670 680 690 pF1KSD ETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFART :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFART 640 650 660 670 680 690 700 710 720 730 740 750 pF1KSD IQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKR 700 710 720 730 740 750 760 770 780 790 800 810 pF1KSD ERVDFADSVTKYDRRFKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERVDFADSVTKYDRRFKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQAL 760 770 780 790 800 810 820 830 840 850 860 870 pF1KSD RGVSLSTRQDDFFILQEDAADSFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGVSLSTRQDDFFILQEDAADSFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRV 820 830 840 850 860 870 880 890 900 910 920 930 pF1KSD KKEGWGGGGTRSVTFSRGFGDLAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKEGWGGGGTRSVTFSRGFGDLAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSS 880 890 900 910 920 930 940 950 960 970 980 990 pF1KSD QAPTRAAPAPPRGMDRNGVPPSARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QAPTRAAPAPPRGMDRNGVPPSARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARP 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 pF1KSD PSEHNTEFLNVPDQGMAGMQRKRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSEHNTEFLNVPDQGMAGMQRKRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDE 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 pF1KSD LSFNVNEVIEILMEDPSGWWKGRLHGQEGLFPGNYVEKI ::::::::::::::::::::::::::::::::::::::: XP_011 LSFNVNEVIEILMEDPSGWWKGRLHGQEGLFPGNYVEKI 1060 1070 1080 1090 >>NP_004989 (OMIM: 601479,614131) unconventional myosin- (1108 aa) initn: 5332 init1: 4731 opt: 5358 Z-score: 2664.3 bits: 504.8 E(85289): 1.2e-141 Smith-Waterman score: 5362; 71.6% identity (87.6% similar) in 1116 aa overlap (1-1098:1-1108) 10 20 30 40 50 pF1KSD MGSK--ERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVN :::: ..::::::::.::::::::: .:::..:. ::.::.::::::::::::::::: NP_004 MGSKGVYQYHWQSHNVKHSGVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KSD PFKQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTV :::::::: ..::..::::::::::::::::.:::::::.:: ::::::::::::::::: NP_004 PFKQMPYFGEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KSD AAKYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSR ::::::.:::.::::: :::::::::::::::::::::::::::::::::::::::::: NP_004 AAKYIMSYISRVSGGGTKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KSD GGEPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQ :::::::::::::::::::::.: .::.:::.:::.:::: ::...::. . ::::::. NP_004 GGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASAEQKHSLGITSMDYYYYLSL 190 200 210 220 230 240 240 250 260 270 280 290 pF1KSD SDTYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVE : .:.:: ::: .: ::: ::.:::: : ::::.:::::::::::: : :::: :: NP_004 SGSYKVDDIDDRREFQETLHAMNVIGIFAEEQTLVLQIVAGILHLGNISFKEVGNYAAVE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KSD SVDLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLY : ..::::::::::.. ::.::::::.:::.:::.::::.:::::::: ::::::::.:. NP_004 SEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESIHVTLNVEQACYTRDALAKALH 310 320 330 340 350 360 360 370 380 390 400 410 pF1KSD ARLFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELT ::.:::::..::.::.: .:::.::::::::::::::::::::::::::::::::::::: NP_004 ARVFDFLVDSINKAMEKDHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELT 370 380 390 400 410 420 420 430 440 450 460 470 pF1KSD LKAEQEEYVQAGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQT :::::::::: :::::::.:::::.::::::::..::::::.::::::::::.: ::::: NP_004 LKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQT 430 440 450 460 470 480 480 490 500 510 520 530 pF1KSD LLQKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQA :::::: .:.:::::::. ::.:::::::::::..::::::::::: :::::::.:: NP_004 LLQKLQMQIGSHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSELP 490 500 510 520 530 540 540 550 560 570 580 590 pF1KSD FLRMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEE :.. ::::.:..::::::.::::::::::::::.:::.:::::::::::::::.:::::: NP_004 FIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPRDWEE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KSD NRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQHLLR .:::::::::::::::::::::.:::: : :::::::::: ::: :.:.:.::: :::. NP_004 SRVKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGEEKQGVLHLLQ 610 620 630 640 650 660 660 670 680 690 700 710 pF1KSD AVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMRE .:::. ::.:.: .:::.: :::::::::.::::.::.::.:::.::. :: .:: .::: NP_004 SVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMRE 670 680 690 700 710 720 720 730 740 750 760 770 pF1KSD EASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKRERVDFADSVTKYDRRFKPI :::..::::::::::::::::.:::.:.::.:::.::.::::..::::.::::::::: . NP_004 EASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKGV 730 740 750 760 770 780 780 790 800 810 820 830 pF1KSD KRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFILQEDA ::::.:::::.:.:::::::.::.:: : ::::.:..:. . .::::: :::.:::.:. NP_004 KRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRKIEIERILSVSLSTMQDDIFILHEQE 790 800 810 820 830 840 840 850 860 870 880 890 pF1KSD ADSFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWG---GGGTRSVTFS ::.:::::::::.::: ::.:: :.. ::: ::.::....:::.:: .::.:.: : NP_004 YDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGGSRQVQFH 850 860 870 880 890 900 900 910 920 930 940 950 pF1KSD RGFGDLAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRS----SQAPTRAAPAPPR .::::::::: ....: ::.: ::::.:.:::.. ... : .. :.:::: :: NP_004 QGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRRNTTQNTGYSSGTQNANYPVRAAPPPP- 910 920 930 940 950 960 970 980 990 1000 pF1KSD GMDRNGV------P-PSARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARPPSEHN :. .::: : : : :. . . ::: : . .: : : : NP_004 GYHQNGVIRNQYVPYPHAPGSQRSNQKSLYTSMARPPL--PRQQSTSSDRVSQTPES--- 960 970 980 990 1000 1010 1010 1020 1030 1040 1050 1060 pF1KSD TEFLNVPDQGMAGMQRKRSVGQRPVPGVGRPKPQPRTHG--PRCRALYQYVGQDVDELSF .::.::::: ::..:. . .:: :. :::::::. . :.:.::: : .::.::::: NP_004 LDFLKVPDQGAAGVRRQTT--SRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSF 1020 1030 1040 1050 1060 1070 1070 1080 1090 pF1KSD NVNEVIEILMEDPSGWWKGRLHGQEGLFPGNYVEKI :.:..:.:. ::::::: :::.:..::::.::: :: NP_004 NANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI 1080 1090 1100 >>XP_011526326 (OMIM: 601480) PREDICTED: unconventional (1119 aa) initn: 7165 init1: 3997 opt: 3997 Z-score: 1993.2 bits: 380.6 E(85289): 2.8e-104 Smith-Waterman score: 7123; 95.6% identity (96.5% similar) in 1119 aa overlap (1-1098:1-1119) 10 20 30 40 50 60 pF1KSD MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD AEQEEYVQAGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD QKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KSD RMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENR 550 560 570 580 590 600 610 620 630 pF1KSD V------------KHQVEYLGLKENIRVRRAGFAYRRQFAKFLQ---------RYAILTP . :: . : . . .. : : .. .. ::::::: XP_011 TGDSPPRGDSAYPPHQSQAPGGIPGPEGEHQGAQSRLRLPPPVRQIPAEPSALRYAILTP 610 620 630 640 650 660 640 650 660 670 680 690 pF1KSD ETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFART :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFART 670 680 690 700 710 720 700 710 720 730 740 750 pF1KSD IQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKR 730 740 750 760 770 780 760 770 780 790 800 810 pF1KSD ERVDFADSVTKYDRRFKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERVDFADSVTKYDRRFKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQAL 790 800 810 820 830 840 820 830 840 850 860 870 pF1KSD RGVSLSTRQDDFFILQEDAADSFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGVSLSTRQDDFFILQEDAADSFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRV 850 860 870 880 890 900 880 890 900 910 920 930 pF1KSD KKEGWGGGGTRSVTFSRGFGDLAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKEGWGGGGTRSVTFSRGFGDLAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSS 910 920 930 940 950 960 940 950 960 970 980 990 pF1KSD QAPTRAAPAPPRGMDRNGVPPSARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QAPTRAAPAPPRGMDRNGVPPSARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARP 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KSD PSEHNTEFLNVPDQGMAGMQRKRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSEHNTEFLNVPDQGMAGMQRKRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDE 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 pF1KSD LSFNVNEVIEILMEDPSGWWKGRLHGQEGLFPGNYVEKI ::::::::::::::::::::::::::::::::::::::: XP_011 LSFNVNEVIEILMEDPSGWWKGRLHGQEGLFPGNYVEKI 1090 1100 1110 >>XP_011526330 (OMIM: 601480) PREDICTED: unconventional (573 aa) initn: 3369 init1: 3369 opt: 3369 Z-score: 1687.3 bits: 323.0 E(85289): 3.1e-87 Smith-Waterman score: 3369; 99.8% identity (99.8% similar) in 508 aa overlap (1-508:1-508) 10 20 30 40 50 60 pF1KSD MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD AEQEEYVQAGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD QKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFL :::::::::::::::::::::::::::: XP_011 QKLQAAVGTHEHFNSWSAGFVIHHYAGKGLPPDALPREAGWRQEGAPQHRRLQDQETSQR 490 500 510 520 530 540 >>XP_011526329 (OMIM: 601480) PREDICTED: unconventional (1074 aa) initn: 6537 init1: 3369 opt: 3369 Z-score: 1683.7 bits: 323.3 E(85289): 4.8e-87 Smith-Waterman score: 6468; 90.2% identity (92.7% similar) in 1099 aa overlap (1-1098:1-1074) 10 20 30 40 50 60 pF1KSD MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KSD LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KSD AEQEEYVQAGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KSD QKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFL :::::::::::::::::::::::::::: :. :.: . .. . : XP_011 QKLQAAVGTHEHFNSWSAGFVIHHYAGK------GLPP---DALPREAGWRQEGAPQH-- 490 500 510 520 550 560 570 580 590 pF1KSD RMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLM-RCTPHYIRCIKPNETKRPRDWEEN : : : . . ::. .... . : : . .:. . .... : XP_011 RRL----QDQETSQRPGGHTDEVHTPLHPLHQTQRDQEAPR----LGGEQSQAPGGIPGP 530 540 550 560 570 580 600 610 620 630 640 650 pF1KSD RVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWPRWRGDERQGVQHLLRA . .:: : . :.: . . ::::::::::::::::::::::::::: XP_011 EGEHQ----GAQS--RLRLPPPVRQIPAEPSALRYAILTPETWPRWRGDERQGVQHLLRA 590 600 610 620 630 660 670 680 690 700 710 pF1KSD VNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMREE 640 650 660 670 680 690 720 730 740 750 760 770 pF1KSD ASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKRERVDFADSVTKYDRRFKPIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKRERVDFADSVTKYDRRFKPIK 700 710 720 730 740 750 780 790 800 810 820 830 pF1KSD RDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFILQEDAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFILQEDAA 760 770 780 790 800 810 840 850 860 870 880 890 pF1KSD DSFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSVTFSRGFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSVTFSRGFG 820 830 840 850 860 870 900 910 920 930 940 950 pF1KSD DLAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSSQAPTRAAPAPPRGMDRNGVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSSQAPTRAAPAPPRGMDRNGVP 880 890 900 910 920 930 960 970 980 990 1000 1010 pF1KSD PSARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARPPSEHNTEFLNVPDQGMAGMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARPPSEHNTEFLNVPDQGMAGMQ 940 950 960 970 980 990 1020 1030 1040 1050 1060 1070 pF1KSD RKRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDELSFNVNEVIEILMEDPSGWW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RKRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDELSFNVNEVIEILMEDPSGWW 1000 1010 1020 1030 1040 1050 1080 1090 pF1KSD KGRLHGQEGLFPGNYVEKI ::::::::::::::::::: XP_011 KGRLHGQEGLFPGNYVEKI 1060 1070 >>XP_011526327 (OMIM: 601480) PREDICTED: unconventional (1115 aa) initn: 5423 init1: 3182 opt: 3182 Z-score: 1591.3 bits: 306.3 E(85289): 6.7e-82 Smith-Waterman score: 7081; 95.3% identity (96.2% similar) in 1119 aa overlap (1-1098:1-1115) 10 20 30 40 50 60 pF1KSD MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD TYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV ::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: XP_011 TYQVDGTDDRSDFGETL----VIGIPPSIQQLVLQLVAGILHLGNISFCEDGNYARVESV 250 260 270 280 290 310 320 330 340 350 360 pF1KSD DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYAR 300 310 320 330 340 350 370 380 390 400 410 420 pF1KSD LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFDFLVEAINRAMQKPQEEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLK 360 370 380 390 400 410 430 440 450 460 470 480 pF1KSD AEQEEYVQAGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AEQEEYVQEGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGADQTLL 420 430 440 450 460 470 490 500 510 520 530 540 pF1KSD QKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKLQAAVGTHEHFNSWSAGFVIHHYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFL 480 490 500 510 520 530 550 560 570 580 590 600 pF1KSD RMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENR 540 550 560 570 580 590 610 620 630 pF1KSD V------------KHQVEYLGLKENIRVRRAGFAYRRQFAKFLQ---------RYAILTP . :: . : . . .. : : .. .. ::::::: XP_011 TGDSPPRGDSAYPPHQSQAPGGIPGPEGEHQGAQSRLRLPPPVRQIPAEPSALRYAILTP 600 610 620 630 640 650 640 650 660 670 680 690 pF1KSD ETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFART :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFART 660 670 680 690 700 710 700 710 720 730 740 750 pF1KSD IQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFVGDYLGLEERPELRQFLGKR 720 730 740 750 760 770 760 770 780 790 800 810 pF1KSD ERVDFADSVTKYDRRFKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERVDFADSVTKYDRRFKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKKVDIQAL 780 790 800 810 820 830 820 830 840 850 860 870 pF1KSD RGVSLSTRQDDFFILQEDAADSFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGVSLSTRQDDFFILQEDAADSFLESVFKTEFVSLLCKRFEEATRRPLPLTFSDTLQFRV 840 850 860 870 880 890 880 890 900 910 920 930 pF1KSD KKEGWGGGGTRSVTFSRGFGDLAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKEGWGGGGTRSVTFSRGFGDLAVLKVGGRTLTVSVGDGLPKSSKPTRKGMAKGKPRRSS 900 910 920 930 940 950 940 950 960 970 980 990 pF1KSD QAPTRAAPAPPRGMDRNGVPPSARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QAPTRAAPAPPRGMDRNGVPPSARGGPLPLEIMSGGGTHRPPRGPPSTSLGASRRPRARP 960 970 980 990 1000 1010 1000 1010 1020 1030 1040 1050 pF1KSD PSEHNTEFLNVPDQGMAGMQRKRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSEHNTEFLNVPDQGMAGMQRKRSVGQRPVPGVGRPKPQPRTHGPRCRALYQYVGQDVDE 1020 1030 1040 1050 1060 1070 1060 1070 1080 1090 pF1KSD LSFNVNEVIEILMEDPSGWWKGRLHGQEGLFPGNYVEKI ::::::::::::::::::::::::::::::::::::::: XP_011 LSFNVNEVIEILMEDPSGWWKGRLHGQEGLFPGNYVEKI 