Result of FASTA (omim) for
pF1KSDF0018
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDF0018, 1386 aa
1>>>pF1KSDF0018 1386 - 1386 aa - 1386 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.7284+/-0.00039; mu= -5.1451+/- 0.024
mean_var=390.4479+/-79.702, 0's: 0 Z-trim(124.0): 319 B-trim: 881 in 1/57
Lambda= 0.064907
statistics sampled from 44340 (44708) to 44340 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.792), E-opt: 0.2 (0.524), width: 16
Scan time: 14.800
The best scores are: opt bits E(85289)
NP_073746 (OMIM: 611893,616763) pleckstrin homolog (1386) 9503 905.0 0
XP_005259220 (OMIM: 611893,616763) PREDICTED: plec (1386) 9503 905.0 0
XP_011525534 (OMIM: 611893,616763) PREDICTED: plec (1387) 9491 903.9 0
XP_006723397 (OMIM: 611893,616763) PREDICTED: plec (1327) 8839 842.9 0
XP_016882640 (OMIM: 611893,616763) PREDICTED: plec (1371) 6264 601.7 1.2e-170
XP_016882639 (OMIM: 611893,616763) PREDICTED: plec (1374) 6173 593.2 4.3e-168
XP_016875987 (OMIM: 609499) PREDICTED: guanine nuc (1087) 428 55.2 3.2e-06
XP_016875986 (OMIM: 609499) PREDICTED: guanine nuc (1096) 428 55.2 3.2e-06
NP_079255 (OMIM: 609499) guanine nucleotide exchan (1123) 428 55.2 3.3e-06
NP_001106203 (OMIM: 609499) guanine nucleotide exc (1125) 428 55.2 3.3e-06
NP_001307745 (OMIM: 609499) guanine nucleotide exc (1129) 428 55.2 3.3e-06
XP_016875984 (OMIM: 609499) PREDICTED: guanine nuc (1182) 428 55.2 3.4e-06
NP_001307746 (OMIM: 609499) guanine nucleotide exc ( 984) 412 53.6 8.3e-06
XP_016875988 (OMIM: 609499) PREDICTED: guanine nuc (1043) 412 53.7 8.7e-06
XP_016875985 (OMIM: 609499) PREDICTED: guanine nuc (1112) 412 53.7 9.1e-06
XP_011535793 (OMIM: 609499) PREDICTED: guanine nuc (1143) 412 53.7 9.3e-06
NP_001307744 (OMIM: 609499) guanine nucleotide exc (1148) 412 53.7 9.3e-06
XP_011535792 (OMIM: 609499) PREDICTED: guanine nuc (1152) 412 53.7 9.4e-06
XP_011535790 (OMIM: 609499) PREDICTED: guanine nuc (1163) 412 53.7 9.4e-06
XP_011535789 (OMIM: 609499) PREDICTED: guanine nuc (1179) 412 53.7 9.5e-06
XP_011535787 (OMIM: 609499) PREDICTED: guanine nuc (1181) 412 53.7 9.5e-06
XP_011535786 (OMIM: 609499) PREDICTED: guanine nuc (1185) 412 53.7 9.6e-06
XP_016875983 (OMIM: 609499) PREDICTED: guanine nuc (1187) 412 53.7 9.6e-06
XP_016875982 (OMIM: 609499) PREDICTED: guanine nuc (1207) 412 53.7 9.7e-06
XP_011535784 (OMIM: 609499) PREDICTED: guanine nuc (1211) 412 53.7 9.7e-06
XP_011535785 (OMIM: 609499) PREDICTED: guanine nuc (1211) 412 53.7 9.7e-06
XP_011535788 (OMIM: 609499) PREDICTED: guanine nuc (1238) 412 53.7 9.9e-06
NP_001273724 (OMIM: 613324) spermatogenesis-associ ( 574) 397 52.0 1.5e-05
NP_001273723 (OMIM: 613324) spermatogenesis-associ ( 596) 397 52.1 1.5e-05
NP_694568 (OMIM: 613324) spermatogenesis-associate ( 652) 397 52.1 1.6e-05
NP_001159743 (OMIM: 613324) spermatogenesis-associ (1277) 397 52.3 2.7e-05
NP_001273721 (OMIM: 613324) spermatogenesis-associ (1339) 397 52.3 2.8e-05
XP_005263746 (OMIM: 605216) PREDICTED: rho guanine ( 483) 384 50.8 3e-05
XP_005263745 (OMIM: 605216) PREDICTED: rho guanine ( 483) 384 50.8 3e-05
XP_011509578 (OMIM: 605216) PREDICTED: rho guanine ( 483) 384 50.8 3e-05
XP_011509579 (OMIM: 605216) PREDICTED: rho guanine ( 483) 384 50.8 3e-05
XP_005263744 (OMIM: 605216) PREDICTED: rho guanine ( 567) 384 50.8 3.4e-05
NP_127462 (OMIM: 605216) rho guanine nucleotide ex ( 670) 384 50.9 3.8e-05
NP_056135 (OMIM: 605216) rho guanine nucleotide ex ( 690) 384 50.9 3.9e-05
XP_011529194 (OMIM: 300429,300607) PREDICTED: rho ( 456) 370 49.4 7.1e-05
NP_001166950 (OMIM: 300429,300607) rho guanine nuc ( 463) 370 49.4 7.1e-05
XP_016884857 (OMIM: 300429,300607) PREDICTED: rho ( 495) 370 49.5 7.5e-05
XP_005262307 (OMIM: 300429,300607) PREDICTED: rho ( 495) 370 49.5 7.5e-05
XP_005262308 (OMIM: 300429,300607) PREDICTED: rho ( 495) 370 49.5 7.5e-05
XP_016884856 (OMIM: 300429,300607) PREDICTED: rho ( 495) 370 49.5 7.5e-05
NP_001317424 (OMIM: 300429,300607) rho guanine nuc ( 495) 370 49.5 7.5e-05
NP_056000 (OMIM: 300429,300607) rho guanine nucleo ( 516) 370 49.5 7.8e-05
XP_011529192 (OMIM: 300429,300607) PREDICTED: rho ( 516) 370 49.5 7.8e-05
XP_016884855 (OMIM: 300429,300607) PREDICTED: rho ( 516) 370 49.5 7.8e-05
XP_016884854 (OMIM: 300429,300607) PREDICTED: rho ( 516) 370 49.5 7.8e-05
>>NP_073746 (OMIM: 611893,616763) pleckstrin homology do (1386 aa)
initn: 9503 init1: 9503 opt: 9503 Z-score: 4824.0 bits: 905.0 E(85289): 0
Smith-Waterman score: 9503; 99.9% identity (99.9% similar) in 1386 aa overlap (1-1386:1-1386)
10 20 30 40 50 60
