Result of FASTA (omim) for
pF1KSDF0070
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDF0070, 1302 aa
1>>>pF1KSDF0070 1302 - 1302 aa - 1302 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.7114+/-0.000396; mu= -1.3439+/- 0.025
mean_var=322.8363+/-66.077, 0's: 0 Z-trim(122.8): 425 B-trim: 160 in 1/57
Lambda= 0.071381
statistics sampled from 41049 (41521) to 41049 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.776), E-opt: 0.2 (0.487), width: 16
Scan time: 17.250
The best scores are: opt bits E(85289)
NP_001123616 (OMIM: 601216,602090,613097) latent-t (1303) 9814 1025.4 0
XP_011543334 (OMIM: 601216,602090,613097) PREDICTE (1312) 8375 877.3 0
NP_066548 (OMIM: 601216,602090,613097) latent-tran (1256) 8124 851.4 0
NP_001157738 (OMIM: 601216,602090,613097) latent-t (1139) 7339 770.5 0
XP_011543335 (OMIM: 601216,602090,613097) PREDICTE (1265) 6685 703.2 2.9e-201
XP_016873226 (OMIM: 601216,602090,613097) PREDICTE ( 828) 4377 465.4 7.4e-130
NP_001159738 (OMIM: 150390) latent-transforming gr (1300) 2081 229.1 1.6e-58
XP_005264375 (OMIM: 150390) PREDICTED: latent-tran (1626) 2080 229.1 2e-58
XP_011525681 (OMIM: 604710,613177) PREDICTED: late (1595) 2048 225.8 1.9e-57
XP_011525678 (OMIM: 604710,613177) PREDICTED: late (1662) 2048 225.8 2e-57
NP_001159737 (OMIM: 150390) latent-transforming gr (1342) 1978 218.5 2.5e-55
XP_005264374 (OMIM: 150390) PREDICTED: latent-tran (1668) 1978 218.6 3e-55
XP_011531163 (OMIM: 150390) PREDICTED: latent-tran (1632) 1816 201.9 3.1e-50
XP_011531161 (OMIM: 150390) PREDICTED: latent-tran (1669) 1746 194.7 4.6e-48
XP_011531160 (OMIM: 150390) PREDICTED: latent-tran (1680) 1695 189.4 1.8e-46
XP_011525680 (OMIM: 604710,613177) PREDICTED: late (1611) 1551 174.6 5e-42
XP_011525685 (OMIM: 604710,613177) PREDICTED: late (1522) 1524 171.8 3.3e-41
XP_011525687 (OMIM: 604710,613177) PREDICTED: late (1478) 1488 168.1 4.2e-40
XP_011525686 (OMIM: 604710,613177) PREDICTED: late (1480) 1482 167.5 6.4e-40
XP_011525688 (OMIM: 604710,613177) PREDICTED: late (1436) 1468 166.0 1.7e-39
XP_011525689 (OMIM: 604710,613177) PREDICTED: late (1421) 1457 164.9 3.7e-39
NP_001036010 (OMIM: 604710,613177) latent-transfor (1557) 1457 164.9 4e-39
NP_003564 (OMIM: 604710,613177) latent-transformin (1587) 1457 164.9 4e-39
NP_001036009 (OMIM: 604710,613177) latent-transfor (1624) 1457 164.9 4.1e-39
XP_011525679 (OMIM: 604710,613177) PREDICTED: late (1635) 1457 164.9 4.1e-39
XP_016882841 (OMIM: 604710,613177) PREDICTED: late (1591) 1435 162.6 1.9e-38
XP_011525683 (OMIM: 604710,613177) PREDICTED: late (1593) 1429 162.0 3e-38
XP_016882842 (OMIM: 604710,613177) PREDICTED: late (1549) 1407 159.7 1.4e-37
XP_011531158 (OMIM: 150390) PREDICTED: latent-tran (1682) 1295 148.2 4.4e-34
XP_016859597 (OMIM: 150390) PREDICTED: latent-tran (1681) 1286 147.3 8.4e-34
XP_016882843 (OMIM: 604710,613177) PREDICTED: late (1438) 1281 146.7 1.1e-33
XP_011525682 (OMIM: 604710,613177) PREDICTED: late (1593) 1256 144.2 6.9e-33
NP_001159736 (OMIM: 150390) latent-transforming gr (1353) 1236 142.1 2.5e-32
XP_016859599 (OMIM: 150390) PREDICTED: latent-tran (1639) 1238 142.4 2.5e-32
XP_016859598 (OMIM: 150390) PREDICTED: latent-tran (1679) 1235 142.1 3.2e-32
XP_011531159 (OMIM: 150390) PREDICTED: latent-tran (1680) 1235 142.1 3.2e-32
XP_011525684 (OMIM: 604710,613177) PREDICTED: late (1554) 1167 135.0 3.9e-30
NP_000618 (OMIM: 150390) latent-transforming growt (1395) 1133 131.5 4e-29
XP_011531162 (OMIM: 150390) PREDICTED: latent-tran (1666) 1133 131.6 4.6e-29
XP_011531157 (OMIM: 150390) PREDICTED: latent-tran (1720) 1133 131.6 4.7e-29
NP_996826 (OMIM: 150390) latent-transforming growt (1721) 1133 131.6 4.7e-29
XP_011531155 (OMIM: 150390) PREDICTED: latent-tran (1722) 1133 131.6 4.8e-29
XP_011531164 (OMIM: 150390) PREDICTED: latent-tran (1248) 1093 127.3 6.5e-28
XP_016882866 (OMIM: 608529) PREDICTED: fibrillin-3 (1948) 1054 123.5 1.5e-26
XP_016864717 (OMIM: 121050,612570,616118) PREDICTE (2861) 1049 123.1 2.8e-26
NP_001990 (OMIM: 121050,612570,616118) fibrillin-2 (2912) 1049 123.1 2.9e-26
XP_011535067 (OMIM: 251750,600975,602091,613086,61 (1694) 1036 121.6 4.8e-26
NP_000419 (OMIM: 251750,600975,602091,613086,61481 (1821) 1036 121.6 5e-26
XP_016882867 (OMIM: 608529) PREDICTED: fibrillin-3 (1595) 990 116.8 1.2e-24
XP_016882863 (OMIM: 608529) PREDICTED: fibrillin-3 (2777) 969 114.8 8.3e-24
>>NP_001123616 (OMIM: 601216,602090,613097) latent-trans (1303 aa)
initn: 9658 init1: 9658 opt: 9814 Z-score: 5475.6 bits: 1025.4 E(85289): 0
Smith-Waterman score: 9814; 99.9% identity (99.9% similar) in 1303 aa overlap (1-1302:1-1303)
10 20 30 40 50
pF1KSD MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLL-GLGGRVEGGPAGERGAGGGGALARE
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
NP_001 MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ
250 260 270 280 290 300
300 310 320 330 340 350
pF1KSD EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA
310 320 330 340 350 360
360 370 380 390 400 410
pF1KSD MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT
370 380 390 400 410 420
420 430 440 450 460 470
pF1KSD TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD
790 800 810 820 830 840
840 850 860 870 880 890
pF1KSD CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP
850 860 870 880 890 900
900 910 920 930 940 950
pF1KSD TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KSD VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KSD CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KSD MDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWS
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KSD QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KSD PLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300
pF1KSD LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
:::::::::::::::::::::::::::::::::::::::::::
NP_001 LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
1270 1280 1290 1300
>>XP_011543334 (OMIM: 601216,602090,613097) PREDICTED: l (1312 aa)
initn: 8501 init1: 8293 opt: 8375 Z-score: 4674.7 bits: 877.3 E(85289): 0
Smith-Waterman score: 9786; 99.2% identity (99.2% similar) in 1312 aa overlap (1-1302:1-1312)
10 20 30 40 50
pF1KSD MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLL-GLGGRVEGGPAGERGAGGGGALARE
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
XP_011 MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAE---------VQAPPPVVNVR
:::::::::::::::::::::::::::::::::::::::: :::::::::::
XP_011 SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEALRPPRPPPVQAPPPVVNVR
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD VHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGS
250 260 270 280 290 300
300 310 320 330 340 350
pF1KSD NPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNST
310 320 330 340 350 360
360 370 380 390 400 410
pF1KSD HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSP
370 380 390 400 410 420
420 430 440 450 460 470
pF1KSD EHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLT
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD IQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTA
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD TTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECV
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD PGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHV
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD GAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPS
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD SCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCA
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD QGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD
790 800 810 820 830 840
840 850 860 870 880 890
pF1KSD FPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYV
850 860 870 880 890 900
900 910 920 930 940 950
pF1KSD CVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWG
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KSD DHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCV
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KSD NTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPA
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KSD QRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERA
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KSD PERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQS
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KSD ESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRAR
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300
pF1KSD CVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
1270 1280 1290 1300 1310
>>NP_066548 (OMIM: 601216,602090,613097) latent-transfor (1256 aa)
initn: 7935 init1: 7935 opt: 8124 Z-score: 4535.3 bits: 851.4 E(85289): 0
Smith-Waterman score: 9326; 96.3% identity (96.3% similar) in 1303 aa overlap (1-1302:1-1256)
10 20 30 40 50
pF1KSD MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLL-GLGGRVEGGPAGERGAGGGGALARE
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
NP_066 MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 QVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQ
250 260 270 280 290 300
300 310 320 330 340 350
pF1KSD EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 EDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECA
310 320 330 340 350 360
360 370 380 390 400 410
pF1KSD MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 MPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLT
370 380 390 400 410 420
420 430 440 450 460 470
pF1KSD TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 TRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSL
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 FLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYP
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 CNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVD
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 LNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCEN
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 KPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGD
790 800 810 820 830 840
840 850 860 870 880 890
pF1KSD CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 CINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTP
850 860 870 880 890 900
900 910 920 930 940 950
pF1KSD TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 TQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCP
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KSD VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 VYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KSD CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 CKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEE
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KSD MDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWS
: ::::::::::::
NP_066 M-----------------------------------------------ERAPERRDVCWS
1090
1140 1150 1160 1170 1180 1190
pF1KSD QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS
1100 1110 1120 1130 1140 1150
1200 1210 1220 1230 1240 1250
pF1KSD PLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 PLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRE
1160 1170 1180 1190 1200 1210
1260 1270 1280 1290 1300
pF1KSD LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
:::::::::::::::::::::::::::::::::::::::::::
NP_066 LNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
1220 1230 1240 1250
>>NP_001157738 (OMIM: 601216,602090,613097) latent-trans (1139 aa)
initn: 7306 init1: 7306 opt: 7339 Z-score: 4099.0 bits: 770.5 E(85289): 0
Smith-Waterman score: 8541; 96.0% identity (96.0% similar) in 1186 aa overlap (117-1302:1-1139)
90 100 110 120 130 140
pF1KSD SNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGA
::::::::::::::::::::::::::::::
NP_001 MNGGQCSSRNQCLCPPDFTGRFCQVPAGGA
10 20 30
150 160 170 180 190 200
pF1KSD GGGTGGSGPGLSRTGALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGTGGSGPGLSRTGALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAA
40 50 60 70 80 90
210 220 230 240 250 260
pF1KSD FLVPLGPGQISAEVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLVPLGPGQISAEVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSH
100 110 120 130 140 150
270 280 290 300 310 320
pF1KSD PRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGV
160 170 180 190 200 210
330 340 350 360 370 380
pF1KSD QKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSL
220 230 240 250 260 270
390 400 410 420 430 440
pF1KSD GPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDG
280 290 300 310 320 330
450 460 470 480 490 500
pF1KSD TAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTE
340 350 360 370 380 390
510 520 530 540 550 560
pF1KSD EERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEI
400 410 420 430 440 450
570 580 590 600 610 620
pF1KSD APTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGP
460 470 480 490 500 510
630 640 650 660 670 680
pF1KSD GRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNC
520 530 540 550 560 570
690 700 710 720 730 740
pF1KSD YPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNE
580 590 600 610 620 630
750 760 770 780 790 800
pF1KSD CAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSF
640 650 660 670 680 690
810 820 830 840 850 860
pF1KSD QCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDI
700 710 720 730 740 750
870 880 890 900 910 920
pF1KSD DECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTV
760 770 780 790 800 810
930 940 950 960 970 980
pF1KSD FCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYG
820 830 840 850 860 870
990 1000 1010 1020 1030 1040
pF1KSD IPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCR
880 890 900 910 920 930
1050 1060 1070 1080 1090 1100
pF1KSD NGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCE
::::::::::::::::::::::::::::::::::
NP_001 NGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEM--------------------------
940 950 960
1110 1120 1130 1140 1150 1160
pF1KSD CRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQG
:::::::::::::::::::::::::::::::::::::::
NP_001 ---------------------ERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQG
970 980 990 1000
1170 1180 1190 1200 1210 1220
pF1KSD RGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGR
1010 1020 1030 1040 1050 1060
1230 1240 1250 1260 1270 1280
pF1KSD CVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAG
1070 1080 1090 1100 1110 1120
1290 1300
pF1KSD FARSRPHGACVPQRRR
::::::::::::::::
NP_001 FARSRPHGACVPQRRR
1130
>>XP_011543335 (OMIM: 601216,602090,613097) PREDICTED: l (1265 aa)
initn: 6778 init1: 6570 opt: 6685 Z-score: 3734.4 bits: 703.2 E(85289): 2.9e-201
Smith-Waterman score: 9298; 95.7% identity (95.7% similar) in 1312 aa overlap (1-1302:1-1265)
10 20 30 40 50
pF1KSD MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLL-GLGGRVEGGPAGERGAGGGGALARE
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
XP_011 MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAE---------VQAPPPVVNVR
:::::::::::::::::::::::::::::::::::::::: :::::::::::
XP_011 SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEALRPPRPPPVQAPPPVVNVR
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD VHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGS
250 260 270 280 290 300
300 310 320 330 340 350
pF1KSD NPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNST
310 320 330 340 350 360
360 370 380 390 400 410
pF1KSD HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSP
370 380 390 400 410 420
420 430 440 450 460 470
pF1KSD EHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLT
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD IQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTA
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD TTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECV
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD PGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHV
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD GAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPS
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD SCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCA
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD QGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD
790 800 810 820 830 840
840 850 860 870 880 890
pF1KSD FPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYV
850 860 870 880 890 900
900 910 920 930 940 950
pF1KSD CVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWG
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KSD DHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCV
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KSD NTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPA
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KSD QRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERA
:::::::::: :::
XP_011 QRQCLSPEEM-----------------------------------------------ERA
1090
1140 1150 1160 1170 1180 1190
pF1KSD PERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQS
1100 1110 1120 1130 1140 1150
1200 1210 1220 1230 1240 1250
pF1KSD ESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRAR
1160 1170 1180 1190 1200 1210
1260 1270 1280 1290 1300
pF1KSD CVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
1220 1230 1240 1250 1260
>>XP_016873226 (OMIM: 601216,602090,613097) PREDICTED: l (828 aa)
initn: 5756 init1: 4295 opt: 4377 Z-score: 2452.4 bits: 465.4 E(85289): 7.4e-130
Smith-Waterman score: 5788; 98.6% identity (98.7% similar) in 794 aa overlap (1-784:1-794)
10 20 30 40 50
pF1KSD MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLL-GLGGRVEGGPAGERGAGGGGALARE
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
XP_016 MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KSD RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KSD GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KSD SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAE---------VQAPPPVVNVR
:::::::::::::::::::::::::::::::::::::::: :::::::::::
XP_016 SKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEALRPPRPPPVQAPPPVVNVR
190 200 210 220 230 240
240 250 260 270 280 290
pF1KSD VHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGS
250 260 270 280 290 300
300 310 320 330 340 350
pF1KSD NPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNST
310 320 330 340 350 360
360 370 380 390 400 410
pF1KSD HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSP
370 380 390 400 410 420
420 430 440 450 460 470
pF1KSD EHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLT
430 440 450 460 470 480
480 490 500 510 520 530
pF1KSD IQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTA
490 500 510 520 530 540
540 550 560 570 580 590
pF1KSD TTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECV
550 560 570 580 590 600
600 610 620 630 640 650
pF1KSD PGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHV
610 620 630 640 650 660
660 670 680 690 700 710
pF1KSD GAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPS
670 680 690 700 710 720
720 730 740 750 760 770
pF1KSD SCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCA
730 740 750 760 770 780
780 790 800 810 820 830
pF1KSD QGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD
:::::::::::::.
XP_016 QGYAPAPDGRSCLERSLLLIVEGGLLQRLRAETVVDRMSGGLRMAMRR
790 800 810 820
>>NP_001159738 (OMIM: 150390) latent-transforming growth (1300 aa)
initn: 2706 init1: 552 opt: 2081 Z-score: 1171.8 bits: 229.1 E(85289): 1.6e-58
Smith-Waterman score: 3428; 38.9% identity (59.2% similar) in 1388 aa overlap (60-1298:25-1286)
30 40 50 60 70 80
pF1KSD LLLLLGLGGRVEGGPAGERGAGGGGALARERFKVVFAPVICKRTCLKGQCRDSCQQGSNM
:.::::.: ::: :: ::.:..::..:..
NP_001 MDTKLMCLLFFFSLPPLLVSNHTGRIKVVFTPSICKVTCTKGSCQNSCEKGNTT
10 20 30 40 50
90 100 110 120 130 140
pF1KSD TLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGG
:::.::::..::::...::::.: ::::::::::::..: :::.:::..::.:. ::
NP_001 TLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGA---
60 70 80 90 100 110
150 160 170 180 190 200
pF1KSD TGGSGPGLSRTGALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLV
..: : .:. . :: . : . :.. .
NP_001 -----------------SVPKLY--------QHS--------QQPGKALGTHVIHSTHTL
120 130
210 220 230 240 250
pF1KSD PLG-PGQISAEVQAPPPVVNVRVHHPPEASVQVH---RIESSNAES---AAPSQHL----
:: .: ...:. :: .::..:.::::::::.: ::.. .... : :.:
NP_001 PLTVTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQ
140 150 160 170 180 190
260 270 280 290 300
pF1KSD -LP-------HPKPSHPR------PPTQKP-LGRCFQDTLPKQPCGSNPLPGLTKQEDCC
:: : :: . : . : ::::::.:. .: ::. ::::.::::::
NP_001 GLPVQKTQTIHSTYSHQQVIPHVYPVAAKTQLGRCFQETIGSQ-CGKA-LPGLSKQEDCC
200 210 220 230 240 250
310 320 330 340 350 360
pF1KSD GSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGV
:..::.:: .::.:::. ::. . .: ::::.:.: ::::::: . ::
NP_001 GTVGTSWGFNKCQKCPK-------KPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQGV
260 270 280 290 300
370 380 390 400 410 420
pF1KSD CRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKP---EEKSLCFRLVSPEHQCQHPLTT
: .:.:::. :::::.: : . :. ..:. : : :::. :.:::: .::.:::..