1080 1090 1100 1110 >>NP_001094891 (OMIM: 614636) unconventional myosin-Ih [ (1022 aa) initn: 1618 init1: 919 opt: 2004 Z-score: 1010.9 bits: 198.7 E(85289): 1.4e-49 Smith-Waterman score: 2006; 42.6% identity (73.0% similar) in 760 aa overlap (18-750:12-760) 10 20 30 40 50 pF1KSD MGSKERFHWQSHNVKQSGVDDMVLLPQIT-EDAIAANLRKRFMDDYIFTYIGSVLISVNP ::.:.::: : :.:.. :::::: .. :.::::..:.:::: NP_001 MEGALTARDKVGVQDFVLLDAYTSESAFVDNLRKRFSENLIYTYIGTLLVSVNP 10 20 30 40 50 60 70 80 90 100 110 pF1KSD FKQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVA .... .: ...::::. .: :::.::..:: :: : . .:. ..:::::::::: : NP_001 YQELGIYTVSQMELYQGVNFFELPPHVYAIADNAYRMMCAELNNHFILISGESGAGKTEA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KSD AKYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRG .: :. :.. . ...: ..: .: :::.:::::::.:.::.::::::::..:::. NP_001 SKKILEYFAVTCPMTQSLQIARDRLLFSNPVLEAFGNARTLRNDNSSRFGKYMDIQFDFQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KSD GEPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMT-PDYYYYLNQ : : ::.: ..:.::::::.:::.::::::.:::: :. .:. . ::: :. : ::.: NP_001 GIPVGGHIISYLIEKSRVVYQNEGERNFHIFYQLLAGGEEERLSYLGLERDPQLYKYLSQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KSD SDTYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNY-ARV . . .. .:..:. . .:..:: . . . .. ..:..::::::.: :: . : . NP_001 GHCAKESSISDKNDWKTVSNAFSVIDFTEADLENLFGIIASVLHLGNIGFEEDDQGCATI 240 250 260 270 280 290 300 310 320 330 340 350 pF1KSD ESVDLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGL .. . . : :::. . : : :: ::.... .: . :..: ..:.:::.::.. NP_001 PDTHEIKWIAKLLGVHPSVLLEALTHRKIEAK----TEEVICPLTLELSVYARDAMAKAV 300 310 320 330 340 350 360 370 380 390 400 410 pF1KSD YARLFDFLVEAINRAMQKPQ--EEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFI :.: : .::. :: .. . . .. ::.:::::::.:.::::::::::. ::::::..: NP_001 YGRTFTWLVNKINSSLVNKDFTRKTVIGLLDIYGFEVFDKNGFEQFCINYCNEKLQQLLI 360 370 380 390 400 410 420 430 440 450 460 470 pF1KSD ELTLKAEQEEYVQAGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGA : :::::: :: . ::.: ::.:::::..:::.:.. . ::.:.::. : : .. NP_001 ERTLKAEQAEYEMEGIEWEPIKYFNNKIICDLVEERHK--GIISILDEECIR---PGPAT 420 430 440 450 460 480 490 500 510 520 pF1KSD DQTLLQKLQAAVGTHEHFNSWS-AG-----------FVIHHYAGKVSYDVSGFCERNRDV : ..:.::. :: : ::.. . :: : . ::::.:.: ..:: :.: :. NP_001 DLSFLEKLEEKVGKHAHFETRKLAGPKGRKRIGWMEFRLLHYAGEVTYCTKGFLEKNNDL 470 480 490 500 510 520 530 540 550 560 570 580 pF1KSD LFSDLIELMQTSEQAFLRMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIR :. : :.. :.. .:: : . ... :: :.:...:.. ..:. ::. : ::: NP_001 LYRHLKEVLCKSKNIILRECF-LLAELENRRRPPTVGTQFKNSLSSLLETLISKEPSYIR 530 540 550 560 570 580 590 600 610 620 630 640 pF1KSD CIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWP :::::. :.: ... ..::..:::: :..:::::::::::.. .::::: : :.::: NP_001 CIKPNDRKEPSKFDDFLIRHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWP 590 600 610 620 630 640 650 660 670 680 690 700 pF1KSD RWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKA .:.: .::..:.. ....:..:..:.::.:.. :..:: :.. : . .. :: . NP_001 HWHGPPAEGVERLIKYIGYKPEEYKLGKTKIFIRFPRTLFATEDAFEFSKHQLVARIQAT 650 660 670 680 690 700 710 720 730 740 750 pF1KSD WRRHVAVRKYEEMREEASNI------LLNKK--ERRRNSIN--RNFVGDYLGLEERPELR ..: .. :.: . :. : .. : .: .::. .. :.:. ... ...: NP_001 YKRCLGRREYVKKRQAAIKLEAHWRGALARKAIQRRKWAVRIIRKFIKGFIS-RNKPLCP 710 720 730 740 750 760 760 770 780 790 800 810 pF1KSD QFLGKRERVDFADSVTKYDRRFKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKK NP_001 DNEEFIVFVRKNYILNLRYHLPKTVLDKSWLRPPGILENASDLLRKMCVRNLVQKYCRGI 770 780 790 800 810 820 >>XP_016874696 (OMIM: 614636) PREDICTED: unconventional (1027 aa) initn: 1618 init1: 919 opt: 