pF1KSD MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLSTVGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLSTVGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD EGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 EGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD LRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 LRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECFV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD QRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 QRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 LKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD GGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 GGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD FCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 FCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD KAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 KAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD QSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 QSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 SITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD GLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 GLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD DISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 DISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD LGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 LGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD RPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 RPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRASA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD NAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 NAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD AAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 AAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD PLHLQVPALTTFSDQGHPEIQVPATTPLPEHKSHMVIPAPSTAFCPEQGHCADIHVPTTP
:::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::
NP_073 PLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAFCPEQGHCADIHVPTTP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD ALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 ALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSW
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD HGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 HGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQV
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD PATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 PATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLEQ
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD KSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 KSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPH
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KSD SPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 SPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPP
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KSD PQPQPPPPAARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGAP
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_073 PQPQPPPPPARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGAP
1330 1340 1350 1360 1370 1380
pF1KSD DAPFHM
::::::
NP_073 DAPFHM
>>XP_005259220 (OMIM: 611893,616763) PREDICTED: pleckstr (1386 aa)
initn: 9503 init1: 9503 opt: 9503 Z-score: 4824.0 bits: 905.0 E(85289): 0
Smith-Waterman score: 9503; 99.9% identity (99.9% similar) in 1386 aa overlap (1-1386:1-1386)
10 20 30 40 50 60
pF1KSD MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLSTVGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLSTVGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD EGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD LRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECFV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD QRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD GGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD FCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD KAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD QSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD GLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD DISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD LGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD RPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRASA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD NAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD AAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD PLHLQVPALTTFSDQGHPEIQVPATTPLPEHKSHMVIPAPSTAFCPEQGHCADIHVPTTP
:::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::
XP_005 PLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAFCPEQGHCADIHVPTTP
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD ALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSW
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD HGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQV
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KSD PATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLEQ
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KSD KSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPH
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KSD SPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPP
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KSD PQPQPPPPAARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGAP
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PQPQPPPPPARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGAP
1330 1340 1350 1360 1370 1380
pF1KSD DAPFHM
::::::
XP_005 DAPFHM
>>XP_011525534 (OMIM: 611893,616763) PREDICTED: pleckstr (1387 aa)
initn: 9241 init1: 9241 opt: 9491 Z-score: 4817.9 bits: 903.9 E(85289): 0