NP_001 CPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSV
310 320 330 340 350 360
430 440 450 460 470 480
pF1KSD RLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLF
.::.:::::::::::: .:..:: ::: . . ..::.. :
NP_001 HLTKQLCCCSVGKAWGPHCEKCPLPGTAKEEPV-------------EALTFSRE------
370 380 390 400 410
490 500 510 520 530
pF1KSD LHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARP-YP
: : .:. : . : : :. . . .: : : .: .: .:
NP_001 -HGPGVAEPEVATAPPEKEIPSLDQEKTK-LEPGQP--------QLSPGISTIHLHPQFP
420 430 440 450 460
540 550 560 570 580 590
pF1KSD ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH
.: . :::. :. : .. :::::::: .:: .: .::: :.:. : :.:
NP_001 VVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCI
470 480 490 500 510 520
600 610 620 630 640 650
pF1KSD CNPGYRSHPQHRYCVDVNECEAEP--CGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSC
: ::: :.: :::..:: :. :: : :: ::. : : :. .. : .:
NP_001 CYEGYRFSEQQRKCVDIDECTQVQHLCSQGR--CENTEGSFLCICPAGF--MASEEGTNC
530 540 550 560 570
660 670 680 690 700 710
pF1KSD VDLNECAKPHLCGDGGFCINFPGHYKCN-CYPGYRLKASRPPVCEDIDECRDPSSCPDGK
.:..:: .: .::.: :.: : ..:. : :::. .. ::::::: .::.::: .
NP_001 IDVDECLRPDVCGEG-HCVNTVGAFRCEYCDSGYRM--TQRGRCEDIDECLNPSTCPDEQ
580 590 600 610 620 630
720 730 740 750 760 770
pF1KSD CENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPA
: :.:::..:. : :.:. .: : ::.:: : . :. : : :: ::. :.: .::. .
NP_001 CVNSPGSYQCVPCTEGFRGWNG-QCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRT
640 650 660 670 680 690
780 790 800 810 820 830
pF1KSD PDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD------
:: . : :.:::. :..: :: :.:: :::.: : .::.:: ...:::::::.
NP_001 PDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCA
700 710 720 730 740 750
840 850
pF1KSD ----------FPAAC--------IG------------------GDCINTNGSYRCLCPQG
: .: .: :::::: ::: : ::.:
NP_001 HGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDG
760 770 780 790 800 810
860 870 880 890 900
pF1KSD HRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEV-----
.: .. ::::.:: . :.:: :.: : : .::. :::..::. . : . ::.:
NP_001 FQLDDNKTCQDINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDVNECEL
820 830 840 850 860 870
910 920
pF1KSD -----------------------------------------------EQPHH-KKECYLN
.::.. ::::: :
NP_001 LSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYN
880 890 900 910 920 930
930 940 950 960 970 980
pF1KSD FDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQ-DN
..:. .::.::: :::.:::::. ::::::.:::.:::: ..::: .:: :::.. .
NP_001 LNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGE
940 950 960 970 980 990
990 1000 1010 1020 1030 1040
pF1KSD NIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECL
. . : ..: :::.:::.::::.: :.::.:::::::::: ::: :.: :.:::
NP_001 SSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQ
1000 1010 1020 1030 1040 1050
1050 1060 1070 1080 1090 1100
pF1KSD DESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLP
: :.: .: : ::.:.: : :: : . ....:. : :
NP_001 DPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAE---------------------
1060 1070 1080 1090
1110 1120 1130 1140 1150 1160
pF1KSD GSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDD
. :. :. . .:.:: . ... .:. ::.: :. .
NP_001 -----------------SNEQIEETDV-----YQDLCWEHLSDEYVCSRPLVGKQTTYTE
1100 1110 1120
1170 1180 1190 1200
pF1KSD CCCRQGRGWGAQCRPCPPRGAGSH---C--PTSQSES----NSFWDTSPLLLGK--PPRD
::: :..:: :: :: . . .. : :.. .. ... : : . :
NP_001 CCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFI
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240 1250 1260
pF1KSD ED----SSEE-DSDECR----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECREL
.: : :: ...:: : .:::: : .:.: :..::... :::..:: ::
NP_001 QDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDEL
1190 1200 1210 1220 1230 1240
1270 1280 1290 1300
pF1KSD NQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
:.: :::. .:.::.::..:.: :.. : . :.:
NP_001 NNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALNLEKDSDLE
1250 1260 1270 1280 1290 1300
>>XP_005264375 (OMIM: 150390) PREDICTED: latent-transfor (1626 aa)
initn: 2701 init1: 552 opt: 2080 Z-score: 1169.9 bits: 229.1 E(85289): 2e-58
Smith-Waterman score: 3423; 38.8% identity (59.2% similar) in 1388 aa overlap (60-1298:351-1612)
30 40 50 60 70 80
pF1KSD LLLLLGLGGRVEGGPAGERGAGGGGALARERFKVVFAPVICKRTCLKGQCRDSCQQGSNM
:.::::.: ::: :: ::.:..::..:..
XP_005 SGEQSTEGSFPLRYVQDQVAAPFQLSNHTGRIKVVFTPSICKVTCTKGSCQNSCEKGNTT
330 340 350 360 370 380
90 100 110 120 130 140
pF1KSD TLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGG
:::.::::..::::...::::.: ::::::::::::..: :::.:::..::.:. ::
XP_005 TLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGA---
390 400 410 420 430
150 160 170 180 190 200
pF1KSD TGGSGPGLSRTGALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLV
..: : .:. . :: . : . :.. .