2004 Z-score: 1010.9 bits: 198.7 E(85289): 1.4e-49 Smith-Waterman score: 2006; 42.6% identity (73.0% similar) in 760 aa overlap (18-750:12-760) 10 20 30 40 50 pF1KSD MGSKERFHWQSHNVKQSGVDDMVLLPQIT-EDAIAANLRKRFMDDYIFTYIGSVLISVNP ::.:.::: : :.:.. :::::: .. :.::::..:.:::: XP_016 MEGALTARDKVGVQDFVLLDAYTSESAFVDNLRKRFSENLIYTYIGTLLVSVNP 10 20 30 40 50 60 70 80 90 100 110 pF1KSD FKQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVA .... .: ...::::. .: :::.::..:: :: : . .:. ..:::::::::: : XP_016 YQELGIYTVSQMELYQGVNFFELPPHVYAIADNAYRMMCAELNNHFILISGESGAGKTEA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KSD AKYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRG .: :. :.. . ...: ..: .: :::.:::::::.:.::.::::::::..:::. XP_016 SKKILEYFAVTCPMTQSLQIARDRLLFSNPVLEAFGNARTLRNDNSSRFGKYMDIQFDFQ 120 130 140 150 160 170 180 190 200 210 220 230 pF1KSD GEPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGASQEQRQNLGLMT-PDYYYYLNQ : : ::.: ..:.::::::.:::.::::::.:::: :. .:. . ::: :. : ::.: XP_016 GIPVGGHIISYLIEKSRVVYQNEGERNFHIFYQLLAGGEEERLSYLGLERDPQLYKYLSQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KSD SDTYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQLVAGILHLGNISFCEDGNY-ARV . . .. .:..:. . .:..:: . . . .. ..:..::::::.: :: . : . XP_016 GHCAKESSISDKNDWKTVSNAFSVIDFTEADLENLFGIIASVLHLGNIGFEEDDQGCATI 240 250 260 270 280 290 300 310 320 330 340 350 pF1KSD ESVDLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGL .. . . : :::. . : : :: ::.... .: . :..: ..:.:::.::.. XP_016 PDTHEIKWIAKLLGVHPSVLLEALTHRKIEAK----TEEVICPLTLELSVYARDAMAKAV 300 310 320 330 340 350 360 370 380 390 400 410 pF1KSD YARLFDFLVEAINRAMQKPQ--EEYSIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFI :.: : .::. :: .. . . .. ::.:::::::.:.::::::::::. ::::::..: XP_016 YGRTFTWLVNKINSSLVNKDFTRKTVIGLLDIYGFEVFDKNGFEQFCINYCNEKLQQLLI 360 370 380 390 400 410 420 430 440 450 460 470 pF1KSD ELTLKAEQEEYVQAGIRWTPIQYFNNKVVCDLIENKLSPPGIMSVLDDVCATMHATGGGA : :::::: :: . ::.: ::.:::::..:::.:.. . ::.:.::. : : .. XP_016 ERTLKAEQAEYEMEGIEWEPIKYFNNKIICDLVEERHK--GIISILDEECIR---PGPAT 420 430 440 450 460 480 490 500 510 520 pF1KSD DQTLLQKLQAAVGTHEHFNSWS-AG-----------FVIHHYAGKVSYDVSGFCERNRDV : ..:.::. :: : ::.. . :: : . ::::.:.: ..:: :.: :. XP_016 DLSFLEKLEEKVGKHAHFETRKLAGPKGRKRIGWMEFRLLHYAGEVTYCTKGFLEKNNDL 470 480 490 500 510 520 530 540 550 560 570 580 pF1KSD LFSDLIELMQTSEQAFLRMLFPEKLDGDKKGRPSTAGSKIKKQANDLVATLMRCTPHYIR :. : :.. :.. .:: : . ... :: :.:...:.. ..:. ::. : ::: XP_016 LYRHLKEVLCKSKNIILRECF-LLAELENRRRPPTVGTQFKNSLSSLLETLISKEPSYIR 530 540 550 560 570 580 590 600 610 620 630 640 pF1KSD CIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYRRQFAKFLQRYAILTPETWP :::::. :.: ... ..::..:::: :..:::::::::::.. .::::: : :.::: XP_016 CIKPNDRKEPSKFDDFLIRHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWP 590 600 610 620 630 640 650 660 670 680 690 700 pF1KSD RWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEVRERKFDGFARTIQKA .:.: .::..:.. ....:..:..:.::.:.. :..:: :.. : . .. :: . XP_016 HWHGPPAEGVERLIKYIGYKPEEYKLGKTKIFIRFPRTLFATEDAFEFSKHQLVARIQAT 650 660 670 680 690 700 710 720 730 740 750 pF1KSD WRRHVAVRKYEEMREEASNI------LLNKK--ERRRNSIN--RNFVGDYLGLEERPELR ..: .. :.: . :. : .. : .: .::. .. :.:. ... ...: XP_016 YKRCLGRREYVKKRQAAIKLEAHWRGALARKAIQRRKWAVRIIRKFIKGFIS-RNKPLCP 710 720 730 740 750 760 760 770 780 790 800 810 pF1KSD QFLGKRERVDFADSVTKYDRRFKPIKRDLILTPKCVYVIGREKVKKGPEKGQVCEVLKKK XP_016 DNEEFIVFVRKNYILNLRYHLPKTVLDKSWLRPPGILENASDLLRKMCVRNLVQKYCRGI 770 780 790 800 810 820 1098 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 08:26:59 2016 done: Thu Nov 3 08:27:01 2016 Total Scan time: 14.960 Total Display time: 0.430 Function used was FASTA [36.3.4 Apr, 2011]