Smith-Waterman score: 9491; 99.8% identity (99.9% similar) in 1387 aa overlap (1-1386:1-1387)
10 20 30 40 50
pF1KSD MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTA-PAAPTMASPRGSGSSTSLSTVG
::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_011 MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAAPAAPTMASPRGSGSSTSLSTVG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD SEGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD DLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD VQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQR
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD ILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRR
250 260 270 280 290 300
300 310 320 330 340 350
pF1KSD LGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGH
310 320 330 340 350 360
360 370 380 390 400 410
pF1KSD IFCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIP
370 380 390 400 410 420
420 430 440 450 460 470
pF1KSD AKAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGR
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD RQSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSG
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD TSITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEE
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD EGLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSL
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD SDISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPG
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD KLGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQL
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD ARPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRAS
790 800 810 820 830 840
840 850 860 870 880 890
pF1KSD ANAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWV
850 860 870 880 890 900
900 910 920 930 940 950
pF1KSD QAAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QAAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQE
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KSD GPLHLQVPALTTFSDQGHPEIQVPATTPLPEHKSHMVIPAPSTAFCPEQGHCADIHVPTT
::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::
XP_011 GPLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAFCPEQGHCADIHVPTT
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KSD PALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLS
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KSD WHGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WHGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQ
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KSD VPATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLE
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KSD QKSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPP
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KSD HSPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSP
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KSD PPQPQPPPPAARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGA
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPQPQPPPPPARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGA
1330 1340 1350 1360 1370 1380
1380
pF1KSD PDAPFHM
:::::::
XP_011 PDAPFHM
>>XP_006723397 (OMIM: 611893,616763) PREDICTED: pleckstr (1327 aa)
initn: 8829 init1: 8829 opt: 8839 Z-score: 4488.2 bits: 842.9 E(85289): 0
Smith-Waterman score: 8963; 95.6% identity (95.7% similar) in 1386 aa overlap (1-1386:1-1327)
10 20 30 40 50 60
pF1KSD MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLSTVGS
::::::::::::::::::::::::::::::::::::
XP_006 MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRT------------------------
10 20 30
70 80 90 100 110 120
pF1KSD EGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRD
:::::::::::::::::::::::::
XP_006 -----------------------------------GSARPSRLERVAREIVETERAYVRD
40 50 60
130 140 150 160 170 180
pF1KSD LRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECFV
70 80 90 100 110 120
190 200 210 220 230 240
pF1KSD QRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRI
130 140 150 160 170 180
250 260 270 280 290 300
pF1KSD LKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRL
190 200 210 220 230 240
310 320 330 340 350 360
pF1KSD GGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHI
250 260 270 280 290 300
370 380 390 400 410 420
pF1KSD FCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPA
310 320 330 340 350 360
430 440 450 460 470 480
pF1KSD KAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRR
370 380 390 400 410 420
490 500 510 520 530 540
pF1KSD QSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGT
430 440 450 460 470 480
550 560 570 580 590 600
pF1KSD SITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEE
490 500 510 520 530 540
610 620 630 640 650 660
pF1KSD GLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLS
550 560 570 580 590 600
670 680 690 700 710 720
pF1KSD DISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGK
610 620 630 640 650 660
730 740 750 760 770 780
pF1KSD LGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLA
670 680 690 700 710 720
790 800 810 820 830 840
pF1KSD RPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRASA
730 740 750 760 770 780
850 860 870 880 890 900
pF1KSD NAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQ
790 800 810 820 830 840
910 920 930 940 950 960
pF1KSD AAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEG
850 860 870 880 890 900
970 980 990 1000 1010 1020
pF1KSD PLHLQVPALTTFSDQGHPEIQVPATTPLPEHKSHMVIPAPSTAFCPEQGHCADIHVPTTP
:::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::
XP_006 PLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAFCPEQGHCADIHVPTTP
910 920 930 940 950 960
1030 1040 1050 1060 1070 1080
pF1KSD ALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSW
970 980 990 1000 1010 1020
1090 1100 1110 1120 1130 1140
pF1KSD HGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQV
1030 1040 1050 1060 1070 1080
1150 1160 1170 1180 1190 1200
pF1KSD PATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLEQ
1090 1100 1110 1120 1130 1140
1210 1220 1230 1240 1250 1260
pF1KSD KSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPH
1150 1160 1170 1180 1190 1200
1270 1280 1290 1300 1310 1320
pF1KSD SPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPP
1210 1220 1230 1240 1250 1260
1330 1340 1350 1360 1370 1380
pF1KSD PQPQPPPPAARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGAP
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQPQPPPPPARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGAP
1270 1280 1290 1300 1310 1320
pF1KSD DAPFHM
::::::
XP_006 DAPFHM
>>XP_016882640 (OMIM: 611893,616763) PREDICTED: pleckstr (1371 aa)
initn: 6510 init1: 6254 opt: 6264 Z-score: 3184.8 bits: 601.7 E(85289): 1.2e-170
Smith-Waterman score: 9338; 98.6% identity (98.7% similar) in 1387 aa overlap (1-1386:1-1371)
10 20 30 40 50
pF1KSD MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTA-PAAPTMASPRGSGSSTSLSTVG
::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_016 MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAAPAAPTMASPRGSGSSTSLSTVG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD SEGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD DLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD VQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQR
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD ILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRR
250 260 270 280 290 300
300 310 320 330 340 350
pF1KSD LGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGH
310 320 330 340 350 360
360 370 380 390 400 410
pF1KSD IFCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIP
370 380 390 400 410 420
420 430 440 450 460 470
pF1KSD AKAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGR
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNT-------------
430 440 450 460
480 490 500 510 520 530
pF1KSD RQSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ---EPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSG
470 480 490 500 510 520
540 550 560 570 580 590
pF1KSD TSITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEE
530 540 550 560 570 580
600 610 620 630 640 650
pF1KSD EGLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSL
590 600 610 620 630 640
660 670 680 690 700 710
pF1KSD SDISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPG
650 660 670 680 690 700
720 730 740 750 760 770
pF1KSD KLGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQL
710 720 730 740 750 760
780 790 800 810 820 830
pF1KSD ARPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRAS
770 780 790 800 810 820
840 850 860 870 880 890
pF1KSD ANAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWV
830 840 850 860 870 880
900 910 920 930 940 950
pF1KSD QAAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QAAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQE
890 900 910 920 930 940
960 970 980 990 1000 1010
pF1KSD GPLHLQVPALTTFSDQGHPEIQVPATTPLPEHKSHMVIPAPSTAFCPEQGHCADIHVPTT
::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::
XP_016 GPLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAFCPEQGHCADIHVPTT
950 960 970 980 990 1000
1020 1030 1040 1050 1060 1070
pF1KSD PALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLS
1010 1020 1030 1040 1050 1060
1080 1090 1100 1110 1120 1130
pF1KSD WHGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WHGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQ
1070 1080 1090 1100 1110 1120
1140 1150 1160 1170 1180 1190
pF1KSD VPATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLE
1130 1140 1150 1160 1170 1180
1200 1210 1220 1230 1240 1250
pF1KSD QKSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPP
1190 1200 1210 1220 1230 1240
1260 1270 1280 1290 1300 1310
pF1KSD HSPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSP
1250 1260 1270 1280 1290 1300
1320 1330 1340 1350 1360 1370
pF1KSD PPQPQPPPPAARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGA
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPQPQPPPPPARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGA
1310 1320 1330 1340 1350 1360
1380
pF1KSD PDAPFHM
:::::::
XP_016 PDAPFHM
1370
>>XP_016882639 (OMIM: 611893,616763) PREDICTED: pleckstr (1374 aa)
initn: 6397 init1: 6141 opt: 6173 Z-score: 3138.8 bits: 593.2 E(85289): 4.3e-168