XP_005 -----------------SVPKLY--------QHS--------QQPGKALGTHVIHSTHTL
440 450 460
210 220 230 240 250
pF1KSD PLG-PGQISAEVQAPPPVVNVRVHHPPEASVQVH---RIESSNAES---AAPSQHL----
:: .: ...:. :: .::..:.::::::::.: ::.. .... : :.:
XP_005 PLTVTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQ
470 480 490 500 510 520
260 270 280 290 300
pF1KSD -LP-------HPKPSHPR------PPTQKP-LGRCFQDTLPKQPCGSNPLPGLTKQEDCC
:: : :: . : . : ::::::.:. .: ::. ::::.::::::
XP_005 GLPVQKTQTIHSTYSHQQVIPHVYPVAAKTQLGRCFQETIGSQ-CGKA-LPGLSKQEDCC
530 540 550 560 570 580
310 320 330 340 350 360
pF1KSD GSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGV
:..::.:: .::.:::. ::. . .: ::::.:.: ::::::: . ::
XP_005 GTVGTSWGFNKCQKCPK-------KPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQGV
590 600 610 620 630
370 380 390 400 410 420
pF1KSD CRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKP---EEKSLCFRLVSPEHQCQHPLTT
: .:.:::. :::::.: : . :. ..:. : : :::. :.:::: .::.:::..
XP_005 CPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSV
640 650 660 670 680 690
430 440 450 460 470 480
pF1KSD RLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLF
.::.:::::::::::: .:..:: ::: . . ..::.. :
XP_005 HLTKQLCCCSVGKAWGPHCEKCPLPGTAKEEPV-------------EALTFSRE------
700 710 720 730
490 500 510 520 530
pF1KSD LHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARP-YP
: : .:. : . : : :. . . .: : : .: .: .:
XP_005 -HGPGVAEPEVATAPPEKEIPSLDQEKTK-LEPGQP--------QLSPGISTIHLHPQFP
740 750 760 770 780
540 550 560 570 580 590
pF1KSD ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCH
.: . :::. :. : .. :::::::: .:: .: .::: :.:. : :.:
XP_005 VVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCI
790 800 810 820 830 840
600 610 620 630 640 650
pF1KSD CNPGYRSHPQHRYCVDVNECEAEP--CGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSC
: ::: :.: :::..:: :. :: : :: ::. : : :. .. : .:
XP_005 CYEGYRFSEQQRKCVDIDECTQVQHLCSQGR--CENTEGSFLCICPAGF--MASEEGTNC
850 860 870 880 890 900
660 670 680 690 700 710
pF1KSD VDLNECAKPHLCGDGGFCINFPGHYKCN-CYPGYRLKASRPPVCEDIDECRDPSSCPDGK
.:..:: .: .::.: :.: : ..:. : :::. .. ::::::: .::.::: .
XP_005 IDVDECLRPDVCGEG-HCVNTVGAFRCEYCDSGYRM--TQRGRCEDIDECLNPSTCPDEQ
910 920 930 940 950
720 730 740 750 760 770
pF1KSD CENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPA
: :.:::..:. : :.:. .: : ::.:: : . :. : : :: ::. :.: .::. .
XP_005 CVNSPGSYQCVPCTEGFRGWNG-QCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRT
960 970 980 990 1000 1010
780 790 800 810 820 830
pF1KSD PDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECD------
:: . : :.:::. :..: :: :.:: :::.: : .::.:: ...:::::::.
XP_005 PDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCA
1020 1030 1040 1050 1060 1070
840 850
pF1KSD ----------FPAAC--------IG------------------GDCINTNGSYRCLCPQG
: .: .: :::::: ::: : ::.:
XP_005 HGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDG
1080 1090 1100 1110 1120 1130
860 870 880 890 900
pF1KSD HRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEV-----
.: .. ::::.:: . :.:: :.: : : .::. :::..::. . : . ::.:
XP_005 FQLDDNKTCQDINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDVNECEL
1140 1150 1160 1170 1180 1190
910 920
pF1KSD -----------------------------------------------EQPHH-KKECYLN
.::.. ::::: :
XP_005 LSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYN
1200 1210 1220 1230 1240 1250
930 940 950 960 970 980
pF1KSD FDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQ-DN
..:. .::.::: :::.:::::. :.::::.:::.:::: ..::: .:: :::.. .
XP_005 LNDASLCDNVLAPNVTKQECCCTSGVGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGE
1260 1270 1280 1290 1300 1310
990 1000 1010 1020 1030 1040
pF1KSD NIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECL
. . : ..: :::.:::.::::.: :.::.:::::::::: ::: :.: :.:::
XP_005 SSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQ
1320 1330 1340 1350 1360 1370
1050 1060 1070 1080 1090 1100
pF1KSD DESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLP
: :.: .: : ::.:.: : :: : . ....:. : :
XP_005 DPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAE---------------------
1380 1390 1400 1410
1110 1120 1130 1140 1150 1160
pF1KSD GSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDD
. :. :. . .:.:: . ... .:. ::.: :. .
XP_005 -----------------SNEQIEETDV-----YQDLCWEHLSDEYVCSRPLVGKQTTYTE
1420 1430 1440 1450
1170 1180 1190 1200
pF1KSD CCCRQGRGWGAQCRPCPPRGAGSH---C--PTSQSES----NSFWDTSPLLLGK--PPRD
::: :..:: :: :: . . .. : :.. .. ... : : . :
XP_005 CCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFI
1460 1470 1480 1490 1500 1510
1210 1220 1230 1240 1250 1260
pF1KSD ED----SSEE-DSDECR----CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECREL
.: : :: ...:: : .:::: : .:.: :..::... :::..:: ::
XP_005 QDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDEL
1520 1530 1540 1550 1560 1570
1270 1280 1290 1300
pF1KSD NQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
:.: :::. .:.::.::..:.: :.. : . :.:
XP_005 NNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALNLEKDSDLE
1580 1590 1600 1610 1620
>>XP_011525681 (OMIM: 604710,613177) PREDICTED: latent-t (1595 aa)
initn: 1605 init1: 371 opt: 2048 Z-score: 1152.2 bits: 225.8 E(85289): 1.9e-57
Smith-Waterman score: 2443; 34.2% identity (53.7% similar) in 1375 aa overlap (18-1257:2-1271)
10 20 30 40 50 60
pF1KSD MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLGLGGRVEGGPAGERGAGGGGALARER
::.. :: . ::.:: .. :: . : : : ::
XP_011 MAGGVRLLWVSLLVLL-------AQLGP--QPGLGRLG----ER
10 20 30
70 80 90 100 110
pF1KSD FKVVFAPVICKRTCLKG----QCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPC
..: :.::.: :..: .: .: : : . .. . . : :::. .::: :
XP_011 LRVRFTPVVCGLRCVHGPTGSRCTPTCAP-RNATSVDSGAPGGAAPGGPGFRAFLCPLIC
40 50 60 70 80 90
120 130 140 150 160 170
pF1KSD MNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGD
::: : . ..:::::::.:.:::. ..:: . . :::.: :. ..: :: . :
XP_011 HNGGVCVKPDRCLCPPDFAGKFCQLHSSGARP-PAPAVPGLTR----SVYTMP-LANHRD
100 110 120 130 140
180 190 200 210 220 230
pF1KSD SVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPE
. .:.. : .: . : :. . : . : :: . :...:
XP_011 D---EHGV-ASMVSVHVEHPQEASVVVHQVERVS-GPWE-EADAEA--------------
150 160 170 180
240 250 260 270 280 290
pF1KSD ASVQVHRIESSN-AESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPG
: : :.. ::.::: .: . : . . .: ::.. : :.: ::::
XP_011 ----VARAEAAARAEAAAP-YTVLAQSAPREDGYSDASGFGYCFRE-LRGGECAS-PLPG
190 200 210 220 230
300 310 320 330 340 350
pF1KSD LTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDI
: :: :: . : ::: :. : . .. . .: . :: :..:.:.. :.:.
