FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KSDB2506, 403 aa 1>>>pF1KSDB2506 403 - 403 aa - 403 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4763+/-0.000418; mu= 16.4649+/- 0.026 mean_var=80.4193+/-16.332, 0's: 0 Z-trim(112.5): 89 B-trim: 931 in 1/51 Lambda= 0.143019 statistics sampled from 21370 (21459) to 21370 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.613), E-opt: 0.2 (0.252), width: 16 Scan time: 8.610 The best scores are: opt bits E(85289) XP_006721114 (OMIM: 605948) PREDICTED: G-protein c ( 403) 2696 566.2 4.9e-161 NP_057319 (OMIM: 605948) G-protein coupled recepto ( 403) 2696 566.2 4.9e-161 XP_006721115 (OMIM: 605948) PREDICTED: G-protein c ( 403) 2696 566.2 4.9e-161 NP_001291700 (OMIM: 605948) G-protein coupled rece ( 534) 2696 566.3 6.1e-161 XP_016875071 (OMIM: 607437) PREDICTED: G-protein c ( 345) 671 148.4 2.6e-35 NP_061124 (OMIM: 607437) G-protein coupled recepto ( 345) 671 148.4 2.6e-35 XP_005253478 (OMIM: 607437) PREDICTED: G-protein c ( 345) 671 148.4 2.6e-35 XP_016875072 (OMIM: 607437) PREDICTED: G-protein c ( 300) 652 144.4 3.5e-34 NP_003970 (OMIM: 604138) retinoic acid-induced pro ( 357) 652 144.4 4e-34 NP_061123 (OMIM: 605949) G-protein coupled recepto ( 453) 541 121.6 3.8e-27 NP_071319 (OMIM: 605949) G-protein coupled recepto ( 486) 541 121.6 4e-27 XP_005257571 (OMIM: 605949) PREDICTED: G-protein c ( 496) 541 121.6 4.1e-27 XP_016880345 (OMIM: 605949) PREDICTED: G-protein c ( 541) 541 121.7 4.4e-27 XP_016880344 (OMIM: 605949) PREDICTED: G-protein c ( 542) 541 121.7 4.4e-27 XP_005257569 (OMIM: 605949) PREDICTED: G-protein c ( 551) 541 121.7 4.4e-27 XP_011531946 (OMIM: 604099) PREDICTED: metabotropi ( 403) 217 54.7 4.6e-07 XP_011531947 (OMIM: 604099) PREDICTED: metabotropi ( 403) 217 54.7 4.6e-07 XP_011531945 (OMIM: 604099) PREDICTED: metabotropi ( 440) 217 54.8 5e-07 XP_011531949 (OMIM: 604099) PREDICTED: metabotropi ( 459) 217 54.8 5.1e-07 XP_011531948 (OMIM: 604099) PREDICTED: metabotropi ( 494) 217 54.8 5.4e-07 XP_011531941 (OMIM: 604099) PREDICTED: metabotropi ( 678) 217 54.9 7e-07 XP_011531943 (OMIM: 604099) PREDICTED: metabotropi ( 678) 217 54.9 7e-07 XP_011531939 (OMIM: 604099) PREDICTED: metabotropi ( 678) 217 54.9 7e-07 XP_011531940 (OMIM: 604099) PREDICTED: metabotropi ( 678) 217 54.9 7e-07 XP_011531942 (OMIM: 604099) PREDICTED: metabotropi ( 678) 217 54.9 7e-07 XP_011531938 (OMIM: 604099) PREDICTED: metabotropi ( 690) 217 54.9 7.1e-07 XP_011531937 (OMIM: 604099) PREDICTED: metabotropi ( 840) 217 55.0 8.2e-07 XP_016861760 (OMIM: 604099) PREDICTED: metabotropi ( 872) 217 55.0 8.5e-07 NP_000830 (OMIM: 604099) metabotropic glutamate re ( 872) 217 55.0 8.5e-07 NP_000831 (OMIM: 601115) metabotropic glutamate re ( 879) 192 49.8 3e-05 XP_011514410 (OMIM: 601116) PREDICTED: metabotropi ( 552) 163 43.7 0.0013 XP_011514405 (OMIM: 601116) PREDICTED: metabotropi ( 629) 163 43.7 0.0015 XP_016867569 (OMIM: 601116) PREDICTED: metabotropi ( 629) 163 43.7 0.0015 XP_016867567 (OMIM: 601116) PREDICTED: metabotropi ( 703) 163 43.8 0.0016 XP_016867568 (OMIM: 601116) PREDICTED: metabotropi ( 703) 163 43.8 0.0016 XP_016867566 (OMIM: 601116) PREDICTED: metabotropi ( 703) 163 43.8 0.0016 XP_016867564 (OMIM: 601116) PREDICTED: metabotropi ( 703) 163 43.8 0.0016 XP_016867565 (OMIM: 601116) PREDICTED: metabotropi ( 703) 163 43.8 0.0016 XP_011514404 (OMIM: 601116) PREDICTED: metabotropi ( 703) 163 43.8 0.0016 XP_011514403 (OMIM: 601116) PREDICTED: metabotropi ( 703) 163 43.8 0.0016 XP_011514397 (OMIM: 601116) PREDICTED: metabotropi ( 714) 163 43.8 0.0016 XP_011514396 (OMIM: 601116) PREDICTED: metabotropi ( 747) 163 43.8 0.0017 XP_006716001 (OMIM: 601116) PREDICTED: metabotropi ( 908) 163 43.8 0.002 XP_011514394 (OMIM: 601116) PREDICTED: metabotropi ( 908) 163 43.8 0.002 NP_000836 (OMIM: 601116) metabotropic glutamate re ( 908) 163 43.8 0.002 XP_016867563 (OMIM: 601116) PREDICTED: metabotropi ( 908) 163 43.8 0.002 NP_001120795 (OMIM: 601116) metabotropic glutamate ( 908) 163 43.8 0.002 XP_011514393 (OMIM: 601116) PREDICTED: metabotropi ( 908) 163 43.8 0.002 NP_001123535 (OMIM: 604099) metabotropic glutamate ( 254) 156 42.0 0.002 XP_005247894 (OMIM: 145980,239200,601198,601199,61 ( 917) 161 43.4 0.0027 >>XP_006721114 (OMIM: 605948) PREDICTED: G-protein coupl (403 aa) initn: 2696 init1: 2696 opt: 2696 Z-score: 3012.1 bits: 566.2 E(85289): 4.9e-161 Smith-Waterman score: 2696; 100.0% identity (100.0% similar) in 403 aa overlap (1-403:1-403) 10 20 30 40 50 60 pF1KSD MFVASERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MFVASERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD AVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDET 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD ICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD LVLTVLRDTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVLTVLRDTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD FLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD QENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPS 310 320 330 340 350 360 370 380 390 400 pF1KSD GSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW ::::::::::::::::::::::::::::::::::::::::::: XP_006 GSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW 370 380 390 400 >>NP_057319 (OMIM: 605948) G-protein coupled receptor fa (403 aa) initn: 2696 init1: 2696 opt: 2696 Z-score: 3012.1 bits: 566.2 E(85289): 4.9e-161 Smith-Waterman score: 2696; 100.0% identity (100.0% similar) in 403 aa overlap (1-403:1-403) 10 20 30 40 50 60 pF1KSD MFVASERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MFVASERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD AVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 AVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDET 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD ICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 ICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD LVLTVLRDTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 LVLTVLRDTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD FLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 FLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD QENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 QENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPS 310 320 330 340 350 360 370 380 390 400 pF1KSD GSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW ::::::::::::::::::::::::::::::::::::::::::: NP_057 GSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW 370 380 390 400 >>XP_006721115 (OMIM: 605948) PREDICTED: G-protein coupl (403 aa) initn: 2696 init1: 2696 opt: 2696 Z-score: 