Smith-Waterman score: 9358; 98.8% identity (98.9% similar) in 1387 aa overlap (1-1386:1-1374)
10 20 30 40 50
pF1KSD MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTA-PAAPTMASPRGSGSSTSLSTVG
::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_016 MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAAPAAPTMASPRGSGSSTSLSTVG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD SEGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD DLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD VQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQR
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD ILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRR
250 260 270 280 290 300
300 310 320 330 340 350
pF1KSD LGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGH
310 320 330 340 350 360
360 370 380 390 400 410
pF1KSD IFCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIP
370 380 390 400 410 420
420 430 440 450 460 470
pF1KSD AKAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGR
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD RQSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSG
::: ::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQS-------------AKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSG
490 500 510 520
540 550 560 570 580 590
pF1KSD TSITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEE
530 540 550 560 570 580
600 610 620 630 640 650
pF1KSD EGLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSL
590 600 610 620 630 640
660 670 680 690 700 710
pF1KSD SDISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPG
650 660 670 680 690 700
720 730 740 750 760 770
pF1KSD KLGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQL
710 720 730 740 750 760
780 790 800 810 820 830
pF1KSD ARPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRAS
770 780 790 800 810 820
840 850 860 870 880 890
pF1KSD ANAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWV
830 840 850 860 870 880
900 910 920 930 940 950
pF1KSD QAAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QAAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQE
890 900 910 920 930 940
960 970 980 990 1000 1010
pF1KSD GPLHLQVPALTTFSDQGHPEIQVPATTPLPEHKSHMVIPAPSTAFCPEQGHCADIHVPTT
::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::
XP_016 GPLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAFCPEQGHCADIHVPTT
950 960 970 980 990 1000
1020 1030 1040 1050 1060 1070
pF1KSD PALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLS
1010 1020 1030 1040 1050 1060
1080 1090 1100 1110 1120 1130
pF1KSD WHGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WHGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQ
1070 1080 1090 1100 1110 1120
1140 1150 1160 1170 1180 1190
pF1KSD VPATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLE
1130 1140 1150 1160 1170 1180
1200 1210 1220 1230 1240 1250
pF1KSD QKSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPP
1190 1200 1210 1220 1230 1240
1260 1270 1280 1290 1300 1310
pF1KSD HSPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSP
1250 1260 1270 1280 1290 1300
1320 1330 1340 1350 1360 1370
pF1KSD PPQPQPPPPAARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGA
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPQPQPPPPPARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGA
1310 1320 1330 1340 1350 1360
1380
pF1KSD PDAPFHM
:::::::
XP_016 PDAPFHM
1370
>>XP_016875987 (OMIM: 609499) PREDICTED: guanine nucleot (1087 aa)
initn: 277 init1: 143 opt: 428 Z-score: 232.7 bits: 55.2 E(85289): 3.2e-06
Smith-Waterman score: 464; 27.4% identity (52.2% similar) in 632 aa overlap (35-617:493-1087)
10 20 30 40 50 60
pF1KSD AQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLST---VGSE
.: :. :. :.. ..: : :::
XP_016 EHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGSE
470 480 490 500 510 520
70 80 90 100 110
pF1KSD GDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSR-----LER-VAREIVETER
.. . : .: : : .. : : ::: . :.: : :...:::
XP_016 NSSSEG-----GALRRGPYRRAKSEMSESRQG-RGSAGEEEESLAILRRHVMSELLDTER
530 540 550 560 570
120 130 140 150 160
pF1KSD AYVRDLRSIVEDYLG----PLLDGGV-LGLSVEQVGTLFANIEDIYEFSSEL-LEDLENS
:::..: ..: : . ::. . :: .. .::.:.:.::.: ... :..:::
XP_016 AYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKK-DVLFGNMEEIYHFHNRIFLRELENY
580 590 600 610 620 630
170 180 190 200 210 220
pF1KSD SSAGG-IAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLP
.. ...::..: :::.:: ::.: : : .: :. : : ..:: : .: :.:
XP_016 TDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCP----FFQECQRKLDHKLS
640 650 660 670 680 690
230 240 250 260 270 280
pF1KSD LQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQE
:.:.:::::::: ::.:::.:. :. . . : : ..::. :. .. .:: .
XP_016 LDSYLLKPVQRITKYQLLLKEMLKY---SRNCEGAEDLQEALSSILGILKAVND----SM
700 710 720 730 740
290 300 310 320 330
pF1KSD HAARLQEVQRRLGGWTGPELSAFGELVLEGAF-------RGGGGGGP--RLRGGERLLFL
: . :. : .:. .:.:...:.: :: :.. .: :::
XP_016 HLIAIT-------GYDG-NLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFL
750 760 770 780 790
340 350 360 370 380
pF1KSD FSRMLLVAKRR-----GLE----YTYKGHIFCCNLSVSESPR-DPLGFKVSDLTIPKHRH
. .: :.: : : :.:: . ....:. . : :.. . .. .