XP_011 LRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAP-----DGPCPTGFERVNGS-CEDV
240 250 260 270 280 290
360 370 380 390 400 410
pF1KSD NECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADK--PEEKSLCFRLVSPEHQ
.::: : :.::.: :. :.: :::: : : ::..::... : :. :::.. .
XP_011 DECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLR-DGG
300 310 320 330 340 350
420 430 440 450 460 470
pF1KSD CQHPLTTRLTRQLCCCS-VGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQ
:. :. .:.:.:::: :::::: :: :: :. .:.:::::: :::
XP_011 CSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHY----------
360 370 380 390 400
480 490 500 510
pF1KSD GESDFSLFLHPDG--PPK-----PQQLPES--PSQAPP------------PEDTEEERGV
. ::. .: : ::. :. :: . :: . :. :.:
XP_011 SASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGELALAEVGAIFKGLPQPHSERRQE
410 420 430 440 450 460
520 530 540 550
pF1KSD TTDSPVSEERSVQQSHPTATTTPARPYPELISRPSP----PTM-RWFLPDLP--------
.:. . :.. :: : :: :. ::.: :.. : :..:
XP_011 RIWAPLVDTPSLSGFLPTHRLEP-RPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGM
470 480 490 500 510
560 570 580 590
pF1KSD ---------PSR-------------SAVEIAP--TQVTETDECRLNQNICGHGECVPGPP
:.: :. ...: :. ..:::: :. :.: .:
XP_011 CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPG
520 530 540 550 560 570
600 610 620 630 640 650
pF1KSD DYSCHCNPGYRSHPQHRYCVDVNECE--AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGA
.. : :.::.:. :. :.::.::. :: :: : :: ::. : : :: ...
XP_011 SFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGR--CENTPGSFLCVCPAGY--QAAP
580 590 600 610 620 630
660 670 680 690 700
pF1KSD GGRSCVDLNECAK-PHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCE-DIDEC-RDP
: :: :..::.. : ::: :. : :.:: ..: : :.: .: :: :.::: ..:
XP_011 HGASCQDVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSA-----CEEDVDECAQEP
640 650 660 670 680
710 720 730 740 750 760
pF1KSD SSCPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSP-CSPGWCENLPGSFRC
: :.:.: :::.: :: :.::.: :: :.::.:::.. : :. : ::: :::.:
XP_011 PPCGPGRCDNTAGSFHC-ACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQC
690 700 710 720 730 740
770 780 790 800 810 820
pF1KSD TCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQ-CLSGYHLSRDRSHCEDI
.: .:. : : : :::::: .: . : :.::::::. : ::.:: : : : :.
XP_011 VCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDV
750 760 770 780 790 800
830 840 850 860 870 880
pF1KSD DECDFPAACIG--GDCINTNGSYRCLCPQGHRLVGGRK--CQDIDECSQDPSLCLPHGAC
:::. : : : : ::.::.:: : :.: .:: : :..:: . ..:.::: :
XP_011 DECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNEC-LEGDFCFPHGEC
810 820 830 840 850 860
890 900 910 920 930 940
pF1KSD KNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQ-EC
: .::..:.: :. : .: .:. :: . .: .:.: . ::. . ::
XP_011 LNTDGSFACTCAPGYRPGPRGASCLDVD------EC--SEED--LCQSGICTNTDGSFEC
870 880 890 900 910
950 960 970 980 990
pF1KSD CCSLGAGWGDH---C-EIYPCPVYSSAEFHSL-CPDGKGY---TQDNNIVNYGIPAHR--
: : : : .. : . : : : .. : ..: . .. :
XP_011 ICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCD
920 930 940 950 960 970
1000 1010 1020 1030 1040
pF1KSD DIDECMLFGSEICKEGKCVNTQPGYECY--CKQGFYYDGNLLECVDVDECLDESNC-RNG
:.:::. .: ::: .: :: .:.: : : : : ::::: ..: : ..
XP_011 DVDECQEYGPEICGAQRCENTPGSYRCTPACDPG-YQPTPGGGCQDVDECRNRSFCGAHA
980 990 1000 1010 1020 1030
1050 1060 1070 1080 1090 1100
pF1KSD VCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQD-PAACRPGRCVNLPGSYRC--
::.: :...: : : . :.:. ::.::. ..: . : :. ::. :
XP_011 VCQNLPGSFQCLCDQGYEGARDGRHCV-----DVNECETLQGVCGAALCENVEGSFLCVC
1040 1050 1060 1070 1080
1110 1120 1130
pF1KSD ------------ECRPPWVPGPS--GRDCQLPESPAERA-------PER-----------
.: :: . . . : . : : ::. : :.:
XP_011 PNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGS
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KSD -RDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSES
: :. . . : . :: .:...::: :.:::. :: ..:: .:.