3012.1 bits: 566.2 E(85289): 4.9e-161 Smith-Waterman score: 2696; 100.0% identity (100.0% similar) in 403 aa overlap (1-403:1-403) 10 20 30 40 50 60 pF1KSD MFVASERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MFVASERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KSD AVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDET 70 80 90 100 110 120 130 140 150 160 170 180 pF1KSD ICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KSD LVLTVLRDTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVLTVLRDTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KSD FLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KSD QENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPS 310 320 330 340 350 360 370 380 390 400 pF1KSD GSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW ::::::::::::::::::::::::::::::::::::::::::: XP_006 GSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW 370 380 390 400 >>NP_001291700 (OMIM: 605948) G-protein coupled receptor (534 aa) initn: 2696 init1: 2696 opt: 2696 Z-score: 3010.4 bits: 566.3 E(85289): 6.1e-161 Smith-Waterman score: 2696; 100.0% identity (100.0% similar) in 403 aa overlap (1-403:132-534) 10 20 30 pF1KSD MFVASERKMRAHQVLTFLLLFVITSVASEN :::::::::::::::::::::::::::::: NP_001 KLLLMNPPWSVAWGQEGFRAGTPGSRYLPRMFVASERKMRAHQVLTFLLLFVITSVASEN 110 120 130 140 150 160 40 50 60 70 80 90 pF1KSD ASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVRLPFIKEKEKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVRLPFIKEKEKK 170 180 190 200 210 220 100 110 120 130 140 150 pF1KSD SPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRL 230 240 250 260 270 280 160 170 180 190 200 210 pF1KSD VRHGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDTRPACAYEPMDFVMALIYDMVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRHGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDTRPACAYEPMDFVMALIYDMVL 290 300 310 320 330 340 220 230 240 250 260 270 pF1KSD LVVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDP 350 360 370 380 390 400 280 290 300 310 320 330 pF1KSD TLAITLAASGWVFVIFHAIPEIHCTLLPALQENTPNYFDTSQPRMRETAFEEDVQLPRAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLAITLAASGWVFVIFHAIPEIHCTLLPALQENTPNYFDTSQPRMRETAFEEDVQLPRAY 410 420 430 440 450 460 340 350 360 370 380 390 pF1KSD MENKAFSMDEHNAALRTAGFPNGSLGKRPSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MENKAFSMDEHNAALRTAGFPNGSLGKRPSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTI 470 480 490 500 510 520 400 pF1KSD PTAPPSHTGRHLW ::::::::::::: NP_001 PTAPPSHTGRHLW 530 >>XP_016875071 (OMIM: 607437) PREDICTED: G-protein coupl (345 aa) initn: 638 init1: 360 opt: 671 Z-score: 755.0 bits: 148.4 E(85289): 2.6e-35 Smith-Waterman score: 671; 35.2% identity (67.3% similar) in 324 aa overlap (35-351:3-317) 10 20 30 40 50 60 pF1KSD SERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAG . : .. .: ::: .. :::..:..: XP_016 MYKDC-IESTGDYFLLCDAEGPWGIILESLAI 10 20 30 70 80 90 100 110 120 pF1KSD AGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSV : ..:.::.: .: . :.. . . . ..::::..::::::.:::::. .. : XP_016 LGIVVTILLLLAFLFLMRKIQDCSQWNVLPTQLLFLLSVLGLFGLAFAFIIELNQQTAPV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KSD RRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLV-GLALCLMLVQVIIAVEWLVL : ::.::::::::::::..: . .::: : .: . .:. :.:.:::.:...: XP_016 RYFLFGVLFALCFSCLLAHASNLVKLVR-GCVSFSWTTILCIAIGCSLLQIIIATEYVTL 100 110 120 130 140 150 190 200 210 220 230 pF1KSD TVLR-----DTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLI . : . : : . .:::. :.: . :...:. .. :.:: . :: .: ...: XP_016 IMTRGMMFVNMTP-CQLN-VDFVVLLVYVLFLMALTFFVSKATFCGPCENWKQHGRLIFI 160 170 180 190 200 240 250 260 270 280 290 pF1KSD TAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLP :...:..:::.:..: : :: ..:. :.::.. :.:....:::.... .::. : : XP_016 TVLFSIIIWVVWISMLLRGNPQFQRQPQWDDPVVCIALVTNAWVFLLLYIVPEL-CILYR 210 220 230 240 250 260 300 310 320 330 340 350 pF1KSD ALQENTPNYFDTSQPRMRETAFE-EDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGK . ... : .. . .:. :. .: :: . : :...:: . : : XP_016 SCRQECPLQGNACPVTAYQHSFQVENQELSRARDSDGA----EEDVALTSYGTPIQPQTV 270 280 290 300 310 320 360 370 380 390 400 pF1KSD RPSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW XP_016 DPTQECFIPQAKLSPQQDAGGV 330 340 >>NP_061124 (OMIM: 607437) G-protein coupled receptor fa (345 aa) initn: 638 init1: 360 opt: 671 Z-score: 755.0 bits: 148.4 E(85289): 2.6e-35 Smith-Waterman score: 671; 35.2% identity (67.3% similar) in 324 aa overlap (35-351:3-317) 10 20 30 40 50 60 pF1KSD SERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAG . : .. .: ::: .. :::..:..: NP_061 MYKDC-IESTGDYFLLCDAEGPWGIILESLAI 10 20 30 70 80 90 100 110 120 pF1KSD AGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSV : ..:.::.: .: . :.. . . . ..::::..::::::.:::::. .. : NP_061 LGIVVTILLLLAFLFLMRKIQDCSQWNVLPTQLLFLLSVLGLFGLAFAFIIELNQQTAPV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KSD RRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLV-GLALCLMLVQVIIAVEWLVL : ::.::::::::::::..: . .::: : .: . .:. :.:.:::.:...: NP_061 RYFLFGVLFALCFSCLLAHASNLVKLVR-GCVSFSWTTILCIAIGCSLLQIIIATEYVTL 100 110 120 130 140 150 190 200 210 220 230 pF1KSD TVLR-----DTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLI . : . : : . .:::. :.: . :...:. .. :.:: . :: .: ...: NP_061 IMTRGMMFVNMTP-CQLN-VDFVVLLVYVLFLMALTFFVSKATFCGPCENWKQHGRLIFI 160 170 180 190 200 240 250 260 270 280 290 pF1KSD TAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLP :...:..:::.:..: : :: ..:. :.::.. :.:....:::.... .::. : : NP_061 TVLFSIIIWVVWISMLLRGNPQFQRQPQWDDPVVCIALVTNAWVFLLLYIVPEL-CILYR 210 220 230 240 250 260 300 310 320 330 340 350 pF1KSD ALQENTPNYFDTSQPRMRETAFE-EDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGK . ... : .. . .:. :. .: :: . : :...:: . : : NP_061 SCRQECPLQGNACPVTAYQHSFQVENQELSRARDSDGA----EEDVALTSYGTPIQPQTV 270 280 290 300 310 320 360 370 380 390 400 pF1KSD RPSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW NP_061 DPTQECFIPQAKLSPQQDAGGV 330 340 >>XP_005253478 (OMIM: 607437) PREDICTED: G-protein coupl (345 aa) initn: 638 init1: 360 opt: 671 Z-score: 755.0 bits: 148.4 E(85289): 2.6e-35 Smith-Waterman score: 671; 35.2% identity (67.3% similar) in 324 aa overlap (35-351:3-317) 10 20 30 40 50 60 pF1KSD SERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAG . : .. .: ::: .. :::..:..: XP_005 MYKDC-IESTGDYFLLCDAEGPWGIILESLAI 10 20 30 70 80 90 100 110 120 pF1KSD AGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSV : ..:.::.: .: . :.. . . . ..::::..::::::.:::::. .. : XP_005 LGIVVTILLLLAFLFLMRKIQDCSQWNVLPTQLLFLLSVLGLFGLAFAFIIELNQQTAPV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KSD RRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLV-GLALCLMLVQVIIAVEWLVL : ::.::::::::::::..: . .::: : .: . .:. :.:.:::.:...: XP_005 RYFLFGVLFALCFSCLLAHASNLVKLVR-GCVSFSWTTILCIAIGCSLLQIIIATEYVTL 100 110 120 130 140 150 190 200 210 220 230 pF1KSD TVLR-----DTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLI . : . : : . .:::. :.: . :...:. .. :.:: . :: .: ...: XP_005 IMTRGMMFVNMTP-CQLN-VDFVVLLVYVLFLMALTFFVSKATFCGPCENWKQHGRLIFI 160 170 180 190 200 240 250 260 270 280 290 pF1KSD TAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLP :...:..:::.:..: : :: ..:. :.::.. :.:....:::.... .::. : : XP_005 TVLFSIIIWVVWISMLLRGNPQFQRQPQWDDPVVCIALVTNAWVFLLLYIVPEL-CILYR 210 220 230 240 250 260 300 310 320 330 340 350 pF1KSD ALQENTPNYFDTSQPRMRETAFE-EDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGK . ... : .. . .:. :. .: :: . : :...:: . : : XP_005 SCRQECPLQGNACPVTAYQHSFQVENQELSRARDSDGA----EEDVALTSYGTPIQPQTV 270 280 290 300 310 320 360 370 380 390 400 pF1KSD RPSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW XP_005 DPTQECFIPQAKLSPQQDAGGV 330 340 >>XP_016875072 (OMIM: 607437) PREDICTED: G-protein coupl (300 aa) initn: 638 init1: 360 opt: 652 Z-score: 734.6 bits: 144.4 E(85289): 3.5e-34 Smith-Waterman score: 652; 35.5% identity (68.4% similar) in 301 aa overlap (35-328:3-298) 10 20 30 40 50 60 pF1KSD SERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAG . : .. .: ::: .. :::..:..: XP_016 MYKDC-IESTGDYFLLCDAEGPWGIILESLAI 10 20 30 70 80 90 100 110 120 pF1KSD AGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSV : ..:.::.: .: . :.. . . . ..::::..::::::.:::::. .. : XP_016 LGIVVTILLLLAFLFLMRKIQDCSQWNVLPTQLLFLLSVLGLFGLAFAFIIELNQQTAPV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KSD RRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLV-GLALCLMLVQVIIAVEWLVL : ::.::::::::::::..: . .::: : .: . .:. :.:.:::.:...: XP_016 RYFLFGVLFALCFSCLLAHASNLVKLVR-GCVSFSWTTILCIAIGCSLLQIIIATEYVTL 100 110 120 130 140 150 190 200 210 220 230 pF1KSD TVLR-----DTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLI . : . : : . .:::. :.: . :...:. .. :.:: . :: .: ...: XP_016 IMTRGMMFVNMTP-CQLN-VDFVVLLVYVLFLMALTFFVSKATFCGPCENWKQHGRLIFI 160 170 180 190 200 240 250 260 270 280 290 pF1KSD TAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLP :...:..:::.:..: : :: ..:. :.::.. :.:....:::.... .::. : : XP_016 TVLFSIIIWVVWISMLLRGNPQFQRQPQWDDPVVCIALVTNAWVFLLLYIVPEL-CILYR 210 220 230 240 250 260 300 310 320 330 340 350 pF1KSD ALQENTPNYFDTSQPRMRETAFE-EDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGK . ... : .. . .:. :. .: : XP_016 SCRQECPLQGNACPVTAYQHSFQVENQELSRDC 270 280 290 300 360 370 380 390 400 pF1KSD RPSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW >>NP_003970 (OMIM: 604138) retinoic acid-induced protein (357 aa) initn: 586 init1: 404 opt: 652 Z-score: 733.6 bits: 144.4 E(85289): 4e-34 Smith-Waterman score: 670; 37.4% identity (66.4% similar) in 321 aa overlap (36-349:8-313) 10 20 30 40 50 60 pF1KSD ERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGA :: : .: ::: ::::.:.:: : NP_003 MATTVPDGCRNGLKSKYYRLCDKAEAWGIVLETVATA 10 20 30 70 80 90 100 110 120 pF1KSD GALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVR :.. .. .:: : . . ........ . .::::::.::.::::::::: : . .: NP_003 GVVTSVAFMLTLPILVCKVQDSNRRKMLPTQFLFLLGVLGIFGLTFAFIIGLDGSTGPTR 40 50 60 70 80 90 130 140 150 160 170 180 pF1KSD RFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLV-GLALCLMLVQVIIAVEWLVLT ::.:.::..::::::..: . .::: : : . .. :::. . ::: .::.:..::: NP_003 FFLFGILFSICFSCLLAHAVSLTKLVR-GRKPLSLLVILGLAVGFSLVQDVIAIEYIVLT 100 110 120 130 140 150 190 200 210 220 230 pF1KSD VLRD-----TRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLIT . : .. . . :::. : : . :...:. .. ::.::.: :: .:: . .: NP_003 MNRTNVNVFSELSAPRRNEDFVLLLTYVLFLMALTFLMSSFTFCGSFTGWKRHGAHIYLT 160 170 180 190 200 210 240 250 260 270 280 290 pF1KSD AFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPA .::. :::::.:. .. . . :.: :. .:::.::::.. .. ::. : . NP_003 MLLSIAIWVAWITLLMLPDFDRR----WDDTILSSALAANGWVFLLAYVSPEF---WLLT 220 230 240 250 260 300 310 320 330 340 350 pF1KSD LQENTPNYFDTSQPRMRETAFEEDVQLPRAY-MENKAFSMDEHNAALRTAGFPNGSLGKR :.: .: : : :: . . ..: .::.:.:..: . ... .: NP_003 KQRNPMDY-----PV--EDAFCKPQLVKKSYGVENRAYSQEEITQGFEETGDTLYAPYST 270 280 290 300 310 320 360 370 380 390 400 pF1KSD PSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW NP_003 HFQLQNQPPQKEFSIPRAHAWPSPYKDYEVKKEGS 330 340 350 >>NP_061123 (OMIM: 605949) G-protein coupled receptor fa (453 aa) initn: 944 init1: 534 opt: 541 Z-score: 608.3 bits: 121.6 E(85289): 3.8e-27 Smith-Waterman score: 945; 40.5% identity (68.9% similar) in 395 aa overlap (8-384:12-390) 10 20 30 40 50 pF1KSD MFVASERKMRAHQVLTFLL---LFVITSVASENASTSRGCGLDLLPQYVSLCDLDA .: :..:.. : ::.. .. ... . ::. : : : .::: .. NP_061 MGTQPEPGLGARMAIHKALVMCLGLPLFLFPGAWAQG-HVPPGCSQGLNPLYYNLCDRSG 10 20 30 40 50 60 70 80 90 100 110 pF1KSD IWGIVVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAF ::::.::::::: . :..: .::.. :::... .:.: .: . .::::::::: :.:: NP_061 AWGIVLEAVAGAGIVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFAC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KSD IIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQ ... : . :. ::::.:::::.::::: .... . :.:.. :: :: . .:: : ::. NP_061 VVKPDFSTCASRRFLFGVLFAICFSCLAAHVFALNFLARKNHGPRGWVIFTVALLLTLVE 120 130 140 150 160 170 180 190 200 210 pF1KSD VIIAVEWLVLTVLRDTRPA---------------CAYEPMDFVMALIYDMVLLVVTLGLA ::: .:::..:..: . . :: ::::::::: :.::. .. : NP_061 VIINTEWLIITLVRGSGEGGPQGNSSAGWAVASPCAIANMDFVMALIYVMLLLLGAFLGA 180 190 200 210 220 230 220 230 240 250 260 270 pF1KSD LFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAA .:::..:::. .:.:.:.:. :: :::.:..:: .:: : ... .:.::::::.::: NP_061 WPALCGRYKRWRKHGVFVLLTTATSVAIWVVWIVMYTYGN-KQHNSPTWDDPTLAIALAA 240 250 260 270 280 290 280 290 300 310 320 330 pF1KSD SGWVFVIFHAIPEIHCTLLPALQENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSM ..:.::.:..:::. . . ... . . .. :: ..:. . ..::::::: NP_061 NAWAFVLFYVIPEVSQVTKSSPEQSYQGDMYPTRGVGYETILKEQ-KGQSMFVENKAFSM 300 310 320 330 340 350 340 350 360 370 380 390 pF1KSD DEHNAALRTAGFPNGSLGKRPSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHT :: :: : .. .: :. . ..::::::::.. NP_061 DEPVAAKRPVSPYSGYNGQ-------------LLTSVYQPTEMALMHKVPSEGAYDIILP 360 370 380 390 400 400 pF1KSD GRHLW NP_061 RATANSQVMGSANSTLRAEDMYSAQSHQAATPPKDGKNSQVFRNPYVWD 410 420 430 440 450 403 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 08:43:02 2016 done: Thu Nov 3 08:43:03 2016 Total Scan time: 8.610 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]