XP_016 HEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIW-YNAREEVY
800 810 820 830 840 850
390 400 410 420 430 440
pF1KSD LLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPVLEPLTPPLG
..:: . : : :.. ..... . : :. ...: :.: . : :. .: :
XP_016 IVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRAL-EQS-QSLPLPAPT--STSPSRG
860 870 880 890 900 910
450 460 470 480 490
pF1KSD SPR---PRDARSFTP----GRRNTAPSPGPSVIRRGRRQS----EPVKDPYVMFPQNAKP
. : . :. : : ..:: : .: .. : .: . .
XP_016 NSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQI
920 930 940 950 960 970
500 510 520 530 540 550
pF1KSD GFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSITEEILELLNQRGL---
. . : .: : : . : . . : : .:: .: . ...: . : ...::
XP_016 NSSDAEEDGGLGPKKLVP--GKYTVVADHEKGGPDALRVRSGDVVELVQE--GDEGLWYV
980 990 1000 1010 1020
560 570 580 590 600 610
pF1KSD RDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEEGLEMDERGPSPLHVL
:: :.: :..: . . . : : : .:: .. .: : .:. :
XP_016 RD--PTTGKEGWVPASSLSVRLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGGQAPFSDL
1030 1040 1050 1060 1070 1080
620 630 640 650 660 670
pF1KSD EGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLSDISDVFEMPCLPAIP
.:
XP_016 QG
>>XP_016875986 (OMIM: 609499) PREDICTED: guanine nucleot (1096 aa)
initn: 277 init1: 143 opt: 428 Z-score: 232.7 bits: 55.2 E(85289): 3.2e-06
Smith-Waterman score: 464; 27.4% identity (52.2% similar) in 632 aa overlap (35-617:502-1096)
10 20 30 40 50 60
pF1KSD AQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLST---VGSE
.: :. :. :.. ..: : :::
XP_016 EHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGSE
480 490 500 510 520 530
70 80 90 100 110
pF1KSD GDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSR-----LER-VAREIVETER
.. . : .: : : .. : : ::: . :.: : :...:::
XP_016 NSSSEG-----GALRRGPYRRAKSEMSESRQG-RGSAGEEEESLAILRRHVMSELLDTER
540 550 560 570 580
120 130 140 150 160
pF1KSD AYVRDLRSIVEDYLG----PLLDGGV-LGLSVEQVGTLFANIEDIYEFSSEL-LEDLENS
:::..: ..: : . ::. . :: .. .::.:.:.::.: ... :..:::
XP_016 AYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKK-DVLFGNMEEIYHFHNRIFLRELENY
590 600 610 620 630 640
170 180 190 200 210 220
pF1KSD SSAGG-IAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLP
.. ...::..: :::.:: ::.: : : .: :. : : ..:: : .: :.:
XP_016 TDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCP----FFQECQRKLDHKLS
650 660 670 680 690 700
230 240 250 260 270 280
pF1KSD LQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQE
:.:.:::::::: ::.:::.:. :. . . : : ..::. :. .. .:: .
XP_016 LDSYLLKPVQRITKYQLLLKEMLKY---SRNCEGAEDLQEALSSILGILKAVND----SM
710 720 730 740 750
290 300 310 320 330
pF1KSD HAARLQEVQRRLGGWTGPELSAFGELVLEGAF-------RGGGGGGP--RLRGGERLLFL
: . :. : .:. .:.:...:.: :: :.. .: :::
XP_016 HLIAIT-------GYDG-NLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFL
760 770 780 790 800
340 350 360 370 380
pF1KSD FSRMLLVAKRR-----GLE----YTYKGHIFCCNLSVSESPR-DPLGFKVSDLTIPKHRH
. .: :.: : : :.:: . ....:. . : :.. . .. .
XP_016 HEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIW-YNAREEVY
810 820 830 840 850 860
390 400 410 420 430 440
pF1KSD LLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPVLEPLTPPLG
..:: . : : :.. ..... . : :. ...: :.: . : :. .: :
XP_016 IVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRAL-EQS-QSLPLPAPT--STSPSRG
870 880 890 900 910 920
450 460 470 480 490
pF1KSD SPR---PRDARSFTP----GRRNTAPSPGPSVIRRGRRQS----EPVKDPYVMFPQNAKP
. : . :. : : ..:: : .: .. : .: . .