XP_011 GRRECYFDTAAPDACDNILAR-NVTWQECCCTVGEGWGSGCRI-------QQCPG--TET
1150 1160 1170 1180 1190
1200 1210 1220 1230 1240
pF1KSD NSFWDTSPLLLGK-PPRDEDSSEEDSDECR------CVSGRCVPRPGGAVCECPGGFQLD
. . : : : . : ..: :::. : :: :: : : : .:.
XP_011 AEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYH
1200 1210 1220 1230 1240 1250
1250 1260 1270 1280 1290 1300
pF1KSD ASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
..: .:.: :::
XP_011 TQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNL
1260 1270 1280 1290 1300 1310
>--
initn: 550 init1: 281 opt: 371 Z-score: 218.9 bits: 53.1 E(85289): 1.9e-05
Smith-Waterman score: 464; 29.9% identity (50.3% similar) in 314 aa overlap (364-646:1278-1579)
340 350 360 370 380 390
pF1KSD GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC
:. : :.:. :::.:.: : : :. .:
XP_011 YSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRC
1250 1260 1270 1280 1290 1300
400 410 420 430 440
pF1KSD IADKPE----EKSLCFRLVSPEHQCQHP-LTTRLTRQLCCCSVGKAWGARCQRCPTDGTA
.... . . ..:.. :. . :.:: : . : ::: :.::: : ::.. .
XP_011 VSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCPAQDSD
1310 1320 1330 1340 1350 1360
450 460 470 480 490 500
pF1KSD AFKEICPAGKGYHILTSHQTLTIQGESDFSLFLH--PD-GPPKPQQLPESPSQAPPPEDT
:. .: ..: . . . :.: . :: ::: : :: .: :::
XP_011 DFEALC------NVLRP-PAYSPPRPGGFGLPYEYGPDLGPPY-QGLPYGPELYPPPALP
1370 1380 1390 1400 1410
510 520 530 540 550
pF1KSD EEERGVTTDSPVSEERSVQQSHPTATTTPAR----PYPELISRPSPPT--MRWFL-----
. .: .. : . . : . :: : . :.:: ::
XP_011 YDPYP-PPPGPFAR-REAPYGAPRFDMPDFEDDGGPYGESEA-PAPPGPGTRWPYRSRDT
1420 1430 1440 1450 1460 1470
560 570 580 590 600
pF1KSD ------PDLPP---SRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYR
:. :: : .. : . :..:: . . : .:.:: : ..:.: :::
XP_011 RRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGI-LDGCTNGRCVRVPEGFTCRCFDGYR
1480 1490 1500 1510 1520 1530
610 620 630 640 650 660
pF1KSD SHPQHRYCVDVNEC-EAEPCGPG--RGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNE
. :::.::: ::: .: . :.:: ::. : : :.
XP_011 LDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA
1540 1550 1560 1570 1580 1590
670 680 690 700 710 720
pF1KSD CAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPG
>>XP_011525678 (OMIM: 604710,613177) PREDICTED: latent-t (1662 aa)
initn: 1581 init1: 371 opt: 2048 Z-score: 1152.0 bits: 225.8 E(85289): 2e-57
Smith-Waterman score: 2342; 34.5% identity (53.8% similar) in 1279 aa overlap (110-1257:151-1338)
80 90 100 110 120 130
pF1KSD RDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFC
:.::: : ::: : . ..:::::::.:.::
XP_011 LLKRRRPRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFC
130 140 150 160 170 180
140 150 160 170 180 190
pF1KSD QVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEG
:. ..:: . . :::.: :. ..: :: . :. .:.. : .: . : :.
XP_011 QLHSSGARP-PAPAVPGLTR----SVYTMP-LANHRDD---EHGV-ASMVSVHVEHPQEA
190 200 210 220 230
200 210 220 230 240 250
pF1KSD PPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASVQVHRIESSN-AESAAPSQHL
. : . : :: . :...: : : :.. ::.::: .
XP_011 SVVVHQVERVS-GPWE-EADAEA------------------VARAEAAARAEAAAPYT-V
240 250 260
260 270 280 290 300 310
pF1KSD LPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKC
: . : . . .: ::.. : :.: ::::: :: :: . : ::: :. :
XP_011 LAQSAPREDGYSDASGFGYCFRE-LRGGECAS-PLPGLRTQEVCCRGAGLAWGVHDCQLC
270 280 290 300 310 320
320 330 340 350 360 370
pF1KSD PQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRC
. .. . .: . :: :..:.:.. :.:..::: : :.::.: :. :.: :
XP_011 SERLGNSERVSAP-----DGPCPTGFERVNGS-CEDVDECATGGRCQHGECANTRGGYTC
330 340 350 360 370 380
380 390 400 410 420 430
pF1KSD VCPPGHSLGPSRTQCIADK--PEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCS-VGKAW
::: : : ::..::... : :. :::.. . :. :. .:.:.:::: :::::
XP_011 VCPDGFLLDSSRSSCISQHVISEAKGPCFRVLR-DGGCSLPILRNITKQICCCSRVGKAW
390 400 410 420 430 440
440 450 460 470 480
pF1KSD GARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDG--PPK-----
: :: :: :. .:.:::::: ::: . ::. .: : ::.
XP_011 GRGCQLCPPFGSEGFREICPAGPGYHY----------SASDLRYNTRPLGQEPPRVSLSQ
450 460 470 480 490
490 500 510 520 530
pF1KSD PQQLPES--PSQAPP------------PEDTEEERGVTTDSPVSEERSVQQSHPTATTTP
:. :: . :: . :. :.: .:. . :.. :: :
XP_011 PRTLPATSRPSAGELALAEVGAIFKGLPQPHSERRQERIWAPLVDTPSLSGFLPTHRLEP
500 510 520 530 540 550
540 550 560
pF1KSD ARPYPELISRPSP----PTM-RWFLPDLP-----------------PSR-----------
:: :. ::.: :.. : :..: :.:
XP_011 -RPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCA
560 570 580 590 600
570 580 590 600 610
pF1KSD --SAVEIAP--TQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVN
:. ...: :. ..:::: :. :.: .: .. : :.::.:. :. :.::.
XP_011 CDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVD
610 620 630 640 650 660
620 630 640 650 660 670
pF1KSD ECE--AEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAK-PHLCGDGGF
::. :: :: : :: ::. : : ::. .. : :: :..::.. : ::: :.