XP_016 NSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQI
930 940 950 960 970 980
500 510 520 530 540 550
pF1KSD GFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSITEEILELLNQRGL---
. . : .: : : . : . . : : .:: .: . ...: . : ...::
XP_016 NSSDAEEDGGLGPKKLVP--GKYTVVADHEKGGPDALRVRSGDVVELVQE--GDEGLWYV
990 1000 1010 1020 1030
560 570 580 590 600 610
pF1KSD RDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEEGLEMDERGPSPLHVL
:: :.: :..: . . . : : : .:: .. .: : .:. :
XP_016 RD--PTTGKEGWVPASSLSVRLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGGQAPFSDL
1040 1050 1060 1070 1080 1090
620 630 640 650 660 670
pF1KSD EGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLSDISDVFEMPCLPAIP
.:
XP_016 QG
>>NP_079255 (OMIM: 609499) guanine nucleotide exchange f (1123 aa)
initn: 277 init1: 143 opt: 428 Z-score: 232.6 bits: 55.2 E(85289): 3.3e-06
Smith-Waterman score: 464; 27.4% identity (52.2% similar) in 632 aa overlap (35-617:529-1123)
10 20 30 40 50 60
pF1KSD AQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLST---VGSE
.: :. :. :.. ..: : :::
NP_079 EHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGSE
500 510 520 530 540 550
70 80 90 100 110
pF1KSD GDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSR-----LER-VAREIVETER
.. . : .: : : .. : : ::: . :.: : :...:::
NP_079 NSSSEG-----GALRRGPYRRAKSEMSESRQG-RGSAGEEEESLAILRRHVMSELLDTER
560 570 580 590 600 610
120 130 140 150 160
pF1KSD AYVRDLRSIVEDYLG----PLLDGGV-LGLSVEQVGTLFANIEDIYEFSSEL-LEDLENS
:::..: ..: : . ::. . :: .. .::.:.:.::.: ... :..:::
NP_079 AYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKK-DVLFGNMEEIYHFHNRIFLRELENY
620 630 640 650 660 670
170 180 190 200 210 220
pF1KSD SSAGG-IAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLP
.. ...::..: :::.:: ::.: : : .: :. : : ..:: : .: :.:
NP_079 TDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCP----FFQECQRKLDHKLS
680 690 700 710 720
230 240 250 260 270 280
pF1KSD LQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQE
:.:.:::::::: ::.:::.:. :. . . : : ..::. :. .. .:: .
NP_079 LDSYLLKPVQRITKYQLLLKEMLKY---SRNCEGAEDLQEALSSILGILKAVND----SM
730 740 750 760 770 780
290 300 310 320 330
pF1KSD HAARLQEVQRRLGGWTGPELSAFGELVLEGAF-------RGGGGGGP--RLRGGERLLFL
: . :. : .:. .:.:...:.: :: :.. .: :::
NP_079 HLIAIT-------GYDG-NLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFL
790 800 810 820 830
340 350 360 370 380
pF1KSD FSRMLLVAKRR-----GLE----YTYKGHIFCCNLSVSESPR-DPLGFKVSDLTIPKHRH
. .: :.: : : :.:: . ....:. . : :.. . .. .
NP_079 HEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIW-YNAREEVY
840 850 860 870 880 890
390 400 410 420 430 440
pF1KSD LLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPVLEPLTPPLG
..:: . : : :.. ..... . : :. ...: :.: . : :. .: :
NP_079 IVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRAL-EQS-QSLPLPAPT--STSPSRG
900 910 920 930 940
450 460 470 480 490
pF1KSD SPR---PRDARSFTP----GRRNTAPSPGPSVIRRGRRQS----EPVKDPYVMFPQNAKP
. : . :. : : ..:: : .: .. : .: . .
NP_079 NSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQI
950 960 970 980 990 1000
500 510 520 530 540 550
pF1KSD GFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSITEEILELLNQRGL---
. . : .: : : . : . . : : .:: .: . ...: . : ...::
NP_079 NSSDAEEDGGLGPKKLVP--GKYTVVADHEKGGPDALRVRSGDVVELVQE--GDEGLWYV
1010 1020 1030 1040 1050 1060
560 570 580 590 600 610
pF1KSD RDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEEGLEMDERGPSPLHVL
:: :.: :..: . . . : : : .:: .. .: : .:. :
NP_079 RD--PTTGKEGWVPASSLSVRLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGGQAPFSDL
1070 1080 1090 1100 1110 1120
620 630 640 650 660 670
pF1KSD EGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLSDISDVFEMPCLPAIP
.:
NP_079 QG
>>NP_001106203 (OMIM: 609499) guanine nucleotide exchang (1125 aa)
initn: 277 init1: 143 opt: 428 Z-score: 232.5 bits: 55.2 E(85289): 3.3e-06
Smith-Waterman score: 464; 27.4% identity (52.2% similar) in 632 aa overlap (35-617:531-1125)
10 20 30 40 50 60
pF1KSD AQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLST---VGSE
.: :. :. :.. ..: : :::
NP_001 EHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGSE
510 520 530 540 550 560
70 80 90 100 110
pF1KSD GDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSR-----LER-VAREIVETER
.. . : .: : : .. : : ::: . :.: : :...:::
NP_001 NSSSEG-----GALRRGPYRRAKSEMSESRQG-RGSAGEEEESLAILRRHVMSELLDTER
570 580 590 600 610
120 130 140 150 160
pF1KSD AYVRDLRSIVEDYLG----PLLDGGV-LGLSVEQVGTLFANIEDIYEFSSEL-LEDLENS
:::..: ..: : . ::. . :: .. .::.:.:.::.: ... :..:::
NP_001 AYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKK-DVLFGNMEEIYHFHNRIFLRELENY
620 630 640 650 660 670
170 180 190 200 210 220
pF1KSD SSAGG-IAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLP
.. ...::..: :::.:: ::.: : : .: :. : : ..:: : .: :.:
NP_001 TDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCP----FFQECQRKLDHKLS
680 690 700 710 720
230 240 250 260 270 280
pF1KSD LQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQE
:.:.:::::::: ::.:::.:. :. . . : : ..::. :. .. .:: .
NP_001 LDSYLLKPVQRITKYQLLLKEMLKY---SRNCEGAEDLQEALSSILGILKAVND----SM
730 740 750 760 770 780
290 300 310 320 330
pF1KSD HAARLQEVQRRLGGWTGPELSAFGELVLEGAF-------RGGGGGGP--RLRGGERLLFL
: . :. : .:. .:.:...:.: :: :.. .: :::
NP_001 HLIAIT-------GYDG-NLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFL
790 800 810 820 830
340 350 360 370 380
pF1KSD FSRMLLVAKRR-----GLE----YTYKGHIFCCNLSVSESPR-DPLGFKVSDLTIPKHRH
. .: :.: : : :.:: . ....:. . : :.. . .. .
NP_001 HEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIW-YNAREEVY
840 850 860 870 880 890
390 400 410 420 430 440
pF1KSD LLQAKNQEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKPVLEPLTPPLG
..:: . : : :.. ..... . : :. ...: :.: . : :. .: :
NP_001 IVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRAL-EQS-QSLPLPAPT--STSPSRG
900 910 920 930 940
450 460 470 480 490
pF1KSD SPR---PRDARSFTP----GRRNTAPSPGPSVIRRGRRQS----EPVKDPYVMFPQNAKP
. : . :. : : ..:: : .: .. : .: . .
NP_001 NSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQI
950 960 970 980 990 1000
500 510 520 530 540 550
pF1KSD GFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGTSITEEILELLNQRGL---
. . : .: : : . : . . : : .:: .: . ...: . : ...::
NP_001 NSSDAEEDGGLGPKKLVP--GKYTVVADHEKGGPDALRVRSGDVVELVQE--GDEGLWYV
1010 1020 1030 1040 1050 1060
560 570 580 590 600 610
pF1KSD RDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEEGLEMDERGPSPLHVL
:: :.: :..: . . . : : : .:: .. .: : .:. :
NP_001 RD--PTTGKEGWVPASSLSVRLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGGQAPFSDL
1070 1080 1090 1100 1110 1120
620 630 640 650 660 670
pF1KSD EGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLSDISDVFEMPCLPAIP
.:
NP_001 QG
1386 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 08:48:59 2016 done: Thu Nov 3 08:49:02 2016
Total Scan time: 14.800 Total Display time: 0.430
Function used was FASTA [36.3.4 Apr, 2011]