XP_011 ECHRVPPPCDLGR--CENTPGSFLCVCPAGYQ--AAPHGASCQDVDECTQSPGLCGRGA-
670 680 690 700 710 720
680 690 700 710 720 730
pF1KSD CINFPGHYKCNCYPGYRLKASRPPVCE-DIDEC-RDPSSCPDGKCENKPGSFKCIACQPG
: :.:: ..: : :.: .: :: :.::: ..: : :.:.: :::.: :: :
XP_011 CKNLPGSFRCVCPAGFRGSA-----CEEDVDECAQEPPPCGPGRCDNTAGSFHC-ACPAG
730 740 750 760 770
740 750 760 770 780 790
pF1KSD YRSQGGGA-CRDVNECAEGSP-CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA
.::.: :: :.::.:::.. : :. : ::: :::.:.: .:. : : : ::::::
XP_011 FRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECEN
780 790 800 810 820 830
800 810 820 830 840
pF1KSD GDVCDNGICSNTPGSFQCQ-CLSGYHLSRDRSHCEDIDECDFPAACIG--GDCINTNGSY
.: . : :.::::::. : ::.:: : : : :.:::. : : : : ::.::.
XP_011 HLACPGQECVNSPGSFQCRTCPSGHHLHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSF
840 850 860 870 880 890
850 860 870 880 890 900
pF1KSD RCLCPQGHRLVGGRK--CQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHG
:: : :.: .:: : :..:: . ..:.::: : : .::..:.: :. : .
XP_011 RCSCAPGYRAPSGRPGPCADVNEC-LEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGAS
900 910 920 930 940 950
910 920 930 940 950 960
pF1KSD CEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQ-ECCCSLGAGWGDH---C-EIYPCPV
: .:. :: . .: .:.: . ::. . :: : : : : .. :
XP_011 CLDVD------EC--SEED--LCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRE
960 970 980 990 1000
970 980 990 1000 1010
pF1KSD YSSAEFHSL-CPDGKGY---TQDNNIVNYGIPAHR--DIDECMLFGSEICKEGKCVNTQP
. : : : .. : ..: . .. : :.:::. .: ::: .: ::
XP_011 RGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPG
1010 1020 1030 1040 1050 1060
1020 1030 1040 1050 1060 1070
pF1KSD GYECY--CKQGFYYDGNLLECVDVDECLDESNC-RNGVCENTRGGYRCACTPPAEYSPAQ
.:.: : : : : ::::: ..: : ..::.: :...: : : .
XP_011 SYRCTPACDPG-YQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDG
1070 1080 1090 1100 1110 1120
1080 1090 1100 1110
pF1KSD RQCLSPEEMDVDECQD-PAACRPGRCVNLPGSYRC--------------ECRPPWVPGPS
:.:. ::.::. ..: . : :. ::. : .: :: . . .
XP_011 RHCV-----DVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGT
1130 1140 1150 1160 1170
1120 1130 1140 1150
pF1KSD --GRDCQLPESPAERA-------PER------------RDVCWSQRGEDGMCAGPLAGPA
: . : : ::. : :.: : :. . . : . ::
XP_011 FPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILAR-N
1180 1190 1200 1210 1220 1230
1160 1170 1180 1190 1200 1210
pF1KSD LTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGK-PPRDEDSSE
.:...::: :.:::. :: ..:: .:. . . : : : . : .
XP_011 VTWQECCCTVGEGWGSGCRI-------QQCPG--TETAEYQSLCPHGRGYLAPSGDLSLR
1240 1250 1260 1270 1280
1220 1230 1240 1250 1260
pF1KSD EDSDECR------CVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCK
.: :::. : :: :: : : : .:. ..: .:.: :::
XP_011 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGR
1290 1300 1310 1320 1330 1340
1270 1280 1290 1300
pF1KSD SERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR
XP_011 CVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQAT
1350 1360 1370 1380 1390 1400
>--
initn: 550 init1: 281 opt: 371 Z-score: 218.6 bits: 53.1 E(85289): 1.9e-05
Smith-Waterman score: 464; 29.9% identity (50.3% similar) in 314 aa overlap (364-646:1345-1646)
340 350 360 370 380 390
pF1KSD GEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQC
:. : :.:. :::.:.: : : :. .:
XP_011 YSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRC
1320 1330 1340 1350 1360 1370
400 410 420 430 440
pF1KSD IADKPE----EKSLCFRLVSPEHQCQHP-LTTRLTRQLCCCSVGKAWGARCQRCPTDGTA
.... . . ..:.. :. . :.:: : . : ::: :.::: : ::.. .
XP_011 VSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCPAQDSD
1380 1390 1400 1410 1420 1430
450 460 470 480 490 500
pF1KSD AFKEICPAGKGYHILTSHQTLTIQGESDFSLFLH--PD-GPPKPQQLPESPSQAPPPEDT
:. .: ..: . . . :.: . :: ::: : :: .: :::
XP_011 DFEALC------NVLRP-PAYSPPRPGGFGLPYEYGPDLGPPY-QGLPYGPELYPPPALP
1440 1450 1460 1470 1480
510 520 530 540 550
pF1KSD EEERGVTTDSPVSEERSVQQSHPTATTTPAR----PYPELISRPSPPT--MRWFL-----
. .: .. : . . : . :: : . :.:: ::
XP_011 YDPYP-PPPGPFAR-REAPYGAPRFDMPDFEDDGGPYGESEA-PAPPGPGTRWPYRSRDT
1490 1500 1510 1520 1530 1540
560 570 580 590 600
pF1KSD ------PDLPP---SRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYR
:. :: : .. : . :..:: . . : .:.:: : ..:.: :::
XP_011 RRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGI-LDGCTNGRCVRVPEGFTCRCFDGYR
1550 1560 1570 1580 1590 1600
610 620 630 640 650 660
pF1KSD SHPQHRYCVDVNEC-EAEPCGPG--RGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNE
. :::.::: ::: .: . :.:: ::. : : :.
XP_011 LDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA
1610 1620 1630 1640 1650 1660
670 680 690 700 710 720
pF1KSD CAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPG
1302 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 08:51:01 2016 done: Thu Nov 3 08:51:04 2016
Total Scan time: 17.250 Total Display time: 0.570
Function used was FASTA [36.3.4 Apr, 2011]